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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:ARNT-MRPL52 (FusionGDB2 ID:6823) |
Fusion Gene Summary for ARNT-MRPL52 |
Fusion gene summary |
Fusion gene information | Fusion gene name: ARNT-MRPL52 | Fusion gene ID: 6823 | Hgene | Tgene | Gene symbol | ARNT | MRPL52 | Gene ID | 375056 | 122704 |
Gene name | MIA SH3 domain ER export factor 3 | mitochondrial ribosomal protein L52 | |
Synonyms | ARNT|D320|TANGO|TANGO1|UNQ6077 | - | |
Cytomap | 1q41 | 14q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | transport and Golgi organization protein 1 homologC219-reactive peptideMIA family member 3, ER export factormelanoma inhibitory activity family, member 3melanoma inhibitory activity protein 3transport and Golgi organization protein 1 | 39S ribosomal protein L52, mitochondrialL52mtMRP-L52mitochondrial large ribosomal subunit protein mL52 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | P27540 | Q86TS9 | |
Ensembl transtripts involved in fusion gene | ENST00000358595, ENST00000354396, ENST00000515192, ENST00000505755, ENST00000468970, | ENST00000355151, ENST00000397496, ENST00000555345, ENST00000432849, ENST00000553711, ENST00000397505, ENST00000557221, ENST00000311892, ENST00000556840, ENST00000461594, ENST00000555536, | |
Fusion gene scores | * DoF score | 18 X 16 X 9=2592 | 6 X 4 X 5=120 |
# samples | 18 | 6 | |
** MAII score | log2(18/2592*10)=-3.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ARNT [Title/Abstract] AND MRPL52 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ARNT(150818739)-MRPL52(23303381), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | ARNT-MRPL52 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. ARNT-MRPL52 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. ARNT-MRPL52 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ARNT | GO:0002687 | positive regulation of leukocyte migration | 17726152 |
Hgene | ARNT | GO:0007162 | negative regulation of cell adhesion | 17726152 |
Hgene | ARNT | GO:0030336 | negative regulation of cell migration | 17044017 |
Hgene | ARNT | GO:0042060 | wound healing | 17044017 |
Fusion gene breakpoints across ARNT (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across MRPL52 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | KICH | TCGA-KO-8404-01A | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
ChimerDB4 | KICH | TCGA-KO-8404-01A | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
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Fusion Gene ORF analysis for ARNT-MRPL52 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000358595 | ENST00000355151 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000358595 | ENST00000397496 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000358595 | ENST00000555345 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000358595 | ENST00000432849 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000358595 | ENST00000553711 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000358595 | ENST00000397505 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000358595 | ENST00000557221 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
In-frame | ENST00000358595 | ENST00000311892 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000358595 | ENST00000556840 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
