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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PRUNE-ARNT (FusionGDB2 ID:68915)

Fusion Gene Summary for PRUNE-ARNT

check button Fusion gene summary
Fusion gene informationFusion gene name: PRUNE-ARNT
Fusion gene ID: 68915
HgeneTgene
Gene symbol

PRUNE

ARNT

Gene ID

58497

375056

Gene nameprune exopolyphosphatase 1MIA SH3 domain ER export factor 3
SynonymsDRES-17|DRES17|H-PRUNE|HTCD37|NMIHBA|PRUNEARNT|D320|TANGO|TANGO1|UNQ6077
Cytomap

1q21.3

1q41

Type of geneprotein-codingprotein-coding
Descriptionexopolyphosphatase PRUNE1Drosophila-related expressed sequence 17protein prune homologprotein prune homolog 1transport and Golgi organization protein 1 homologC219-reactive peptideMIA family member 3, ER export factormelanoma inhibitory activity family, member 3melanoma inhibitory activity protein 3transport and Golgi organization protein 1
Modification date2020031320200313
UniProtAcc.

Q8WYA1

Ensembl transtripts involved in fusion geneENST00000467771, ENST00000271620, 
ENST00000271619, ENST00000368937, 
ENST00000368936, ENST00000368935, 
ENST00000368934, 		ENST00000358595, 
ENST00000354396, ENST00000515192, 
ENST00000505755, ENST00000468970, 
Fusion gene scores* DoF score7 X 5 X 6=2109 X 6 X 6=324
# samples 89
** MAII scorelog2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/324*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRUNE [Title/Abstract] AND ARNT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPRUNE(150991145)-ARNT(150812130), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneARNT

GO:0002687

positive regulation of leukocyte migration

17726152

TgeneARNT

GO:0007162

negative regulation of cell adhesion

17726152

TgeneARNT

GO:0030336

negative regulation of cell migration

17044017

TgeneARNT

GO:0042060

wound healing

17044017


check buttonFusion gene breakpoints across PRUNE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ARNT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8284-01APRUNEchr1

150991145

+ARNTchr1

150812130

-


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Fusion Gene ORF analysis for PRUNE-ARNT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000467771ENST00000358595PRUNEchr1

150991145

+ARNTchr1

150812130

-
3UTR-3CDSENST00000467771ENST00000354396PRUNEchr1

150991145

+ARNTchr1

150812130

-
3UTR-3CDSENST00000467771ENST00000515192PRUNEchr1

150991145

+ARNTchr1

150812130

-
3UTR-3CDSENST00000467771ENST00000505755PRUNEchr1

150991145

+ARNTchr1

150812130

-
3UTR-intronENST00000467771ENST00000468970PRUNEchr1

150991145

+ARNTchr1

150812130

-
In-frameENST00000271620ENST00000358595PRUNEchr1

150991145

+ARNTchr1

150812130

-
In-frameENST00000271620ENST00000354396PRUNEchr1

150991145

+ARNTchr1

150812130

-
In-frameENST00000271620ENST00000515192PRUNEchr1

150991145

+ARNTchr1

150812130

-
In-frameENST00000271620ENST00000505755PRUNEchr1

150991145

+ARNTchr1

150812130

-
5CDS-intronENST00000271620ENST00000468970PRUNEchr1

150991145

+ARNTchr1

150812130

-
intron-3CDSENST00000271619ENST00000358595PRUNEchr1

150991145

+ARNTchr1

150812130

-
intron-3CDSENST00000271619ENST00000354396PRUNEchr1

150991145

+ARNTchr1

150812130

-
intron-3CDSENST00000271619ENST00000515192PRUNEchr1

150991145

+ARNTchr1

150812130

-
intron-3CDSENST00000271619ENST00000505755PRUNEchr1

150991145

+ARNTchr1

150812130

-
intron-intronENST00000271619ENST00000468970PRUNEchr1

150991145

+ARNTchr1

150812130

-
intron-3CDSENST00000368937ENST00000358595PRUNEchr1

150991145

+ARNTchr1

150812130

-
intron-3CDSENST00000368937ENST00000354396PRUNEchr1

150991145

+ARNTchr1

150812130

-
intron-3CDSENST00000368937ENST00000515192PRUNEchr1

150991145

+ARNTchr1

150812130

-
intron-3CDSENST00000368937ENST00000505755PRUNEchr1

150991145

+ARNTchr1

150812130

-
intron-intronENST00000368937ENST00000468970PRUNEchr1

150991145

+ARNTchr1

150812130

-
intron-3CDSENST00000368936ENST00000358595PRUNEchr1

150991145

+ARNTchr1

150812130

-
intron-3CDSENST00000368936ENST00000354396PRUNEchr1

150991145

+ARNTchr1

150812130

-
intron-3CDSENST00000368936ENST00000515192PRUNEchr1

150991145

+ARNTchr1

150812130

-
intron-3CDSENST00000368936ENST00000505755PRUNEchr1

150991145

+ARNTchr1

150812130

-
intron-intronENST00000368936ENST00000468970PRUNEchr1

150991145

+ARNTchr1

150812130

-
intron-3CDSENST00000368935ENST00000358595PRUNEchr1

150991145

+ARNTchr1

150812130

-
intron-3CDSENST00000368935ENST00000354396PRUNEchr1

150991145

+ARNTchr1

150812130

-
intron-3CDSENST00000368935ENST00000515192PRUNEchr1

150991145

+ARNTchr1

150812130

-
intron-3CDSENST00000368935ENST00000505755PRUNEchr1

150991145

+ARNTchr1

150812130

-
intron-intronENST00000368935ENST00000468970PRUNEchr1

150991145

+ARNTchr1

150812130

-
intron-3CDSENST00000368934ENST00000358595PRUNEchr1

150991145

+ARNTchr1

150812130

-
intron-3CDSENST00000368934ENST00000354396PRUNEchr1

150991145

+ARNTchr1

150812130

-
intron-3CDSENST00000368934ENST00000515192PRUNEchr1

150991145

+ARNTchr1

150812130

-
intron-3CDSENST00000368934ENST00000505755PRUNEchr1

150991145

+ARNTchr1

150812130

-
intron-intronENST00000368934ENST00000468970PRUNEchr1

150991145

+ARNTchr1

150812130

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000271620PRUNEchr1150991145+ENST00000358595ARNTchr1150812130-4905491602588842
ENST00000271620PRUNEchr1150991145+ENST00000354396ARNTchr1150812130-3745491602582840
ENST00000271620PRUNEchr1150991145+ENST00000515192ARNTchr1150812130-2914491602573837
ENST00000271620PRUNEchr1150991145+ENST00000505755ARNTchr1150812130-2649491602588842

