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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:PTK2-MYO16 (FusionGDB2 ID:69601)

Fusion Gene Summary for PTK2-MYO16

Fusion gene summary

Fusion gene information	Fusion gene name: PTK2-MYO16
	Fusion gene ID: 69601
		Hgene	Tgene
	Gene symbol	PTK2	MYO16
	Gene ID	5747	23026
	Gene name	protein tyrosine kinase 2	myosin XVI
	Synonyms	FADK\|FAK\|FAK1\|FRNK\|PPP1R71\|p125FAK\|pp125FAK	MYAP3\|MYR8\|Myo16b\|NYAP3\|PPP1R107
	Cytomap	8q24.3	13q33.3
	Type of gene	protein-coding	protein-coding
	Description	focal adhesion kinase 1FADK 1FAK-related non-kinase polypeptidePTK2 protein tyrosine kinase 2focal adhesion kinase isoform FAK-Del33focal adhesion kinase-related nonkinaseprotein phosphatase 1 regulatory subunit 71	unconventional myosin-XVIMYO16 variant proteinmyosin heavy chain Myr 8neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 3protein phosphatase 1, regulatory subunit 10
	Modification date	20200327	20200313
	UniProtAcc	.	Q9Y6X6
	Ensembl transtripts involved in fusion gene	ENST00000522684, ENST00000535192, ENST00000519465, ENST00000517887, ENST00000521059, ENST00000395218, ENST00000538769, ENST00000340930, ENST00000519419, ENST00000430260, ENST00000519881, ENST00000520892, ENST00000519635, ENST00000517712, ENST00000522950, ENST00000520151,	ENST00000356711, ENST00000251041, ENST00000357550, ENST00000457511, ENST00000467639,
Fusion gene scores	* DoF score	39 X 32 X 15=18720	18 X 19 X 10=3420
	# samples	57	21
	** MAII score	log2(57/18720*10)=-5.03747470541866 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(21/3420*10)=-4.02553509210714 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PTK2 [Title/Abstract] AND MYO16 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	PTK2(141993941)-MYO16(109699264), # samples:1 PTK2(142011224)-MYO16(109699264), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PTK2	GO:0007179	transforming growth factor beta receptor signaling pathway	24036928
Hgene	PTK2	GO:0007229	integrin-mediated signaling pathway	24036928
Hgene	PTK2	GO:0010763	positive regulation of fibroblast migration	26763945
Hgene	PTK2	GO:0018108	peptidyl-tyrosine phosphorylation	10655584\|11331870
Hgene	PTK2	GO:0022408	negative regulation of cell-cell adhesion	21703394
Hgene	PTK2	GO:0030335	positive regulation of cell migration	11331870\|21703394
Hgene	PTK2	GO:0033628	regulation of cell adhesion mediated by integrin	10655584
Hgene	PTK2	GO:0046777	protein autophosphorylation	10655584\|11331870
Hgene	PTK2	GO:0048013	ephrin receptor signaling pathway	10655584
Hgene	PTK2	GO:0060396	growth hormone receptor signaling pathway	10925297
Hgene	PTK2	GO:0090303	positive regulation of wound healing	26763945

Fusion gene breakpoints across PTK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MYO16 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8683-01A	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
ChimerDB4	STAD	TCGA-BR-8683-01A	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+

