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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PRKAG2-ACTR3C (FusionGDB2 ID:68204)

Fusion Gene Summary for PRKAG2-ACTR3C

Fusion gene summary

Fusion gene information	Fusion gene name: PRKAG2-ACTR3C
	Fusion gene ID: 68204
		Hgene	Tgene
	Gene symbol	PRKAG2	ACTR3C
	Gene ID	51422	653857
	Gene name	protein kinase AMP-activated non-catalytic subunit gamma 2	actin related protein 3C
	Synonyms	AAKG\|AAKG2\|CMH6\|H91620p\|WPWS	ARP11
	Cytomap	7q36.1	7q36.1
	Type of gene	protein-coding	protein-coding
	Description	5'-AMP-activated protein kinase subunit gamma-2AMPK subunit gamma-2epididymis secretory sperm binding proteinprotein kinase, AMP-activated, gamma 2 non-catalytic subunit	actin-related protein 3CARP3 actin related protein 3 homolog Cactin-related Arp11actin-related protein 11
	Modification date	20200320	20200313
	UniProtAcc	.	Q9C0K3
	Ensembl transtripts involved in fusion gene	ENST00000287878, ENST00000418337, ENST00000433631, ENST00000492843, ENST00000392801, ENST00000461529,	ENST00000252071, ENST00000539352,
Fusion gene scores	* DoF score	16 X 11 X 10=1760	6 X 5 X 3=90
	# samples	21	6
	** MAII score	log2(21/1760*10)=-3.06711419585854 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PRKAG2 [Title/Abstract] AND ACTR3C [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PRKAG2(151372506)-ACTR3C(149946143), # samples:2
Anticipated loss of major functional domain due to fusion event.	PRKAG2-ACTR3C seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. PRKAG2-ACTR3C seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PRKAG2-ACTR3C seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PRKAG2-ACTR3C seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PRKAG2	GO:0006469	negative regulation of protein kinase activity	17255938

Fusion gene breakpoints across PRKAG2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ACTR3C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-2Y-A9HA-01A	PRKAG2	chr7	151372506	-	ACTR3C	chr7	149946143	-
ChimerDB4	LIHC	TCGA-2Y-A9HA-01A	PRKAG2	chr7	151372506	-	ACTR3C	chr7	149946143	-

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Fusion Gene ORF analysis for PRKAG2-ACTR3C

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000287878	ENST00000252071	PRKAG2	chr7	151372506	-	ACTR3C	chr7	149946143	-
In-frame	ENST00000287878	ENST00000539352	PRKAG2	chr7	151372506	-	ACTR3C	chr7	149946143	-
intron-3CDS	ENST00000418337	ENST00000252071	PRKAG2	chr7	151372506	-	ACTR3C	chr7	149946143	-
intron-3CDS	ENST00000418337	ENST00000539352	PRKAG2	chr7	151372506	-	ACTR3C	chr7	149946143	-
In-frame	ENST00000433631	ENST00000252071	PRKAG2	chr7	151372506	-	ACTR3C	chr7	149946143	-
In-frame	ENST00000433631	ENST00000539352	PRKAG2	chr7	151372506	-	ACTR3C	chr7	149946143	-
In-frame	ENST00000492843	ENST00000252071	PRKAG2	chr7	151372506	-	ACTR3C	chr7	149946143	-
In-frame	ENST00000492843	ENST00000539352	PRKAG2	chr7	151372506	-	ACTR3C	chr7	149946143	-
Frame-shift	ENST00000392801	ENST00000252071	PRKAG2	chr7	151372506	-	ACTR3C	chr7	149946143	-
Frame-shift	ENST00000392801	ENST00000539352	PRKAG2	chr7	151372506	-	ACTR3C	chr7	149946143	-
intron-3CDS	ENST00000461529	ENST00000252071	PRKAG2	chr7	151372506	-	ACTR3C	chr7	149946143	-
intron-3CDS	ENST00000461529	ENST00000539352	PRKAG2	chr7	151372506	-	ACTR3C	chr7	149946143	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000287878	PRKAG2	chr7	151372506	-	ENST00000252071	ACTR3C	chr7	149946143	-	1653	1189	493	1257	254
ENST00000287878	PRKAG2	chr7	151372506	-	ENST00000539352	ACTR3C	chr7	149946143	-	1653	1189	493	1257	254
ENST00000433631	PRKAG2	chr7	151372506	-	ENST00000252071	ACTR3C	chr7	149946143	-	1046	582	750	289	153
ENST00000433631	PRKAG2	chr7	151372506	-	ENST00000539352	ACTR3C	chr7	149946143	-	1046	582	750	289	153
ENST00000492843	PRKAG2	chr7	151372506	-	ENST00000252071	ACTR3C	chr7	149946143	-	1097	633	801	340	153
ENST00000492843	PRKAG2	chr7	151372506	-	ENST00000539352	ACTR3C	chr7	149946143	-	1097	633	801	340	153