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000271620ENST00000358595PRUNEchr1150991145+ARNTchr1150812130-0.0010342560.99896574
ENST00000271620ENST00000354396PRUNEchr1150991145+ARNTchr1150812130-0.0022165680.9977835
ENST00000271620ENST00000515192PRUNEchr1150991145+ARNTchr1150812130-0.0048479420.995152
ENST00000271620ENST00000505755PRUNEchr1150991145+ARNTchr1150812130-0.0078701840.99212974

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Fusion Genomic Features for PRUNE-ARNT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PRUNE-ARNT


check button Go to

FGviewer for the breakpoints of chr1:150991145-chr1:150812130

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ARNT

Q8WYA1

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. The CLOCK-ARNTL2/BMAL2 heterodimer activates the transcription of SERPINE1/PAI1 and BHLHE40/DEC1. {ECO:0000269|PubMed:11018023, ECO:0000269|PubMed:12738229, ECO:0000269|PubMed:14672706}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRUNEchr1:150991145chr1:150812130ENST00000271620+38106_108111.66666666666667454.0MotifNote=DHH motif
TgeneARNTchr1:150991145chr1:150812130ENST00000358595422503_50790.66666666666667790.0Compositional biasNote=Poly-Gln
TgeneARNTchr1:150991145chr1:150812130ENST00000358595422710_76990.66666666666667790.0Compositional biasNote=Gln-rich
TgeneARNTchr1:150991145chr1:150812130ENST00000358595422738_74190.66666666666667790.0Compositional biasNote=Poly-Ser
TgeneARNTchr1:150991145chr1:150812130ENST0000035859542299_10290.66666666666667790.0Compositional biasNote=Poly-Arg
TgeneARNTchr1:150991145chr1:150812130ENST00000505755321503_50775.66666666666667775.0Compositional biasNote=Poly-Gln
TgeneARNTchr1:150991145chr1:150812130ENST00000505755321710_76975.66666666666667775.0Compositional biasNote=Gln-rich
TgeneARNTchr1:150991145chr1:150812130ENST00000505755321738_74175.66666666666667775.0Compositional biasNote=Poly-Ser
TgeneARNTchr1:150991145chr1:150812130ENST0000050575532199_10275.66666666666667775.0Compositional biasNote=Poly-Arg
TgeneARNTchr1:150991145chr1:150812130ENST00000515192523503_50781.66666666666667776.0Compositional biasNote=Poly-Gln
TgeneARNTchr1:150991145chr1:150812130ENST00000515192523710_76981.66666666666667776.0Compositional biasNote=Gln-rich
TgeneARNTchr1:150991145chr1:150812130ENST00000515192523738_74181.66666666666667776.0Compositional biasNote=Poly-Ser
TgeneARNTchr1:150991145chr1:150812130ENST0000051519252399_10281.66666666666667776.0Compositional biasNote=Poly-Arg
TgeneARNTchr1:150991145chr1:150812130ENST00000358595422161_23590.66666666666667790.0DomainPAS 1
TgeneARNTchr1:150991145chr1:150812130ENST00000358595422349_41990.66666666666667790.0DomainPAS 2
TgeneARNTchr1:150991145chr1:150812130ENST00000358595422424_46790.66666666666667790.0DomainNote=PAC
TgeneARNTchr1:150991145chr1:150812130ENST0000035859542289_14290.66666666666667790.0DomainbHLH
TgeneARNTchr1:150991145chr1:150812130ENST00000505755321161_23575.66666666666667775.0DomainPAS 1
TgeneARNTchr1:150991145chr1:150812130ENST00000505755321349_41975.66666666666667775.0DomainPAS 2
TgeneARNTchr1:150991145chr1:150812130ENST00000505755321424_46775.66666666666667775.0DomainNote=PAC
TgeneARNTchr1:150991145chr1:150812130ENST0000050575532189_14275.66666666666667775.0DomainbHLH
TgeneARNTchr1:150991145chr1:150812130ENST00000515192523161_23581.66666666666667776.0DomainPAS 1
TgeneARNTchr1:150991145chr1:150812130ENST00000515192523349_41981.66666666666667776.0DomainPAS 2
TgeneARNTchr1:150991145chr1:150812130ENST00000515192523424_46781.66666666666667776.0DomainNote=PAC
TgeneARNTchr1:150991145chr1:150812130ENST0000051519252389_14281.66666666666667776.0DomainbHLH
TgeneARNTchr1:150991145chr1:150812130ENST00000358595422112_16890.66666666666667790.0RegionRequired for heterodimer formation with HIF1A
TgeneARNTchr1:150991145chr1:150812130ENST00000358595422112_26490.66666666666667790.0RegionRequired for heterodimer formation with EPAS1
TgeneARNTchr1:150991145chr1:150812130ENST00000358595422167_17190.66666666666667790.0RegionMediates the transcription activity and dimerization of the AHR:ARNT complex
TgeneARNTchr1:150991145chr1:150812130ENST0000035859542288_12890.66666666666667790.0RegionDNA-binding
TgeneARNTchr1:150991145chr1:150812130ENST00000505755321112_16875.66666666666667775.0RegionRequired for heterodimer formation with HIF1A
TgeneARNTchr1:150991145chr1:150812130ENST00000505755321112_26475.66666666666667775.0RegionRequired for heterodimer formation with EPAS1
TgeneARNTchr1:150991145chr1:150812130ENST00000505755321167_17175.66666666666667775.0RegionMediates the transcription activity and dimerization of the AHR:ARNT complex
TgeneARNTchr1:150991145chr1:150812130ENST0000050575532188_12875.66666666666667775.0RegionDNA-binding
TgeneARNTchr1:150991145chr1:150812130ENST00000515192523112_16881.66666666666667776.0RegionRequired for heterodimer formation with HIF1A
TgeneARNTchr1:150991145chr1:150812130ENST00000515192523112_26481.66666666666667776.0RegionRequired for heterodimer formation with EPAS1
TgeneARNTchr1:150991145chr1:150812130ENST00000515192523167_17181.66666666666667776.0RegionMediates the transcription activity and dimerization of the AHR:ARNT complex
TgeneARNTchr1:150991145chr1:150812130ENST0000051519252388_12881.66666666666667776.0RegionDNA-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRUNEchr1:150991145chr1:150812130ENST00000368934+14106_1080219.0MotifNote=DHH motif
HgenePRUNEchr1:150991145chr1:150812130ENST00000368935+14106_1080169.0MotifNote=DHH motif
HgenePRUNEchr1:150991145chr1:150812130ENST00000368936+17106_1080272.0MotifNote=DHH motif
HgenePRUNEchr1:150991145chr1:150812130ENST00000368937+14106_1080219.0MotifNote=DHH motif
HgenePRUNEchr1:150991145chr1:150812130ENST00000271620+38393_420111.66666666666667454.0RegionNote=Essential for homodimerization
HgenePRUNEchr1:150991145chr1:150812130ENST00000368934+14393_4200219.0RegionNote=Essential for homodimerization
HgenePRUNEchr1:150991145chr1:150812130ENST00000368935+14393_4200169.0RegionNote=Essential for homodimerization
HgenePRUNEchr1:150991145chr1:150812130ENST00000368936+17393_4200272.0RegionNote=Essential for homodimerization
HgenePRUNEchr1:150991145chr1:150812130ENST00000368937+14393_4200219.0RegionNote=Essential for homodimerization


