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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PRDM6-NIPAL4 (FusionGDB2 ID:68026)

Fusion Gene Summary for PRDM6-NIPAL4

check button Fusion gene summary
Fusion gene informationFusion gene name: PRDM6-NIPAL4
Fusion gene ID: 68026
HgeneTgene
Gene symbol

PRDM6

NIPAL4

Gene ID

93166

348938

Gene namePR/SET domain 6NIPA like domain containing 4
SynonymsKMT8C|PDA3|PRISMARCI6|ICHTHYIN|ICHYN
Cytomap

5q23.2

5q33.3

Type of geneprotein-codingprotein-coding
Descriptionputative histone-lysine N-methyltransferase PRDM6PR domain 6PR domain containing 6PR domain-containing protein 6PR-domain zinc finger protein 6magnesium transporter NIPA4NIPA-like protein 4non-imprinted in Prader-Willi/Angelman syndrome region protein 4
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000407847, ENST00000464424, 
ENST00000435489, ENST00000311946, 
ENST00000521390, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 1 X 1=2
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/2*10)=2.32192809488736
Context

PubMed: PRDM6 [Title/Abstract] AND NIPAL4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPRDM6(122495332)-NIPAL4(156890102), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PRDM6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NIPAL4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-BP-4986-01APRDM6chr5

122495332

+NIPAL4chr5

156890102

+
ChimerDB4KIRCTCGA-BP-4986-01APRDM6chr5

122495332

+NIPAL4chr5

156890102

+
ChimerDB4KIRCTCGA-BP-4986-01APRDM6chr5

122495332

-NIPAL4chr5

156890102

+


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Fusion Gene ORF analysis for PRDM6-NIPAL4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000407847ENST00000435489PRDM6chr5

122495332

+NIPAL4chr5

156890102

+
In-frameENST00000407847ENST00000311946PRDM6chr5

122495332

+NIPAL4chr5

156890102

+
5CDS-3UTRENST00000407847ENST00000521390PRDM6chr5

122495332

+NIPAL4chr5

156890102

+
intron-3CDSENST00000464424ENST00000435489PRDM6chr5

122495332

+NIPAL4chr5

156890102

+
intron-3CDSENST00000464424ENST00000311946PRDM6chr5

122495332

+NIPAL4chr5

156890102

+
intron-3UTRENST00000464424ENST00000521390PRDM6chr5

122495332

+NIPAL4chr5

156890102

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000407847PRDM6chr5122495332+ENST00000435489NIPAL4chr5156890102+282815672462687813
ENST00000407847PRDM6chr5122495332+ENST00000311946NIPAL4chr5156890102+450215672462744832

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000407847ENST00000435489PRDM6chr5122495332+NIPAL4chr5156890102+0.0139648740.9860351
ENST00000407847ENST00000311946PRDM6chr5122495332+NIPAL4chr5156890102+0.0093528640.99064714

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Fusion Genomic Features for PRDM6-NIPAL4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PRDM6chr5122495332+NIPAL4chr5156890101+0.0001138440.99988616
PRDM6chr5122495332+NIPAL4chr5156890101+0.0001138440.99988616