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000287878	ENST00000252071	PRKAG2	chr7	151372506	-	ACTR3C	chr7	149946143	-	0.33794877	0.6620512
ENST00000287878	ENST00000539352	PRKAG2	chr7	151372506	-	ACTR3C	chr7	149946143	-	0.33794877	0.6620512
ENST00000433631	ENST00000252071	PRKAG2	chr7	151372506	-	ACTR3C	chr7	149946143	-	0.45865238	0.5413476
ENST00000433631	ENST00000539352	PRKAG2	chr7	151372506	-	ACTR3C	chr7	149946143	-	0.45865238	0.5413476
ENST00000492843	ENST00000252071	PRKAG2	chr7	151372506	-	ACTR3C	chr7	149946143	-	0.55577713	0.4442228
ENST00000492843	ENST00000539352	PRKAG2	chr7	151372506	-	ACTR3C	chr7	149946143	-	0.55577713	0.4442228

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Fusion Genomic Features for PRKAG2-ACTR3C

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PRKAG2-ACTR3C

Go to
FGviewer for the breakpoints of chr7:151372506-chr7:149946143
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ACTR3C Q9C0K3
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells. {ECO:0000269\|PubMed:11162478}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000287878

275_335

228.0

570.0

Domain

CBS 1

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000287878

357_415

228.0

570.0

Domain

CBS 2

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000287878

430_492

228.0

570.0

Domain

CBS 3

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000287878

504_562

228.0

570.0

Domain

CBS 4

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000392801

275_335

184.0

526.0

Domain

CBS 1

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000392801

357_415

184.0

526.0

Domain

CBS 2

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000392801

430_492

184.0

526.0

Domain

CBS 3

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000392801

504_562

184.0

526.0

Domain

CBS 4

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000418337

275_335

329.0

Domain

CBS 1

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000418337

357_415

329.0

Domain

CBS 2

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000418337

430_492

329.0

Domain

CBS 3

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000418337

504_562

329.0

Domain

CBS 4

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000287878

370_391

228.0

570.0

Motif

Note=AMPK pseudosubstrate

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000392801

370_391

184.0

526.0

Motif

Note=AMPK pseudosubstrate

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000418337

370_391

329.0

Motif

Note=AMPK pseudosubstrate

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000287878

319_322

228.0

570.0

Nucleotide binding

AMP%2C ADP or ATP 1

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000287878

383_384

228.0

570.0

Nucleotide binding

AMP%2C ADP or ATP 1

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000287878

458_459

228.0

570.0

Nucleotide binding

AMP 3

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000287878

474_477

228.0

570.0

Nucleotide binding

AMP%2C ADP or ATP 2

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000287878

530_531

228.0

570.0

Nucleotide binding

AMP%2C ADP or ATP 2

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000287878

546_549

228.0

570.0

Nucleotide binding

AMP 3

