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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ABR-SAYSD1 (FusionGDB2 ID:680)

Fusion Gene Summary for ABR-SAYSD1

Fusion gene summary

Fusion gene information	Fusion gene name: ABR-SAYSD1
	Fusion gene ID: 680
		Hgene	Tgene
	Gene symbol	ABR	SAYSD1
	Gene ID	29	55776
	Gene name	ABR activator of RhoGEF and GTPase	SAYSVFN motif domain containing 1
	Synonyms	MDB	C6orf64
	Cytomap	17p13.3	6p21.2
	Type of gene	protein-coding	protein-coding
	Description	active breakpoint cluster region-related proteinABR, RhoGEF and GTPase activating proteinactive BCR-related	SAYSvFN domain-containing protein 1
	Modification date	20200313	20200313
	UniProtAcc	.	Q9NPB0
	Ensembl transtripts involved in fusion gene	ENST00000302538, ENST00000544583, ENST00000572441, ENST00000574437, ENST00000291107, ENST00000543210, ENST00000536794, ENST00000573895,	ENST00000373249, ENST00000229903, ENST00000481599,
Fusion gene scores	* DoF score	23 X 15 X 14=4830	2 X 1 X 2=4
	# samples	36	2
	** MAII score	log2(36/4830*10)=-3.74595437739346 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/4*10)=2.32192809488736
Context	PubMed: ABR [Title/Abstract] AND SAYSD1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ABR(953289)-SAYSD1(39073552), # samples:1
Anticipated loss of major functional domain due to fusion event.	ABR-SAYSD1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ABR	GO:0090630	activation of GTPase activity	7479768

Fusion gene breakpoints across ABR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SAYSD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	5263N	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-

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Fusion Gene ORF analysis for ABR-SAYSD1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000302538	ENST00000373249	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-
Frame-shift	ENST00000302538	ENST00000229903	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-
5CDS-intron	ENST00000302538	ENST00000481599	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-
Frame-shift	ENST00000544583	ENST00000373249	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-
In-frame	ENST00000544583	ENST00000229903	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-
5CDS-intron	ENST00000544583	ENST00000481599	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-
intron-3CDS	ENST00000572441	ENST00000373249	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-
intron-3CDS	ENST00000572441	ENST00000229903	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-
intron-intron	ENST00000572441	ENST00000481599	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-
Frame-shift	ENST00000574437	ENST00000373249	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-
Frame-shift	ENST00000574437	ENST00000229903	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-
5CDS-intron	ENST00000574437	ENST00000481599	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-
Frame-shift	ENST00000291107	ENST00000373249	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-
Frame-shift	ENST00000291107	ENST00000229903	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-
5CDS-intron	ENST00000291107	ENST00000481599	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-
intron-3CDS	ENST00000543210	ENST00000373249	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-
intron-3CDS	ENST00000543210	ENST00000229903	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-
intron-intron	ENST00000543210	ENST00000481599	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-
Frame-shift	ENST00000536794	ENST00000373249	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-
Frame-shift	ENST00000536794	ENST00000229903	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-
5CDS-intron	ENST00000536794	ENST00000481599	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-
intron-3CDS	ENST00000573895	ENST00000373249	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-
intron-3CDS	ENST00000573895	ENST00000229903	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-
intron-intron	ENST00000573895	ENST00000481599	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000544583

ABR

chr17

953289

ENST00000229903

SAYSD1

chr6

39073552

3966

2253

600

2597

665

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000544583	ENST00000229903	ABR	chr17	953289	-	SAYSD1	chr6	39073552	-	0.00250504	0.99749494

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Fusion Genomic Features for ABR-SAYSD1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ABR-SAYSD1

Go to
FGviewer for the breakpoints of chr17:953289-chr6:39073552
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	SAYSD1 Q9NPB0
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ABR

