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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:PRPF3-OTUD7B (FusionGDB2 ID:68591) |
Fusion Gene Summary for PRPF3-OTUD7B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PRPF3-OTUD7B | Fusion gene ID: 68591 | Hgene | Tgene | Gene symbol | PRPF3 | OTUD7B | Gene ID | 9129 | 56957 |
| Gene name | pre-mRNA processing factor 3 | OTU deubiquitinase 7B | |
| Synonyms | HPRP3|HPRP3P|PRP3|Prp3p|RP18|SNRNP90 | CEZANNE|ZA20D1 | |
| Cytomap | 1q21.2 | 1q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | U4/U6 small nuclear ribonucleoprotein Prp3PRP3 pre-mRNA processing factor 3 homologU4/U6 snRNP 90 kDa proteinU4/U6-associated RNA splicing factorpre-mRNA-splicing factor 3 | OTU domain-containing protein 7BOTU domain containing 7Bcellular zinc finger anti-NF-kappa-B proteincellular zinc finger anti-NF-kappaB Cezannezinc finger A20 domain-containing protein 1zinc finger protein Cezannezinc finger, A20 domain containing 1 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000324862, ENST00000543398, ENST00000414970, ENST00000467329, | ENST00000369135, ENST00000479905, | |
| Fusion gene scores | * DoF score | 7 X 7 X 6=294 | 8 X 10 X 4=320 |
| # samples | 7 | 8 | |
| ** MAII score | log2(7/294*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/320*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PRPF3 [Title/Abstract] AND OTUD7B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | PRPF3(150318967)-OTUD7B(149943179), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PRPF3 | GO:0000244 | spliceosomal tri-snRNP complex assembly | 20595234 |
| Hgene | PRPF3 | GO:0000398 | mRNA splicing, via spliceosome | 28781166 |
| Tgene | OTUD7B | GO:0000122 | negative regulation of transcription by RNA polymerase II | 21097510 |
| Tgene | OTUD7B | GO:0032717 | negative regulation of interleukin-8 production | 21097510 |
| Tgene | OTUD7B | GO:0035871 | protein K11-linked deubiquitination | 20622874|23827681 |
| Tgene | OTUD7B | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling | 11463333 |
| Tgene | OTUD7B | GO:0070536 | protein K63-linked deubiquitination | 20622874 |
| Tgene | OTUD7B | GO:0071108 | protein K48-linked deubiquitination | 21097510 |
| Tgene | OTUD7B | GO:1900181 | negative regulation of protein localization to nucleus | 21097510 |
| Fusion gene breakpoints across PRPF3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across OTUD7B (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SARC | TCGA-DX-A23U-01A | PRPF3 | chr1 | 150318967 | + | OTUD7B | chr1 | 149943179 | - |
| ChimerDB4 | SARC | TCGA-DX-A23U | PRPF3 | chr1 | 150318967 | + | OTUD7B | chr1 | 149943179 | - |
| ChimerDB4 | SARC | TCGA-DX-A23U-01A | PRPF3 | chr1 | 150318967 | - | OTUD7B | chr1 | 149943179 | - |
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Fusion Gene ORF analysis for PRPF3-OTUD7B |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000324862 | ENST00000369135 | PRPF3 | chr1 | 150318967 | + | OTUD7B | chr1 | 149943179 | - |
| 5CDS-5UTR | ENST00000324862 | ENST00000479905 | PRPF3 | chr1 | 150318967 | + | OTUD7B | chr1 | 149943179 | - |
| intron-3CDS | ENST00000543398 | ENST00000369135 | PRPF3 | chr1 | 150318967 | + | OTUD7B | chr1 | 149943179 | - |
| intron-5UTR | ENST00000543398 | ENST00000479905 | PRPF3 | chr1 | 150318967 | + | OTUD7B | chr1 | 149943179 | - |
| In-frame | ENST00000414970 | ENST00000369135 | PRPF3 | chr1 | 150318967 | + | OTUD7B | chr1 | 149943179 | - |
| 5CDS-5UTR | ENST00000414970 | ENST00000479905 | PRPF3 | chr1 | 150318967 | + | OTUD7B | chr1 | 149943179 | - |
| 3UTR-3CDS | ENST00000467329 | ENST00000369135 | PRPF3 | chr1 | 150318967 | + | OTUD7B | chr1 | 149943179 | - |
