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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PRKAG2-RHEB (FusionGDB2 ID:68219)

Fusion Gene Summary for PRKAG2-RHEB

check button Fusion gene summary
Fusion gene informationFusion gene name: PRKAG2-RHEB
Fusion gene ID: 68219
HgeneTgene
Gene symbol

PRKAG2

RHEB

Gene ID

51422

6009

Gene nameprotein kinase AMP-activated non-catalytic subunit gamma 2Ras homolog, mTORC1 binding
SynonymsAAKG|AAKG2|CMH6|H91620p|WPWSRHEB2
Cytomap

7q36.1

7q36.1

Type of geneprotein-codingprotein-coding
Description5'-AMP-activated protein kinase subunit gamma-2AMPK subunit gamma-2epididymis secretory sperm binding proteinprotein kinase, AMP-activated, gamma 2 non-catalytic subunitGTP-binding protein RhebRas homolog enriched in brain 2
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000287878, ENST00000418337, 
ENST00000433631, ENST00000492843, 
ENST00000392801, ENST00000461529, 
ENST00000262187, ENST00000472642, 
ENST00000496004, 
Fusion gene scores* DoF score16 X 11 X 10=176010 X 5 X 8=400
# samples 2112
** MAII scorelog2(21/1760*10)=-3.06711419585854
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/400*10)=-1.73696559416621
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRKAG2 [Title/Abstract] AND RHEB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPRKAG2(151292431)-RHEB(151188100), # samples:1
PRKAG2(151478238)-RHEB(151188100), # samples:1
PRKAG2(151329155)-RHEB(151188100), # samples:1
RHEB(151216545)-PRKAG2(151329224), # samples:1
RHEB(151216546)-PRKAG2(151372723), # samples:1
RHEB(151216546)-PRKAG2(151257703), # samples:1
Anticipated loss of major functional domain due to fusion event.PRKAG2-RHEB seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PRKAG2-RHEB seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PRKAG2-RHEB seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PRKAG2-RHEB seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
PRKAG2-RHEB seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
RHEB-PRKAG2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RHEB-PRKAG2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
RHEB-PRKAG2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
RHEB-PRKAG2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
RHEB-PRKAG2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRKAG2

GO:0006469

negative regulation of protein kinase activity

17255938


check buttonFusion gene breakpoints across PRKAG2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RHEB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A2LR-01APRKAG2chr7

151292431

-RHEBchr7

151188100

-
ChimerDB4LIHCTCGA-DD-A1ED-01APRKAG2chr7

151478238

-RHEBchr7

151188100

-
ChimerDB4STADTCGA-BR-8059-01APRKAG2chr7

151329155

-RHEBchr7

151188100

-


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Fusion Gene ORF analysis for PRKAG2-RHEB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000287878ENST00000262187PRKAG2chr7