chr17:953289

chr6:39073552

ENST00000291107

417_420

560.0

823.0

Compositional bias

Note=Poly-Leu

Hgene

ABR

chr17:953289

chr6:39073552

ENST00000302538

417_420

597.0

860.0

Compositional bias

Note=Poly-Leu

Hgene

ABR

chr17:953289

chr6:39073552

ENST00000544583

417_420

551.0

814.0

Compositional bias

Note=Poly-Leu

Hgene

ABR

chr17:953289

chr6:39073552

ENST00000574437

417_420

551.0

814.0

Compositional bias

Note=Poly-Leu

Hgene

ABR

chr17:953289

chr6:39073552

ENST00000291107

301_459

560.0

823.0

Domain

Hgene

ABR

chr17:953289

chr6:39073552

ENST00000291107

91_284

560.0

823.0

Domain

Hgene

ABR

chr17:953289

chr6:39073552

ENST00000302538

301_459

597.0

860.0

Domain

Hgene

ABR

chr17:953289

chr6:39073552

ENST00000302538

91_284

597.0

860.0

Domain

Hgene

ABR

chr17:953289

chr6:39073552

ENST00000544583

301_459

551.0

814.0

Domain

Hgene

ABR

chr17:953289

chr6:39073552

ENST00000544583

91_284

551.0

814.0

Domain

Hgene

ABR

chr17:953289

chr6:39073552

ENST00000574437

301_459

551.0

814.0

Domain

Hgene

ABR

chr17:953289

chr6:39073552

ENST00000574437

91_284

551.0

814.0

Domain

Tgene

SAYSD1

chr17:953289

chr6:39073552

ENST00000373249

6_44

2.0

117.0

Compositional bias

Note=Ala-rich

Tgene

SAYSD1

chr17:953289

chr6:39073552

ENST00000229903

106_126

69.0

184.0

Transmembrane

Helical

Tgene

SAYSD1

chr17:953289

chr6:39073552

ENST00000373249

106_126

2.0

117.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ABR

chr17:953289

chr6:39073552

ENST00000543210

417_420

311.0

Compositional bias

Note=Poly-Leu

Hgene

ABR

chr17:953289

chr6:39073552

ENST00000291107

484_613

560.0

823.0

Domain

Hgene

ABR

chr17:953289

chr6:39073552

ENST00000291107

647_845

560.0

823.0

Domain

Rho-GAP

Hgene

ABR

chr17:953289

chr6:39073552

ENST00000302538

484_613

597.0

860.0

Domain

Hgene

ABR

chr17:953289

chr6:39073552

ENST00000302538

647_845

597.0

860.0

Domain

Rho-GAP

Hgene

ABR

chr17:953289

chr6:39073552

ENST00000543210

301_459

311.0

Domain

Hgene

ABR

chr17:953289

chr6:39073552

ENST00000543210

484_613

311.0

Domain

Hgene

ABR

chr17:953289

chr6:39073552

ENST00000543210

647_845

311.0

Domain

Rho-GAP

Hgene

ABR

chr17:953289

chr6:39073552

ENST00000543210

91_284

311.0

Domain

Hgene

ABR

chr17:953289

chr6:39073552

ENST00000544583

484_613

551.0

814.0

Domain

Hgene

ABR

chr17:953289

chr6:39073552

ENST00000544583

647_845

551.0

814.0

Domain

Rho-GAP

Hgene

ABR

chr17:953289

chr6:39073552

ENST00000574437

484_613

551.0

814.0

Domain

Hgene

ABR

chr17:953289

chr6:39073552

ENST00000574437

647_845

551.0