| 3UTR-5UTR | ENST00000467329 | ENST00000479905 | PRPF3 | chr1 | 150318967 | + | OTUD7B | chr1 | 149943179 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000324862 | PRPF3 | chr1 | 150318967 | + | ENST00000369135 | OTUD7B | chr1 | 149943179 | - | 10506 | 2008 | 165 | 4454 | 1429 |
| ENST00000414970 | PRPF3 | chr1 | 150318967 | + | ENST00000369135 | OTUD7B | chr1 | 149943179 | - | 10282 | 1784 | 88 | 4230 | 1380 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000324862 | ENST00000369135 | PRPF3 | chr1 | 150318967 | + | OTUD7B | chr1 | 149943179 | - | 0.000451746 | 0.99954826 |
| ENST00000414970 | ENST00000369135 | PRPF3 | chr1 | 150318967 | + | OTUD7B | chr1 | 149943179 | - | 0.000412316 | 0.9995877 |
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Fusion Genomic Features for PRPF3-OTUD7B |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for PRPF3-OTUD7B |
| Go to FGviewer for the breakpoints of chr1:150318967-chr1:149943179 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PRPF3 | chr1:150318967 | chr1:149943179 | ENST00000324862 | + | 14 | 16 | 579_584 | 614.3333333333334 | 684.0 | Compositional bias | Note=Poly-Val |
| Hgene | PRPF3 | chr1:150318967 | chr1:149943179 | ENST00000324862 | + | 14 | 16 | 1_87 | 614.3333333333334 | 684.0 | Domain | PWI |
| Tgene | OTUD7B | chr1:150318967 | chr1:149943179 | ENST00000369135 | 1 | 12 | 183_365 | 28.333333333333332 | 844.0 | Domain | OTU | |
| Tgene | OTUD7B | chr1:150318967 | chr1:149943179 | ENST00000369135 | 1 | 12 | 483_498 | 28.333333333333332 | 844.0 | Motif | Nuclear localization signal | |
| Tgene | OTUD7B | chr1:150318967 | chr1:149943179 | ENST00000369135 | 1 | 12 | 152_401 | 28.333333333333332 | 844.0 | Region | Note=TRAF-binding | |
| Tgene | OTUD7B | chr1:150318967 | chr1:149943179 | ENST00000369135 | 1 | 12 | 167_440 | 28.333333333333332 | 844.0 | Region | Note=Catalytic | |
| Tgene | OTUD7B | chr1:150318967 | chr1:149943179 | ENST00000369135 | 1 | 12 | 187_193 | 28.333333333333332 | 844.0 | Region | Regulatory loop | |
| Tgene | OTUD7B | chr1:150318967 | chr1:149943179 | ENST00000369135 | 1 | 12 | 796_831 | 28.333333333333332 | 844.0 | Zinc finger | A20-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for PRPF3-OTUD7B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000324862_ENST00000369135_TCGA-DX-A23U-01A_PRPF3_chr1_150318967_+_OTUD7B_chr1_149943179_length(transcript)=10506nt_BP=2008nt GGAGACAGCGGCGTGGCGGCGGCGGTGGCGGTAGCGACGGCACGCCGTAGGGCGGTCAGAAGGTTTCCGGTTCCGGTGTAACGTTCGGGC TCCGTCTCAGGGGCTGAAGTTTGTGAGGTGTAGTATTGAGTCCTGTTTGAGCTATTGTTCTCTTTTTCCTGAAAAATGGCACTGTCAAAG AGGGAGCTGGATGAGCTGAAACCATGGATAGAGAAGACAGTGAAGAGGGTCCTGGGTTTCTCAGAGCCTACGGTGGTCACAGCAGCATTG AACTGTGTGGGGAAGGGCATGGACAAGAAGAAGGCAGCCGATCATCTGAAACCTTTTCTTGATGATTCTACTCTCCGATTTGTGGACAAA CTGTTTGAGGCTGTGGAGGAAGGCCGAAGCTCTAGGCATTCCAAGTCTAGCAGTGACAGGAGCAGAAAACGAGAGCTAAAGGAGGTGTTT GGTGATGACTCTGAGATCTCTAAAGAATCATCAGGAGTAAAGAAGCGACGAATACCCCGTTTTGAGGAGGTGGAAGAAGAGCCAGAGGTG ATCCCTGGGCCTCCATCAGAGAGCCCTGGCATGCTGACTAAGCTCCAGATCAAACAGATGATGGAGGCAGCAACACGACAAATCGAGGAG AGGAAAAAACAGCTGAGCTTCATTAGCCCCCCTACACCTCAGCCAAAGACTCCTTCTTCCTCCCAACCAGAACGACTTCCTATTGGCAAC ACTATTCAGCCCTCCCAGGCTGCCACTTTCATGAATGATGCCATTGAGAAGGCAAGGAAAGCAGCTGAACTGCAAGCTCGAATCCAAGCC CAGCTGGCACTGAAGCCAGGACTCATCGGCAATGCCAACATGGTGGGCCTGGCTAATCTCCATGCCATGGGCATTGCTCCCCCGAAGGTG GAGTTAAAAGACCAAACGAAACCTACACCACTGATCCTGGATGAGCAAGGGCGCACTGTAGATGCAACAGGCAAGGAGATTGAGCTGACA CACCGCATGCCTACTCTGAAAGCCAATATTCGTGCTGTGAAGAGGGAACAATTCAAGCAACAACTAAAGGAAAAGCCATCAGAAGACATG GAATCCAATACCTTTTTTGACCCCCGAGTCTCCATTGCCCCTTCCCAGCGCCAGAGACGCACTTTTAAATTCCATGACAAGGGCAAATTT GAGAAGATTGCTCAGCGATTACGGACAAAGGCTCAACTGGAGAAGCTACAGGCAGAGATTTCACAAGCAGCTCGAAAAACAGGCATCCAT ACTTCGACTAGGCTTGCCCTCATTGCTCCTAAGAAGGAGCTAAAGGAAGGAGATATTCCTGAAATTGAGTGGTGGGACTCTTACATAATC CCCAATGGCTTTGATCTTACAGAGGAAAATCCCAAGAGAGAAGATTATTTTGGAATCACAAATCTTGTTGAACATCCAGCCCAGCTCAAT CCTCCAGTTGACAATGACACACCAGTTACTCTGGGAGTATATCTTACCAAGAAGGAACAGAAAAAACTTCGGAGACAAACAAGGAGGGAA