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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PRPF8-RPL37A (FusionGDB2 ID:68646)

Fusion Gene Summary for PRPF8-RPL37A

check button Fusion gene summary
Fusion gene informationFusion gene name: PRPF8-RPL37A
Fusion gene ID: 68646
HgeneTgene
Gene symbol

PRPF8

RPL37A

Gene ID

10594

6168

Gene namepre-mRNA processing factor 8ribosomal protein L37a
SynonymsHPRP8|PRP8|PRPC8|RP13|SNRNP220L37A
Cytomap

17p13.3

2q35

Type of geneprotein-codingprotein-coding
Descriptionpre-mRNA-processing-splicing factor 8220 kDa U5 snRNP-specific proteinPRP8 homologPRP8 pre-mRNA processing factor 8 homologU5 snRNP-specific protein (220 kD), ortholog of S. cerevisiae Prp8papoptosis-regulated protein 1apoptosis-regulated protein 260S ribosomal protein L37alarge ribosomal subunit protein eL43
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000304992, ENST00000572621, 
ENST00000575116, 		ENST00000491306, 
ENST00000600880, ENST00000446558, 
ENST00000456586, ENST00000598925, 
ENST00000427280, ENST00000441179, 
Fusion gene scores* DoF score13 X 16 X 7=145623 X 13 X 5=1495
# samples 1626
** MAII scorelog2(16/1456*10)=-3.18586654531133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/1495*10)=-2.52356195605701
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRPF8 [Title/Abstract] AND RPL37A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPRPF8(1581811)-RPL37A(217363988), # samples:1
Anticipated loss of major functional domain due to fusion event.PRPF8-RPL37A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PRPF8-RPL37A seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PRPF8-RPL37A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRPF8

GO:0000244

spliceosomal tri-snRNP complex assembly

20595234

HgenePRPF8

GO:0000398

mRNA splicing, via spliceosome

28781166|29301961


check buttonFusion gene breakpoints across PRPF8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RPL37A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABG478185PRPF8chr17

1581811

-RPL37Achr2

217363988

+


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Fusion Gene ORF analysis for PRPF8-RPL37A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000304992ENST00000491306PRPF8chr17