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000392801

319_322

184.0

526.0

Nucleotide binding

AMP%2C ADP or ATP 1

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000392801

383_384

184.0

526.0

Nucleotide binding

AMP%2C ADP or ATP 1

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000392801

458_459

184.0

526.0

Nucleotide binding

AMP 3

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000392801

474_477

184.0

526.0

Nucleotide binding

AMP%2C ADP or ATP 2

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000392801

530_531

184.0

526.0

Nucleotide binding

AMP%2C ADP or ATP 2

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000392801

546_549

184.0

526.0

Nucleotide binding

AMP 3

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000418337

319_322

329.0

Nucleotide binding

AMP%2C ADP or ATP 1

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000418337

383_384

329.0

Nucleotide binding

AMP%2C ADP or ATP 1

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000418337

458_459

329.0

Nucleotide binding

AMP 3

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000418337

474_477

329.0

Nucleotide binding

AMP%2C ADP or ATP 2

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000418337

530_531

329.0

Nucleotide binding

AMP%2C ADP or ATP 2

Hgene

PRKAG2

chr7:151372506

chr7:149946143

ENST00000418337

546_549

329.0

Nucleotide binding

AMP 3

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Fusion Gene Sequence for PRKAG2-ACTR3C

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000287878_ENST00000252071_TCGA-2Y-A9HA-01A_PRKAG2_chr7_151372506_-_ACTR3C_chr7_149946143_length(transcript)=1653nt_BP=1189nt
GAGCTGGTTTATTCTGCGGCCGAGGATTACATTTATGCACGAACGGGCTTACTGGTTCCAGATTCCCCACTTGGGCACAGGCATAGGAGG
CTTGTTTTCCAAATTGCTGGTTTTAATTGCACCTGCCTTTCAGATTACCTCTGGGAATCTGTGGGAGGAGCCGAGAGGGTGGAAAATGTT
TCTTAGCTTTGCAAAAGGAAGAAAACTTTGTCACCCAGCGGGAGACCTCAGCCACGAGTAACCCGGGGAGACACCAGAACCGGGACGGGC
TTTGACTGATTTGCCTACGAGGGTTCCGTAGGAAAGGACGCTTGAATTCGGCGCTTCGGCGGCGGCGGCGGCCGCGCGAGTTCCCTGCTC
ACCCTCCCTCTCCGCGGAAGTCCCCACGAGGTGGCTTCAGGGTGTAACAGAGCGCGCGGCTCCAGTCCGAAGGCAGCGGCCGGGGGAGGG
AAGGAGGGGACCGAACCCCCGAGGAGTTTCGCAGAATCAACTTCTGGTTAGAGTTATGGGAAGCGCGGTTATGGACACCAAGAAGAAAAA
AGATGTTTCCAGCCCCGGCGGGAGCGGCGGCAAGAAAAATGCCAGCCAGAAGAGGCGTTCGCTGCGCGTGCACATTCCGGACCTGAGCTC
CTTCGCCATGCCGCTCCTGGACGGAGACCTGGAGGGTTCCGGAAAGCATTCCTCTCGAAAGGTGGACAGCCCCTTCGGCCCGGGCAGCCC
CTCCAAAGGGTTCTTCTCCAGAGGCCCCCAGCCCCGGCCCTCCAGCCCCATGTCTGCACCTGTGAGGCCCAAGACCAGCCCCGGCTCTCC
CAAAACCGTGTTCCCGTTCTCCTACCAGGAGTCCCCGCCACGCTCCCCTCGACGCATGAGCTTCAGTGGGATCTTCCGCTCCTCCTCCAA
AGAGTCTTCCCCCAACTCCAACCCTGCTACCTCGCCCGGGGGCATCAGGTTTTTCTCCCGCTCCAGAAAAACCTCCGGCCTCTCCTCCTC
TCCGTCAACACCCACCCAAGTGACCAAGCAGCACACGTTTCCCCTGGAATCCTATAAGCACGAGCCTGAACGGTTAGAGAATCGCATCTA
TGCCTCGTCTTCCCCCCCGGACACAGGGCAGAGGTTCTGCCCGTCTTCCTTCCAGAGCCCGACCAGGCCTCCACTGGCATCACCGACACA
CTATGCTCCCTCCAAAGCCATGGAACAAATTCCACTGAGCTATCCTCAAGGTCACGGATTCCATCCTCTGTCACCTCCATTTCATTGAGA
TGATATATTGAGCCCATGCGTAGCCTTTTATTTGAGATTTCCAAGGCCAGCAATGTTCTCTTCCTCTCCCTTTTCTTTGTATAAAAATTC
ATTCTCAAGAAAAACTCTCATATCAATTGTTTACATGTCACTATGGCTAAGACACTAAAAGCCCTCTCCCTGCAAAACTGGTGGCAAAGC
TCTCTAGAGAACCACAAACTGTTGCATCCTTACTACGTGGGGCAGCAGCAAGCCCAGGTGAAGATGTGCATGTTCTTGGAGAAAGTATTA
ATAACATACCGACACTTACATCTGGGTGAATAATTTCATCAAATCTCTTAACTCACGCTTGCACAAACTTCACCTGGAGAGAGAGAGGGA