GCACAGAAGGAACTACAAGAAAAAGTCAGGCTGGGCCTGATGCCTCCTCCAGAACCCAAAGTGAGAATTTCTAATTTGATGCGAGTATTA GGAACAGAAGCTGTTCAAGACCCCACGAAGGTAGAAGCCCACGTCAGAGCTCAGATGGCAAAAAGACAGAAAGCGCATGAAGAGGCCAAC GCTGCCCGAAAACTCACAGCAGAACAGAGAAAGGTCAAGAAAATTAAAAAGCTTAAAGAAGACATTTCACAGGGGGTACACATATCTGTA TATAGAGTTCGAAATTTGAGCAACCCAGCCAAGAAGTTCAAGATTGAAGCCAATGCTGGGCAACTGTACCTGACAGGGGTGGTGGTACTG CACAAGGATGTCAACGTGGTAGTAGTGGAAGGGGGCCCCAAGGCCCAGAAGAAATTTAAGCGTCTTATGCTGCATCGGATAAAGTGGGAT GAACAGACATCTAACACAAAGGGAGATGGAAAGAATTGGGATGTGAATGCCGCCCTCAGTGATTTTGAACAGCTACGTCAAGTCCATGCT GGAAACCTACCCCCATCCTTTAGTGAGGGGAGTGGTGGCTCCAGGACCCCTGAAAAAGGGTTTTCTGACAGAGAGCCTACTCGCCCTCCC CGACCCATCCTCCAGCGGCAGGATGACATCGTTCAAGAAAAACGCCTGTCTAGGGGCATCTCCCACGCCAGCTCCAGCATTGTTTCCCTG GCCCGGTCCCATGTCTCCTCCAATGGTGGGGGTGGGGGGAGCAATGAGCACCCCCTGGAAATGCCCATCTGTGCCTTCCAGCTTCCAGAT CTCACTGTATACAATGAAGACTTCCGCAGCTTCATAGAGAGAGACCTCATTGAGCAGTCCATGCTGGTTGCCTTGGAACAGGCAGGGCGT TTGAACTGGTGGGTGAGTGTGGATCCCACCTCTCAGAGGCTGCTTCCTTTGGCAACTACTGGAGATGGGAACTGCCTCCTGCATGCAGCC TCCCTTGGAATGTGGGGTTTCCATGATCGGGACTTGATGCTGCGGAAAGCTTTGTATGCACTGATGGAGAAGGGAGTTGAGAAGGAAGCG TTGAAAAGGCGCTGGAGGTGGCAGCAGACACAGCAGAATAAAGAGTCAGGGCTGGTATACACAGAAGATGAATGGCAGAAGGAGTGGAAT GAACTGATCAAGCTTGCCTCAAGTGAACCCCGAATGCATCTAGGTACCAATGGAGCCAACTGTGGTGGGGTGGAGAGTTCTGAGGAGCCT GTATATGAGAGCCTTGAAGAGTTTCACGTCTTTGTCCTTGCTCATGTGCTTAGGAGGCCCATAGTCGTCGTGGCAGACACCATGCTGAGG GACTCCGGAGGGGAAGCATTTGCCCCTATTCCCTTTGGAGGAATCTATCTGCCTTTGGAGGTCCCAGCCAGCCAGTGTCACCGCTCCCCT CTGGTGCTCGCCTATGATCAGGCCCACTTTTCTGCACTCGTGTCCATGGAGCAGAAGGAGAATACCAAGGAACAAGCTGTGATCCCACTT ACAGATTCAGAGTATAAGCTGCTGCCCTTGCACTTTGCTGTGGACCCTGGAAAGGGCTGGGAGTGGGGCAAAGATGATAGTGACAATGTC CGATTGGCCAGTGTAATTCTGTCCCTAGAGGTCAAATTGCATCTGCTGCATAGCTACATGAATGTGAAGTGGATCCCACTGTCCTCTGAT GCACAGGCTCCTCTGGCCCAGCCTGAGTCCCCCACCGCCTCAGCTGGAGATGAGCCCCGGTCCACTCCTGAGTCTGGAGACTCAGACAAG GAGTCAGTTGGCAGCAGTTCCACCAGCAACGAGGGCGGCCGGCGGAAGGAGAAGTCAAAGCGAGATCGGGAGAAGGACAAGAAGAGAGCA GATTCTGTGGCTAACAAACTGGGCAGCTTTGGCAAAACCTTGGGCAGCAAGCTCAAGAAGAACATGGGGGGCCTGATGCACAGCAAGGGT TCAAAGCCTGGAGGGGTGGGGACAGGGTTGGGAGGAAGCAGCGGCACTGAGACACTGGAGAAGAAGAAGAAAAACTCACTGAAGAGCTGG AAGGGTGGCAAGGAGGAGGCAGCTGGGGATGGGCCTGTGTCTGAGAAGCCCCCAGCTGAGTCTGTTGGTAACGGAGGGAGCAAGTATAGC CAGGAGGTGATGCAGAGCCTGAGCATTCTGAGGACTGCCATGCAAGGGGAGGGGAAGTTTATTTTTGTTGGAACCCTGAAGATGGGTCAC CGTCACCAGTATCAGGAGGAAATGATCCAGCGCTACCTTTCTGATGCTGAGGAGAGATTCCTGGCAGAACAGAAGCAGAAGGAGGCAGAG AGGAAGATCATGAATGGAGGAATAGGGGGTGGCCCTCCTCCAGCCAAAAAGCCAGAGCCAGATGCTAGGGAAGAGCAGCCGACCGGTCCC CCAGCAGAGTCCAGGGCAATGGCATTTTCCACTGGCTACCCTGGGGACTTTACTATCCCTCGGCCGTCTGGGGGCGGAGTCCACTGCCAG GAACCCCGGAGGCAGTTGGCAGGGGGTCCATGTGTCGGGGGCCTACCACCATATGCCACCTTCCCCAGACAGTGCCCTCCTGGGCGACCC TACCCCCACCAGGACAGCATCCCTTCTCTGGAGCCAGGCAGCCACTCTAAGGATGGACTTCACAGGGGTGCCTTGTTACCACCCCCCTAC CGAGTGGCTGATTCCTATAGCAATGGCTACAGAGAGCCCCCTGAGCCAGATGGATGGGCTGGAGGTCTCCGGGGCCTTCCCCCAACTCAG ACCAAATGCAAACAACCGAACTGCAGCTTCTATGGACACCCTGAGACAAACAACTTCTGTTCCTGTTGTTACAGGGAAGAACTGAGGAGG AGGGAGCGGGAACCGGATGGGGAGCTCCTGGTGCACAGGTTCTGAACGGGTGGAACACTGAAGGGCAAGGAGGCTAAACAAAGTTAAGCT CAACTAATTGGCTCATCAAGAACACAGTCCCCATGTTGAGGGGGAAAATGCAGTAATGTTTGTGGGAGCCTGGCTGGAAACTTTTAAGTG TGTGCACACAGGAGTGCTGCCAGGCTGGCAAGAGCAGGTCGGGGCTGGATGGCACCTCAGGGGCTGTACTATTCCTCTGCAGAGCTTGAC TTGATGAGGTTTGAGGTACAAGGGGAAAAGATGGCGATTCTGTCTTATAACCTCCTGGGTCCCATCCAGGGACCTAAGAGAAAGTAGCAG GGGAAGGTTTGGTGTGTGGGGGTGGGAGGTGGGCAGAAGTCTTGGGGAGGAATGGGCAAAGGAGGTTCTCAGTCAATAAAACCAAAGTTC TTTAGGTTGGGAAAAAGCACATGGTGGAGTGAGAAGTGTGGAGGGGAAGTGGGAAATTGGACACATTTGCTATTGATTTGAATTAAGCTA GAAATTAAGGTTGGATAAATTCTTCCCCTTGAAGGATCTGGAAAGACAAGGCAGTAATGTGTCCTCATGGGTGCCTGTTAGGAGGTGGGG GTAGTTTAAATCCGTTTGTTTAGATGGGAAAGGGAGGAACTTAAGAGGGAAATCCTTTTCCTCTTAAGGTTTATTTCCTTCCAAGCAGTC ATATGTCATCTGTTACAGTTTGAGAAGAGATTGCTGATTACCCCCTGTCTTTTCCTCATCTAAGTCTTTAATTGTATTTGTTTAAAGGGA AGAGTGTGGTGAGAACAGCCGTCATGTGTGTTGCATTTTCTCCAGGTGAATTGGGGCAGAGCTGATCTATTTTTTAACCACAGCAATAAC