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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:PTGDS-ITIH3 (FusionGDB2 ID:69512) |
Fusion Gene Summary for PTGDS-ITIH3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PTGDS-ITIH3 | Fusion gene ID: 69512 | Hgene | Tgene | Gene symbol | PTGDS | ITIH3 | Gene ID | 5730 | 3699 |
| Gene name | prostaglandin D2 synthase | inter-alpha-trypsin inhibitor heavy chain 3 | |
| Synonyms | L-PGDS|LPGDS|PDS|PGD2|PGDS|PGDS2 | H3P|ITI-HC3|SHAP | |
| Cytomap | 9q34.3 | 3p21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | prostaglandin-H2 D-isomerasePGD2 synthasebeta-trace proteincerebrin-28glutathione-independent PGD synthaseglutathione-independent PGD synthetaselipocalin-type prostaglandin D synthaseprostaglandin D synthaseprostaglandin D2 synthase 21kDa (brain) | inter-alpha-trypsin inhibitor heavy chain H3ITI heavy chain H3inter-alpha (globulin) inhibitor H3inter-alpha (globulin) inhibitor, H3 polypeptideinter-alpha-inhibitor heavy chain 3pre-alpha (globulin) inhibitor, H3 polypeptideserum-derived hyalurona | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q06033 | |
| Ensembl transtripts involved in fusion gene | ENST00000224167, ENST00000371625, ENST00000460340, | ENST00000416872, ENST00000449956, ENST00000465243, | |
| Fusion gene scores | * DoF score | 17 X 10 X 6=1020 | 2 X 3 X 2=12 |
| # samples | 19 | 2 | |
| ** MAII score | log2(19/1020*10)=-2.42449782852791 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/12*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PTGDS [Title/Abstract] AND ITIH3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | PTGDS(139872144)-ITIH3(52832982), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PTGDS | GO:0001516 | prostaglandin biosynthetic process | 20667974 |
| Fusion gene breakpoints across PTGDS (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across ITIH3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LIHC | TCGA-BC-A10R-01A | PTGDS | chr9 | 139872144 | + | ITIH3 | chr3 | 52832982 | + |
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Fusion Gene ORF analysis for PTGDS-ITIH3 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000224167 | ENST00000416872 | PTGDS | chr9 | 139872144 | + | ITIH3 | chr3 | 52832982 | + |