1581811

-RPL37Achr2

217363988

+
Frame-shiftENST00000304992ENST00000600880PRPF8chr17

1581811

-RPL37Achr2

217363988

+
Frame-shiftENST00000304992ENST00000446558PRPF8chr17

1581811

-RPL37Achr2

217363988

+
5CDS-5UTRENST00000304992ENST00000456586PRPF8chr17

1581811

-RPL37Achr2

217363988

+
5CDS-5UTRENST00000304992ENST00000598925PRPF8chr17

1581811

-RPL37Achr2

217363988

+
5CDS-5UTRENST00000304992ENST00000427280PRPF8chr17

1581811

-RPL37Achr2

217363988

+
5CDS-5UTRENST00000304992ENST00000441179PRPF8chr17

1581811

-RPL37Achr2

217363988

+
In-frameENST00000572621ENST00000491306PRPF8chr17

1581811

-RPL37Achr2

217363988

+
In-frameENST00000572621ENST00000600880PRPF8chr17

1581811

-RPL37Achr2

217363988

+
In-frameENST00000572621ENST00000446558PRPF8chr17

1581811

-RPL37Achr2

217363988

+
5CDS-5UTRENST00000572621ENST00000456586PRPF8chr17

1581811

-RPL37Achr2

217363988

+
5CDS-5UTRENST00000572621ENST00000598925PRPF8chr17

1581811

-RPL37Achr2

217363988

+
5CDS-5UTRENST00000572621ENST00000427280PRPF8chr17

1581811

-RPL37Achr2

217363988

+
5CDS-5UTRENST00000572621ENST00000441179PRPF8chr17

1581811

-RPL37Achr2

217363988

+
intron-3CDSENST00000575116ENST00000491306PRPF8chr17

1581811

-RPL37Achr2

217363988

+
intron-3CDSENST00000575116ENST00000600880PRPF8chr17

1581811

-RPL37Achr2

217363988

+
intron-3CDSENST00000575116ENST00000446558PRPF8chr17

1581811

-RPL37Achr2

217363988

+
intron-5UTRENST00000575116ENST00000456586PRPF8chr17

1581811

-RPL37Achr2

217363988

+
intron-5UTRENST00000575116ENST00000598925PRPF8chr17

1581811

-RPL37Achr2

217363988

+
intron-5UTRENST00000575116ENST00000427280PRPF8chr17

1581811

-RPL37Achr2

217363988

+
intron-5UTRENST00000575116ENST00000441179PRPF8chr17

1581811

-RPL37Achr2

217363988

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000572621PRPF8chr171581811-ENST00000491306RPL37Achr2217363988+454321202662395709
ENST00000572621PRPF8chr171581811-ENST00000600880RPL37Achr2217363988+251721202662335689
ENST00000572621PRPF8chr171581811-ENST00000446558RPL37Achr2217363988+259221202662344692

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000572621ENST00000491306PRPF8chr171581811-RPL37Achr2217363988+0.0007835950.99921644
ENST00000572621ENST00000600880PRPF8chr171581811-RPL37Achr2217363988+0.0021838820.9978161
ENST00000572621ENST00000446558PRPF8chr171581811-RPL37Achr2217363988+0.0016057110.9983943

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Fusion Genomic Features for PRPF8-RPL37A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PRPF8chr171581811-RPL37Achr2217363992+0.701027040.298973
PRPF8chr171581811-RPL37Achr2217363992+0.701027040.298973

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PRPF8-RPL37A


check button Go to

FGviewer for the breakpoints of chr17:1581811-chr2:217363988

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRPL37Achr17:1581811chr2:217363988ENST000004913060439_601.093.0Zinc fingerNote=C4-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRPF8chr17:1581811chr2:217363988ENST00000304992-13432103_2234618.02336.0DomainMPN
HgenePRPF8chr17:1581811chr2:217363988ENST00000572621-12422103_2234618.02336.0DomainMPN
HgenePRPF8chr17:1581811chr2:217363988ENST00000304992-13431304_1577618.02336.0RegionNote=Linker
HgenePRPF8chr17:1581811chr2:217363988ENST00000304992-13431513_1526618.02336.0RegionImportant for branch point selection
HgenePRPF8chr17:1581811chr2:217363988ENST00000304992-13431581_1752618.02336.0RegionNote=Restriction endonuclease homology domain
HgenePRPF8chr17:1581811chr2:217363988ENST00000304992-13431767_2020618.02336.0RegionNote=RNase H homology domain
HgenePRPF8chr17:1581811chr2:217363988ENST00000304992-1343812_1303618.02336.0RegionNote=Reverse transcriptase homology domain
HgenePRPF8chr17:1581811chr2:217363988ENST00000572621-12421304_1577618.02336.0RegionNote=Linker
HgenePRPF8chr17:1581811chr2:217363988ENST00000572621-12421513_1526618.02336.0RegionImportant for branch point selection
HgenePRPF8chr17:1581811chr2:217363988ENST00000572621-12421581_1752618.02336.0RegionNote=Restriction endonuclease homology domain
HgenePRPF8chr17:1581811chr2:217363988ENST00000572621-12421767_2020618.02336.0RegionNote=RNase H homology domain
HgenePRPF8chr17:1581811chr2:217363988ENST00000572621-1242812_1303618.02336.0RegionNote=Reverse transcriptase homology domain