5CDS-intron | ENST00000358595 | ENST00000461594 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
5CDS-intron | ENST00000358595 | ENST00000555536 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000354396 | ENST00000355151 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000354396 | ENST00000397496 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000354396 | ENST00000555345 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000354396 | ENST00000432849 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000354396 | ENST00000553711 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000354396 | ENST00000397505 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000354396 | ENST00000557221 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
In-frame | ENST00000354396 | ENST00000311892 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000354396 | ENST00000556840 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
5CDS-intron | ENST00000354396 | ENST00000461594 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
5CDS-intron | ENST00000354396 | ENST00000555536 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000515192 | ENST00000355151 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000515192 | ENST00000397496 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
In-frame | ENST00000515192 | ENST00000555345 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000515192 | ENST00000432849 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
In-frame | ENST00000515192 | ENST00000553711 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
In-frame | ENST00000515192 | ENST00000397505 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
In-frame | ENST00000515192 | ENST00000557221 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000515192 | ENST00000311892 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000515192 | ENST00000556840 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
5CDS-intron | ENST00000515192 | ENST00000461594 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
5CDS-intron | ENST00000515192 | ENST00000555536 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000505755 | ENST00000355151 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000505755 | ENST00000397496 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000505755 | ENST00000555345 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000505755 | ENST00000432849 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000505755 | ENST00000553711 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000505755 | ENST00000397505 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000505755 | ENST00000557221 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
In-frame | ENST00000505755 | ENST00000311892 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
Frame-shift | ENST00000505755 | ENST00000556840 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
5CDS-intron | ENST00000505755 | ENST00000461594 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
5CDS-intron | ENST00000505755 | ENST00000555536 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
intron-3CDS | ENST00000468970 | ENST00000355151 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
intron-3CDS | ENST00000468970 | ENST00000397496 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