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Fusion Gene Sequence for PRUNE-ARNT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000271620_ENST00000358595_TCGA-BR-8284-01A_PRUNE_chr1_150991145_+_ARNT_chr1_150812130_length(transcript)=4905nt_BP=491nt
GGAGGCCGATTCGCCGTGTGGCGGGTTCGAGTCCCGCCTCCTGACTCTGGCCTCTAGTCCCTGAGTCCCGGGCGGGCTGCATTCGTCGGG
GAAACCTCTCCTCGACCAGGGGCACCTCTACTCGACCAGGGGCGACGGCGTACTTTGGGCTTCATCATGGAGGACTACCTGCAGGGTTGT
CGAGCTGCTCTGCAGGAGTCCCGACCTCTACATGTTGTGCTGGGAAATGAAGCCTGTGATTTGGACTCCACAGTGTCTGCTCTTGCCCTG
GCTTTTTACCTAGCAAAGACAACTGAGGCTGAGGAAGTCTTTGTGCCAGTTTTAAATATAAAACGTTCTGAACTACCTCTGCGAGGTGAC
ATTGTCTTCTTTCTTCAGAAGGTTCATATTCCAGAGAGTATCTTGATTTTTCGGGATGAGATTGACCTCCATGCATTATACCAGGCTGGC
CAACTCACCCTCATCCTTGTCGACCATCATATCTTATCCAAGGAAAATCACAGTGAAATTGAACGGCGGCGACGGAACAAGATGACAGCC
TACATCACAGAACTGTCAGATATGGTACCCACCTGTAGTGCCCTGGCTCGAAAACCAGACAAGCTAACCATCTTACGCATGGCAGTTTCT
CACATGAAGTCCTTGCGGGGAACTGGCAACACATCCACTGATGGCTCCTATAAGCCGTCTTTCCTCACTGATCAGGAACTGAAACATTTG
ATCTTGGAGGCAGCAGATGGCTTTCTGTTTATTGTCTCATGTGAGACAGGCAGGGTGGTGTATGTGTCTGACTCCGTGACTCCTGTTTTG
AACCAGCCACAGTCTGAATGGTTTGGCAGCACACTCTATGATCAGGTGCACCCAGATGATGTGGATAAACTTCGTGAGCAGCTTTCCACT
TCAGAAAATGCCCTGACAGGGCGTATCCTGGATCTAAAGACTGGAACAGTGAAAAAGGAAGGTCAGCAGTCTTCCATGAGAATGTGTATG
GGCTCAAGGAGATCGTTTATTTGCCGAATGAGGTGTGGCAGTAGCTCTGTGGACCCAGTTTCTGTGAATAGGCTGAGCTTTGTGAGGAAC
AGATGCAGGAATGGACTTGGCTCTGTAAAGGATGGGGAACCTCACTTCGTGGTGGTCCACTGCACAGGCTACATCAAGGCCTGGCCCCCA
GCAGGTGTTTCCCTCCCAGATGATGACCCAGAGGCTGGCCAGGGAAGCAAGTTTTGCCTAGTGGCCATTGGCAGATTGCAGGTAACTAGT
TCTCCCAACTGTACAGACATGAGTAATGTTTGTCAACCAACAGAGTTCATCTCCCGACACAACATTGAGGGTATCTTCACTTTTGTGGAT
CACCGCTGTGTGGCTACTGTTGGCTACCAGCCACAGGAACTCTTAGGAAAGAATATTGTAGAATTCTGTCATCCTGAAGACCAGCAGCTT
CTAAGAGACAGCTTCCAACAGGTAGTGAAATTAAAAGGCCAAGTGCTGTCTGTCATGTTCCGGTTCCGGTCTAAGAACCAAGAATGGCTC
TGGATGAGAACCAGCTCCTTTACTTTCCAGAACCCTTACTCAGATGAAATTGAGTACATCATCTGTACCAACACCAATGTGAAGAACTCT
AGCCAAGAACCACGGCCTACACTCTCCAACACAATCCAGAGGCCACAACTAGGTCCCACAGCTAATTTACCCCTGGAGATGGGCTCAGGA
CAGCTGGCACCCAGGCAGCAGCAACAGCAAACAGAATTGGACATGGTACCAGGAAGAGATGGACTGGCCAGCTACAATCATTCCCAGGTG
GTTCAGCCTGTGACAACCACAGGACCAGAACACAGCAAGCCCCTTGAGAAGTCAGATGGTTTATTTGCCCAGGATAGAGATCCAAGATTT
TCAGAAATCTATCACAACATCAATGCGGATCAGAGTAAAGGCATCTCCTCCAGCACTGTCCCTGCCACCCAACAGCTATTCTCCCAGGGC
AACACATTCCCTCCTACCCCCCGGCCGGCAGAGAATTTCAGGAATAGTGGCCTAGCCCCTCCTGTAACCATTGTCCAGCCATCAGCTTCT
GCAGGACAGATGTTGGCCCAGATTTCCCGCCACTCCAACCCCACCCAAGGAGCAACCCCAACTTGGACCCCTACTACCCGCTCAGGCTTT
TCTGCCCAGCAGGTGGCTACCCAGGCTACTGCTAAGACTCGTACTTCCCAGTTTGGTGTGGGCAGCTTTCAGACTCCATCCTCCTTCAGC
TCCATGTCCCTCCCTGGTGCCCCAACTGCATCGCCTGGTGCTGCTGCCTACCCTAGTCTCACCAATCGTGGATCTAACTTTGCTCCTGAG