| In-frame | ENST00000224167 | ENST00000449956 | PTGDS | chr9 | 139872144 | + | ITIH3 | chr3 | 52832982 | + |
| 5CDS-3UTR | ENST00000224167 | ENST00000465243 | PTGDS | chr9 | 139872144 | + | ITIH3 | chr3 | 52832982 | + |
| In-frame | ENST00000371625 | ENST00000416872 | PTGDS | chr9 | 139872144 | + | ITIH3 | chr3 | 52832982 | + |
| In-frame | ENST00000371625 | ENST00000449956 | PTGDS | chr9 | 139872144 | + | ITIH3 | chr3 | 52832982 | + |
| 5CDS-3UTR | ENST00000371625 | ENST00000465243 | PTGDS | chr9 | 139872144 | + | ITIH3 | chr3 | 52832982 | + |
| intron-3CDS | ENST00000460340 | ENST00000416872 | PTGDS | chr9 | 139872144 | + | ITIH3 | chr3 | 52832982 | + |
| intron-3CDS | ENST00000460340 | ENST00000449956 | PTGDS | chr9 | 139872144 | + | ITIH3 | chr3 | 52832982 | + |
| intron-3UTR | ENST00000460340 | ENST00000465243 | PTGDS | chr9 | 139872144 | + | ITIH3 | chr3 | 52832982 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000224167 | PTGDS | chr9 | 139872144 | + | ENST00000416872 | ITIH3 | chr3 | 52832982 | + | 1738 | 189 | 36 | 1622 | 528 |
| ENST00000224167 | PTGDS | chr9 | 139872144 | + | ENST00000449956 | ITIH3 | chr3 | 52832982 | + | 2527 | 189 | 36 | 2198 | 720 |
| ENST00000371625 | PTGDS | chr9 | 139872144 | + | ENST00000416872 | ITIH3 | chr3 | 52832982 | + | 1737 | 188 | 35 | 1621 | 528 |
| ENST00000371625 | PTGDS | chr9 | 139872144 | + | ENST00000449956 | ITIH3 | chr3 | 52832982 | + | 2526 | 188 | 35 | 2197 | 720 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000224167 | ENST00000416872 | PTGDS | chr9 | 139872144 | + | ITIH3 | chr3 | 52832982 | + | 0.003823684 | 0.99617624 |
| ENST00000224167 | ENST00000449956 | PTGDS | chr9 | 139872144 | + | ITIH3 | chr3 | 52832982 | + | 0.007825116 | 0.9921748 |
| ENST00000371625 | ENST00000416872 | PTGDS | chr9 | 139872144 | + | ITIH3 | chr3 | 52832982 | + | 0.003775647 | 0.9962244 |
| ENST00000371625 | ENST00000449956 | PTGDS | chr9 | 139872144 | + | ITIH3 | chr3 | 52832982 | + | 0.00776148 | 0.9922386 |
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Fusion Genomic Features for PTGDS-ITIH3 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| PTGDS | chr9 | 139872144 | + | ITIH3 | chr3 | 52832981 | + | 0.55547315 | 0.44452682 |
| PTGDS | chr9 | 139872144 | + | ITIH3 | chr3 | 52832981 | + | 0.55547315 | 0.44452682 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for PTGDS-ITIH3 |