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PRDM6-NIPAL4


check button Go to

FGviewer for the breakpoints of chr5:122495332-chr5:156890102

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRDM6chr5:122495332chr5:156890102ENST00000407847+58123_129384.3333333333333596.0Compositional biasNote=Poly-Ala
HgenePRDM6chr5:122495332chr5:156890102ENST00000407847+58151_162384.3333333333333596.0Compositional biasNote=Poly-Gly
HgenePRDM6chr5:122495332chr5:156890102ENST00000407847+58228_232384.3333333333333596.0Compositional biasNote=Poly-Ala
HgenePRDM6chr5:122495332chr5:156890102ENST00000407847+5847_73384.3333333333333596.0Compositional biasNote=Pro-rich
HgenePRDM6chr5:122495332chr5:156890102ENST00000407847+5897_106384.3333333333333596.0Compositional biasNote=Poly-Ala
HgenePRDM6chr5:122495332chr5:156890102ENST00000407847+58246_365384.3333333333333596.0DomainSET
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000031194606139_16474.33333333333333467.0Topological domainCytoplasmic
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000031194606186_18674.33333333333333467.0Topological domainExtracellular
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000031194606208_21574.33333333333333467.0Topological domainCytoplasmic
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000031194606237_25774.33333333333333467.0Topological domainExtracellular
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000031194606279_28574.33333333333333467.0Topological domainCytoplasmic
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000031194606307_32374.33333333333333467.0Topological domainExtracellular
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000031194606345_35574.33333333333333467.0Topological domainCytoplasmic
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000031194606377_38674.33333333333333467.0Topological domainExtracellular
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000031194606408_46674.33333333333333467.0Topological domainCytoplasmic
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000043548905139_16474.33333333333333448.0Topological domainCytoplasmic
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000043548905186_18674.33333333333333448.0Topological domainExtracellular
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000043548905208_21574.33333333333333448.0Topological domainCytoplasmic
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000043548905237_25774.33333333333333448.0Topological domainExtracellular
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000043548905279_28574.33333333333333448.0Topological domainCytoplasmic
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000043548905307_32374.33333333333333448.0Topological domainExtracellular
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000043548905345_35574.33333333333333448.0Topological domainCytoplasmic
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000043548905377_38674.33333333333333448.0Topological domainExtracellular
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000043548905408_46674.33333333333333448.0Topological domainCytoplasmic
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000031194606118_13874.33333333333333467.0TransmembraneHelical
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000031194606165_18574.33333333333333467.0TransmembraneHelical
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000031194606187_20774.33333333333333467.0TransmembraneHelical
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000031194606216_23674.33333333333333467.0TransmembraneHelical
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000031194606258_27874.33333333333333467.0TransmembraneHelical
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000031194606286_30674.33333333333333467.0TransmembraneHelical
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000031194606324_34474.33333333333333467.0TransmembraneHelical
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000031194606356_37674.33333333333333467.0TransmembraneHelical
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000031194606387_40774.33333333333333467.0TransmembraneHelical
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000043548905118_13874.33333333333333448.0TransmembraneHelical
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000043548905165_18574.33333333333333448.0TransmembraneHelical
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000043548905187_20774.33333333333333448.0TransmembraneHelical
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000043548905216_23674.33333333333333448.0TransmembraneHelical
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000043548905258_27874.33333333333333448.0TransmembraneHelical
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000043548905286_30674.33333333333333448.0TransmembraneHelical
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000043548905324_34474.33333333333333448.0TransmembraneHelical
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000043548905356_37674.33333333333333448.0TransmembraneHelical
TgeneNIPAL4chr5:122495332chr5:156890102ENST0000043548905387_40774.33333333333333448.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRDM6chr5:122495332chr5:156890102ENST00000407847+58473_495384.3333333333333596.0Zinc fingerC2H2-type 1%3B degenerate
HgenePRDM6chr5:122495332chr5:156890102ENST00000407847+58501_523384.3333333333333596.0Zinc fingerC2H2-type 2
HgenePRDM6chr5:122495332chr5:156890102ENST00000407847+58529_551384.3333333333333596.0Zinc fingerC2H2-type 3
HgenePRDM6chr5:122495332chr5:156890102ENST00000407847+58557_579384.3333333333333596.0Zinc fingerC2H2-type 4%3B degenerate
TgeneNIPAL4chr5:122495332chr5:156890102ENST00000311946061_11774.33333333333333467.0Topological domainExtracellular
TgeneNIPAL4chr5:122495332chr5:156890102ENST00000435489051_11774.33333333333333448.0Topological domainExtracellular