ACTGGACAGACTGCAGGACAATTCCAGACACGGACAGCAGAGGGTGTGGGTGTCTGGCCACAGTGGCAGGGCCAGCAGCCTCATCATCGT
TCAAGTTCTAGTGAGCAACATGTTCAACAACCGCCAGCACAGCAACCTGGCCAGCCTGAGGTCTTCCAGGAGATGCTGTCCATGCTGGGA
GATCAGAGCAACAGCTACAACAATGAAGAATTCCCTGATCTAACTATGTTTCCCCCCTTTTCAGAATAGAACTATTGGGGTGAGGATAAG
GGGTGGGGGAGAAAAAATCACTGTTTGTTTTTAAAAAGCAAATCTTTCTGTAAACAGAATAAAAGTTCCTCTCCCTTCCCTTCCCTCACC
CCTGACATGTACCCCCTTTCCCTTCTGGCTGTTCCCCTGCTCTGTTGCCTCTCTAAGGTAACATTTATAGAAGAAATGGAATGAATCTCC
AAGGCTTTTAGGACTGTCTGAAAATTTGAGGCTGGGTGAAGTTAAAACACCTTTCCTTATGTCTCCTGACCTGAAATTGTATAGTGTTGA
TTTGTGCTGAGATCAAGAGGCAGGTTAGAAGAACCTGACATCCACTGTTTGCCTTGGATAGTATGGCTTGTTTTTGGAAAGAAATTCTGA
AGAGAGTGGAGGAGAGGAGAAATGTCCTCATATTTGAGGACCATGAAACATTGTAGGTATATATGGGGCTTTAGCAAGTTTGAGCATAGG
CTCTTTTTGCTGCCTGTGAGCAGTCCCTCTGGAAAGAAACATGTGAGTAAGTGAGAGAGAGTGTGTGTGTATGTGTGTGTGTGTGTGTGT
GCGCACACATGCTTCTGTATTTCACTCTTTCTCCCTATTAGGGAGTTATGCAAAATTTGTCCCCGATTTTACCTTTGTCTTTCTGTGTAC
TTTTCAAAGAGTCCTAAGGAGTTAAATCTTCCAGGTATTTTCCACTTAGTATTGCAGCCAAAGAATATTTAAATAAACGTCTTTGCTGCG
CTTGCATCCATGCCCAGCCAATATACAACTGTAAAGCAAATATAGAAAGTCGGCTGTTGATACGATTGTCTGTTATCGAACACATTCAGT
GATAAAGCTGGGTTACTGCTGCTTTTGGTGCTCTCACCTTATCTGGAAGATCTGCAAACATTACCTAAATAGGCTGGCAAGATAAACACT
TTCTGGAACCCGAGACTTGGCCATAAAGATAATGCTGCATTTTTCTGTCAGAATCACATATGATGTGTGTTCTGTAGAGGTTATTTCTGC
ATGGAAACTCAACTTCTTGGATTAGCCGTCCCAGTGAAAATCCTCATTGTTGGAGTGTAAACCAAATACGAAGCCCTCTTGCAAAGTAGC
CTCTTTCATCCCATACTCAAAATACCCAGTTTAGCAAGCAACTGAGATTTAAGTCTCTCTGGCCCTAAGAGGTTTTTCCTCTTTGCTCCC
TCCAATCTTGAGATTGGGTTTTGCTTTAGAGTGCAAGTATCATAATTCCGTATGATAGATGGGGCCTGGACACCCATCTCAACAGGGTCA
CTTGGTAATTAACAATAGCCATATAAATGCGGATACAGGTTACTACCCTCACCCTTTACCTTCCTCAGGTAACAGTCGTAGATACCAGCT
TTTTTTTTTTTTTTTTTAAATTGGCTTTGGCCAGTAGCTAAAGTGCAAGACTGAATTAATGAGAAGATATATTAAATGTAGTCATAGGGG
ACTGAGGAGCAAGGGTGGCCTTGAAGAGGCCAAAGGAATGTCCATTTGCTGAGTTTCCCTTCCTTATGTCTCCAGTCTGGTGCCAGGTAG
TGGAGTAAAAAAGGAGACAGTTTATTTTTTTATTCTATGTGCACACTTACAGTATACATATATATTTATATCACAATTTACGAAACCAAA
AAGTTGAGTTTCCAATGGAACCCTTGTTTTTTAATAATCGACTTTTTAAATGTGATCAGGACTATAATATTGTACAGTTATTATAGGGCT
TTTGGGGAAGGGGAGGATAGCGAGAAGATGCTCTGGGGGTTTTGTTTTTGCTTTTCCTTCAGGGTTTTATTTTTGACTGTTTTGTTTTCT
TGTTGGCCATTTCTGTATTGCTGGCATCTGTGCTAAGCTTTACAGTGGCAAAAATAATGACATGTAGCAAAGATTTTCAAACAAAATATT
TTTTCCTTTTGTAAAATTTCTTGTGTTGTGTGATCTTGATTGCGGCTTTATCATTCCTTTCCAGTTCATAAACAACAGGCACCCACAACC
AGAGGAATCTATAGTTTAAGCTCCAGACATACAAACATAAGGCACATTGTGTCTTTAATTTCAGGAATCAGAAATCATAGGGTTCTGATC
ACATTGCACGCCTCCCCCCTCACTTGTCCTCCTGATCCTGACACATTCTGAGTAACATCAGCAGGAATGCTCTGACCATGAGGTGGGGGT
TTTGGGGTGGGCGTTGCCTGGGTTCTTGGGAGAGAGGGGAAGAGTCGGGACTTGAAAACCACTAGGGCACATCTGGATGCCTTCCCCCAG

