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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:PRSS3-PRSS1 (FusionGDB2 ID:68891) |
Fusion Gene Summary for PRSS3-PRSS1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PRSS3-PRSS1 | Fusion gene ID: 68891 | Hgene | Tgene | Gene symbol | PRSS3 | PRSS1 | Gene ID | 5646 | 136541 |
| Gene name | serine protease 3 | serine protease 58 | |
| Synonyms | MTG|PRSS4|T9|TRY3|TRY4 | PRSS1|TRY1|TRYX3|UNQ2540 | |
| Cytomap | 9p13.3 | 7q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | trypsin-3brain trypsinogenmesotrypsinmesotrypsinogenpancreatic trypsinogen IIIprotease, serine 3protease, serine, 4 (trypsin 4, brain)trypsin IIItrypsin IVtrypsinogen 4trypsinogen 5trypsinogen IV | serine protease 58protease, serine 58trypsin-X3 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000361005, ENST00000342836, ENST00000429677, ENST00000379405, ENST00000495682, | ENST00000486171, ENST00000311737, | |
| Fusion gene scores | * DoF score | 7 X 4 X 4=112 | 12 X 17 X 5=1020 |
| # samples | 8 | 15 | |
| ** MAII score | log2(8/112*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/1020*10)=-2.76553474636298 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PRSS3 [Title/Abstract] AND PRSS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | PRSS3(33798080)-PRSS1(142460281), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PRSS3 | GO:0006508 | proteolysis | 6698368|11827488 |
| Hgene | PRSS3 | GO:0031638 | zymogen activation | 6698368 |
| Fusion gene breakpoints across PRSS3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across PRSS1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | Non-Cancer | 203N | PRSS3 | chr9 | 33798080 | + | PRSS1 | chr7 | 142460281 | + |
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Fusion Gene ORF analysis for PRSS3-PRSS1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000361005 | ENST00000486171 | PRSS3 | chr9 | 33798080 | + | PRSS1 | chr7 | 142460281 | + |
| In-frame | ENST00000361005 | ENST00000311737 | PRSS3 | chr9 | 33798080 | + | PRSS1 | chr7 | 142460281 | + |
| In-frame | ENST00000342836 | ENST00000486171 | PRSS3 | chr9 | 33798080 | + | PRSS1 | chr7 | 142460281 | + |
| In-frame | ENST00000342836 | ENST00000311737 | PRSS3 | chr9 | 33798080 | + | PRSS1 | chr7 | 142460281 | + |
| In-frame | ENST00000429677 | ENST00000486171 | PRSS3 | chr9 | 33798080 | + | PRSS1 | chr7 | 142460281 | + |
| In-frame | ENST00000429677 | ENST00000311737 | PRSS3 | chr9 | 33798080 | + | PRSS1 | chr7 | 142460281 | + |
| In-frame | ENST00000379405 | ENST00000486171 | PRSS3 | chr9 | 33798080 | + | PRSS1 | chr7 | 142460281 | + |
| In-frame | ENST00000379405 | ENST00000311737 | PRSS3 | chr9 | 33798080 | + | PRSS1 | chr7 | 142460281 | + |
| intron-3CDS | ENST00000495682 | ENST00000486171 | PRSS3 | chr9 | 33798080 | + | PRSS1 | chr7 | 142460281 | + |
| intron-3CDS | ENST00000495682 | ENST00000311737 | PRSS3 | chr9 | 33798080 | + | PRSS1 | chr7 | 142460281 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000361005 | PRSS3 | chr9 | 33798080 | + | ENST00000486171 | PRSS1 | chr7 | 142460281 | + | 915 | 625 | 0 | 914 | 304 |