intron-3CDS | ENST00000468970 | ENST00000555345 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
intron-3CDS | ENST00000468970 | ENST00000432849 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
intron-3CDS | ENST00000468970 | ENST00000553711 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
intron-3CDS | ENST00000468970 | ENST00000397505 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
intron-3CDS | ENST00000468970 | ENST00000557221 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
intron-3CDS | ENST00000468970 | ENST00000311892 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
intron-3CDS | ENST00000468970 | ENST00000556840 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
intron-intron | ENST00000468970 | ENST00000461594 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
intron-intron | ENST00000468970 | ENST00000555536 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000358595 | ARNT | chr1 | 150818739 | - | ENST00000311892 | MRPL52 | chr14 | 23303381 | + | 1234 | 428 | 102 | 554 | 150 |
ENST00000354396 | ARNT | chr1 | 150818739 | - | ENST00000311892 | MRPL52 | chr14 | 23303381 | + | 1045 | 239 | 12 | 365 | 117 |
ENST00000515192 | ARNT | chr1 | 150818739 | - | ENST00000555345 | MRPL52 | chr14 | 23303381 | + | 970 | 424 | 167 | 550 | 127 |
ENST00000515192 | ARNT | chr1 | 150818739 | - | ENST00000553711 | MRPL52 | chr14 | 23303381 | + | 598 | 424 | 167 | 550 | 127 |
ENST00000515192 | ARNT | chr1 | 150818739 | - | ENST00000397505 | MRPL52 | chr14 | 23303381 | + | 600 | 424 | 167 | 550 | 127 |
ENST00000515192 | ARNT | chr1 | 150818739 | - | ENST00000557221 | MRPL52 | chr14 | 23303381 | + | 1081 | 424 | 167 | 550 | 127 |
ENST00000505755 | ARNT | chr1 | 150818739 | - | ENST00000311892 | MRPL52 | chr14 | 23303381 | + | 1075 | 269 | 42 | 395 | 117 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000358595 | ENST00000311892 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + | 0.033752687 | 0.96624726 |
ENST00000354396 | ENST00000311892 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + | 0.056113224 | 0.9438868 |
ENST00000515192 | ENST00000555345 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + | 0.049943518 | 0.95005643 |
ENST00000515192 | ENST00000553711 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + | 0.016320972 | 0.983679 |
ENST00000515192 | ENST00000397505 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + | 0.016514996 | 0.98348504 |
ENST00000515192 | ENST00000557221 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + | 0.0463266 | 0.9536734 |
ENST00000505755 | ENST00000311892 | ARNT | chr1 | 150818739 | - | MRPL52 | chr14 | 23303381 | + | 0.050942823 | 0.94905716 |
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Fusion Genomic Features for ARNT-MRPL52 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
ARNT | chr1 | 150818738 | - | MRPL52 | chr14 | 23303380 | + | 1.28E-11 | 1 |
ARNT | chr1 | 150818738 | - | MRPL52 | chr14 | 23303380 | + | 1.28E-11 | 1 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ARNT-MRPL52 |
Go to FGviewer for the breakpoints of chr1:150818739-chr14:23303381 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ARNT | MRPL52 |