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Fusion Gene Sequence for PRDM6-NIPAL4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000407847_ENST00000435489_TCGA-BP-4986-01A_PRDM6_chr5_122495332_+_NIPAL4_chr5_156890102_length(transcript)=2828nt_BP=1567nt
CTCTCTCACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACTCACTCTATTTTGTGCTGT
CGTAAAACCCACGTGTCCAGCCGGGAAGCTGCCAGAGCGTGGAACCAAGGAGCCAGGACGCGGCAGCGGCCAAGCGCAGCAGCCCACGGC
GGTTGAGTCGGGCGCCCAGGTCCGTCCGCACTCTCGCGCCCTCCGCGGGCCTCCCAATTTTCTCGCTTGCAGGTCGGGAGGTTTCCGGGC
GGCACAATCTCTAGGACTCTCCTCCCGCGCTGCTCAGGGGCATGTAGCGCACGCAGGGCGCACACTCTCGCGCACCCGCACGCTCACCGA
GACACCCGCACGCACCCACCGGCAGCACCGAGTTTTCAGTTCGAGGCGCCGGACATGCTGAAGCCCGGAGACCCCGGCGGTTCGGCCTTC
CTCAAAGTGGACCCAGCCTACCTGCAGCACTGGCAGCAACTCTTCCCTCACGGAGGCGCAGGCCCGCTCAAGGGCAGCGGCGCCGCGGGT
CTCCTGAGCGCGCCGCAGCCTCTTCAGCCGCCGCCGCCGCCCCCGCCCCCGGAGCGCGCTGAGCCTCCGCCGGACAGCCTGCGCCCGCGG
CCCGCCTCTCTCTCCTCCGCCTCGTCCACGCCGGCTTCCTCTTCCACCTCCGCCTCCTCCGCCTCCTCCTGCGCTGCTGCGGCCGCTGCC
GCCGCGCTGGCTGGTCTCTCGGCCCTGCCGGTGTCGCAGCTGCCGGTGTTCGCGCCTCTAGCCGCCGCTGCCGTCGCCGCCGAGCCGCTG
CCCCCCAAGGAACTGTGCCTCGGCGCCACCTCCGGCCCCGGGCCCGTCAAGTGCGGTGGTGGTGGCGGCGGCGGCGGGGAGGGTCGCGGC
GCCCCGCGCTTCCGCTGCAGCGCAGAGGAGCTGGACTATTACCTGTATGGCCAGCAGCGCATGGAGATCATCCCGCTCAACCAGCACACC
AGCGACCCCAACAACCGTTGCGACATGTGCGCGGACAACCGCAACGGCGAGTGCCCTATGCATGGGCCACTGCACTCGCTGCGCCGGCTT
GTGGGCACCAGCAGCGCTGCGGCCGCCGCGCCCCCGCCGGAGCTGCCGGAGTGGCTGCGGGACCTGCCTCGCGAGGTGTGCCTCTGCACC
AGTACTGTGCCCGGCCTGGCCTACGGCATCTGCGCGGCGCAGAGGATCCAGCAAGGCACCTGGATTGGACCTTTCCAAGGCGTGCTTCTG
CCCCCAGAGAAGGTGCAGGCAGGCGCCGTGAGGAACACGCAGCATCTCTGGGAGATATATGACCAGGATGGGACACTACAGCACTTTATT
GATGGTGGGGAACCTAGTAAGTCGAGCTGGATGAGGTATATCCGATGTGCAAGGCACTGCGGAGAACAGAATCTAACAGTAGTTCAGTAC
AGGTCGAATATATTCTACCGAGCCTGTATAGATATCCCTAGGGGCACCGAGCTTCTGGTGTGGTACAATGACAGCTATACGTCTTTCTTT
GGGATCCCCTTACAATGCATTGCCCAGGATGAAAACTGTTCCCTGCTCCACCTCTACTGCTCCTCCCAAGAAGTCCTGTGCCAGATTGTC
AATGACCTCAGCCCTGAGGTGCCCAGCAATGCCACCTTTCACAGCTGGCAGGAAAGAATCAGGCAGAACTATGGCTTCTACATCGGCCTG
GGCCTGGCATTCCTGTCTAGCTTCCTCATCGGCAGCAGCGTCATCCTCAAGAAGAAAGGCCTCTTGCGACTCGTGGCCACGGGAGCCACT
CGAGCTGTGGCTGCTGGAGAAGTTGCCAACTTTGGAGCCTACGCATTTGCACCTGCAACAGTCGTCACGCCTCTGGGAGCGCTGAGTGTC
CTCATAAGTGCCATCCTCTCCTCATATTTCCTGAGGGAGAGTCTGAACCTGCTGGGGAAGCTGGGCTGTGTGATCTGTGTGGCCGGAAGC
ACAGTGATGGTGATACATGCTCCTGAGGAAGAGAAGGTCACTACCATCATGGAGATGGCTTCCAAGATGAAAGACACAGGGTTCATCGTG
TTTGCTGTGCTTCTGCTGGTGTCATGCCTCATCCTCATCTTTGTCATTGCCCCACGTTACGGGCAAAGGAATATCCTCATCTACATCATC
ATCTGCTCTGTGATCGGGGCCTTCTCTGTGGCTGCTGTCAAGGGGCTGGGCATCACCATCAAGAACTTCTTCCAGGGGCTGCCAGTTGTC
CGGCACCCGCTCCCCTACATCCTGTCCCTCATCCTGGCACTGTCCCTCAGCACTCAGGTCAACTTCCTCAACAGAGCACTGGACATTTTC
AACACTTCCCTGGTGTTCCCCATCTACTACGTGTTCTTCACCACGGTGGTCGTTACCTCGTCCATCATCCTCTTCAAGGAGTGGTACAGC
ATGTCTGCTGTGGACATTGCAGGCACCCTCTCGGGCTTTGTCACCATCATCTTGGGCGTGTTCATGCTGCATGCTTTCAAAGACCTGGAC
ATCAGCTGCGCCAGCTTGCCCCACATGCACAAAAACCCACCCCCTTCTCCCGCCCCGGAACCCACTGTTATTAGACTGGAAGACAAGAAC
GTCCTTGTGGACAATATAGAACTTGCCAGCACCTCATCACCAGAAGAGAAACCCAAAGTATTTATAATCCATTCCTGAAGCTTGGAATAT
GTGAGTGAGAGGATGAGTCCGATGGTACAGCCTGCCCTCCCAATTTCAAAACCACCTGGTTATTTTCCAGTGCAACTGTTACCAATGGGC

