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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PSMD12-PRKCA (FusionGDB2 ID:69231)

Fusion Gene Summary for PSMD12-PRKCA

check button Fusion gene summary
Fusion gene informationFusion gene name: PSMD12-PRKCA
Fusion gene ID: 69231
HgeneTgene
Gene symbol

PSMD12

PRKCA

Gene ID

5718

5578

Gene nameproteasome 26S subunit, non-ATPase 12protein kinase C alpha
SynonymsRpn5|STISS|p55AAG6|PKC-alpha|PKCA|PKCI+/-|PKCalpha|PRKACA
Cytomap

17q24.2

17q24.2

Type of geneprotein-codingprotein-coding
Description26S proteasome non-ATPase regulatory subunit 1226S proteasome regulatory subunit RPN526S proteasome regulatory subunit p55proteasome (prosome, macropain) 26S subunit, non-ATPase, 12protein kinase C alpha typePKC-Aaging-associated gene 6
Modification date2020031320200327
UniProtAcc.

PICK1

Ensembl transtripts involved in fusion geneENST00000356126, ENST00000357146, 
ENST00000581618, 		ENST00000413366, 
ENST00000583361, 
Fusion gene scores* DoF score6 X 6 X 3=10826 X 21 X 9=4914
# samples 929
** MAII scorelog2(9/108*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(29/4914*10)=-4.08277305234723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PSMD12 [Title/Abstract] AND PRKCA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPSMD12(65340722)-PRKCA(64492319), # samples:2
Anticipated loss of major functional domain due to fusion event.PSMD12-PRKCA seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PSMD12-PRKCA seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PSMD12-PRKCA seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
PSMD12-PRKCA seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PSMD12-PRKCA seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
PSMD12-PRKCA seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PSMD12-PRKCA seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePRKCA

GO:0006468

protein phosphorylation

10770950

TgenePRKCA

GO:0035408

histone H3-T6 phosphorylation

20228790

TgenePRKCA

GO:0043536

positive regulation of blood vessel endothelial cell migration

20011604

TgenePRKCA

GO:0090330

regulation of platelet aggregation

12724315


check buttonFusion gene breakpoints across PSMD12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PRKCA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A12P-01APSMD12chr17

65340722

-PRKCAchr17

64492319

+
ChimerDB4BRCATCGA-C8-A12PPSMD12chr17

65340721

-PRKCAchr17

64492318

+
ChimerDB4BRCATCGA-C8-A12P-01APSMD12chr17

65340722

-PRKCAchr17

64492319

+
ChimerDB4BRCATCGA-C8-A12P-01APSMD12chr17

65340722

-PRKCAchr17

64637473

+
ChimerDB4BRCATCGA-C8-A12P-01APSMD12chr17

65341861

-PRKCAchr17

64492319

+


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Fusion Gene ORF analysis for PSMD12-PRKCA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000356126ENST00000413366PSMD12chr17

65340722

-PRKCAchr17

64492319

+
5CDS-intronENST00000356126ENST00000583361PSMD12chr17

65340722

-PRKCAchr17

64492319

+
Frame-shiftENST00000357146ENST00000413366PSMD12chr17

65340722

-PRKCAchr17

64492319

+
5CDS-intronENST00000357146ENST00000583361PSMD12chr17

65340722

-PRKCAchr17

64492319

+
intron-3CDSENST00000581618ENST00000413366PSMD12chr17

65340722

-PRKCAchr17

64492319

+
intron-intronENST00000581618ENST00000583361PSMD12chr17

65340722

-PRKCAchr17

64492319

+
Frame-shiftENST00000356126ENST00000413366PSMD12chr17

65340721

-PRKCAchr17

64492318

+
5CDS-intronENST00000356126ENST00000583361PSMD12chr17

65340721

-PRKCAchr17

64492318

+
Frame-shiftENST00000357146ENST00000413366PSMD12chr17

65340721

-PRKCAchr17

64492318

+
5CDS-intronENST00000357146ENST00000583361PSMD12chr17

65340721

-PRKCAchr17

64492318

+
intron-3CDSENST00000581618ENST00000413366PSMD12chr17

65340721

-PRKCAchr17

64492318

+
intron-intronENST00000581618ENST00000583361PSMD12chr17

65340721

-PRKCAchr17

64492318

+
In-frameENST00000356126ENST00000413366PSMD12chr17

65340722

-PRKCAchr17

64637473

+
5CDS-intronENST00000356126ENST00000583361PSMD12chr17

65340722

-PRKCAchr17

64637473

+
In-frameENST00000357146ENST00000413366PSMD12chr17

65340722

-PRKCAchr17

64637473

+
5CDS-intronENST00000357146ENST00000583361PSMD12chr17

65340722

-PRKCAchr17

64637473

+
intron-3CDSENST00000581618ENST00000413366PSMD12chr17

65340722

-PRKCAchr17

64637473

+
intron-intronENST00000581618ENST00000583361PSMD12chr17

65340722

-PRKCAchr17

64637473

+
Frame-shiftENST00000356126ENST00000413366PSMD12chr17

65341861

-PRKCAchr17

64492319

+
5CDS-intronENST00000356126ENST00000583361PSMD12chr17

65341861

-PRKCAchr17

64492319

+
Frame-shiftENST00000357146ENST00000413366PSMD12chr17

65341861

-PRKCAchr17

64492319

+
5CDS-intronENST00000357146ENST00000583361PSMD12chr17

65341861

-PRKCAchr17

64492319

+
intron-3CDSENST00000581618ENST00000413366PSMD12chr17

65341861

-PRKCAchr17

64492319

+
intron-intronENST00000581618ENST00000583361PSMD12chr17

65341861

-PRKCAchr17

64492319

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356126PSMD12chr1765340722-ENST00000413366PRKCAchr1764637473+96281191182921967
ENST00000357146PSMD12chr1765340722-ENST00000413366PRKCAchr1764637473+95461109862839917

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356126ENST00000413366PSMD12chr1765340722-PRKCAchr1764637473+0.0002485360.9997515
ENST00000357146ENST00000413366PSMD12chr1765340722-PRKCAchr1764637473+0.0003167940.99968326