>In-frame_ENST00000287878_ENST00000252071_TCGA-2Y-A9HA-01A_PRKAG2_chr7_151372506_-_ACTR3C_chr7_149946143_length(amino acids)=254AA_start in transcript=493_stop in transcript=1257
MVRVMGSAVMDTKKKKDVSSPGGSGGKKNASQKRRSLRVHIPDLSSFAMPLLDGDLEGSGKHSSRKVDSPFGPGSPSKGFFSRGPQPRPS
SPMSAPVRPKTSPGSPKTVFPFSYQESPPRSPRRMSFSGIFRSSSKESSPNSNPATSPGGIRFFSRSRKTSGLSSSPSTPTQVTKQHTFP

--------------------------------------------------------------
>In-frame_ENST00000287878_ENST00000539352_TCGA-2Y-A9HA-01A_PRKAG2_chr7_151372506_-_ACTR3C_chr7_149946143_length(transcript)=1653nt_BP=1189nt
GAGCTGGTTTATTCTGCGGCCGAGGATTACATTTATGCACGAACGGGCTTACTGGTTCCAGATTCCCCACTTGGGCACAGGCATAGGAGG
CTTGTTTTCCAAATTGCTGGTTTTAATTGCACCTGCCTTTCAGATTACCTCTGGGAATCTGTGGGAGGAGCCGAGAGGGTGGAAAATGTT
TCTTAGCTTTGCAAAAGGAAGAAAACTTTGTCACCCAGCGGGAGACCTCAGCCACGAGTAACCCGGGGAGACACCAGAACCGGGACGGGC
TTTGACTGATTTGCCTACGAGGGTTCCGTAGGAAAGGACGCTTGAATTCGGCGCTTCGGCGGCGGCGGCGGCCGCGCGAGTTCCCTGCTC
ACCCTCCCTCTCCGCGGAAGTCCCCACGAGGTGGCTTCAGGGTGTAACAGAGCGCGCGGCTCCAGTCCGAAGGCAGCGGCCGGGGGAGGG
AAGGAGGGGACCGAACCCCCGAGGAGTTTCGCAGAATCAACTTCTGGTTAGAGTTATGGGAAGCGCGGTTATGGACACCAAGAAGAAAAA
AGATGTTTCCAGCCCCGGCGGGAGCGGCGGCAAGAAAAATGCCAGCCAGAAGAGGCGTTCGCTGCGCGTGCACATTCCGGACCTGAGCTC
CTTCGCCATGCCGCTCCTGGACGGAGACCTGGAGGGTTCCGGAAAGCATTCCTCTCGAAAGGTGGACAGCCCCTTCGGCCCGGGCAGCCC
CTCCAAAGGGTTCTTCTCCAGAGGCCCCCAGCCCCGGCCCTCCAGCCCCATGTCTGCACCTGTGAGGCCCAAGACCAGCCCCGGCTCTCC
CAAAACCGTGTTCCCGTTCTCCTACCAGGAGTCCCCGCCACGCTCCCCTCGACGCATGAGCTTCAGTGGGATCTTCCGCTCCTCCTCCAA
AGAGTCTTCCCCCAACTCCAACCCTGCTACCTCGCCCGGGGGCATCAGGTTTTTCTCCCGCTCCAGAAAAACCTCCGGCCTCTCCTCCTC
TCCGTCAACACCCACCCAAGTGACCAAGCAGCACACGTTTCCCCTGGAATCCTATAAGCACGAGCCTGAACGGTTAGAGAATCGCATCTA
TGCCTCGTCTTCCCCCCCGGACACAGGGCAGAGGTTCTGCCCGTCTTCCTTCCAGAGCCCGACCAGGCCTCCACTGGCATCACCGACACA
CTATGCTCCCTCCAAAGCCATGGAACAAATTCCACTGAGCTATCCTCAAGGTCACGGATTCCATCCTCTGTCACCTCCATTTCATTGAGA
TGATATATTGAGCCCATGCGTAGCCTTTTATTTGAGATTTCCAAGGCCAGCAATGTTCTCTTCCTCTCCCTTTTCTTTGTATAAAAATTC
ATTCTCAAGAAAAACTCTCATATCAATTGTTTACATGTCACTATGGCTAAGACACTAAAAGCCCTCTCCCTGCAAAACTGGTGGCAAAGC
TCTCTAGAGAACCACAAACTGTTGCATCCTTACTACGTGGGGCAGCAGCAAGCCCAGGTGAAGATGTGCATGTTCTTGGAGAAAGTATTA
ATAACATACCGACACTTACATCTGGGTGAATAATTTCATCAAATCTCTTAACTCACGCTTGCACAAACTTCACCTGGAGAGAGAGAGGGA

>In-frame_ENST00000287878_ENST00000539352_TCGA-2Y-A9HA-01A_PRKAG2_chr7_151372506_-_ACTR3C_chr7_149946143_length(amino acids)=254AA_start in transcript=493_stop in transcript=1257
MVRVMGSAVMDTKKKKDVSSPGGSGGKKNASQKRRSLRVHIPDLSSFAMPLLDGDLEGSGKHSSRKVDSPFGPGSPSKGFFSRGPQPRPS
SPMSAPVRPKTSPGSPKTVFPFSYQESPPRSPRRMSFSGIFRSSSKESSPNSNPATSPGGIRFFSRSRKTSGLSSSPSTPTQVTKQHTFP

