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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PRKCA-SDK1 (FusionGDB2 ID:68298)

Fusion Gene Summary for PRKCA-SDK1

check button Fusion gene summary
Fusion gene informationFusion gene name: PRKCA-SDK1
Fusion gene ID: 68298
HgeneTgene
Gene symbol

PRKCA

SDK1

Gene ID

5578

221935

Gene nameprotein kinase C alphasidekick cell adhesion molecule 1
SynonymsAAG6|PKC-alpha|PKCA|PKCI+/-|PKCalpha|PRKACA-
Cytomap

17q24.2

7p22.2

Type of geneprotein-codingprotein-coding
Descriptionprotein kinase C alpha typePKC-Aaging-associated gene 6protein sidekick-1sidekick homolog 1, cell adhesion molecule
Modification date2020032720200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000413366, ENST00000583361, 
ENST00000404826, ENST00000389531, 
ENST00000466611, 
Fusion gene scores* DoF score44 X 23 X 14=1416821 X 21 X 9=3969
# samples 4623
** MAII scorelog2(46/14168*10)=-4.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/3969*10)=-4.10906979605546
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRKCA [Title/Abstract] AND SDK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPRKCA(64641629)-SDK1(3990555), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRKCA

GO:0006468

protein phosphorylation

10770950

HgenePRKCA

GO:0035408

histone H3-T6 phosphorylation

20228790

HgenePRKCA

GO:0043536

positive regulation of blood vessel endothelial cell migration

20011604

HgenePRKCA

GO:0090330

regulation of platelet aggregation

12724315


check buttonFusion gene breakpoints across PRKCA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SDK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-66-2793-01APRKCAchr17

64641629

-SDK1chr7

3990555

+


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Fusion Gene ORF analysis for PRKCA-SDK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000413366ENST00000404826PRKCAchr17

64641629

-SDK1chr7

3990555

+
In-frameENST00000413366ENST00000389531PRKCAchr17

64641629

-SDK1chr7

3990555

+
5CDS-intronENST00000413366ENST00000466611PRKCAchr17

64641629

-SDK1chr7

3990555

+
intron-3CDSENST00000583361ENST00000404826PRKCAchr17

64641629

-SDK1chr7

3990555

+
intron-3CDSENST00000583361ENST00000389531PRKCAchr17

64641629

-SDK1chr7

3990555

+
intron-intronENST00000583361ENST00000466611PRKCAchr17

64641629

-SDK1chr7

3990555

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000413366PRKCAchr1764641629-ENST00000404826SDK1chr73990555+99665551463492111
ENST00000413366PRKCAchr1764641629-ENST00000389531SDK1chr73990555+73145551462892091

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000413366ENST00000404826PRKCAchr1764641629-SDK1chr73990555+0.0006573430.9993426
ENST00000413366ENST00000389531PRKCAchr1764641629-SDK1chr73990555+0.0014497360.99855024

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Fusion Genomic Features for PRKCA-SDK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PRKCA-SDK1


check button Go to

FGviewer for the breakpoints of chr17:64641629-chr7:3990555

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRKCAchr17:64641629chr7:3990555ENST00000413366-517101_151176.33333333333334673.0Zinc fingerPhorbol-ester/DAG-type 2
HgenePRKCAchr17:64641629chr7:3990555ENST00000413366-51736_86176.33333333333334673.0Zinc fingerPhorbol-ester/DAG-type 1
TgeneSDK1chr17:64641629chr7:3990555ENST000004048264451072_1171282.33333333333332214.0DomainFibronectin type-III 5
TgeneSDK1chr17:64641629chr7:3990555ENST000004048264451176_1274282.33333333333332214.0DomainFibronectin type-III 6
TgeneSDK1chr17:64641629chr7:3990555ENST000004048264451279_1376282.33333333333332214.0DomainFibronectin type-III 7
TgeneSDK1chr17:64641629chr7:3990555ENST000004048264451380_1474282.33333333333332214.0DomainFibronectin type-III 8
TgeneSDK1chr17:64641629chr7:3990555ENST000004048264451479_1576282.33333333333332214.0DomainFibronectin type-III 9
TgeneSDK1chr17:64641629chr7:3990555ENST000004048264451581_1699282.33333333333332214.0DomainFibronectin type-III 10
TgeneSDK1chr17:64641629chr7:3990555ENST000004048264451704_1800282.33333333333332214.0DomainFibronectin type-III 11
TgeneSDK1chr17:64641629chr7:3990555ENST000004048264451804_1899282.33333333333332214.0DomainFibronectin type-III 12
TgeneSDK1chr17:64641629chr7:3990555ENST000004048264451902_2000282.33333333333332214.0DomainFibronectin type-III 13
TgeneSDK1chr17:64641629chr7:3990555ENST00000404826445293_378282.33333333333332214.0DomainNote=Ig-like C2-type 3
TgeneSDK1chr17:64641629chr7:3990555ENST00000404826445386_476282.33333333333332214.0DomainNote=Ig-like C2-type 4
TgeneSDK1chr17:64641629chr7:3990555ENST00000404826445480_569282.33333333333332214.0DomainNote=Ig-like C2-type 5
TgeneSDK1chr17:64641629chr7:3990555ENST00000404826445574_663282.33333333333332214.0DomainNote=Ig-like C2-type 6
TgeneSDK1chr17:64641629chr7:3990555ENST00000404826445670_766282.33333333333332214.0DomainFibronectin type-III 1
TgeneSDK1chr17:64641629chr7:3990555ENST00000404826445771_867282.33333333333332214.0DomainFibronectin type-III 2
TgeneSDK1chr17:64641629chr7:3990555ENST00000404826445872_970282.33333333333332214.0DomainFibronectin type-III 3
TgeneSDK1chr17:64641629chr7:3990555ENST00000404826445974_1068282.33333333333332214.0DomainFibronectin type-III 4
TgeneSDK1chr17:64641629chr7:3990555ENST000004048264452207_2213282.33333333333332214.0MotifPDZ-binding
TgeneSDK1chr17:64641629chr7:3990555ENST000004048264452031_2213282.33333333333332214.0Topological domainCytoplasmic
TgeneSDK1chr17:64641629chr7:3990555ENST000004048264452010_2030282.33333333333332214.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRKCAchr17:64641629chr7:3990555ENST00000413366-517158_275176.33333333333334673.0DomainC2
HgenePRKCAchr17:64641629chr7:3990555ENST00000413366-517339_597176.33333333333334673.0DomainProtein kinase
HgenePRKCAchr17:64641629chr7:3990555ENST00000413366-517598_668176.33333333333334673.0DomainAGC-kinase C-terminal
HgenePRKCAchr17:64641629chr7:3990555ENST00000413366-517345_353176.33333333333334673.0Nucleotide bindingATP
TgeneSDK1chr17:64641629chr7:3990555ENST0000040482644519_58282.33333333333332214.0Compositional biasNote=Pro-rich
TgeneSDK1chr17:64641629chr7:3990555ENST00000404826445104_186282.33333333333332214.0DomainNote=Ig-like C2-type 1
TgeneSDK1chr17:64641629chr7:3990555ENST00000404826445191_277282.33333333333332214.0DomainNote=Ig-like C2-type 2