CATACGTTGGGGTTTGAGTGCACCTTGGGAGGGGTGGGAGGACAGACATTTTAGCCAGAGGCTGTTTCAAACAAAACCAAAAACCTAAGT AGAGCATTACAGGCCTCTGTGGCTGCTGCGTTTCTGTAGAAAGCAACTTATTTTATTGACTTTTTTTTTTAAGGAAAAGAAATAAAAAGA CCCCAGCAAGCAAAAACATTTAAAAAATGATTTTTTTCCCTCCTACTTAAGTGGTTCTTTCTCCCTTTGCTCTACTTTTGGAGAATGAAC TTAACATCCCGGCTTCTTTTGTTAAGCCATAGCTGACCTTAATCTGTGGTTAGTTTATTAAAATAATTAAAAATACTTTCTAAGAAGAGA TATTTTTGATATTAGGACTGATGTTGAAACATATAGGGGCAATTTATAAAAAGGTAGTTAGAGAAATATATTTTAGTGAACTATAACCAC AGAGCACAGATGACTCCCAATGAGCTGATCTGTCTTTAGGTTTCTCCCTTTCCCTGACCCTTCCCTGTTCTCTAGGGGCTGGGAGTGGGG ATGCGGACACAGTAGGGGGAGCTCCTTCGCATTTTGCACAAAGCACAAGTCTGAACAGCCTATGCTCTGGCCAGAGCCATTTCTAAGAGC TTTAAACCGGAAGACCTATCCTGGGCCAATTTTCCTTTTTCTTTATATTTTTTTCCGGGAAAAAAAGTCAACTATGCAATTGTATACACT CCCGGGTGCATGTGAAGAAGGGGAATAAGTGTACTTATGTGTCCAGAGTATTAACTGGGGCTGTTTTTCTGTGTTTGGATTTCTCTTTTG AGGTATGTACTCATAACCCATCCCTTGGAACGTAATCCCCACATTTGATCTAAAGCACTTGAGCGTGCATGCATGTGCGTGCGTGCATAT GTGTGTGTGTTTTCCTCCTCGGTAGCCAGTCAAGATTGTCCTTGTTGGAAATGCTCACGGTTTATAAAGGTTATTTTCTCCTCAACAAAC TCAGAAGTCACCTATTTTCCAAATCTGATTTAATAATTTCCTATGGCTATTAATTCTTAGGGTTTTCTTTGAAAATAGATTTGTGTTAAG GAAGCAGTGAGATTCCAAAGGAAGGGATGTGTATATGTCTAGGCAGGTCTGGAACCTGGTATGAGATGAGCACTCCCCTAAGTTGCAAAA TTTAAGGGTTACTATAAAACTCATTAATCAAGATACTATAAAAAATGCAGTATTTAAAAAAATTAATGCAAAAAATTTATGTTGGATAAA ATAGCGAAATCTTACAGGATCTGACAGGACTGAGATTAGGAGGAGGGAAGTGAGGCTGAATTGAATAAGTATGGGGATGAATCCTTCTTA TTTAAATTTTTGATACATTGTCCATCATAGACTTTTTACATTAATTGTGATTTTTTAAAAATGTTGCATTAAAATAGTATTTATCTTGGT TACTGGGTTTTTTGGCACTCCTTAAATTTTGTGCCCAAGGTGAGTGCTTTGCTCACCTCACCCTAGTTACGTCCCTGTTTCTGTGATTTG AACACTAGCGAGAACACCACTGTGTGCGCCTCCACCCCCATCACACACCAAACAACAGGTGGCTCAGACACCCTGAATTTGCACAGCTCA CCTAGCTTTCCTAATTTAGGCCTTCATATCATAGAATGGTGGCCTGGACCAATAGGAATGAAAACAGACCAGGGGTTTTCCCAGAGAATA AAGCCGGAAAAGTTTTGATTCTCCACTGGACTGCTGTGTTTGGATTTGATCTGTTGTTAGATTCTAGTTAACACTTTTGTTTTTAAAAAC TAAGGACAAATGAACAAAAAACCTTGTATCATGTTTGTTTTTATTTATAAGTTAGCCAATCCCAATTCCGTTTGCTTTATTTTCAAATAA AAAAAGATGGAAATTTTGAGGGGTGGTCTAGGGGTGAATATGGTAAAATGGGGCTTTAGGCCTTATAGCTTTTTATTAAGAAATAAATTA TTTTTTTTATTTGGGAGGGTAACTATTTATTGAGGCATTGAAAAACCTCTCCATTCTAAGGATGAGAGACCCTGAGACAATGGATATTTT TTATAGGAGATAGTGAAGTTTGTTTTGCTTCATTCTTTCGGGGAGGGTTTTGGTGGGATGGGGGGAGGTGAAGGAATAATGCCTGGGAAA TTAATATAGATTCAGCTTGGTTTGTGGTATTTTGGGAAGATGAGGGAATAGAAGAGGCAAGCCCATGTCGTTACTGGGTTGGGGAGAAGG AAAGAAGGGGCATATGGCCTGCACTCGAAATGGGCAGAAAAATTCCTTAGTTAAGGAGGGGTGTGTGAGTGAAGGGGGAAGGTAGACCCT TTAACCCCAAGTGAGGGATGATATCATCTCTCAGGCTTAAATTTAAGTGCACTTAGTTCCTTTAATCCAGGGCAACTGGGGTACCTACTG AAGTTTTTAATGGAGAGGGGAGATTTTCAGGGTTCTTGTTTTTCCCTTTTTGATGTTAGACAGTGCTACTCCCTCCCTGCTGTGCTCTCT GCCCCATCTCCAATGGAGTAAGTATTACTGTAGGATAGGCCTCCGCTTCTCCCTTAACCTATGCTGCATTTATTGAAAGTTACAAGATTT AACCAGAAGTTTTTCCTCCATACTGGTTTTTATCAACAAAATAAAAAGATTATATCCAAAGATTTTTTAAAGATTCAGTCTTTTTAAGGA GTGGAGATGGTGTTAAACTCAGTGCTGTAGAGGGCAGTGGAAGGGAAGTACCTTCCCTCTATTAGCTCAGTTTTTTTTTTTCTATCAAGC GAAACTAAGGCCCACAGACAAACAAGAATTAGCAGTGACTTCGTGTTGTATATCTGCGGGGTGATACTGAGCCCAAAAGAATAAAGCTGG TTTTGAATGTGTTCTGAGAACCTAGCTTTTGCCATTCTTAACTCCTTTTAGCCATGTGTCCAAGGTTCCAGTCACATTTTTTTTCTCAAT AAAGAGTATTTCAGAGATGATTGTCTCTGAATTACTCAGACACCTCTGGACTCTGAGTCTTCTTTCTTTTTCCTTTTTCTTTCTTTCTTT TTTTTTTGGTTTGAGACGGAGTCTCGCTCAGCTGCCCAGGCTGGAGTGCAGTGGTGCAATCTCGGCTCACTCCAACCACCGTCTCCTGGG TTCAAGTGATTCTCCTGTCTCAGCCTCCCAGGTGGCTGGGATTACAGGCACCCGCAATCATGCCCGGCTAATTTTTGTATTTTAGTAGAG ATGGGGTTTCACCATGTTGGCCAGGCTGATCTTGAACTCCTGACCTCAGGTGATCCGCCAGCCTCGGCCTCCCAAAGTGCTGGGATTACA GGCATGAGCCACCGCGACTGGCCTCTGTGTCTTCCTTCTCCAATGAGTCAGTGCCCCAGACATATAGCCACAGGTGAGAAGACAGAATTA GAAGCCCCTTCCCGGCCTGGAATCACCTGCACTCCAGATTTTTCTAATTTCCTTCTTTCCCTCCAGGCCTTTCAACTATAGATCTGGATG AGTCATGCAGGCATTCTGTCTCTTCTACTTTGCAGACAGCCAGTCTGCAAATCACAGGGTATTTTGCCACCATACATCAGTTGGGTAACA AAATATTACGATGTCCCCATGTAGACTTTCTCTGTGCCATCTCTTGCATTGGCCAAGTGGGTAAGGGGCAGTACAAAAGAGCAACGGAAG CTGGCTGGCAGCAGTTAAGAGGAGTAGGGGTGGGAAGGACCTTGGCCTCTTTCTGTGCTTATAACTGGATCTGTGACTCATCTTGTGAGT