Top

Fusion Gene ORF analysis for PTK2-MYO16

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000522684	ENST00000356711	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000522684	ENST00000251041	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000522684	ENST00000357550	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000522684	ENST00000457511	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-intron	ENST00000522684	ENST00000467639	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000535192	ENST00000356711	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000535192	ENST00000251041	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000535192	ENST00000357550	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000535192	ENST00000457511	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-intron	ENST00000535192	ENST00000467639	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000519465	ENST00000356711	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000519465	ENST00000251041	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000519465	ENST00000357550	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000519465	ENST00000457511	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-intron	ENST00000519465	ENST00000467639	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000517887	ENST00000356711	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000517887	ENST00000251041	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000517887	ENST00000357550	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000517887	ENST00000457511	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-intron	ENST00000517887	ENST00000467639	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000521059	ENST00000356711	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000521059	ENST00000251041	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000521059	ENST00000357550	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000521059	ENST00000457511	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-intron	ENST00000521059	ENST00000467639	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000395218	ENST00000356711	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000395218	ENST00000251041	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000395218	ENST00000357550	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000395218	ENST00000457511	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-intron	ENST00000395218	ENST00000467639	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000538769	ENST00000356711	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000538769	ENST00000251041	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000538769	ENST00000357550	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000538769	ENST00000457511	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-intron	ENST00000538769	ENST00000467639	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000340930	ENST00000356711	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000340930	ENST00000251041	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000340930	ENST00000357550	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000340930	ENST00000457511	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-intron	ENST00000340930	ENST00000467639	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000519419	ENST00000356711	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000519419	ENST00000251041	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000519419	ENST00000357550	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000519419	ENST00000457511	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-intron	ENST00000519419	ENST00000467639	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000430260	ENST00000356711	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000430260	ENST00000251041	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000430260	ENST00000357550	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000430260	ENST00000457511	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-intron	ENST00000430260	ENST00000467639	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000519881	ENST00000356711	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000519881	ENST00000251041	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000519881	ENST00000357550	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000519881	ENST00000457511	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-intron	ENST00000519881	ENST00000467639	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000520892	ENST00000356711	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000520892	ENST00000251041	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000520892	ENST00000357550	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000520892	ENST00000457511	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-intron	ENST00000520892	ENST00000467639	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
5UTR-3CDS	ENST00000519635	ENST00000356711	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
5UTR-3CDS	ENST00000519635	ENST00000251041	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
5UTR-3CDS	ENST00000519635	ENST00000357550	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
5UTR-3CDS	ENST00000519635	ENST00000457511	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
5UTR-intron	ENST00000519635	ENST00000467639	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000517712	ENST00000356711	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000517712	ENST00000251041	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000517712	ENST00000357550	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000517712	ENST00000457511	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-intron	ENST00000517712	ENST00000467639	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000522950	ENST00000356711	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000522950	ENST00000251041	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000522950	ENST00000357550	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000522950	ENST00000457511	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-intron	ENST00000522950	ENST00000467639	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000520151	ENST00000356711	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000520151	ENST00000251041	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000520151	ENST00000357550	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000520151	ENST00000457511	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
intron-intron	ENST00000520151	ENST00000467639	PTK2	chr8	141993941	-	MYO16	chr13	109699264	+
5UTR-3CDS	ENST00000522684	ENST00000356711	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
5UTR-3CDS	ENST00000522684	ENST00000251041	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
5UTR-3CDS	ENST00000522684	ENST00000357550	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
5UTR-3CDS	ENST00000522684	ENST00000457511	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
5UTR-intron	ENST00000522684	ENST00000467639	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000535192	ENST00000356711	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000535192	ENST00000251041	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000535192	ENST00000357550	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000535192	ENST00000457511	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-intron	ENST00000535192	ENST00000467639	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000519465	ENST00000356711	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000519465	ENST00000251041	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000519465	ENST00000357550	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000519465	ENST00000457511	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-intron	ENST00000519465	ENST00000467639	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000517887	ENST00000356711	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000517887	ENST00000251041	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000517887	ENST00000357550	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000517887	ENST00000457511	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-intron	ENST00000517887	ENST00000467639	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
5UTR-3CDS	ENST00000521059	ENST00000356711	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
5UTR-3CDS	ENST00000521059	ENST00000251041	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
5UTR-3CDS	ENST00000521059	ENST00000357550	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
5UTR-3CDS	ENST00000521059	ENST00000457511	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
5UTR-intron	ENST00000521059	ENST00000467639	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
5UTR-3CDS	ENST00000395218	ENST00000356711	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
5UTR-3CDS	ENST00000395218	ENST00000251041	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
5UTR-3CDS	ENST00000395218	ENST00000357550	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
5UTR-3CDS	ENST00000395218	ENST00000457511	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
5UTR-intron	ENST00000395218	ENST00000467639	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000538769	ENST00000356711	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000538769	ENST00000251041	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000538769	ENST00000357550	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000538769	ENST00000457511	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-intron	ENST00000538769	ENST00000467639	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
5UTR-3CDS	ENST00000340930	ENST00000356711	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
5UTR-3CDS	ENST00000340930	ENST00000251041	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
5UTR-3CDS	ENST00000340930	ENST00000357550	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
5UTR-3CDS	ENST00000340930	ENST00000457511	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
5UTR-intron	ENST00000340930	ENST00000467639	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000519419	ENST00000356711	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000519419	ENST00000251041	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000519419	ENST00000357550	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000519419	ENST00000457511	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-intron	ENST00000519419	ENST00000467639	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000430260	ENST00000356711	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000430260	ENST00000251041	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000430260	ENST00000357550	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000430260	ENST00000457511	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-intron	ENST00000430260	ENST00000467639	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
5UTR-3CDS	ENST00000519881	ENST00000356711	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
5UTR-3CDS	ENST00000519881	ENST00000251041	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
5UTR-3CDS	ENST00000519881	ENST00000357550	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
5UTR-3CDS	ENST00000519881	ENST00000457511	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
5UTR-intron	ENST00000519881	ENST00000467639	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000520892	ENST00000356711	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000520892	ENST00000251041	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000520892	ENST00000357550	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000520892	ENST00000457511	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-intron	ENST00000520892	ENST00000467639	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000519635	ENST00000356711	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000519635	ENST00000251041	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000519635	ENST00000357550	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000519635	ENST00000457511	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-intron	ENST00000519635	ENST00000467639	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000517712	ENST00000356711	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000517712	ENST00000251041	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000517712	ENST00000357550	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000517712	ENST00000457511	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-intron	ENST00000517712	ENST00000467639	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000522950	ENST00000356711	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000522950	ENST00000251041	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000522950	ENST00000357550	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000522950	ENST00000457511	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-intron	ENST00000522950	ENST00000467639	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000520151	ENST00000356711	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000520151	ENST00000251041	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000520151	ENST00000357550	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-3CDS	ENST00000520151	ENST00000457511	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+
intron-intron	ENST00000520151	ENST00000467639	PTK2	chr8	142011224	-	MYO16	chr13	109699264	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for PTK2-MYO16