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Fusion Genomic Features for PSMD12-PRKCA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PSMD12chr1765341860-PRKCAchr1764492318+5.41E-050.9999459
PSMD12chr1765340721-PRKCAchr1764492318+9.85E-080.9999999
PSMD12chr1765340721-PRKCAchr1764492318+9.85E-080.9999999
PSMD12chr1765340721-PRKCAchr1764637472+4.26E-081
PSMD12chr1765341860-PRKCAchr1764492318+5.41E-050.9999459
PSMD12chr1765340721-PRKCAchr1764492318+9.85E-080.9999999
PSMD12chr1765340721-PRKCAchr1764492318+9.85E-080.9999999
PSMD12chr1765340721-PRKCAchr1764637472+4.26E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PSMD12-PRKCA


check button Go to

FGviewer for the breakpoints of chr17:65340722-chr17:64637473

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.PRKCA

PICK1

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.415

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePRKCAchr17:65340722chr17:64637473ENST00000413366217158_27596.0673.0DomainC2
TgenePRKCAchr17:65340722chr17:64637473ENST00000413366217339_59796.0673.0DomainProtein kinase
TgenePRKCAchr17:65340722chr17:64637473ENST00000413366217598_66896.0673.0DomainAGC-kinase C-terminal
TgenePRKCAchr17:65340722chr17:64637473ENST00000413366217345_35396.0673.0Nucleotide bindingATP
TgenePRKCAchr17:65340722chr17:64637473ENST00000413366217101_15196.0673.0Zinc fingerPhorbol-ester/DAG-type 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePSMD12chr17:65340722chr17:64637473ENST00000356126-911242_420361.0457.0DomainPCI
HgenePSMD12chr17:65340722chr17:64637473ENST00000357146-810242_420341.0437.0DomainPCI
TgenePRKCAchr17:65340722chr17:64637473ENST0000041336621736_8696.0673.0Zinc fingerPhorbol-ester/DAG-type 1


