|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:PRPF38B-CMSS1 (FusionGDB2 ID:68603) |
Fusion Gene Summary for PRPF38B-CMSS1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PRPF38B-CMSS1 | Fusion gene ID: 68603 | Hgene | Tgene | Gene symbol | PRPF38B | CMSS1 | Gene ID | 55119 | 84319 |
| Gene name | pre-mRNA processing factor 38B | cms1 ribosomal small subunit homolog | |
| Synonyms | NET1 | C3orf26 | |
| Cytomap | 1p13.3 | 3q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pre-mRNA-splicing factor 38BPRP38 pre-mRNA processing factor 38 domain containing Bsarcoma antigen NY-SAR-27 | protein CMSS1 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q9BQ75 | |
| Ensembl transtripts involved in fusion gene | ENST00000370025, ENST00000370022, ENST00000467302, ENST00000370021, | ENST00000421999, ENST00000496116, ENST00000489081, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 11 X 9 X 9=891 |
| # samples | 1 | 13 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(13/891*10)=-2.77691380849347 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PRPF38B [Title/Abstract] AND CMSS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | PRPF38B(109242286)-CMSS1(99865815), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across PRPF38B (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across CMSS1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | BE739253 | PRPF38B | chr1 | 109242286 | + | CMSS1 | chr3 | 99865815 | + |
Top |
Fusion Gene ORF analysis for PRPF38B-CMSS1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000370025 | ENST00000421999 | PRPF38B | chr1 | 109242286 | + | CMSS1 | chr3 | 99865815 | + |
| 5CDS-intron | ENST00000370025 | ENST00000496116 | PRPF38B | chr1 | 109242286 | + | CMSS1 | chr3 | 99865815 | + |
| 5CDS-intron | ENST00000370025 | ENST00000489081 | PRPF38B | chr1 | 109242286 | + | CMSS1 | chr3 | 99865815 | + |
| intron-3CDS | ENST00000370022 | ENST00000421999 | PRPF38B | chr1 | 109242286 | + | CMSS1 | chr3 | 99865815 | + |
| intron-intron | ENST00000370022 | ENST00000496116 | PRPF38B | chr1 | 109242286 | + | CMSS1 | chr3 | 99865815 | + |
| intron-intron | ENST00000370022 | ENST00000489081 | PRPF38B | chr1 | 109242286 | + | CMSS1 | chr3 | 99865815 | + |
| intron-3CDS | ENST00000467302 | ENST00000421999 | PRPF38B | chr1 | 109242286 | + | CMSS1 | chr3 | 99865815 | + |