--------------------------------------------------------------
>In-frame_ENST00000433631_ENST00000252071_TCGA-2Y-A9HA-01A_PRKAG2_chr7_151372506_-_ACTR3C_chr7_149946143_length(transcript)=1046nt_BP=582nt
GCTGTGGCCGGAGGTGCAGCCCCGTCAGGACGGCTCCACTCCCTGGCGCCTCACAGACTCTGGGGCTGCGGTGAGGTCGCCCTGAAGACC
CCCTGGTGAGGACGCTTGAACCCGGGCTGTCACCTGAGCACAGGCTGCCACTCTGAGCTTTTGGGGCGCCCTGTGCCTGTCGGGCTGATG
CTCCTCTGGCTCCCGGCCACCTGGGGCTGACACCGGTTCTGTGGGTCCTGATATGTTCACCTGTCGCCACTCCTGTGGCCACAGCTACCC
ATGAAGCGCTTTGGGAGCCTCAGGAGCAACAAGAAACACAAGGACCAAAATCGAAGCACGGAGAGGCGCCAGTCGGAGCCTCATGGCCTT
TTCGCCTCCGGCCTCTCCTCCTCTCCGTCAACACCCACCCAAGTGACCAAGCAGCACACGTTTCCCCTGGAATCCTATAAGCACGAGCCT
GAACGGTTAGAGAATCGCATCTATGCCTCGTCTTCCCCCCCGGACACAGGGCAGAGGTTCTGCCCGTCTTCCTTCCAGAGCCCGACCAGG
CCTCCACTGGCATCACCGACACACTATGCTCCCTCCAAAGCCATGGAACAAATTCCACTGAGCTATCCTCAAGGTCACGGATTCCATCCT
CTGTCACCTCCATTTCATTGAGATGATATATTGAGCCCATGCGTAGCCTTTTATTTGAGATTTCCAAGGCCAGCAATGTTCTCTTCCTCT
CCCTTTTCTTTGTATAAAAATTCATTCTCAAGAAAAACTCTCATATCAATTGTTTACATGTCACTATGGCTAAGACACTAAAAGCCCTCT
CCCTGCAAAACTGGTGGCAAAGCTCTCTAGAGAACCACAAACTGTTGCATCCTTACTACGTGGGGCAGCAGCAAGCCCAGGTGAAGATGT
GCATGTTCTTGGAGAAAGTATTAATAACATACCGACACTTACATCTGGGTGAATAATTTCATCAAATCTCTTAACTCACGCTTGCACAAA

>In-frame_ENST00000433631_ENST00000252071_TCGA-2Y-A9HA-01A_PRKAG2_chr7_151372506_-_ACTR3C_chr7_149946143_length(amino acids)=153AA_start in transcript=750_stop in transcript=289