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Fusion Gene Sequence for PSMD12-PRKCA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000356126_ENST00000413366_TCGA-C8-A12P-01A_PSMD12_chr17_65340722_-_PRKCA_chr17_64637473_length(transcript)=9628nt_BP=1191nt
GCGTGGGCTCCCGATGGGCTGCCTGAGCGGGTGCGCGGGCAACTTCCGGTGTGGGTGACGAGTGGTGGCCGAAGCAGGGGGACAGCAAGG
GACGCTCAGGCGGGGACCATGGCGGACGGCGGCTCGGAGCGGGCTGACGGGCGCATCGTCAAGATGGAGGTGGACTACAGCGCCACGGTG
GATCAGCGCCTACCCGAGTGTGCGAAGCTAGCCAAGGAAGGAAGACTTCAAGAAGTCATTGAAACCCTTCTCTCTCTGGAAAAGCAGACT
CGTACTGCTTCCGATATGGTATCGACATCCCGTATCTTAGTTGCAGTAGTGAAGATGTGCTATGAGGCTAAAGAATGGGATTTACTTAAT
GAAAATATTATGCTTTTGTCCAAAAGGCGGAGTCAGTTAAAACAAGCTGTTGCCAAAATGGTTCAACAGTGCTGTACTTATGTTGAGGAA
ATCACAGACCTTCCTATCAAACTTCGATTAATTGATACTCTACGAATGGTTACCGAAGGCAAGATTTATGTTGAAATTGAGCGTGCGCGA
CTGACTAAAACATTAGCAACTATAAAAGAACAAAATGGTGATGTGAAAGAGGCAGCCTCCATTTTACAGGAGTTACAGGTGGAAACCTAC
GGGTCAATGGAAAAGAAAGAGCGAGTGGAATTTATTTTGGAGCAAATGAGGCTCTGCCTAGCTGTGAAGGATTACATTCGAACACAAATC
ATCAGCAAGAAAATTAACACCAAATTTTTCCAGGAAGAAAATACAGAGAAATTAAAGTTGAAGTACTATAATTTAATGATTCAGCTGGAT
CAACATGAGGGATCCTATTTGTCTATTTGTAAGCACTACAGAGCAATATATGATACTCCCTGTATACAGGCAGAAAGTGAAAAATGGCAG
CAGGCTCTGAAGAGTGTTGTACTCTATGTTATCCTGGCTCCTTTTGACAATGAACAGTCAGATTTGGTTCACCGAATAAGTGGTGACAAG
AAGTTAGAAGAAATTCCCAAATACAAGGATCTTTTAAAGCTTTTTACCACAATGGAGTTGATGCGTTGGTCCACACTTGTTGAGGACTAT
GGAATGGAATTAAGAAAAGGTTCCCTTGAGAGTCCTGCAACGGATGTTTTTGGTTCTACAGAGGAAGGTGAAAAAAGGTGGAAAGACTTG
AAGAACAGAGTTGTTGAACATGACCCCAGGAGCAAGCACAAGTTCAAAATCCACACTTACGGAAGCCCCACCTTCTGCGATCACTGTGGG
TCACTGCTCTATGGACTTATCCATCAAGGGATGAAATGTGACACCTGCGATATGAACGTTCACAAGCAATGCGTCATCAATGTCCCCAGC
CTCTGCGGAATGGATCACACTGAGAAGAGGGGGCGGATTTACCTAAAGGCTGAGGTTGCTGATGAAAAGCTCCATGTCACAGTACGAGAT
GCAAAAAATCTAATCCCTATGGATCCAAACGGGCTTTCAGATCCTTATGTGAAGCTGAAACTTATTCCTGATCCCAAGAATGAAAGCAAG
CAAAAAACCAAAACCATCCGCTCCACACTAAATCCGCAGTGGAATGAGTCCTTTACATTCAAATTGAAACCTTCAGACAAAGACCGACGA
CTGTCTGTAGAAATCTGGGACTGGGATCGAACAACAAGGAATGACTTCATGGGATCCCTTTCCTTTGGAGTTTCGGAGCTGATGAAGATG
CCGGCCAGTGGATGGTACAAGTTGCTTAACCAAGAAGAAGGTGAGTACTACAACGTACCCATTCCGGAAGGGGACGAGGAAGGAAACATG
GAACTCAGGCAGAAATTCGAGAAAGCCAAACTTGGCCCTGCTGGCAACAAAGTCATCAGTCCCTCTGAAGACAGGAAACAACCTTCCAAC
AACCTTGACCGAGTGAAACTCACGGACTTCAATTTCCTCATGGTGTTGGGAAAGGGGAGTTTTGGAAAGGTGATGCTTGCCGACAGGAAG
GGCACAGAAGAACTGTATGCAATCAAAATCCTGAAGAAGGATGTGGTGATTCAGGATGATGACGTGGAGTGCACCATGGTAGAAAAGCGA
GTCTTGGCCCTGCTTGACAAACCCCCGTTCTTGACGCAGCTGCACTCCTGCTTCCAGACAGTGGATCGGCTGTACTTCGTCATGGAATAT
GTCAACGGTGGGGACCTCATGTACCACATTCAGCAAGTAGGAAAATTTAAGGAACCACAAGCAGTATTCTATGCGGCAGAGATTTCCATC
GGATTGTTCTTTCTTCATAAAAGAGGAATCATTTATAGGGATCTGAAGTTAGATAACGTCATGTTGGATTCAGAAGGACATATCAAAATT
GCTGACTTTGGGATGTGCAAGGAACACATGATGGATGGAGTCACGACCAGGACCTTCTGTGGGACTCCAGATTATATCGCCCCAGAGATA
ATCGCTTATCAGCCGTATGGAAAATCTGTGGACTGGTGGGCCTATGGCGTCCTGTTGTATGAAATGCTTGCCGGGCAGCCTCCATTTGAT
GGTGAAGATGAAGACGAGCTATTTCAGTCTATCATGGAGCACAACGTTTCCTATCCAAAATCCTTGTCCAAGGAGGCTGTTTCTGTCTGC
AAAGGACTGATGACCAAACACCCAGCCAAGCGGCTGGGCTGTGGGCCTGAGGGGGAGAGGGACGTGAGAGAGCATGCCTTCTTCCGGAGG
ATCGACTGGGAAAAACTGGAGAACAGGGAGATCCAGCCACCATTCAAGCCCAAAGTGTGTGGCAAAGGAGCAGAGAACTTTGACAAGTTC
TTCACACGAGGACAGCCCGTCTTAACACCACCTGATCAGCTGGTTATTGCTAACATAGACCAGTCTGATTTTGAAGGGTTCTCGTATGTC
AACCCCCAGTTTGTGCACCCCATCTTACAGAGTGCAGTATGAAACTCACCAGCGAGAACAAACACCTCCCCAGCCCCCAGCCCTCCCCGC
AGTGGGAAGTGAATCCTTAACCCTAAAATTTTAAGGCCACGGCCTTGTGTCTGATTCCATATGGAGGCCTGAAAATTGTAGGGTTATTAG
TCCAAATGTGATCAACTGTTCAGGGTCTCTCTCTTACAACCAAGAACATTATCTTAGTGGAAGATGGTACGTCATGCTCAGTGTCCAGTT
TAATTCTGTAGAAGTTACGTCTGGCTCTAGGTTAACCCTTCCTAGAAAGCAAGCAGACTGTTGCCCCATTTTGGGTACAATTTGATATAC
TTTCCATACCCTCCATCTGTGGATTTTTCAGCATTGGAATCCCCCAACCAGAGATGTTAAAGTGAGCCTGTCCCAGGAAACATCTCCACC
CAAGACGTCTTTGGAATCCAAGAACAGGAAGCCAAGAGAGTGAGCAGGGAGGGATTGGGGGTGGGGGAGGCCTCAAAATACCGACTGCGT
CCATTCTCTGCCTCCATGGAAACAGCCCCTAGAATCTGAAAGGCCGGGATAAACCTAATCACTGTTCCCAAACATTGACAAATCCTAACC
CAACCATGGTCCAGCAGTTACCAGTTTAAACAAAAAAACCTCAGATGAGTGTTGGGTGAATCTGTCATCTGGTACCCTCCTTGGTTGATA
ACTGTCTTGATACTTTTCATTCTTTGTAAGAGGCCAAATCGTCTAAGGACGTTGCTGAACAAGCGTGTGAAATCATTTCAGATCAAGGAT
AAGCCAGTGTGTACATATGTTCATTTTAATCTCTGGGAGATTATTTTTCCATCCAGGGTGCCATCAGTAATCATGCCACTACTCACCAGT
GTTGTTCACCAACACCCACCCCCACACACACCAACATTTTGCTGCCTACCTTGTTATCCTTCTCAAGAAGCTGAAGTGTACGCCCTCTCC
CCTTTTGTGCTTATTTATTTAATAGGCTGCAGTGTCGCTTATGAAAGTACGATGTACAGTAACTTAATGGAAGTGCTGACTCTAGCATCA
GCCTCTACCGATTGATTTTCCTCCCTTCTCTAGCCCTGGATGTCCACTTAGGGATAAAAAGAATATGGTTTTGGTTCCCATTTCTAGTTC
ACGTTGAATGACAGGCCTGGAGCTGTAGAATCAGGAAACCCGGATGCCTAACAGCTCAAAGATGTTTTGTTAATAGAAGGATTTTAATAC
GTTTTGCAAATGCATCATGCAATGAATTTTGCATGTTTATAATAAACCTTAATAACAAGTGAATCTATATTATTGATATAATCGTATCAA
GTATAAAGAGAGTATTATAATAATTTTATAAGACACAATTGTGCTCTATTTGTGCAGGTTCTTGTTTCTAATCCTCTTTTCTAATTAAGT
TTTAGCTGAATCCCTTGCTTCTGTGCTTTCCCTCCCTGCACATGGGCACTGTATCAGATAGATTACTTTTTAAATGTAGATAAAATTTCA
AAAATGAATGGCTAGTTTACGTGATAGATTAGGCTCTTACTACATATGTGTGTGTATATATATGTATTTGATTCTACCTGCAAACAAATT
TTTATTGGTGAGGACTATTTTTGAGCTGACACTCCCTCTTAGTTTCTTCATGTCACCTTTCGTCCTGGTTCCTCCGCCACTCTTCCTCTT
GGGGACAACAGGAAGTGTCTGATTCCAGTCTGCCTAGTACGTTGGTACACACGTGGCATTGCCGCAGCACCTGGGCTGACCTTTGTGTGT