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Fusion Gene Sequence for PRKCA-SDK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000413366_ENST00000404826_TCGA-66-2793-01A_PRKCA_chr17_64641629_-_SDK1_chr7_3990555_length(transcript)=9966nt_BP=555nt
GAGGCAAGAGGTGGTTGGGGGGGACCATGGCTGACGTTTTCCCGGGCAACGACTCCACGGCGTCTCAGGACGTGGCCAACCGCTTCGCCC
GCAAAGGGGCGCTGAGGCAGAAGAACGTGCACGAGGTGAAGGACCACAAATTCATCGCGCGCTTCTTCAAGCAGCCCACCTTCTGCAGCC
ACTGCACCGACTTCATCTGGGGGTTTGGGAAACAAGGCTTCCAGTGCCAAGTTTGCTGTTTTGTGGTCCACAAGAGGTGCCATGAATTTG
TTACTTTTTCTTGTCCGGGTGCGGATAAGGGACCCGACACTGATGACCCCAGGAGCAAGCACAAGTTCAAAATCCACACTTACGGAAGCC
CCACCTTCTGCGATCACTGTGGGTCACTGCTCTATGGACTTATCCATCAAGGGATGAAATGTGACACCTGCGATATGAACGTTCACAAGC
AATGCGTCATCAATGTCCCCAGCCTCTGCGGAATGGATCACACTGAGAAGAGGGGGCGGATTTACCTAAAGGCTGAGGTTGCTGATGAAA
AGCTCCATGTCACAGGAGATGTTGGCACACCTGAAACCATGGCCCCAACCATTGTGGTTCCCCCGGGCAACAGAAGTGTGGTGGCTGGAT
CCAGTGAGACCACCTTGGAATGTATAGCCAGTGCCAGGCCTGTGGAGGACCTGAGTGTGACCTGGAAGAGGAATGGAGTGAGAATCACCA
GTGGCCTCCACAGCTTTGGAAGACGCCTCACCATCAGCAACCCGACGTCCGCGGACACCGGGCCATACGTCTGCGAGGCGGCGCTGCCGG
GGAGCGCTTTTGAACCGGCCAGGGCGACGGCCTTTCTTTTCATCATAGAGCCACCATATTTTACTGCTGAGCCCGAGAGTCGGATTTCAG
CTGAAGTAGAAGAAACTGTGGACATCGGATGTCAAGCCATGGGGGTCCCCCTTCCCACCCTCCAGTGGTACAAGGATGCCATCTCCATCA
GCAGGCTCCAGAATCCTCGATACAAAGTGCTCGCCAGCGGAGGCCTGCGCATCCAGAAGCTGCGTCCAGAGGACTCCGGAATCTTCCAGT
GCTTCGCCAGCAATGAAGGAGGGGAGATCCAGACCCACACCTACCTGGATGTAACCAATATCGCTCCAGTGTTCACCCAGCGGCCAGTGG
ACACCACAGTTACTGACGGGATGACAGCCATTCTAAGGTGTGAGGTGTCCGGGGCTCCCAAACCCGCCATCACCTGGAAAAGAGAAAACC
ACATTCTGGCCAGTGGCTCTGTCCGGATTCCTAGGTTCATGCTTCTTGAATCGGGGGGTCTACAGATCGCGCCCGTCTTCATCCAGGATG
CCGGCAACTACACCTGCTATGCGGCCAACACAGAGGGCTCCCTGAATGCATCGGCCACGCTCACTGTGTGGAATCGGACGTCCATCGTCC
ACCCTCCTGAGGACCACGTGGTGATTAAGGGGACCACGGCCACGCTGCACTGTGGTGCCACACATGACCCCCGGGTTTCACTCCGCTACG
TTTGGAAGAAGGACAACGTGGCCCTGACTCCATCGAGCACGTCTAGGATCGTGGTGGAGAAGGACGGGTCCCTTCTCATCAGCCAGACGT
GGTCAGGCGACATCGGTGACTACAGCTGCGAGATTGTTTCTGAAGGAGGGAATGACTCCAGGATGGCCCGGCTGGAAGTGATTGAACTGC
CTCATTCACCTCAGAACCTCCTGGTCAGCCCTAATTCTTCCCACAGCCACGCCGTGGTGCTCTCTTGGGTCCGGCCCTTTGATGGAAACA
GTCCTATTCTTTATTACATCGTGGAGCTCTCTGAAAACAACTCTCCATGGAAGGTGCATCTGTCAAACGTTGGCCCTGAGATGACAGGCG
TCACCGTGAGTGGCCTGACTCCGGCTCGTACCTATCAATTCCGGGTGTGCGCGGTGAATGAAGTGGGCAGGGGCCAGTACAGCGCCGAGA
CAAGCAGGTTGATGCTACCTGAAGAACCACCCAGTGCTCCCCCGAAAAATATAGTGGCCAGTGGGCGGACTAATCAGTCCATTATGGTCC
AGTGGCAGCCACCCCCAGAAACAGAGCACAACGGGGTGTTGCGTGGATACATCCTCAGGTACCGCCTGGCTGGCCTTCCCGGAGAGTACC
AGCAGCGGAACATCACCAGCCCGGAGGTGAACTACTGCCTGGTGACAGACCTGATCATCTGGACACAGTATGAGATACAGGTGGCGGCGT
ACAACGGGGCCGGTCTGGGCGTCTTCAGCAGGGCAGTGACCGAGTACACCTTGCAGGGAGTGCCCACCGCGCCCCCGCAGAACGTGCAGA
CGGAAGCCGTGAACTCCACCACCATTCAGTTCCTGTGGAACCCTCCGCCTCAGCAGTTTATCAATGGCATCAACCAGGGATACAAGCTTC
TGGCATGGCCGGCAGATGCCCCCGAGGCTGTCACTGTGGTCACTATTGCCCCAGATTTCCACGGAGTCCACCATGGACACATAACGAACC
TGAAGAAGTTTACCGCCTACTTCACTTCCGTTCTGTGCTTCACCACCCCTGGGGACGGGCCTCCCAGCACACCTCAGCTGGTCTGGACTC
AGGAAGACAAACCAGGAGCTGTGGGACATCTGAGTTTCACAGAGATCTTGGACACATCTCTCAAGGTCAGCTGGCAGGAGCCCCTGGAGA
AAAATGGCATCATTACTGGCTATCAGATCTCTTGGGAAGTGTACGGCAGGAACGACTCTCGTCTCACGCACACCCTGAACAGCACGACGC
ACGAGTACAAGATCCAAGGCCTCTCATCTCTCACCACCTACACCATCGACGTGGCCGCTGTGACTGCCGTGGGCACTGGCCTGGTGACTT
CATCCACCATTTCTTCTGGAGTGCCCCCAGACCTTCCTGGTGCCCCATCCAACCTGGTCATTTCCAACATCAGCCCTCGCTCCGCCACCC
TTCAGTTCCGGCCAGGCTATGACGGGAAAACGTCCATCTCCAGGTGGATTGTTGAGGGGCAGGTGGGAGCTATCGGCGACGAGGAGGAGT
GGGTCACCCTCTATGAAGAGGAGAATGAGCCTGATGCCCAGATGCTGGAGATCCCAAACCTCACACCCTACACTCACTACAGATTTCGAA