MRMNFYTKKRERKRTLLALEISNKRLRMGSIYHLNEMEVTEDGIRDLEDSSVEFVPWLWREHSVSVMPVEAWSGSGRKTGRTSALCPGGK

--------------------------------------------------------------
>In-frame_ENST00000433631_ENST00000539352_TCGA-2Y-A9HA-01A_PRKAG2_chr7_151372506_-_ACTR3C_chr7_149946143_length(transcript)=1046nt_BP=582nt
GCTGTGGCCGGAGGTGCAGCCCCGTCAGGACGGCTCCACTCCCTGGCGCCTCACAGACTCTGGGGCTGCGGTGAGGTCGCCCTGAAGACC
CCCTGGTGAGGACGCTTGAACCCGGGCTGTCACCTGAGCACAGGCTGCCACTCTGAGCTTTTGGGGCGCCCTGTGCCTGTCGGGCTGATG
CTCCTCTGGCTCCCGGCCACCTGGGGCTGACACCGGTTCTGTGGGTCCTGATATGTTCACCTGTCGCCACTCCTGTGGCCACAGCTACCC
ATGAAGCGCTTTGGGAGCCTCAGGAGCAACAAGAAACACAAGGACCAAAATCGAAGCACGGAGAGGCGCCAGTCGGAGCCTCATGGCCTT
TTCGCCTCCGGCCTCTCCTCCTCTCCGTCAACACCCACCCAAGTGACCAAGCAGCACACGTTTCCCCTGGAATCCTATAAGCACGAGCCT
GAACGGTTAGAGAATCGCATCTATGCCTCGTCTTCCCCCCCGGACACAGGGCAGAGGTTCTGCCCGTCTTCCTTCCAGAGCCCGACCAGG
CCTCCACTGGCATCACCGACACACTATGCTCCCTCCAAAGCCATGGAACAAATTCCACTGAGCTATCCTCAAGGTCACGGATTCCATCCT
CTGTCACCTCCATTTCATTGAGATGATATATTGAGCCCATGCGTAGCCTTTTATTTGAGATTTCCAAGGCCAGCAATGTTCTCTTCCTCT
CCCTTTTCTTTGTATAAAAATTCATTCTCAAGAAAAACTCTCATATCAATTGTTTACATGTCACTATGGCTAAGACACTAAAAGCCCTCT
CCCTGCAAAACTGGTGGCAAAGCTCTCTAGAGAACCACAAACTGTTGCATCCTTACTACGTGGGGCAGCAGCAAGCCCAGGTGAAGATGT
GCATGTTCTTGGAGAAAGTATTAATAACATACCGACACTTACATCTGGGTGAATAATTTCATCAAATCTCTTAACTCACGCTTGCACAAA