GCGTGTGTGTGTGTTTCCTTCTTCCCTTCAGCCTGTGACTGTTGCTGACTCCAGGGGTGGGAGGGATGGGGAGACTCCCCTCTTGCTGTG
TGTACTGGACACGCAGGAAGCATGCTGTCTTGCTGCCTCTGCAACGACCTGTCGTTTGCTCCAGCATGCACAAACTTCGTGAGACCAACA
CAGCCGTGCCCTGCAGGCACCAGCACGTGCTTTTCAGAGGCTGCGGACTTTCTTCCAGCCATTGTGGCATTGGCCTTTCCAGTCTTGGGA
GGAGCGCGCTGCTTTGGTGAGACACCCCCATGCAAGGTCCTCAGAGTAGCCGGGTTCTACCACAAACAGAAACAGAATGAAAGTAGCTGT
CAGTCCTTGTAGAGAGCCGCTCTGTTTCCTCCCAGAAGCATCTCCCAGCTAAGCTCGCATTATTTTTCTCCTCTGGCTGTTTGCCTGAAG
TTCACAGAACACACAACCATGAAAGGCTTTTTGAGGTGAGAGGCCCAGGTGGTCCTGGCAACCCTGAGTAGAAGGAGAGACGGGGTAGGG
AACGGGCCCGGCCAGAAAAGAACCATTTCTTCTGCCATCTTTTATGCACCATAGACATCGAGACTCCAGGGGGTCCTGGCTCCCCTGTCC
CTGCAGCCCTGCAGGTCAGTGCATGATCTGGGTTCGTGTCCTGACCAGGTGCTCCTCCTTTGATCCGAGGGGAAAGGGACTGGTTTATAG
AAAGAGCCTAGGAGACAAAAGGGCCAGTCCCCCTGCCCAGAATGGAGCAGCAGCAGGACAGACCCCCACGAGGCCCCCCAGAGAGGAGGA
AGATCCCACGGAGGAACACATGAGGTTAGGGACCCTTGTTCAGCACCCCAAACAGCCTGCCTGTTTAAAGCAGGCAGCAGGCTTAGGCCT
TCCCTGCAACCCCAACACCCACAAGTTTGTTTCTCTAGGAAACACATTCACTGTCTCAGCTGGCTGTTACTCTCTCAGACCATATGGCAA
AGTTTTCCAAGAAAATGCCCCGACAGGGGTGCCCAGCACACTGCCTGAGGGACAACAGACATCAGAACAAACCCCCAGAGAGAAACAGTC
AAAATCAGGGCCCGGTGCAGTGTTGTCATGTGGAACCTGCTTTATCCATTGCTGAGTGTTGAATGTGGGTAATGGTTAGGGCTTTCCAGA
TCTCAGCAGCCAAAGACAGTTATTGTTGGAAGACTGTCATGTAGATAACCATGAGCAATGGCTCGCCTCAGAATCAGTTCATAAAATTCT
ATGGTACTGGCCCCTTCGTGGGTATTGTGTGAAATGAGATGGTGGCGAGGGGTGCGCTGTGGAACTGCCGCAGCCACGCAGGAGGTCCCT
GGGGGATGCTTTGGGAAGTCCTTGCCCCTGAGCACTGCCTGATTGCCAGGGCCTGTGGAGGTCTAGGCCGCCTGGCAGAATCTAGCACCG
TCCGAATCCCCGCAGGACCCATGGAGCTATGACCACACCAGGCCATTCAAATGGCTCTGCATTATCTTCCCTTGGAAGGTGGCCACTCCT
CGGTGGCAGGGCCTTTCCCTGAGGCTGCAGGCCGTGGGCTGGCAGCCCGTCTCTTGGCATTTCAATTGAAGGTCACCAGGTGCTGGGTTT
GAAAGGAAGTCACTGGAGTGCTGCCAGGGGCCGCCCTCCAAGGTTAATGAGAGGCCCACATCCAGGCAAGAACTAATTCAAAAGGCAGAT
CAGAAACCACAGGAGTCAAAATTATTGCTCCGGCAGTGCTTCCCTTCCTTTCATCCACTGGCCTCGTGTGGTCCATGCAGGGCCACTGTC
TGCCCTTTCTGATGCCACGTATTAGGCTTTCTTACTCAGAATTTTGATAGAAAACCATGGGGCCAAGAGCTCTGGAAGCCTGGCCGGAAA
GACCAAGGTTCATGCAGCCCAACAAATGATTGTTGAGCACCTCTCGGAGCCAAAGTCCTTAGGCGAGTGTGGTGACTTCCTGGAAGGAGG
ATGCAGACTTCCAGAGAGCCCCCCCAACGGACGTGCTGAGAAGGGAGAGGGAGGCGGGGGCTGTAGTCAGGAAGGAGCCAGAGAAGAACA
GGGTTTGGGTGCATCCAGAAATATGCCTGCAGTAGGAGGGAGAGGAAGGGGTGCCACCGTCAACGGCTTCCCATCGGAGGTGGTTGGTGC
AGATGGAAGTTTCTGTCTGCTGGCCCTCAAGAGAGTGTTTTGCCAGGGACACAGTCTGTTCCTCCTCAGAAAACACCCCCCAAATGCTAA
CAACATCCCCACCAGCTGCTAGAAGCCCCTTTCCCCTCCCCACCTTGAAGTAGCTCATAGTTCTCTGGGCAGAGCCAGACCATCCAGTGT
ACCCCAGAGGCCAGTAGGTTCCTGCCCATTTTCCTCTCTGGCTTCCTGCCAAGAATTATGGCAGCTGAGGATGAATGGAGAAGTAAAAAC
AACTAACACCGCACAACTAACAACTAACACCGCAGTTCCCACCTGGGTTCCACTTAGCAGGAGACATTTCGGAGGGTTTTTTTTGTTTTT
GTTCCTGTTTTTTTTTTTTTTGCTGGAATTTGTTTTCTCAGTACTGAAAAGAGAAAAAGTGACAATCTTGTATTTTTAAAAGCCTCGGAA
AGGTGATACCATCTGACAGTCATTTTCTCACGTTGGTCTTCTAAAGTCACCTATTTCTTGTGTGTGCACATCACACCATTTCCTGTTTCT
TTATAACCCGACAAGGGTAGGAGTGCCTGTTTCCCCTGCTGGGCACACCAGACAATCGTAATCACAAAACAGACACTGAGCCAGGGGCCC
AAAGGGTGTGATCATGAGAGTTACCGGGACAGCAGTAGGCATGACAGTCACCAGGAAGGACAAGGGTGCTCTGTTGTTAGTGGCCACACA
CCAATTTGACAAGGAGTGTTGCGAAATTTTTATTTATTTATTTATTTATTTTGAGATGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGC
GGTGGTACAATCTCGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTACCTGGGACTACAGGT
GCGTGCCACCACACCCAGCTAAATTTTGTGTTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGATGGTCTTGAACCCCTGACCTCA
TGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCCAAAATATTTTTTTAAAGTCATTTTCCT
TAAGCTGCTTGGGCTACATGTGAAATACACTGGACGGTCAACATTCCTGTCTCCTCCCATTTGGGCTGATGCAGCAGATCCAGGGAATGT
TACCTGTTTCTGCTGCTAGAAGATCCAGGAAATTGGGAAGGTTACCTGACGCACACATGGATGAAGGCCATCATCTAGAAATGGGGTCAA
CCACAATTGTGTTAATTCCGTAGTGTCAGGGATTCTTCGGGAAGGTCAACAGTATGAAGGATTCTGACCCCTGTGCCTCCCATTTATGTG
ATCAGGTGACAGTTAATAACCGTGGAGGTCACACTCAGCCATCCAACAGCCTTACAGTGACCCTACACAAAAGCCCCCAAATTCCAAAGA
CTTTTTCTTAACCTAAAGGAAGAAATTATTTGTTAATTCCAGTAGAGCAACTGAATATACTGGGCTATTTGTACTTTTTTATAGAGAACT
TTAATAATAATTCTTTAAAAATGAGTTTTTAGAACAAAGCAACTGACGATTTCCTAAGATTCCAATGCCCTGGAGCTTGTAGGAGGACTT
AGCCTGGGTCAGCTGGAGCACCCCCGACCTGATCTCCCACTGCCAGATTTTCCCATGCTCCTAGGGTATGGAGTCCACGTGGGAATGACT
GCAAGTTCAGGTGGAACTTGGCCGACTGATGCTCTGCGAGTTTTTAATAGACACTGGGGACAACTGCTTAAGGTTTAGAAACTTCCAAAC
CACAGGAAAGACATTTTTAGTGTCCCCCATCCAGAGGCAGCCCTGGAATAGGATTCCCAGGGGTTTCTGGGACCCCTTTCCTTGCTCCGT
GAGGCTCTGTGGCCATCTTTTGGCAGGAGGAGGATGCTTCCTTGGCTCTGTGCCCAGACCCGCCTGGTCCCCAGGTCTCTCACCTTGGGT
GAAGATTCAGAGATGCCCTGTAAGGATTTTGCCCACTGGGCAACTCAGAAATACTTCGATCTCCCAAGATATAAGAGGCAGCAGCAAACG
TGCCTATTGACGTCTGTTTCATAGTTACCACTTACGCGAGTAGACAGAACTCGGCTTTTCAGAAAATAGGTGTCAAGTCCACTTTATAAG
AACCTTTTTTTCTAAAATAAGATAAAAGGTGGCTTTGCATTTTCTGATTAAACGACTGTGTCTTTGTCACCTCTGCTTAACTTTAGGAGT
ATCCATTCCTGTGATTGTAGACTTTTGTTGATATTCTTCCTGGAAGAATATCATTCTTTTCTTGAAGGGTTGGTTTACTAGAATATTCAA
AATCAATCATGAAGGCAGTTACTATTTTGAGTCTAAAGGTTTTCTAAAAATTAACCTCACATCCCTTCTGTTAGGGTCTTTCAGAATATC
TTTTATAAACAGAAGCATTTGAAGTCATTGCTTTTGCTACATGATTTGTGTGTGTGAAGGACATACCACGTTTAAATCATTAATTGAAAA
ACATCATATAAGCCCCAACTTTGTTTGGAGGAAGAGACGGAGGTTGAGGTTTTTCCTTCTGTATAAGCACCTACTGACAAAATGTAGAGG
CCATTCAACCGTCAAACACCATTTGGTTATATCGCAGAGGAGACGGATGTGTAAATTACTGCATTGCTTTTTTTTTCAGTTTGTATAACC