CACTCAGCTCCACCTCCCTCCTCCGGCTGCCCCTCCCAGCAGCCTTTACTCCTGGCACAAACCTGCAGCCAGAACAGGATTCTGAAAATG GAAAAATCTGATATAGCCCCTTGCCTCTCCACCCTTCCCTTCATCTAGTGCTTCTACTGGGGGTGTGTGGGGTGGTGAGAGGCAGCCTTA ACCCTCAGCTCCTGCCCACTCCATTCCTGGTTAAGTATTGATCCAAATCGCCCAATTCTTTTCTCCTCCTGATTTCCCCCCACCCCGCTT TTTTTTTTTTTTTTTTTTGAGACAGAGTTTCGCTCTTGTCGCCCAGGATGGAGTGCAATGGCGCGATCCCGGCTCACTGCAACCTTCGTC TCCTGGGTTCAAGCGATTCTCCTGCCTCAGGCTCCCGAGTAGCTGGGATTACAGGAGCCTACCACCATGCCTGGCTAATTTTTTTTTTTT TTTTTTTTTTTTTTTTAGTAGAGTCGGGGGTTTCGCCATGTTGGCCAGGCTGGTCTTGAATTCCTAACCTCAGGTGATCCGTGATCCACC CACCTCAGCCTTCCAAAGTGCTGGGATTACAGGCATGAGCCACCACACCCCTACCCCCCGATTTTTTTTCTCCGTGTTCCTCCACTGTCT CCACACCTCAAAGTGCTAAAGAATAGAATGAGGCTCTTGAATGAAGGATGGTGGTGAGAAGGAAAGTGGATAATGGGATTTAAAAGTTAT GGTACACACCTCTTCCTATGCTTTTTTTTTTTTTTTTTTTTTTTTTTGCGATGGAGTCTTGCTCTGTTGCCCAGGCTGGAGCGTAGTCAT TAGATCTTGGCTCACTGCAACCTCTGCTTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTATAGGTGTGAGC CACCACGCCTGGCTAATTTTTGTATTTTCAGTAGAGATGGGGCTTCATCATGTTGGCCAGGTGGTCCTGAACTCCTGACCTCAAGTAATC TGCCTGCCTTGGCCTTCCAAAATGCTTGGGATTACAGGCGTGAGCCACTGCGCCTGGTCCCTATTTTCTTTTTACAACAGACCTTGGGAA ATATTTTCTTCCCCCAAGAGGTTGAGGCCCATGGAATGCATTAGGGGCAGGTGGGGTGGTGGTGCTCTGTAGCCTTTAGGACTTCTAGAA TCAGGCTTCTGGGCCACCTTCTTAGCAGGTGTATACCTCTTTGTTCCAGACTGACTTTCTGTCTCACAATATCTTCACTATTTCCACAGT TGCAGCCAAGACAGGAAACTGAAAGCTGAGGCCAGAAGGGTGGTGTACTGGGGGGAGGGGAAAATTGAGTGTCACTTTGGAAAACTGGGG >In-frame_ENST00000324862_ENST00000369135_TCGA-DX-A23U-01A_PRPF3_chr1_150318967_+_OTUD7B_chr1_149943179_length(amino acids)=1429AA_start in transcript=165_stop in transcript=4454 MALSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDKKKAADHLKPFLDDSTLRFVDKLFEAVEEGRSSRHSKSSSDRSRKRE LKEVFGDDSEISKESSGVKKRRIPRFEEVEEEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQLSFISPPTPQPKTPSSSQPER LPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLALKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATGK EIELTHRMPTLKANIRAVKREQFKQQLKEKPSEDMESNTFFDPRVSIAPSQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAAR KTGIHTSTRLALIAPKKELKEGDIPEIEWWDSYIIPNGFDLTEENPKREDYFGITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRR QTRREAQKELQEKVRLGLMPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQRKVKKIKKLKEDISQG VHISVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDGKNWDVNAALSDFEQL RQVHAGNLPPSFSEGSGGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGGGGSNEHPLEMPICA FQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKG VEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVFVLAHVLRRPIVVVA DTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKD DSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQAPLAQPESPTASAGDEPRSTPESGDSDKESVGSSSTSNEGGRRKEKSKRDREK DKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNG GSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERKIMNGGIGGGPPPAKKPEPDAREE QPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGAL -------------------------------------------------------------- >In-frame_ENST00000414970_ENST00000369135_TCGA-DX-A23U-01A_PRPF3_chr1_150318967_+_OTUD7B_chr1_149943179_length(transcript)=10282nt_BP=1784nt GTAACGTTCGGGCTCCGTCTCAGGGGCTGAAGTTTGTGAGGTGTAGTATTGAGTCCTGTTTGAGCTATTGTTCTCTTTTTCCTGAAAAAT GGCACTGTCAAAGAGGGAGCTGGATGAGCTGAAACCATGGATAGAGAAGACAGTGAAGAGGGTCCTGGGTTTCTCAGAGCCTACGGTGGT CACAGCAGCATTGAACTGTGTGGGGAAGGGCATGGACAAGAAGAAGGCAGCCGATCATCTGAAACCTTTTCTTGATGATTCTACTCTCCG ATTTGTGGACAAACTGTTTGAGGCTGTGGAGGAAGGCCGAAGCTCTAGGCATTCCAAGTCTAGCAGTGACAGGAGCAGAAAACGAGAGCT AAAGATCAAACAGATGATGGAGGCAGCAACACGACAAATCGAGGAGAGGAAAAAACAGCTGAGCTTCATTAGCCCCCCTACACCTCAGCC AAAGACTCCTTCTTCCTCCCAACCAGAACGACTTCCTATTGGCAACACTATTCAGCCCTCCCAGGCTGCCACTTTCATGAATGATGCCAT TGAGAAGGCAAGGAAAGCAGCTGAACTGCAAGCTCGAATCCAAGCCCAGCTGGCACTGAAGCCAGGACTCATCGGCAATGCCAACATGGT GGGCCTGGCTAATCTCCATGCCATGGGCATTGCTCCCCCGAAGGTGGAGTTAAAAGACCAAACGAAACCTACACCACTGATCCTGGATGA GCAAGGGCGCACTGTAGATGCAACAGGCAAGGAGATTGAGCTGACACACCGCATGCCTACTCTGAAAGCCAATATTCGTGCTGTGAAGAG