>In-frame_ENST00000407847_ENST00000435489_TCGA-BP-4986-01A_PRDM6_chr5_122495332_+_NIPAL4_chr5_156890102_length(amino acids)=813AA_start in transcript=246_stop in transcript=2687
MQVGRFPGGTISRTLLPRCSGACSARRAHTLAHPHAHRDTRTHPPAAPSFQFEAPDMLKPGDPGGSAFLKVDPAYLQHWQQLFPHGGAGP
LKGSGAAGLLSAPQPLQPPPPPPPPERAEPPPDSLRPRPASLSSASSTPASSSTSASSASSCAAAAAAAALAGLSALPVSQLPVFAPLAA
AAVAAEPLPPKELCLGATSGPGPVKCGGGGGGGGEGRGAPRFRCSAEELDYYLYGQQRMEIIPLNQHTSDPNNRCDMCADNRNGECPMHG
PLHSLRRLVGTSSAAAAAPPPELPEWLRDLPREVCLCTSTVPGLAYGICAAQRIQQGTWIGPFQGVLLPPEKVQAGAVRNTQHLWEIYDQ
DGTLQHFIDGGEPSKSSWMRYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVWYNDSYTSFFGIPLQCIAQDENCSLLHLYCSS
QEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVAAGEVANFGAYAFAPATVV
TPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAVLLLVSCLILIFVIAPRYGQ
RNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDIFNTSLVFPIYYVFFTTVVVTSSI
ILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIRLEDKNVLVDNIELASTSSPEEKPKVFI