| ENST00000361005 | PRSS3 | chr9 | 33798080 | + | ENST00000311737 | PRSS1 | chr7 | 142460281 | + | 965 | 625 | 0 | 914 | 304 |
| ENST00000342836 | PRSS3 | chr9 | 33798080 | + | ENST00000486171 | PRSS1 | chr7 | 142460281 | + | 870 | 580 | 84 | 869 | 261 |
| ENST00000342836 | PRSS3 | chr9 | 33798080 | + | ENST00000311737 | PRSS1 | chr7 | 142460281 | + | 920 | 580 | 84 | 869 | 261 |
| ENST00000429677 | PRSS3 | chr9 | 33798080 | + | ENST00000486171 | PRSS1 | chr7 | 142460281 | + | 736 | 446 | 13 | 735 | 241 |
| ENST00000429677 | PRSS3 | chr9 | 33798080 | + | ENST00000311737 | PRSS1 | chr7 | 142460281 | + | 786 | 446 | 13 | 735 | 240 |
| ENST00000379405 | PRSS3 | chr9 | 33798080 | + | ENST00000486171 | PRSS1 | chr7 | 142460281 | + | 783 | 493 | 39 | 782 | 247 |
| ENST00000379405 | PRSS3 | chr9 | 33798080 | + | ENST00000311737 | PRSS1 | chr7 | 142460281 | + | 833 | 493 | 39 | 782 | 247 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000361005 | ENST00000486171 | PRSS3 | chr9 | 33798080 | + | PRSS1 | chr7 | 142460281 | + | 0.012709568 | 0.98729044 |
| ENST00000361005 | ENST00000311737 | PRSS3 | chr9 | 33798080 | + | PRSS1 | chr7 | 142460281 | + | 0.013076814 | 0.98692316 |
| ENST00000342836 | ENST00000486171 | PRSS3 | chr9 | 33798080 | + | PRSS1 | chr7 | 142460281 | + | 0.008197259 | 0.99180275 |
| ENST00000342836 | ENST00000311737 | PRSS3 | chr9 | 33798080 | + | PRSS1 | chr7 | 142460281 | + | 0.010649003 | 0.989351 |
| ENST00000429677 | ENST00000486171 | PRSS3 | chr9 | 33798080 | + | PRSS1 | chr7 | 142460281 | + | 0.010967478 | 0.9890325 |
| ENST00000429677 | ENST00000311737 | PRSS3 | chr9 | 33798080 | + | PRSS1 | chr7 | 142460281 | + | 0.011521544 | 0.9884785 |
| ENST00000379405 | ENST00000486171 | PRSS3 | chr9 | 33798080 | + | PRSS1 | chr7 | 142460281 | + | 0.006896597 | 0.9931034 |
| ENST00000379405 | ENST00000311737 | PRSS3 | chr9 | 33798080 | + | PRSS1 | chr7 | 142460281 | + | 0.007874341 | 0.9921257 |
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Fusion Genomic Features for PRSS3-PRSS1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| PRSS3 | chr9 | 33798080 | + | PRSS1 | chr7 | 142460281 | + | 0.9459456 | 0.05405439 |
| PRSS3 | chr9 | 33798080 | + | PRSS1 | chr7 | 142460281 | + | 0.9459456 | 0.05405439 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for PRSS3-PRSS1 |
| Go to FGviewer for the breakpoints of chr9:33798080-chr7:142460281 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PRSS3 | chr9:33798080 | chr7:142460281 | ENST00000342836 | + | 4 | 6 | 81_301 | 165.33333333333334 | 262.0 | Domain | Peptidase S1 |
| Hgene | PRSS3 | chr9:33798080 | chr7:142460281 | ENST00000361005 | + | 3 | 5 | 81_301 | 208.33333333333334 | 305.0 | Domain | Peptidase S1 |
| Hgene | PRSS3 | chr9:33798080 | chr7:142460281 | ENST00000379405 | + | 3 | 5 | 81_301 | 151.33333333333334 | 248.0 | Domain | Peptidase S1 |
| Tgene | PRSS1 | chr9:33798080 | chr7:142460281 | ENST00000311737 | 2 | 5 | 24_244 | 151.33333333333334 | 248.0 | Domain | Peptidase S1 |