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Fusion Gene Sequence for PRPF8-RPL37A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000572621_ENST00000491306_BG478185_PRPF8_chr17_1581811_-_RPL37A_chr2_217363988_length(transcript)=4543nt_BP=2120nt
GCAGTCTGGCCGCCATTGCGCTGCGGGGAAAGCGGCCTCTTGTGTGAGGGCCTGTGGGGTGCGTGGCAGGCGTTTAAGGCCGGGCTGCGG
GAGGCGTGGTCGGGTCGGGCCGAGTGACCGAAGGGGTTAGGCCGGGCGGGGCTGGATGCACTGTGTGGCGGGACTGCAGGCCGGGGTCCC
CGGACGCCTTTCTGCTGCGCTTCTTGTGGGCCCGGGCCTGTGGTTAGTGAATTTTTCTATCCCGCCGCTCCCCAGATTCTCCGGATATGG
CCGGAGTGTTTCCTTATCGAGGGCCGGGTAACCCGGTGCCTGGCCCTCTAGCCCCGCTACCGGACTACATGTCGGAGGAGAAGCTGCAGG
AGAAAGCTCGAAAATGGCAGCAATTGCAGGCCAAGCGCTATGCAGAAAAGCGGAAGTTTGGGTTTGTGGATGCCCAGAAGGAAGACATGC
CCCCAGAACATGTCAGGAAGATCATTCGAGACCATGGAGACATGACCAACAGGAAGTTCCGCCATGACAAAAGGGTTTACTTGGGTGCCC
TAAAGTACATGCCCCACGCAGTCCTCAAACTCCTGGAGAACATGCCTATGCCTTGGGAGCAGATTCGGGATGTGCCTGTGCTGTACCACA
TCACTGGAGCCATTTCCTTCGTCAATGAGATTCCCTGGGTCATTGAACCTGTCTACATCTCCCAGTGGGGGTCAATGTGGATTATGATGC
GCCGAGAAAAAAGAGATAGGAGGCATTTCAAGAGGATGCGTTTTCCCCCTTTTGATGATGAGGAGCCGCCCTTGGACTATGCTGACAACA
TCCTAGATGTTGAGCCACTGGAGGCCATTCAGCTAGAGCTGGACCCTGAGGAGGACGCCCCTGTGTTGGACTGGTTCTATGACCACCAGC
CGTTGAGGGACAGCAGGAAGTATGTAAATGGCTCCACTTACCAGCGCTGGCAGTTCACACTACCTATGATGTCGACTCTCTACCGCCTGG
CTAATCAGCTCCTGACAGACTTGGTGGATGACAACTACTTCTACCTGTTTGATTTGAAGGCCTTCTTTACGTCCAAGGCACTCAATATGG
CCATTCCTGGAGGCCCCAAATTTGAACCTCTTGTTCGAGACATCAACCTACAGGATGAAGACTGGAATGAATTCAATGATATTAACAAGA
TTATCATCCGGCAGCCTATCCGCACTGAGTACAAGATTGCTTTTCCTTACTTGTACAACAATCTTCCACACCATGTCCACCTCACCTGGT
ACCATACTCCCAATGTTGTATTCATCAAAACTGAGGATCCTGACTTGCCAGCTTTCTACTTTGACCCTTTGATCAACCCAATCTCCCATA
GGCACTCAGTCAAGAGCCAGGAACCATTGCCGGATGATGATGAGGAATTTGAGCTCCCGGAGTTTGTGGAGCCCTTCCTGAAGGACACAC
CCCTCTATACAGACAATACAGCCAATGGCATTGCCCTGCTCTGGGCCCCGCGGCCCTTCAACCTACGCTCTGGTCGCACCCGTCGGGCCC
TGGACATACCCCTTGTCAAGAACTGGTATCGGGAGCATTGTCCTGCCGGGCAGCCTGTGAAAGTGAGGGTCTCCTACCAGAAGCTGCTTA
AGTACTATGTGCTGAATGCCCTGAAGCATCGGCCCCCTAAGGCTCAAAAGAAGAGGTATTTGTTCCGCTCCTTCAAAGCCACCAAATTCT
TTCAGTCCACAAAGCTGGACTGGGTGGAGGTTGGGCTCCAGGTTTGCCGCCAGGGCTACAACATGCTCAACCTTCTCATTCACCGCAAAA
ACCTCAACTACCTGCACCTGGACTACAACTTCAACCTCAAGCCTGTGAAAACGCTCACCACCAAGGAAAGAAAGAAATCTCGTTTTGGGA
ATGCTTTCCACCTGTGTCGGGAAGTTCTGCGTTTGACTAAGCTGGTGGTGGATAGTCACGTGCAGTATCGGCTGGGCAATGTGGATGCCT
TCCAGCTGGCAGATGGATTGCAGTATATATTTGCCCATGTTGGGCAGTTGACGGGCATGTATCGATACAAATACAAGCTGATGCGACAGA
TTCGCATGTGCAAGGACCTGAAGCATCTCATCTATTATCGTTTCAACACGGCCAAACGTACCAAGAAAGTCGGGATCGTCGGTAAATACG