>In-frame_ENST00000433631_ENST00000539352_TCGA-2Y-A9HA-01A_PRKAG2_chr7_151372506_-_ACTR3C_chr7_149946143_length(amino acids)=153AA_start in transcript=750_stop in transcript=289
MRMNFYTKKRERKRTLLALEISNKRLRMGSIYHLNEMEVTEDGIRDLEDSSVEFVPWLWREHSVSVMPVEAWSGSGRKTGRTSALCPGGK

--------------------------------------------------------------
>In-frame_ENST00000492843_ENST00000252071_TCGA-2Y-A9HA-01A_PRKAG2_chr7_151372506_-_ACTR3C_chr7_149946143_length(transcript)=1097nt_BP=633nt
GCTTCCGGCAGCTTCTTGCTACTTAAGGACAGCCGGGCTGACGCTCCAGCTGCTGTGGCCGGAGGTGCAGCCCCGTCAGGACGGCTCCAC
TCCCTGGCGCCTCACAGACTCTGGGGCTGCGGTGAGGTCGCCCTGAAGACCCCCTGGTGAGGACGCTTGAACCCGGGCTGTCACCTGAGC
ACAGGCTGCCACTCTGAGCTTTTGGGGCGCCCTGTGCCTGTCGGGCTGATGCTCCTCTGGCTCCCGGCCACCTGGGGCTGACACCGGTTC
TGTGGGTCCTGATATGTTCACCTGTCGCCACTCCTGTGGCCACAGCTACCCATGAAGCGCTTTGGGAGCCTCAGGAGCAACAAGAAACAC
AAGGACCAAAATCGAAGCACGGAGAGGCGCCAGTCGGAGCCTCATGGCCTTTTCGCCTCCGGCCTCTCCTCCTCTCCGTCAACACCCACC
CAAGTGACCAAGCAGCACACGTTTCCCCTGGAATCCTATAAGCACGAGCCTGAACGGTTAGAGAATCGCATCTATGCCTCGTCTTCCCCC
CCGGACACAGGGCAGAGGTTCTGCCCGTCTTCCTTCCAGAGCCCGACCAGGCCTCCACTGGCATCACCGACACACTATGCTCCCTCCAAA
GCCATGGAACAAATTCCACTGAGCTATCCTCAAGGTCACGGATTCCATCCTCTGTCACCTCCATTTCATTGAGATGATATATTGAGCCCA
TGCGTAGCCTTTTATTTGAGATTTCCAAGGCCAGCAATGTTCTCTTCCTCTCCCTTTTCTTTGTATAAAAATTCATTCTCAAGAAAAACT
CTCATATCAATTGTTTACATGTCACTATGGCTAAGACACTAAAAGCCCTCTCCCTGCAAAACTGGTGGCAAAGCTCTCTAGAGAACCACA
AACTGTTGCATCCTTACTACGTGGGGCAGCAGCAAGCCCAGGTGAAGATGTGCATGTTCTTGGAGAAAGTATTAATAACATACCGACACT
TACATCTGGGTGAATAATTTCATCAAATCTCTTAACTCACGCTTGCACAAACTTCACCTGGAGAGAGAGAGGGAAAGCTGTGCCAGAAAT

>In-frame_ENST00000492843_ENST00000252071_TCGA-2Y-A9HA-01A_PRKAG2_chr7_151372506_-_ACTR3C_chr7_149946143_length(amino acids)=153AA_start in transcript=801_stop in transcript=340
MRMNFYTKKRERKRTLLALEISNKRLRMGSIYHLNEMEVTEDGIRDLEDSSVEFVPWLWREHSVSVMPVEAWSGSGRKTGRTSALCPGGK