151292431

-RHEBchr7

151188100

-
5CDS-5UTRENST00000287878ENST00000472642PRKAG2chr7

151292431

-RHEBchr7

151188100

-
5CDS-5UTRENST00000287878ENST00000496004PRKAG2chr7

151292431

-RHEBchr7

151188100

-
Frame-shiftENST00000418337ENST00000262187PRKAG2chr7

151292431

-RHEBchr7

151188100

-
5CDS-5UTRENST00000418337ENST00000472642PRKAG2chr7

151292431

-RHEBchr7

151188100

-
5CDS-5UTRENST00000418337ENST00000496004PRKAG2chr7

151292431

-RHEBchr7

151188100

-
Frame-shiftENST00000433631ENST00000262187PRKAG2chr7

151292431

-RHEBchr7

151188100

-
5CDS-5UTRENST00000433631ENST00000472642PRKAG2chr7

151292431

-RHEBchr7

151188100

-
5CDS-5UTRENST00000433631ENST00000496004PRKAG2chr7

151292431

-RHEBchr7

151188100

-
Frame-shiftENST00000492843ENST00000262187PRKAG2chr7

151292431

-RHEBchr7

151188100

-
5CDS-5UTRENST00000492843ENST00000472642PRKAG2chr7

151292431

-RHEBchr7

151188100

-
5CDS-5UTRENST00000492843ENST00000496004PRKAG2chr7

151292431

-RHEBchr7

151188100

-
Frame-shiftENST00000392801ENST00000262187PRKAG2chr7

151292431

-RHEBchr7

151188100

-
5CDS-5UTRENST00000392801ENST00000472642PRKAG2chr7

151292431

-RHEBchr7

151188100

-
5CDS-5UTRENST00000392801ENST00000496004PRKAG2chr7

151292431

-RHEBchr7

151188100

-
intron-3CDSENST00000461529ENST00000262187PRKAG2chr7

151292431

-RHEBchr7

151188100

-
intron-5UTRENST00000461529ENST00000472642PRKAG2chr7

151292431

-RHEBchr7

151188100

-
intron-5UTRENST00000461529ENST00000496004PRKAG2chr7

151292431

-RHEBchr7

151188100

-
In-frameENST00000287878ENST00000262187PRKAG2chr7

151478238

-RHEBchr7

151188100

-
5CDS-5UTRENST00000287878ENST00000472642PRKAG2chr7

151478238

-RHEBchr7

151188100

-
5CDS-5UTRENST00000287878ENST00000496004PRKAG2chr7

151478238

-RHEBchr7

151188100

-
intron-3CDSENST00000418337ENST00000262187PRKAG2chr7

151478238

-RHEBchr7

151188100

-
intron-5UTRENST00000418337ENST00000472642PRKAG2chr7

151478238

-RHEBchr7

151188100

-
intron-5UTRENST00000418337ENST00000496004PRKAG2chr7

151478238

-RHEBchr7

151188100

-
intron-3CDSENST00000433631ENST00000262187PRKAG2chr7

151478238

-RHEBchr7

151188100

-
intron-5UTRENST00000433631ENST00000472642PRKAG2chr7

151478238

-RHEBchr7

151188100

-
intron-5UTRENST00000433631ENST00000496004PRKAG2chr7

151478238

-RHEBchr7

151188100

-
intron-3CDSENST00000492843ENST00000262187PRKAG2chr7

151478238

-RHEBchr7

151188100

-
intron-5UTRENST00000492843ENST00000472642PRKAG2chr7

151478238

-RHEBchr7

151188100

-
intron-5UTRENST00000492843ENST00000496004PRKAG2chr7

151478238

-RHEBchr7

151188100

-
Frame-shiftENST00000392801ENST00000262187PRKAG2chr7

151478238

-RHEBchr7

151188100

-
5CDS-5UTRENST00000392801ENST00000472642PRKAG2chr7

151478238

-RHEBchr7

151188100

-
5CDS-5UTRENST00000392801ENST00000496004PRKAG2chr7

151478238

-RHEBchr7

151188100

-
5UTR-3CDSENST00000461529ENST00000262187PRKAG2chr7

151478238

-RHEBchr7

151188100

-
5UTR-5UTRENST00000461529ENST00000472642PRKAG2chr7

151478238

-RHEBchr7

151188100

-
5UTR-5UTRENST00000461529ENST00000496004PRKAG2chr7

151478238

-RHEBchr7

151188100

-
In-frameENST00000287878ENST00000262187PRKAG2chr7

151329155

-RHEBchr7

151188100

-
5CDS-5UTRENST00000287878ENST00000472642PRKAG2chr7

151329155

-RHEBchr7

151188100

-
5CDS-5UTRENST00000287878ENST00000496004PRKAG2chr7

151329155

-RHEBchr7

151188100

-
Frame-shiftENST00000418337ENST00000262187PRKAG2chr7

151329155

-RHEBchr7

151188100

-
5CDS-5UTRENST00000418337ENST00000472642PRKAG2chr7

151329155

-RHEBchr7

151188100

-
5CDS-5UTRENST00000418337ENST00000496004PRKAG2chr7

151329155

-RHEBchr7

151188100

-
In-frameENST00000433631ENST00000262187PRKAG2chr7

151329155

-RHEBchr7

151188100

-
5CDS-5UTRENST00000433631ENST00000472642PRKAG2chr7

151329155

-RHEBchr7

151188100

-
5CDS-5UTRENST00000433631ENST00000496004PRKAG2chr7

151329155

-RHEBchr7

151188100

-
In-frameENST00000492843ENST00000262187PRKAG2chr7

151329155

-RHEBchr7

151188100

-
5CDS-5UTRENST00000492843ENST00000472642PRKAG2chr7

151329155

-RHEBchr7

151188100

-
5CDS-5UTRENST00000492843ENST00000496004PRKAG2chr7

151329155

-RHEBchr7

151188100

-
Frame-shiftENST00000392801ENST00000262187PRKAG2chr7

151329155

-RHEBchr7

151188100

-
5CDS-5UTRENST00000392801ENST00000472642PRKAG2chr7

151329155

-RHEBchr7

151188100

-
5CDS-5UTRENST00000392801ENST00000496004PRKAG2chr7

151329155

-RHEBchr7

151188100

-
intron-3CDSENST00000461529ENST00000262187PRKAG2chr7

151329155

-RHEBchr7

151188100

-
intron-5UTRENST00000461529ENST00000472642PRKAG2chr7

151329155

-RHEBchr7

151188100

-
intron-5UTRENST00000461529ENST00000496004PRKAG2chr7

151329155

-RHEBchr7

151188100

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000287878PRKAG2chr7151478238-ENST00000262187RHEBchr7151188100-25819714931473326
ENST00000287878PRKAG2chr7151329155-ENST00000262187RHEBchr7151188100-286912594931761422
ENST00000433631PRKAG2chr7151329155-ENST00000262187RHEBchr7151188100-22626522401154304
ENST00000492843PRKAG2chr7151329155-ENST00000262187RHEBchr7151188100-23137032911205304

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000287878ENST00000262187PRKAG2chr7151478238-RHEBchr7151188100-0.0007783540.9992217
ENST00000287878ENST00000262187PRKAG2chr7151329155-RHEBchr7151188100-0.00132180.99867815
ENST00000433631ENST00000262187PRKAG2chr7151329155-RHEBchr7151188100-0.0040072150.9959928
ENST00000492843ENST00000262187PRKAG2chr7151329155-RHEBchr7151188100-0.0041642690.9958358

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Fusion Genomic Features for PRKAG2-RHEB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PRKAG2-RHEB