TGAAGCAAGTGAACATTGTTGGGCCGAGCCCCTACAGTCCGTCTTCCCGGGTCATCCAGACCCTGCAGGCCCCACCCGACGTGGCTCCAA
CCAGCGTCACGGTCCGTACTGCCAGTGAGACCAGCCTGCGGCTTCGCTGGGTGCCCCTGCCGGATTCTCAGTACAACGGGAACCCCGAGT
CCGTGGGCTACAGGATTAAGTACTGGCGCTCAGACCTCCAGTCCTCAGCAGTGGCCCAAGTCGTCAGTGACCGGCTGGAGAGAGAATTCA
CCATCGAGGAGCTGGAGGAGTGGATGGAATACGAGCTGCAGATGCAGGCCTTCAACGCCGTCGGGGCTGGGCCGTGGAGCGAGGTGGTGC
GGGGCCGGACGCGGGAGTCAGTTCCTTCAGCCGCCCCTGAGAACGTGTCAGCCGAGGCTGTCAGCTCGACCCAGATTTTACTGACATGGA
CATCCGTGCCGGAACAGGACCAGAATGGGCTCATACTGGGCTACAAGATCCTGTTCCGGGCCAAAGACCTGGATCCCGAGCCCAGGAGCC
ACATCGTGCGAGGGAACCACACGCAGTCGGCCCTGCTGGCAGGCCTGCGCAAGTTCGTGCTCTACGAGCTCCAGGTGCTGGCGTTCACCC
GCATCGGGAACGGGGTCCCCAGCACGCCCCTCATCCTGGAGCGCACCAAAGACGATGCCCCAGGCCCACCAGTGAGGCTCGTGTTCCCCG
AAGTGAGACTCACCTCCGTGCGGATAGTGTGGCAACCTCCGGAGGAGCCCAACGGCATCATCCTGGGGTACCAGATTGCCTACCGCCTGG
CCAGCAGCAGCCCCCACACCTTCACCACCGTGGAGGTCGGCGCCACAGTGAGGCAGTTCACAGCCACCGACCTGGCCCCGGAGTCCGCAT
ACATCTTCAGGCTGTCCGCCAAGACGAGGCAGGGCTGGGGGGAGCCACTGGAGGCCACCGTCATCACCACCGAGAAGAGAGAGCGGCCGG
CACCCCCCAGAGAGCTCCTGGTGCCCCAGGCAGAAGTGACCGCACGCAGCCTCCGGCTCCAGTGGGTCCCGGGCAGCGACGGGGCCTCCC
CCATCCGGTACTTCACCATGCAGGTGCGAGAGCTGCCTCGGGGTGAGTGGCAGACCTACTCCTCGTCCATCAGCCATGAGGCGACAGCAT
GCGTCGTTGACAGACTGAGGCCCTTCACCTCCTACAAGCTGCGCCTGAAAGCCACCAACGACATTGGGGACAGTGACTTCAGTTCAGAGA
CAGAGGCGGTGACCACGCTGCAGGATGTTCCAGGAGAGCCCCCGGGATCTGTCTCAGCGACGCCACACACCACGTCCTCTGTCCTGATAC
AGTGGCAGCCTCCGAGGGACGAAAGCCTGAATGGCCTTCTTCAGGGATACAGGATCTACTACAGGGAGCTGGAGTATGAAGCCGGGTCAG
GCACTGAGGCCAAGACGCTCAAAAACCCTATAGCTTTACATGCTGAGCTCACAGCCCAAAGCAGCTTCAAGACGGTGAACAGCAGCTCCA
CATCGACGATGTGTGAACTAACACATTTAAAGAAGTACCGGCGCTATGAAGTAATAATGACCGCCTATAACATCATCGGCGAGAGCCCAG
CCAGCGCGCCCGTGGAGGTCTTTGTCGGCGAGGCTGCCCCGGCCATGGCCCCGCAGAACGTGCAGGTGACCCCACTCACGGCCAGCCAGC
TGGAGGTCACGTGGGACCCACCACCCCCGGAGAGCCAGAATGGGAACATCCAAGGCTACAAGATTTACTACTGGGAGGCAGACAGCCAGA
ACGAAACGGAGAAAATGAAGGTCCTCTTCCTCCCCGAGCCCGTGGTGAGGCTGAAGAACCTGACCAGCCATACCAAGTACCTGGTCAGCA
TATCAGCCTTCAACGCCGCCGGAGATGGACCTAAGAGTGACCCCCAGCAGGGGCGCACCCACCAGGCCGCCCCTGGGGCCCCCAGCTTTC
TGGCGTTCTCAGAAATAACCTCCACCACGCTCAACGTGTCCTGGGGCGAGCCTGCGGCGGCCAACGGCATCCTGCAGGGCTATCGGGTGG
TGTACGAGCCCTTGGCCCCTGTACAAGGGGTGAGCAAGGTGGTGACCGTGGAAGTGAGAGGGAACTGGCAGCGCTGGCTGAAGGTGCGGG
ACCTCACCAAGGGAGTGACCTATTTCTTCCGTGTCCAAGCGCGGACCATCACCTACGGGCCCGAGCTCCAAGCCAATATCACAGCCGGGC
CAGCCGAGGGATCCCCGGGCTCGCCTAGAGATGTCCTGGTCACCAAGTCCGCCTCTGAACTGACGCTGCAGTGGACTGAGGGACACTCTG
GCGACACACCTACCACGGGCTATGTGATCGAGGCCCGGCCCTCAGATGAAGGCTTATGGGACATGTTTGTGAAGGACATCCCGCGGAGCG
CCACATCCTACACCCTCAGCCTGGATAAGCTCCGGCAAGGAGTGACTTACGAGTTCCGGGTGGTGGCTGTGAATGAGGCGGGCTACGGGG
AGCCCAGCAACCCCTCCACGGCTGTGTCAGCTCAAGTGGAAGCCCCATTCTACGAGGAGTGGTGGTTCCTCCTGGTGATGGCTCTGTCCA
GCCTGATCGTCATCCTGCTGGTGGTGTTCGCCCTCGTCCTGCACGGGCAGAATAAGAAGTATAAGAACTGCAGCACAGGAAAGGGGATCT
CCACCATGGAGGAGTCTGTGACCCTGGACAACGGAGGATTTGCTGCCCTGGAGCTCAGCAGCCGCCACCTCAATGTCAAGAGCACCTTCT
CCAAGAAGAACGGGACCAGGTCCCCACCCCGGCCTAGCCCCGGCGGCCTGCACTACTCAGACGAGGACATCTGCAACAAGTACAACGGCG
CCGTGCTGACCGAGAGCGTGAGCCTCAAGGAGAAGTCGGCAGATGCATCAGAATCTGAGGCCACGGACTCTGACTACGAGGACGCGCTGC
CCAAGCACTCCTTCGTGAACCACTACATGAGCGACCCCACCTACTACAACTCATGGAAGCGCAGGGCCCAGGGCCGCGCACCTGCGCCGC
ACAGGTACGAGGCGGTGGCGGGCTCCGAGGCGGGCGCGCAGCTGCACCCGGTCATCACCACGCAGAGCGCGGGCGGCGTCTACACCCCCG
CTGGCCCCGGCGCGCGAACTCCGCTCACCGGCTTCTCCTCCTTCGTGTGAGCAAAGCGCCGCGCCTCCCTCAGGGCGGAACGGAGGCAAC
TTTCCGGAGTCTATTTTTGTTAAGACAATCAACTCCAATAACTGAGCTGAAGTTTTTGTTTAAAAAGAAAAAAATCTGATAAGTGATGAT
