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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PTPN2-L3MBTL4 (FusionGDB2 ID:69808)

Fusion Gene Summary for PTPN2-L3MBTL4

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPN2-L3MBTL4
Fusion gene ID: 69808
HgeneTgene
Gene symbol

PTPN2

L3MBTL4

Gene ID

5771

91133

Gene nameprotein tyrosine phosphatase non-receptor type 2L3MBTL histone methyl-lysine binding protein 4
SynonymsPTN2|PTPT|TC-PTP|TCELLPTP|TCPTPHsT1031
Cytomap

18p11.21

18p11.31

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein phosphatase non-receptor type 2T-cell protein tyrosine phosphataselethal(3)malignant brain tumor-like protein 4H-l(3)mbt-like protein 4L3MBTL4, histone methyl-lysine binding protein
Modification date2020032920200313
UniProtAcc.

Q8NA19

Ensembl transtripts involved in fusion geneENST00000327283, ENST00000591115, 
ENST00000353319, ENST00000309660, 
ENST00000589086, ENST00000591497, 
ENST00000400105, ENST00000317931, 
ENST00000284898, ENST00000400104, 
ENST00000535782, ENST00000578677, 
Fusion gene scores* DoF score14 X 10 X 8=112015 X 12 X 6=1080
# samples 1516
** MAII scorelog2(15/1120*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1080*10)=-2.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPN2 [Title/Abstract] AND L3MBTL4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPTPN2(12814202)-L3MBTL4(5969561), # samples:2
Anticipated loss of major functional domain due to fusion event.PTPN2-L3MBTL4 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
PTPN2-L3MBTL4 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
PTPN2-L3MBTL4 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
PTPN2-L3MBTL4 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PTPN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across L3MBTL4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A8NL-01APTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
ChimerDB4ESCATCGA-L5-A8NLPTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
ChimerDB4ESCATCGA-L5-A8NLPTPN2chr18

12814202

-L3MBTL4chr18

5969561

-


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Fusion Gene ORF analysis for PTPN2-L3MBTL4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000327283ENST00000400105PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
Frame-shiftENST00000327283ENST00000317931PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
Frame-shiftENST00000327283ENST00000284898PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000327283ENST00000400104PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000327283ENST00000535782PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000327283ENST00000578677PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
Frame-shiftENST00000591115ENST00000400105PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
Frame-shiftENST00000591115ENST00000317931PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
Frame-shiftENST00000591115ENST00000284898PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000591115ENST00000400104PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000591115ENST00000535782PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000591115ENST00000578677PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
Frame-shiftENST00000353319ENST00000400105PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
Frame-shiftENST00000353319ENST00000317931PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
Frame-shiftENST00000353319ENST00000284898PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000353319ENST00000400104PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000353319ENST00000535782PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000353319ENST00000578677PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
Frame-shiftENST00000309660ENST00000400105PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
Frame-shiftENST00000309660ENST00000317931PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
Frame-shiftENST00000309660ENST00000284898PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000309660ENST00000400104PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000309660ENST00000535782PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000309660ENST00000578677PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
intron-3CDSENST00000589086ENST00000400105PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
intron-3CDSENST00000589086ENST00000317931PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
intron-3CDSENST00000589086ENST00000284898PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
intron-intronENST00000589086ENST00000400104PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
intron-intronENST00000589086ENST00000535782PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
intron-intronENST00000589086ENST00000578677PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
In-frameENST00000591497ENST00000400105PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
In-frameENST00000591497ENST00000317931PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
In-frameENST00000591497ENST00000284898PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000591497ENST00000400104PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000591497ENST00000535782PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000591497ENST00000578677PTPN2chr18

12814202

-L3MBTL4chr18

5969561

-
Frame-shiftENST00000327283ENST00000400105PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
Frame-shiftENST00000327283ENST00000317931PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
Frame-shiftENST00000327283ENST00000284898PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000327283ENST00000400104PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000327283ENST00000535782PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000327283ENST00000578677PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
Frame-shiftENST00000591115ENST00000400105PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
Frame-shiftENST00000591115ENST00000317931PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
Frame-shiftENST00000591115ENST00000284898PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000591115ENST00000400104PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000591115ENST00000535782PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000591115ENST00000578677PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
Frame-shiftENST00000353319ENST00000400105PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
Frame-shiftENST00000353319ENST00000317931PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
Frame-shiftENST00000353319ENST00000284898PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000353319ENST00000400104PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000353319ENST00000535782PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000353319ENST00000578677PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
Frame-shiftENST00000309660ENST00000400105PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
Frame-shiftENST00000309660ENST00000317931PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
Frame-shiftENST00000309660ENST00000284898PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000309660ENST00000400104PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000309660ENST00000535782PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000309660ENST00000578677PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
intron-3CDSENST00000589086ENST00000400105PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
intron-3CDSENST00000589086ENST00000317931PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
intron-3CDSENST00000589086ENST00000284898PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
intron-intronENST00000589086ENST00000400104PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
intron-intronENST00000589086ENST00000535782PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
intron-intronENST00000589086ENST00000578677PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
In-frameENST00000591497ENST00000400105PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
In-frameENST00000591497ENST00000317931PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
In-frameENST00000591497ENST00000284898PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000591497ENST00000400104PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000591497ENST00000535782PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-
5CDS-intronENST00000591497ENST00000578677PTPN2chr18

12814201

-L3MBTL4chr18

5969561

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000591497PTPN2chr1812814202-ENST00000400105L3MBTL4chr185969561-293910242531287344
ENST00000591497PTPN2chr1812814202-ENST00000317931L3MBTL4chr185969561-293910242531287344
ENST00000591497PTPN2chr1812814202-ENST00000284898L3MBTL4chr185969561-293810242531287344
ENST00000591497PTPN2chr1812814201-ENST00000400105L3MBTL4chr185969561-293910242531287344
ENST00000591497PTPN2chr1812814201-ENST00000317931L3MBTL4chr185969561-293910242531287344
ENST00000591497PTPN2chr1812814201-ENST00000284898L3MBTL4chr185969561-293810242531287344

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000591497ENST00000400105PTPN2chr1812814202-L3MBTL4chr185969561-0.0049530760.995047
ENST00000591497ENST00000317931PTPN2chr1812814202-L3MBTL4chr185969561-0.0049530760.995047
ENST00000591497ENST00000284898PTPN2chr1812814202-L3MBTL4chr185969561-0.0049718790.9950281
ENST00000591497ENST00000400105PTPN2chr1812814201-L3MBTL4chr185969561-0.0049530760.995047
ENST00000591497ENST00000317931PTPN2chr1812814201-L3MBTL4chr185969561-0.0049530760.995047
ENST00000591497ENST00000284898PTPN2chr1812814201-L3MBTL4chr185969561-0.0049718790.9950281