check button Go to

FGviewer for the breakpoints of chr7:151478238-chr7:151188100

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRHEBchr7:151329155chr7:151188100ENST000002621870835_4317.333333333333332185.0MotifEffector region
TgeneRHEBchr7:151478238chr7:151188100ENST000002621870835_4317.333333333333332185.0MotifEffector region
TgeneRHEBchr7:151329155chr7:151188100ENST0000026218708119_12217.333333333333332185.0Nucleotide bindingGTP
TgeneRHEBchr7:151329155chr7:151188100ENST0000026218708149_15017.333333333333332185.0Nucleotide bindingGTP
TgeneRHEBchr7:151329155chr7:151188100ENST000002621870816_2117.333333333333332185.0Nucleotide bindingGTP
TgeneRHEBchr7:151329155chr7:151188100ENST000002621870832_3817.333333333333332185.0Nucleotide bindingGTP
TgeneRHEBchr7:151478238chr7:151188100ENST0000026218708119_12217.333333333333332185.0Nucleotide bindingGTP
TgeneRHEBchr7:151478238chr7:151188100ENST0000026218708149_15017.333333333333332185.0Nucleotide bindingGTP
TgeneRHEBchr7:151478238chr7:151188100ENST000002621870816_2117.333333333333332185.0Nucleotide bindingGTP
TgeneRHEBchr7:151478238chr7:151188100ENST000002621870832_3817.333333333333332185.0Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRKAG2chr7:151329155chr7:151188100ENST00000287878-516275_335251.33333333333334570.0DomainCBS 1
HgenePRKAG2chr7:151329155chr7:151188100ENST00000287878-516357_415251.33333333333334570.0DomainCBS 2
HgenePRKAG2chr7:151329155chr7:151188100ENST00000287878-516430_492251.33333333333334570.0DomainCBS 3
HgenePRKAG2chr7:151329155chr7:151188100ENST00000287878-516504_562251.33333333333334570.0DomainCBS 4
HgenePRKAG2chr7:151329155chr7:151188100ENST00000392801-516275_335207.33333333333334526.0DomainCBS 1
HgenePRKAG2chr7:151329155chr7:151188100ENST00000392801-516357_415207.33333333333334526.0DomainCBS 2
HgenePRKAG2chr7:151329155chr7:151188100ENST00000392801-516430_492207.33333333333334526.0DomainCBS 3
HgenePRKAG2chr7:151329155chr7:151188100ENST00000392801-516504_562207.33333333333334526.0DomainCBS 4
HgenePRKAG2chr7:151329155chr7:151188100ENST00000418337-112275_33510.333333333333334329.0DomainCBS 1
HgenePRKAG2chr7:151329155chr7:151188100ENST00000418337-112357_41510.333333333333334329.0DomainCBS 2
HgenePRKAG2chr7:151329155chr7:151188100ENST00000418337-112430_49210.333333333333334329.0DomainCBS 3
HgenePRKAG2chr7:151329155chr7:151188100ENST00000418337-112504_56210.333333333333334329.0DomainCBS 4
HgenePRKAG2chr7:151478238chr7:151188100ENST00000287878-316275_335155.33333333333334570.0DomainCBS 1
HgenePRKAG2chr7:151478238chr7:151188100ENST00000287878-316357_415155.33333333333334570.0DomainCBS 2
HgenePRKAG2chr7:151478238chr7:151188100ENST00000287878-316430_492155.33333333333334570.0DomainCBS 3
HgenePRKAG2chr7:151478238chr7:151188100ENST00000287878-316504_562155.33333333333334570.0DomainCBS 4
HgenePRKAG2chr7:151478238chr7:151188100ENST00000392801-316275_335111.33333333333333526.0DomainCBS 1
HgenePRKAG2chr7:151478238chr7:151188100ENST00000392801-316357_415111.33333333333333526.0DomainCBS 2
HgenePRKAG2chr7:151478238chr7:151188100ENST00000392801-316430_492111.33333333333333526.0DomainCBS 3
HgenePRKAG2chr7:151478238chr7:151188100ENST00000392801-316504_562111.33333333333333526.0DomainCBS 4
HgenePRKAG2chr7:151478238chr7:151188100ENST00000418337-112275_3350329.0DomainCBS 1
HgenePRKAG2chr7:151478238chr7:151188100ENST00000418337-112357_4150329.0DomainCBS 2
HgenePRKAG2chr7:151478238chr7:151188100ENST00000418337-112430_4920329.0DomainCBS 3
HgenePRKAG2chr7:151478238chr7:151188100ENST00000418337-112504_5620329.0DomainCBS 4
HgenePRKAG2chr7:151329155chr7:151188100ENST00000287878-516370_391251.33333333333334570.0MotifNote=AMPK pseudosubstrate
HgenePRKAG2chr7:151329155chr7:151188100ENST00000392801-516370_391207.33333333333334526.0MotifNote=AMPK pseudosubstrate
HgenePRKAG2chr7:151329155chr7:151188100ENST00000418337-112370_39110.333333333333334329.0MotifNote=AMPK pseudosubstrate
HgenePRKAG2chr7:151478238chr7:151188100ENST00000287878-316370_391155.33333333333334570.0MotifNote=AMPK pseudosubstrate
HgenePRKAG2chr7:151478238chr7:151188100ENST00000392801-316370_391111.33333333333333526.0MotifNote=AMPK pseudosubstrate
HgenePRKAG2chr7:151478238chr7:151188100ENST00000418337-112370_3910329.0MotifNote=AMPK pseudosubstrate