>In-frame_ENST00000271620_ENST00000358595_TCGA-BR-8284-01A_PRUNE_chr1_150991145_+_ARNT_chr1_150812130_length(amino acids)=842AA_start in transcript=60_stop in transcript=2588
MSPGRAAFVGETSPRPGAPLLDQGRRRTLGFIMEDYLQGCRAALQESRPLHVVLGNEACDLDSTVSALALAFYLAKTTEAEEVFVPVLNI
KRSELPLRGDIVFFLQKVHIPESILIFRDEIDLHALYQAGQLTLILVDHHILSKENHSEIERRRRNKMTAYITELSDMVPTCSALARKPD
KLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDD
VDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVH
CTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIV
EFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQRPQLGPT
ANLPLEMGSGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSKPLEKSDGLFAQDRDPRFSEIYHNINADQSKGISSSTV
PATQQLFSQGNTFPPTPRPAENFRNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKTRTSQFGV
GSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAPETGQTAGQFQTRTAEGVGVWPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPE

--------------------------------------------------------------
>In-frame_ENST00000271620_ENST00000354396_TCGA-BR-8284-01A_PRUNE_chr1_150991145_+_ARNT_chr1_150812130_length(transcript)=3745nt_BP=491nt
GGAGGCCGATTCGCCGTGTGGCGGGTTCGAGTCCCGCCTCCTGACTCTGGCCTCTAGTCCCTGAGTCCCGGGCGGGCTGCATTCGTCGGG
GAAACCTCTCCTCGACCAGGGGCACCTCTACTCGACCAGGGGCGACGGCGTACTTTGGGCTTCATCATGGAGGACTACCTGCAGGGTTGT
CGAGCTGCTCTGCAGGAGTCCCGACCTCTACATGTTGTGCTGGGAAATGAAGCCTGTGATTTGGACTCCACAGTGTCTGCTCTTGCCCTG
GCTTTTTACCTAGCAAAGACAACTGAGGCTGAGGAAGTCTTTGTGCCAGTTTTAAATATAAAACGTTCTGAACTACCTCTGCGAGGTGAC
ATTGTCTTCTTTCTTCAGAAGGTTCATATTCCAGAGAGTATCTTGATTTTTCGGGATGAGATTGACCTCCATGCATTATACCAGGCTGGC
CAACTCACCCTCATCCTTGTCGACCATCATATCTTATCCAAGGAAAATCACAGTGAAATTGAACGGCGGCGACGGAACAAGATGACAGCC
TACATCACAGAACTGTCAGATATGGTACCCACCTGTAGTGCCCTGGCTCGAAAACCAGACAAGCTAACCATCTTACGCATGGCAGTTTCT
CACATGAAGTCCTTGCGGGGAACTGGCAACACATCCACTGATGGCTCCTATAAGCCGTCTTTCCTCACTGATCAGGAACTGAAACATTTG
ATCTTGGAGGCAGCAGATGGCTTTCTGTTTATTGTCTCATGTGAGACAGGCAGGGTGGTGTATGTGTCTGACTCCGTGACTCCTGTTTTG
AACCAGCCACAGTCTGAATGGTTTGGCAGCACACTCTATGATCAGGTGCACCCAGATGATGTGGATAAACTTCGTGAGCAGCTTTCCACT
TCAGAAAATGCCCTGACAGGGCGTATCCTGGATCTAAAGACTGGAACAGTGAAAAAGGAAGGTCAGCAGTCTTCCATGAGAATGTGTATG
GGCTCAAGGAGATCGTTTATTTGCCGAATGAGGTGTGGCAGTAGCTCTGTGGACCCAGTTTCTGTGAATAGGCTGAGCTTTGTGAGGAAC
AGATGCAGGAATGGACTTGGCTCTGTAAAGGATGGGGAACCTCACTTCGTGGTGGTCCACTGCACAGGCTACATCAAGGCCTGGCCCCCA
GCAGGTGTTTCCCTCCCAGATGATGACCCAGAGGCTGGCCAGGGAAGCAAGTTTTGCCTAGTGGCCATTGGCAGATTGCAGGTAACTAGT