814.0

Domain

Rho-GAP

Tgene

SAYSD1

chr17:953289

chr6:39073552

ENST00000229903

6_44

69.0

184.0

Compositional bias

Note=Ala-rich

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Fusion Gene Sequence for ABR-SAYSD1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000544583_ENST00000229903_5263N_ABR_chr17_953289_-_SAYSD1_chr6_39073552_length(transcript)=3966nt_BP=2253nt
GGACTGCAGAGGGAACTTGCCTTGAAGAGGCCTGGTCCTTAAAGAGACACAGCACACACGGCCCGACCGGCAGCCCCAGAGCAGAGGCTC
CACTGATGGCAGGCGCCCCTGGCTAGGCTCTGAGGTTCCTTTGCCCTCGCCTTGCTGAATGGTGAGCCGCTGCCTCTCGGAGCCCGTCTC
CTTGACAGCCTGCCCTCGGCTCCTGCAGCCACTCCTGGGCCTGATGGGGACAGGGCCAGCCTGGTGGGTGGTGTCAGAGGTCCTGGCAGA
GCAGCGTAGGCCTGGGATGCGTCTGCAGAATTCTGGCTGAACGAGCGAGGAGCACGGCCAGCTTCGGGGCCGTCGTGACCACAGGAGGGC
AGAGGGCCAGCCCGTGAGCTCTGACCCCAGCTGGACGTGCTCTTGTTTCCCTTGGGGCTAAGGAGATTGGAGCCACTGAACTGAATCTCT
GGGTTTTGGAGACTTAGAGAATCCATTGGACTCTTCTGCTGGCGTCTTTCTGAATGCTGATGGGGACTTGGTGACTTCAGCTACGGGACG
GACGAGTACGACGGAGAGGGGAATGAGGAGCAGAAGGGGCCCCCGGAGGGCTCAGAGACCATGCCGTACATCGATGAGTCGCCCACCATG
TCCCCGCAGCTCAGCGCCCGCAGCCAGGGCGGGGGGGATGGCGTCTCCCCGACTCCACCTGAGGGACTGGCTCCTGGGGTGGAAGCAGGG
AAAGGCCTGGAGATGAGGAAGCTGGTTCTCTCGGGGTTCTTGGCCAGCGAAGAGATCTACATTAACCAGCTGGAAGCCCTGTTGCTGCCC
ATGAAACCCCTGAAGGCCACCGCCACCACCTCCCAGCCCGTGCTCACCATCCAGCAGATCGAGACCATCTTCTACAAGATCCAGGACATC
TATGAGATCCACAAGGAGTTCTATGACAACCTGTGCCCCAAGGTGCAACAGTGGGACAGCCAGGTCACCATGGGCCACCTCTTCCAGAAG
CTGGCCAGCCAGCTCGGTGTGTACAAAGCGTTTGTCGATAACTATAAAGTCGCTCTGGAGACAGCTGAGAAGTGCAGCCAGTCCAACAAC
CAGTTCCAGAAGATCTCAGAGGAACTCAAAGTGAAAGGTCCCAAGGACTCCAAGGACAGCCACACGTCTGTCACCATGGAAGCTCTGCTC
TACAAGCCCATTGACCGGGTCACTCGGAGCACCCTAGTCCTACACGACCTGCTGAAGCACACACCTGTGGACCACCCCGACTACCCGCTG
CTGCAGGATGCCCTCCGCATCTCCCAGAACTTCCTGTCCAGCATCAACGAGGACATCGACCCCCGCCGGACTGCAGTGACAACGCCCAAG
GGGGAGACGCGACAGCTGGTGAAGGACGGCTTCCTGGTGGAAGTGTCAGAGAGCTCCCGGAAGCTGCGGCACGTCTTCCTCTTTACAGAT
GTCCTACTGTGTGCCAAGCTGAAGAAGACCTCTGCAGGGAAGCACCAGCAGTATGACTGTAAGTGGTACATCCCCCTGGCCGACCTGGTG
TTTCCATCCCCCGAGGAGTCTGAGGCCAGCCCCCAGGTGCACCCCTTCCCAGACCATGAGCTGGAGGACATGAAGATGAAGATCTCTGCC
CTCAAGAGTGAAATCCAGAAGGAGAAAGCCAACAAAGGCCAGAGCCGGGCCATCGAGCGCCTGAAGAAGAAGATGTTTGAGAATGAGTTC
CTGCTGCTGCTCAACTCCCCCACAATCCCGTTCAGGATCCACAATCGGAATGGAAAGAGTTACCTGTTCCTACTGTCCTCGGACTACGAG
AGGTCAGAGTGGAGAGAAGCAATTCAGAAACTACAGAAGAAGGATCTCCAGGCCTTTGTCCTGAGCTCAGTGGAGCTCCAGGTGCTCACA
GGATCCTGTTTCAAGCTTAGGACTGTACACAACATTCCTGTCACCAGCAATAAAGACGACGATGAGTCTCCAGGACTCTATGGCTTCCTT
CATGTCATCGTCCACTCTGCCAAGGGATTTAAGCAATCAGCCAACCTGTACTGTACCCTGGAGGTGGATTCCTTCGGCTATTTTGTCAGC
AAAGCCAAAACCAGGGTGTTCCGGGACACAGCGGAGCCCAAGTGGGATGAGGAGTTTGAGATCGAGCTGGAGGGCTCCCAGTCCCTGAGG
ATCCTGTGCTATGAGAAGTGCTATGACAAGACCAAGGTCAACAAGGACAACAATGAGATCGTGGACAAGATCATGGGCAAAGGACAGATC