--------------------------------------------------------------
>In-frame_ENST00000407847_ENST00000311946_TCGA-BP-4986-01A_PRDM6_chr5_122495332_+_NIPAL4_chr5_156890102_length(transcript)=4502nt_BP=1567nt
CTCTCTCACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACACTCACTCTATTTTGTGCTGT
CGTAAAACCCACGTGTCCAGCCGGGAAGCTGCCAGAGCGTGGAACCAAGGAGCCAGGACGCGGCAGCGGCCAAGCGCAGCAGCCCACGGC
GGTTGAGTCGGGCGCCCAGGTCCGTCCGCACTCTCGCGCCCTCCGCGGGCCTCCCAATTTTCTCGCTTGCAGGTCGGGAGGTTTCCGGGC
GGCACAATCTCTAGGACTCTCCTCCCGCGCTGCTCAGGGGCATGTAGCGCACGCAGGGCGCACACTCTCGCGCACCCGCACGCTCACCGA
GACACCCGCACGCACCCACCGGCAGCACCGAGTTTTCAGTTCGAGGCGCCGGACATGCTGAAGCCCGGAGACCCCGGCGGTTCGGCCTTC
CTCAAAGTGGACCCAGCCTACCTGCAGCACTGGCAGCAACTCTTCCCTCACGGAGGCGCAGGCCCGCTCAAGGGCAGCGGCGCCGCGGGT
CTCCTGAGCGCGCCGCAGCCTCTTCAGCCGCCGCCGCCGCCCCCGCCCCCGGAGCGCGCTGAGCCTCCGCCGGACAGCCTGCGCCCGCGG
CCCGCCTCTCTCTCCTCCGCCTCGTCCACGCCGGCTTCCTCTTCCACCTCCGCCTCCTCCGCCTCCTCCTGCGCTGCTGCGGCCGCTGCC
GCCGCGCTGGCTGGTCTCTCGGCCCTGCCGGTGTCGCAGCTGCCGGTGTTCGCGCCTCTAGCCGCCGCTGCCGTCGCCGCCGAGCCGCTG
CCCCCCAAGGAACTGTGCCTCGGCGCCACCTCCGGCCCCGGGCCCGTCAAGTGCGGTGGTGGTGGCGGCGGCGGCGGGGAGGGTCGCGGC
GCCCCGCGCTTCCGCTGCAGCGCAGAGGAGCTGGACTATTACCTGTATGGCCAGCAGCGCATGGAGATCATCCCGCTCAACCAGCACACC
AGCGACCCCAACAACCGTTGCGACATGTGCGCGGACAACCGCAACGGCGAGTGCCCTATGCATGGGCCACTGCACTCGCTGCGCCGGCTT
GTGGGCACCAGCAGCGCTGCGGCCGCCGCGCCCCCGCCGGAGCTGCCGGAGTGGCTGCGGGACCTGCCTCGCGAGGTGTGCCTCTGCACC
AGTACTGTGCCCGGCCTGGCCTACGGCATCTGCGCGGCGCAGAGGATCCAGCAAGGCACCTGGATTGGACCTTTCCAAGGCGTGCTTCTG
CCCCCAGAGAAGGTGCAGGCAGGCGCCGTGAGGAACACGCAGCATCTCTGGGAGATATATGACCAGGATGGGACACTACAGCACTTTATT
GATGGTGGGGAACCTAGTAAGTCGAGCTGGATGAGGTATATCCGATGTGCAAGGCACTGCGGAGAACAGAATCTAACAGTAGTTCAGTAC
AGGTCGAATATATTCTACCGAGCCTGTATAGATATCCCTAGGGGCACCGAGCTTCTGGTGTGGTACAATGACAGCTATACGTCTTTCTTT
GGGATCCCCTTACAATGCATTGCCCAGGATGAAAACTGTTCCCTGCTCCACCTCTACTGCTCCTCCCAAGAAGTCCTGTGCCAGATTGTC
AATGACCTCAGCCCTGAGGTGCCCAGCAATGCCACCTTTCACAGCTGGCAGGAAAGAATCAGGCAGAACTATGGCTTCTACATCGGCCTG
GGCCTGGCATTCCTGTCTAGCTTCCTCATCGGCAGCAGCGTCATCCTCAAGAAGAAAGGCCTCTTGCGACTCGTGGCCACGGGAGCCACT
CGAGCTGTGGATGGAGGCTTCGGCTACCTGAAAGATGCAATGTGGTGGGCTGGATTTCTCACCATGGCTGCTGGAGAAGTTGCCAACTTT
GGAGCCTACGCATTTGCACCTGCAACAGTCGTCACGCCTCTGGGAGCGCTGAGTGTCCTCATAAGTGCCATCCTCTCCTCATATTTCCTG
AGGGAGAGTCTGAACCTGCTGGGGAAGCTGGGCTGTGTGATCTGTGTGGCCGGAAGCACAGTGATGGTGATACATGCTCCTGAGGAAGAG
AAGGTCACTACCATCATGGAGATGGCTTCCAAGATGAAAGACACAGGGTTCATCGTGTTTGCTGTGCTTCTGCTGGTGTCATGCCTCATC