TTTACCTACTTGTGGACACTAGATTTCAATTAGGAAGGTTTTTTTAAACGGCTTTTTGTAACTTCGCTGCAGGAAGCAGGTTTGTTTCTT
TTTCTTTTCTTTTTAAGAGAAGGTGTATTTCACTGGTGCAATGGCTTGGCACCTCCGGGGCCTGGGAGGACCTCAGACCTCCCCAGCCCT
GGGTTTCTCCGTCTTCAAGACCAACTAGGAAGGGTCAAGCGGGGAGAGGGAGTGGAGGGTCAGGTGAGATCTCAGAGCTGCCCCGGCCGG
CCCCCGTCTCTTTCTACCTCCTCTTCCAGAGAACCAGCGGCTCACACCCTTCTCAACGCAGGACATCCTCGGCGGCTCCTGGGGTTTGAA
GAGCAAACGTTTTTCCCTGGGCTCAGTGCGTTTTGTCCCAACTTCATCTGTTTCTGAAATGTTCTCACTTGGCAGTGTCTAGTCAAGGAG
TCGGCTTTCAGGTTCCTGACGGCCAGGCAGGGATGCTAAGGTGTGGCTCAGCCGTCACTGTCTGTGTCACTGCAGTGGTGCGGTCCTCAG
GCTTTTCTGCCTGTCTTTCCCCCTTCCTTCTCACCTGACAGCGAGGGAGAGGGAAGCCTCTTAGGGCTGGAAGCCACCACGCTGGCCCTC
TCCTTCCCCGAACACAGCACACGGTCAACTCCGCGGGACACGAGGACACGGGACGGCGTCTCCAGAATTGCTTGTTACGTAGGAAGCGTG
CATTGTTAACCAGAGTATTTTTAAAATCTTTTTATCTTTTTTTAAACTATGTCACATGAAATGAATGCGTCTTTGCTGTCTCCAGGTGCC
TTTTTATTAATTGTTCAGCTTTGTACATGGGAAAGATGAAAAGCAACAGTGTCTGCAAATAAAGCAAAACAGCTCTGAGAACACACGCTC
CCGACTCGCCTCGTGCACACCAGGCCGTCCCCTCCCTCTGTCCTGGCTTCTGCTGGCTGCTCGCAGCAGCCACCGCTTCTCCACCACTGG
CGCTGCTGCTGCCCCCTCTCCCAGTCCGAGGCCAGCTTTTAGCCTTAACAGGTTTTTTGGAAATGTTTCTTTTTTTTATTTAAAATTGTC
ATTGTTTGGTTTAAATTTTTCAGCTAGATGAAAAGAGTATGAACTACTTTGGAAAACTTAACAGCTCAGAGATGGCCATGCCTCCAGCCC
CTCACGTCATCTTTGCAACAGACGACTGGGCTGCCATGGTCCACCCCTCAGCCCGGGTCCCGGGTCTGGATGGAACGGGAGCACTGCTGG
TGCCCACTGGCGTGTGTGCCCCGGGTCCCTGTAAGTGCCCCCTCACCAGCAGCAGCGTGACACACACAAGACTCAAGACCACCCTGTCAG
TGCCCCCCAGTGCACGGCAAACGGGCAGGTGCCGTTCCCCCAGTGACCTGAGGGTAGGGGACAACTGAGCAGTATCTGACCAGTGCCACC
CAGGAGCCAGTCTCCTGGCCACATGCAGAAAGTGTGGCCCCTGCTTACCTAGATGTTTTGTGCACCTCCATGGGCAGAGGGTGTGGATAT
TGCCTGGATTCTGTGCTGTCAGCGTTGCTGAGTATGGCCCCAGGAGACCAAGGAGAGTTTTGTATAGGCTGGAAAACCCCTTTTCAGTCT
TTCCAAAATTAGAGGGTATGGCAAGTTTCCTTTTTTCTCTCCTCCCTTCCTTCCCCTCCTTCCTTTCCTTTACCCCTCCTTTCCTTCCTT
CCTCCCTTCCTCTCTTCTTTCCTCCCTCCCTCCCTCCTTCCCTCCCTTCCTTCCTCTCTTTCCTCCTTCCTTCCCTCCCTTCTTTCCCTC
CCTCCCTTCCTCTCTCCCCTATTCCTTCTTCCTTTTCTCCTCCTTTTTCTGAGTGGAGGGGGAAATATTCTAAACCAAAAATCCTAGATG
CTCTGCCCAAAGCCACTTCTGCATGAGAATCGCAACCCACAGTTCCCCGGATGAGACTCACCACAGTGGACAGTGCCACCTCCTTCCCCT
CGGCCCCGGAGAGGGCGAAGTGGGCGGGAAGCCAGGATGTGAGCACTGGAATTTCTTGGAAGAGAAGCGATAAATGGAGACCATGGCCAG
CGCTGCTTTCTGTGCACTCTGATGACTGCTCTCTGCAGCCATGAGGATGTGGCTTTACATGCCAGGGAGAGTGTTGAGACGTCTTAGGTT
GAGGATGAGCAGATTCGAGATATGTTTGTTGCTCTCGGGTTTTCGATACAACATCATGACACTTCTGTTTCAAGCTCATGTTTTCCGTCT
CCCCTCCACTCTTAGTAAACCTTGATCTGTACGGAGCGGCCTGTCCGAGGCTACGCCGGCCTCCTGGCTGCTGCTGGACTGTGCTTAGGA
CAGCGCCCATGCCTCGGAGGGACTCTGTCCCATGAGAACCACCTGTGCAAAGGAACAGAGCTGGATGTTTCCAGGTAGATTTTGGCCTCC
CAGAGCAATGCGGCATTTGAGAAGCAACAGTTCCTAACTCCTTATCTTCAGGGAAGGAAAAGAAAATCACAGCCTAGGAAGATGGAGGTT
GGATTTTAATCTCGGTTTTAAAAAGAGGACAAACAAAATGTCTCTAAGCCAGGCTAGATGGAATGTGCTCCCGCTCTCTCCTGCCGTGCT
GAAAGTCATGCCTTGCGGATGCCTCATGACAGCAGTGGCTGAGTCTCCCCACCCACCCCCAACGTGGCTCATTTCAGATTGCTTCGGCCC
CACCCTGCAAGGATGTGGTCACGGAGTGGCCAGGAGGCTCCGTCTGAGCCACAGGGATGGGTGTGCAGAGCTCCCTCCTCCTGGGGTGCC
AGGGCAGAGATTCCAGGCAGGTGAGCCCAGAGAGAGCTGCCAGGCCACACCCCCTCGGCCTCCTGCACGGCCACCTTCTGGGTGAATCGG
TCCAGCCCAAGCCCCTCTCCCCAGCCTCGCCTTCAGCCTCTCTCCCAGCCTGCTTTTATAAGGCGCACTTCACTCAATGCTGTAGCCAAA
AAACGAGGGGCCCCAGGGAGAGGGGACCCAGATGGCCACACACGGAACGCGCCTCCACAGCCCCGGGAGGTGGCTCACTCTGTACAGGTC
TTCGGAGGCCGTGTTTGTATCTAACTGTGACTGGGCTGAAGCATGATGTTTGCCTAATGGTTCGTAGCATGGTTTTTATTTCTTACGCAT
TCTTGGCACACAGTGTAGCTATCCTCCTGACGAGCAACCCGTCTGCGTACCTAAGTGTGGCTCCCCGTGGGTCAGCGTCCTGGTAGCATG
GATCCAGTCTGAAAGGTGAGGACAACGTGGAAACTCATGAGCTGAGCCTGCCCGCTGGGACACGTCTCCTTCCCGCGTCACCTTCTGGTT
TAGGGAGCCGTCAGGTCCCTAAACGTTCCCTACAACTTTTTCTGAAATTGTGCAGAAAAACAGATCTCATTAAAAGAAAAAAAGAAACAA