>In-frame_ENST00000356126_ENST00000413366_TCGA-C8-A12P-01A_PSMD12_chr17_65340722_-_PRKCA_chr17_64637473_length(amino acids)=967AA_start in transcript=18_stop in transcript=2921
MPERVRGQLPVWVTSGGRSRGTARDAQAGTMADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDM
VSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLA
TIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSY
LSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRK
GSLESPATDVFGSTEEGEKRWKDLKNRVVEHDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDH
TEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIW
DWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVK
LTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDL
MYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPY
GKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKL

--------------------------------------------------------------
>In-frame_ENST00000357146_ENST00000413366_TCGA-C8-A12P-01A_PSMD12_chr17_65340722_-_PRKCA_chr17_64637473_length(transcript)=9546nt_BP=1109nt
CTGAGCGGGTGCGCGGGCAACTTCCGGTGTGGGTGACGAGTGGTGGCCGAAGCAGGGGGACAGCAAGGGACGCTCAGGCGGGGACCATGG
CGGACGGCGGCTCGGAGCGGGCTGACGGGCGCATCGTCAAGATGGAGGTGGACTACAGCGCCACGGTGGATCAGCGCCTACCCGAGTGTG
CGAAGCTAGCCAAGGCTTCCGATATGGTATCGACATCCCGTATCTTAGTTGCAGTAGTGAAGATGTGCTATGAGGCTAAAGAATGGGATT
TACTTAATGAAAATATTATGCTTTTGTCCAAAAGGCGGAGTCAGTTAAAACAAGCTGTTGCCAAAATGGTTCAACAGTGCTGTACTTATG
TTGAGGAAATCACAGACCTTCCTATCAAACTTCGATTAATTGATACTCTACGAATGGTTACCGAAGGCAAGATTTATGTTGAAATTGAGC
GTGCGCGACTGACTAAAACATTAGCAACTATAAAAGAACAAAATGGTGATGTGAAAGAGGCAGCCTCCATTTTACAGGAGTTACAGGTGG
AAACCTACGGGTCAATGGAAAAGAAAGAGCGAGTGGAATTTATTTTGGAGCAAATGAGGCTCTGCCTAGCTGTGAAGGATTACATTCGAA
CACAAATCATCAGCAAGAAAATTAACACCAAATTTTTCCAGGAAGAAAATACAGAGAAATTAAAGTTGAAGTACTATAATTTAATGATTC
AGCTGGATCAACATGAGGGATCCTATTTGTCTATTTGTAAGCACTACAGAGCAATATATGATACTCCCTGTATACAGGCAGAAAGTGAAA
AATGGCAGCAGGCTCTGAAGAGTGTTGTACTCTATGTTATCCTGGCTCCTTTTGACAATGAACAGTCAGATTTGGTTCACCGAATAAGTG
GTGACAAGAAGTTAGAAGAAATTCCCAAATACAAGGATCTTTTAAAGCTTTTTACCACAATGGAGTTGATGCGTTGGTCCACACTTGTTG
AGGACTATGGAATGGAATTAAGAAAAGGTTCCCTTGAGAGTCCTGCAACGGATGTTTTTGGTTCTACAGAGGAAGGTGAAAAAAGGTGGA
AAGACTTGAAGAACAGAGTTGTTGAACATGACCCCAGGAGCAAGCACAAGTTCAAAATCCACACTTACGGAAGCCCCACCTTCTGCGATC
ACTGTGGGTCACTGCTCTATGGACTTATCCATCAAGGGATGAAATGTGACACCTGCGATATGAACGTTCACAAGCAATGCGTCATCAATG
TCCCCAGCCTCTGCGGAATGGATCACACTGAGAAGAGGGGGCGGATTTACCTAAAGGCTGAGGTTGCTGATGAAAAGCTCCATGTCACAG
TACGAGATGCAAAAAATCTAATCCCTATGGATCCAAACGGGCTTTCAGATCCTTATGTGAAGCTGAAACTTATTCCTGATCCCAAGAATG
AAAGCAAGCAAAAAACCAAAACCATCCGCTCCACACTAAATCCGCAGTGGAATGAGTCCTTTACATTCAAATTGAAACCTTCAGACAAAG
ACCGACGACTGTCTGTAGAAATCTGGGACTGGGATCGAACAACAAGGAATGACTTCATGGGATCCCTTTCCTTTGGAGTTTCGGAGCTGA
TGAAGATGCCGGCCAGTGGATGGTACAAGTTGCTTAACCAAGAAGAAGGTGAGTACTACAACGTACCCATTCCGGAAGGGGACGAGGAAG
GAAACATGGAACTCAGGCAGAAATTCGAGAAAGCCAAACTTGGCCCTGCTGGCAACAAAGTCATCAGTCCCTCTGAAGACAGGAAACAAC
CTTCCAACAACCTTGACCGAGTGAAACTCACGGACTTCAATTTCCTCATGGTGTTGGGAAAGGGGAGTTTTGGAAAGGTGATGCTTGCCG
ACAGGAAGGGCACAGAAGAACTGTATGCAATCAAAATCCTGAAGAAGGATGTGGTGATTCAGGATGATGACGTGGAGTGCACCATGGTAG
AAAAGCGAGTCTTGGCCCTGCTTGACAAACCCCCGTTCTTGACGCAGCTGCACTCCTGCTTCCAGACAGTGGATCGGCTGTACTTCGTCA
TGGAATATGTCAACGGTGGGGACCTCATGTACCACATTCAGCAAGTAGGAAAATTTAAGGAACCACAAGCAGTATTCTATGCGGCAGAGA
TTTCCATCGGATTGTTCTTTCTTCATAAAAGAGGAATCATTTATAGGGATCTGAAGTTAGATAACGTCATGTTGGATTCAGAAGGACATA
TCAAAATTGCTGACTTTGGGATGTGCAAGGAACACATGATGGATGGAGTCACGACCAGGACCTTCTGTGGGACTCCAGATTATATCGCCC
CAGAGATAATCGCTTATCAGCCGTATGGAAAATCTGTGGACTGGTGGGCCTATGGCGTCCTGTTGTATGAAATGCTTGCCGGGCAGCCTC
CATTTGATGGTGAAGATGAAGACGAGCTATTTCAGTCTATCATGGAGCACAACGTTTCCTATCCAAAATCCTTGTCCAAGGAGGCTGTTT