CTCATCTTTGTCATTGCCCCACGTTACGGGCAAAGGAATATCCTCATCTACATCATCATCTGCTCTGTGATCGGGGCCTTCTCTGTGGCT
GCTGTCAAGGGGCTGGGCATCACCATCAAGAACTTCTTCCAGGGGCTGCCAGTTGTCCGGCACCCGCTCCCCTACATCCTGTCCCTCATC
CTGGCACTGTCCCTCAGCACTCAGGTCAACTTCCTCAACAGAGCACTGGACATTTTCAACACTTCCCTGGTGTTCCCCATCTACTACGTG
TTCTTCACCACGGTGGTCGTTACCTCGTCCATCATCCTCTTCAAGGAGTGGTACAGCATGTCTGCTGTGGACATTGCAGGCACCCTCTCG
GGCTTTGTCACCATCATCTTGGGCGTGTTCATGCTGCATGCTTTCAAAGACCTGGACATCAGCTGCGCCAGCTTGCCCCACATGCACAAA
AACCCACCCCCTTCTCCCGCCCCGGAACCCACTGTTATTAGACTGGAAGACAAGAACGTCCTTGTGGACAATATAGAACTTGCCAGCACC
TCATCACCAGAAGAGAAACCCAAAGTATTTATAATCCATTCCTGAAGCTTGGAATATGTGAGTGAGAGGATGAGTCCGATGGTACAGCCT
GCCCTCCCAATTTCAAAACCACCTGGTTATTTTCCAGTGCAACTGTTACCAATGGGCTCTCTTTTCTTGAGAAGTTCATTTATACCTCAT
CACTGTTTCCAGGAGAAAAATCTTTACCCAAATAGCAATGGTGGCAGAACTTCCTGGAAACAGATTCAGTGACCAAATACCCAAGTTTAC
ATCAGTGCCTGCAGGTTCCCTGGACCTTCCTTCTCATTCATTCTTTCGGTGCCATCTCTATGCCGTTGGGAAGAAGATGGAGTCTGACCC
ACTGAATGTAGCACAGTCCAAGGACTTCTCTAAGATATTGGTCATTGGAAGTTCCTTCACACCAATTCTCCTCCTGAGACGGAATCTCCG
TTGTTGTTGTTGTTGTTGTTTTCTAGCCCAAGGATGACATAGAGCTGGCTCCCAGAGGCCCACAGAGCAATTGGCCATGCCTCCCTATCC
AGAGCTGACAGGGACACAACCAGTGTAAAATATCCTGTTGCCTTTGTCACTTCCTCTTTGGAGGCAGAAGCAAGACCTCAGCTGACCTTC
TTACTGTGAAAGCCACTTGATGTCTCAGGGAAAAATTTCAACCAGCTCATTCCCCGAGCACTCCAGCCTGGCAGTCAGCACCTCGGCATC
CACCCAGTCCATCCCACCATCACCCCTTCCCCCTCTACTTACATCCTAAGGAGTCGGTCACTGAGACATAAAGGCAGTAATCGCAGAACT
GGAAACAAAACAATAATAGAGCCACAGCCAAACTCTGGTGGCCAAACCCAGTGTTGCATTTTGTCTTACTCTGAAAGAAGAACAGCAAAT
TCACTGCTTCAAAGTGGCCTGGCTGCCAAGCTAGAATTTGGCAGAACGCACTTTACTATTCCTCAAGGAGTCAACCAACCTATGATCTGG
GGAGGTGGGAAGAGGATGAGGAGCAAAGTTGGGATTTGGCAGAAGGCAGTCCCAGGCTCTCTGGATACTAGGGGCTAACTTTTGTGTTGA
CTCTGGTGCTCATCTGGGAACTTAGGAGAAACGAGCTCAGGGGTAATTTCTGGGTTGCAGCCTTAAAGGCTTGGACAGCTGTGAATCTCA
ATGGCCAACTGGAGGTGCAGACTTGGCATGGGGTGCATTCTAGCTGTTGACCAGATTGCTACCGAGTCCCCTCCTCCACTGATGAGCTGC
CCACACTGGGAAGCAGCATGCCCTGACTGTTCCAACACCACCTGCTATGGGGAGTACCTTTGGTCCCCTCACATTTGGCCAGAGGCATAC
AAAAAACCAGAGCAGCTGGAGAGGGAGATAATTACTATTCCTTCCCTTCCTATCTCCTTTCTAGCCACAAGAGTGTGGGGGTTGGAGAAG
AACCATTAGAAAGGGAAATTAGTGGGCTGGTGTATCTGGAAAGAGGGAAGACTTGATCCTCAGCCCCGAGGTTGGTGCAGGGCCTCCCCT
GTGTGACTCTACCTGCACTCTGTGTTTATATCCTGTGCCCTAAGTGGGCCAAGCCCAGGTAAATTCCTGCTGGCCTTGGAACTCCAAGGT
TTGGCTGACCAGCAGACTGGCTCCCTGACTCTTCAGCCTCAAATCCCCAGTTTTTGATGAATGTGGATTTCTGTCTGTAATTAAAAGCAA
TGCAACAAGTTGGCTCTTGAGAATGGCAGTAAACTGAGGGCCCTAAGAGTGTGGTCTGCAGGGTCAAGAATAAAGATTACAGATTATATT