| intron-intron | ENST00000467302 | ENST00000496116 | PRPF38B | chr1 | 109242286 | + | CMSS1 | chr3 | 99865815 | + |
| intron-intron | ENST00000467302 | ENST00000489081 | PRPF38B | chr1 | 109242286 | + | CMSS1 | chr3 | 99865815 | + |
| In-frame | ENST00000370021 | ENST00000421999 | PRPF38B | chr1 | 109242286 | + | CMSS1 | chr3 | 99865815 | + |
| 5CDS-intron | ENST00000370021 | ENST00000496116 | PRPF38B | chr1 | 109242286 | + | CMSS1 | chr3 | 99865815 | + |
| 5CDS-intron | ENST00000370021 | ENST00000489081 | PRPF38B | chr1 | 109242286 | + | CMSS1 | chr3 | 99865815 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000370025 | PRPF38B | chr1 | 109242286 | + | ENST00000421999 | CMSS1 | chr3 | 99865815 | + | 4181 | 3190 | 32 | 1078 | 348 |
| ENST00000370021 | PRPF38B | chr1 | 109242286 | + | ENST00000421999 | CMSS1 | chr3 | 99865815 | + | 4216 | 3225 | 3263 | 4000 | 245 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000370025 | ENST00000421999 | PRPF38B | chr1 | 109242286 | + | CMSS1 | chr3 | 99865815 | + | 0.001004473 | 0.9989955 |
| ENST00000370021 | ENST00000421999 | PRPF38B | chr1 | 109242286 | + | CMSS1 | chr3 | 99865815 | + | 0.001653039 | 0.9983469 |
Top |
Fusion Genomic Features for PRPF38B-CMSS1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for PRPF38B-CMSS1 |
| Go to FGviewer for the breakpoints of chr1:109242286-chr3:99865815 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | CMSS1 |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PRPF38B | chr1:109242286 | chr3:99865815 | ENST00000370022 | + | 1 | 5 | 292_321 | 0 | 191.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | PRPF38B | chr1:109242286 | chr3:99865815 | ENST00000370025 | + | 1 | 6 | 292_321 | 0 | 547.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | PRPF38B | chr1:109242286 | chr3:99865815 | ENST00000370022 | + | 1 | 5 | 253_451 | 0 | 191.0 | Compositional bias | Note=Arg-rich |
| Hgene | PRPF38B | chr1:109242286 | chr3:99865815 | ENST00000370025 | + | 1 | 6 | 253_451 | 0 | 547.0 | Compositional bias | Note=Arg-rich |
Top |