CTGTCTGCAAAGGACTGATGACCAAACACCCAGCCAAGCGGCTGGGCTGTGGGCCTGAGGGGGAGAGGGACGTGAGAGAGCATGCCTTCT
TCCGGAGGATCGACTGGGAAAAACTGGAGAACAGGGAGATCCAGCCACCATTCAAGCCCAAAGTGTGTGGCAAAGGAGCAGAGAACTTTG
ACAAGTTCTTCACACGAGGACAGCCCGTCTTAACACCACCTGATCAGCTGGTTATTGCTAACATAGACCAGTCTGATTTTGAAGGGTTCT
CGTATGTCAACCCCCAGTTTGTGCACCCCATCTTACAGAGTGCAGTATGAAACTCACCAGCGAGAACAAACACCTCCCCAGCCCCCAGCC
CTCCCCGCAGTGGGAAGTGAATCCTTAACCCTAAAATTTTAAGGCCACGGCCTTGTGTCTGATTCCATATGGAGGCCTGAAAATTGTAGG
GTTATTAGTCCAAATGTGATCAACTGTTCAGGGTCTCTCTCTTACAACCAAGAACATTATCTTAGTGGAAGATGGTACGTCATGCTCAGT
GTCCAGTTTAATTCTGTAGAAGTTACGTCTGGCTCTAGGTTAACCCTTCCTAGAAAGCAAGCAGACTGTTGCCCCATTTTGGGTACAATT
TGATATACTTTCCATACCCTCCATCTGTGGATTTTTCAGCATTGGAATCCCCCAACCAGAGATGTTAAAGTGAGCCTGTCCCAGGAAACA
TCTCCACCCAAGACGTCTTTGGAATCCAAGAACAGGAAGCCAAGAGAGTGAGCAGGGAGGGATTGGGGGTGGGGGAGGCCTCAAAATACC
GACTGCGTCCATTCTCTGCCTCCATGGAAACAGCCCCTAGAATCTGAAAGGCCGGGATAAACCTAATCACTGTTCCCAAACATTGACAAA
TCCTAACCCAACCATGGTCCAGCAGTTACCAGTTTAAACAAAAAAACCTCAGATGAGTGTTGGGTGAATCTGTCATCTGGTACCCTCCTT
GGTTGATAACTGTCTTGATACTTTTCATTCTTTGTAAGAGGCCAAATCGTCTAAGGACGTTGCTGAACAAGCGTGTGAAATCATTTCAGA
TCAAGGATAAGCCAGTGTGTACATATGTTCATTTTAATCTCTGGGAGATTATTTTTCCATCCAGGGTGCCATCAGTAATCATGCCACTAC
TCACCAGTGTTGTTCACCAACACCCACCCCCACACACACCAACATTTTGCTGCCTACCTTGTTATCCTTCTCAAGAAGCTGAAGTGTACG
CCCTCTCCCCTTTTGTGCTTATTTATTTAATAGGCTGCAGTGTCGCTTATGAAAGTACGATGTACAGTAACTTAATGGAAGTGCTGACTC
TAGCATCAGCCTCTACCGATTGATTTTCCTCCCTTCTCTAGCCCTGGATGTCCACTTAGGGATAAAAAGAATATGGTTTTGGTTCCCATT
TCTAGTTCACGTTGAATGACAGGCCTGGAGCTGTAGAATCAGGAAACCCGGATGCCTAACAGCTCAAAGATGTTTTGTTAATAGAAGGAT
TTTAATACGTTTTGCAAATGCATCATGCAATGAATTTTGCATGTTTATAATAAACCTTAATAACAAGTGAATCTATATTATTGATATAAT
CGTATCAAGTATAAAGAGAGTATTATAATAATTTTATAAGACACAATTGTGCTCTATTTGTGCAGGTTCTTGTTTCTAATCCTCTTTTCT
AATTAAGTTTTAGCTGAATCCCTTGCTTCTGTGCTTTCCCTCCCTGCACATGGGCACTGTATCAGATAGATTACTTTTTAAATGTAGATA
AAATTTCAAAAATGAATGGCTAGTTTACGTGATAGATTAGGCTCTTACTACATATGTGTGTGTATATATATGTATTTGATTCTACCTGCA
AACAAATTTTTATTGGTGAGGACTATTTTTGAGCTGACACTCCCTCTTAGTTTCTTCATGTCACCTTTCGTCCTGGTTCCTCCGCCACTC
TTCCTCTTGGGGACAACAGGAAGTGTCTGATTCCAGTCTGCCTAGTACGTTGGTACACACGTGGCATTGCCGCAGCACCTGGGCTGACCT
TTGTGTGTGCGTGTGTGTGTGTTTCCTTCTTCCCTTCAGCCTGTGACTGTTGCTGACTCCAGGGGTGGGAGGGATGGGGAGACTCCCCTC
TTGCTGTGTGTACTGGACACGCAGGAAGCATGCTGTCTTGCTGCCTCTGCAACGACCTGTCGTTTGCTCCAGCATGCACAAACTTCGTGA
GACCAACACAGCCGTGCCCTGCAGGCACCAGCACGTGCTTTTCAGAGGCTGCGGACTTTCTTCCAGCCATTGTGGCATTGGCCTTTCCAG
TCTTGGGAGGAGCGCGCTGCTTTGGTGAGACACCCCCATGCAAGGTCCTCAGAGTAGCCGGGTTCTACCACAAACAGAAACAGAATGAAA
GTAGCTGTCAGTCCTTGTAGAGAGCCGCTCTGTTTCCTCCCAGAAGCATCTCCCAGCTAAGCTCGCATTATTTTTCTCCTCTGGCTGTTT
GCCTGAAGTTCACAGAACACACAACCATGAAAGGCTTTTTGAGGTGAGAGGCCCAGGTGGTCCTGGCAACCCTGAGTAGAAGGAGAGACG
GGGTAGGGAACGGGCCCGGCCAGAAAAGAACCATTTCTTCTGCCATCTTTTATGCACCATAGACATCGAGACTCCAGGGGGTCCTGGCTC
CCCTGTCCCTGCAGCCCTGCAGGTCAGTGCATGATCTGGGTTCGTGTCCTGACCAGGTGCTCCTCCTTTGATCCGAGGGGAAAGGGACTG
GTTTATAGAAAGAGCCTAGGAGACAAAAGGGCCAGTCCCCCTGCCCAGAATGGAGCAGCAGCAGGACAGACCCCCACGAGGCCCCCCAGA
GAGGAGGAAGATCCCACGGAGGAACACATGAGGTTAGGGACCCTTGTTCAGCACCCCAAACAGCCTGCCTGTTTAAAGCAGGCAGCAGGC
TTAGGCCTTCCCTGCAACCCCAACACCCACAAGTTTGTTTCTCTAGGAAACACATTCACTGTCTCAGCTGGCTGTTACTCTCTCAGACCA
TATGGCAAAGTTTTCCAAGAAAATGCCCCGACAGGGGTGCCCAGCACACTGCCTGAGGGACAACAGACATCAGAACAAACCCCCAGAGAG
AAACAGTCAAAATCAGGGCCCGGTGCAGTGTTGTCATGTGGAACCTGCTTTATCCATTGCTGAGTGTTGAATGTGGGTAATGGTTAGGGC
TTTCCAGATCTCAGCAGCCAAAGACAGTTATTGTTGGAAGACTGTCATGTAGATAACCATGAGCAATGGCTCGCCTCAGAATCAGTTCAT
AAAATTCTATGGTACTGGCCCCTTCGTGGGTATTGTGTGAAATGAGATGGTGGCGAGGGGTGCGCTGTGGAACTGCCGCAGCCACGCAGG
AGGTCCCTGGGGGATGCTTTGGGAAGTCCTTGCCCCTGAGCACTGCCTGATTGCCAGGGCCTGTGGAGGTCTAGGCCGCCTGGCAGAATC