| Go to FGviewer for the breakpoints of chr9:139872144-chr3:52832982 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | ITIH3 |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ITIH3 | chr9:139872144 | chr3:52832982 | ENST00000449956 | 5 | 22 | 284_467 | 221.0 | 891.0 | Domain | VWFA |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ITIH3 | chr9:139872144 | chr3:52832982 | ENST00000449956 | 5 | 22 | 29_158 | 221.0 | 891.0 | Domain | VIT |
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Fusion Gene Sequence for PTGDS-ITIH3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000224167_ENST00000416872_TCGA-BC-A10R-01A_PTGDS_chr9_139872144_+_ITIH3_chr3_52832982_length(transcript)=1738nt_BP=189nt GCTCCTCCTGCACACCTCCCTCGCTCTCCCACACCACTGGCACCAGGCCCCGGACACCCGCTCTGCTGCAGGAGAATGGCTACTCATCAC ACACTGTGGATGGGACTGGCCCTGCTGGGGGTGCTGGGCGACCTGCAGGCAGCACCGGAGGCCCAGGTCTCCGTGCAGCCCAACTTCCAG CAGGACAAGGGCCATGTGTCCTTCAAGCCCAGCTTAGACCAACAGCGTTCATGCCCAACCTGTACAGACTCCCTCCTCAATGGAGATTTC ACTATCACCTATGACGTGAACAGAGAATCTCCTGGCAACGTGCAGATAGTCAATGGCTACTTCGTGCACTTCTTTGCACCTCAAGGCCTT CCAGTGGTGCCTAAGAACGTGGCCTTTGTGATTGACATCAGCGGCTCCATGGCTGGTCGGAAATTAGAGCAGACAAAGGAGGCCCTTCTC AGAATCCTGGAAGATATGCAAGAGGAAGACTATCTGAATTTCATCCTGTTCAGTGGAGATGTGTCCACATGGAAAGAGCACTTAGTCCAG GCCACGCCCGAGAACCTCCAGGAGGCCAGGACGTTTGTGAAGAGCATGGAGGATAAAGGAATGACCAACATCAATGACGGGCTGCTGAGG GGCATCAGTATGCTGAACAAGGCCCGAGAGGAGCACAGAATCCCAGAGAGGAGCACCTCCATTGTCATCATGCTGACTGATGGGGATGCC AATGTTGGTGAGAGCAGACCCGAAAAAATCCAAGAGAATGTGCGGAATGCCATCGGGGGCAAGTTCCCCTTGTATAACCTGGGCTTTGGC AACAATCTGAATTATAACTTCCTGGAGAACATGGCCCTGGAGAACCATGGGTTTGCCCGGCGCATTTATGAGGACTCTGATGCCGATTTG CAGTTGCAGGGCTTCTATGAGGAGGTGGCCAACCCACTGCTGACGGGTGTGGAGATGGAGTACCCCGAGAACGCTATCCTGGACCTCACC CAGAACACTTACCAGCACTTCTACGATGGCTCTGAGATCGTGGTGGCCGGGCGCCTGGTGGACGAGGACATGAACAGCTTTAAGGCAGAT GTGAAGGGCCATGGGGCCACCAACGACCTGACCTTCACAGAGGAGGTGACAACGGAGAAGATCACCCTGTGGAACAGGGCCGTGCCGAGC ACTTTCAGCTGGCTGGACACAGTCACAGTCACGCAGGATGGGCTGTCCATGATGATCAACAGGAAGAACATGGTGGTCTCCTTTGGAGAT GGGGTTACCTTCGTGGTCGTCCTACACCAGGTGTGGAAGAAACATCCTGTCCACCGTGACTTTCTAGGCTTCTACGTGGTGGACAGTCAC CGGATGTCAGCACAGACGCATGGGCTGCTGGGGCAATTCTTCCAACCCTTTGACTTTAAAGTGTCTGACATCCGGCCAGGCTCTGACCCC ACAAAGCCAGATGCCACATTGGTGGTGAAGAACCATCAGCTGATTGTCACCAGGGGCTCCCAGAAAGACTACAGAAAGGATGCCAGCATC GGCACGAAGGTTGTCTGCTGGTTCGTCCACAACAACGGAGAAGGGCTGATTGATGGTGTCCACACTGACTACATTGTCCCCAACCTGTTT