HgenePRKAG2chr7:151329155chr7:151188100ENST00000287878-516319_322251.33333333333334570.0Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151329155chr7:151188100ENST00000287878-516383_384251.33333333333334570.0Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151329155chr7:151188100ENST00000287878-516458_459251.33333333333334570.0Nucleotide bindingAMP 3
HgenePRKAG2chr7:151329155chr7:151188100ENST00000287878-516474_477251.33333333333334570.0Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151329155chr7:151188100ENST00000287878-516530_531251.33333333333334570.0Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151329155chr7:151188100ENST00000287878-516546_549251.33333333333334570.0Nucleotide bindingAMP 3
HgenePRKAG2chr7:151329155chr7:151188100ENST00000392801-516319_322207.33333333333334526.0Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151329155chr7:151188100ENST00000392801-516383_384207.33333333333334526.0Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151329155chr7:151188100ENST00000392801-516458_459207.33333333333334526.0Nucleotide bindingAMP 3
HgenePRKAG2chr7:151329155chr7:151188100ENST00000392801-516474_477207.33333333333334526.0Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151329155chr7:151188100ENST00000392801-516530_531207.33333333333334526.0Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151329155chr7:151188100ENST00000392801-516546_549207.33333333333334526.0Nucleotide bindingAMP 3
HgenePRKAG2chr7:151329155chr7:151188100ENST00000418337-112319_32210.333333333333334329.0Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151329155chr7:151188100ENST00000418337-112383_38410.333333333333334329.0Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151329155chr7:151188100ENST00000418337-112458_45910.333333333333334329.0Nucleotide bindingAMP 3
HgenePRKAG2chr7:151329155chr7:151188100ENST00000418337-112474_47710.333333333333334329.0Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151329155chr7:151188100ENST00000418337-112530_53110.333333333333334329.0Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151329155chr7:151188100ENST00000418337-112546_54910.333333333333334329.0Nucleotide bindingAMP 3
HgenePRKAG2chr7:151478238chr7:151188100ENST00000287878-316319_322155.33333333333334570.0Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151478238chr7:151188100ENST00000287878-316383_384155.33333333333334570.0Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151478238chr7:151188100ENST00000287878-316458_459155.33333333333334570.0Nucleotide bindingAMP 3
HgenePRKAG2chr7:151478238chr7:151188100ENST00000287878-316474_477155.33333333333334570.0Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151478238chr7:151188100ENST00000287878-316530_531155.33333333333334570.0Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151478238chr7:151188100ENST00000287878-316546_549155.33333333333334570.0Nucleotide bindingAMP 3
HgenePRKAG2chr7:151478238chr7:151188100ENST00000392801-316319_322111.33333333333333526.0Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151478238chr7:151188100ENST00000392801-316383_384111.33333333333333526.0Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151478238chr7:151188100ENST00000392801-316458_459111.33333333333333526.0Nucleotide bindingAMP 3
HgenePRKAG2chr7:151478238chr7:151188100ENST00000392801-316474_477111.33333333333333526.0Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151478238chr7:151188100ENST00000392801-316530_531111.33333333333333526.0Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151478238chr7:151188100ENST00000392801-316546_549111.33333333333333526.0Nucleotide bindingAMP 3
HgenePRKAG2chr7:151478238chr7:151188100ENST00000418337-112319_3220329.0Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151478238chr7:151188100ENST00000418337-112383_3840329.0Nucleotide bindingAMP%2C ADP or ATP 1
HgenePRKAG2chr7:151478238chr7:151188100ENST00000418337-112458_4590329.0Nucleotide bindingAMP 3
HgenePRKAG2chr7:151478238chr7:151188100ENST00000418337-112474_4770329.0Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151478238chr7:151188100ENST00000418337-112530_5310329.0Nucleotide bindingAMP%2C ADP or ATP 2
HgenePRKAG2chr7:151478238chr7:151188100ENST00000418337-112546_5490329.0Nucleotide bindingAMP 3