CAGGAAGCGGCTCAGCCCCAGGGCAGCACATCAGAGACACCATGGAACACAGCCATTCCTCTGCCGTCGTGCTGGGACCAGTCTTTCCTG
ACCAATATCACCTTCTTGAAGGTTCTTCTCTGGTTGGTCCTGCTGGGACTGTTTGTGGAACTGGAATTTGGCCTGGCATATTTTGTCCTG
TCCTTGTTCTATTGGATGTACGTCGGGACACGAGGCCCTGAAGAGAAGAAAGAGGGAGAGAAGAGCGCCTACTCTGTGTTCAATCCAGGC
TGTGAAGCCATCCAGGGCACCCTGACTGCAGAGCAGTTGGAGCGCGAGTTACAGTTGAGACCCCTGGCAGGGAGATAGGACCCAGCTGTG
CTGTCATGCAGCTAACCTCTGATGTGGTCTTCCTCACCATTGGCTATGGATTTGATTTCAGGTGTATAGGACTAAGGGCAGCTTGCGGGT
TAGCTCTGTGACTGCATAGTTTTTCTACCTTCTTTCCCTGATCTTTTGCTGCCATTTGATCTTTGATAGTTTTGGTGAAACTCTCTAAAA
TACATTCACTGTGGGTCCGACGCAATTTATAAAAATTATGTACTCAAGAAGGGAGACCTGTTTGTTTCATTTCTCATCTGTTTGGGAGAT
GATTTTAGAGCACTAGAAAGGCACTGGGGAGATTCTCAGCTTAAAACATCCAGCAGTTTGAAGTATGATTAGGTACATCAGGGCTGCATT
GTCAATGTTCTCTTTAAGTCTTTTAACATTTATAGCAATTTTTTTTTTCCCGGAGAGTTTAGGTTGCAAGTTTTGGGTTTCTTGTTTGTT
TTTGTTTTGCTTCCTGCTTTAATTCTTTAATTTTCAGTCATTACTGGTATTGAAAAATAAAATATCTTTAAAACATCTCCTCTTCAGAAA
TAGGTCCCTCTTCATTGCCCATCACCATCTTCCACTCTCCTATTATTTTGCCACTACTCAGTAAAGGAAGGTAGGAAGAGACAAACGCCT
AAGTGCAGGTGTGGGGAGGGATTTCACAAGTGGTTATTAACGGCCAGTTCAGCAAGAAGTGTTGAGTGTGTACAAAGGGGAGGGCTGGAA
GTGTTAACTCCAGACCCGTTGGCTGCTTGAGTTGTTTCTTATATTCTAAAGCAGCAGTCCCTAACCTTTTTGGCACCAGGGACCAGTTTT
GTGGAACACAGTTTTTCCATGGACGGGGTGGTGGTGGAGGATGAAACTTCCACCTCAGATCATCAGGCATTAGAGTCTCATAAGGAGCAC
GCAACCTAGATCCCTCGCATGCGCAGTTCACAATACGGTTCTAAGGGCTTTAGAGTAAGCAGCTTTTTCACCTGTGGGCCTCTGGTGAGA
AATTCTGTAAATTGTGATAATCAGGCTGGATTTTAATGCTGCTTTTCCAGTACAATGTTAGAGTTTGGGTTCATTAAAATTAGGCAAACT
CCCATTGGGTTAGGGCTTCTCTCATTCCATTTTGTGGCTAACCTTACTGTGTTTCAGCCCTTGCTGAAAATTCTTCTGATATGTGTTGCC
CTTCCTCACAGCCCTTTGGCCATTGGGAGTTTGGCTGTCCCTCAGAGCCATCCGGTCAAGCAGATGGTCTGTTCTATCTCACAGAAAAGT
CTTTTCTTCCATGAGTTCTGTCTGAACTGAACATGTAAAAAGTATGGGAAACAGATGAATCCCTATTAAACATGAAGTTTTGATTGTATT

>In-frame_ENST00000544583_ENST00000229903_5263N_ABR_chr17_953289_-_SAYSD1_chr6_39073552_length(amino acids)=665AA_start in transcript=600_stop in transcript=2597
MPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQI
ETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDS
HTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSR
KLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIER
LKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDD
DESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEI
VDKIMGKGQIQEAAQPQGSTSETPWNTAIPLPSCWDQSFLTNITFLKVLLWLVLLGLFVELEFGLAYFVLSLFYWMYVGTRGPEEKKEGE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ABR-SAYSD1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ABR-SAYSD1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ABR-SAYSD1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ABR	C0033578	Prostatic Neoplasms	1	CTD_human
Hgene	ABR	C0376358	Malignant neoplasm of prostate	1	CTD_human