>In-frame_ENST00000407847_ENST00000311946_TCGA-BP-4986-01A_PRDM6_chr5_122495332_+_NIPAL4_chr5_156890102_length(amino acids)=832AA_start in transcript=246_stop in transcript=2744
MQVGRFPGGTISRTLLPRCSGACSARRAHTLAHPHAHRDTRTHPPAAPSFQFEAPDMLKPGDPGGSAFLKVDPAYLQHWQQLFPHGGAGP
LKGSGAAGLLSAPQPLQPPPPPPPPERAEPPPDSLRPRPASLSSASSTPASSSTSASSASSCAAAAAAAALAGLSALPVSQLPVFAPLAA
AAVAAEPLPPKELCLGATSGPGPVKCGGGGGGGGEGRGAPRFRCSAEELDYYLYGQQRMEIIPLNQHTSDPNNRCDMCADNRNGECPMHG
PLHSLRRLVGTSSAAAAAPPPELPEWLRDLPREVCLCTSTVPGLAYGICAAQRIQQGTWIGPFQGVLLPPEKVQAGAVRNTQHLWEIYDQ
DGTLQHFIDGGEPSKSSWMRYIRCARHCGEQNLTVVQYRSNIFYRACIDIPRGTELLVWYNDSYTSFFGIPLQCIAQDENCSLLHLYCSS
QEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKKGLLRLVATGATRAVDGGFGYLKDAMWWAGFLTM
AAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAV
LLLVSCLILIFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDIFNTS
LVFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHMHKNPPPSPAPEPTVIRLEDKNVLV

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Fusion Gene PPI Analysis for PRDM6-NIPAL4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PRDM6-NIPAL4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PRDM6-NIPAL4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePRDM6C4310753PATENT DUCTUS ARTERIOSUS 31GENOMICS_ENGLAND;UNIPROT
TgeneNIPAL4C2677065ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 63CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneNIPAL4C0079154Congenital Nonbullous Ichthyosiform Erythroderma2GENOMICS_ENGLAND;ORPHANET