FUNCTION: Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409). {ECO:0000250|UniProtKB:P53762, ECO:0000269|PubMed:28396409}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000358595 | - | 4 | 22 | 503_507 | 75.66666666666667 | 790.0 | Compositional bias | Note=Poly-Gln |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000358595 | - | 4 | 22 | 710_769 | 75.66666666666667 | 790.0 | Compositional bias | Note=Gln-rich |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000358595 | - | 4 | 22 | 738_741 | 75.66666666666667 | 790.0 | Compositional bias | Note=Poly-Ser |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000358595 | - | 4 | 22 | 99_102 | 75.66666666666667 | 790.0 | Compositional bias | Note=Poly-Arg |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000505755 | - | 4 | 21 | 503_507 | 75.66666666666667 | 775.0 | Compositional bias | Note=Poly-Gln |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000505755 | - | 4 | 21 | 710_769 | 75.66666666666667 | 775.0 | Compositional bias | Note=Gln-rich |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000505755 | - | 4 | 21 | 738_741 | 75.66666666666667 | 775.0 | Compositional bias | Note=Poly-Ser |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000505755 | - | 4 | 21 | 99_102 | 75.66666666666667 | 775.0 | Compositional bias | Note=Poly-Arg |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000515192 | - | 5 | 23 | 503_507 | 66.66666666666667 | 776.0 | Compositional bias | Note=Poly-Gln |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000515192 | - | 5 | 23 | 710_769 | 66.66666666666667 | 776.0 | Compositional bias | Note=Gln-rich |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000515192 | - | 5 | 23 | 738_741 | 66.66666666666667 | 776.0 | Compositional bias | Note=Poly-Ser |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000515192 | - | 5 | 23 | 99_102 | 66.66666666666667 | 776.0 | Compositional bias | Note=Poly-Arg |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000358595 | - | 4 | 22 | 161_235 | 75.66666666666667 | 790.0 | Domain | PAS 1 |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000358595 | - | 4 | 22 | 349_419 | 75.66666666666667 | 790.0 | Domain | PAS 2 |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000358595 | - | 4 | 22 | 424_467 | 75.66666666666667 | 790.0 | Domain | Note=PAC |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000358595 | - | 4 | 22 | 89_142 | 75.66666666666667 | 790.0 | Domain | bHLH |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000505755 | - | 4 | 21 | 161_235 | 75.66666666666667 | 775.0 | Domain | PAS 1 |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000505755 | - | 4 | 21 | 349_419 | 75.66666666666667 | 775.0 | Domain | PAS 2 |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000505755 | - | 4 | 21 | 424_467 | 75.66666666666667 | 775.0 | Domain | Note=PAC |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000505755 | - | 4 | 21 | 89_142 | 75.66666666666667 | 775.0 | Domain | bHLH |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000515192 | - | 5 | 23 | 161_235 | 66.66666666666667 | 776.0 | Domain | PAS 1 |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000515192 | - | 5 | 23 | 349_419 | 66.66666666666667 | 776.0 | Domain | PAS 2 |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000515192 | - | 5 | 23 | 424_467 | 66.66666666666667 | 776.0 | Domain | Note=PAC |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000515192 | - | 5 | 23 | 