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Fusion Gene Sequence for PRKAG2-RHEB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000287878_ENST00000262187_TCGA-DD-A1ED-01A_PRKAG2_chr7_151478238_-_RHEB_chr7_151188100_length(transcript)=2581nt_BP=971nt
GAGCTGGTTTATTCTGCGGCCGAGGATTACATTTATGCACGAACGGGCTTACTGGTTCCAGATTCCCCACTTGGGCACAGGCATAGGAGG
CTTGTTTTCCAAATTGCTGGTTTTAATTGCACCTGCCTTTCAGATTACCTCTGGGAATCTGTGGGAGGAGCCGAGAGGGTGGAAAATGTT
TCTTAGCTTTGCAAAAGGAAGAAAACTTTGTCACCCAGCGGGAGACCTCAGCCACGAGTAACCCGGGGAGACACCAGAACCGGGACGGGC
TTTGACTGATTTGCCTACGAGGGTTCCGTAGGAAAGGACGCTTGAATTCGGCGCTTCGGCGGCGGCGGCGGCCGCGCGAGTTCCCTGCTC
ACCCTCCCTCTCCGCGGAAGTCCCCACGAGGTGGCTTCAGGGTGTAACAGAGCGCGCGGCTCCAGTCCGAAGGCAGCGGCCGGGGGAGGG
AAGGAGGGGACCGAACCCCCGAGGAGTTTCGCAGAATCAACTTCTGGTTAGAGTTATGGGAAGCGCGGTTATGGACACCAAGAAGAAAAA
AGATGTTTCCAGCCCCGGCGGGAGCGGCGGCAAGAAAAATGCCAGCCAGAAGAGGCGTTCGCTGCGCGTGCACATTCCGGACCTGAGCTC
CTTCGCCATGCCGCTCCTGGACGGAGACCTGGAGGGTTCCGGAAAGCATTCCTCTCGAAAGGTGGACAGCCCCTTCGGCCCGGGCAGCCC
CTCCAAAGGGTTCTTCTCCAGAGGCCCCCAGCCCCGGCCCTCCAGCCCCATGTCTGCACCTGTGAGGCCCAAGACCAGCCCCGGCTCTCC
CAAAACCGTGTTCCCGTTCTCCTACCAGGAGTCCCCGCCACGCTCCCCTCGACGCATGAGCTTCAGTGGGATCTTCCGCTCCTCCTCCAA
AGAGTCTTCCCCCAACTCCAACCCTGCTACCTCGCCCGGGGGCATCAGGTTTTTCTCCCGCTCCAGAAAAAGGAAATCCTCATTGACGAT
TCAATTTGTTGAAGGCCAATTTGTGGACTCCTACGATCCAACCATAGAAAACACTTTTACAAAGTTGATCACAGTAAATGGACAAGAATA
TCATCTTCAACTTGTAGACACAGCCGGGCAAGATGAATATTCTATCTTTCCTCAGACATACTCCATAGATATTAATGGCTATATTCTTGT
GTATTCTGTTACATCAATCAAAAGTTTTGAAGTGATTAAAGTTATCCATGGCAAATTGTTGGATATGGTGGGGAAAGTACAAATACCTAT
TATGTTGGTTGGGAATAAGAAAGACCTGCATATGGAAAGGGTGATCAGTTATGAAGAAGGGAAAGCTTTGGCAGAATCTTGGAATGCAGC
TTTTTTGGAATCTTCTGCTAAAGAAAATCAGACTGCTGTGGATGTTTTTCGAAGGATAATTTTGGAGGCAGAAAAAATGGACGGGGCAGC
TTCACAAGGCAAGTCTTCATGCTCGGTGATGTGATTCTGCTGCAAAGCCTGAGGACACTGGGAATATATTCTACCTGAAGAAGCAAACTG
CCCGTTCTCCTTGAAGATAAACTATGCTTCTTTTTTCTTCTGTTAACCTGAAAGATATCATTTGGGTCAGAGCTCCCCTCCCTTCAGATT
ATGTTAACTCTGAGTCTGTCCAAATGAGTTCACTTCCATTTTCAAATTTTAAGCAATCATATTTTCAATTTATATATTGTATTTCTTAAT
ATTATGACCAAGAATTTTATCGGCATTAATTTTTCAGTGTAGTTTGTTGTTTAAAATAATGTAATCATCAAAATGATGCATATTGTTACA
CTACTATTAACTAGGCTTCAGTATATCAGTGTTTATTTCATTGTGTTAAATGTATACTTGTAAATAAAATAGCTGCAAACCTCAGTCCTT
TGTGCTACTTGATGTGGCTTTCAAAGAAGAGAAGCCTTGTCCTGAGTTTCTCACTTGGCTTCAGGAAGGCCCCAGGTTGGATTCCAGAAA
CCAGTGAAGATGTGGCCACAGGAGGAGGTGTGCTGAGGTGGCTGCTGACCGTGGACTCCCTGCGCAGTGGCCTGCAGATGTTGGGGCTGG
GTTACAGCTGATTGAAGCTGAGTGGCCCTGGGGGGTCTGTGAGGGGAGTTCCTCCCCAGTGATGAAATTCTCTCCTTCCACCCTCAAATC
CCTAGACCTTGACTGAAATGCTCCGTGGTCGGGAGCCTGGTCAAGGAGGAGGAGCTGCTGAGAGGCATTGTTCGCCCTTGCTCATAGCTT
AGCTCGATGTCCGTGTCAGACAGGAGATGATTGAGAACAGCCTTGCCTGTCACTGTCCTAGAACACCCTGGAGTTTAGTGTTCTGTGTCA
GAGTCTTGGGAGCCTCCTTCAGACCCAGATGACGGGCCTCCCTCTGTCCAAGGAGCAGCTGTAAAGGAGAAGAGGGATTTCATTTGTTTG
GTGGCTGTTACCTTGTCTGTAAGTCAAACTTGGAGTTGAGCAGTGCTTTTTAAACGATTCCCTTTTGCAGCTAAAATTTCACAGGGCTAT