TGAGTAGACACACCAGCTCCTGTTGGGATGGATGGCCCGGATTTTATGGCATCTGGAACATGGGCACAGAGAGGGGCCTGTGGGAGGGGC >In-frame_ENST00000224167_ENST00000416872_TCGA-BC-A10R-01A_PTGDS_chr9_139872144_+_ITIH3_chr3_52832982_length(amino acids)=528AA_start in transcript=36_stop in transcript=1622 MAPGPGHPLCCRRMATHHTLWMGLALLGVLGDLQAAPEAQVSVQPNFQQDKGHVSFKPSLDQQRSCPTCTDSLLNGDFTITYDVNRESPG NVQIVNGYFVHFFAPQGLPVVPKNVAFVIDISGSMAGRKLEQTKEALLRILEDMQEEDYLNFILFSGDVSTWKEHLVQATPENLQEARTF VKSMEDKGMTNINDGLLRGISMLNKAREEHRIPERSTSIVIMLTDGDANVGESRPEKIQENVRNAIGGKFPLYNLGFGNNLNYNFLENMA LENHGFARRIYEDSDADLQLQGFYEEVANPLLTGVEMEYPENAILDLTQNTYQHFYDGSEIVVAGRLVDEDMNSFKADVKGHGATNDLTF TEEVTTEKITLWNRAVPSTFSWLDTVTVTQDGLSMMINRKNMVVSFGDGVTFVVVLHQVWKKHPVHRDFLGFYVVDSHRMSAQTHGLLGQ -------------------------------------------------------------- >In-frame_ENST00000224167_ENST00000449956_TCGA-BC-A10R-01A_PTGDS_chr9_139872144_+_ITIH3_chr3_52832982_length(transcript)=2527nt_BP=189nt GCTCCTCCTGCACACCTCCCTCGCTCTCCCACACCACTGGCACCAGGCCCCGGACACCCGCTCTGCTGCAGGAGAATGGCTACTCATCAC ACACTGTGGATGGGACTGGCCCTGCTGGGGGTGCTGGGCGACCTGCAGGCAGCACCGGAGGCCCAGGTCTCCGTGCAGCCCAACTTCCAG CAGGACAAGGGCCATGTGTCCTTCAAGCCCAGCTTAGACCAACAGCGTTCATGCCCAACCTGTACAGACTCCCTCCTCAATGGAGATTTC ACTATCACCTATGACGTGAACAGAGAATCTCCTGGCAACGTGCAGATAGTCAATGGCTACTTCGTGCACTTCTTTGCACCTCAAGGCCTT CCAGTGGTGCCTAAGAACGTGGCCTTTGTGATTGACATCAGCGGCTCCATGGCTGGTCGGAAATTAGAGCAGACAAAGGAGGCCCTTCTC AGAATCCTGGAAGATATGCAAGAGGAAGACTATCTGAATTTCATCCTGTTCAGTGGAGATGTGTCCACATGGAAAGAGCACTTAGTCCAG GCCACGCCCGAGAACCTCCAGGAGGCCAGGACGTTTGTGAAGAGCATGGAGGATAAAGGAATGACCAACATCAATGACGGGCTGCTGAGG GGCATCAGTATGCTGAACAAGGCCCGAGAGGAGCACAGAATCCCAGAGAGGAGCACCTCCATTGTCATCATGCTGACTGATGGGGATGCC AATGTTGGTGAGAGCAGACCCGAAAAAATCCAAGAGAATGTGCGGAATGCCATCGGGGGCAAGTTCCCCTTGTATAACCTGGGCTTTGGC AACAATCTGAATTATAACTTCCTGGAGAACATGGCCCTGGAGAACCATGGGTTTGCCCGGCGCATTTATGAGGACTCTGATGCCGATTTG CAGTTGCAGGGCTTCTATGAGGAGGTGGCCAACCCACTGCTGACGGGTGTGGAGATGGAGTACCCCGAGAACGCTATCCTGGACCTCACC CAGAACACTTACCAGCACTTCTACGATGGCTCTGAGATCGTGGTGGCCGGGCGCCTGGTGGACGAGGACATGAACAGCTTTAAGGCAGAT GTGAAGGGCCATGGGGCCACCAACGACCTGACCTTCACAGAGGAGGTGGACATGAAGGAGATGGAGAAGGCCCTGCAGGAGCGGGACTAC ATCTTCGGGAATTACATTGAGCGGCTCTGGGCCTACCTCACCATTGAGCAGCTGCTGGAGAAGCGCAAGAACGCCCATGGCGAGGAGAAG GAGAACCTCACGGCCCGGGCCCTGGACCTGTCCCTCAAGTATCACTTTGTGACTCCACTGACCTCAATGGTGGTGACCAAGCCTGAGGAC