TAGCACCGTCCGAATCCCCGCAGGACCCATGGAGCTATGACCACACCAGGCCATTCAAATGGCTCTGCATTATCTTCCCTTGGAAGGTGG
CCACTCCTCGGTGGCAGGGCCTTTCCCTGAGGCTGCAGGCCGTGGGCTGGCAGCCCGTCTCTTGGCATTTCAATTGAAGGTCACCAGGTG
CTGGGTTTGAAAGGAAGTCACTGGAGTGCTGCCAGGGGCCGCCCTCCAAGGTTAATGAGAGGCCCACATCCAGGCAAGAACTAATTCAAA
AGGCAGATCAGAAACCACAGGAGTCAAAATTATTGCTCCGGCAGTGCTTCCCTTCCTTTCATCCACTGGCCTCGTGTGGTCCATGCAGGG
CCACTGTCTGCCCTTTCTGATGCCACGTATTAGGCTTTCTTACTCAGAATTTTGATAGAAAACCATGGGGCCAAGAGCTCTGGAAGCCTG
GCCGGAAAGACCAAGGTTCATGCAGCCCAACAAATGATTGTTGAGCACCTCTCGGAGCCAAAGTCCTTAGGCGAGTGTGGTGACTTCCTG
GAAGGAGGATGCAGACTTCCAGAGAGCCCCCCCAACGGACGTGCTGAGAAGGGAGAGGGAGGCGGGGGCTGTAGTCAGGAAGGAGCCAGA
GAAGAACAGGGTTTGGGTGCATCCAGAAATATGCCTGCAGTAGGAGGGAGAGGAAGGGGTGCCACCGTCAACGGCTTCCCATCGGAGGTG
GTTGGTGCAGATGGAAGTTTCTGTCTGCTGGCCCTCAAGAGAGTGTTTTGCCAGGGACACAGTCTGTTCCTCCTCAGAAAACACCCCCCA
AATGCTAACAACATCCCCACCAGCTGCTAGAAGCCCCTTTCCCCTCCCCACCTTGAAGTAGCTCATAGTTCTCTGGGCAGAGCCAGACCA
TCCAGTGTACCCCAGAGGCCAGTAGGTTCCTGCCCATTTTCCTCTCTGGCTTCCTGCCAAGAATTATGGCAGCTGAGGATGAATGGAGAA
GTAAAAACAACTAACACCGCACAACTAACAACTAACACCGCAGTTCCCACCTGGGTTCCACTTAGCAGGAGACATTTCGGAGGGTTTTTT
TTGTTTTTGTTCCTGTTTTTTTTTTTTTTGCTGGAATTTGTTTTCTCAGTACTGAAAAGAGAAAAAGTGACAATCTTGTATTTTTAAAAG
CCTCGGAAAGGTGATACCATCTGACAGTCATTTTCTCACGTTGGTCTTCTAAAGTCACCTATTTCTTGTGTGTGCACATCACACCATTTC
CTGTTTCTTTATAACCCGACAAGGGTAGGAGTGCCTGTTTCCCCTGCTGGGCACACCAGACAATCGTAATCACAAAACAGACACTGAGCC
AGGGGCCCAAAGGGTGTGATCATGAGAGTTACCGGGACAGCAGTAGGCATGACAGTCACCAGGAAGGACAAGGGTGCTCTGTTGTTAGTG
GCCACACACCAATTTGACAAGGAGTGTTGCGAAATTTTTATTTATTTATTTATTTATTTTGAGATGGAGTTTCACTCTTGTTGCCCAGGC
TGGAGTGCGGTGGTACAATCTCGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTACCTGGGA
CTACAGGTGCGTGCCACCACACCCAGCTAAATTTTGTGTTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGATGGTCTTGAACCCC
TGACCTCATGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCCAAAATATTTTTTTAAAGTC
ATTTTCCTTAAGCTGCTTGGGCTACATGTGAAATACACTGGACGGTCAACATTCCTGTCTCCTCCCATTTGGGCTGATGCAGCAGATCCA
GGGAATGTTACCTGTTTCTGCTGCTAGAAGATCCAGGAAATTGGGAAGGTTACCTGACGCACACATGGATGAAGGCCATCATCTAGAAAT
GGGGTCAACCACAATTGTGTTAATTCCGTAGTGTCAGGGATTCTTCGGGAAGGTCAACAGTATGAAGGATTCTGACCCCTGTGCCTCCCA
TTTATGTGATCAGGTGACAGTTAATAACCGTGGAGGTCACACTCAGCCATCCAACAGCCTTACAGTGACCCTACACAAAAGCCCCCAAAT
TCCAAAGACTTTTTCTTAACCTAAAGGAAGAAATTATTTGTTAATTCCAGTAGAGCAACTGAATATACTGGGCTATTTGTACTTTTTTAT
AGAGAACTTTAATAATAATTCTTTAAAAATGAGTTTTTAGAACAAAGCAACTGACGATTTCCTAAGATTCCAATGCCCTGGAGCTTGTAG
GAGGACTTAGCCTGGGTCAGCTGGAGCACCCCCGACCTGATCTCCCACTGCCAGATTTTCCCATGCTCCTAGGGTATGGAGTCCACGTGG
GAATGACTGCAAGTTCAGGTGGAACTTGGCCGACTGATGCTCTGCGAGTTTTTAATAGACACTGGGGACAACTGCTTAAGGTTTAGAAAC
TTCCAAACCACAGGAAAGACATTTTTAGTGTCCCCCATCCAGAGGCAGCCCTGGAATAGGATTCCCAGGGGTTTCTGGGACCCCTTTCCT
TGCTCCGTGAGGCTCTGTGGCCATCTTTTGGCAGGAGGAGGATGCTTCCTTGGCTCTGTGCCCAGACCCGCCTGGTCCCCAGGTCTCTCA
CCTTGGGTGAAGATTCAGAGATGCCCTGTAAGGATTTTGCCCACTGGGCAACTCAGAAATACTTCGATCTCCCAAGATATAAGAGGCAGC
AGCAAACGTGCCTATTGACGTCTGTTTCATAGTTACCACTTACGCGAGTAGACAGAACTCGGCTTTTCAGAAAATAGGTGTCAAGTCCAC
TTTATAAGAACCTTTTTTTCTAAAATAAGATAAAAGGTGGCTTTGCATTTTCTGATTAAACGACTGTGTCTTTGTCACCTCTGCTTAACT
TTAGGAGTATCCATTCCTGTGATTGTAGACTTTTGTTGATATTCTTCCTGGAAGAATATCATTCTTTTCTTGAAGGGTTGGTTTACTAGA
ATATTCAAAATCAATCATGAAGGCAGTTACTATTTTGAGTCTAAAGGTTTTCTAAAAATTAACCTCACATCCCTTCTGTTAGGGTCTTTC
AGAATATCTTTTATAAACAGAAGCATTTGAAGTCATTGCTTTTGCTACATGATTTGTGTGTGTGAAGGACATACCACGTTTAAATCATTA
ATTGAAAAACATCATATAAGCCCCAACTTTGTTTGGAGGAAGAGACGGAGGTTGAGGTTTTTCCTTCTGTATAAGCACCTACTGACAAAA
TGTAGAGGCCATTCAACCGTCAAACACCATTTGGTTATATCGCAGAGGAGACGGATGTGTAAATTACTGCATTGCTTTTTTTTTCAGTTT
GTATAACCTCTAATCTCCGTTTGCATGATACGCTTTGTTAGAAACATTAATTGTAGTTTGGAAGCAAGTGTGTATGAATAAAGATAATGA