Fusion Gene Sequence for PRPF38B-CMSS1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000370025_ENST00000421999_BE739253_PRPF38B_chr1_109242286_+_CMSS1_chr3_99865815_length(transcript)=4181nt_BP=3190nt GGGCAGTTGGCGGAAGAGATCGAGCTCCCTGGCTGCCGGCTCGCCTTCTGCGTGGAGTTCTCGCGGTCTGGGTTTCGCTGTCTGCTCTTG GCCCGGGGTCATTTTGTCGGCGTCGGGTGCCCTCTCTTGCCCAGCTGGGGCACAGCGAGGCGGCCCCTTCTCCCGACGACGTTCGATGGA GTAGGGTCCCAGACCGTTGTCCCGAAGAGCGAGATCGAGCTTGGCCCCCTCCCCCCCCTCCTTCCCTCCCTCCTTCCTTCCGCCGCAACA TGGCTAACAACAGCCCCGCGCTGACAGGCAACTCGCAGCCGCAGCACCAGGCGGCTGCAGCTGCGGCTCAGCAACAGCAGCAGTGCGGCG GCGGCGGCGCTACCAAGCCGGCGGTCTCCGGCAAGCAGGGCAATGTGCTCCCGCTCTGGGGCAACGAGAAGACCATGAACCTCAACCCCA TGATCCTGACCAACATCCTGTCGTCGCCTTACTTCAAAGTACAGCTCTACGAGCTCAAGACCTACCACGAGGTGGTGGACGAGATCTACT TTAAGGTCACGCACGTTGAACCATGGGAGAAAGGAAGCAGGAAAACAGCGGGCCAGACAGGGATGTGCGGAGGGGTTCGAGGTGTTGGAA CAGGAGGAATTGTTTCTACAGCATTTTGCCTGTTATACAAATTATTTACCCTGAAGTTAACTCGAAAGCAAGTGATGGGTCTTATAACAC ACACAGACTCTCCATATATTAGAGCGCTTGGATTTATGTATATAAGATATACACAGCCCCCTACAGATCTGTGGGACTGGTTTGAATCCT TCCTTGATGATGAAGAGGACCTAGATGTGAAGGCTGGTGGAGGCTGTGTAATGACCATTGGAGAAATGCTACGATCTTTTCTCACAAAAC TGGAGTGGTTTTCTACCTTGTTTCCAAGAATTCCAGTTCCAGTTCAAAAGAATATTGATCAACAGATTAAAACCCGACCTAGAAAAATCA AGAAAGATGGGAAGGAAGGTGCTGAGGAAATAGACAGACATGTTGAACGCAGACGTTCAAGGAAGCAGAGAAAGGAAACACAGAAGTAGG AGTCGAAGTAGAAATGCAGGGAAACGAAGTAGAAGTAGAAGCAAAGAGAAATCAAGTAAACATAAAAATGAAAGTAAAGAAAAATCAAAT AAACGAAGTCGAAGTGGCAGTCAAGGAAGAACTGACAGTGTTGAAAAATCAAAAAAACGGGAACATAGTCCCAGCAAAGAAAAATCTAGA AAGCGTAGTAGAAGCAAAGAACGTTCCCACAAACGAGATCACAGTGATAGTAAGGACCAGTCAGACAAACATGATCGTCGAAGGAGCCAA AGTATAGAACAAGAGAGCCAAGAAAAACAGCATAAAAACAAAGATGAGACTGTGTGAAAATATTTTGTAAAAGTGGATCACATTGAATCC TATAAATGATTAAATCTGCTTTTTTCCCCCACGTTGAGATTGTGCAGTAGTTCGCACTCCTCAAGCTCTCCCTGTAGGCTGCATTTTCAT TTCCTCTTTCGTGTAGGGAAGTGCCTTTGTAATTCCATTTATTGCATTGGTGTTTTCACCCAATTGTTAAGTTTGATACATGATGCACAG ATTGTTCTTGCATTTTTATTGTTTGTTTTTGAAATGTACAGTCTGTACATATGTCCTGAAAATGTTTTAATTCCTTTGGCATGGTTGCCA TGTTGGTTAAATTTGTATAAGGCAATAAACTGCCACTAATCTATTTTTGTTTTGTAGGTGTGGGATTATGGTTTGTGTACTGAAGTTAGC ATGGCTGTGCTTTTCGTAATAGAATGCTAAAGACTTTGAGAATGGATCTTGGATGTCTATTATAGGAGAAGTATGTGCTGCCAATGTACA AGAAGGCAGCATTGTAGGATTAACATTCTTGTCTACTGTATATTATCTTGGAAGGCTCTTGTTAATATGTTACACTTAATATTCTCCACA GTTACCTTTAGAGAGAATTTATGAGAAGTTAGTTTCTGATGCAGAGGTTTTTAGGCTGTGATTTCATCAAAAGTCCTTTTAGCATTCTAC CTCAAAGGGACACTTAGTATGCCTAAAATTTATTCACTTAGTTTTCCTTTTTTATTTGAAAAAATACATGACATGTAATCTTTTTTTCTT GAATTCTTTCTCAGATTTTAAAGTACTATATTAAAGAAAAAAATTAATGTCTAAAGCCTAGCATTCTTGCAGAACCCTATACTAACATGT AATGGGGAGAGGGTGGGGCAGATGAGTAGAGAAACAGATTCAAGCCTCAAGCTTCCAAAGCATTTTTATAAATGGAAAATCCTTAAATTA TGAAACAGCTTGATATAGTGTCCTTTTTTTAAAATTCAGAACTTTTTTTATTGATAATGGAGATTGCTGTTTGAGTTTTTAAACTTAATC TAGAACAGAGGAGTATTAAAAGTAATGCTGTGCTGCATTATTTAAGACTATCAGCAAATTATTTGATAGATTGTTCTTACAACTTGTATT CTGATTACAGAACCATCATGAGTGTGGAATAAATACTGGATTAAATCCTTTATCCTGGGTCTTGGCTTTTCCCCCATTTGTTAAATTTTT TTAGCATATTTATATTGTGGAAATTGATGAAACGTCAGTAGAGTCACACTTTGTGTACAGGGATGTCTTAGTGCCCAGATGACAAGTGAA TTTTGGAGAAATGCATAGACTGGGATTGGGCATGTGGTAATCAATAATCTTTATTAGAATACTTGATAATGGCAGTTCCCTTTGTCAGTG GTTGTTACATGTGTCATTTGATTACTTTGTTCCATGTCAAAGACGTTTATTGGGATACCTTTTACTTGGACAATATGTTAGCATTTTTTA AAATTTGGACTTGAAATTCTTTAAGATAATTCACCCAATTCTTTTTAGAAAAGAAAATAGAGGCCCAAAGTAATGATGTCAGTGCTAGGG CTAAAACTCAGTATTCTGACAGTGTAGTGAACCTGGCACGCACATTGAGGTTTGTTTTATCTCACTGGTTATACTGGCCAACTAATGCGC ACTCAGAAGCCACCTTGCAAAAATGTTAAATGGAGCAAACGAGTACACTTGCAAGAGTCCTCCATATGTGGGCTTAACATATGTACCACT CCATTTTAGAAAAATCTCATTAAATGAATTCTTCTAAAAAAAGCATCAGATGGTGAAGGAGAAGGAGACACAGAAGTGATGCAGCAGGAG ACAGTTCCAGTTCCTGTACCTTCAGAGAAAACCAAACAGCCTAAAGAATGTTTTTTGATACAACCAAAGGAAAGAAAAGAGAATACCACC AAGACCAGGAAAAGAAGAAAGAAGAAAATTACTGATGTTCTTGCAAAATCAGAACCAAAACCAGGGTTACCTGAAGACCTACAGAAGCTG ATGAAGGACTATTATAGCAGCAGACGCTTGGTGATTGAATTAGAAGAACTGAACCTGCCAGACTCCTGTTTCCTCAAGGCCAATGATTTG ACTCACAGTCTTTCCTCATACCTAAAAGAAATTTGTCCTAAGTGGGTAAAACTTAGGAAGAACCACAGTGAGAAGAAATCGGTCCTGATG CTGATCATCTGCAGCTCGGCCGTCCGAGCCCTGGAGCTCATTAGGTCGATGACAGCATTCAGAGGAGACGGCAAAGTTATAAAATTATTT GCAAAGCACATAAAGGTCCAGGCGCAGGTAAAGTTGCTGGAGAAGCGTGTGGTGCACCTGGGTGTAGGAACTCCGGGGAGAATTAAAGAA CTTGTTAAACAAGGTGGCCTTAATTTGAGCCCCTTAAAATTTCTGGTTTTTGACTGGAACTGGAGAGATCAGAAGTTGAGGAGAATGATG GACATTCCCGAGATAAGAAAGGAGGTATTCGAACTTCTGGAAATGGGAGTGCTCAGTCTGTGCAAGTCAGAATCCTTGAAACTGGGCCTT TTCTAAGTCTGTGTCCTAATGAAGATTCCAGTTTTCACAGTAGAAGTTGCATCTTATTTAATGACTCTGATACATTGCAAGCACTCAGTA AATATCAGCAAATAGTTTATGTTAATTGTGTCAACAGATGGATCACTGGAATGTGGGGATTCTGAAACAGAAATGAAACTGTCCTTTTGA >In-frame_ENST00000370025_ENST00000421999_BE739253_PRPF38B_chr1_109242286_+_CMSS1_chr3_99865815_length(amino acids)=348AA_start in transcript=32_stop in transcript=1078 MPARLLRGVLAVWVSLSALGPGSFCRRRVPSLAQLGHSEAAPSPDDVRWSRVPDRCPEERDRAWPPPPPPSLPPSFRRNMANNSPALTGN SQPQHQAAAAAAQQQQQCGGGGATKPAVSGKQGNVLPLWGNEKTMNLNPMILTNILSSPYFKVQLYELKTYHEVVDEIYFKVTHVEPWEK GSRKTAGQTGMCGGVRGVGTGGIVSTAFCLLYKLFTLKLTRKQVMGLITHTDSPYIRALGFMYIRYTQPPTDLWDWFESFLDDEEDLDVK -------------------------------------------------------------- >In-frame_ENST00000370021_ENST00000421999_BE739253_PRPF38B_chr1_109242286_+_CMSS1_chr3_99865815_length(transcript)=4216nt_BP=3225nt ATCGAGCTCCCTGGCTGCCGGCTCGCCTTCTGCGTGGAGTTCTCGCGGTCTGGGTTTCGCTGTCTGCTCTTGGCCCGGGGTCATTTTGTC