GGACCCGCTATGGGGCCTCCCTCCGGAAAATGGTGAAGAAAATTGAAATCAGCCAGCACGCCAAGTACACTTGCTCTTTCTGTGGCAAAA
CCAAGATGAAGAGACGAGCTGTGGGGATCTGGCACTGTGGTTCCTGCATGAAGACAGTGGCTGGCGGTGCCTGGACGTACAATACCACTT
CCGCTGTCACGGTAAAGTCCGCCATCAGAAGACTGAAGGAGTTGAAAGACCAGTAGACGCTCCTCTACTCTTTGAGACATCACTGGCCTA
TAATAAATGGGTTAATTTATGTAACAAAATTGCCTTGGCTTGTTAACTTTATTAGACATTCTGATGTTTGCATTGTGTAAATACTGTTGT
ATTGGAAAAGCATGCCAAGATGGATTATTGTAATTCAGTGTCTTTTTTAGTAGTCAAATGGTAAAATGCAGCATAAGAATATAAGTCTTC
CAAGTTAGATATGAGTGTTAGCTTTTTATAAGTCTGCTCCTGCCAGTTTGACTTTGAGATACATTGGAGCCAACTGTAAACTTTAGTTTT
TAAATTACAGTTAGTTTTTTTGTTTGTTTTTGAGGCGGAGTCTCTGTTACCCAGGCTGGAGTGCAGTATACCAGTCTTGGCCCACTTCAA
CCTCCACTTCTTAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCACGCACCACCATACCTGGCTAATTTT
TGTATTTTGAGTAGAGATGGAGTTTTCACCACATTGGCCAGGCTGTTCTTGAACTGACCTCAAGCGATCCACCTGCCTTGGCCTTCCAGA
GTGCTGGGATTACAGGTGTGAGCCACCACGCCCAGCCTTGCATTTAATATTTTTATAATGTGTCTAGGCTGGGTGCGGTGACTCACGCCT
GAAATCCCAGCACTTTGGGTGGCTGAGGCAGGTGGATTACTTGAGGCCAGGAGATTGAGACCAGTGTGGCCAACATAGCAAAAACCCGTC
TCGACGAAAAATACAAAAAATAGCTTGGTATGGTGGCACATGCCTGTAATCCCAGCTACTTTGGAGGCTCAGGCACAAGAATCACTTGAA
CCTACGAGGCGGAGGTTGCAGTGGGCCAGGATCGTGCCACTGCACTTTATTTAGCCAGGACAACACTCTGTCTCCAAAAAAAAGTTTCTG
AAGGTAAAAGATATACTAAAGGATATACATATACTGCCTCTTCTATGATGTTTCATTTGACCTACACCATCAGCATCTTCAGGAAACAGT
ATGAAACTAATTTCACATTAAATGTTGCAAACGTCTGCAATTCTCCAGTTTTTAGTTTGCACGTAAGGATTCGTAGGATTGATTTCAGAT
TGACAGATGGTTGTAGTAACAAAAAAATGAATTGCCTTGGAGAATTCGAGTTATTTTAGGCCTGCCTTTGACACTTTTATGCACTTAATT
CACTGCCAATTTAGTCTAACTCCTCAACCATCTGTGGTATGGACTTCTCAGTCCTCCTAATTGGTATGTCTTTTATCTATCCCAGAGTCA
GTAGTCCTTTAAGGATGCAAATTTAATTCGATAAGAATGTGGATTTACTTCATCTTTAGGACAGAGTAAAAACCTTTATTTCACTTGGTC
TGACCCCTATCTTCTATAACTTGTTTTTTTGCTCATTACTGGCCTTTGCACGGATGTCTCCCTTCACCTGTACCTCCTGCATTGCCTCTG
GCAGAAACATCGCTACCCCAGGAGAATACTTCACTGGGTCAGGCATTTGCTAGATCCATAGCAGTAACTCATCTGTGGATCTCATTTGTG
TCACAAAATGGTACTCCTACTGATTTTGTAATGTGAAGCAAGTACTGTGGGTCAGTAGGGGTAGGACCAGGAGTGACAAGTCAGGATTTT
CAGGCTTCATAGGAATGACACAGCTCTCCAGGTGAATCTCCTGGAGAATTCTCCATAGGATCTCCAGGTGAGTGACCAGGATTTCATGTA
AGCATAGGGAATTGAATGAGCATTAGATGGTCTAATGCTGCGGTTAAGAACACCAACTTAGCCAAACTGCCTAGATAGTTGGGTGACTTG
GGTTAAGTGACTTAACCTCTCTGCTTCAGTTTCCTGTATAATTCTTGGTAGTAGAATGGAGTATATGCTGGGTGTTTGGATTATTAATTT
GGAGTCTTACAAAGCTGCTATGTTACATGATTAGGCATGGAAAACTTCGGTTTTTATAATCAGTGAAGTACTGCTTTTTGTTTGTTTTCT
GAGAGAGTGTCTGTCACCCAGGCTGAAGTGCAGTGGCATGATCTCAGTTCACTGCAGCCTCTACCTCCCGGGTTCAAGCAGTTCTCGTGC

>In-frame_ENST00000572621_ENST00000491306_BG478185_PRPF8_chr17_1581811_-_RPL37A_chr2_217363988_length(amino acids)=709AA_start in transcript=266_stop in transcript=2395
MAGVFPYRGPGNPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKRYAEKRKFGFVDAQKEDMPPEHVRKIIRDHGDMTNRKFRHDKRVYLG
ALKYMPHAVLKLLENMPMPWEQIRDVPVLYHITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYAD
NILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYRLANQLLTDLVDDNYFYLFDLKAFFTSKALN
MAIPGGPKFEPLVRDINLQDEDWNEFNDINKIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKTEDPDLPAFYFDPLINPIS
HRHSVKSQEPLPDDDEEFELPEFVEPFLKDTPLYTDNTANGIALLWAPRPFNLRSGRTRRALDIPLVKNWYREHCPAGQPVKVRVSYQKL
LKYYVLNALKHRPPKAQKKRYLFRSFKATKFFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRF
GNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMRQIRMCKDLKHLIYYRFNTAKRTKKVGIVGK

--------------------------------------------------------------
>In-frame_ENST00000572621_ENST00000600880_BG478185_PRPF8_chr17_1581811_-_RPL37A_chr2_217363988_length(transcript)=2517nt_BP=2120nt
GCAGTCTGGCCGCCATTGCGCTGCGGGGAAAGCGGCCTCTTGTGTGAGGGCCTGTGGGGTGCGTGGCAGGCGTTTAAGGCCGGGCTGCGG
GAGGCGTGGTCGGGTCGGGCCGAGTGACCGAAGGGGTTAGGCCGGGCGGGGCTGGATGCACTGTGTGGCGGGACTGCAGGCCGGGGTCCC
CGGACGCCTTTCTGCTGCGCTTCTTGTGGGCCCGGGCCTGTGGTTAGTGAATTTTTCTATCCCGCCGCTCCCCAGATTCTCCGGATATGG
CCGGAGTGTTTCCTTATCGAGGGCCGGGTAACCCGGTGCCTGGCCCTCTAGCCCCGCTACCGGACTACATGTCGGAGGAGAAGCTGCAGG
AGAAAGCTCGAAAATGGCAGCAATTGCAGGCCAAGCGCTATGCAGAAAAGCGGAAGTTTGGGTTTGTGGATGCCCAGAAGGAAGACATGC
CCCCAGAACATGTCAGGAAGATCATTCGAGACCATGGAGACATGACCAACAGGAAGTTCCGCCATGACAAAAGGGTTTACTTGGGTGCCC
TAAAGTACATGCCCCACGCAGTCCTCAAACTCCTGGAGAACATGCCTATGCCTTGGGAGCAGATTCGGGATGTGCCTGTGCTGTACCACA
TCACTGGAGCCATTTCCTTCGTCAATGAGATTCCCTGGGTCATTGAACCTGTCTACATCTCCCAGTGGGGGTCAATGTGGATTATGATGC
GCCGAGAAAAAAGAGATAGGAGGCATTTCAAGAGGATGCGTTTTCCCCCTTTTGATGATGAGGAGCCGCCCTTGGACTATGCTGACAACA
TCCTAGATGTTGAGCCACTGGAGGCCATTCAGCTAGAGCTGGACCCTGAGGAGGACGCCCCTGTGTTGGACTGGTTCTATGACCACCAGC
CGTTGAGGGACAGCAGGAAGTATGTAAATGGCTCCACTTACCAGCGCTGGCAGTTCACACTACCTATGATGTCGACTCTCTACCGCCTGG
CTAATCAGCTCCTGACAGACTTGGTGGATGACAACTACTTCTACCTGTTTGATTTGAAGGCCTTCTTTACGTCCAAGGCACTCAATATGG
CCATTCCTGGAGGCCCCAAATTTGAACCTCTTGTTCGAGACATCAACCTACAGGATGAAGACTGGAATGAATTCAATGATATTAACAAGA
TTATCATCCGGCAGCCTATCCGCACTGAGTACAAGATTGCTTTTCCTTACTTGTACAACAATCTTCCACACCATGTCCACCTCACCTGGT
ACCATACTCCCAATGTTGTATTCATCAAAACTGAGGATCCTGACTTGCCAGCTTTCTACTTTGACCCTTTGATCAACCCAATCTCCCATA
GGCACTCAGTCAAGAGCCAGGAACCATTGCCGGATGATGATGAGGAATTTGAGCTCCCGGAGTTTGTGGAGCCCTTCCTGAAGGACACAC
CCCTCTATACAGACAATACAGCCAATGGCATTGCCCTGCTCTGGGCCCCGCGGCCCTTCAACCTACGCTCTGGTCGCACCCGTCGGGCCC
TGGACATACCCCTTGTCAAGAACTGGTATCGGGAGCATTGTCCTGCCGGGCAGCCTGTGAAAGTGAGGGTCTCCTACCAGAAGCTGCTTA
AGTACTATGTGCTGAATGCCCTGAAGCATCGGCCCCCTAAGGCTCAAAAGAAGAGGTATTTGTTCCGCTCCTTCAAAGCCACCAAATTCT
TTCAGTCCACAAAGCTGGACTGGGTGGAGGTTGGGCTCCAGGTTTGCCGCCAGGGCTACAACATGCTCAACCTTCTCATTCACCGCAAAA
ACCTCAACTACCTGCACCTGGACTACAACTTCAACCTCAAGCCTGTGAAAACGCTCACCACCAAGGAAAGAAAGAAATCTCGTTTTGGGA
ATGCTTTCCACCTGTGTCGGGAAGTTCTGCGTTTGACTAAGCTGGTGGTGGATAGTCACGTGCAGTATCGGCTGGGCAATGTGGATGCCT
TCCAGCTGGCAGATGGATTGCAGTATATATTTGCCCATGTTGGGCAGTTGACGGGCATGTATCGATACAAATACAAGCTGATGCGACAGA
TTCGCATGTGCAAGGACCTGAAGCATCTCATCTATTATCGTTTCAACACGGCCAAACGTACCAAGAAAGTCGGGATCGTCGGTAAATACG
GGACCCGCTATGGGGCCTCCCTCCGGAAAATGGTGAAGAAAATTGAAATCAGCCAGCACGCCAAGTACACTTGCTCTTTCTGTGGCAAAA
CCAAGATGAAGAGACGAGCTGTGGGGATCTGGCACTGTGGTTCCTGCATGAAGACAGTGGCTGGCGGTGCCTGGACGTACAAGTAACCTA
AGCAAACCCAAATGGACCAAATGCAACGCTGATGGAATCTAAGTGCTCAGACCAAGGAACGGGGACTGAAATAACAGTGGACACCACATG

>In-frame_ENST00000572621_ENST00000600880_BG478185_PRPF8_chr17_1581811_-_RPL37A_chr2_217363988_length(amino acids)=689AA_start in transcript=266_stop in transcript=2335
MAGVFPYRGPGNPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKRYAEKRKFGFVDAQKEDMPPEHVRKIIRDHGDMTNRKFRHDKRVYLG
ALKYMPHAVLKLLENMPMPWEQIRDVPVLYHITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYAD
NILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYRLANQLLTDLVDDNYFYLFDLKAFFTSKALN
MAIPGGPKFEPLVRDINLQDEDWNEFNDINKIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKTEDPDLPAFYFDPLINPIS
HRHSVKSQEPLPDDDEEFELPEFVEPFLKDTPLYTDNTANGIALLWAPRPFNLRSGRTRRALDIPLVKNWYREHCPAGQPVKVRVSYQKL
LKYYVLNALKHRPPKAQKKRYLFRSFKATKFFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRF
GNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMRQIRMCKDLKHLIYYRFNTAKRTKKVGIVGK

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>In-frame_ENST00000572621_ENST00000446558_BG478185_PRPF8_chr17_1581811_-_RPL37A_chr2_217363988_length(transcript)=2592nt_BP=2120nt
GCAGTCTGGCCGCCATTGCGCTGCGGGGAAAGCGGCCTCTTGTGTGAGGGCCTGTGGGGTGCGTGGCAGGCGTTTAAGGCCGGGCTGCGG
GAGGCGTGGTCGGGTCGGGCCGAGTGACCGAAGGGGTTAGGCCGGGCGGGGCTGGATGCACTGTGTGGCGGGACTGCAGGCCGGGGTCCC
CGGACGCCTTTCTGCTGCGCTTCTTGTGGGCCCGGGCCTGTGGTTAGTGAATTTTTCTATCCCGCCGCTCCCCAGATTCTCCGGATATGG
CCGGAGTGTTTCCTTATCGAGGGCCGGGTAACCCGGTGCCTGGCCCTCTAGCCCCGCTACCGGACTACATGTCGGAGGAGAAGCTGCAGG
AGAAAGCTCGAAAATGGCAGCAATTGCAGGCCAAGCGCTATGCAGAAAAGCGGAAGTTTGGGTTTGTGGATGCCCAGAAGGAAGACATGC
CCCCAGAACATGTCAGGAAGATCATTCGAGACCATGGAGACATGACCAACAGGAAGTTCCGCCATGACAAAAGGGTTTACTTGGGTGCCC
TAAAGTACATGCCCCACGCAGTCCTCAAACTCCTGGAGAACATGCCTATGCCTTGGGAGCAGATTCGGGATGTGCCTGTGCTGTACCACA
TCACTGGAGCCATTTCCTTCGTCAATGAGATTCCCTGGGTCATTGAACCTGTCTACATCTCCCAGTGGGGGTCAATGTGGATTATGATGC
GCCGAGAAAAAAGAGATAGGAGGCATTTCAAGAGGATGCGTTTTCCCCCTTTTGATGATGAGGAGCCGCCCTTGGACTATGCTGACAACA
TCCTAGATGTTGAGCCACTGGAGGCCATTCAGCTAGAGCTGGACCCTGAGGAGGACGCCCCTGTGTTGGACTGGTTCTATGACCACCAGC
CGTTGAGGGACAGCAGGAAGTATGTAAATGGCTCCACTTACCAGCGCTGGCAGTTCACACTACCTATGATGTCGACTCTCTACCGCCTGG
CTAATCAGCTCCTGACAGACTTGGTGGATGACAACTACTTCTACCTGTTTGATTTGAAGGCCTTCTTTACGTCCAAGGCACTCAATATGG
CCATTCCTGGAGGCCCCAAATTTGAACCTCTTGTTCGAGACATCAACCTACAGGATGAAGACTGGAATGAATTCAATGATATTAACAAGA
TTATCATCCGGCAGCCTATCCGCACTGAGTACAAGATTGCTTTTCCTTACTTGTACAACAATCTTCCACACCATGTCCACCTCACCTGGT
ACCATACTCCCAATGTTGTATTCATCAAAACTGAGGATCCTGACTTGCCAGCTTTCTACTTTGACCCTTTGATCAACCCAATCTCCCATA
GGCACTCAGTCAAGAGCCAGGAACCATTGCCGGATGATGATGAGGAATTTGAGCTCCCGGAGTTTGTGGAGCCCTTCCTGAAGGACACAC
CCCTCTATACAGACAATACAGCCAATGGCATTGCCCTGCTCTGGGCCCCGCGGCCCTTCAACCTACGCTCTGGTCGCACCCGTCGGGCCC
TGGACATACCCCTTGTCAAGAACTGGTATCGGGAGCATTGTCCTGCCGGGCAGCCTGTGAAAGTGAGGGTCTCCTACCAGAAGCTGCTTA
AGTACTATGTGCTGAATGCCCTGAAGCATCGGCCCCCTAAGGCTCAAAAGAAGAGGTATTTGTTCCGCTCCTTCAAAGCCACCAAATTCT
TTCAGTCCACAAAGCTGGACTGGGTGGAGGTTGGGCTCCAGGTTTGCCGCCAGGGCTACAACATGCTCAACCTTCTCATTCACCGCAAAA
ACCTCAACTACCTGCACCTGGACTACAACTTCAACCTCAAGCCTGTGAAAACGCTCACCACCAAGGAAAGAAAGAAATCTCGTTTTGGGA
ATGCTTTCCACCTGTGTCGGGAAGTTCTGCGTTTGACTAAGCTGGTGGTGGATAGTCACGTGCAGTATCGGCTGGGCAATGTGGATGCCT
TCCAGCTGGCAGATGGATTGCAGTATATATTTGCCCATGTTGGGCAGTTGACGGGCATGTATCGATACAAATACAAGCTGATGCGACAGA
TTCGCATGTGCAAGGACCTGAAGCATCTCATCTATTATCGTTTCAACACGGCCAAACGTACCAAGAAAGTCGGGATCGTCGGTAAATACG
GGACCCGCTATGGGGCCTCCCTCCGGAAAATGGTGAAGAAAATTGAAATCAGCCAGCACGCCAAGTACACTTGCTCTTTCTGTGGCAAAA
CCAAGATGAAGAGACGAGCTGTGGGGATCTGGCACTGTGGTTCCTGCATGAAGACAGTGGCTGGCGGTGCCTGGACGTACAACAGAATGG
AATAACAGCAAACAACATTGGAGGAGGACTTGTCTGGGAGAGCAGCCATTTTAAAGAAGAGCACATTAAGTCACAAACAGTCGCAGCTGA
TCTACTTTGCAGCATCGCCATACATGCCTAACTAAATATTGAAATCCCGGGAAAAACTCACTGTGCATCATGTTCCAGAAACTAGCTTTG