>In-frame_ENST00000287878_ENST00000262187_TCGA-DD-A1ED-01A_PRKAG2_chr7_151478238_-_RHEB_chr7_151188100_length(amino acids)=326AA_start in transcript=493_stop in transcript=1473
MVRVMGSAVMDTKKKKDVSSPGGSGGKKNASQKRRSLRVHIPDLSSFAMPLLDGDLEGSGKHSSRKVDSPFGPGSPSKGFFSRGPQPRPS
SPMSAPVRPKTSPGSPKTVFPFSYQESPPRSPRRMSFSGIFRSSSKESSPNSNPATSPGGIRFFSRSRKRKSSLTIQFVEGQFVDSYDPT
IENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERV

--------------------------------------------------------------
>In-frame_ENST00000287878_ENST00000262187_TCGA-BR-8059-01A_PRKAG2_chr7_151329155_-_RHEB_chr7_151188100_length(transcript)=2869nt_BP=1259nt
GAGCTGGTTTATTCTGCGGCCGAGGATTACATTTATGCACGAACGGGCTTACTGGTTCCAGATTCCCCACTTGGGCACAGGCATAGGAGG
CTTGTTTTCCAAATTGCTGGTTTTAATTGCACCTGCCTTTCAGATTACCTCTGGGAATCTGTGGGAGGAGCCGAGAGGGTGGAAAATGTT
TCTTAGCTTTGCAAAAGGAAGAAAACTTTGTCACCCAGCGGGAGACCTCAGCCACGAGTAACCCGGGGAGACACCAGAACCGGGACGGGC
TTTGACTGATTTGCCTACGAGGGTTCCGTAGGAAAGGACGCTTGAATTCGGCGCTTCGGCGGCGGCGGCGGCCGCGCGAGTTCCCTGCTC
ACCCTCCCTCTCCGCGGAAGTCCCCACGAGGTGGCTTCAGGGTGTAACAGAGCGCGCGGCTCCAGTCCGAAGGCAGCGGCCGGGGGAGGG
AAGGAGGGGACCGAACCCCCGAGGAGTTTCGCAGAATCAACTTCTGGTTAGAGTTATGGGAAGCGCGGTTATGGACACCAAGAAGAAAAA
AGATGTTTCCAGCCCCGGCGGGAGCGGCGGCAAGAAAAATGCCAGCCAGAAGAGGCGTTCGCTGCGCGTGCACATTCCGGACCTGAGCTC
CTTCGCCATGCCGCTCCTGGACGGAGACCTGGAGGGTTCCGGAAAGCATTCCTCTCGAAAGGTGGACAGCCCCTTCGGCCCGGGCAGCCC
CTCCAAAGGGTTCTTCTCCAGAGGCCCCCAGCCCCGGCCCTCCAGCCCCATGTCTGCACCTGTGAGGCCCAAGACCAGCCCCGGCTCTCC
CAAAACCGTGTTCCCGTTCTCCTACCAGGAGTCCCCGCCACGCTCCCCTCGACGCATGAGCTTCAGTGGGATCTTCCGCTCCTCCTCCAA
AGAGTCTTCCCCCAACTCCAACCCTGCTACCTCGCCCGGGGGCATCAGGTTTTTCTCCCGCTCCAGAAAAACCTCCGGCCTCTCCTCCTC
TCCGTCAACACCCACCCAAGTGACCAAGCAGCACACGTTTCCCCTGGAATCCTATAAGCACGAGCCTGAACGGTTAGAGAATCGCATCTA
TGCCTCGTCTTCCCCCCCGGACACAGGGCAGAGGTTCTGCCCGTCTTCCTTCCAGAGCCCGACCAGGCCTCCACTGGCATCACCGACACA
CTATGCTCCCTCCAAAGCCGCGGCGCTGGCGGCGGCCCTGGGACCCGCGGAAGCCGGCATGCTGGAGAAGCTGGAGTTCGAGGACGAAGG
GAAATCCTCATTGACGATTCAATTTGTTGAAGGCCAATTTGTGGACTCCTACGATCCAACCATAGAAAACACTTTTACAAAGTTGATCAC
AGTAAATGGACAAGAATATCATCTTCAACTTGTAGACACAGCCGGGCAAGATGAATATTCTATCTTTCCTCAGACATACTCCATAGATAT
TAATGGCTATATTCTTGTGTATTCTGTTACATCAATCAAAAGTTTTGAAGTGATTAAAGTTATCCATGGCAAATTGTTGGATATGGTGGG
GAAAGTACAAATACCTATTATGTTGGTTGGGAATAAGAAAGACCTGCATATGGAAAGGGTGATCAGTTATGAAGAAGGGAAAGCTTTGGC
AGAATCTTGGAATGCAGCTTTTTTGGAATCTTCTGCTAAAGAAAATCAGACTGCTGTGGATGTTTTTCGAAGGATAATTTTGGAGGCAGA
AAAAATGGACGGGGCAGCTTCACAAGGCAAGTCTTCATGCTCGGTGATGTGATTCTGCTGCAAAGCCTGAGGACACTGGGAATATATTCT
ACCTGAAGAAGCAAACTGCCCGTTCTCCTTGAAGATAAACTATGCTTCTTTTTTCTTCTGTTAACCTGAAAGATATCATTTGGGTCAGAG
CTCCCCTCCCTTCAGATTATGTTAACTCTGAGTCTGTCCAAATGAGTTCACTTCCATTTTCAAATTTTAAGCAATCATATTTTCAATTTA
TATATTGTATTTCTTAATATTATGACCAAGAATTTTATCGGCATTAATTTTTCAGTGTAGTTTGTTGTTTAAAATAATGTAATCATCAAA
ATGATGCATATTGTTACACTACTATTAACTAGGCTTCAGTATATCAGTGTTTATTTCATTGTGTTAAATGTATACTTGTAAATAAAATAG
CTGCAAACCTCAGTCCTTTGTGCTACTTGATGTGGCTTTCAAAGAAGAGAAGCCTTGTCCTGAGTTTCTCACTTGGCTTCAGGAAGGCCC
CAGGTTGGATTCCAGAAACCAGTGAAGATGTGGCCACAGGAGGAGGTGTGCTGAGGTGGCTGCTGACCGTGGACTCCCTGCGCAGTGGCC
TGCAGATGTTGGGGCTGGGTTACAGCTGATTGAAGCTGAGTGGCCCTGGGGGGTCTGTGAGGGGAGTTCCTCCCCAGTGATGAAATTCTC
TCCTTCCACCCTCAAATCCCTAGACCTTGACTGAAATGCTCCGTGGTCGGGAGCCTGGTCAAGGAGGAGGAGCTGCTGAGAGGCATTGTT
CGCCCTTGCTCATAGCTTAGCTCGATGTCCGTGTCAGACAGGAGATGATTGAGAACAGCCTTGCCTGTCACTGTCCTAGAACACCCTGGA
GTTTAGTGTTCTGTGTCAGAGTCTTGGGAGCCTCCTTCAGACCCAGATGACGGGCCTCCCTCTGTCCAAGGAGCAGCTGTAAAGGAGAAG
AGGGATTTCATTTGTTTGGTGGCTGTTACCTTGTCTGTAAGTCAAACTTGGAGTTGAGCAGTGCTTTTTAAACGATTCCCTTTTGCAGCT

>In-frame_ENST00000287878_ENST00000262187_TCGA-BR-8059-01A_PRKAG2_chr7_151329155_-_RHEB_chr7_151188100_length(amino acids)=422AA_start in transcript=493_stop in transcript=1761
MVRVMGSAVMDTKKKKDVSSPGGSGGKKNASQKRRSLRVHIPDLSSFAMPLLDGDLEGSGKHSSRKVDSPFGPGSPSKGFFSRGPQPRPS
SPMSAPVRPKTSPGSPKTVFPFSYQESPPRSPRRMSFSGIFRSSSKESSPNSNPATSPGGIRFFSRSRKTSGLSSSPSTPTQVTKQHTFP
LESYKHEPERLENRIYASSSPPDTGQRFCPSSFQSPTRPPLASPTHYAPSKAAALAAALGPAEAGMLEKLEFEDEGKSSLTIQFVEGQFV
DSYDPTIENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKD

--------------------------------------------------------------
>In-frame_ENST00000433631_ENST00000262187_TCGA-BR-8059-01A_PRKAG2_chr7_151329155_-_RHEB_chr7_151188100_length(transcript)=2262nt_BP=652nt
GCTGTGGCCGGAGGTGCAGCCCCGTCAGGACGGCTCCACTCCCTGGCGCCTCACAGACTCTGGGGCTGCGGTGAGGTCGCCCTGAAGACC
CCCTGGTGAGGACGCTTGAACCCGGGCTGTCACCTGAGCACAGGCTGCCACTCTGAGCTTTTGGGGCGCCCTGTGCCTGTCGGGCTGATG
CTCCTCTGGCTCCCGGCCACCTGGGGCTGACACCGGTTCTGTGGGTCCTGATATGTTCACCTGTCGCCACTCCTGTGGCCACAGCTACCC
ATGAAGCGCTTTGGGAGCCTCAGGAGCAACAAGAAACACAAGGACCAAAATCGAAGCACGGAGAGGCGCCAGTCGGAGCCTCATGGCCTT
TTCGCCTCCGGCCTCTCCTCCTCTCCGTCAACACCCACCCAAGTGACCAAGCAGCACACGTTTCCCCTGGAATCCTATAAGCACGAGCCT
GAACGGTTAGAGAATCGCATCTATGCCTCGTCTTCCCCCCCGGACACAGGGCAGAGGTTCTGCCCGTCTTCCTTCCAGAGCCCGACCAGG
CCTCCACTGGCATCACCGACACACTATGCTCCCTCCAAAGCCGCGGCGCTGGCGGCGGCCCTGGGACCCGCGGAAGCCGGCATGCTGGAG
AAGCTGGAGTTCGAGGACGAAGGGAAATCCTCATTGACGATTCAATTTGTTGAAGGCCAATTTGTGGACTCCTACGATCCAACCATAGAA
AACACTTTTACAAAGTTGATCACAGTAAATGGACAAGAATATCATCTTCAACTTGTAGACACAGCCGGGCAAGATGAATATTCTATCTTT
CCTCAGACATACTCCATAGATATTAATGGCTATATTCTTGTGTATTCTGTTACATCAATCAAAAGTTTTGAAGTGATTAAAGTTATCCAT
GGCAAATTGTTGGATATGGTGGGGAAAGTACAAATACCTATTATGTTGGTTGGGAATAAGAAAGACCTGCATATGGAAAGGGTGATCAGT
TATGAAGAAGGGAAAGCTTTGGCAGAATCTTGGAATGCAGCTTTTTTGGAATCTTCTGCTAAAGAAAATCAGACTGCTGTGGATGTTTTT
CGAAGGATAATTTTGGAGGCAGAAAAAATGGACGGGGCAGCTTCACAAGGCAAGTCTTCATGCTCGGTGATGTGATTCTGCTGCAAAGCC
TGAGGACACTGGGAATATATTCTACCTGAAGAAGCAAACTGCCCGTTCTCCTTGAAGATAAACTATGCTTCTTTTTTCTTCTGTTAACCT
GAAAGATATCATTTGGGTCAGAGCTCCCCTCCCTTCAGATTATGTTAACTCTGAGTCTGTCCAAATGAGTTCACTTCCATTTTCAAATTT
TAAGCAATCATATTTTCAATTTATATATTGTATTTCTTAATATTATGACCAAGAATTTTATCGGCATTAATTTTTCAGTGTAGTTTGTTG
TTTAAAATAATGTAATCATCAAAATGATGCATATTGTTACACTACTATTAACTAGGCTTCAGTATATCAGTGTTTATTTCATTGTGTTAA
ATGTATACTTGTAAATAAAATAGCTGCAAACCTCAGTCCTTTGTGCTACTTGATGTGGCTTTCAAAGAAGAGAAGCCTTGTCCTGAGTTT
CTCACTTGGCTTCAGGAAGGCCCCAGGTTGGATTCCAGAAACCAGTGAAGATGTGGCCACAGGAGGAGGTGTGCTGAGGTGGCTGCTGAC
CGTGGACTCCCTGCGCAGTGGCCTGCAGATGTTGGGGCTGGGTTACAGCTGATTGAAGCTGAGTGGCCCTGGGGGGTCTGTGAGGGGAGT
TCCTCCCCAGTGATGAAATTCTCTCCTTCCACCCTCAAATCCCTAGACCTTGACTGAAATGCTCCGTGGTCGGGAGCCTGGTCAAGGAGG
AGGAGCTGCTGAGAGGCATTGTTCGCCCTTGCTCATAGCTTAGCTCGATGTCCGTGTCAGACAGGAGATGATTGAGAACAGCCTTGCCTG
TCACTGTCCTAGAACACCCTGGAGTTTAGTGTTCTGTGTCAGAGTCTTGGGAGCCTCCTTCAGACCCAGATGACGGGCCTCCCTCTGTCC
AAGGAGCAGCTGTAAAGGAGAAGAGGGATTTCATTTGTTTGGTGGCTGTTACCTTGTCTGTAAGTCAAACTTGGAGTTGAGCAGTGCTTT
TTAAACGATTCCCTTTTGCAGCTAAAATTTCACAGGGCTATTTCTAATACGTAAGCAAATGTTACCATTGACTTTATTAATAAAATATAG

>In-frame_ENST00000433631_ENST00000262187_TCGA-BR-8059-01A_PRKAG2_chr7_151329155_-_RHEB_chr7_151188100_length(amino acids)=304AA_start in transcript=240_stop in transcript=1154
MSPLLWPQLPMKRFGSLRSNKKHKDQNRSTERRQSEPHGLFASGLSSSPSTPTQVTKQHTFPLESYKHEPERLENRIYASSSPPDTGQRF
CPSSFQSPTRPPLASPTHYAPSKAAALAAALGPAEAGMLEKLEFEDEGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVD
TAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSA

--------------------------------------------------------------
>In-frame_ENST00000492843_ENST00000262187_TCGA-BR-8059-01A_PRKAG2_chr7_151329155_-_RHEB_chr7_151188100_length(transcript)=2313nt_BP=703nt
GCTTCCGGCAGCTTCTTGCTACTTAAGGACAGCCGGGCTGACGCTCCAGCTGCTGTGGCCGGAGGTGCAGCCCCGTCAGGACGGCTCCAC
TCCCTGGCGCCTCACAGACTCTGGGGCTGCGGTGAGGTCGCCCTGAAGACCCCCTGGTGAGGACGCTTGAACCCGGGCTGTCACCTGAGC
ACAGGCTGCCACTCTGAGCTTTTGGGGCGCCCTGTGCCTGTCGGGCTGATGCTCCTCTGGCTCCCGGCCACCTGGGGCTGACACCGGTTC
TGTGGGTCCTGATATGTTCACCTGTCGCCACTCCTGTGGCCACAGCTACCCATGAAGCGCTTTGGGAGCCTCAGGAGCAACAAGAAACAC
AAGGACCAAAATCGAAGCACGGAGAGGCGCCAGTCGGAGCCTCATGGCCTTTTCGCCTCCGGCCTCTCCTCCTCTCCGTCAACACCCACC
CAAGTGACCAAGCAGCACACGTTTCCCCTGGAATCCTATAAGCACGAGCCTGAACGGTTAGAGAATCGCATCTATGCCTCGTCTTCCCCC
CCGGACACAGGGCAGAGGTTCTGCCCGTCTTCCTTCCAGAGCCCGACCAGGCCTCCACTGGCATCACCGACACACTATGCTCCCTCCAAA
GCCGCGGCGCTGGCGGCGGCCCTGGGACCCGCGGAAGCCGGCATGCTGGAGAAGCTGGAGTTCGAGGACGAAGGGAAATCCTCATTGACG
ATTCAATTTGTTGAAGGCCAATTTGTGGACTCCTACGATCCAACCATAGAAAACACTTTTACAAAGTTGATCACAGTAAATGGACAAGAA
TATCATCTTCAACTTGTAGACACAGCCGGGCAAGATGAATATTCTATCTTTCCTCAGACATACTCCATAGATATTAATGGCTATATTCTT
GTGTATTCTGTTACATCAATCAAAAGTTTTGAAGTGATTAAAGTTATCCATGGCAAATTGTTGGATATGGTGGGGAAAGTACAAATACCT
ATTATGTTGGTTGGGAATAAGAAAGACCTGCATATGGAAAGGGTGATCAGTTATGAAGAAGGGAAAGCTTTGGCAGAATCTTGGAATGCA
GCTTTTTTGGAATCTTCTGCTAAAGAAAATCAGACTGCTGTGGATGTTTTTCGAAGGATAATTTTGGAGGCAGAAAAAATGGACGGGGCA
GCTTCACAAGGCAAGTCTTCATGCTCGGTGATGTGATTCTGCTGCAAAGCCTGAGGACACTGGGAATATATTCTACCTGAAGAAGCAAAC
TGCCCGTTCTCCTTGAAGATAAACTATGCTTCTTTTTTCTTCTGTTAACCTGAAAGATATCATTTGGGTCAGAGCTCCCCTCCCTTCAGA
TTATGTTAACTCTGAGTCTGTCCAAATGAGTTCACTTCCATTTTCAAATTTTAAGCAATCATATTTTCAATTTATATATTGTATTTCTTA
ATATTATGACCAAGAATTTTATCGGCATTAATTTTTCAGTGTAGTTTGTTGTTTAAAATAATGTAATCATCAAAATGATGCATATTGTTA
CACTACTATTAACTAGGCTTCAGTATATCAGTGTTTATTTCATTGTGTTAAATGTATACTTGTAAATAAAATAGCTGCAAACCTCAGTCC
TTTGTGCTACTTGATGTGGCTTTCAAAGAAGAGAAGCCTTGTCCTGAGTTTCTCACTTGGCTTCAGGAAGGCCCCAGGTTGGATTCCAGA
AACCAGTGAAGATGTGGCCACAGGAGGAGGTGTGCTGAGGTGGCTGCTGACCGTGGACTCCCTGCGCAGTGGCCTGCAGATGTTGGGGCT
GGGTTACAGCTGATTGAAGCTGAGTGGCCCTGGGGGGTCTGTGAGGGGAGTTCCTCCCCAGTGATGAAATTCTCTCCTTCCACCCTCAAA
TCCCTAGACCTTGACTGAAATGCTCCGTGGTCGGGAGCCTGGTCAAGGAGGAGGAGCTGCTGAGAGGCATTGTTCGCCCTTGCTCATAGC
TTAGCTCGATGTCCGTGTCAGACAGGAGATGATTGAGAACAGCCTTGCCTGTCACTGTCCTAGAACACCCTGGAGTTTAGTGTTCTGTGT
CAGAGTCTTGGGAGCCTCCTTCAGACCCAGATGACGGGCCTCCCTCTGTCCAAGGAGCAGCTGTAAAGGAGAAGAGGGATTTCATTTGTT
TGGTGGCTGTTACCTTGTCTGTAAGTCAAACTTGGAGTTGAGCAGTGCTTTTTAAACGATTCCCTTTTGCAGCTAAAATTTCACAGGGCT

>In-frame_ENST00000492843_ENST00000262187_TCGA-BR-8059-01A_PRKAG2_chr7_151329155_-_RHEB_chr7_151188100_length(amino acids)=304AA_start in transcript=291_stop in transcript=1205
MSPLLWPQLPMKRFGSLRSNKKHKDQNRSTERRQSEPHGLFASGLSSSPSTPTQVTKQHTFPLESYKHEPERLENRIYASSSPPDTGQRF
CPSSFQSPTRPPLASPTHYAPSKAAALAAALGPAEAGMLEKLEFEDEGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVD
TAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSA

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Fusion Gene PPI Analysis for PRKAG2-RHEB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PRKAG2-RHEB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PRKAG2-RHEB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePRKAG2C0007194Hypertrophic Cardiomyopathy15CLINGEN
HgenePRKAG2C0043202Wolff-Parkinson-White Syndrome6CTD_human;GENOMICS_ENGLAND;UNIPROT
HgenePRKAG2C1833236CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 6 (disorder)5CTD_human;GENOMICS_ENGLAND;UNIPROT
HgenePRKAG2C1849813Glycogen Storage Disease of Heart, Lethal Congenital5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRHEBC0007131Non-Small Cell Lung Carcinoma1CTD_human