GGAACAATTCAAGCAACAACTAAAGGAAAAGCCATCAGAAGACATGGAATCCAATACCTTTTTTGACCCCCGAGTCTCCATTGCCCCTTC CCAGCGCCAGAGACGCACTTTTAAATTCCATGACAAGGGCAAATTTGAGAAGATTGCTCAGCGATTACGGACAAAGGCTCAACTGGAGAA GCTACAGGCAGAGATTTCACAAGCAGCTCGAAAAACAGGCATCCATACTTCGACTAGGCTTGCCCTCATTGCTCCTAAGAAGGAGCTAAA GGAAGGAGATATTCCTGAAATTGAGTGGTGGGACTCTTACATAATCCCCAATGGCTTTGATCTTACAGAGGAAAATCCCAAGAGAGAAGA TTATTTTGGAATCACAAATCTTGTTGAACATCCAGCCCAGCTCAATCCTCCAGTTGACAATGACACACCAGTTACTCTGGGAGTATATCT TACCAAGAAGGAACAGAAAAAACTTCGGAGACAAACAAGGAGGGAAGCACAGAAGGAACTACAAGAAAAAGTCAGGCTGGGCCTGATGCC TCCTCCAGAACCCAAAGTGAGAATTTCTAATTTGATGCGAGTATTAGGAACAGAAGCTGTTCAAGACCCCACGAAGGTAGAAGCCCACGT CAGAGCTCAGATGGCAAAAAGACAGAAAGCGCATGAAGAGGCCAACGCTGCCCGAAAACTCACAGCAGAACAGAGAAAGGTCAAGAAAAT TAAAAAGCTTAAAGAAGACATTTCACAGGGGGTACACATATCTGTATATAGAGTTCGAAATTTGAGCAACCCAGCCAAGAAGTTCAAGAT TGAAGCCAATGCTGGGCAACTGTACCTGACAGGGGTGGTGGTACTGCACAAGGATGTCAACGTGGTAGTAGTGGAAGGGGGCCCCAAGGC CCAGAAGAAATTTAAGCGTCTTATGCTGCATCGGATAAAGTGGGATGAACAGACATCTAACACAAAGGGAGATGGAAAGAATTGGGATGT GAATGCCGCCCTCAGTGATTTTGAACAGCTACGTCAAGTCCATGCTGGAAACCTACCCCCATCCTTTAGTGAGGGGAGTGGTGGCTCCAG GACCCCTGAAAAAGGGTTTTCTGACAGAGAGCCTACTCGCCCTCCCCGACCCATCCTCCAGCGGCAGGATGACATCGTTCAAGAAAAACG CCTGTCTAGGGGCATCTCCCACGCCAGCTCCAGCATTGTTTCCCTGGCCCGGTCCCATGTCTCCTCCAATGGTGGGGGTGGGGGGAGCAA TGAGCACCCCCTGGAAATGCCCATCTGTGCCTTCCAGCTTCCAGATCTCACTGTATACAATGAAGACTTCCGCAGCTTCATAGAGAGAGA CCTCATTGAGCAGTCCATGCTGGTTGCCTTGGAACAGGCAGGGCGTTTGAACTGGTGGGTGAGTGTGGATCCCACCTCTCAGAGGCTGCT TCCTTTGGCAACTACTGGAGATGGGAACTGCCTCCTGCATGCAGCCTCCCTTGGAATGTGGGGTTTCCATGATCGGGACTTGATGCTGCG GAAAGCTTTGTATGCACTGATGGAGAAGGGAGTTGAGAAGGAAGCGTTGAAAAGGCGCTGGAGGTGGCAGCAGACACAGCAGAATAAAGA GTCAGGGCTGGTATACACAGAAGATGAATGGCAGAAGGAGTGGAATGAACTGATCAAGCTTGCCTCAAGTGAACCCCGAATGCATCTAGG TACCAATGGAGCCAACTGTGGTGGGGTGGAGAGTTCTGAGGAGCCTGTATATGAGAGCCTTGAAGAGTTTCACGTCTTTGTCCTTGCTCA TGTGCTTAGGAGGCCCATAGTCGTCGTGGCAGACACCATGCTGAGGGACTCCGGAGGGGAAGCATTTGCCCCTATTCCCTTTGGAGGAAT CTATCTGCCTTTGGAGGTCCCAGCCAGCCAGTGTCACCGCTCCCCTCTGGTGCTCGCCTATGATCAGGCCCACTTTTCTGCACTCGTGTC CATGGAGCAGAAGGAGAATACCAAGGAACAAGCTGTGATCCCACTTACAGATTCAGAGTATAAGCTGCTGCCCTTGCACTTTGCTGTGGA CCCTGGAAAGGGCTGGGAGTGGGGCAAAGATGATAGTGACAATGTCCGATTGGCCAGTGTAATTCTGTCCCTAGAGGTCAAATTGCATCT GCTGCATAGCTACATGAATGTGAAGTGGATCCCACTGTCCTCTGATGCACAGGCTCCTCTGGCCCAGCCTGAGTCCCCCACCGCCTCAGC TGGAGATGAGCCCCGGTCCACTCCTGAGTCTGGAGACTCAGACAAGGAGTCAGTTGGCAGCAGTTCCACCAGCAACGAGGGCGGCCGGCG GAAGGAGAAGTCAAAGCGAGATCGGGAGAAGGACAAGAAGAGAGCAGATTCTGTGGCTAACAAACTGGGCAGCTTTGGCAAAACCTTGGG CAGCAAGCTCAAGAAGAACATGGGGGGCCTGATGCACAGCAAGGGTTCAAAGCCTGGAGGGGTGGGGACAGGGTTGGGAGGAAGCAGCGG CACTGAGACACTGGAGAAGAAGAAGAAAAACTCACTGAAGAGCTGGAAGGGTGGCAAGGAGGAGGCAGCTGGGGATGGGCCTGTGTCTGA GAAGCCCCCAGCTGAGTCTGTTGGTAACGGAGGGAGCAAGTATAGCCAGGAGGTGATGCAGAGCCTGAGCATTCTGAGGACTGCCATGCA AGGGGAGGGGAAGTTTATTTTTGTTGGAACCCTGAAGATGGGTCACCGTCACCAGTATCAGGAGGAAATGATCCAGCGCTACCTTTCTGA TGCTGAGGAGAGATTCCTGGCAGAACAGAAGCAGAAGGAGGCAGAGAGGAAGATCATGAATGGAGGAATAGGGGGTGGCCCTCCTCCAGC CAAAAAGCCAGAGCCAGATGCTAGGGAAGAGCAGCCGACCGGTCCCCCAGCAGAGTCCAGGGCAATGGCATTTTCCACTGGCTACCCTGG GGACTTTACTATCCCTCGGCCGTCTGGGGGCGGAGTCCACTGCCAGGAACCCCGGAGGCAGTTGGCAGGGGGTCCATGTGTCGGGGGCCT ACCACCATATGCCACCTTCCCCAGACAGTGCCCTCCTGGGCGACCCTACCCCCACCAGGACAGCATCCCTTCTCTGGAGCCAGGCAGCCA CTCTAAGGATGGACTTCACAGGGGTGCCTTGTTACCACCCCCCTACCGAGTGGCTGATTCCTATAGCAATGGCTACAGAGAGCCCCCTGA GCCAGATGGATGGGCTGGAGGTCTCCGGGGCCTTCCCCCAACTCAGACCAAATGCAAACAACCGAACTGCAGCTTCTATGGACACCCTGA GACAAACAACTTCTGTTCCTGTTGTTACAGGGAAGAACTGAGGAGGAGGGAGCGGGAACCGGATGGGGAGCTCCTGGTGCACAGGTTCTG AACGGGTGGAACACTGAAGGGCAAGGAGGCTAAACAAAGTTAAGCTCAACTAATTGGCTCATCAAGAACACAGTCCCCATGTTGAGGGGG AAAATGCAGTAATGTTTGTGGGAGCCTGGCTGGAAACTTTTAAGTGTGTGCACACAGGAGTGCTGCCAGGCTGGCAAGAGCAGGTCGGGG CTGGATGGCACCTCAGGGGCTGTACTATTCCTCTGCAGAGCTTGACTTGATGAGGTTTGAGGTACAAGGGGAAAAGATGGCGATTCTGTC TTATAACCTCCTGGGTCCCATCCAGGGACCTAAGAGAAAGTAGCAGGGGAAGGTTTGGTGTGTGGGGGTGGGAGGTGGGCAGAAGTCTTG