GGCGTCGGGTGCCCTCTCTTGCCCAGCTGGGGCACAGCGAGGCGGCCCCTTCTCCCGACGACGTTCGATGGAGTAGGGTCCCAGACCGTT GTCCCGAAGAGCGAGATCGAGCTTGGCCCCCTCCCCCCCCTCCTTCCCTCCCTCCTTCCTTCCGCCGCAACATGGCTAACAACAGCCCCG CGCTGACAGGCAACTCGCAGCCGCAGCACCAGGCGGCTGCAGCTGCGGCTCAGCAACAGCAGCAGTGCGGCGGCGGCGGCGCTACCAAGC CGGCGGTCTCCGGCAAGCAGGGCAATGTGCTCCCGCTCTGGGGCAACGAGAAGACCATGAACCTCAACCCCATGATCCTGACCAACATCC TGTCGTCGCCTTACTTCAAAGTACAGCTCTACGAGCTCAAGACCTACCACGAGGTGGTGGACGAGATCTACTTTAAGGATTGACTCAGTC TTGCAGCGAGGCTCGGAGCAGCCCAGGGTCGCAGGTAGAGGTCACGCACGTTGAACCATGGGAGAAAGGAAGCAGGAAAACAGCGGGCCA GACAGGGATGTGCGGAGGGGTTCGAGGTGTTGGAACAGGAGGAATTGTTTCTACAGCATTTTGCCTGTTATACAAATTATTTACCCTGAA GTTAACTCGAAAGCAAGTGATGGGTCTTATAACACACACAGACTCTCCATATATTAGAGCGCTTGGATTTATGTATATAAGATATACACA GCCCCCTACAGATCTGTGGGACTGGTTTGAATCCTTCCTTGATGATGAAGAGGACCTAGATGTGAAGGCTGGTGGAGGCTGTGTAATGAC CATTGGAGAAATGCTACGATCTTTTCTCACAAAACTGGAGTGGTTTTCTACCTTGTTTCCAAGAATTCCAGTTCCAGTTCAAAAGAATAT TGATCAACAGATTAAAACCCGACCTAGAAAAATCAAGAAAGATGGGAAGGAAGGTGCTGAGGAAATAGACAGACATGTTGAACGCAGACG TTCAAGGAAGCAGAGAAAGGAAACACAGAAGTAGGAGTCGAAGTAGAAATGCAGGGAAACGAAGTAGAAGTAGAAGCAAAGAGAAATCAA GTAAACATAAAAATGAAAGTAAAGAAAAATCAAATAAACGAAGTCGAAGTGGCAGTCAAGGAAGAACTGACAGTGTTGAAAAATCAAAAA AACGGGAACATAGTCCCAGCAAAGAAAAATCTAGAAAGCGTAGTAGAAGCAAAGAACGTTCCCACAAACGAGATCACAGTGATAGTAAGG ACCAGTCAGACAAACATGATCGTCGAAGGAGCCAAAGTATAGAACAAGAGAGCCAAGAAAAACAGCATAAAAACAAAGATGAGACTGTGT GAAAATATTTTGTAAAAGTGGATCACATTGAATCCTATAAATGATTAAATCTGCTTTTTTCCCCCACGTTGAGATTGTGCAGTAGTTCGC ACTCCTCAAGCTCTCCCTGTAGGCTGCATTTTCATTTCCTCTTTCGTGTAGGGAAGTGCCTTTGTAATTCCATTTATTGCATTGGTGTTT TCACCCAATTGTTAAGTTTGATACATGATGCACAGATTGTTCTTGCATTTTTATTGTTTGTTTTTGAAATGTACAGTCTGTACATATGTC CTGAAAATGTTTTAATTCCTTTGGCATGGTTGCCATGTTGGTTAAATTTGTATAAGGCAATAAACTGCCACTAATCTATTTTTGTTTTGT AGGTGTGGGATTATGGTTTGTGTACTGAAGTTAGCATGGCTGTGCTTTTCGTAATAGAATGCTAAAGACTTTGAGAATGGATCTTGGATG TCTATTATAGGAGAAGTATGTGCTGCCAATGTACAAGAAGGCAGCATTGTAGGATTAACATTCTTGTCTACTGTATATTATCTTGGAAGG CTCTTGTTAATATGTTACACTTAATATTCTCCACAGTTACCTTTAGAGAGAATTTATGAGAAGTTAGTTTCTGATGCAGAGGTTTTTAGG CTGTGATTTCATCAAAAGTCCTTTTAGCATTCTACCTCAAAGGGACACTTAGTATGCCTAAAATTTATTCACTTAGTTTTCCTTTTTTAT TTGAAAAAATACATGACATGTAATCTTTTTTTCTTGAATTCTTTCTCAGATTTTAAAGTACTATATTAAAGAAAAAAATTAATGTCTAAA GCCTAGCATTCTTGCAGAACCCTATACTAACATGTAATGGGGAGAGGGTGGGGCAGATGAGTAGAGAAACAGATTCAAGCCTCAAGCTTC CAAAGCATTTTTATAAATGGAAAATCCTTAAATTATGAAACAGCTTGATATAGTGTCCTTTTTTTAAAATTCAGAACTTTTTTTATTGAT