>In-frame_ENST00000357146_ENST00000413366_TCGA-C8-A12P-01A_PSMD12_chr17_65340722_-_PRKCA_chr17_64637473_length(amino acids)=917AA_start in transcript=86_stop in transcript=2839
MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCT
YVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYI
RTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRI
SGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVEHDPRSKHKFKIHTYGSPTFC
DHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPK
NESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDE
EGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTM
VEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEG
HIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEA
VSVCKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PSMD12-PRKCA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PSMD12-PRKCA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PSMD12-PRKCA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePSMD12C0011616Contact Dermatitis1CTD_human
HgenePSMD12C0162351Contact hypersensitivity1CTD_human
HgenePSMD12C4479599STANKIEWICZ-ISIDOR SYNDROME1GENOMICS_ENGLAND
TgenePRKCAC0036341Schizophrenia2PSYGENET
TgenePRKCAC0002152Alloxan Diabetes1CTD_human
TgenePRKCAC0011853Diabetes Mellitus, Experimental1CTD_human
TgenePRKCAC0018800Cardiomegaly1CTD_human
TgenePRKCAC0021841Intestinal Neoplasms1CTD_human
TgenePRKCAC0032617Polyuria1CTD_human
TgenePRKCAC0033975Psychotic Disorders1PSYGENET
TgenePRKCAC0036337Schizoaffective Disorder1PSYGENET
TgenePRKCAC0038433Streptozotocin Diabetes1CTD_human
TgenePRKCAC0162283Nephrogenic Diabetes Insipidus1CTD_human
TgenePRKCAC0264423Asthma, Occupational1CTD_human
TgenePRKCAC0268443Acquired Nephrogenic Diabetes Insipidus1CTD_human
TgenePRKCAC0346627Intestinal Cancer1CTD_human
TgenePRKCAC0349204Nonorganic psychosis1PSYGENET
TgenePRKCAC0400966Non-alcoholic Fatty Liver Disease1CTD_human
TgenePRKCAC0677501Congenital Nephrogenic Diabetes Insipidus1CTD_human
TgenePRKCAC1383860Cardiac Hypertrophy1CTD_human
TgenePRKCAC1563705Nephrogenic Diabetes Insipidus, Type I1CTD_human
TgenePRKCAC1563706Nephrogenic Diabetes Insipidus, Type II1CTD_human
TgenePRKCAC3241937Nonalcoholic Steatohepatitis1CTD_human
TgenePRKCAC3542500ADH-Resistant Diabetes Insipidus1CTD_human