>In-frame_ENST00000413366_ENST00000404826_TCGA-66-2793-01A_PRKCA_chr17_64641629_-_SDK1_chr7_3990555_length(amino acids)=2111AA_start in transcript=14_stop in transcript=6349
MGGTMADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC
PGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVT
GDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHSFGRRLTISNPTSADTGPYVCEAALPGSAFE
PARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASN
EGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYT
CYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDI
GDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSG
LTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNI
TSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPA
DAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGII
TGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRP
GYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTV
RTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTR
ESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNG
VPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRL
SAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDR
LRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAK
TLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTW
DPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSE
ITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGS
PGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNP
STAVSAQVEAPFYEEWWFLLVMALSSLIVILLVVFALVLHGQNKKYKNCSTGKGISTMEESVTLDNGGFAALELSSRHLNVKSTFSKKNG
TRSPPRPSPGGLHYSDEDICNKYNGAVLTESVSLKEKSADASESEATDSDYEDALPKHSFVNHYMSDPTYYNSWKRRAQGRAPAPHRYEA

--------------------------------------------------------------
>In-frame_ENST00000413366_ENST00000389531_TCGA-66-2793-01A_PRKCA_chr17_64641629_-_SDK1_chr7_3990555_length(transcript)=7314nt_BP=555nt
GAGGCAAGAGGTGGTTGGGGGGGACCATGGCTGACGTTTTCCCGGGCAACGACTCCACGGCGTCTCAGGACGTGGCCAACCGCTTCGCCC
GCAAAGGGGCGCTGAGGCAGAAGAACGTGCACGAGGTGAAGGACCACAAATTCATCGCGCGCTTCTTCAAGCAGCCCACCTTCTGCAGCC
ACTGCACCGACTTCATCTGGGGGTTTGGGAAACAAGGCTTCCAGTGCCAAGTTTGCTGTTTTGTGGTCCACAAGAGGTGCCATGAATTTG
TTACTTTTTCTTGTCCGGGTGCGGATAAGGGACCCGACACTGATGACCCCAGGAGCAAGCACAAGTTCAAAATCCACACTTACGGAAGCC
CCACCTTCTGCGATCACTGTGGGTCACTGCTCTATGGACTTATCCATCAAGGGATGAAATGTGACACCTGCGATATGAACGTTCACAAGC
AATGCGTCATCAATGTCCCCAGCCTCTGCGGAATGGATCACACTGAGAAGAGGGGGCGGATTTACCTAAAGGCTGAGGTTGCTGATGAAA
AGCTCCATGTCACAGGAGATGTTGGCACACCTGAAACCATGGCCCCAACCATTGTGGTTCCCCCGGGCAACAGAAGTGTGGTGGCTGGAT
CCAGTGAGACCACCTTGGAATGTATAGCCAGTGCCAGGCCTGTGGAGGACCTGAGTGTGACCTGGAAGAGGAATGGAGTGAGAATCACCA
GTGGCCTCCACAGCTTTGGAAGACGCCTCACCATCAGCAACCCGACGTCCGCGGACACCGGGCCATACGTCTGCGAGGCGGCGCTGCCGG
GGAGCGCTTTTGAACCGGCCAGGGCGACGGCCTTTCTTTTCATCATAGAGCCACCATATTTTACTGCTGAGCCCGAGAGTCGGATTTCAG
CTGAAGTAGAAGAAACTGTGGACATCGGATGTCAAGCCATGGGGGTCCCCCTTCCCACCCTCCAGTGGTACAAGGATGCCATCTCCATCA
GCAGGCTCCAGAATCCTCGATACAAAGTGCTCGCCAGCGGAGGCCTGCGCATCCAGAAGCTGCGTCCAGAGGACTCCGGAATCTTCCAGT
GCTTCGCCAGCAATGAAGGAGGGGAGATCCAGACCCACACCTACCTGGATGTAACCAATATCGCTCCAGTGTTCACCCAGCGGCCAGTGG
ACACCACAGTTACTGACGGGATGACAGCCATTCTAAGGTGTGAGGTGTCCGGGGCTCCCAAACCCGCCATCACCTGGAAAAGAGAAAACC
