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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PSMC5-PSMC5 (FusionGDB2 ID:69194)

Fusion Gene Summary for PSMC5-PSMC5

check button Fusion gene summary
Fusion gene informationFusion gene name: PSMC5-PSMC5
Fusion gene ID: 69194
HgeneTgene
Gene symbol

PSMC5

PSMC5

Gene ID

5705

5705

Gene nameproteasome 26S subunit, ATPase 5proteasome 26S subunit, ATPase 5
SynonymsS8|SUG-1|SUG1|TBP10|TRIP1|p45|p45/SUGS8|SUG-1|SUG1|TBP10|TRIP1|p45|p45/SUG
Cytomap

17q23.3

17q23.3

Type of geneprotein-codingprotein-coding
Description26S proteasome regulatory subunit 826S protease regulatory subunit 826S proteasome AAA-ATPase subunit RPT6MSUG1 proteinTat-binding protein homolog 10proteasome (prosome, macropain) 26S subunit, ATPase, 5proteasome 26S ATPase subunit 5proteasome sub26S proteasome regulatory subunit 826S protease regulatory subunit 826S proteasome AAA-ATPase subunit RPT6MSUG1 proteinTat-binding protein homolog 10proteasome (prosome, macropain) 26S subunit, ATPase, 5proteasome 26S ATPase subunit 5proteasome sub
Modification date2020032720200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000310144, ENST00000582420, 
ENST00000580864, ENST00000375812, 
ENST00000581882, 		ENST00000310144, 
ENST00000582420, ENST00000580864, 
ENST00000375812, ENST00000581882, 
Fusion gene scores* DoF score7 X 8 X 1=561 X 2 X 1=2
# samples 82
** MAII scorelog2(8/56*10)=0.514573172829758
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/2*10)=3.32192809488736
Context

PubMed: PSMC5 [Title/Abstract] AND PSMC5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPSMC5(61909140)-PSMC5(61909339), # samples:1
PSMC5(61908502)-PSMC5(61908776), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePSMC5

GO:0006357

regulation of transcription by RNA polymerase II

7870181

HgenePSMC5

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

12110588

TgenePSMC5

GO:0006357

regulation of transcription by RNA polymerase II

7870181

TgenePSMC5

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

12110588


check buttonFusion gene breakpoints across PSMC5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PSMC5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABI002868PSMC5chr17

61909140

+PSMC5chr17

61909339

-
ChiTaRS5.0N/ACV422250PSMC5chr17

61908502

+PSMC5chr17

61908776

-


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Fusion Gene ORF analysis for PSMC5-PSMC5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000310144ENST00000310144PSMC5chr17