--------------------------------------------------------------
>In-frame_ENST00000492843_ENST00000539352_TCGA-2Y-A9HA-01A_PRKAG2_chr7_151372506_-_ACTR3C_chr7_149946143_length(transcript)=1097nt_BP=633nt
GCTTCCGGCAGCTTCTTGCTACTTAAGGACAGCCGGGCTGACGCTCCAGCTGCTGTGGCCGGAGGTGCAGCCCCGTCAGGACGGCTCCAC
TCCCTGGCGCCTCACAGACTCTGGGGCTGCGGTGAGGTCGCCCTGAAGACCCCCTGGTGAGGACGCTTGAACCCGGGCTGTCACCTGAGC
ACAGGCTGCCACTCTGAGCTTTTGGGGCGCCCTGTGCCTGTCGGGCTGATGCTCCTCTGGCTCCCGGCCACCTGGGGCTGACACCGGTTC
TGTGGGTCCTGATATGTTCACCTGTCGCCACTCCTGTGGCCACAGCTACCCATGAAGCGCTTTGGGAGCCTCAGGAGCAACAAGAAACAC
AAGGACCAAAATCGAAGCACGGAGAGGCGCCAGTCGGAGCCTCATGGCCTTTTCGCCTCCGGCCTCTCCTCCTCTCCGTCAACACCCACC
CAAGTGACCAAGCAGCACACGTTTCCCCTGGAATCCTATAAGCACGAGCCTGAACGGTTAGAGAATCGCATCTATGCCTCGTCTTCCCCC
CCGGACACAGGGCAGAGGTTCTGCCCGTCTTCCTTCCAGAGCCCGACCAGGCCTCCACTGGCATCACCGACACACTATGCTCCCTCCAAA
GCCATGGAACAAATTCCACTGAGCTATCCTCAAGGTCACGGATTCCATCCTCTGTCACCTCCATTTCATTGAGATGATATATTGAGCCCA
TGCGTAGCCTTTTATTTGAGATTTCCAAGGCCAGCAATGTTCTCTTCCTCTCCCTTTTCTTTGTATAAAAATTCATTCTCAAGAAAAACT
CTCATATCAATTGTTTACATGTCACTATGGCTAAGACACTAAAAGCCCTCTCCCTGCAAAACTGGTGGCAAAGCTCTCTAGAGAACCACA
AACTGTTGCATCCTTACTACGTGGGGCAGCAGCAAGCCCAGGTGAAGATGTGCATGTTCTTGGAGAAAGTATTAATAACATACCGACACT
TACATCTGGGTGAATAATTTCATCAAATCTCTTAACTCACGCTTGCACAAACTTCACCTGGAGAGAGAGAGGGAAAGCTGTGCCAGAAAT

>In-frame_ENST00000492843_ENST00000539352_TCGA-2Y-A9HA-01A_PRKAG2_chr7_151372506_-_ACTR3C_chr7_149946143_length(amino acids)=153AA_start in transcript=801_stop in transcript=340
MRMNFYTKKRERKRTLLALEISNKRLRMGSIYHLNEMEVTEDGIRDLEDSSVEFVPWLWREHSVSVMPVEAWSGSGRKTGRTSALCPGGK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PRKAG2-ACTR3C

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PRKAG2-ACTR3C

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PRKAG2-ACTR3C

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	PRKAG2	C0007194	Hypertrophic Cardiomyopathy	15	CLINGEN
Hgene	PRKAG2	C0043202	Wolff-Parkinson-White Syndrome	6	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	PRKAG2	C1833236	CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 6 (disorder)	5	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	PRKAG2	C1849813	Glycogen Storage Disease of Heart, Lethal Congenital	5	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT