FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:PRSS12-GAS2L3 (FusionGDB2 ID:68866)

Fusion Gene Summary for PRSS12-GAS2L3

check button Fusion gene summary
Fusion gene informationFusion gene name: PRSS12-GAS2L3
Fusion gene ID: 68866
HgeneTgene
Gene symbol

PRSS12

GAS2L3

Gene ID

8492

283431

Gene nameserine protease 12growth arrest specific 2 like 3
SynonymsBSSP-3|BSSP3|MRT1G2L3
Cytomap

4q26

12q23.1

Type of geneprotein-codingprotein-coding
Descriptionneurotrypsinbrain-specific serine protease 3leydinprotease, serine 12protease, serine, 12 (neurotrypsin, motopsin)GAS2-like protein 3growth arrest-specific protein 2-like 3
Modification date2020031320200313
UniProtAcc.

Q86XJ1

Ensembl transtripts involved in fusion geneENST00000296498, ENST00000510903, 
ENST00000266754, ENST00000547754, 
ENST00000547739, ENST00000539410, 
ENST00000537247, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 3 X 2=18
# samples 33
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PRSS12 [Title/Abstract] AND GAS2L3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPRSS12(119203986)-GAS2L3(101011522), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGAS2L3

GO:0000226

microtubule cytoskeleton organization

21561867

TgeneGAS2L3

GO:0030036

actin cytoskeleton organization

21561867


check buttonFusion gene breakpoints across PRSS12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GAS2L3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-A48C-01APRSS12chr4

119203986

-GAS2L3chr12

101011522

+


Top

Fusion Gene ORF analysis for PRSS12-GAS2L3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000296498ENST00000266754PRSS12chr4

119203986

-GAS2L3chr12

101011522

+
In-frameENST00000296498ENST00000547754PRSS12chr4

119203986

-GAS2L3chr12

101011522

+
5CDS-intronENST00000296498ENST00000547739PRSS12chr4

119203986

-GAS2L3chr12

101011522

+
5CDS-intronENST00000296498ENST00000539410PRSS12chr4

119203986

-GAS2L3chr12

101011522

+
5CDS-intronENST00000296498ENST00000537247PRSS12chr4

119203986

-GAS2L3chr12

101011522

+
intron-3CDSENST00000510903ENST00000266754PRSS12chr4

119203986

-GAS2L3chr12

101011522

+
intron-3CDSENST00000510903ENST00000547754PRSS12chr4

119203986

-GAS2L3chr12

101011522

+
intron-intronENST00000510903ENST00000547739PRSS12chr4

119203986

-GAS2L3chr12

101011522

+
intron-intronENST00000510903ENST00000539410PRSS12chr4

119203986

-GAS2L3chr12

101011522

+
intron-intronENST00000510903ENST00000537247PRSS12chr4

119203986

-GAS2L3chr12

101011522

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000296498PRSS12chr4119203986-ENST00000266754GAS2L3chr12101011522+4243260328342421320
ENST00000296498PRSS12chr4119203986-ENST00000547754GAS2L3chr12101011522+4272260328342421319

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296498ENST00000266754PRSS12chr4119203986-GAS2L3chr12101011522+0.0012941810.99870586
ENST00000296498ENST00000547754PRSS12chr4119203986-GAS2L3chr12101011522+0.0011867410.9988133

Top

Fusion Genomic Features for PRSS12-GAS2L3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PRSS12chr4119203985-GAS2L3chr12101011521+0.079890940.9201091
PRSS12chr4119203985-GAS2L3chr12101011521+0.079890940.9201091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for PRSS12-GAS2L3


check button Go to

FGviewer for the breakpoints of chr4:119203986-chr12:101011522

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GAS2L3

Q86XJ1

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network. {ECO:0000269|PubMed:21561867}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRSS12chr4:119203986chr12:101011522ENST00000296498-121323_92773.3333333333334876.0Compositional biasNote=Pro-rich
HgenePRSS12chr4:119203986chr12:101011522ENST00000296498-1213170_271773.3333333333334876.0DomainSRCR 1
HgenePRSS12chr4:119203986chr12:101011522ENST00000296498-1213280_381773.3333333333334876.0DomainSRCR 2
HgenePRSS12chr4:119203986chr12:101011522ENST00000296498-1213387_487773.3333333333334876.0DomainSRCR 3
HgenePRSS12chr4:119203986chr12:101011522ENST00000296498-1213500_601773.3333333333334876.0DomainSRCR 4
HgenePRSS12chr4:119203986chr12:101011522ENST00000296498-1213619_630773.3333333333334876.0RegionNote=Zymogen activation region
TgeneGAS2L3chr4:119203986chr12:101011522ENST0000026675449208_281148.33333333333334695.0DomainGAR
TgeneGAS2L3chr4:119203986chr12:101011522ENST0000053941049208_281148.33333333333334695.0DomainGAR
TgeneGAS2L3chr4:119203986chr12:101011522ENST00000547754510208_281148.33333333333334695.0DomainGAR

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRSS12chr4:119203986chr12:101011522ENST00000296498-1213631_874773.3333333333334876.0DomainPeptidase S1
TgeneGAS2L3chr4:119203986chr12:101011522ENST000002667544948_168148.33333333333334695.0DomainCalponin-homology (CH)
TgeneGAS2L3chr4:119203986chr12:101011522ENST000005394104948_168148.33333333333334695.0DomainCalponin-homology (CH)
TgeneGAS2L3chr4:119203986chr12:101011522ENST0000054775451048_168148.33333333333334695.0DomainCalponin-homology (CH)


Top

Fusion Gene Sequence for PRSS12-GAS2L3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000296498_ENST00000266754_TCGA-CD-A48C-01A_PRSS12_chr4_119203986_-_GAS2L3_chr12_101011522_length(transcript)=4243nt_BP=2603nt
GCTGCGTCCGCGCCTTCTCTTTTCCGGTCCTCTCCGCCGGCCGGGGCTCGGCTGAGCTCCAGATTTCCCCACCCGCGGCCGCCGCCAGGG
GACAGGAGCCGAGGCGCGGCAGGGCACCAGCGGCGGGAGGCAAGGTTGGGGAGGCGAGGGCGGTCCGCGTGCGGGGGCGGGAGGGGGCTG
GGGGATTCGAGGGACGCGGCAGCCCCGCCCCCGCCCCCTCCTCTTCTCCGCTCCAAGCCCGAGAAGCTGGGGAGCATGGACCAGACCCCG
CAGCGCTGGCACCATGACGCTCGCCCGCTTCGTGCTAGCCCTGATGTTAGGGGCGCTCCCCGAAGTGGTCGGCTTTGATTCTGTCCTCAA
TGATTCCCTCCACCACAGCCACCGCCATTCGCCCCCTGCGGGTCCGCACTACCCCTATTACCTTCCCACCCAGCAGCGGCCCCCGAGGAC
GCGTCCGCCGCCGCCTCTCCCGCGCTTCCCGCGCCCCCCGCGGGCGCTCCCTGCCCAGCGCCCGCACGCCCTCCAGGCCGGGCACACGCC
CCGGCCGCACCCCTGGGGCTGCCCCGCCGGCGAGCCATGGGTCAGCGTGACGGACTTCGGCGCCCCGTGTCTGCGGTGGGCGGAGGTGCC
ACCCTTCCTGGAGCGGTCGCCCCCAGCGAGCTGGGCTCAGCTGCGAGGACAGCGCCACAACTTTTGTCGGAGCCCCGACGGCGCGGGCAG
ACCCTGGTGTTTCTACGGAGACGCCCGTGGCAAGGTGGACTGGGGCTACTGCGACTGCAGACACGGATCAGTACGACTTCGTGGCGGCAA
AAATGAGTTTGAAGGCACAGTGGAAGTATATGCAAGTGGAGTTTGGGGCACTGTCTGTAGCAGCCACTGGGATGATTCTGATGCATCAGT
CATTTGTCACCAGCTGCAGCTGGGAGGAAAAGGAATAGCAAAACAAACCCCGTTTTCTGGACTGGGCCTTATTCCCATTTATTGGAGCAA
TGTCCGTTGCCGAGGAGATGAAGAAAATATACTGCTTTGTGAAAAAGACATCTGGCAGGGTGGGGTGTGTCCTCAGAAGATGGCAGCTGC
TGTCACGTGTAGCTTTTCCCATGGCCCAACGTTCCCCATCATTCGCCTTGCTGGAGGCAGCAGTGTGCATGAAGGCCGGGTGGAGCTCTA
CCATGCTGGCCAGTGGGGAACCGTTTGTGATGACCAATGGGATGATGCCGATGCAGAAGTGATCTGCAGGCAGCTGGGCCTCAGTGGCAT
TGCCAAAGCATGGCATCAGGCATATTTTGGGGAAGGGTCTGGCCCAGTTATGTTGGATGAAGTACGCTGCACTGGGAATGAGCTTTCAAT
TGAGCAGTGTCCAAAGAGCTCCTGGGGAGAGCATAACTGTGGCCATAAAGAAGATGCTGGAGTGTCCTGTACCCCTCTAACAGATGGGGT
CATCAGACTTGCAGGTGGGAAAGGCAGCCATGAGGGTCGCTTGGAGGTATATTACAGAGGCCAGTGGGGAACTGTCTGTGATGATGGCTG
GACTGAGCTGAATACATACGTGGTTTGTCGACAATTGGGATTTAAATATGGTAAACAAGCATCTGCCAACCATTTTGAAGAAAGCACAGG
GCCCATATGGTTGGATGACGTCAGCTGCTCAGGAAAGGAAACCAGATTTCTTCAGTGTTCCAGGCGACAGTGGGGAAGGCATGACTGCAG
CCACCGCGAAGATGTTAGCATTGCCTGCTACCCTGGCGGCGAGGGACACAGGCTCTCTCTGGGTTTTCCTGTCAGACTGATGGATGGAGA
AAATAAGAAAGAAGGACGAGTGGAGGTTTTTATCAATGGCCAGTGGGGAACAATCTGTGATGATGGATGGACTGATAAGGATGCAGCTGT
GATCTGTCGTCAGCTTGGCTACAAGGGTCCTGCCAGAGCAAGAACCATGGCTTACTTTGGAGAAGGAAAAGGACCCATCCATGTGGATAA
TGTGAAGTGCACAGGAAATGAGAGGTCCTTGGCTGACTGTATCAAGCAAGATATTGGAAGACACAACTGCCGCCACAGTGAAGATGCAGG
AGTTATTTGTGATTATTTTGGCAAGAAGGCCTCAGGTAACAGTAATAAAGAGTCCCTCTCATCTGTTTGTGGCTTGAGATTACTGCACCG
TCGGCAGAAGCGGATCATTGGTGGGAAAAATTCTTTAAGGGGTGGTTGGCCTTGGCAGGTTTCCCTCCGGCTGAAGTCATCCCATGGAGA
TGGCAGGCTCCTCTGCGGGGCTACGCTCCTGAGTAGCTGCTGGGTCCTCACAGCAGCACACTGTTTCAAGAGGTATGGCAACAGCACTAG
GAGCTATGCTGTTAGGGTTGGAGATTATCATACTCTGGTACCAGAGGAGTTTGAGGAAGAAATTGGAGTTCAACAGATTGTGATTCATCG
GGAGTATCGACCCGACCGCAGTGATTATGACATAGCCCTGGTTAGATTACAAGGACCAGAAGAGCAATGTGCCAGATTCAGCAGCCATGT
TTTGCCAGCCTGTTTACCACTCTGGAGAGAGAGGCCACAGAAAACAGCATCCAACTGTTACATAACAGGATGGGGTGACACAGTTTTGCA
CAAAGATCCAAGACAGGTGTATCTTTGTCTTCTTGAAATTGGTCGAATTGTGTCAAGATACGGGGTTGAGCCACCAGTGTTAGTAAAACT
TGAGAAAGAAATTGAGTTAGAAGAGACTTTGCTTAATACTTCTGGGCCTGAAGATTCCATCAGCATTCCAAAATCATGCTGTCGGCATGA
AGAGCTACATGAAGCTGTTAAACATATTGCTGAGGACCCTCCTTGTAGTTGTTCTCATCGATTTTCTATTGAGTATTTATCTGAAGGACG
GTACCGACTAGGGGATAAAATACTCTTTATAAGAATGCTTCATGGAAAACATGTCATGGTTCGCGTTGGTGGAGGCTGGGATACTCTTCA
AGGATTTTTGCTTAAATATGACCCCTGTCGAATATTACAGTTTGCCACATTAGAACAAAAAATTTTAGCATTTCAAAAAGGAGTTTCTAA
TGAAAGTGTACCTGATTCGCCTGCCAGAACACCTCAGCCTCCTGAAATGAATCCTTTGTCAGCAGTTAACATGTTTCAGAAACAAAATTC
AAAACCCAGCGTGCCAGTTAGTATTCCAAAAAGCAAAGAAAAACAGGGACGTCCACCAGGTGCATTGGTGCCAGCATCTTCACTGAAAGG
AGGTAATCTGGGCTCTATGTCAGTCCGTTCTAAATTGCCAAATTCTCCAGCAGCATCTTCTCATCCCAAGCTCAAGTCTTCAAAAGGCAT
AACGAAGAAACCGCAGGCTCCTTCAAACAATGCATCATCTTCACTTGCTTCATTAAATCCAGTAGGTAAAAACACTTCTTCACCAGCTTT
ACCAAGAACTGCACCTTGTATATCTGAGTCACCGAGAAAATGTATTTCATCCCCCAATACCCCCAAGGCCAAGGTTATTCCAGCCCAGAA
TTCAGCAGATCTGCCCGAGTCCACACTTTTGCCAAATAAGTGTTCAGGAAAAACTCAACCTAAGTATTTGAAACATAATCATATTTCTTC
CAGAGATAATGCAGTATCTCACTTAGCTGCACATTCAAATTCATCCTCAAAATGTCCCAAGCTGCCTAAAGCAAATATACCTGTAAGACC
TAAACCTTCTTTCCAGTCCTCTGCAAAAATGACAAAAACCAGTTCCAAAACCATAGCCACGGGTCTAGGAACACAGTCTCAACCATCCGA
TGGAGCCCCACAAGCAAAGCCAGTCCCAGCACAGAAACTTAAATCGGCCTTGAATTTAAATCAGCCAGTTTCTGTGTCCTCAGTTTCTCC
TGTAAAAGCCACACAGAAATCAAAAGATAAGAATATAGTTTCAGCTACCAAAAAGCAGCCTCAGAATAAAAGTGCATTTCAGAAGACAGG
ACCCAGCTCCTTGAAGTCTCCTGGCCGTACCCCACTGTCCATCGTGAGCCTACCCCAGTCTTCTACCAAAACACAAACTGCACCGAAGTC
AGCACAGACTGTCGCTAAGAGCCAGCATTCAACTAAAGGGCCTCCCAGAAGTGGCAAAACCCCAGCTTCAATCAGGAAACCACCCTCATC
TGTTAAGGATGCAGATAGTGGAGATAAAAAACCTACTGCAAAGAAAAAGGAAGATGATGACCATTATTTTGTCATGACTGGAAGTAAGAA

>In-frame_ENST00000296498_ENST00000266754_TCGA-CD-A48C-01A_PRSS12_chr4_119203986_-_GAS2L3_chr12_101011522_length(amino acids)=1320AA_start in transcript=283_stop in transcript=4242
MTLARFVLALMLGALPEVVGFDSVLNDSLHHSHRHSPPAGPHYPYYLPTQQRPPRTRPPPPLPRFPRPPRALPAQRPHALQAGHTPRPHP
WGCPAGEPWVSVTDFGAPCLRWAEVPPFLERSPPASWAQLRGQRHNFCRSPDGAGRPWCFYGDARGKVDWGYCDCRHGSVRLRGGKNEFE
GTVEVYASGVWGTVCSSHWDDSDASVICHQLQLGGKGIAKQTPFSGLGLIPIYWSNVRCRGDEENILLCEKDIWQGGVCPQKMAAAVTCS
FSHGPTFPIIRLAGGSSVHEGRVELYHAGQWGTVCDDQWDDADAEVICRQLGLSGIAKAWHQAYFGEGSGPVMLDEVRCTGNELSIEQCP
KSSWGEHNCGHKEDAGVSCTPLTDGVIRLAGGKGSHEGRLEVYYRGQWGTVCDDGWTELNTYVVCRQLGFKYGKQASANHFEESTGPIWL
DDVSCSGKETRFLQCSRRQWGRHDCSHREDVSIACYPGGEGHRLSLGFPVRLMDGENKKEGRVEVFINGQWGTICDDGWTDKDAAVICRQ
LGYKGPARARTMAYFGEGKGPIHVDNVKCTGNERSLADCIKQDIGRHNCRHSEDAGVICDYFGKKASGNSNKESLSSVCGLRLLHRRQKR
IIGGKNSLRGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCFKRYGNSTRSYAVRVGDYHTLVPEEFEEEIGVQQIVIHREYRP
DRSDYDIALVRLQGPEEQCARFSSHVLPACLPLWRERPQKTASNCYITGWGDTVLHKDPRQVYLCLLEIGRIVSRYGVEPPVLVKLEKEI
ELEETLLNTSGPEDSISIPKSCCRHEELHEAVKHIAEDPPCSCSHRFSIEYLSEGRYRLGDKILFIRMLHGKHVMVRVGGGWDTLQGFLL
KYDPCRILQFATLEQKILAFQKGVSNESVPDSPARTPQPPEMNPLSAVNMFQKQNSKPSVPVSIPKSKEKQGRPPGALVPASSLKGGNLG
SMSVRSKLPNSPAASSHPKLKSSKGITKKPQAPSNNASSSLASLNPVGKNTSSPALPRTAPCISESPRKCISSPNTPKAKVIPAQNSADL
PESTLLPNKCSGKTQPKYLKHNHISSRDNAVSHLAAHSNSSSKCPKLPKANIPVRPKPSFQSSAKMTKTSSKTIATGLGTQSQPSDGAPQ
AKPVPAQKLKSALNLNQPVSVSSVSPVKATQKSKDKNIVSATKKQPQNKSAFQKTGPSSLKSPGRTPLSIVSLPQSSTKTQTAPKSAQTV