GGGAGGAATGGGCAAAGGAGGTTCTCAGTCAATAAAACCAAAGTTCTTTAGGTTGGGAAAAAGCACATGGTGGAGTGAGAAGTGTGGAGG GGAAGTGGGAAATTGGACACATTTGCTATTGATTTGAATTAAGCTAGAAATTAAGGTTGGATAAATTCTTCCCCTTGAAGGATCTGGAAA GACAAGGCAGTAATGTGTCCTCATGGGTGCCTGTTAGGAGGTGGGGGTAGTTTAAATCCGTTTGTTTAGATGGGAAAGGGAGGAACTTAA GAGGGAAATCCTTTTCCTCTTAAGGTTTATTTCCTTCCAAGCAGTCATATGTCATCTGTTACAGTTTGAGAAGAGATTGCTGATTACCCC CTGTCTTTTCCTCATCTAAGTCTTTAATTGTATTTGTTTAAAGGGAAGAGTGTGGTGAGAACAGCCGTCATGTGTGTTGCATTTTCTCCA GGTGAATTGGGGCAGAGCTGATCTATTTTTTAACCACAGCAATAACCATACGTTGGGGTTTGAGTGCACCTTGGGAGGGGTGGGAGGACA GACATTTTAGCCAGAGGCTGTTTCAAACAAAACCAAAAACCTAAGTAGAGCATTACAGGCCTCTGTGGCTGCTGCGTTTCTGTAGAAAGC AACTTATTTTATTGACTTTTTTTTTTAAGGAAAAGAAATAAAAAGACCCCAGCAAGCAAAAACATTTAAAAAATGATTTTTTTCCCTCCT ACTTAAGTGGTTCTTTCTCCCTTTGCTCTACTTTTGGAGAATGAACTTAACATCCCGGCTTCTTTTGTTAAGCCATAGCTGACCTTAATC TGTGGTTAGTTTATTAAAATAATTAAAAATACTTTCTAAGAAGAGATATTTTTGATATTAGGACTGATGTTGAAACATATAGGGGCAATT TATAAAAAGGTAGTTAGAGAAATATATTTTAGTGAACTATAACCACAGAGCACAGATGACTCCCAATGAGCTGATCTGTCTTTAGGTTTC TCCCTTTCCCTGACCCTTCCCTGTTCTCTAGGGGCTGGGAGTGGGGATGCGGACACAGTAGGGGGAGCTCCTTCGCATTTTGCACAAAGC ACAAGTCTGAACAGCCTATGCTCTGGCCAGAGCCATTTCTAAGAGCTTTAAACCGGAAGACCTATCCTGGGCCAATTTTCCTTTTTCTTT ATATTTTTTTCCGGGAAAAAAAGTCAACTATGCAATTGTATACACTCCCGGGTGCATGTGAAGAAGGGGAATAAGTGTACTTATGTGTCC AGAGTATTAACTGGGGCTGTTTTTCTGTGTTTGGATTTCTCTTTTGAGGTATGTACTCATAACCCATCCCTTGGAACGTAATCCCCACAT TTGATCTAAAGCACTTGAGCGTGCATGCATGTGCGTGCGTGCATATGTGTGTGTGTTTTCCTCCTCGGTAGCCAGTCAAGATTGTCCTTG TTGGAAATGCTCACGGTTTATAAAGGTTATTTTCTCCTCAACAAACTCAGAAGTCACCTATTTTCCAAATCTGATTTAATAATTTCCTAT GGCTATTAATTCTTAGGGTTTTCTTTGAAAATAGATTTGTGTTAAGGAAGCAGTGAGATTCCAAAGGAAGGGATGTGTATATGTCTAGGC AGGTCTGGAACCTGGTATGAGATGAGCACTCCCCTAAGTTGCAAAATTTAAGGGTTACTATAAAACTCATTAATCAAGATACTATAAAAA ATGCAGTATTTAAAAAAATTAATGCAAAAAATTTATGTTGGATAAAATAGCGAAATCTTACAGGATCTGACAGGACTGAGATTAGGAGGA GGGAAGTGAGGCTGAATTGAATAAGTATGGGGATGAATCCTTCTTATTTAAATTTTTGATACATTGTCCATCATAGACTTTTTACATTAA TTGTGATTTTTTAAAAATGTTGCATTAAAATAGTATTTATCTTGGTTACTGGGTTTTTTGGCACTCCTTAAATTTTGTGCCCAAGGTGAG TGCTTTGCTCACCTCACCCTAGTTACGTCCCTGTTTCTGTGATTTGAACACTAGCGAGAACACCACTGTGTGCGCCTCCACCCCCATCAC ACACCAAACAACAGGTGGCTCAGACACCCTGAATTTGCACAGCTCACCTAGCTTTCCTAATTTAGGCCTTCATATCATAGAATGGTGGCC TGGACCAATAGGAATGAAAACAGACCAGGGGTTTTCCCAGAGAATAAAGCCGGAAAAGTTTTGATTCTCCACTGGACTGCTGTGTTTGGA TTTGATCTGTTGTTAGATTCTAGTTAACACTTTTGTTTTTAAAAACTAAGGACAAATGAACAAAAAACCTTGTATCATGTTTGTTTTTAT TTATAAGTTAGCCAATCCCAATTCCGTTTGCTTTATTTTCAAATAAAAAAAGATGGAAATTTTGAGGGGTGGTCTAGGGGTGAATATGGT AAAATGGGGCTTTAGGCCTTATAGCTTTTTATTAAGAAATAAATTATTTTTTTTATTTGGGAGGGTAACTATTTATTGAGGCATTGAAAA ACCTCTCCATTCTAAGGATGAGAGACCCTGAGACAATGGATATTTTTTATAGGAGATAGTGAAGTTTGTTTTGCTTCATTCTTTCGGGGA GGGTTTTGGTGGGATGGGGGGAGGTGAAGGAATAATGCCTGGGAAATTAATATAGATTCAGCTTGGTTTGTGGTATTTTGGGAAGATGAG GGAATAGAAGAGGCAAGCCCATGTCGTTACTGGGTTGGGGAGAAGGAAAGAAGGGGCATATGGCCTGCACTCGAAATGGGCAGAAAAATT CCTTAGTTAAGGAGGGGTGTGTGAGTGAAGGGGGAAGGTAGACCCTTTAACCCCAAGTGAGGGATGATATCATCTCTCAGGCTTAAATTT AAGTGCACTTAGTTCCTTTAATCCAGGGCAACTGGGGTACCTACTGAAGTTTTTAATGGAGAGGGGAGATTTTCAGGGTTCTTGTTTTTC CCTTTTTGATGTTAGACAGTGCTACTCCCTCCCTGCTGTGCTCTCTGCCCCATCTCCAATGGAGTAAGTATTACTGTAGGATAGGCCTCC GCTTCTCCCTTAACCTATGCTGCATTTATTGAAAGTTACAAGATTTAACCAGAAGTTTTTCCTCCATACTGGTTTTTATCAACAAAATAA AAAGATTATATCCAAAGATTTTTTAAAGATTCAGTCTTTTTAAGGAGTGGAGATGGTGTTAAACTCAGTGCTGTAGAGGGCAGTGGAAGG GAAGTACCTTCCCTCTATTAGCTCAGTTTTTTTTTTTCTATCAAGCGAAACTAAGGCCCACAGACAAACAAGAATTAGCAGTGACTTCGT GTTGTATATCTGCGGGGTGATACTGAGCCCAAAAGAATAAAGCTGGTTTTGAATGTGTTCTGAGAACCTAGCTTTTGCCATTCTTAACTC CTTTTAGCCATGTGTCCAAGGTTCCAGTCACATTTTTTTTCTCAATAAAGAGTATTTCAGAGATGATTGTCTCTGAATTACTCAGACACC TCTGGACTCTGAGTCTTCTTTCTTTTTCCTTTTTCTTTCTTTCTTTTTTTTTTGGTTTGAGACGGAGTCTCGCTCAGCTGCCCAGGCTGG AGTGCAGTGGTGCAATCTCGGCTCACTCCAACCACCGTCTCCTGGGTTCAAGTGATTCTCCTGTCTCAGCCTCCCAGGTGGCTGGGATTA CAGGCACCCGCAATCATGCCCGGCTAATTTTTGTATTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGATCTTGAACTCCTGAC CTCAGGTGATCCGCCAGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGACTGGCCTCTGTGTCTTCCTTCTCCAAT GAGTCAGTGCCCCAGACATATAGCCACAGGTGAGAAGACAGAATTAGAAGCCCCTTCCCGGCCTGGAATCACCTGCACTCCAGATTTTTC TAATTTCCTTCTTTCCCTCCAGGCCTTTCAACTATAGATCTGGATGAGTCATGCAGGCATTCTGTCTCTTCTACTTTGCAGACAGCCAGT CTGCAAATCACAGGGTATTTTGCCACCATACATCAGTTGGGTAACAAAATATTACGATGTCCCCATGTAGACTTTCTCTGTGCCATCTCT TGCATTGGCCAAGTGGGTAAGGGGCAGTACAAAAGAGCAACGGAAGCTGGCTGGCAGCAGTTAAGAGGAGTAGGGGTGGGAAGGACCTTG GCCTCTTTCTGTGCTTATAACTGGATCTGTGACTCATCTTGTGAGTCACTCAGCTCCACCTCCCTCCTCCGGCTGCCCCTCCCAGCAGCC TTTACTCCTGGCACAAACCTGCAGCCAGAACAGGATTCTGAAAATGGAAAAATCTGATATAGCCCCTTGCCTCTCCACCCTTCCCTTCAT CTAGTGCTTCTACTGGGGGTGTGTGGGGTGGTGAGAGGCAGCCTTAACCCTCAGCTCCTGCCCACTCCATTCCTGGTTAAGTATTGATCC AAATCGCCCAATTCTTTTCTCCTCCTGATTTCCCCCCACCCCGCTTTTTTTTTTTTTTTTTTTTGAGACAGAGTTTCGCTCTTGTCGCCC AGGATGGAGTGCAATGGCGCGATCCCGGCTCACTGCAACCTTCGTCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGGCTCCCGAGTAGCT GGGATTACAGGAGCCTACCACCATGCCTGGCTAATTTTTTTTTTTTTTTTTTTTTTTTTTTTAGTAGAGTCGGGGGTTTCGCCATGTTGG CCAGGCTGGTCTTGAATTCCTAACCTCAGGTGATCCGTGATCCACCCACCTCAGCCTTCCAAAGTGCTGGGATTACAGGCATGAGCCACC ACACCCCTACCCCCCGATTTTTTTTCTCCGTGTTCCTCCACTGTCTCCACACCTCAAAGTGCTAAAGAATAGAATGAGGCTCTTGAATGA AGGATGGTGGTGAGAAGGAAAGTGGATAATGGGATTTAAAAGTTATGGTACACACCTCTTCCTATGCTTTTTTTTTTTTTTTTTTTTTTT TTTGCGATGGAGTCTTGCTCTGTTGCCCAGGCTGGAGCGTAGTCATTAGATCTTGGCTCACTGCAACCTCTGCTTCCTGGGTTCAAGCGA TTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTATAGGTGTGAGCCACCACGCCTGGCTAATTTTTGTATTTTCAGTAGAGATGGGGCT TCATCATGTTGGCCAGGTGGTCCTGAACTCCTGACCTCAAGTAATCTGCCTGCCTTGGCCTTCCAAAATGCTTGGGATTACAGGCGTGAG CCACTGCGCCTGGTCCCTATTTTCTTTTTACAACAGACCTTGGGAAATATTTTCTTCCCCCAAGAGGTTGAGGCCCATGGAATGCATTAG GGGCAGGTGGGGTGGTGGTGCTCTGTAGCCTTTAGGACTTCTAGAATCAGGCTTCTGGGCCACCTTCTTAGCAGGTGTATACCTCTTTGT TCCAGACTGACTTTCTGTCTCACAATATCTTCACTATTTCCACAGTTGCAGCCAAGACAGGAAACTGAAAGCTGAGGCCAGAAGGGTGGT GTACTGGGGGGAGGGGAAAATTGAGTGTCACTTTGGAAAACTGGGGCCCCCATCTAAGGATTGCTGCCTCTGTAGATTCAAAAGCAATAA >In-frame_ENST00000414970_ENST00000369135_TCGA-DX-A23U-01A_PRPF3_chr1_150318967_+_OTUD7B_chr1_149943179_length(amino acids)=1380AA_start in transcript=88_stop in transcript=4230 MALSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDKKKAADHLKPFLDDSTLRFVDKLFEAVEEGRSSRHSKSSSDRSRKRE LKIKQMMEAATRQIEERKKQLSFISPPTPQPKTPSSSQPERLPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLALKPGLIGNANM VGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATGKEIELTHRMPTLKANIRAVKREQFKQQLKEKPSEDMESNTFFDPRVSIAP SQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEGDIPEIEWWDSYIIPNGFDLTEENPKRE DYFGITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLMPPPEPKVRISNLMRVLGTEAVQDPTKVEAH VRAQMAKRQKAHEEANAARKLTAEQRKVKKIKKLKEDISQGVHISVYRVRNLSNPAKKFKIEANAGQLYLTGVVVLHKDVNVVVVEGGPK AQKKFKRLMLHRIKWDEQTSNTKGDGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGSGGSRTPEKGFSDREPTRPPRPILQRQDDIVQEK RLSRGISHASSSIVSLARSHVSSNGGGGGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTSQRL LPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHL GTNGANCGGVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFSALV SMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQAPLAQPESPTAS AGDEPRSTPESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSKPGGVGTGLGGSS GTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLS DAEERFLAEQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEPRRQLAGGPCVGG LPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHP -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for PRPF3-OTUD7B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PRPF3-OTUD7B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PRPF3-OTUD7B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PRPF3 | C1832378 | Retinitis Pigmentosa 18 | 3 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
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