89_142 | 66.66666666666667 | 776.0 | Domain | bHLH |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000358595 | - | 4 | 22 | 112_168 | 75.66666666666667 | 790.0 | Region | Required for heterodimer formation with HIF1A |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000358595 | - | 4 | 22 | 112_264 | 75.66666666666667 | 790.0 | Region | Required for heterodimer formation with EPAS1 |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000358595 | - | 4 | 22 | 167_171 | 75.66666666666667 | 790.0 | Region | Mediates the transcription activity and dimerization of the AHR:ARNT complex |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000358595 | - | 4 | 22 | 88_128 | 75.66666666666667 | 790.0 | Region | DNA-binding |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000505755 | - | 4 | 21 | 112_168 | 75.66666666666667 | 775.0 | Region | Required for heterodimer formation with HIF1A |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000505755 | - | 4 | 21 | 112_264 | 75.66666666666667 | 775.0 | Region | Required for heterodimer formation with EPAS1 |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000505755 | - | 4 | 21 | 167_171 | 75.66666666666667 | 775.0 | Region | Mediates the transcription activity and dimerization of the AHR:ARNT complex |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000505755 | - | 4 | 21 | 88_128 | 75.66666666666667 | 775.0 | Region | DNA-binding |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000515192 | - | 5 | 23 | 112_168 | 66.66666666666667 | 776.0 | Region | Required for heterodimer formation with HIF1A |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000515192 | - | 5 | 23 | 112_264 | 66.66666666666667 | 776.0 | Region | Required for heterodimer formation with EPAS1 |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000515192 | - | 5 | 23 | 167_171 | 66.66666666666667 | 776.0 | Region | Mediates the transcription activity and dimerization of the AHR:ARNT complex |
Hgene | ARNT | chr1:150818739 | chr14:23303381 | ENST00000515192 | - | 5 | 23 | 88_128 | 66.66666666666667 | 776.0 | Region | DNA-binding |
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Fusion Gene Sequence for ARNT-MRPL52 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000358595_ENST00000311892_TCGA-KO-8404-01A_ARNT_chr1_150818739_-_MRPL52_chr14_23303381_length(transcript)=1234nt_BP=428nt ATATAGGCGGGGTCTCCCCGCCGCAGGGGCTGGGATGCTGGGGGCTGCTGAAGCCGCCATCTTGGATTCCGCGGTAGCGGAGGCGGCGGT CAGGCGCCGCTTCTGGGGAGTGGCCTTTCTTTTCCCCTCCCTCCCGGTTCGGTGGCGGCGGCTCCTCCCACTGGGGGGGGGGGTGGCGCG GCGGCGGTGGCATCTGCGGCCATGGCGGCGACTACTGCCAACCCCGAAATGACATCAGATGTACCATCACTGGGTCCAGCCATTGCCTCT GGAAACTCTGGACCTGGAATTCAAGGTGGAGGAGCCATTGTCCAGAGGGCTATTAAGCGGCGACCAGGGCTGGATTTTGATGATGATGGA GAAGGGAACAGTAAATTTTTGAGGTGTGATGATGATCAGATGTCTAACGATAAGGAGCGGTTTGCCAGAGACGAGTTGTACTGCTGTCAC AGGAAATGGACGCTGGATTACAAGCATGGCAGCTCAGGCAGCAGAAGTTGCAGGAAGAACAAAGGAAGCAGGAAAATGCTCTTAAACCCA AAGGGGCTTCACTGAAGAGCCCACTTCCAAGTCAATAAAAAGCAACTCCTGCCTCCCTTCCTCACCCTGTCTCTGGATTTCTTTTCTATC ACCTAGATGCTTCATCCAGCCAGAAGATAGCCTTCACGTTCCCCATCTGTCTTCAGAGAAAAAGAGCTGGGACACCAAGAACAAGCTGTT AGATCACTGCCTGGGAGGCTTGGCTTAGTACTCTCATCTCTGGTTCCATTCCAGTTCAGCTAAGTCTTGCTTTAAAATTTTTACCTCCTA GCTGGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACAAGATCAGGAGTTCGAGACCAGCCTGG CCAACCCAGCCTGGTCAACATGGTGAAACCCTGTCCCTACTAAAGATACAAACAATTAGCCGGGCGTGGTGGGGTGCGCTTGTAATCCCA GCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTAAACTCGGGAGGTAGAGGTTGCAGTGAGCCAAGGTCACACCATTGCACTCCAACCTG GGCGACAGGGCGAGACTCCGTCTCAAAAAAAAAAAAAAATTTACCTCCTTTGCAGGCCATAGGACTAGCCCAACTATGAGAAATAGCTGT >In-frame_ENST00000358595_ENST00000311892_TCGA-KO-8404-01A_ARNT_chr1_150818739_-_MRPL52_chr14_23303381_length(amino acids)=150AA_start in transcript=102_stop in transcript=554 MGSGLSFPLPPGSVAAAPPTGGGGGAAAVASAAMAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNS -------------------------------------------------------------- >In-frame_ENST00000354396_ENST00000311892_TCGA-KO-8404-01A_ARNT_chr1_150818739_-_MRPL52_chr14_23303381_length(transcript)=1045nt_BP=239nt GCATCTGCGGCCATGGCGGCGACTACTGCCAACCCCGAAATGACATCAGATGTACCATCACTGGGTCCAGCCATTGCCTCTGGAAACTCT GGACCTGGAATTCAAGGTGGAGGAGCCATTGTCCAGAGGGCTATTAAGCGGCGACCAGGGCTGGATTTTGATGATGATGGAGAAGGGAAC AGTAAATTTTTGAGGTGTGATGATGATCAGATGTCTAACGATAAGGAGCGGTTTGCCAGAGACGAGTTGTACTGCTGTCACAGGAAATGG ACGCTGGATTACAAGCATGGCAGCTCAGGCAGCAGAAGTTGCAGGAAGAACAAAGGAAGCAGGAAAATGCTCTTAAACCCAAAGGGGCTT CACTGAAGAGCCCACTTCCAAGTCAATAAAAAGCAACTCCTGCCTCCCTTCCTCACCCTGTCTCTGGATTTCTTTTCTATCACCTAGATG CTTCATCCAGCCAGAAGATAGCCTTCACGTTCCCCATCTGTCTTCAGAGAAAAAGAGCTGGGACACCAAGAACAAGCTGTTAGATCACTG CCTGGGAGGCTTGGCTTAGTACTCTCATCTCTGGTTCCATTCCAGTTCAGCTAAGTCTTGCTTTAAAATTTTTACCTCCTAGCTGGGTGC GGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACAAGATCAGGAGTTCGAGACCAGCCTGGCCAACCCAG CCTGGTCAACATGGTGAAACCCTGTCCCTACTAAAGATACAAACAATTAGCCGGGCGTGGTGGGGTGCGCTTGTAATCCCAGCTACTCAG GAGGCTGAGGCAGGAGAATCGCTTAAACTCGGGAGGTAGAGGTTGCAGTGAGCCAAGGTCACACCATTGCACTCCAACCTGGGCGACAGG GCGAGACTCCGTCTCAAAAAAAAAAAAAAATTTACCTCCTTTGCAGGCCATAGGACTAGCCCAACTATGAGAAATAGCTGTTCTGTGAAC >In-frame_ENST00000354396_ENST00000311892_TCGA-KO-8404-01A_ARNT_chr1_150818739_-_MRPL52_chr14_23303381_length(amino acids)=117AA_start in transcript=12_stop in transcript=365 MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFLRCDDDQMSNDKERFARDELYCCHRKWTLDY -------------------------------------------------------------- >In-frame_ENST00000515192_ENST00000555345_TCGA-KO-8404-01A_ARNT_chr1_150818739_-_MRPL52_chr14_23303381_length(transcript)=970nt_BP=424nt CTTGGATTCCGCGGTAGCGGAGGCGGCGGTCAGGCGCCGCTTCTGGGGAGTGGCCTTTCTTTTCCCCTCCCTCCCGGTTCGGTGGCGGCG GCTCCTCCCACTGGGGGGGGGGGTGGCGCGGCGGCGGTGGCATCTGCGGCCATGGCGGCGACTACTGCCAACCCCGCCTGATCTTGGACT CAAGATTCTCCTGCCTCAGACCCCGAGTAGCTGGGACTACAGAAATGACATCAGATGTACCATCACTGGGTCCAGCCATTGCCTCTGGAA ACTCTGGACCTGGAATTCAAGGTGGAGGAGCCATTGTCCAGAGGGCTATTAAGCGGCGACCAGGGCTGGATTTTGATGATGATGGAGAAG GGAACAGTAAATTTTTGAGGTGTGATGATGATCAGATGTCTAACGATAAGGAGCGGTTTGCCAGAGACGAGTTGTACTGCTGTCACAGGA AATGGACGCTGGATTACAAGCATGGCAGCTCAGGCAGCAGAAGTTGCAGGAAGAACAAAGGAAGCAGGAAAATGCTCTTAAACCCAAAGG GGCTTCACTGAAGAGCCCACTTCCAAGTCAATAAAAAGCAACTCCTGCCTCCCTTCCTCACCCTGTCTCTGGATTTCTTTTCTATCACCT AGATGCTTCATCCAGCCAGAAGATAGCCTTCACGTTCCCCATCTGTCTTCAGAGAAAAAGAGCTGGGACACCAAGAACAAGCTGTTAGAT CACTGCCTGGGAGGCTTGGCTTAGTACTCTCATCTCTGGTTCCATTCCAGTTCAGCTAAGTCTTGCTTTAAAATTTTTACCTCCTAGCTG GGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACAAGATCAGGAGTTCGAGACCAGCCTGGCCAA >In-frame_ENST00000515192_ENST00000555345_TCGA-KO-8404-01A_ARNT_chr1_150818739_-_MRPL52_chr14_23303381_length(amino acids)=127AA_start in transcript=167_stop in transcript=550 MILDSRFSCLRPRVAGTTEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFLRCDDDQMSNDKERFARDELY -------------------------------------------------------------- >In-frame_ENST00000515192_ENST00000553711_TCGA-KO-8404-01A_ARNT_chr1_150818739_-_MRPL52_chr14_23303381_length(transcript)=598nt_BP=424nt CTTGGATTCCGCGGTAGCGGAGGCGGCGGTCAGGCGCCGCTTCTGGGGAGTGGCCTTTCTTTTCCCCTCCCTCCCGGTTCGGTGGCGGCG GCTCCTCCCACTGGGGGGGGGGGTGGCGCGGCGGCGGTGGCATCTGCGGCCATGGCGGCGACTACTGCCAACCCCGCCTGATCTTGGACT CAAGATTCTCCTGCCTCAGACCCCGAGTAGCTGGGACTACAGAAATGACATCAGATGTACCATCACTGGGTCCAGCCATTGCCTCTGGAA ACTCTGGACCTGGAATTCAAGGTGGAGGAGCCATTGTCCAGAGGGCTATTAAGCGGCGACCAGGGCTGGATTTTGATGATGATGGAGAAG GGAACAGTAAATTTTTGAGGTGTGATGATGATCAGATGTCTAACGATAAGGAGCGGTTTGCCAGAGACGAGTTGTACTGCTGTCACAGGA AATGGACGCTGGATTACAAGCATGGCAGCTCAGGCAGCAGAAGTTGCAGGAAGAACAAAGGAAGCAGGAAAATGCTCTTAAACCCAAAGG >In-frame_ENST00000515192_ENST00000553711_TCGA-KO-8404-01A_ARNT_chr1_150818739_-_MRPL52_chr14_23303381_length(amino acids)=127AA_start in transcript=167_stop in transcript=550 MILDSRFSCLRPRVAGTTEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFLRCDDDQMSNDKERFARDELY -------------------------------------------------------------- >In-frame_ENST00000515192_ENST00000397505_TCGA-KO-8404-01A_ARNT_chr1_150818739_-_MRPL52_chr14_23303381_length(transcript)=600nt_BP=424nt CTTGGATTCCGCGGTAGCGGAGGCGGCGGTCAGGCGCCGCTTCTGGGGAGTGGCCTTTCTTTTCCCCTCCCTCCCGGTTCGGTGGCGGCG GCTCCTCCCACTGGGGGGGGGGGTGGCGCGGCGGCGGTGGCATCTGCGGCCATGGCGGCGACTACTGCCAACCCCGCCTGATCTTGGACT CAAGATTCTCCTGCCTCAGACCCCGAGTAGCTGGGACTACAGAAATGACATCAGATGTACCATCACTGGGTCCAGCCATTGCCTCTGGAA ACTCTGGACCTGGAATTCAAGGTGGAGGAGCCATTGTCCAGAGGGCTATTAAGCGGCGACCAGGGCTGGATTTTGATGATGATGGAGAAG GGAACAGTAAATTTTTGAGGTGTGATGATGATCAGATGTCTAACGATAAGGAGCGGTTTGCCAGAGACGAGTTGTACTGCTGTCACAGGA AATGGACGCTGGATTACAAGCATGGCAGCTCAGGCAGCAGAAGTTGCAGGAAGAACAAAGGAAGCAGGAAAATGCTCTTAAACCCAAAGG >In-frame_ENST00000515192_ENST00000397505_TCGA-KO-8404-01A_ARNT_chr1_150818739_-_MRPL52_chr14_23303381_length(amino acids)=127AA_start in transcript=167_stop in transcript=550 MILDSRFSCLRPRVAGTTEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFLRCDDDQMSNDKERFARDELY -------------------------------------------------------------- >In-frame_ENST00000515192_ENST00000557221_TCGA-KO-8404-01A_ARNT_chr1_150818739_-_MRPL52_chr14_23303381_length(transcript)=1081nt_BP=424nt CTTGGATTCCGCGGTAGCGGAGGCGGCGGTCAGGCGCCGCTTCTGGGGAGTGGCCTTTCTTTTCCCCTCCCTCCCGGTTCGGTGGCGGCG GCTCCTCCCACTGGGGGGGGGGGTGGCGCGGCGGCGGTGGCATCTGCGGCCATGGCGGCGACTACTGCCAACCCCGCCTGATCTTGGACT CAAGATTCTCCTGCCTCAGACCCCGAGTAGCTGGGACTACAGAAATGACATCAGATGTACCATCACTGGGTCCAGCCATTGCCTCTGGAA ACTCTGGACCTGGAATTCAAGGTGGAGGAGCCATTGTCCAGAGGGCTATTAAGCGGCGACCAGGGCTGGATTTTGATGATGATGGAGAAG GGAACAGTAAATTTTTGAGGTGTGATGATGATCAGATGTCTAACGATAAGGAGCGGTTTGCCAGAGACGAGTTGTACTGCTGTCACAGGA AATGGACGCTGGATTACAAGCATGGCAGCTCAGGCAGCAGAAGTTGCAGGAAGAACAAAGGAAGCAGGAAAATGCTCTTAAACCCAAAGG GGCTTCACTGAAGAGCCCACTTCCAAGTCAATAAAAAGCAACTCCTGCCTCCCTTCCTCACCCTGTCTCTGGATTTCTTTTCTATCACCT AGATGCTTCATCCAGCCAGAAGATAGCCTTCACGTTCCCCATCTGTCTTCAGAGAAAAAGAGCTGGGACACCAAGAACAAGCTGTTAGAT CACTGCCTGGGAGGCTTGGCTTAGTACTCTCATCTCTGGTTCCATTCCAGTTCAGCTAAGTCTTGCTTTAAAATTTTTACCTCCTAGCTG GGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACAAGATCAGGAGTTCGAGACCAGCCTGGCCAA CCCAGCCTGGTCAACATGGTGAAACCCTGTCCCTACTAAAGATACAAACAATTAGCCGGGCGTGGTGGGGTGCGCTTGTAATCCCAGCTA CTCAGGAGGCTGAGGCAGGAGAATCGCTTAAACTCGGGAGGTAGAGGTTGCAGTGAGCCAAGGTCACACCATTGCACTCCAACCTGGGCG >In-frame_ENST00000515192_ENST00000557221_TCGA-KO-8404-01A_ARNT_chr1_150818739_-_MRPL52_chr14_23303381_length(amino acids)=127AA_start in transcript=167_stop in transcript=550 MILDSRFSCLRPRVAGTTEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFLRCDDDQMSNDKERFARDELY -------------------------------------------------------------- >In-frame_ENST00000505755_ENST00000311892_TCGA-KO-8404-01A_ARNT_chr1_150818739_-_MRPL52_chr14_23303381_length(transcript)=1075nt_BP=269nt ACTGGGGGGGGGGGTGGCGCGGCGGCGGTGGCATCTGCGGCCATGGCGGCGACTACTGCCAACCCCGAAATGACATCAGATGTACCATCA CTGGGTCCAGCCATTGCCTCTGGAAACTCTGGACCTGGAATTCAAGGTGGAGGAGCCATTGTCCAGAGGGCTATTAAGCGGCGACCAGGG CTGGATTTTGATGATGATGGAGAAGGGAACAGTAAATTTTTGAGGTGTGATGATGATCAGATGTCTAACGATAAGGAGCGGTTTGCCAGA GACGAGTTGTACTGCTGTCACAGGAAATGGACGCTGGATTACAAGCATGGCAGCTCAGGCAGCAGAAGTTGCAGGAAGAACAAAGGAAGC AGGAAAATGCTCTTAAACCCAAAGGGGCTTCACTGAAGAGCCCACTTCCAAGTCAATAAAAAGCAACTCCTGCCTCCCTTCCTCACCCTG TCTCTGGATTTCTTTTCTATCACCTAGATGCTTCATCCAGCCAGAAGATAGCCTTCACGTTCCCCATCTGTCTTCAGAGAAAAAGAGCTG GGACACCAAGAACAAGCTGTTAGATCACTGCCTGGGAGGCTTGGCTTAGTACTCTCATCTCTGGTTCCATTCCAGTTCAGCTAAGTCTTG CTTTAAAATTTTTACCTCCTAGCTGGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACAAGATC AGGAGTTCGAGACCAGCCTGGCCAACCCAGCCTGGTCAACATGGTGAAACCCTGTCCCTACTAAAGATACAAACAATTAGCCGGGCGTGG TGGGGTGCGCTTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTAAACTCGGGAGGTAGAGGTTGCAGTGAGCCAAGGTC ACACCATTGCACTCCAACCTGGGCGACAGGGCGAGACTCCGTCTCAAAAAAAAAAAAAAATTTACCTCCTTTGCAGGCCATAGGACTAGC >In-frame_ENST00000505755_ENST00000311892_TCGA-KO-8404-01A_ARNT_chr1_150818739_-_MRPL52_chr14_23303381_length(amino acids)=117AA_start in transcript=42_stop in transcript=395 MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFLRCDDDQMSNDKERFARDELYCCHRKWTLDY -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ARNT-MRPL52 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ARNT-MRPL52 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ARNT-MRPL52 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ARNT | C0000786 | Spontaneous abortion | 1 | CTD_human |
Hgene | ARNT | C0000822 | Abortion, Tubal | 1 | CTD_human |
Hgene | ARNT | C0009402 | Colorectal Carcinoma | 1 | CTD_human |
Hgene | ARNT | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Hgene | ARNT | C0014175 | Endometriosis | 1 | CTD_human |
Hgene | ARNT | C0019193 | Hepatitis, Toxic | 1 | CTD_human |
Hgene | ARNT | C0023452 | Childhood Acute Lymphoblastic Leukemia | 1 | CTD_human |
Hgene | ARNT | C0023453 | L2 Acute Lymphoblastic Leukemia | 1 | CTD_human |
Hgene | ARNT | C0023890 | Liver Cirrhosis | 1 | CTD_human |
Hgene | ARNT | C0025202 | melanoma | 1 | CTD_human |
Hgene | ARNT | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
Hgene | ARNT | C0239946 | Fibrosis, Liver | 1 | CTD_human |
Hgene | ARNT | C0269102 | Endometrioma | 1 | CTD_human |
Hgene | ARNT | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human |
Hgene | ARNT | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human |
Hgene | ARNT | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
Hgene | ARNT | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human |
Hgene | ARNT | C3830362 | Early Pregnancy Loss | 1 | CTD_human |
Hgene | ARNT | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Hgene | ARNT | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |
Hgene | ARNT | C4552766 | Miscarriage | 1 | CTD_human |