AACGAGGATGAGAGGGCCATTGCCGACAAGCCTGGGGAAGATGCAGAAGCCACACCGGTGAGCCCCGCCATGTCCTACCTGACCAGCTAC CAGCCTCCTCAAAACCCCTACTACTATGTGGACGGGGATCCCCACTTCATCATCCAAATTCCGGAGAAAGACGATGCCCTCTGCTTCAAC ATCGATGAAGCCCCAGGCACAGTGCTGCGCCTTATTCAGGATGCAGTCACAGGCCTCACAGTTAATGGGCAGATCACTGGCGACAAGAGA GGCAGCCCTGACTCCAAGACCAGAAAGACTTACTTTGGAAAACTGGGCATCGCCAATGCTCAGATGGACTTCCAGGTGGAGGTGACAACG GAGAAGATCACCCTGTGGAACAGGGCCGTGCCGAGCACTTTCAGCTGGCTGGACACAGTCACAGTCACGCAGGATGGGCTGTCCATGATG ATCAACAGGAAGAACATGGTGGTCTCCTTTGGAGATGGGGTTACCTTCGTGGTCGTCCTACACCAGGTGTGGAAGAAACATCCTGTCCAC CGTGACTTTCTAGGCTTCTACGTGGTGGACAGTCACCGGATGTCAGCACAGACGCATGGGCTGCTGGGGCAATTCTTCCAACCCTTTGAC TTTAAAGTGTCTGACATCCGGCCAGGCTCTGACCCCACAAAGCCAGATGCCACATTGGTGGTGAAGAACCATCAGCTGATTGTCACCAGG GGCTCCCAGAAAGACTACAGAAAGGATGCCAGCATCGGCACGAAGGTTGTCTGCTGGTTCGTCCACAACAACGGAGAAGGGCTGATTGAT GGTGTCCACACTGACTACATTGTCCCCAACCTGTTTTGAGTAGACACACCAGCTCCTGTTGGGATGGATGGCCCGGATTTTATGGCATCT GGAACATGGGCACAGAGAGGGGCCTGTGGGAGGGGCTGGGAAAATAAAGTCCAAGGTCGAGACCAGACAGCTGCCAGCCTCTACATGCCT TCATGAGCCTCTGCTCCAGGGAACAGGCAACTGGGACCCACAGCAGCTCAAAAGAGGGGATGGCTAGCAGGAAGGCAACTTCTTGGGCCT CTCCACTGACACAGCTGAGAGACAGAGTTGGTTGGACTAGAACTTTAGGGATTCAAATGTATGACAGCTTGGGGGAAAAAATAAAGAACT >In-frame_ENST00000224167_ENST00000449956_TCGA-BC-A10R-01A_PTGDS_chr9_139872144_+_ITIH3_chr3_52832982_length(amino acids)=720AA_start in transcript=36_stop in transcript=2198 MAPGPGHPLCCRRMATHHTLWMGLALLGVLGDLQAAPEAQVSVQPNFQQDKGHVSFKPSLDQQRSCPTCTDSLLNGDFTITYDVNRESPG NVQIVNGYFVHFFAPQGLPVVPKNVAFVIDISGSMAGRKLEQTKEALLRILEDMQEEDYLNFILFSGDVSTWKEHLVQATPENLQEARTF VKSMEDKGMTNINDGLLRGISMLNKAREEHRIPERSTSIVIMLTDGDANVGESRPEKIQENVRNAIGGKFPLYNLGFGNNLNYNFLENMA LENHGFARRIYEDSDADLQLQGFYEEVANPLLTGVEMEYPENAILDLTQNTYQHFYDGSEIVVAGRLVDEDMNSFKADVKGHGATNDLTF TEEVDMKEMEKALQERDYIFGNYIERLWAYLTIEQLLEKRKNAHGEEKENLTARALDLSLKYHFVTPLTSMVVTKPEDNEDERAIADKPG EDAEATPVSPAMSYLTSYQPPQNPYYYVDGDPHFIIQIPEKDDALCFNIDEAPGTVLRLIQDAVTGLTVNGQITGDKRGSPDSKTRKTYF GKLGIANAQMDFQVEVTTEKITLWNRAVPSTFSWLDTVTVTQDGLSMMINRKNMVVSFGDGVTFVVVLHQVWKKHPVHRDFLGFYVVDSH RMSAQTHGLLGQFFQPFDFKVSDIRPGSDPTKPDATLVVKNHQLIVTRGSQKDYRKDASIGTKVVCWFVHNNGEGLIDGVHTDYIVPNLF -------------------------------------------------------------- >In-frame_ENST00000371625_ENST00000416872_TCGA-BC-A10R-01A_PTGDS_chr9_139872144_+_ITIH3_chr3_52832982_length(transcript)=1737nt_BP=188nt CTCCTCCTGCACACCTCCCTCGCTCTCCCACACCACTGGCACCAGGCCCCGGACACCCGCTCTGCTGCAGGAGAATGGCTACTCATCACA