61909140

+PSMC5chr17

61909339

-
5CDS-intronENST00000310144ENST00000582420PSMC5chr17

61909140

+PSMC5chr17

61909339

-
5CDS-3UTRENST00000310144ENST00000580864PSMC5chr17

61909140

+PSMC5chr17

61909339

-
5CDS-3UTRENST00000310144ENST00000375812PSMC5chr17

61909140

+PSMC5chr17

61909339

-
5CDS-3UTRENST00000310144ENST00000581882PSMC5chr17

61909140

+PSMC5chr17

61909339

-
intron-3UTRENST00000582420ENST00000310144PSMC5chr17

61909140

+PSMC5chr17

61909339

-
intron-intronENST00000582420ENST00000582420PSMC5chr17

61909140

+PSMC5chr17

61909339

-
intron-3UTRENST00000582420ENST00000580864PSMC5chr17

61909140

+PSMC5chr17

61909339

-
intron-3UTRENST00000582420ENST00000375812PSMC5chr17

61909140

+PSMC5chr17

61909339

-
intron-3UTRENST00000582420ENST00000581882PSMC5chr17

61909140

+PSMC5chr17

61909339

-
5CDS-3UTRENST00000580864ENST00000310144PSMC5chr17

61909140

+PSMC5chr17

61909339

-
5CDS-intronENST00000580864ENST00000582420PSMC5chr17

61909140

+PSMC5chr17

61909339

-
5CDS-3UTRENST00000580864ENST00000580864PSMC5chr17

61909140

+PSMC5chr17

61909339

-
5CDS-3UTRENST00000580864ENST00000375812PSMC5chr17

61909140

+PSMC5chr17

61909339

-
5CDS-3UTRENST00000580864ENST00000581882PSMC5chr17

61909140

+PSMC5chr17

61909339

-
5CDS-3UTRENST00000375812ENST00000310144PSMC5chr17

61909140

+PSMC5chr17

61909339

-
5CDS-intronENST00000375812ENST00000582420PSMC5chr17

61909140

+PSMC5chr17

61909339

-
5CDS-3UTRENST00000375812ENST00000580864PSMC5chr17

61909140

+PSMC5chr17

61909339

-
5CDS-3UTRENST00000375812ENST00000375812PSMC5chr17

61909140

+PSMC5chr17

61909339

-
5CDS-3UTRENST00000375812ENST00000581882PSMC5chr17

61909140

+PSMC5chr17

61909339

-
5CDS-3UTRENST00000581882ENST00000310144PSMC5chr17

61909140

+PSMC5chr17

61909339

-
5CDS-intronENST00000581882ENST00000582420PSMC5chr17

61909140

+PSMC5chr17

61909339

-
5CDS-3UTRENST00000581882ENST00000580864PSMC5chr17

61909140

+PSMC5chr17

61909339

-
5CDS-3UTRENST00000581882ENST00000375812PSMC5chr17

61909140

+PSMC5chr17

61909339

-
5CDS-3UTRENST00000581882ENST00000581882PSMC5chr17

61909140

+PSMC5chr17

61909339

-
In-frameENST00000310144ENST00000310144PSMC5chr17

61908502

+PSMC5chr17

61908776

-
5CDS-intronENST00000310144ENST00000582420PSMC5chr17

61908502

+PSMC5chr17

61908776

-
5CDS-intronENST00000310144ENST00000580864PSMC5chr17

61908502

+PSMC5chr17

61908776

-
5CDS-intronENST00000310144ENST00000375812PSMC5chr17

61908502

+PSMC5chr17

61908776

-
5CDS-intronENST00000310144ENST00000581882PSMC5chr17

61908502

+PSMC5chr17

61908776

-
intron-3CDSENST00000582420ENST00000310144PSMC5chr17

61908502

+PSMC5chr17

61908776

-
intron-intronENST00000582420ENST00000582420PSMC5chr17

61908502

+PSMC5chr17

61908776

-
intron-intronENST00000582420ENST00000580864PSMC5chr17

61908502

+PSMC5chr17

61908776

-
intron-intronENST00000582420ENST00000375812PSMC5chr17

61908502

+PSMC5chr17

61908776

-
intron-intronENST00000582420ENST00000581882PSMC5chr17

61908502

+PSMC5chr17

61908776

-
In-frameENST00000580864ENST00000310144PSMC5chr17

61908502

+PSMC5chr17

61908776

-
5CDS-intronENST00000580864ENST00000582420PSMC5chr17

61908502

+PSMC5chr17

61908776

-
5CDS-intronENST00000580864ENST00000580864PSMC5chr17

61908502

+PSMC5chr17

61908776

-
5CDS-intronENST00000580864ENST00000375812PSMC5chr17

61908502

+PSMC5chr17

61908776

-
5CDS-intronENST00000580864ENST00000581882PSMC5chr17

61908502

+PSMC5chr17

61908776

-
In-frameENST00000375812ENST00000310144PSMC5chr17

61908502

+PSMC5chr17

61908776

-
5CDS-intronENST00000375812ENST00000582420PSMC5chr17

61908502

+PSMC5chr17

61908776

-
5CDS-intronENST00000375812ENST00000580864PSMC5chr17

61908502

+PSMC5chr17

61908776

-
5CDS-intronENST00000375812ENST00000375812PSMC5chr17

61908502

+PSMC5chr17

61908776

-
5CDS-intronENST00000375812ENST00000581882PSMC5chr17

61908502

+PSMC5chr17

61908776

-
In-frameENST00000581882ENST00000310144PSMC5chr17

61908502

+PSMC5chr17

61908776

-
5CDS-intronENST00000581882ENST00000582420PSMC5chr17

61908502

+PSMC5chr17

61908776

-
5CDS-intronENST00000581882ENST00000580864PSMC5chr17

61908502

+PSMC5chr17

61908776

-
5CDS-intronENST00000581882ENST00000375812PSMC5chr17

61908502

+PSMC5chr17

61908776

-
5CDS-intronENST00000581882ENST00000581882PSMC5chr17

61908502

+PSMC5chr17

61908776

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for PSMC5-PSMC5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PSMC5-PSMC5


check button Go to

FGviewer for the breakpoints of chr17:61908502-chr17:61908776

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePSMC5chr17:61908502chr17:61908776ENST00000310144012190_1970407.0Nucleotide bindingATP
TgenePSMC5chr17:61908502chr17:61908776ENST00000375812012190_1970399.0Nucleotide bindingATP
TgenePSMC5chr17:61908502chr17:61908776ENST00000580864013190_1970399.0Nucleotide bindingATP
TgenePSMC5chr17:61908502chr17:61908776ENST00000581882011190_1970399.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePSMC5chr17:61908502chr17:61908776ENST00000310144+112190_1970407.0Nucleotide bindingATP
HgenePSMC5chr17:61908502chr17:61908776ENST00000375812+112190_1970399.0Nucleotide bindingATP
HgenePSMC5chr17:61908502chr17:61908776ENST00000580864+113190_1970399.0Nucleotide bindingATP
HgenePSMC5chr17:61908502chr17:61908776ENST00000581882+111190_1970399.0Nucleotide bindingATP


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Fusion Gene Sequence for PSMC5-PSMC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PSMC5-PSMC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PSMC5-PSMC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PSMC5-PSMC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePSMC5C0014518Toxic Epidermal Necrolysis1CTD_human
HgenePSMC5C0019693HIV Infections1CTD_human
HgenePSMC5C0038325Stevens-Johnson Syndrome1CTD_human
HgenePSMC5C1274933Drug-Induced Stevens Johnson Syndrome1CTD_human
HgenePSMC5C3658301Mycoplasma-Induced Stevens-Johnson Syndrome1CTD_human
HgenePSMC5C3658302Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum1CTD_human
HgenePSMC5C4505456HIV Coinfection1CTD_human
TgenePSMC5C0014518Toxic Epidermal Necrolysis1CTD_human
TgenePSMC5C0019693HIV Infections1CTD_human
TgenePSMC5C0038325Stevens-Johnson Syndrome1CTD_human
TgenePSMC5C1274933Drug-Induced Stevens Johnson Syndrome1CTD_human
TgenePSMC5C3658301Mycoplasma-Induced Stevens-Johnson Syndrome1CTD_human
TgenePSMC5C3658302Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum1CTD_human
TgenePSMC5C4505456HIV Coinfection1CTD_human