TCTCCCAACTGTACAGACATGAGTAATGTTTGTCAACCAACAGAGTTCATCTCCCGACACAACATTGAGGGTATCTTCACTTTTGTGGAT
CACCGCTGTGTGGCTACTGTTGGCTACCAGCCACAGGAACTCTTAGGAAAGAATATTGTAGAATTCTGTCATCCTGAAGACCAGCAGCTT
CTAAGAGACAGCTTCCAACAGGTAGTGAAATTAAAAGGCCAAGTGCTGTCTGTCATGTTCCGGTTCCGGTCTAAGAACCAAGAATGGCTC
TGGATGAGAACCAGCTCCTTTACTTTCCAGAACCCTTACTCAGATGAAATTGAGTACATCATCTGTACCAACACCAATGTGAAGAACTCT
AGCCAAGAACCACGGCCTACACTCTCCAACACAATCCAGAGGCCACAACTAGGTCCCACAGCTAATTTACCCCTGGAGATGGGCTCAGGA
CAGCTGGCACCCAGGCAGCAGCAACAGCAAACAGAATTGGACATGGTACCAGGAAGAGATGGACTGGCCAGCTACAATCATTCCCAGGTG
GTTCAGCCTGTGACAACCACAGGACCAGAACACAGCAAGCCCCTTGAGAAGTCAGATGGTTTATTTGCCCAGGATAGAGATCCAAGATTT
TCAGAAATCTATCACAACATCAATGCGGATCAGAGTAAAGGCATCTCCTCCAGCACTGTCCCTGCCACCCAACAGCTATTCTCCCAGGGC
AACACATTCCCTCCTACCCCCCGGCCGGCAGAGAATTTCAGTGGCCTAGCCCCTCCTGTAACCATTGTCCAGCCATCAGCTTCTGCAGGA
CAGATGTTGGCCCAGATTTCCCGCCACTCCAACCCCACCCAAGGAGCAACCCCAACTTGGACCCCTACTACCCGCTCAGGCTTTTCTGCC
CAGCAGGTGGCTACCCAGGCTACTGCTAAGACTCGTACTTCCCAGTTTGGTGTGGGCAGCTTTCAGACTCCATCCTCCTTCAGCTCCATG
TCCCTCCCTGGTGCCCCAACTGCATCGCCTGGTGCTGCTGCCTACCCTAGTCTCACCAATCGTGGATCTAACTTTGCTCCTGAGACTGGA
CAGACTGCAGGACAATTCCAGACACGGACAGCAGAGGGTGTGGGTGTCTGGCCACAGTGGCAGGGCCAGCAGCCTCATCATCGTTCAAGT
TCTAGTGAGCAACATGTTCAACAACCGCCAGCACAGCAACCTGGCCAGCCTGAGGTCTTCCAGGAGATGCTGTCCATGCTGGGAGATCAG
AGCAACAGCTACAACAATGAAGAATTCCCTGATCTAACTATGTTTCCCCCCTTTTCAGAATAGAACTATTGGGGTGAGGATAAGGGGTGG
GGGAGAAAAAATCACTGTTTGTTTTTAAAAAGCAAATCTTTCTGTAAACAGAATAAAAGTTCCTCTCCCTTCCCTTCCCTCACCCCTGAC
ATGTACCCCCTTTCCCTTCTGGCTGTTCCCCTGCTCTGTTGCCTCTCTAAGGTAACATTTATAGAAGAAATGGAATGAATCTCCAAGGCT
TTTAGGACTGTCTGAAAATTTGAGGCTGGGTGAAGTTAAAACACCTTTCCTTATGTCTCCTGACCTGAAATTGTATAGTGTTGATTTGTG
CTGAGATCAAGAGGCAGGTTAGAAGAACCTGACATCCACTGTTTGCCTTGGATAGTATGGCTTGTTTTTGGAAAGAAATTCTGAAGAGAG
TGGAGGAGAGGAGAAATGTCCTCATATTTGAGGACCATGAAACATTGTAGGTATATATGGGGCTTTAGCAAGTTTGAGCATAGGCTCTTT
TTGCTGCCTGTGAGCAGTCCCTCTGGAAAGAAACATGTGAGTAAGTGAGAGAGAGTGTGTGTGTATGTGTGTGTGTGTGTGTGTGCGCAC
ACATGCTTCTGTATTTCACTCTTTCTCCCTATTAGGGAGTTATGCAAAATTTGTCCCCGATTTTACCTTTGTCTTTCTGTGTACTTTTCA
AAGAGTCCTAAGGAGTTAAATCTTCCAGGTATTTTCCACTTAGTATTGCAGCCAAAGAATATTTAAATAAACGTCTTTGCTGCGCTTGCA
TCCATGCCCAGCCAATATACAACTGTAAAGCAAATATAGAAAGTCGGCTGTTGATACGATTGTCTGTTATCGAACACATTCAGTGATAAA
GCTGGGTTACTGCTGCTTTTGGTGCTCTCACCTTATCTGGAAGATCTGCAAACATTACCTAAATAGGCTGGCAAGATAAACACTTTCTGG
AACCCGAGACTTGGCCATAAAGATAATGCTGCATTTTTCTGTCAGAATCACATATGATGTGTGTTCTGTAGAGGTTATTTCTGCATGGAA
ACTCAACTTCTTGGATTAGCCGTCCCAGTGAAAATCCTCATTGTTGGAGTGTAAACCAAATACGAAGCCCTCTTGCAAAGTAGCCTCTTT