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Fusion Genomic Features for PTPN2-L3MBTL4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PTPN2-L3MBTL4


check button Go to

FGviewer for the breakpoints of chr18:12814202-chr18:5969561

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.L3MBTL4

Q8NA19

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPN2chr18:12814201chr18:5969561ENST00000309660-795_275286.0416.0DomainTyrosine-protein phosphatase
HgenePTPN2chr18:12814201chr18:5969561ENST00000327283-7105_275286.0388.0DomainTyrosine-protein phosphatase
HgenePTPN2chr18:12814201chr18:5969561ENST00000353319-795_275286.0354.0DomainTyrosine-protein phosphatase
HgenePTPN2chr18:12814202chr18:5969561ENST00000309660-795_275286.0416.0DomainTyrosine-protein phosphatase
HgenePTPN2chr18:12814202chr18:5969561ENST00000327283-7105_275286.0388.0DomainTyrosine-protein phosphatase
HgenePTPN2chr18:12814202chr18:5969561ENST00000353319-795_275286.0354.0DomainTyrosine-protein phosphatase
HgenePTPN2chr18:12814201chr18:5969561ENST00000309660-79216_222286.0416.0RegionSubstrate binding
HgenePTPN2chr18:12814201chr18:5969561ENST00000327283-710216_222286.0388.0RegionSubstrate binding
HgenePTPN2chr18:12814201chr18:5969561ENST00000353319-79216_222286.0354.0RegionSubstrate binding
HgenePTPN2chr18:12814202chr18:5969561ENST00000309660-79216_222286.0416.0RegionSubstrate binding
HgenePTPN2chr18:12814202chr18:5969561ENST00000327283-710216_222286.0388.0RegionSubstrate binding
HgenePTPN2chr18:12814202chr18:5969561ENST00000353319-79216_222286.0354.0RegionSubstrate binding
TgeneL3MBTL4chr18:12814201chr18:5969561ENST000002848981620543_607490.3333333333333624.0DomainSAM
TgeneL3MBTL4chr18:12814201chr18:5969561ENST00000400104017543_6070535.0DomainSAM
TgeneL3MBTL4chr18:12814201chr18:5969561ENST000004001051620543_607490.3333333333333624.0DomainSAM
TgeneL3MBTL4chr18:12814202chr18:5969561ENST000002848981620543_607490.3333333333333624.0DomainSAM
TgeneL3MBTL4chr18:12814202chr18:5969561ENST00000400104017543_6070535.0DomainSAM
TgeneL3MBTL4chr18:12814202chr18:5969561ENST000004001051620543_607490.3333333333333624.0DomainSAM
TgeneL3MBTL4chr18:12814201chr18:5969561ENST00000400104017160_2600535.0RepeatNote=MBT 2
TgeneL3MBTL4chr18:12814201chr18:5969561ENST00000400104017269_3640535.0RepeatNote=MBT 3
TgeneL3MBTL4chr18:12814201chr18:5969561ENST0000040010401752_1520535.0RepeatNote=MBT 1
TgeneL3MBTL4chr18:12814202chr18:5969561ENST00000400104017160_2600535.0RepeatNote=MBT 2
TgeneL3MBTL4chr18:12814202chr18:5969561ENST00000400104017269_3640535.0RepeatNote=MBT 3
TgeneL3MBTL4chr18:12814202chr18:5969561ENST0000040010401752_1520535.0RepeatNote=MBT 1
TgeneL3MBTL4chr18:12814201chr18:5969561ENST00000400104017370_4140535.0Zinc fingerCCHHC-type
TgeneL3MBTL4chr18:12814202chr18:5969561ENST00000400104017370_4140535.0Zinc fingerCCHHC-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPN2chr18:12814201chr18:5969561ENST00000309660-79346_415286.0416.0RegionNote=Endoplasmic reticulum location
HgenePTPN2chr18:12814201chr18:5969561ENST00000327283-710346_415286.0388.0RegionNote=Endoplasmic reticulum location
HgenePTPN2chr18:12814201chr18:5969561ENST00000353319-79346_415286.0354.0RegionNote=Endoplasmic reticulum location
HgenePTPN2chr18:12814202chr18:5969561ENST00000309660-79346_415286.0416.0RegionNote=Endoplasmic reticulum location
HgenePTPN2chr18:12814202chr18:5969561ENST00000327283-710346_415286.0388.0RegionNote=Endoplasmic reticulum location
HgenePTPN2chr18:12814202chr18:5969561ENST00000353319-79346_415286.0354.0RegionNote=Endoplasmic reticulum location
TgeneL3MBTL4chr18:12814201chr18:5969561ENST000002848981620160_260490.3333333333333624.0RepeatNote=MBT 2
TgeneL3MBTL4chr18:12814201chr18:5969561ENST000002848981620269_364490.3333333333333624.0RepeatNote=MBT 3
TgeneL3MBTL4chr18:12814201chr18:5969561ENST00000284898162052_152490.3333333333333624.0RepeatNote=MBT 1
TgeneL3MBTL4chr18:12814201chr18:5969561ENST000004001051620160_260490.3333333333333624.0RepeatNote=MBT 2
TgeneL3MBTL4chr18:12814201chr18:5969561ENST000004001051620269_364490.3333333333333624.0RepeatNote=MBT 3
TgeneL3MBTL4chr18:12814201chr18:5969561ENST00000400105162052_152490.3333333333333624.0RepeatNote=MBT 1
TgeneL3MBTL4chr18:12814202chr18:5969561ENST000002848981620160_260490.3333333333333624.0RepeatNote=MBT 2
TgeneL3MBTL4chr18:12814202chr18:5969561ENST000002848981620269_364490.3333333333333624.0RepeatNote=MBT 3
TgeneL3MBTL4chr18:12814202chr18:5969561ENST00000284898162052_152490.3333333333333624.0RepeatNote=MBT 1
TgeneL3MBTL4chr18:12814202chr18:5969561ENST000004001051620160_260490.3333333333333624.0RepeatNote=MBT 2
TgeneL3MBTL4chr18:12814202chr18:5969561ENST000004001051620269_364490.3333333333333624.0RepeatNote=MBT 3
TgeneL3MBTL4chr18:12814202chr18:5969561ENST00000400105162052_152490.3333333333333624.0RepeatNote=MBT 1
TgeneL3MBTL4chr18:12814201chr18:5969561ENST000002848981620370_414490.3333333333333624.0Zinc fingerCCHHC-type
TgeneL3MBTL4chr18:12814201chr18:5969561ENST000004001051620370_414490.3333333333333624.0Zinc fingerCCHHC-type
TgeneL3MBTL4chr18:12814202chr18:5969561ENST000002848981620370_414490.3333333333333624.0Zinc fingerCCHHC-type
TgeneL3MBTL4chr18:12814202chr18:5969561ENST000004001051620370_414490.3333333333333624.0Zinc fingerCCHHC-type