CACTGTGGATGGGACTGGCCCTGCTGGGGGTGCTGGGCGACCTGCAGGCAGCACCGGAGGCCCAGGTCTCCGTGCAGCCCAACTTCCAGC AGGACAAGGGCCATGTGTCCTTCAAGCCCAGCTTAGACCAACAGCGTTCATGCCCAACCTGTACAGACTCCCTCCTCAATGGAGATTTCA CTATCACCTATGACGTGAACAGAGAATCTCCTGGCAACGTGCAGATAGTCAATGGCTACTTCGTGCACTTCTTTGCACCTCAAGGCCTTC CAGTGGTGCCTAAGAACGTGGCCTTTGTGATTGACATCAGCGGCTCCATGGCTGGTCGGAAATTAGAGCAGACAAAGGAGGCCCTTCTCA GAATCCTGGAAGATATGCAAGAGGAAGACTATCTGAATTTCATCCTGTTCAGTGGAGATGTGTCCACATGGAAAGAGCACTTAGTCCAGG CCACGCCCGAGAACCTCCAGGAGGCCAGGACGTTTGTGAAGAGCATGGAGGATAAAGGAATGACCAACATCAATGACGGGCTGCTGAGGG GCATCAGTATGCTGAACAAGGCCCGAGAGGAGCACAGAATCCCAGAGAGGAGCACCTCCATTGTCATCATGCTGACTGATGGGGATGCCA ATGTTGGTGAGAGCAGACCCGAAAAAATCCAAGAGAATGTGCGGAATGCCATCGGGGGCAAGTTCCCCTTGTATAACCTGGGCTTTGGCA ACAATCTGAATTATAACTTCCTGGAGAACATGGCCCTGGAGAACCATGGGTTTGCCCGGCGCATTTATGAGGACTCTGATGCCGATTTGC AGTTGCAGGGCTTCTATGAGGAGGTGGCCAACCCACTGCTGACGGGTGTGGAGATGGAGTACCCCGAGAACGCTATCCTGGACCTCACCC AGAACACTTACCAGCACTTCTACGATGGCTCTGAGATCGTGGTGGCCGGGCGCCTGGTGGACGAGGACATGAACAGCTTTAAGGCAGATG TGAAGGGCCATGGGGCCACCAACGACCTGACCTTCACAGAGGAGGTGACAACGGAGAAGATCACCCTGTGGAACAGGGCCGTGCCGAGCA CTTTCAGCTGGCTGGACACAGTCACAGTCACGCAGGATGGGCTGTCCATGATGATCAACAGGAAGAACATGGTGGTCTCCTTTGGAGATG GGGTTACCTTCGTGGTCGTCCTACACCAGGTGTGGAAGAAACATCCTGTCCACCGTGACTTTCTAGGCTTCTACGTGGTGGACAGTCACC GGATGTCAGCACAGACGCATGGGCTGCTGGGGCAATTCTTCCAACCCTTTGACTTTAAAGTGTCTGACATCCGGCCAGGCTCTGACCCCA CAAAGCCAGATGCCACATTGGTGGTGAAGAACCATCAGCTGATTGTCACCAGGGGCTCCCAGAAAGACTACAGAAAGGATGCCAGCATCG GCACGAAGGTTGTCTGCTGGTTCGTCCACAACAACGGAGAAGGGCTGATTGATGGTGTCCACACTGACTACATTGTCCCCAACCTGTTTT GAGTAGACACACCAGCTCCTGTTGGGATGGATGGCCCGGATTTTATGGCATCTGGAACATGGGCACAGAGAGGGGCCTGTGGGAGGGGCT >In-frame_ENST00000371625_ENST00000416872_TCGA-BC-A10R-01A_PTGDS_chr9_139872144_+_ITIH3_chr3_52832982_length(amino acids)=528AA_start in transcript=35_stop in transcript=1621 MAPGPGHPLCCRRMATHHTLWMGLALLGVLGDLQAAPEAQVSVQPNFQQDKGHVSFKPSLDQQRSCPTCTDSLLNGDFTITYDVNRESPG NVQIVNGYFVHFFAPQGLPVVPKNVAFVIDISGSMAGRKLEQTKEALLRILEDMQEEDYLNFILFSGDVSTWKEHLVQATPENLQEARTF VKSMEDKGMTNINDGLLRGISMLNKAREEHRIPERSTSIVIMLTDGDANVGESRPEKIQENVRNAIGGKFPLYNLGFGNNLNYNFLENMA LENHGFARRIYEDSDADLQLQGFYEEVANPLLTGVEMEYPENAILDLTQNTYQHFYDGSEIVVAGRLVDEDMNSFKADVKGHGATNDLTF TEEVTTEKITLWNRAVPSTFSWLDTVTVTQDGLSMMINRKNMVVSFGDGVTFVVVLHQVWKKHPVHRDFLGFYVVDSHRMSAQTHGLLGQ -------------------------------------------------------------- >In-frame_ENST00000371625_ENST00000449956_TCGA-BC-A10R-01A_PTGDS_chr9_139872144_+_ITIH3_chr3_52832982_length(transcript)=2526nt_BP=188nt CTCCTCCTGCACACCTCCCTCGCTCTCCCACACCACTGGCACCAGGCCCCGGACACCCGCTCTGCTGCAGGAGAATGGCTACTCATCACA CACTGTGGATGGGACTGGCCCTGCTGGGGGTGCTGGGCGACCTGCAGGCAGCACCGGAGGCCCAGGTCTCCGTGCAGCCCAACTTCCAGC AGGACAAGGGCCATGTGTCCTTCAAGCCCAGCTTAGACCAACAGCGTTCATGCCCAACCTGTACAGACTCCCTCCTCAATGGAGATTTCA CTATCACCTATGACGTGAACAGAGAATCTCCTGGCAACGTGCAGATAGTCAATGGCTACTTCGTGCACTTCTTTGCACCTCAAGGCCTTC CAGTGGTGCCTAAGAACGTGGCCTTTGTGATTGACATCAGCGGCTCCATGGCTGGTCGGAAATTAGAGCAGACAAAGGAGGCCCTTCTCA GAATCCTGGAAGATATGCAAGAGGAAGACTATCTGAATTTCATCCTGTTCAGTGGAGATGTGTCCACATGGAAAGAGCACTTAGTCCAGG CCACGCCCGAGAACCTCCAGGAGGCCAGGACGTTTGTGAAGAGCATGGAGGATAAAGGAATGACCAACATCAATGACGGGCTGCTGAGGG GCATCAGTATGCTGAACAAGGCCCGAGAGGAGCACAGAATCCCAGAGAGGAGCACCTCCATTGTCATCATGCTGACTGATGGGGATGCCA ATGTTGGTGAGAGCAGACCCGAAAAAATCCAAGAGAATGTGCGGAATGCCATCGGGGGCAAGTTCCCCTTGTATAACCTGGGCTTTGGCA ACAATCTGAATTATAACTTCCTGGAGAACATGGCCCTGGAGAACCATGGGTTTGCCCGGCGCATTTATGAGGACTCTGATGCCGATTTGC AGTTGCAGGGCTTCTATGAGGAGGTGGCCAACCCACTGCTGACGGGTGTGGAGATGGAGTACCCCGAGAACGCTATCCTGGACCTCACCC AGAACACTTACCAGCACTTCTACGATGGCTCTGAGATCGTGGTGGCCGGGCGCCTGGTGGACGAGGACATGAACAGCTTTAAGGCAGATG TGAAGGGCCATGGGGCCACCAACGACCTGACCTTCACAGAGGAGGTGGACATGAAGGAGATGGAGAAGGCCCTGCAGGAGCGGGACTACA TCTTCGGGAATTACATTGAGCGGCTCTGGGCCTACCTCACCATTGAGCAGCTGCTGGAGAAGCGCAAGAACGCCCATGGCGAGGAGAAGG AGAACCTCACGGCCCGGGCCCTGGACCTGTCCCTCAAGTATCACTTTGTGACTCCACTGACCTCAATGGTGGTGACCAAGCCTGAGGACA ACGAGGATGAGAGGGCCATTGCCGACAAGCCTGGGGAAGATGCAGAAGCCACACCGGTGAGCCCCGCCATGTCCTACCTGACCAGCTACC AGCCTCCTCAAAACCCCTACTACTATGTGGACGGGGATCCCCACTTCATCATCCAAATTCCGGAGAAAGACGATGCCCTCTGCTTCAACA TCGATGAAGCCCCAGGCACAGTGCTGCGCCTTATTCAGGATGCAGTCACAGGCCTCACAGTTAATGGGCAGATCACTGGCGACAAGAGAG GCAGCCCTGACTCCAAGACCAGAAAGACTTACTTTGGAAAACTGGGCATCGCCAATGCTCAGATGGACTTCCAGGTGGAGGTGACAACGG AGAAGATCACCCTGTGGAACAGGGCCGTGCCGAGCACTTTCAGCTGGCTGGACACAGTCACAGTCACGCAGGATGGGCTGTCCATGATGA TCAACAGGAAGAACATGGTGGTCTCCTTTGGAGATGGGGTTACCTTCGTGGTCGTCCTACACCAGGTGTGGAAGAAACATCCTGTCCACC GTGACTTTCTAGGCTTCTACGTGGTGGACAGTCACCGGATGTCAGCACAGACGCATGGGCTGCTGGGGCAATTCTTCCAACCCTTTGACT TTAAAGTGTCTGACATCCGGCCAGGCTCTGACCCCACAAAGCCAGATGCCACATTGGTGGTGAAGAACCATCAGCTGATTGTCACCAGGG GCTCCCAGAAAGACTACAGAAAGGATGCCAGCATCGGCACGAAGGTTGTCTGCTGGTTCGTCCACAACAACGGAGAAGGGCTGATTGATG