--------------------------------------------------------------
>In-frame_ENST00000296498_ENST00000547754_TCGA-CD-A48C-01A_PRSS12_chr4_119203986_-_GAS2L3_chr12_101011522_length(transcript)=4272nt_BP=2603nt
GCTGCGTCCGCGCCTTCTCTTTTCCGGTCCTCTCCGCCGGCCGGGGCTCGGCTGAGCTCCAGATTTCCCCACCCGCGGCCGCCGCCAGGG
GACAGGAGCCGAGGCGCGGCAGGGCACCAGCGGCGGGAGGCAAGGTTGGGGAGGCGAGGGCGGTCCGCGTGCGGGGGCGGGAGGGGGCTG
GGGGATTCGAGGGACGCGGCAGCCCCGCCCCCGCCCCCTCCTCTTCTCCGCTCCAAGCCCGAGAAGCTGGGGAGCATGGACCAGACCCCG
CAGCGCTGGCACCATGACGCTCGCCCGCTTCGTGCTAGCCCTGATGTTAGGGGCGCTCCCCGAAGTGGTCGGCTTTGATTCTGTCCTCAA
TGATTCCCTCCACCACAGCCACCGCCATTCGCCCCCTGCGGGTCCGCACTACCCCTATTACCTTCCCACCCAGCAGCGGCCCCCGAGGAC
GCGTCCGCCGCCGCCTCTCCCGCGCTTCCCGCGCCCCCCGCGGGCGCTCCCTGCCCAGCGCCCGCACGCCCTCCAGGCCGGGCACACGCC
CCGGCCGCACCCCTGGGGCTGCCCCGCCGGCGAGCCATGGGTCAGCGTGACGGACTTCGGCGCCCCGTGTCTGCGGTGGGCGGAGGTGCC
ACCCTTCCTGGAGCGGTCGCCCCCAGCGAGCTGGGCTCAGCTGCGAGGACAGCGCCACAACTTTTGTCGGAGCCCCGACGGCGCGGGCAG
ACCCTGGTGTTTCTACGGAGACGCCCGTGGCAAGGTGGACTGGGGCTACTGCGACTGCAGACACGGATCAGTACGACTTCGTGGCGGCAA
AAATGAGTTTGAAGGCACAGTGGAAGTATATGCAAGTGGAGTTTGGGGCACTGTCTGTAGCAGCCACTGGGATGATTCTGATGCATCAGT
CATTTGTCACCAGCTGCAGCTGGGAGGAAAAGGAATAGCAAAACAAACCCCGTTTTCTGGACTGGGCCTTATTCCCATTTATTGGAGCAA
TGTCCGTTGCCGAGGAGATGAAGAAAATATACTGCTTTGTGAAAAAGACATCTGGCAGGGTGGGGTGTGTCCTCAGAAGATGGCAGCTGC
TGTCACGTGTAGCTTTTCCCATGGCCCAACGTTCCCCATCATTCGCCTTGCTGGAGGCAGCAGTGTGCATGAAGGCCGGGTGGAGCTCTA
CCATGCTGGCCAGTGGGGAACCGTTTGTGATGACCAATGGGATGATGCCGATGCAGAAGTGATCTGCAGGCAGCTGGGCCTCAGTGGCAT
TGCCAAAGCATGGCATCAGGCATATTTTGGGGAAGGGTCTGGCCCAGTTATGTTGGATGAAGTACGCTGCACTGGGAATGAGCTTTCAAT
TGAGCAGTGTCCAAAGAGCTCCTGGGGAGAGCATAACTGTGGCCATAAAGAAGATGCTGGAGTGTCCTGTACCCCTCTAACAGATGGGGT
CATCAGACTTGCAGGTGGGAAAGGCAGCCATGAGGGTCGCTTGGAGGTATATTACAGAGGCCAGTGGGGAACTGTCTGTGATGATGGCTG
GACTGAGCTGAATACATACGTGGTTTGTCGACAATTGGGATTTAAATATGGTAAACAAGCATCTGCCAACCATTTTGAAGAAAGCACAGG
GCCCATATGGTTGGATGACGTCAGCTGCTCAGGAAAGGAAACCAGATTTCTTCAGTGTTCCAGGCGACAGTGGGGAAGGCATGACTGCAG
CCACCGCGAAGATGTTAGCATTGCCTGCTACCCTGGCGGCGAGGGACACAGGCTCTCTCTGGGTTTTCCTGTCAGACTGATGGATGGAGA
AAATAAGAAAGAAGGACGAGTGGAGGTTTTTATCAATGGCCAGTGGGGAACAATCTGTGATGATGGATGGACTGATAAGGATGCAGCTGT
GATCTGTCGTCAGCTTGGCTACAAGGGTCCTGCCAGAGCAAGAACCATGGCTTACTTTGGAGAAGGAAAAGGACCCATCCATGTGGATAA