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Fusion Gene Sequence for PTPN2-L3MBTL4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000591497_ENST00000400105_TCGA-L5-A8NL-01A_PTPN2_chr18_12814202_-_L3MBTL4_chr18_5969561_length(transcript)=2939nt_BP=1024nt
AGATCGGTGGTTAGGGGTGGAATGGGGAAGAGTGTGCCTGCCAAGGGGCACACAGAACCTTTGTGCTGATGGAATAGTATTCAATGCAGG
GAACAGACCAGTTCATCATGGAGGCATTCCATCAGAGCGTCTAGTTAGAGAAGATATGTCATGGACTGCATCGGCACAGAAGTGGGGTTT
ATGTGAGAGAGGAGTTGGAAGTCACACCTGAGTGGAGAGCAACGTGAAAAGGTGATGTCAGCAAGAATTTAGGATGTATGGAAAGGATGG
TAAAGGCACCAACTGGATGGATCAGGGAGACATGGAATGCAGAATGCAGGAAATAGATGATCACAGTCGTGTTAAACTGCAAAATGCTGA
GAATGATTATATTAATGCCAGTTTAGTTGACATAGAAGAGGCACAAAGGAGTTACATCTTAACACAGGGTCCACTTCCTAACACATGCTG
CCATTTCTGGCTTATGGTTTGGCAGCAGAAGACCAAAGCAGTTGTCATGCTGAACCGCATTGTGGAGAAAGAATCGGTTAAATGTGCACA
GTACTGGCCAACAGATGACCAAGAGATGCTGTTTAAAGAAACAGGATTCAGTGTGAAGCTCTTGTCAGAAGATGTGAAGTCGTATTATAC
AGTACATCTACTACAATTAGAAAATATCAATAGTGGTGAAACCAGAACAATATCTCACTTTCATTATACTACCTGGCCAGATTTTGGAGT
CCCTGAATCACCAGCTTCATTTCTCAATTTCTTGTTTAAAGTGAGAGAATCTGGCTCCTTGAACCCTGACCATGGGCCTGCGGTGATCCA
CTGTAGTGCAGGCATTGGGCGCTCTGGCACCTTCTCTCTGGTAGACACTTGTCTTGTTTTGATGGAAAAAGGAGATGATATTAACATAAA
ACAAGTGTTACTGAACATGAGAAAATACCGAATGGGTCTTATTCAGACCCCAGATCAACTGAGATTCTCATACATGGCTATAATAGAAGG
AGCAAAATGTATAAAGGGAGATTCTAGTATACAGAATACTCGGTGGAGCAGGCGCAGCAGGTGCTTCACCAGTCAGTGTCCATGTCCACG
GTGTCAGCCCACCCTTTTCGGGACCTTCCCCTCGGCAGGGAGCAACACTGCAAGTTGCTTCCAGGCGTGGCTGACATCCGGGCCAGCCAA
GTGGCACGTTGGACTGTGGATGAGGTGGCTGAGTTTGTACAGTCTCTTCTGGGCTGTGAAGAGCATGCCAAGTGCTTTAAGAAAGAGCAG
ATCGATGGCAAAGCCTTCCTGCTTCTGACACAGACGGACATTGTCAAAGTGATGAAGATCAAACTGGGCCCAGCACTGAAGATTTACAAC
TCTATCCTGATGTTCAGGCATTCCCAGGAACTCCCTGAAGAAGATATTGCCTCAGGCCAAGAAGTCAGGGGATGAATGGGCTCCCTGAAC
TTCCTCTGGCACCAAGACCTGCGCTCTTTCAGCAATAAAAGTGGAGCACATTAATTTGATGTGAATGTCCCCATGGCCGTATCCACACTG
AATCTGGACTTTTTAAAGTGTCTGTGATTTGTTTACATGTTTAGAGGATTTTGATGACTGGTCCAGTGCCAATGACTCAGAGGCTTAGGC
CCATCTGTGGGTTTGGTTTACGAACATTGTTATCTTTGGTGGGATCCGCTCAGCTCTGATTTGTTTGCAAGACAGACCAAAGAAGCCCAC
ACATCCACCTTTATTCTTCTCCGTCACCAGAAAAGAAACCATTTTCCATCTTACAAGCATAACACTCTCAAGTGGTGAAATATTAGAAAA
GCAGTGTTCATGAATACATCGTTAATGTTTTTACCAGAGCAACATCGAGCTTGGCTCAGATCTGCCATGGAGCACAGCTAGTCTAAGAGC
TAGAGGCCTGGTGCTTTCAAAAGACTTCATGTGAGATTTTTGTGTACTTTACTCAGGAAAGTGTGAATCTCTAAAAAATAATAATAATAA
GCACATGTTTTCATGATTCATTAATTCTCCTTTTTGTTCCATTAACCATTTCTTGGTTGTGCTCCCAAGCTTTCCTGGAGCCTCCACAAA
GGAGAGTAGCCAGGAGTAATGAGAGGACGGTCAGGTGGGCACTTCCAAAAGCTGGAGAGACCCTTCTGAGGACCCTCCACCATCAGCGGG
GCCTCAGGGGACCCTGTCCTAACACTGGTGTGGCTGCTGGGCCAGACGCTCACCTGCACAGAACTCCTCCCTGCTCCCACTCTGAAGGGC
GTTTCAGAATTGACTCATTTCCACTGCAGTCTGCCAGAACCCCTGTAATAAGGAGCTGTGTTATATTACATCTGGGGCTGTGTGCATCTT
TACAAATGGAGACACACTATTCAAAGGGAAGATCTCTAAAGTAGGGAGCGTGGTACTTATTCTTTGTTTGAAACATTCCGATTTGTTGTC
AGGCCTTATTTGTTTTTTGTAAGTGATTGTATCGGAGGCTTAAGTTGTGTGGAATCAGTCCCACAGTGTTGAAAGACAAGTACCTCTTTT
CTGACACTTCTTACTACTTTTACAGGTAGTAACAGCTACAAATACTCTCCCAGAAGTGGAGGGACACCATTTGTGGGTGGGGAGAAAGAG
GGAGAGGTTCTATGTCCACTTGCTTCATTAAGAATGTTAAGGTTTAAGAAAGTTGATTCTGCTTGGAGAATTTCTCAAGCTTTACATTTT
TTTTTCACTGAAGAAAATAAACAAACTCTAAGAGGTGTGCATATATAACATTTCTTTAGATCTTTACCTAAAAGGAATTTTAATATATTA
TTGGTTGATGTAAATTTTGTTTCTGTGGAGTTTTGTTTGTTTTGCTTTTTGTAGACTGCCATGTGCAAGTAAAATTCCTGCTTCTGCCAT

>In-frame_ENST00000591497_ENST00000400105_TCGA-L5-A8NL-01A_PTPN2_chr18_12814202_-_L3MBTL4_chr18_5969561_length(amino acids)=344AA_start in transcript=253_stop in transcript=1287
MYGKDGKGTNWMDQGDMECRMQEIDDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKE
SVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDH
GPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQNTRWSRRSRCFTS

--------------------------------------------------------------
>In-frame_ENST00000591497_ENST00000317931_TCGA-L5-A8NL-01A_PTPN2_chr18_12814202_-_L3MBTL4_chr18_5969561_length(transcript)=2939nt_BP=1024nt
AGATCGGTGGTTAGGGGTGGAATGGGGAAGAGTGTGCCTGCCAAGGGGCACACAGAACCTTTGTGCTGATGGAATAGTATTCAATGCAGG
GAACAGACCAGTTCATCATGGAGGCATTCCATCAGAGCGTCTAGTTAGAGAAGATATGTCATGGACTGCATCGGCACAGAAGTGGGGTTT
ATGTGAGAGAGGAGTTGGAAGTCACACCTGAGTGGAGAGCAACGTGAAAAGGTGATGTCAGCAAGAATTTAGGATGTATGGAAAGGATGG
TAAAGGCACCAACTGGATGGATCAGGGAGACATGGAATGCAGAATGCAGGAAATAGATGATCACAGTCGTGTTAAACTGCAAAATGCTGA
GAATGATTATATTAATGCCAGTTTAGTTGACATAGAAGAGGCACAAAGGAGTTACATCTTAACACAGGGTCCACTTCCTAACACATGCTG
CCATTTCTGGCTTATGGTTTGGCAGCAGAAGACCAAAGCAGTTGTCATGCTGAACCGCATTGTGGAGAAAGAATCGGTTAAATGTGCACA
GTACTGGCCAACAGATGACCAAGAGATGCTGTTTAAAGAAACAGGATTCAGTGTGAAGCTCTTGTCAGAAGATGTGAAGTCGTATTATAC
AGTACATCTACTACAATTAGAAAATATCAATAGTGGTGAAACCAGAACAATATCTCACTTTCATTATACTACCTGGCCAGATTTTGGAGT
CCCTGAATCACCAGCTTCATTTCTCAATTTCTTGTTTAAAGTGAGAGAATCTGGCTCCTTGAACCCTGACCATGGGCCTGCGGTGATCCA
CTGTAGTGCAGGCATTGGGCGCTCTGGCACCTTCTCTCTGGTAGACACTTGTCTTGTTTTGATGGAAAAAGGAGATGATATTAACATAAA
ACAAGTGTTACTGAACATGAGAAAATACCGAATGGGTCTTATTCAGACCCCAGATCAACTGAGATTCTCATACATGGCTATAATAGAAGG
AGCAAAATGTATAAAGGGAGATTCTAGTATACAGAATACTCGGTGGAGCAGGCGCAGCAGGTGCTTCACCAGTCAGTGTCCATGTCCACG
GTGTCAGCCCACCCTTTTCGGGACCTTCCCCTCGGCAGGGAGCAACACTGCAAGTTGCTTCCAGGCGTGGCTGACATCCGGGCCAGCCAA
GTGGCACGTTGGACTGTGGATGAGGTGGCTGAGTTTGTACAGTCTCTTCTGGGCTGTGAAGAGCATGCCAAGTGCTTTAAGAAAGAGCAG
ATCGATGGCAAAGCCTTCCTGCTTCTGACACAGACGGACATTGTCAAAGTGATGAAGATCAAACTGGGCCCAGCACTGAAGATTTACAAC
TCTATCCTGATGTTCAGGCATTCCCAGGAACTCCCTGAAGAAGATATTGCCTCAGGCCAAGAAGTCAGGGGATGAATGGGCTCCCTGAAC
TTCCTCTGGCACCAAGACCTGCGCTCTTTCAGCAATAAAAGTGGAGCACATTAATTTGATGTGAATGTCCCCATGGCCGTATCCACACTG
AATCTGGACTTTTTAAAGTGTCTGTGATTTGTTTACATGTTTAGAGGATTTTGATGACTGGTCCAGTGCCAATGACTCAGAGGCTTAGGC
CCATCTGTGGGTTTGGTTTACGAACATTGTTATCTTTGGTGGGATCCGCTCAGCTCTGATTTGTTTGCAAGACAGACCAAAGAAGCCCAC
ACATCCACCTTTATTCTTCTCCGTCACCAGAAAAGAAACCATTTTCCATCTTACAAGCATAACACTCTCAAGTGGTGAAATATTAGAAAA
GCAGTGTTCATGAATACATCGTTAATGTTTTTACCAGAGCAACATCGAGCTTGGCTCAGATCTGCCATGGAGCACAGCTAGTCTAAGAGC
TAGAGGCCTGGTGCTTTCAAAAGACTTCATGTGAGATTTTTGTGTACTTTACTCAGGAAAGTGTGAATCTCTAAAAAATAATAATAATAA
GCACATGTTTTCATGATTCATTAATTCTCCTTTTTGTTCCATTAACCATTTCTTGGTTGTGCTCCCAAGCTTTCCTGGAGCCTCCACAAA
GGAGAGTAGCCAGGAGTAATGAGAGGACGGTCAGGTGGGCACTTCCAAAAGCTGGAGAGACCCTTCTGAGGACCCTCCACCATCAGCGGG
GCCTCAGGGGACCCTGTCCTAACACTGGTGTGGCTGCTGGGCCAGACGCTCACCTGCACAGAACTCCTCCCTGCTCCCACTCTGAAGGGC
GTTTCAGAATTGACTCATTTCCACTGCAGTCTGCCAGAACCCCTGTAATAAGGAGCTGTGTTATATTACATCTGGGGCTGTGTGCATCTT
TACAAATGGAGACACACTATTCAAAGGGAAGATCTCTAAAGTAGGGAGCGTGGTACTTATTCTTTGTTTGAAACATTCCGATTTGTTGTC
AGGCCTTATTTGTTTTTTGTAAGTGATTGTATCGGAGGCTTAAGTTGTGTGGAATCAGTCCCACAGTGTTGAAAGACAAGTACCTCTTTT
CTGACACTTCTTACTACTTTTACAGGTAGTAACAGCTACAAATACTCTCCCAGAAGTGGAGGGACACCATTTGTGGGTGGGGAGAAAGAG
GGAGAGGTTCTATGTCCACTTGCTTCATTAAGAATGTTAAGGTTTAAGAAAGTTGATTCTGCTTGGAGAATTTCTCAAGCTTTACATTTT
TTTTTCACTGAAGAAAATAAACAAACTCTAAGAGGTGTGCATATATAACATTTCTTTAGATCTTTACCTAAAAGGAATTTTAATATATTA
TTGGTTGATGTAAATTTTGTTTCTGTGGAGTTTTGTTTGTTTTGCTTTTTGTAGACTGCCATGTGCAAGTAAAATTCCTGCTTCTGCCAT

>In-frame_ENST00000591497_ENST00000317931_TCGA-L5-A8NL-01A_PTPN2_chr18_12814202_-_L3MBTL4_chr18_5969561_length(amino acids)=344AA_start in transcript=253_stop in transcript=1287
MYGKDGKGTNWMDQGDMECRMQEIDDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKE
SVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDH
GPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQNTRWSRRSRCFTS

--------------------------------------------------------------
>In-frame_ENST00000591497_ENST00000284898_TCGA-L5-A8NL-01A_PTPN2_chr18_12814202_-_L3MBTL4_chr18_5969561_length(transcript)=2938nt_BP=1024nt
AGATCGGTGGTTAGGGGTGGAATGGGGAAGAGTGTGCCTGCCAAGGGGCACACAGAACCTTTGTGCTGATGGAATAGTATTCAATGCAGG
GAACAGACCAGTTCATCATGGAGGCATTCCATCAGAGCGTCTAGTTAGAGAAGATATGTCATGGACTGCATCGGCACAGAAGTGGGGTTT
ATGTGAGAGAGGAGTTGGAAGTCACACCTGAGTGGAGAGCAACGTGAAAAGGTGATGTCAGCAAGAATTTAGGATGTATGGAAAGGATGG
TAAAGGCACCAACTGGATGGATCAGGGAGACATGGAATGCAGAATGCAGGAAATAGATGATCACAGTCGTGTTAAACTGCAAAATGCTGA
GAATGATTATATTAATGCCAGTTTAGTTGACATAGAAGAGGCACAAAGGAGTTACATCTTAACACAGGGTCCACTTCCTAACACATGCTG
CCATTTCTGGCTTATGGTTTGGCAGCAGAAGACCAAAGCAGTTGTCATGCTGAACCGCATTGTGGAGAAAGAATCGGTTAAATGTGCACA
GTACTGGCCAACAGATGACCAAGAGATGCTGTTTAAAGAAACAGGATTCAGTGTGAAGCTCTTGTCAGAAGATGTGAAGTCGTATTATAC
AGTACATCTACTACAATTAGAAAATATCAATAGTGGTGAAACCAGAACAATATCTCACTTTCATTATACTACCTGGCCAGATTTTGGAGT
CCCTGAATCACCAGCTTCATTTCTCAATTTCTTGTTTAAAGTGAGAGAATCTGGCTCCTTGAACCCTGACCATGGGCCTGCGGTGATCCA
CTGTAGTGCAGGCATTGGGCGCTCTGGCACCTTCTCTCTGGTAGACACTTGTCTTGTTTTGATGGAAAAAGGAGATGATATTAACATAAA
ACAAGTGTTACTGAACATGAGAAAATACCGAATGGGTCTTATTCAGACCCCAGATCAACTGAGATTCTCATACATGGCTATAATAGAAGG
AGCAAAATGTATAAAGGGAGATTCTAGTATACAGAATACTCGGTGGAGCAGGCGCAGCAGGTGCTTCACCAGTCAGTGTCCATGTCCACG
GTGTCAGCCCACCCTTTTCGGGACCTTCCCCTCGGCAGGGAGCAACACTGCAAGTTGCTTCCAGGCGTGGCTGACATCCGGGCCAGCCAA
GTGGCACGTTGGACTGTGGATGAGGTGGCTGAGTTTGTACAGTCTCTTCTGGGCTGTGAAGAGCATGCCAAGTGCTTTAAGAAAGAGCAG
ATCGATGGCAAAGCCTTCCTGCTTCTGACACAGACGGACATTGTCAAAGTGATGAAGATCAAACTGGGCCCAGCACTGAAGATTTACAAC
TCTATCCTGATGTTCAGGCATTCCCAGGAACTCCCTGAAGAAGATATTGCCTCAGGCCAAGAAGTCAGGGGATGAATGGGCTCCCTGAAC
TTCCTCTGGCACCAAGACCTGCGCTCTTTCAGCAATAAAAGTGGAGCACATTAATTTGATGTGAATGTCCCCATGGCCGTATCCACACTG
AATCTGGACTTTTTAAAGTGTCTGTGATTTGTTTACATGTTTAGAGGATTTTGATGACTGGTCCAGTGCCAATGACTCAGAGGCTTAGGC
CCATCTGTGGGTTTGGTTTACGAACATTGTTATCTTTGGTGGGATCCGCTCAGCTCTGATTTGTTTGCAAGACAGACCAAAGAAGCCCAC
ACATCCACCTTTATTCTTCTCCGTCACCAGAAAAGAAACCATTTTCCATCTTACAAGCATAACACTCTCAAGTGGTGAAATATTAGAAAA
GCAGTGTTCATGAATACATCGTTAATGTTTTTACCAGAGCAACATCGAGCTTGGCTCAGATCTGCCATGGAGCACAGCTAGTCTAAGAGC
TAGAGGCCTGGTGCTTTCAAAAGACTTCATGTGAGATTTTTGTGTACTTTACTCAGGAAAGTGTGAATCTCTAAAAAATAATAATAATAA
GCACATGTTTTCATGATTCATTAATTCTCCTTTTTGTTCCATTAACCATTTCTTGGTTGTGCTCCCAAGCTTTCCTGGAGCCTCCACAAA
GGAGAGTAGCCAGGAGTAATGAGAGGACGGTCAGGTGGGCACTTCCAAAAGCTGGAGAGACCCTTCTGAGGACCCTCCACCATCAGCGGG
GCCTCAGGGGACCCTGTCCTAACACTGGTGTGGCTGCTGGGCCAGACGCTCACCTGCACAGAACTCCTCCCTGCTCCCACTCTGAAGGGC
GTTTCAGAATTGACTCATTTCCACTGCAGTCTGCCAGAACCCCTGTAATAAGGAGCTGTGTTATATTACATCTGGGGCTGTGTGCATCTT
TACAAATGGAGACACACTATTCAAAGGGAAGATCTCTAAAGTAGGGAGCGTGGTACTTATTCTTTGTTTGAAACATTCCGATTTGTTGTC
AGGCCTTATTTGTTTTTTGTAAGTGATTGTATCGGAGGCTTAAGTTGTGTGGAATCAGTCCCACAGTGTTGAAAGACAAGTACCTCTTTT
CTGACACTTCTTACTACTTTTACAGGTAGTAACAGCTACAAATACTCTCCCAGAAGTGGAGGGACACCATTTGTGGGTGGGGAGAAAGAG
GGAGAGGTTCTATGTCCACTTGCTTCATTAAGAATGTTAAGGTTTAAGAAAGTTGATTCTGCTTGGAGAATTTCTCAAGCTTTACATTTT
TTTTTCACTGAAGAAAATAAACAAACTCTAAGAGGTGTGCATATATAACATTTCTTTAGATCTTTACCTAAAAGGAATTTTAATATATTA
TTGGTTGATGTAAATTTTGTTTCTGTGGAGTTTTGTTTGTTTTGCTTTTTGTAGACTGCCATGTGCAAGTAAAATTCCTGCTTCTGCCAT

>In-frame_ENST00000591497_ENST00000284898_TCGA-L5-A8NL-01A_PTPN2_chr18_12814202_-_L3MBTL4_chr18_5969561_length(amino acids)=344AA_start in transcript=253_stop in transcript=1287
MYGKDGKGTNWMDQGDMECRMQEIDDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKE
SVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDH
GPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQNTRWSRRSRCFTS

--------------------------------------------------------------
>In-frame_ENST00000591497_ENST00000400105_TCGA-L5-A8NL_PTPN2_chr18_12814201_-_L3MBTL4_chr18_5969561_length(transcript)=2939nt_BP=1024nt
AGATCGGTGGTTAGGGGTGGAATGGGGAAGAGTGTGCCTGCCAAGGGGCACACAGAACCTTTGTGCTGATGGAATAGTATTCAATGCAGG
GAACAGACCAGTTCATCATGGAGGCATTCCATCAGAGCGTCTAGTTAGAGAAGATATGTCATGGACTGCATCGGCACAGAAGTGGGGTTT
ATGTGAGAGAGGAGTTGGAAGTCACACCTGAGTGGAGAGCAACGTGAAAAGGTGATGTCAGCAAGAATTTAGGATGTATGGAAAGGATGG
TAAAGGCACCAACTGGATGGATCAGGGAGACATGGAATGCAGAATGCAGGAAATAGATGATCACAGTCGTGTTAAACTGCAAAATGCTGA
GAATGATTATATTAATGCCAGTTTAGTTGACATAGAAGAGGCACAAAGGAGTTACATCTTAACACAGGGTCCACTTCCTAACACATGCTG
CCATTTCTGGCTTATGGTTTGGCAGCAGAAGACCAAAGCAGTTGTCATGCTGAACCGCATTGTGGAGAAAGAATCGGTTAAATGTGCACA
GTACTGGCCAACAGATGACCAAGAGATGCTGTTTAAAGAAACAGGATTCAGTGTGAAGCTCTTGTCAGAAGATGTGAAGTCGTATTATAC
AGTACATCTACTACAATTAGAAAATATCAATAGTGGTGAAACCAGAACAATATCTCACTTTCATTATACTACCTGGCCAGATTTTGGAGT
CCCTGAATCACCAGCTTCATTTCTCAATTTCTTGTTTAAAGTGAGAGAATCTGGCTCCTTGAACCCTGACCATGGGCCTGCGGTGATCCA
CTGTAGTGCAGGCATTGGGCGCTCTGGCACCTTCTCTCTGGTAGACACTTGTCTTGTTTTGATGGAAAAAGGAGATGATATTAACATAAA
ACAAGTGTTACTGAACATGAGAAAATACCGAATGGGTCTTATTCAGACCCCAGATCAACTGAGATTCTCATACATGGCTATAATAGAAGG
AGCAAAATGTATAAAGGGAGATTCTAGTATACAGAATACTCGGTGGAGCAGGCGCAGCAGGTGCTTCACCAGTCAGTGTCCATGTCCACG
GTGTCAGCCCACCCTTTTCGGGACCTTCCCCTCGGCAGGGAGCAACACTGCAAGTTGCTTCCAGGCGTGGCTGACATCCGGGCCAGCCAA
GTGGCACGTTGGACTGTGGATGAGGTGGCTGAGTTTGTACAGTCTCTTCTGGGCTGTGAAGAGCATGCCAAGTGCTTTAAGAAAGAGCAG
ATCGATGGCAAAGCCTTCCTGCTTCTGACACAGACGGACATTGTCAAAGTGATGAAGATCAAACTGGGCCCAGCACTGAAGATTTACAAC
TCTATCCTGATGTTCAGGCATTCCCAGGAACTCCCTGAAGAAGATATTGCCTCAGGCCAAGAAGTCAGGGGATGAATGGGCTCCCTGAAC
TTCCTCTGGCACCAAGACCTGCGCTCTTTCAGCAATAAAAGTGGAGCACATTAATTTGATGTGAATGTCCCCATGGCCGTATCCACACTG
AATCTGGACTTTTTAAAGTGTCTGTGATTTGTTTACATGTTTAGAGGATTTTGATGACTGGTCCAGTGCCAATGACTCAGAGGCTTAGGC
CCATCTGTGGGTTTGGTTTACGAACATTGTTATCTTTGGTGGGATCCGCTCAGCTCTGATTTGTTTGCAAGACAGACCAAAGAAGCCCAC
ACATCCACCTTTATTCTTCTCCGTCACCAGAAAAGAAACCATTTTCCATCTTACAAGCATAACACTCTCAAGTGGTGAAATATTAGAAAA
GCAGTGTTCATGAATACATCGTTAATGTTTTTACCAGAGCAACATCGAGCTTGGCTCAGATCTGCCATGGAGCACAGCTAGTCTAAGAGC
TAGAGGCCTGGTGCTTTCAAAAGACTTCATGTGAGATTTTTGTGTACTTTACTCAGGAAAGTGTGAATCTCTAAAAAATAATAATAATAA
GCACATGTTTTCATGATTCATTAATTCTCCTTTTTGTTCCATTAACCATTTCTTGGTTGTGCTCCCAAGCTTTCCTGGAGCCTCCACAAA
GGAGAGTAGCCAGGAGTAATGAGAGGACGGTCAGGTGGGCACTTCCAAAAGCTGGAGAGACCCTTCTGAGGACCCTCCACCATCAGCGGG
GCCTCAGGGGACCCTGTCCTAACACTGGTGTGGCTGCTGGGCCAGACGCTCACCTGCACAGAACTCCTCCCTGCTCCCACTCTGAAGGGC
GTTTCAGAATTGACTCATTTCCACTGCAGTCTGCCAGAACCCCTGTAATAAGGAGCTGTGTTATATTACATCTGGGGCTGTGTGCATCTT
TACAAATGGAGACACACTATTCAAAGGGAAGATCTCTAAAGTAGGGAGCGTGGTACTTATTCTTTGTTTGAAACATTCCGATTTGTTGTC
AGGCCTTATTTGTTTTTTGTAAGTGATTGTATCGGAGGCTTAAGTTGTGTGGAATCAGTCCCACAGTGTTGAAAGACAAGTACCTCTTTT
CTGACACTTCTTACTACTTTTACAGGTAGTAACAGCTACAAATACTCTCCCAGAAGTGGAGGGACACCATTTGTGGGTGGGGAGAAAGAG
GGAGAGGTTCTATGTCCACTTGCTTCATTAAGAATGTTAAGGTTTAAGAAAGTTGATTCTGCTTGGAGAATTTCTCAAGCTTTACATTTT
TTTTTCACTGAAGAAAATAAACAAACTCTAAGAGGTGTGCATATATAACATTTCTTTAGATCTTTACCTAAAAGGAATTTTAATATATTA
TTGGTTGATGTAAATTTTGTTTCTGTGGAGTTTTGTTTGTTTTGCTTTTTGTAGACTGCCATGTGCAAGTAAAATTCCTGCTTCTGCCAT

>In-frame_ENST00000591497_ENST00000400105_TCGA-L5-A8NL_PTPN2_chr18_12814201_-_L3MBTL4_chr18_5969561_length(amino acids)=344AA_start in transcript=253_stop in transcript=1287
MYGKDGKGTNWMDQGDMECRMQEIDDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKE
SVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDH
GPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQNTRWSRRSRCFTS

--------------------------------------------------------------
>In-frame_ENST00000591497_ENST00000317931_TCGA-L5-A8NL_PTPN2_chr18_12814201_-_L3MBTL4_chr18_5969561_length(transcript)=2939nt_BP=1024nt
AGATCGGTGGTTAGGGGTGGAATGGGGAAGAGTGTGCCTGCCAAGGGGCACACAGAACCTTTGTGCTGATGGAATAGTATTCAATGCAGG
GAACAGACCAGTTCATCATGGAGGCATTCCATCAGAGCGTCTAGTTAGAGAAGATATGTCATGGACTGCATCGGCACAGAAGTGGGGTTT
ATGTGAGAGAGGAGTTGGAAGTCACACCTGAGTGGAGAGCAACGTGAAAAGGTGATGTCAGCAAGAATTTAGGATGTATGGAAAGGATGG
TAAAGGCACCAACTGGATGGATCAGGGAGACATGGAATGCAGAATGCAGGAAATAGATGATCACAGTCGTGTTAAACTGCAAAATGCTGA
GAATGATTATATTAATGCCAGTTTAGTTGACATAGAAGAGGCACAAAGGAGTTACATCTTAACACAGGGTCCACTTCCTAACACATGCTG
CCATTTCTGGCTTATGGTTTGGCAGCAGAAGACCAAAGCAGTTGTCATGCTGAACCGCATTGTGGAGAAAGAATCGGTTAAATGTGCACA
GTACTGGCCAACAGATGACCAAGAGATGCTGTTTAAAGAAACAGGATTCAGTGTGAAGCTCTTGTCAGAAGATGTGAAGTCGTATTATAC
AGTACATCTACTACAATTAGAAAATATCAATAGTGGTGAAACCAGAACAATATCTCACTTTCATTATACTACCTGGCCAGATTTTGGAGT
CCCTGAATCACCAGCTTCATTTCTCAATTTCTTGTTTAAAGTGAGAGAATCTGGCTCCTTGAACCCTGACCATGGGCCTGCGGTGATCCA
CTGTAGTGCAGGCATTGGGCGCTCTGGCACCTTCTCTCTGGTAGACACTTGTCTTGTTTTGATGGAAAAAGGAGATGATATTAACATAAA
ACAAGTGTTACTGAACATGAGAAAATACCGAATGGGTCTTATTCAGACCCCAGATCAACTGAGATTCTCATACATGGCTATAATAGAAGG
AGCAAAATGTATAAAGGGAGATTCTAGTATACAGAATACTCGGTGGAGCAGGCGCAGCAGGTGCTTCACCAGTCAGTGTCCATGTCCACG
GTGTCAGCCCACCCTTTTCGGGACCTTCCCCTCGGCAGGGAGCAACACTGCAAGTTGCTTCCAGGCGTGGCTGACATCCGGGCCAGCCAA
GTGGCACGTTGGACTGTGGATGAGGTGGCTGAGTTTGTACAGTCTCTTCTGGGCTGTGAAGAGCATGCCAAGTGCTTTAAGAAAGAGCAG
ATCGATGGCAAAGCCTTCCTGCTTCTGACACAGACGGACATTGTCAAAGTGATGAAGATCAAACTGGGCCCAGCACTGAAGATTTACAAC
TCTATCCTGATGTTCAGGCATTCCCAGGAACTCCCTGAAGAAGATATTGCCTCAGGCCAAGAAGTCAGGGGATGAATGGGCTCCCTGAAC
TTCCTCTGGCACCAAGACCTGCGCTCTTTCAGCAATAAAAGTGGAGCACATTAATTTGATGTGAATGTCCCCATGGCCGTATCCACACTG
AATCTGGACTTTTTAAAGTGTCTGTGATTTGTTTACATGTTTAGAGGATTTTGATGACTGGTCCAGTGCCAATGACTCAGAGGCTTAGGC
CCATCTGTGGGTTTGGTTTACGAACATTGTTATCTTTGGTGGGATCCGCTCAGCTCTGATTTGTTTGCAAGACAGACCAAAGAAGCCCAC
ACATCCACCTTTATTCTTCTCCGTCACCAGAAAAGAAACCATTTTCCATCTTACAAGCATAACACTCTCAAGTGGTGAAATATTAGAAAA
GCAGTGTTCATGAATACATCGTTAATGTTTTTACCAGAGCAACATCGAGCTTGGCTCAGATCTGCCATGGAGCACAGCTAGTCTAAGAGC
TAGAGGCCTGGTGCTTTCAAAAGACTTCATGTGAGATTTTTGTGTACTTTACTCAGGAAAGTGTGAATCTCTAAAAAATAATAATAATAA
GCACATGTTTTCATGATTCATTAATTCTCCTTTTTGTTCCATTAACCATTTCTTGGTTGTGCTCCCAAGCTTTCCTGGAGCCTCCACAAA
GGAGAGTAGCCAGGAGTAATGAGAGGACGGTCAGGTGGGCACTTCCAAAAGCTGGAGAGACCCTTCTGAGGACCCTCCACCATCAGCGGG
GCCTCAGGGGACCCTGTCCTAACACTGGTGTGGCTGCTGGGCCAGACGCTCACCTGCACAGAACTCCTCCCTGCTCCCACTCTGAAGGGC
GTTTCAGAATTGACTCATTTCCACTGCAGTCTGCCAGAACCCCTGTAATAAGGAGCTGTGTTATATTACATCTGGGGCTGTGTGCATCTT
TACAAATGGAGACACACTATTCAAAGGGAAGATCTCTAAAGTAGGGAGCGTGGTACTTATTCTTTGTTTGAAACATTCCGATTTGTTGTC
AGGCCTTATTTGTTTTTTGTAAGTGATTGTATCGGAGGCTTAAGTTGTGTGGAATCAGTCCCACAGTGTTGAAAGACAAGTACCTCTTTT
CTGACACTTCTTACTACTTTTACAGGTAGTAACAGCTACAAATACTCTCCCAGAAGTGGAGGGACACCATTTGTGGGTGGGGAGAAAGAG
GGAGAGGTTCTATGTCCACTTGCTTCATTAAGAATGTTAAGGTTTAAGAAAGTTGATTCTGCTTGGAGAATTTCTCAAGCTTTACATTTT
TTTTTCACTGAAGAAAATAAACAAACTCTAAGAGGTGTGCATATATAACATTTCTTTAGATCTTTACCTAAAAGGAATTTTAATATATTA
TTGGTTGATGTAAATTTTGTTTCTGTGGAGTTTTGTTTGTTTTGCTTTTTGTAGACTGCCATGTGCAAGTAAAATTCCTGCTTCTGCCAT

>In-frame_ENST00000591497_ENST00000317931_TCGA-L5-A8NL_PTPN2_chr18_12814201_-_L3MBTL4_chr18_5969561_length(amino acids)=344AA_start in transcript=253_stop in transcript=1287
MYGKDGKGTNWMDQGDMECRMQEIDDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKE
SVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDH
GPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQNTRWSRRSRCFTS

--------------------------------------------------------------
>In-frame_ENST00000591497_ENST00000284898_TCGA-L5-A8NL_PTPN2_chr18_12814201_-_L3MBTL4_chr18_5969561_length(transcript)=2938nt_BP=1024nt
AGATCGGTGGTTAGGGGTGGAATGGGGAAGAGTGTGCCTGCCAAGGGGCACACAGAACCTTTGTGCTGATGGAATAGTATTCAATGCAGG
GAACAGACCAGTTCATCATGGAGGCATTCCATCAGAGCGTCTAGTTAGAGAAGATATGTCATGGACTGCATCGGCACAGAAGTGGGGTTT
ATGTGAGAGAGGAGTTGGAAGTCACACCTGAGTGGAGAGCAACGTGAAAAGGTGATGTCAGCAAGAATTTAGGATGTATGGAAAGGATGG
TAAAGGCACCAACTGGATGGATCAGGGAGACATGGAATGCAGAATGCAGGAAATAGATGATCACAGTCGTGTTAAACTGCAAAATGCTGA
GAATGATTATATTAATGCCAGTTTAGTTGACATAGAAGAGGCACAAAGGAGTTACATCTTAACACAGGGTCCACTTCCTAACACATGCTG
CCATTTCTGGCTTATGGTTTGGCAGCAGAAGACCAAAGCAGTTGTCATGCTGAACCGCATTGTGGAGAAAGAATCGGTTAAATGTGCACA
GTACTGGCCAACAGATGACCAAGAGATGCTGTTTAAAGAAACAGGATTCAGTGTGAAGCTCTTGTCAGAAGATGTGAAGTCGTATTATAC
AGTACATCTACTACAATTAGAAAATATCAATAGTGGTGAAACCAGAACAATATCTCACTTTCATTATACTACCTGGCCAGATTTTGGAGT
CCCTGAATCACCAGCTTCATTTCTCAATTTCTTGTTTAAAGTGAGAGAATCTGGCTCCTTGAACCCTGACCATGGGCCTGCGGTGATCCA
CTGTAGTGCAGGCATTGGGCGCTCTGGCACCTTCTCTCTGGTAGACACTTGTCTTGTTTTGATGGAAAAAGGAGATGATATTAACATAAA
ACAAGTGTTACTGAACATGAGAAAATACCGAATGGGTCTTATTCAGACCCCAGATCAACTGAGATTCTCATACATGGCTATAATAGAAGG
AGCAAAATGTATAAAGGGAGATTCTAGTATACAGAATACTCGGTGGAGCAGGCGCAGCAGGTGCTTCACCAGTCAGTGTCCATGTCCACG
GTGTCAGCCCACCCTTTTCGGGACCTTCCCCTCGGCAGGGAGCAACACTGCAAGTTGCTTCCAGGCGTGGCTGACATCCGGGCCAGCCAA
GTGGCACGTTGGACTGTGGATGAGGTGGCTGAGTTTGTACAGTCTCTTCTGGGCTGTGAAGAGCATGCCAAGTGCTTTAAGAAAGAGCAG
ATCGATGGCAAAGCCTTCCTGCTTCTGACACAGACGGACATTGTCAAAGTGATGAAGATCAAACTGGGCCCAGCACTGAAGATTTACAAC
TCTATCCTGATGTTCAGGCATTCCCAGGAACTCCCTGAAGAAGATATTGCCTCAGGCCAAGAAGTCAGGGGATGAATGGGCTCCCTGAAC
TTCCTCTGGCACCAAGACCTGCGCTCTTTCAGCAATAAAAGTGGAGCACATTAATTTGATGTGAATGTCCCCATGGCCGTATCCACACTG
AATCTGGACTTTTTAAAGTGTCTGTGATTTGTTTACATGTTTAGAGGATTTTGATGACTGGTCCAGTGCCAATGACTCAGAGGCTTAGGC
CCATCTGTGGGTTTGGTTTACGAACATTGTTATCTTTGGTGGGATCCGCTCAGCTCTGATTTGTTTGCAAGACAGACCAAAGAAGCCCAC
ACATCCACCTTTATTCTTCTCCGTCACCAGAAAAGAAACCATTTTCCATCTTACAAGCATAACACTCTCAAGTGGTGAAATATTAGAAAA
GCAGTGTTCATGAATACATCGTTAATGTTTTTACCAGAGCAACATCGAGCTTGGCTCAGATCTGCCATGGAGCACAGCTAGTCTAAGAGC
TAGAGGCCTGGTGCTTTCAAAAGACTTCATGTGAGATTTTTGTGTACTTTACTCAGGAAAGTGTGAATCTCTAAAAAATAATAATAATAA
GCACATGTTTTCATGATTCATTAATTCTCCTTTTTGTTCCATTAACCATTTCTTGGTTGTGCTCCCAAGCTTTCCTGGAGCCTCCACAAA
GGAGAGTAGCCAGGAGTAATGAGAGGACGGTCAGGTGGGCACTTCCAAAAGCTGGAGAGACCCTTCTGAGGACCCTCCACCATCAGCGGG
GCCTCAGGGGACCCTGTCCTAACACTGGTGTGGCTGCTGGGCCAGACGCTCACCTGCACAGAACTCCTCCCTGCTCCCACTCTGAAGGGC
GTTTCAGAATTGACTCATTTCCACTGCAGTCTGCCAGAACCCCTGTAATAAGGAGCTGTGTTATATTACATCTGGGGCTGTGTGCATCTT
TACAAATGGAGACACACTATTCAAAGGGAAGATCTCTAAAGTAGGGAGCGTGGTACTTATTCTTTGTTTGAAACATTCCGATTTGTTGTC
AGGCCTTATTTGTTTTTTGTAAGTGATTGTATCGGAGGCTTAAGTTGTGTGGAATCAGTCCCACAGTGTTGAAAGACAAGTACCTCTTTT
CTGACACTTCTTACTACTTTTACAGGTAGTAACAGCTACAAATACTCTCCCAGAAGTGGAGGGACACCATTTGTGGGTGGGGAGAAAGAG
GGAGAGGTTCTATGTCCACTTGCTTCATTAAGAATGTTAAGGTTTAAGAAAGTTGATTCTGCTTGGAGAATTTCTCAAGCTTTACATTTT
TTTTTCACTGAAGAAAATAAACAAACTCTAAGAGGTGTGCATATATAACATTTCTTTAGATCTTTACCTAAAAGGAATTTTAATATATTA
TTGGTTGATGTAAATTTTGTTTCTGTGGAGTTTTGTTTGTTTTGCTTTTTGTAGACTGCCATGTGCAAGTAAAATTCCTGCTTCTGCCAT

>In-frame_ENST00000591497_ENST00000284898_TCGA-L5-A8NL_PTPN2_chr18_12814201_-_L3MBTL4_chr18_5969561_length(amino acids)=344AA_start in transcript=253_stop in transcript=1287
MYGKDGKGTNWMDQGDMECRMQEIDDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKE
SVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDH
GPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQNTRWSRRSRCFTS

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Fusion Gene PPI Analysis for PTPN2-L3MBTL4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PTPN2-L3MBTL4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTPN2-L3MBTL4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTPN2C0003873Rheumatoid Arthritis1CTD_human
HgenePTPN2C0009324Ulcerative Colitis1CTD_human;GENOMICS_ENGLAND
HgenePTPN2C0010346Crohn Disease1CTD_human
HgenePTPN2C0023492Leukemia, T-Cell1CTD_human
HgenePTPN2C0156147Crohn's disease of large bowel1CTD_human
HgenePTPN2C0267380Crohn's disease of the ileum1CTD_human
HgenePTPN2C0678202Regional enteritis1CTD_human
HgenePTPN2C0949272IIeocolitis1CTD_human
HgenePTPN2C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
HgenePTPN2C2931171Juvenile pauciarticular chronic arthritis1ORPHANET