>In-frame_ENST00000271620_ENST00000354396_TCGA-BR-8284-01A_PRUNE_chr1_150991145_+_ARNT_chr1_150812130_length(amino acids)=840AA_start in transcript=60_stop in transcript=2582
MSPGRAAFVGETSPRPGAPLLDQGRRRTLGFIMEDYLQGCRAALQESRPLHVVLGNEACDLDSTVSALALAFYLAKTTEAEEVFVPVLNI
KRSELPLRGDIVFFLQKVHIPESILIFRDEIDLHALYQAGQLTLILVDHHILSKENHSEIERRRRNKMTAYITELSDMVPTCSALARKPD
KLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDD
VDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVH
CTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIV
EFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQRPQLGPT
ANLPLEMGSGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSKPLEKSDGLFAQDRDPRFSEIYHNINADQSKGISSSTV
PATQQLFSQGNTFPPTPRPAENFSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKTRTSQFGVGS
FQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAPETGQTAGQFQTRTAEGVGVWPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVF

--------------------------------------------------------------
>In-frame_ENST00000271620_ENST00000515192_TCGA-BR-8284-01A_PRUNE_chr1_150991145_+_ARNT_chr1_150812130_length(transcript)=2914nt_BP=491nt
GGAGGCCGATTCGCCGTGTGGCGGGTTCGAGTCCCGCCTCCTGACTCTGGCCTCTAGTCCCTGAGTCCCGGGCGGGCTGCATTCGTCGGG
GAAACCTCTCCTCGACCAGGGGCACCTCTACTCGACCAGGGGCGACGGCGTACTTTGGGCTTCATCATGGAGGACTACCTGCAGGGTTGT
CGAGCTGCTCTGCAGGAGTCCCGACCTCTACATGTTGTGCTGGGAAATGAAGCCTGTGATTTGGACTCCACAGTGTCTGCTCTTGCCCTG
GCTTTTTACCTAGCAAAGACAACTGAGGCTGAGGAAGTCTTTGTGCCAGTTTTAAATATAAAACGTTCTGAACTACCTCTGCGAGGTGAC
ATTGTCTTCTTTCTTCAGAAGGTTCATATTCCAGAGAGTATCTTGATTTTTCGGGATGAGATTGACCTCCATGCATTATACCAGGCTGGC
CAACTCACCCTCATCCTTGTCGACCATCATATCTTATCCAAGGAAAATCACAGTGAAATTGAACGGCGGCGACGGAACAAGATGACAGCC
TACATCACAGAACTGTCAGATATGGTACCCACCTGTAGTGCCCTGGCTCGAAAACCAGACAAGCTAACCATCTTACGCATGGCAGTTTCT
CACATGAAGTCCTTGCGGGGAACTGGCAACACATCCACTGATGGCTCCTATAAGCCGTCTTTCCTCACTGATCAGGAACTGAAACATTTG
ATCTTGGAGGCAGCAGATGGCTTTCTGTTTATTGTCTCATGTGAGACAGGCAGGGTGGTGTATGTGTCTGACTCCGTGACTCCTGTTTTG
AACCAGCCACAGTCTGAATGGTTTGGCAGCACACTCTATGATCAGGTGCACCCAGATGATGTGGATAAACTTCGTGAGCAGCTTTCCACT
TCAGAAAATGCCCTGACAGGGCGTATCCTGGATCTAAAGACTGGAACAGTGAAAAAGGAAGGTCAGCAGTCTTCCATGAGAATGTGTATG
GGCTCAAGGAGATCGTTTATTTGCCGAATGAGGTGTGGCAGTAGCTCTGTGGACCCAGTTTCTGTGAATAGGCTGAGCTTTGTGAGGAAC
AGATGCAGGAATGGACTTGGCTCTGTAAAGGATGGGGAACCTCACTTCGTGGTGGTCCACTGCACAGGCTACATCAAGGCCTGGCCCCCA
GCAGATGATGACCCAGAGGCTGGCCAGGGAAGCAAGTTTTGCCTAGTGGCCATTGGCAGATTGCAGGTAACTAGTTCTCCCAACTGTACA
GACATGAGTAATGTTTGTCAACCAACAGAGTTCATCTCCCGACACAACATTGAGGGTATCTTCACTTTTGTGGATCACCGCTGTGTGGCT
ACTGTTGGCTACCAGCCACAGGAACTCTTAGGAAAGAATATTGTAGAATTCTGTCATCCTGAAGACCAGCAGCTTCTAAGAGACAGCTTC
CAACAGGTAGTGAAATTAAAAGGCCAAGTGCTGTCTGTCATGTTCCGGTTCCGGTCTAAGAACCAAGAATGGCTCTGGATGAGAACCAGC
TCCTTTACTTTCCAGAACCCTTACTCAGATGAAATTGAGTACATCATCTGTACCAACACCAATGTGAAGAACTCTAGCCAAGAACCACGG
CCTACACTCTCCAACACAATCCAGAGGCCACAACTAGGTCCCACAGCTAATTTACCCCTGGAGATGGGCTCAGGACAGCTGGCACCCAGG
CAGCAGCAACAGCAAACAGAATTGGACATGGTACCAGGAAGAGATGGACTGGCCAGCTACAATCATTCCCAGGTGGTTCAGCCTGTGACA
ACCACAGGACCAGAACACAGCAAGCCCCTTGAGAAGTCAGATGGTTTATTTGCCCAGGATAGAGATCCAAGATTTTCAGAAATCTATCAC
AACATCAATGCGGATCAGAGTAAAGGCATCTCCTCCAGCACTGTCCCTGCCACCCAACAGCTATTCTCCCAGGGCAACACATTCCCTCCT
ACCCCCCGGCCGGCAGAGAATTTCAGGAATAGTGGCCTAGCCCCTCCTGTAACCATTGTCCAGCCATCAGCTTCTGCAGGACAGATGTTG
GCCCAGATTTCCCGCCACTCCAACCCCACCCAAGGAGCAACCCCAACTTGGACCCCTACTACCCGCTCAGGCTTTTCTGCCCAGCAGGTG
GCTACCCAGGCTACTGCTAAGACTCGTACTTCCCAGTTTGGTGTGGGCAGCTTTCAGACTCCATCCTCCTTCAGCTCCATGTCCCTCCCT
GGTGCCCCAACTGCATCGCCTGGTGCTGCTGCCTACCCTAGTCTCACCAATCGTGGATCTAACTTTGCTCCTGAGACTGGACAGACTGCA
GGACAATTCCAGACACGGACAGCAGAGGGTGTGGGTGTCTGGCCACAGTGGCAGGGCCAGCAGCCTCATCATCGTTCAAGTTCTAGTGAG
CAACATGTTCAACAACCGCCAGCACAGCAACCTGGCCAGCCTGAGGTCTTCCAGGAGATGCTGTCCATGCTGGGAGATCAGAGCAACAGC
TACAACAATGAAGAATTCCCTGATCTAACTATGTTTCCCCCCTTTTCAGAATAGAACTATTGGGGTGAGGATAAGGGGTGGGGGAGAAAA
AATCACTGTTTGTTTTTAAAAAGCAAATCTTTCTGTAAACAGAATAAAAGTTCCTCTCCCTTCCCTTCCCTCACCCCTGACATGTACCCC
CTTTCCCTTCTGGCTGTTCCCCTGCTCTGTTGCCTCTCTAAGGTAACATTTATAGAAGAAATGGAATGAATCTCCAAGGCTTTTAGGACT
GTCTGAAAATTTGAGGCTGGGTGAAGTTAAAACACCTTTCCTTATGTCTCCTGACCTGAAATTGTATAGTGTTGATTTGTGCTGAGATCA

>In-frame_ENST00000271620_ENST00000515192_TCGA-BR-8284-01A_PRUNE_chr1_150991145_+_ARNT_chr1_150812130_length(amino acids)=837AA_start in transcript=60_stop in transcript=2573
MSPGRAAFVGETSPRPGAPLLDQGRRRTLGFIMEDYLQGCRAALQESRPLHVVLGNEACDLDSTVSALALAFYLAKTTEAEEVFVPVLNI
KRSELPLRGDIVFFLQKVHIPESILIFRDEIDLHALYQAGQLTLILVDHHILSKENHSEIERRRRNKMTAYITELSDMVPTCSALARKPD
KLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDD
VDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVH
CTGYIKAWPPADDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHP
EDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQRPQLGPTANLPL
EMGSGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSKPLEKSDGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQ
LFSQGNTFPPTPRPAENFRNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKTRTSQFGVGSFQT
PSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAPETGQTAGQFQTRTAEGVGVWPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEM

--------------------------------------------------------------
>In-frame_ENST00000271620_ENST00000505755_TCGA-BR-8284-01A_PRUNE_chr1_150991145_+_ARNT_chr1_150812130_length(transcript)=2649nt_BP=491nt
GGAGGCCGATTCGCCGTGTGGCGGGTTCGAGTCCCGCCTCCTGACTCTGGCCTCTAGTCCCTGAGTCCCGGGCGGGCTGCATTCGTCGGG
GAAACCTCTCCTCGACCAGGGGCACCTCTACTCGACCAGGGGCGACGGCGTACTTTGGGCTTCATCATGGAGGACTACCTGCAGGGTTGT
CGAGCTGCTCTGCAGGAGTCCCGACCTCTACATGTTGTGCTGGGAAATGAAGCCTGTGATTTGGACTCCACAGTGTCTGCTCTTGCCCTG
GCTTTTTACCTAGCAAAGACAACTGAGGCTGAGGAAGTCTTTGTGCCAGTTTTAAATATAAAACGTTCTGAACTACCTCTGCGAGGTGAC
ATTGTCTTCTTTCTTCAGAAGGTTCATATTCCAGAGAGTATCTTGATTTTTCGGGATGAGATTGACCTCCATGCATTATACCAGGCTGGC
CAACTCACCCTCATCCTTGTCGACCATCATATCTTATCCAAGGAAAATCACAGTGAAATTGAACGGCGGCGACGGAACAAGATGACAGCC
TACATCACAGAACTGTCAGATATGGTACCCACCTGTAGTGCCCTGGCTCGAAAACCAGACAAGCTAACCATCTTACGCATGGCAGTTTCT
CACATGAAGTCCTTGCGGGGAACTGGCAACACATCCACTGATGGCTCCTATAAGCCGTCTTTCCTCACTGATCAGGAACTGAAACATTTG
ATCTTGGAGGCAGCAGATGGCTTTCTGTTTATTGTCTCATGTGAGACAGGCAGGGTGGTGTATGTGTCTGACTCCGTGACTCCTGTTTTG
AACCAGCCACAGTCTGAATGGTTTGGCAGCACACTCTATGATCAGGTGCACCCAGATGATGTGGATAAACTTCGTGAGCAGCTTTCCACT
TCAGAAAATGCCCTGACAGGGCGTATCCTGGATCTAAAGACTGGAACAGTGAAAAAGGAAGGTCAGCAGTCTTCCATGAGAATGTGTATG
GGCTCAAGGAGATCGTTTATTTGCCGAATGAGGTGTGGCAGTAGCTCTGTGGACCCAGTTTCTGTGAATAGGCTGAGCTTTGTGAGGAAC
AGATGCAGGAATGGACTTGGCTCTGTAAAGGATGGGGAACCTCACTTCGTGGTGGTCCACTGCACAGGCTACATCAAGGCCTGGCCCCCA
GCAGGTGTTTCCCTCCCAGATGATGACCCAGAGGCTGGCCAGGGAAGCAAGTTTTGCCTAGTGGCCATTGGCAGATTGCAGGTAACTAGT
TCTCCCAACTGTACAGACATGAGTAATGTTTGTCAACCAACAGAGTTCATCTCCCGACACAACATTGAGGGTATCTTCACTTTTGTGGAT
CACCGCTGTGTGGCTACTGTTGGCTACCAGCCACAGGAACTCTTAGGAAAGAATATTGTAGAATTCTGTCATCCTGAAGACCAGCAGCTT
CTAAGAGACAGCTTCCAACAGGTAGTGAAATTAAAAGGCCAAGTGCTGTCTGTCATGTTCCGGTTCCGGTCTAAGAACCAAGAATGGCTC
TGGATGAGAACCAGCTCCTTTACTTTCCAGAACCCTTACTCAGATGAAATTGAGTACATCATCTGTACCAACACCAATGTGAAGAACTCT
AGCCAAGAACCACGGCCTACACTCTCCAACACAATCCAGAGGCCACAACTAGGTCCCACAGCTAATTTACCCCTGGAGATGGGCTCAGGA
CAGCTGGCACCCAGGCAGCAGCAACAGCAAACAGAATTGGACATGGTACCAGGAAGAGATGGACTGGCCAGCTACAATCATTCCCAGGTG
GTTCAGCCTGTGACAACCACAGGACCAGAACACAGCAAGCCCCTTGAGAAGTCAGATGGTTTATTTGCCCAGGATAGAGATCCAAGATTT
TCAGAAATCTATCACAACATCAATGCGGATCAGAGTAAAGGCATCTCCTCCAGCACTGTCCCTGCCACCCAACAGCTATTCTCCCAGGGC
AACACATTCCCTCCTACCCCCCGGCCGGCAGAGAATTTCAGGAATAGTGGCCTAGCCCCTCCTGTAACCATTGTCCAGCCATCAGCTTCT
GCAGGACAGATGTTGGCCCAGATTTCCCGCCACTCCAACCCCACCCAAGGAGCAACCCCAACTTGGACCCCTACTACCCGCTCAGGCTTT
TCTGCCCAGCAGGTGGCTACCCAGGCTACTGCTAAGACTCGTACTTCCCAGTTTGGTGTGGGCAGCTTTCAGACTCCATCCTCCTTCAGC
TCCATGTCCCTCCCTGGTGCCCCAACTGCATCGCCTGGTGCTGCTGCCTACCCTAGTCTCACCAATCGTGGATCTAACTTTGCTCCTGAG
ACTGGACAGACTGCAGGACAATTCCAGACACGGACAGCAGAGGGTGTGGGTGTCTGGCCACAGTGGCAGGGCCAGCAGCCTCATCATCGT
TCAAGTTCTAGTGAGCAACATGTTCAACAACCGCCAGCACAGCAACCTGGCCAGCCTGAGGTCTTCCAGGAGATGCTGTCCATGCTGGGA
GATCAGAGCAACAGCTACAACAATGAAGAATTCCCTGATCTAACTATGTTTCCCCCCTTTTCAGAATAGAACTATTGGGGTGAGGATAAG

>In-frame_ENST00000271620_ENST00000505755_TCGA-BR-8284-01A_PRUNE_chr1_150991145_+_ARNT_chr1_150812130_length(amino acids)=842AA_start in transcript=60_stop in transcript=2588
MSPGRAAFVGETSPRPGAPLLDQGRRRTLGFIMEDYLQGCRAALQESRPLHVVLGNEACDLDSTVSALALAFYLAKTTEAEEVFVPVLNI
KRSELPLRGDIVFFLQKVHIPESILIFRDEIDLHALYQAGQLTLILVDHHILSKENHSEIERRRRNKMTAYITELSDMVPTCSALARKPD
KLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDD
VDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVH
CTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIV
EFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQRPQLGPT
ANLPLEMGSGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSKPLEKSDGLFAQDRDPRFSEIYHNINADQSKGISSSTV
PATQQLFSQGNTFPPTPRPAENFRNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKTRTSQFGV
GSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAPETGQTAGQFQTRTAEGVGVWPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PRUNE-ARNT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PRUNE-ARNT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PRUNE-ARNT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneARNTC0000786Spontaneous abortion1CTD_human
TgeneARNTC0000822Abortion, Tubal1CTD_human
TgeneARNTC0009402Colorectal Carcinoma1CTD_human
TgeneARNTC0009404Colorectal Neoplasms1CTD_human
TgeneARNTC0014175Endometriosis1CTD_human
TgeneARNTC0019193Hepatitis, Toxic1CTD_human
TgeneARNTC0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
TgeneARNTC0023453L2 Acute Lymphoblastic Leukemia1CTD_human
TgeneARNTC0023890Liver Cirrhosis1CTD_human
TgeneARNTC0025202melanoma1CTD_human
TgeneARNTC0027659Neoplasms, Experimental1CTD_human
TgeneARNTC0239946Fibrosis, Liver1CTD_human
TgeneARNTC0269102Endometrioma1CTD_human
TgeneARNTC0860207Drug-Induced Liver Disease1CTD_human
TgeneARNTC1262760Hepatitis, Drug-Induced1CTD_human
TgeneARNTC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneARNTC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneARNTC3830362Early Pregnancy Loss1CTD_human
TgeneARNTC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneARNTC4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneARNTC4552766Miscarriage1CTD_human