ACATTCTGGCCAGTGGCTCTGTCCGGATTCCTAGGTTCATGCTTCTTGAATCGGGGGGTCTACAGATCGCGCCCGTCTTCATCCAGGATG
CCGGCAACTACACCTGCTATGCGGCCAACACAGAGGGCTCCCTGAATGCATCGGCCACGCTCACTGTGTGGAATCGGACGTCCATCGTCC
ACCCTCCTGAGGACCACGTGGTGATTAAGGGGACCACGGCCACGCTGCACTGTGGTGCCACACATGACCCCCGGGTTTCACTCCGCTACG
TTTGGAAGAAGGACAACGTGGCCCTGACTCCATCGAGCACGTCTAGGATCGTGGTGGAGAAGGACGGGTCCCTTCTCATCAGCCAGACGT
GGTCAGGCGACATCGGTGACTACAGCTGCGAGATTGTTTCTGAAGGAGGGAATGACTCCAGGATGGCCCGGCTGGAAGTGATTGAACTGC
CTCATTCACCTCAGAACCTCCTGGTCAGCCCTAATTCTTCCCACAGCCACGCCGTGGTGCTCTCTTGGGTCCGGCCCTTTGATGGAAACA
GTCCTATTCTTTATTACATCGTGGAGCTCTCTGAAAACAACTCTCCATGGAAGGTGCATCTGTCAAACGTTGGCCCTGAGATGACAGGCG
TCACCGTGAGTGGCCTGACTCCGGCTCGTACCTATCAATTCCGGGTGTGCGCGGTGAATGAAGTGGGCAGGGGCCAGTACAGCGCCGAGA
CAAGCAGGTTGATGCTACCTGAAGAACCACCCAGTGCTCCCCCGAAAAATATAGTGGCCAGTGGGCGGACTAATCAGTCCATTATGGTCC
AGTGGCAGCCACCCCCAGAAACAGAGCACAACGGGGTGTTGCGTGGATACATCCTCAGGTACCGCCTGGCTGGCCTTCCCGGAGAGTACC
AGCAGCGGAACATCACCAGCCCGGAGGTGAACTACTGCCTGGTGACAGACCTGATCATCTGGACACAGTATGAGATACAGGTGGCGGCGT
ACAACGGGGCCGGTCTGGGCGTCTTCAGCAGGGCAGTGACCGAGTACACCTTGCAGGGAGTGCCCACCGCGCCCCCGCAGAACGTGCAGA
CGGAAGCCGTGAACTCCACCACCATTCAGTTCCTGTGGAACCCTCCGCCTCAGCAGTTTATCAATGGCATCAACCAGGGATACAAGCTTC
TGGCATGGCCGGCAGATGCCCCCGAGGCTGTCACTGTGGTCACTATTGCCCCAGATTTCCACGGAGTCCACCATGGACACATAACGAACC
TGAAGAAGTTTACCGCCTACTTCACTTCCGTTCTGTGCTTCACCACCCCTGGGGACGGGCCTCCCAGCACACCTCAGCTGGTCTGGACTC
AGGAAGACAAACCAGGAGCTGTGGGACATCTGAGTTTCACAGAGATCTTGGACACATCTCTCAAGGTCAGCTGGCAGGAGCCCCTGGAGA
AAAATGGCATCATTACTGGCTATCAGATCTCTTGGGAAGTGTACGGCAGGAACGACTCTCGTCTCACGCACACCCTGAACAGCACGACGC
ACGAGTACAAGATCCAAGGCCTCTCATCTCTCACCACCTACACCATCGACGTGGCCGCTGTGACTGCCGTGGGCACTGGCCTGGTGACTT
CATCCACCATTTCTTCTGGAGTGCCCCCAGACCTTCCTGGTGCCCCATCCAACCTGGTCATTTCCAACATCAGCCCTCGCTCCGCCACCC
TTCAGTTCCGGCCAGGCTATGACGGGAAAACGTCCATCTCCAGGTGGATTGTTGAGGGGCAGGTGGGAGCTATCGGCGACGAGGAGGAGT
GGGTCACCCTCTATGAAGAGGAGAATGAGCCTGATGCCCAGATGCTGGAGATCCCAAACCTCACACCCTACACTCACTACAGATTTCGAA
TGAAGCAAGTGAACATTGTTGGGCCGAGCCCCTACAGTCCGTCTTCCCGGGTCATCCAGACCCTGCAGGCCCCACCCGACGTGGCTCCAA
CCAGCGTCACGGTCCGTACTGCCAGTGAGACCAGCCTGCGGCTTCGCTGGGTGCCCCTGCCGGATTCTCAGTACAACGGGAACCCCGAGT
CCGTGGGCTACAGGATTAAGTACTGGCGCTCAGACCTCCAGTCCTCAGCAGTGGCCCAAGTCGTCAGTGACCGGCTGGAGAGAGAATTCA
CCATCGAGGAGCTGGAGGAGTGGATGGAATACGAGCTGCAGATGCAGGCCTTCAACGCCGTCGGGGCTGGGCCGTGGAGCGAGGTGGTGC
GGGGCCGGACGCGGGAGTCAGTTCCTTCAGCCGCCCCTGAGAACGTGTCAGCCGAGGCTGTCAGCTCGACCCAGATTTTACTGACATGGA
CATCCGTGCCGGAACAGGACCAGAATGGGCTCATACTGGGCTACAAGATCCTGTTCCGGGCCAAAGACCTGGATCCCGAGCCCAGGAGCC
ACATCGTGCGAGGGAACCACACGCAGTCGGCCCTGCTGGCAGGCCTGCGCAAGTTCGTGCTCTACGAGCTCCAGGTGCTGGCGTTCACCC
GCATCGGGAACGGGGTCCCCAGCACGCCCCTCATCCTGGAGCGCACCAAAGACGATGCCCCAGGCCCACCAGTGAGGCTCGTGTTCCCCG
AAGTGAGACTCACCTCCGTGCGGATAGTGTGGCAACCTCCGGAGGAGCCCAACGGCATCATCCTGGGGTACCAGATTGCCTACCGCCTGG
CCAGCAGCAGCCCCCACACCTTCACCACCGTGGAGGTCGGCGCCACAGTGAGGCAGTTCACAGCCACCGACCTGGCCCCGGAGTCCGCAT
ACATCTTCAGGCTGTCCGCCAAGACGAGGCAGGGCTGGGGGGAGCCACTGGAGGCCACCGTCATCACCACCGAGAAGAGAGAGCGGCCGG
CACCCCCCAGAGAGCTCCTGGTGCCCCAGGCAGAAGTGACCGCACGCAGCCTCCGGCTCCAGTGGGTCCCGGGCAGCGACGGGGCCTCCC