GTGTCCACACTGACTACATTGTCCCCAACCTGTTTTGAGTAGACACACCAGCTCCTGTTGGGATGGATGGCCCGGATTTTATGGCATCTG GAACATGGGCACAGAGAGGGGCCTGTGGGAGGGGCTGGGAAAATAAAGTCCAAGGTCGAGACCAGACAGCTGCCAGCCTCTACATGCCTT CATGAGCCTCTGCTCCAGGGAACAGGCAACTGGGACCCACAGCAGCTCAAAAGAGGGGATGGCTAGCAGGAAGGCAACTTCTTGGGCCTC TCCACTGACACAGCTGAGAGACAGAGTTGGTTGGACTAGAACTTTAGGGATTCAAATGTATGACAGCTTGGGGGAAAAAATAAAGAACTG >In-frame_ENST00000371625_ENST00000449956_TCGA-BC-A10R-01A_PTGDS_chr9_139872144_+_ITIH3_chr3_52832982_length(amino acids)=720AA_start in transcript=35_stop in transcript=2197 MAPGPGHPLCCRRMATHHTLWMGLALLGVLGDLQAAPEAQVSVQPNFQQDKGHVSFKPSLDQQRSCPTCTDSLLNGDFTITYDVNRESPG NVQIVNGYFVHFFAPQGLPVVPKNVAFVIDISGSMAGRKLEQTKEALLRILEDMQEEDYLNFILFSGDVSTWKEHLVQATPENLQEARTF VKSMEDKGMTNINDGLLRGISMLNKAREEHRIPERSTSIVIMLTDGDANVGESRPEKIQENVRNAIGGKFPLYNLGFGNNLNYNFLENMA LENHGFARRIYEDSDADLQLQGFYEEVANPLLTGVEMEYPENAILDLTQNTYQHFYDGSEIVVAGRLVDEDMNSFKADVKGHGATNDLTF TEEVDMKEMEKALQERDYIFGNYIERLWAYLTIEQLLEKRKNAHGEEKENLTARALDLSLKYHFVTPLTSMVVTKPEDNEDERAIADKPG EDAEATPVSPAMSYLTSYQPPQNPYYYVDGDPHFIIQIPEKDDALCFNIDEAPGTVLRLIQDAVTGLTVNGQITGDKRGSPDSKTRKTYF GKLGIANAQMDFQVEVTTEKITLWNRAVPSTFSWLDTVTVTQDGLSMMINRKNMVVSFGDGVTFVVVLHQVWKKHPVHRDFLGFYVVDSH RMSAQTHGLLGQFFQPFDFKVSDIRPGSDPTKPDATLVVKNHQLIVTRGSQKDYRKDASIGTKVVCWFVHNNGEGLIDGVHTDYIVPNLF -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for PTGDS-ITIH3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for PTGDS-ITIH3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | ITIH3 | Q06033 | DB14548 | Zinc sulfate, unspecified form | Binder | Small molecule | Approved|Experimental |
| Tgene | ITIH3 | Q06033 | DB01593 | Zinc | Small molecule | Approved|Investigational | |
| Tgene | ITIH3 | Q06033 | DB14487 | Zinc acetate | Small molecule | Approved|Investigational | |
| Tgene | ITIH3 | Q06033 | DB14533 | Zinc chloride | Binder | Small molecule | Approved|Investigational |
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Related Diseases for PTGDS-ITIH3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PTGDS | C0005586 | Bipolar Disorder | 2 | PSYGENET |
| Tgene | ITIH3 | C0005586 | Bipolar Disorder | 4 | PSYGENET |
| Tgene | ITIH3 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | ITIH3 | C2239176 | Liver carcinoma | 1 | CTD_human |
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