AATGGAGATTGCTGTTTGAGTTTTTAAACTTAATCTAGAACAGAGGAGTATTAAAAGTAATGCTGTGCTGCATTATTTAAGACTATCAGC AAATTATTTGATAGATTGTTCTTACAACTTGTATTCTGATTACAGAACCATCATGAGTGTGGAATAAATACTGGATTAAATCCTTTATCC TGGGTCTTGGCTTTTCCCCCATTTGTTAAATTTTTTTAGCATATTTATATTGTGGAAATTGATGAAACGTCAGTAGAGTCACACTTTGTG TACAGGGATGTCTTAGTGCCCAGATGACAAGTGAATTTTGGAGAAATGCATAGACTGGGATTGGGCATGTGGTAATCAATAATCTTTATT AGAATACTTGATAATGGCAGTTCCCTTTGTCAGTGGTTGTTACATGTGTCATTTGATTACTTTGTTCCATGTCAAAGACGTTTATTGGGA TACCTTTTACTTGGACAATATGTTAGCATTTTTTAAAATTTGGACTTGAAATTCTTTAAGATAATTCACCCAATTCTTTTTAGAAAAGAA AATAGAGGCCCAAAGTAATGATGTCAGTGCTAGGGCTAAAACTCAGTATTCTGACAGTGTAGTGAACCTGGCACGCACATTGAGGTTTGT TTTATCTCACTGGTTATACTGGCCAACTAATGCGCACTCAGAAGCCACCTTGCAAAAATGTTAAATGGAGCAAACGAGTACACTTGCAAG AGTCCTCCATATGTGGGCTTAACATATGTACCACTCCATTTTAGAAAAATCTCATTAAATGAATTCTTCTAAAAAAAGCATCAGATGGTG AAGGAGAAGGAGACACAGAAGTGATGCAGCAGGAGACAGTTCCAGTTCCTGTACCTTCAGAGAAAACCAAACAGCCTAAAGAATGTTTTT TGATACAACCAAAGGAAAGAAAAGAGAATACCACCAAGACCAGGAAAAGAAGAAAGAAGAAAATTACTGATGTTCTTGCAAAATCAGAAC CAAAACCAGGGTTACCTGAAGACCTACAGAAGCTGATGAAGGACTATTATAGCAGCAGACGCTTGGTGATTGAATTAGAAGAACTGAACC TGCCAGACTCCTGTTTCCTCAAGGCCAATGATTTGACTCACAGTCTTTCCTCATACCTAAAAGAAATTTGTCCTAAGTGGGTAAAACTTA GGAAGAACCACAGTGAGAAGAAATCGGTCCTGATGCTGATCATCTGCAGCTCGGCCGTCCGAGCCCTGGAGCTCATTAGGTCGATGACAG CATTCAGAGGAGACGGCAAAGTTATAAAATTATTTGCAAAGCACATAAAGGTCCAGGCGCAGGTAAAGTTGCTGGAGAAGCGTGTGGTGC ACCTGGGTGTAGGAACTCCGGGGAGAATTAAAGAACTTGTTAAACAAGGTGGCCTTAATTTGAGCCCCTTAAAATTTCTGGTTTTTGACT GGAACTGGAGAGATCAGAAGTTGAGGAGAATGATGGACATTCCCGAGATAAGAAAGGAGGTATTCGAACTTCTGGAAATGGGAGTGCTCA GTCTGTGCAAGTCAGAATCCTTGAAACTGGGCCTTTTCTAAGTCTGTGTCCTAATGAAGATTCCAGTTTTCACAGTAGAAGTTGCATCTT ATTTAATGACTCTGATACATTGCAAGCACTCAGTAAATATCAGCAAATAGTTTATGTTAATTGTGTCAACAGATGGATCACTGGAATGTG >In-frame_ENST00000370021_ENST00000421999_BE739253_PRPF38B_chr1_109242286_+_CMSS1_chr3_99865815_length(amino acids)=245AA_start in transcript=3263_stop in transcript=4000 MQQETVPVPVPSEKTKQPKECFLIQPKERKENTTKTRKRRKKKITDVLAKSEPKPGLPEDLQKLMKDYYSSRRLVIELEELNLPDSCFLK ANDLTHSLSSYLKEICPKWVKLRKNHSEKKSVLMLIICSSAVRALELIRSMTAFRGDGKVIKLFAKHIKVQAQVKLLEKRVVHLGVGTPG -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for PRPF38B-CMSS1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for PRPF38B-CMSS1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for PRPF38B-CMSS1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies