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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PRELID2-MEGF10 (FusionGDB2 ID:68078)

Fusion Gene Summary for PRELID2-MEGF10

check button Fusion gene summary
Fusion gene informationFusion gene name: PRELID2-MEGF10
Fusion gene ID: 68078
HgeneTgene
Gene symbol

PRELID2

MEGF10

Gene ID

153768

84466

Gene namePRELI domain containing 2multiple EGF like domains 10
Synonyms-EMARDD|SR-F3
Cytomap

5q32

5q23.2

Type of geneprotein-codingprotein-coding
DescriptionPRELI domain-containing protein 2CTC-806A22.1multiple epidermal growth factor-like domains protein 10
Modification date2020031320200313
UniProtAcc.

Q96KG7

Ensembl transtripts involved in fusion geneENST00000510594, ENST00000334744, 
ENST00000358004, ENST00000394450, 
ENST00000505416, ENST00000511435, 
ENST00000503335, ENST00000508365, 
ENST00000418761, ENST00000274473, 
ENST00000510828, 
Fusion gene scores* DoF score4 X 5 X 4=802 X 3 X 2=12
# samples 53
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PRELID2 [Title/Abstract] AND MEGF10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPRELID2(145144494)-MEGF10(126769055), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMEGF10

GO:0034109

homotypic cell-cell adhesion

22407321


check buttonFusion gene breakpoints across PRELID2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MEGF10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-77-A5GA-01APRELID2chr5

145144494

-MEGF10chr5

126769055

+


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Fusion Gene ORF analysis for PRELID2-MEGF10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000510594ENST00000503335PRELID2chr5

145144494

-MEGF10chr5

126769055

+
5UTR-intronENST00000510594ENST00000508365PRELID2chr5

145144494

-MEGF10chr5

126769055

+
5UTR-intronENST00000510594ENST00000418761PRELID2chr5

145144494

-MEGF10chr5

126769055

+
5UTR-intronENST00000510594ENST00000274473PRELID2chr5

145144494

-MEGF10chr5

126769055

+
5UTR-intronENST00000510594ENST00000510828PRELID2chr5

145144494

-MEGF10chr5

126769055

+
3UTR-3CDSENST00000334744ENST00000503335PRELID2chr5

145144494

-MEGF10chr5

126769055

+
3UTR-intronENST00000334744ENST00000508365PRELID2chr5

145144494

-MEGF10chr5

126769055

+
3UTR-intronENST00000334744ENST00000418761PRELID2chr5

145144494

-MEGF10chr5

126769055

+
3UTR-intronENST00000334744ENST00000274473PRELID2chr5

145144494

-MEGF10chr5

126769055

+
3UTR-intronENST00000334744ENST00000510828PRELID2chr5

145144494

-MEGF10chr5

126769055

+
3UTR-3CDSENST00000358004ENST00000503335PRELID2chr5

145144494

-MEGF10chr5

126769055

+
3UTR-intronENST00000358004ENST00000508365PRELID2chr5

145144494

-MEGF10chr5

126769055

+
3UTR-intronENST00000358004ENST00000418761PRELID2chr5

145144494

-MEGF10chr5

126769055

+
3UTR-intronENST00000358004ENST00000274473PRELID2chr5

145144494

-MEGF10chr5

126769055

+
3UTR-intronENST00000358004ENST00000510828PRELID2chr5

145144494

-MEGF10chr5

126769055

+
3UTR-3CDSENST00000394450ENST00000503335PRELID2chr5

145144494

-MEGF10chr5

126769055

+
3UTR-intronENST00000394450ENST00000508365PRELID2chr5

145144494

-MEGF10chr5

126769055

+
3UTR-intronENST00000394450ENST00000418761PRELID2chr5

145144494

-MEGF10chr5

126769055

+
3UTR-intronENST00000394450ENST00000274473PRELID2chr5

145144494

-MEGF10chr5

126769055

+
3UTR-intronENST00000394450ENST00000510828PRELID2chr5

145144494

-MEGF10chr5

126769055

+
3UTR-3CDSENST00000505416ENST00000503335PRELID2chr5

145144494

-MEGF10chr5

126769055

+
3UTR-intronENST00000505416ENST00000508365PRELID2chr5

145144494

-MEGF10chr5

126769055

+
3UTR-intronENST00000505416ENST00000418761PRELID2chr5

145144494

-MEGF10chr5

126769055

+
3UTR-intronENST00000505416ENST00000274473PRELID2chr5

145144494

-MEGF10chr5

126769055

+
3UTR-intronENST00000505416ENST00000510828PRELID2chr5

145144494

-MEGF10chr5

126769055

+
intron-3CDSENST00000511435ENST00000503335PRELID2chr5

145144494

-MEGF10chr5

126769055

+
intron-intronENST00000511435ENST00000508365PRELID2chr5

145144494

-MEGF10chr5

126769055

+
intron-intronENST00000511435ENST00000418761PRELID2chr5

145144494

-MEGF10chr5

126769055

+
intron-intronENST00000511435ENST00000274473PRELID2chr5

145144494

-MEGF10chr5

126769055

+
intron-intronENST00000511435ENST00000510828PRELID2chr5

145144494

-MEGF10chr5

126769055

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for PRELID2-MEGF10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PRELID2chr5145144493-MEGF10chr5126769054+0.0001806350.99981934
PRELID2chr5145144493-MEGF10chr5126769054+0.0001806350.99981934

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PRELID2-MEGF10


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MEGF10

Q96KG7

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells (PubMed:27170117). Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides (PubMed:20828568, PubMed:17643423). Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum (PubMed:27170117). Plays role in muscle cell proliferation, adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway (PubMed:28498977, Ref.14). May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (PubMed:17498693, PubMed:17643423, PubMed:20828568, PubMed:22101682, PubMed:27170117, PubMed:28498977). {ECO:0000269|PubMed:17205124, ECO:0000269|PubMed:17498693, ECO:0000269|PubMed:17643423, ECO:0000269|PubMed:20828568, ECO:0000269|PubMed:22101682, ECO:0000269|PubMed:27170117, ECO:0000269|PubMed:28498977, ECO:0000269|Ref.14}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for PRELID2-MEGF10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PRELID2-MEGF10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PRELID2-MEGF10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PRELID2-MEGF10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMEGF10C3280679MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET8CLINGEN;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneMEGF10C3541476MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET, MILD VARIANT2ORPHANET
TgeneMEGF10C0011168Deglutition Disorders1CTD_human
TgeneMEGF10C0026848Myopathy1CTD_human
TgeneMEGF10C0035220Respiratory Distress Syndrome, Newborn1CTD_human
TgeneMEGF10C0036341Schizophrenia1PSYGENET
TgeneMEGF10C0267071Oropharyngeal Dysphagia1CTD_human
TgeneMEGF10C0267072Esophageal Dysphagia1CTD_human