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
PTK2	chr8	141993940	-	MYO16	chr13	109699263	+	0.99242496	0.007574985
PTK2	chr8	142011223	-	MYO16	chr13	109699263	+	0.000335022	0.999665
PTK2	chr8	141993940	-	MYO16	chr13	109699263	+	0.99242496	0.007574985
PTK2	chr8	142011223	-	MYO16	chr13	109699263	+	0.000335022	0.999665

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PTK2-MYO16

Go to
FGviewer for the breakpoints of :-:
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	MYO16 Q9Y6X6
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for PTK2-MYO16

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for PTK2-MYO16

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for PTK2-MYO16

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for PTK2-MYO16

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	PTK2	C0004238	Atrial Fibrillation	2	CTD_human
Hgene	PTK2	C0007137	Squamous cell carcinoma	2	CTD_human
Hgene	PTK2	C0027626	Neoplasm Invasiveness	2	CTD_human
Hgene	PTK2	C0235480	Paroxysmal atrial fibrillation	2	CTD_human
Hgene	PTK2	C2585653	Persistent atrial fibrillation	2	CTD_human
Hgene	PTK2	C3468561	familial atrial fibrillation	2	CTD_human
Hgene	PTK2	C0003873	Rheumatoid Arthritis	1	CTD_human
Hgene	PTK2	C0007621	Neoplastic Cell Transformation	1	CTD_human
Hgene	PTK2	C0017636	Glioblastoma	1	CTD_human
Hgene	PTK2	C0024668	Mammary Neoplasms, Experimental	1	CTD_human
Hgene	PTK2	C0026640	Mouth Neoplasms	1	CTD_human
Hgene	PTK2	C0153381	Malignant neoplasm of mouth	1	CTD_human
Hgene	PTK2	C0334588	Giant Cell Glioblastoma	1	CTD_human
Hgene	PTK2	C1621958	Glioblastoma Multiforme	1	CTD_human;UNIPROT
Hgene	PTK2	C2239176	Liver carcinoma	1	CTD_human
Tgene	MYO16	C0036341	Schizophrenia	1	PSYGENET