TGTGAAGTGCACAGGAAATGAGAGGTCCTTGGCTGACTGTATCAAGCAAGATATTGGAAGACACAACTGCCGCCACAGTGAAGATGCAGG
AGTTATTTGTGATTATTTTGGCAAGAAGGCCTCAGGTAACAGTAATAAAGAGTCCCTCTCATCTGTTTGTGGCTTGAGATTACTGCACCG
TCGGCAGAAGCGGATCATTGGTGGGAAAAATTCTTTAAGGGGTGGTTGGCCTTGGCAGGTTTCCCTCCGGCTGAAGTCATCCCATGGAGA
TGGCAGGCTCCTCTGCGGGGCTACGCTCCTGAGTAGCTGCTGGGTCCTCACAGCAGCACACTGTTTCAAGAGGTATGGCAACAGCACTAG
GAGCTATGCTGTTAGGGTTGGAGATTATCATACTCTGGTACCAGAGGAGTTTGAGGAAGAAATTGGAGTTCAACAGATTGTGATTCATCG
GGAGTATCGACCCGACCGCAGTGATTATGACATAGCCCTGGTTAGATTACAAGGACCAGAAGAGCAATGTGCCAGATTCAGCAGCCATGT
TTTGCCAGCCTGTTTACCACTCTGGAGAGAGAGGCCACAGAAAACAGCATCCAACTGTTACATAACAGGATGGGGTGACACAGTTTTGCA
CAAAGATCCAAGACAGGTGTATCTTTGTCTTCTTGAAATTGGTCGAATTGTGTCAAGATACGGGGTTGAGCCACCAGTGTTAGTAAAACT
TGAGAAAGAAATTGAGTTAGAAGAGACTTTGCTTAATACTTCTGGGCCTGAAGATTCCATCAGCATTCCAAAATCATGCTGTCGGCATGA
AGAGCTACATGAAGCTGTTAAACATATTGCTGAGGACCCTCCTTGTAGTTGTTCTCATCGATTTTCTATTGAGTATTTATCTGAAGGACG
GTACCGACTAGGGGATAAAATACTCTTTATAAGAATGCTTCATGGAAAACATGTCATGGTTCGCGTTGGTGGAGGCTGGGATACTCTTCA
AGGATTTTTGCTTAAATATGACCCCTGTCGAATATTACAGTTTGCCACATTAGAACAAAAAATTTTAGCATTTCAAAAAGGAGTTTCTAA
TGAAAGTGTACCTGATTCGCCTGCCAGAACACCTCAGCCTCCTGAAATGAATCCTTTGTCAGCAGTTAACATGTTTCAGAAACAAAATTC
AAAACCCAGCGTGCCAGTTAGTATTCCAAAAAGCAAAGAAAAACAGGGACGTCCACCAGGTGCATTGGTGCCAGCATCTTCACTGAAAGG
AGGTAATCTGGGCTCTATGTCAGTCCGTTCTAAATTGCCAAATTCTCCAGCAGCATCTTCTCATCCCAAGCTCAAGTCTTCAAAAGGCAT
AACGAAGAAACCGCAGGCTCCTTCAAACAATGCATCATCTTCACTTGCTTCATTAAATCCAGTAGGTAAAAACACTTCTTCACCAGCTTT
ACCAAGAACTGCACCTTGTATATCTGAGTCACCGAGAAAATGTATTTCATCCCCCAATACCCCCAAGGCCAAGGTTATTCCAGCCCAGAA
TTCAGCAGATCTGCCCGAGTCCACACTTTTGCCAAATAAGTGTTCAGGAAAAACTCAACCTAAGTATTTGAAACATAATCATATTTCTTC
CAGAGATAATGCAGTATCTCACTTAGCTGCACATTCAAATTCATCCTCAAAATGTCCCAAGCTGCCTAAAGCAAATATACCTGTAAGACC
TAAACCTTCTTTCCAGTCCTCTGCAAAAATGACAAAAACCAGTTCCAAAACCATAGCCACGGGTCTAGGAACACAGTCTCAACCATCCGA
TGGAGCCCCACAAGCAAAGCCAGTCCCAGCACAGAAACTTAAATCGGCCTTGAATTTAAATCAGCCAGTTTCTGTGTCCTCAGTTTCTCC
TGTAAAAGCCACACAGAAATCAAAAGATAAGAATATAGTTTCAGCTACCAAAAAGCAGCCTCAGAATAAAAGTGCATTTCAGAAGACAGG
ACCCAGCTCCTTGAAGTCTCCTGGCCGTACCCCACTGTCCATCGTGAGCCTACCCCAGTCTTCTACCAAAACACAAACTGCACCGAAGTC
AGCACAGACTGTCGCTAAGAGCCAGCATTCAACTAAAGGGCCTCCCAGAAGTGGCAAAACCCCAGCTTCAATCAGGAAACCACCCTCATC
TGTTAAGGATGCAGATAGTGGAGATAAAAAACCTACTGCAAAGAAAAAGGAAGATGATGACCATTATTTTGTCATGACTGGAAGTAAGAA