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Fusion Gene Sequence for PRSS3-PRSS1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000361005_ENST00000486171_203N_PRSS3_chr9_33798080_+_PRSS1_chr7_142460281_length(transcript)=915nt_BP=625nt ATGTGCGGACCTGACGACAGATGCCCCGCACGCTGGCCGGGACCGGGAAGGGCGGTCAAGTGTGGAAAGGGTCTGGCGGCTGCCAGGCCT GGCAGAGTGGAGCGGGGCGGGGCGCAGCGGGGCGGGGCGGGCCTGGAGCTGCACCCGCTTCTGGGTGGACGCACTTGGCGAGCGGCGCGG GATGCAGACGGCTGCGAGGCGCTGGGCACAGTTGCTGTCCCCTTTGACGATGATGACAAGATTGTTGGGGGCTACACCTGTGAGGAGAAT TCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTCTGCGGTGGCTCCCTCATCAGCGAACAGTGGGTGGTATCAGCAGCTCAC TGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAACATCAAAGTCCTGGAGGGGAATGAGCAGTTCATCAATGCGGCCAAGATC ATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGACATCATGCTGATCAAACTCTCCTCACCTGCCGTCATCAATGCCCGCGTG TCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACTGAGTGCCTCATCTCCGGCTGGGGCAACACTCTGAGCTTTGGTGCCGAC TACCCAGACGAGCTGCAGTGCCTGGATGCTCCTGTGCTGAGCCAGGCTAAGTGTGAAGCCTCCTACCCTGGAAAGATTACCAGCAACATG TTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCATGTCAGGGTGATTCTGGTGGCCCTGTGGTCTGCAATGGACAGCTCCAAGGAGTT GTCTCCTGGGGTGATGGCTGTGCCCAGAAGAACAAGCCTGGAGTCTACACCAAGGTCTACAACTATGTGAAATGGATTAAGAACACCATA >In-frame_ENST00000361005_ENST00000486171_203N_PRSS3_chr9_33798080_+_PRSS1_chr7_142460281_length(amino acids)=304AA_start in transcript=0_stop in transcript=914 MCGPDDRCPARWPGPGRAVKCGKGLAAARPGRVERGGAQRGGAGLELHPLLGGRTWRAARDADGCEALGTVAVPFDDDDKIVGGYTCEEN SLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARV STISLPTTPPAAGTECLISGWGNTLSFGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGV -------------------------------------------------------------- >In-frame_ENST00000361005_ENST00000311737_203N_PRSS3_chr9_33798080_+_PRSS1_chr7_142460281_length(transcript)=965nt_BP=625nt ATGTGCGGACCTGACGACAGATGCCCCGCACGCTGGCCGGGACCGGGAAGGGCGGTCAAGTGTGGAAAGGGTCTGGCGGCTGCCAGGCCT GGCAGAGTGGAGCGGGGCGGGGCGCAGCGGGGCGGGGCGGGCCTGGAGCTGCACCCGCTTCTGGGTGGACGCACTTGGCGAGCGGCGCGG GATGCAGACGGCTGCGAGGCGCTGGGCACAGTTGCTGTCCCCTTTGACGATGATGACAAGATTGTTGGGGGCTACACCTGTGAGGAGAAT TCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTCTGCGGTGGCTCCCTCATCAGCGAACAGTGGGTGGTATCAGCAGCTCAC TGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAACATCAAAGTCCTGGAGGGGAATGAGCAGTTCATCAATGCGGCCAAGATC ATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGACATCATGCTGATCAAACTCTCCTCACCTGCCGTCATCAATGCCCGCGTG TCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACTGAGTGCCTCATCTCCGGCTGGGGCAACACTCTGAGCTTTGGTGCCGAC TACCCAGACGAGCTGCAGTGCCTGGATGCTCCTGTGCTGAGCCAGGCTAAGTGTGAAGCCTCCTACCCTGGAAAGATTACCAGCAACATG TTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCATGTCAGGGTGATTCTGGTGGCCCTGTGGTCTGCAATGGACAGCTCCAAGGAGTT GTCTCCTGGGGTGATGGCTGTGCCCAGAAGAACAAGCCTGGAGTCTACACCAAGGTCTACAACTATGTGAAATGGATTAAGAACACCATA >In-frame_ENST00000361005_ENST00000311737_203N_PRSS3_chr9_33798080_+_PRSS1_chr7_142460281_length(amino acids)=304AA_start in transcript=0_stop in transcript=914 MCGPDDRCPARWPGPGRAVKCGKGLAAARPGRVERGGAQRGGAGLELHPLLGGRTWRAARDADGCEALGTVAVPFDDDDKIVGGYTCEEN SLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARV STISLPTTPPAAGTECLISGWGNTLSFGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGV -------------------------------------------------------------- >In-frame_ENST00000342836_ENST00000486171_203N_PRSS3_chr9_33798080_+_PRSS1_chr7_142460281_length(transcript)=870nt_BP=580nt GGCGCGGGATGCAGACGGCTGCGAGGCGCTGGGCACAGGTTGCCAGGACAACCGTGAGGCTGCATAAAAAGAACCTATGACAGGATGCAC ATGAGAGAGACAAGTGGCTTCACATTGAAGAAGGGGAGGAGTGCGCCATTGGTTTTCCATCCTCCAGATGCACTGATTGCTGTCCCCTTT GACGATGATGACAAGATTGTTGGGGGCTACACCTGTGAGGAGAATTCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTCTGC GGTGGCTCCCTCATCAGCGAACAGTGGGTGGTATCAGCAGCTCACTGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAACATC AAAGTCCTGGAGGGGAATGAGCAGTTCATCAATGCGGCCAAGATCATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGACATC ATGCTGATCAAACTCTCCTCACCTGCCGTCATCAATGCCCGCGTGTCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACTGAG TGCCTCATCTCCGGCTGGGGCAACACTCTGAGCTTTGGTGCCGACTACCCAGACGAGCTGCAGTGCCTGGATGCTCCTGTGCTGAGCCAG GCTAAGTGTGAAGCCTCCTACCCTGGAAAGATTACCAGCAACATGTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCATGTCAGGGT GATTCTGGTGGCCCTGTGGTCTGCAATGGACAGCTCCAAGGAGTTGTCTCCTGGGGTGATGGCTGTGCCCAGAAGAACAAGCCTGGAGTC >In-frame_ENST00000342836_ENST00000486171_203N_PRSS3_chr9_33798080_+_PRSS1_chr7_142460281_length(amino acids)=261AA_start in transcript=84_stop in transcript=869 MHMRETSGFTLKKGRSAPLVFHPPDALIAVPFDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEH NIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGADYPDELQCLDAPVL -------------------------------------------------------------- >In-frame_ENST00000342836_ENST00000311737_203N_PRSS3_chr9_33798080_+_PRSS1_chr7_142460281_length(transcript)=920nt_BP=580nt GGCGCGGGATGCAGACGGCTGCGAGGCGCTGGGCACAGGTTGCCAGGACAACCGTGAGGCTGCATAAAAAGAACCTATGACAGGATGCAC ATGAGAGAGACAAGTGGCTTCACATTGAAGAAGGGGAGGAGTGCGCCATTGGTTTTCCATCCTCCAGATGCACTGATTGCTGTCCCCTTT GACGATGATGACAAGATTGTTGGGGGCTACACCTGTGAGGAGAATTCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTCTGC GGTGGCTCCCTCATCAGCGAACAGTGGGTGGTATCAGCAGCTCACTGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAACATC AAAGTCCTGGAGGGGAATGAGCAGTTCATCAATGCGGCCAAGATCATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGACATC ATGCTGATCAAACTCTCCTCACCTGCCGTCATCAATGCCCGCGTGTCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACTGAG TGCCTCATCTCCGGCTGGGGCAACACTCTGAGCTTTGGTGCCGACTACCCAGACGAGCTGCAGTGCCTGGATGCTCCTGTGCTGAGCCAG GCTAAGTGTGAAGCCTCCTACCCTGGAAAGATTACCAGCAACATGTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCATGTCAGGGT GATTCTGGTGGCCCTGTGGTCTGCAATGGACAGCTCCAAGGAGTTGTCTCCTGGGGTGATGGCTGTGCCCAGAAGAACAAGCCTGGAGTC TACACCAAGGTCTACAACTATGTGAAATGGATTAAGAACACCATAGCTGCCAATAGCTAAAGCCCCCAGTATCTCTTCAGTCTCTATACC >In-frame_ENST00000342836_ENST00000311737_203N_PRSS3_chr9_33798080_+_PRSS1_chr7_142460281_length(amino acids)=261AA_start in transcript=84_stop in transcript=869 MHMRETSGFTLKKGRSAPLVFHPPDALIAVPFDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEH NIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGADYPDELQCLDAPVL -------------------------------------------------------------- >In-frame_ENST00000429677_ENST00000486171_203N_PRSS3_chr9_33798080_+_PRSS1_chr7_142460281_length(transcript)=736nt_BP=446nt GGTTCCGACTCGCATGGGACCTGCGGGGGAGGTTGCTGTCCCCTTTGACGATGATGACAAGATTGTTGGGGGCTACACCTGTGAGGAGAA TTCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTCTGCGGTGGCTCCCTCATCAGCGAACAGTGGGTGGTATCAGCAGCTCA CTGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAACATCAAAGTCCTGGAGGGGAATGAGCAGTTCATCAATGCGGCCAAGAT CATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGACATCATGCTGATCAAACTCTCCTCACCTGCCGTCATCAATGCCCGCGT GTCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACTGAGTGCCTCATCTCCGGCTGGGGCAACACTCTGAGCTTTGGTGCCGA CTACCCAGACGAGCTGCAGTGCCTGGATGCTCCTGTGCTGAGCCAGGCTAAGTGTGAAGCCTCCTACCCTGGAAAGATTACCAGCAACAT GTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCATGTCAGGGTGATTCTGGTGGCCCTGTGGTCTGCAATGGACAGCTCCAAGGAGT TGTCTCCTGGGGTGATGGCTGTGCCCAGAAGAACAAGCCTGGAGTCTACACCAAGGTCTACAACTATGTGAAATGGATTAAGAACACCAT >In-frame_ENST00000429677_ENST00000486171_203N_PRSS3_chr9_33798080_+_PRSS1_chr7_142460281_length(amino acids)=241AA_start in transcript=13_stop in transcript=735 MGPAGEVAVPFDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHP KYNRDTLDNDIMLIKLSSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVG -------------------------------------------------------------- >In-frame_ENST00000429677_ENST00000311737_203N_PRSS3_chr9_33798080_+_PRSS1_chr7_142460281_length(transcript)=786nt_BP=446nt GGTTCCGACTCGCATGGGACCTGCGGGGGAGGTTGCTGTCCCCTTTGACGATGATGACAAGATTGTTGGGGGCTACACCTGTGAGGAGAA TTCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTCTGCGGTGGCTCCCTCATCAGCGAACAGTGGGTGGTATCAGCAGCTCA CTGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAACATCAAAGTCCTGGAGGGGAATGAGCAGTTCATCAATGCGGCCAAGAT CATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGACATCATGCTGATCAAACTCTCCTCACCTGCCGTCATCAATGCCCGCGT GTCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACTGAGTGCCTCATCTCCGGCTGGGGCAACACTCTGAGCTTTGGTGCCGA CTACCCAGACGAGCTGCAGTGCCTGGATGCTCCTGTGCTGAGCCAGGCTAAGTGTGAAGCCTCCTACCCTGGAAAGATTACCAGCAACAT GTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCATGTCAGGGTGATTCTGGTGGCCCTGTGGTCTGCAATGGACAGCTCCAAGGAGT TGTCTCCTGGGGTGATGGCTGTGCCCAGAAGAACAAGCCTGGAGTCTACACCAAGGTCTACAACTATGTGAAATGGATTAAGAACACCAT >In-frame_ENST00000429677_ENST00000311737_203N_PRSS3_chr9_33798080_+_PRSS1_chr7_142460281_length(amino acids)=240AA_start in transcript=13_stop in transcript=735 MGPAGEVAVPFDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHP KYNRDTLDNDIMLIKLSSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVG -------------------------------------------------------------- >In-frame_ENST00000379405_ENST00000486171_203N_PRSS3_chr9_33798080_+_PRSS1_chr7_142460281_length(transcript)=783nt_BP=493nt GACAGGCCTTCCACCACCAGTCAGGCACACTCTACCACCATGAATCCATTCCTGATCCTTGCCTTTGTGGGAGCTGCTGTTGCTGTCCCC TTTGACGATGATGACAAGATTGTTGGGGGCTACACCTGTGAGGAGAATTCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTC TGCGGTGGCTCCCTCATCAGCGAACAGTGGGTGGTATCAGCAGCTCACTGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAAC ATCAAAGTCCTGGAGGGGAATGAGCAGTTCATCAATGCGGCCAAGATCATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGAC ATCATGCTGATCAAACTCTCCTCACCTGCCGTCATCAATGCCCGCGTGTCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACT GAGTGCCTCATCTCCGGCTGGGGCAACACTCTGAGCTTTGGTGCCGACTACCCAGACGAGCTGCAGTGCCTGGATGCTCCTGTGCTGAGC CAGGCTAAGTGTGAAGCCTCCTACCCTGGAAAGATTACCAGCAACATGTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCATGTCAG GGTGATTCTGGTGGCCCTGTGGTCTGCAATGGACAGCTCCAAGGAGTTGTCTCCTGGGGTGATGGCTGTGCCCAGAAGAACAAGCCTGGA >In-frame_ENST00000379405_ENST00000486171_203N_PRSS3_chr9_33798080_+_PRSS1_chr7_142460281_length(amino acids)=247AA_start in transcript=39_stop in transcript=782 MNPFLILAFVGAAVAVPFDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINA AKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGADYPDELQCLDAPVLSQAKCEASYPGKIT -------------------------------------------------------------- >In-frame_ENST00000379405_ENST00000311737_203N_PRSS3_chr9_33798080_+_PRSS1_chr7_142460281_length(transcript)=833nt_BP=493nt GACAGGCCTTCCACCACCAGTCAGGCACACTCTACCACCATGAATCCATTCCTGATCCTTGCCTTTGTGGGAGCTGCTGTTGCTGTCCCC TTTGACGATGATGACAAGATTGTTGGGGGCTACACCTGTGAGGAGAATTCTCTCCCCTACCAGGTGTCCCTGAATTCTGGCTCCCACTTC TGCGGTGGCTCCCTCATCAGCGAACAGTGGGTGGTATCAGCAGCTCACTGCTACAAGACCCGCATCCAGGTGAGACTGGGAGAGCACAAC ATCAAAGTCCTGGAGGGGAATGAGCAGTTCATCAATGCGGCCAAGATCATCCGCCACCCTAAATACAACAGGGACACTCTGGACAATGAC ATCATGCTGATCAAACTCTCCTCACCTGCCGTCATCAATGCCCGCGTGTCCACCATCTCTCTGCCCACCACCCCTCCAGCTGCTGGCACT GAGTGCCTCATCTCCGGCTGGGGCAACACTCTGAGCTTTGGTGCCGACTACCCAGACGAGCTGCAGTGCCTGGATGCTCCTGTGCTGAGC CAGGCTAAGTGTGAAGCCTCCTACCCTGGAAAGATTACCAGCAACATGTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCATGTCAG GGTGATTCTGGTGGCCCTGTGGTCTGCAATGGACAGCTCCAAGGAGTTGTCTCCTGGGGTGATGGCTGTGCCCAGAAGAACAAGCCTGGA GTCTACACCAAGGTCTACAACTATGTGAAATGGATTAAGAACACCATAGCTGCCAATAGCTAAAGCCCCCAGTATCTCTTCAGTCTCTAT >In-frame_ENST00000379405_ENST00000311737_203N_PRSS3_chr9_33798080_+_PRSS1_chr7_142460281_length(amino acids)=247AA_start in transcript=39_stop in transcript=782 MNPFLILAFVGAAVAVPFDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINA AKIIRHPKYNRDTLDNDIMLIKLSSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGADYPDELQCLDAPVLSQAKCEASYPGKIT -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for PRSS3-PRSS1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PRSS3-PRSS1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for PRSS3-PRSS1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PRSS3 | C0005684 | Malignant neoplasm of urinary bladder | 1 | CTD_human |
| Hgene | PRSS3 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Tgene | PRSS1 | C0238339 | Hereditary pancreatitis | 13 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| Tgene | PRSS1 | C0267937 | Acute recurrent pancreatitis | 2 | ORPHANET |
| Tgene | PRSS1 | C0030305 | Pancreatitis | 1 | CTD_human |
| Tgene | PRSS1 | C0149521 | Pancreatitis, Chronic | 1 | CTD_human |
| Tgene | PRSS1 | C4080064 | Autosomal Dominant Hereditary Pancreatitis | 1 | CTD_human |
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