CCATCCGGTACTTCACCATGCAGGTGCGAGAGCTGCCTCGGGGTGAGTGGCAGACCTACTCCTCGTCCATCAGCCATGAGGCGACAGCAT
GCGTCGTTGACAGACTGAGGCCCTTCACCTCCTACAAGCTGCGCCTGAAAGCCACCAACGACATTGGGGACAGTGACTTCAGTTCAGAGA
CAGAGGCGGTGACCACGCTGCAGGATGTTCCAGGAGAGCCCCCGGGATCTGTCTCAGCGACGCCACACACCACGTCCTCTGTCCTGATAC
AGTGGCAGCCTCCGAGGGACGAAAGCCTGAATGGCCTTCTTCAGGGATACAGGATCTACTACAGGGAGCTGGAGTATGAAGCCGGGTCAG
GCACTGAGGCCAAGACGCTCAAAAACCCTATAGCTTTACATGCTGAGCTCACAGATTTAAAGAAGTACCGGCGCTATGAAGTAATAATGA
CCGCCTATAACATCATCGGCGAGAGCCCAGCCAGCGCGCCCGTGGAGGTCTTTGTCGGCGAGGCTGCCCCGGCCATGGCCCCGCAGAACG
TGCAGGTGACCCCACTCACGGCCAGCCAGCTGGAGGTCACGTGGGACCCACCACCCCCGGAGAGCCAGAATGGGAACATCCAAGGCTACA
AGATTTACTACTGGGAGGCAGACAGCCAGAACGAAACGGAGAAAATGAAGGTCCTCTTCCTCCCCGAGCCCGTGGTGAGGCTGAAGAACC
TGACCAGCCATACCAAGTACCTGGTCAGCATATCAGCCTTCAACGCCGCCGGAGATGGACCTAAGAGTGACCCCCAGCAGGGGCGCACCC
ACCAGGCCGCCCCTGGGGCCCCCAGCTTTCTGGCGTTCTCAGAAATAACCTCCACCACGCTCAACGTGTCCTGGGGCGAGCCTGCGGCGG
CCAACGGCATCCTGCAGGGCTATCGGGTGGTGTACGAGCCCTTGGCCCCTGTACAAGGGGTGAGCAAGGTGGTGACCGTGGAAGTGAGAG
GGAACTGGCAGCGCTGGCTGAAGGTGCGGGACCTCACCAAGGGAGTGACCTATTTCTTCCGTGTCCAAGCGCGGACCATCACCTACGGGC
CCGAGCTCCAAGCCAATATCACAGCCGGGCCAGCCGAGGGATCCCCGGGCTCGCCTAGAGATGTCCTGGTCACCAAGTCCGCCTCTGAAC
TGACGCTGCAGTGGACTGAGGGACACTCTGGCGACACACCTACCACGGGCTATGTGATCGAGGCCCGGCCCTCAGATGAAGGCTTATGGG
ACATGTTTGTGAAGGACATCCCGCGGAGCGCCACATCCTACACCCTCAGCCTGGATAAGCTCCGGCAAGGAGTGACTTACGAGTTCCGGG
TGGTGGCTGTGAATGAGGCGGGCTACGGGGAGCCCAGCAACCCCTCCACGGCTGTGTCAGCTCAAGTGGAAGCCCCATTCTACGAGGAGT
GGTGGTTCCTCCTGGTGATGGCTCTGTCCAGCCTGATCGTCATCCTGCTGGTGGTGTTCGCCCTCGTCCTGCACGGGCAGAATAAGAAGT
ATAAGAACTGCAGCACAGGAAAGGGGATCTCCACCATGGAGGAGTCTGTGACCCTGGACAACGGAGGATTTGCTGCCCTGGAGCTCAGCA
GCCGCCACCTCAATGTCAAGAGCACCTTCTCCAAGAAGAACGGGACCAGGTCCCCACCCCGGCCTAGCCCCGGCGGCCTGCACTACTCAG
ACGAGGACATCTGCAACAAGTACAACGGCGCCGTGCTGACCGAGAGCGTGAGCCTCAAGGAGAAGTCGGCAGATGCATCAGAATCTGAGG
CCACGGACTCTGACTACGAGGACGCGCTGCCCAAGCACTCCTTCGTGAACCACTACATGAGCGACCCCACCTACTACAACTCATGGAAGC
GCAGGGCCCAGGGCCGCGCACCTGCGCCGCACAGGTACGAGGCGGTGGCGGGCTCCGAGGCGGGCGCGCAGCTGCACCCGGTCATCACCA
CGCAGAGCGCGGGCGGCGTCTACACCCCCGCTGGCCCCGGCGCGCGAACTCCGCTCACCGGCTTCTCCTCCTTCGTGTGAGCAAAGCGCC
GCGCCTCCCTCAGGGCGGAACGGAGGCAACTTTCCGGAGTCTATTTTTGTTAAGACAATCAACTCCAATAACTGAGCTGAAGTTTTTGTT
TAAAAAGAAAAAAATCTGATAAGTGATGATTTTACCTACTTGTGGACACTAGATTTCAATTAGGAAGGTTTTTTTAAACGGCTTTTTGTA
ACTTCGCTGCAGGAAGCAGGTTTGTTTCTTTTTCTTTTCTTTTTAAGAGAAGGTGTATTTCACTGGTGCAATGGCTTGGCACCTCCGGGG
CCTGGGAGGACCTCAGACCTCCCCAGCCCTGGGTTTCTCCGTCTTCAAGACCAACTAGGAAGGGTCAAGCGGGGAGAGGGAGTGGAGGGT
CAGGTGAGATCTCAGAGCTGCCCCGGCCGGCCCCCGTCTCTTTCTACCTCCTCTTCCAGAGAACCAGCGGCTCACACCCTTCTCAACGCA
GGACATCCTCGGCGGCTCCTGGGGTTTGAAGAGCAAACGTTTTTCCCTGGGCTCAGTGCGTTTTGTCCCAACTTCATCTGTTTCTGAAAT
GTTCTCACTTGGCAGTGTCTAGTCAAGGAGTCGGCTTTCAGGTTCCTGACGGCCAGGCAGGGATGCTAAGGTGTGGCTCAGCCGTCACTG
TCTGTGTCACTGCAGTGGTGCGGTCCTCAGGCTTTTCTGCCTGTCTTTCCCCCTTCCTTCTCACCTGACAGCGAGGGAGAGGGAAGCCTC
TTAGGGCTGGAAGCCACCACGCTGGCCCTCTCCTTCCCCGAACACAGCACACGGTCAACTCCGCGGGACACGAGGACACGGGACGGCGTC
TCCAGAATTGCTTGTTACGTAGGAAGCGTGCATTGTTAACCAGAGTATTTTTAAAATCTTTTTATCTTTTTTTAAACTATGTCACATGAA
ATGAATGCGTCTTTGCTGTCTCCAGGTGCCTTTTTATTAATTGTTCAGCTTTGTACATGGGAAAGATGAAAAGCAACAGTGTCTGCAAAT