>In-frame_ENST00000296498_ENST00000547754_TCGA-CD-A48C-01A_PRSS12_chr4_119203986_-_GAS2L3_chr12_101011522_length(amino acids)=1319AA_start in transcript=283_stop in transcript=4242
MTLARFVLALMLGALPEVVGFDSVLNDSLHHSHRHSPPAGPHYPYYLPTQQRPPRTRPPPPLPRFPRPPRALPAQRPHALQAGHTPRPHP
WGCPAGEPWVSVTDFGAPCLRWAEVPPFLERSPPASWAQLRGQRHNFCRSPDGAGRPWCFYGDARGKVDWGYCDCRHGSVRLRGGKNEFE
GTVEVYASGVWGTVCSSHWDDSDASVICHQLQLGGKGIAKQTPFSGLGLIPIYWSNVRCRGDEENILLCEKDIWQGGVCPQKMAAAVTCS
FSHGPTFPIIRLAGGSSVHEGRVELYHAGQWGTVCDDQWDDADAEVICRQLGLSGIAKAWHQAYFGEGSGPVMLDEVRCTGNELSIEQCP
KSSWGEHNCGHKEDAGVSCTPLTDGVIRLAGGKGSHEGRLEVYYRGQWGTVCDDGWTELNTYVVCRQLGFKYGKQASANHFEESTGPIWL
DDVSCSGKETRFLQCSRRQWGRHDCSHREDVSIACYPGGEGHRLSLGFPVRLMDGENKKEGRVEVFINGQWGTICDDGWTDKDAAVICRQ
LGYKGPARARTMAYFGEGKGPIHVDNVKCTGNERSLADCIKQDIGRHNCRHSEDAGVICDYFGKKASGNSNKESLSSVCGLRLLHRRQKR
IIGGKNSLRGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCFKRYGNSTRSYAVRVGDYHTLVPEEFEEEIGVQQIVIHREYRP
DRSDYDIALVRLQGPEEQCARFSSHVLPACLPLWRERPQKTASNCYITGWGDTVLHKDPRQVYLCLLEIGRIVSRYGVEPPVLVKLEKEI
ELEETLLNTSGPEDSISIPKSCCRHEELHEAVKHIAEDPPCSCSHRFSIEYLSEGRYRLGDKILFIRMLHGKHVMVRVGGGWDTLQGFLL
KYDPCRILQFATLEQKILAFQKGVSNESVPDSPARTPQPPEMNPLSAVNMFQKQNSKPSVPVSIPKSKEKQGRPPGALVPASSLKGGNLG
SMSVRSKLPNSPAASSHPKLKSSKGITKKPQAPSNNASSSLASLNPVGKNTSSPALPRTAPCISESPRKCISSPNTPKAKVIPAQNSADL
PESTLLPNKCSGKTQPKYLKHNHISSRDNAVSHLAAHSNSSSKCPKLPKANIPVRPKPSFQSSAKMTKTSSKTIATGLGTQSQPSDGAPQ
AKPVPAQKLKSALNLNQPVSVSSVSPVKATQKSKDKNIVSATKKQPQNKSAFQKTGPSSLKSPGRTPLSIVSLPQSSTKTQTAPKSAQTV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PRSS12-GAS2L3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for PRSS12-GAS2L3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for PRSS12-GAS2L3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePRSS12C1855304MENTAL RETARDATION, AUTOSOMAL RECESSIVE 11CTD_human;GENOMICS_ENGLAND