>In-frame_ENST00000572621_ENST00000446558_BG478185_PRPF8_chr17_1581811_-_RPL37A_chr2_217363988_length(amino acids)=692AA_start in transcript=266_stop in transcript=2344
MAGVFPYRGPGNPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKRYAEKRKFGFVDAQKEDMPPEHVRKIIRDHGDMTNRKFRHDKRVYLG
ALKYMPHAVLKLLENMPMPWEQIRDVPVLYHITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYAD
NILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSTLYRLANQLLTDLVDDNYFYLFDLKAFFTSKALN
MAIPGGPKFEPLVRDINLQDEDWNEFNDINKIIIRQPIRTEYKIAFPYLYNNLPHHVHLTWYHTPNVVFIKTEDPDLPAFYFDPLINPIS
HRHSVKSQEPLPDDDEEFELPEFVEPFLKDTPLYTDNTANGIALLWAPRPFNLRSGRTRRALDIPLVKNWYREHCPAGQPVKVRVSYQKL
LKYYVLNALKHRPPKAQKKRYLFRSFKATKFFQSTKLDWVEVGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRF
GNAFHLCREVLRLTKLVVDSHVQYRLGNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMRQIRMCKDLKHLIYYRFNTAKRTKKVGIVGK

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Fusion Gene PPI Analysis for PRPF8-RPL37A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PRPF8-RPL37A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PRPF8-RPL37A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePRPF8C1838702Retinitis Pigmentosa 134CTD_human;GENOMICS_ENGLAND;UNIPROT
HgenePRPF8C0019693HIV Infections1CTD_human
HgenePRPF8C0038454Cerebrovascular accident1CTD_human
HgenePRPF8C0751956Acute Cerebrovascular Accidents1CTD_human
HgenePRPF8C4505456HIV Coinfection1CTD_human
TgeneRPL37AC0032460Polycystic Ovary Syndrome1CTD_human
TgeneRPL37AC1136382Sclerocystic Ovaries1CTD_human