>In-frame_ENST00000413366_ENST00000389531_TCGA-66-2793-01A_PRKCA_chr17_64641629_-_SDK1_chr7_3990555_length(amino acids)=2091AA_start in transcript=14_stop in transcript=6289
MGGTMADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC
PGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVT
GDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHSFGRRLTISNPTSADTGPYVCEAALPGSAFE
PARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASN
EGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYT
CYAANTEGSLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDI
GDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSG
LTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNI
TSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPA
DAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGII
TGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRP
GYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTV
RTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTR
ESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNG
VPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRL
SAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDR
LRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAK
TLKNPIALHAELTDLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYW
EADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGIL
QGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGSPRDVLVTKSASELTLQW
TEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAPFYEEWWFLL
VMALSSLIVILLVVFALVLHGQNKKYKNCSTGKGISTMEESVTLDNGGFAALELSSRHLNVKSTFSKKNGTRSPPRPSPGGLHYSDEDIC
NKYNGAVLTESVSLKEKSADASESEATDSDYEDALPKHSFVNHYMSDPTYYNSWKRRAQGRAPAPHRYEAVAGSEAGAQLHPVITTQSAG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PRKCA-SDK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PRKCA-SDK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PRKCA-SDK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePRKCAC0036341Schizophrenia2PSYGENET
HgenePRKCAC0002152Alloxan Diabetes1CTD_human
HgenePRKCAC0011853Diabetes Mellitus, Experimental1CTD_human
HgenePRKCAC0018800Cardiomegaly1CTD_human
HgenePRKCAC0021841Intestinal Neoplasms1CTD_human
HgenePRKCAC0032617Polyuria1CTD_human
HgenePRKCAC0033975Psychotic Disorders1PSYGENET
HgenePRKCAC0036337Schizoaffective Disorder1PSYGENET
HgenePRKCAC0038433Streptozotocin Diabetes1CTD_human
HgenePRKCAC0162283Nephrogenic Diabetes Insipidus1CTD_human
HgenePRKCAC0264423Asthma, Occupational1CTD_human
HgenePRKCAC0268443Acquired Nephrogenic Diabetes Insipidus1CTD_human
HgenePRKCAC0346627Intestinal Cancer1CTD_human
HgenePRKCAC0349204Nonorganic psychosis1PSYGENET
HgenePRKCAC0400966Non-alcoholic Fatty Liver Disease1CTD_human
HgenePRKCAC0677501Congenital Nephrogenic Diabetes Insipidus1CTD_human
HgenePRKCAC1383860Cardiac Hypertrophy1CTD_human
HgenePRKCAC1563705Nephrogenic Diabetes Insipidus, Type I1CTD_human
HgenePRKCAC1563706Nephrogenic Diabetes Insipidus, Type II1CTD_human
HgenePRKCAC3241937Nonalcoholic Steatohepatitis1CTD_human
HgenePRKCAC3542500ADH-Resistant Diabetes Insipidus1CTD_human