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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PTPRF-LEFTY2 (FusionGDB2 ID:69941)

Fusion Gene Summary for PTPRF-LEFTY2

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRF-LEFTY2
Fusion gene ID: 69941
HgeneTgene
Gene symbol

PTPRF

LEFTY2

Gene ID

5792

7044

Gene nameprotein tyrosine phosphatase receptor type Fleft-right determination factor 2
SynonymsBNAH2|LAREBAF|LEFTA|LEFTYA|TGFB4
Cytomap

1p34.2

1q42.12

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase FLCA-homologleukocyte antigen-related (LAR) PTP receptorleukocyte antigen-related tyrosine phosphataseleukocyte common antigen relatedprotein tyrosine phosphatase, receptor type, F polypeptidereceptor-linkeleft-right determination factor 2TGF-beta-4endometrial bleeding-associated factorleft-right determination factor Aprotein lefty-2protein lefty-Atransforming growth factor beta-4
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000359947, ENST00000438120, 
ENST00000372413, ENST00000372414, 
ENST00000422171, ENST00000496447, 
ENST00000420304, ENST00000366820, 
ENST00000474493, 
Fusion gene scores* DoF score22 X 15 X 12=39603 X 2 X 3=18
# samples 243
** MAII scorelog2(24/3960*10)=-4.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PTPRF [Title/Abstract] AND LEFTY2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPTPRF(44019612)-LEFTY2(226127702), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPRF

GO:0099560

synaptic membrane adhesion

26321637


check buttonFusion gene breakpoints across PTPRF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across LEFTY2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A18J-01APTPRFchr1

44019612

+LEFTY2chr1

226127702

-
ChimerDB4BRCATCGA-BH-A18J-01APTPRFchr1

44019612

+LEFTY2chr1

226127702

-


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Fusion Gene ORF analysis for PTPRF-LEFTY2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000359947ENST00000420304PTPRFchr1

44019612

+LEFTY2chr1

226127702

-
In-frameENST00000359947ENST00000366820PTPRFchr1

44019612

+LEFTY2chr1

226127702

-
5CDS-5UTRENST00000359947ENST00000474493PTPRFchr1

44019612

+LEFTY2chr1

226127702

-
In-frameENST00000438120ENST00000420304PTPRFchr1

44019612

+LEFTY2chr1

226127702

-
In-frameENST00000438120ENST00000366820PTPRFchr1

44019612

+LEFTY2chr1

226127702

-
5CDS-5UTRENST00000438120ENST00000474493PTPRFchr1

44019612

+LEFTY2chr1

226127702

-
In-frameENST00000372413ENST00000420304PTPRFchr1

44019612

+LEFTY2chr1

226127702

-
In-frameENST00000372413ENST00000366820PTPRFchr1

44019612

+LEFTY2chr1

226127702

-
5CDS-5UTRENST00000372413ENST00000474493PTPRFchr1

44019612

+LEFTY2chr1

226127702

-
In-frameENST00000372414ENST00000420304PTPRFchr1

44019612

+LEFTY2chr1

226127702

-
In-frameENST00000372414ENST00000366820PTPRFchr1

44019612

+LEFTY2chr1

226127702

-
5CDS-5UTRENST00000372414ENST00000474493PTPRFchr1

44019612

+LEFTY2chr1

226127702

-
intron-3CDSENST00000422171ENST00000420304PTPRFchr1

44019612

+LEFTY2chr1

226127702

-
intron-3CDSENST00000422171ENST00000366820PTPRFchr1

44019612

+LEFTY2chr1

226127702

-
intron-5UTRENST00000422171ENST00000474493PTPRFchr1

44019612

+LEFTY2chr1

226127702

-
intron-3CDSENST00000496447ENST00000420304PTPRFchr1

44019612

+LEFTY2chr1

226127702

-
intron-3CDSENST00000496447ENST00000366820PTPRFchr1

44019612

+LEFTY2chr1

226127702

-
intron-5UTRENST00000496447ENST00000474493PTPRFchr1

44019612

+LEFTY2chr1

226127702

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000359947PTPRFchr144019612+ENST00000420304LEFTY2chr1226127702-23117193101467385
ENST00000359947PTPRFchr144019612+ENST00000366820LEFTY2chr1226127702-24077193101569419
ENST00000438120PTPRFchr144019612+ENST00000420304LEFTY2chr1226127702-22977052961453385
ENST00000438120PTPRFchr144019612+ENST00000366820LEFTY2chr1226127702-23937052961555419
ENST00000372413PTPRFchr144019612+ENST00000420304LEFTY2chr1226127702-2017425161173385
ENST00000372413PTPRFchr144019612+ENST00000366820LEFTY2chr1226127702-2113425161275419
ENST00000372414PTPRFchr144019612+ENST00000420304LEFTY2chr1226127702-2017425161173385
ENST00000372414PTPRFchr144019612+ENST00000366820LEFTY2chr1226127702-2113425161275419

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000359947ENST00000420304PTPRFchr144019612+LEFTY2chr1226127702-0.163375110.8366249
ENST00000359947ENST00000366820PTPRFchr144019612+LEFTY2chr1226127702-0.160713550.8392864
ENST00000438120ENST00000420304PTPRFchr144019612+LEFTY2chr1226127702-0.161975890.83802414
ENST00000438120ENST00000366820PTPRFchr144019612+LEFTY2chr1226127702-0.158950570.8410494
ENST00000372413ENST00000420304PTPRFchr144019612+LEFTY2chr1226127702-0.1193360.880664
ENST00000372413ENST00000366820PTPRFchr144019612+LEFTY2chr1226127702-0.142364560.8576355
ENST00000372414ENST00000420304PTPRFchr144019612+LEFTY2chr1226127702-0.1193360.880664
ENST00000372414ENST00000366820PTPRFchr144019612+LEFTY2chr1226127702-0.142364560.8576355

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Fusion Genomic Features for PTPRF-LEFTY2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PTPRF-LEFTY2


check button Go to

FGviewer for the breakpoints of chr1:44019612-chr1:226127702

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPRFchr1:44019612chr1:226127702ENST00000359947+53433_123126.333333333333331908.0DomainNote=Ig-like C2-type 1
HgenePTPRFchr1:44019612chr1:226127702ENST00000372413+33133_123126.333333333333331899.0DomainNote=Ig-like C2-type 1
HgenePTPRFchr1:44019612chr1:226127702ENST00000372414+33233_123126.333333333333331908.0DomainNote=Ig-like C2-type 1
HgenePTPRFchr1:44019612chr1:226127702ENST00000438120+53333_123126.333333333333331899.0DomainNote=Ig-like C2-type 1
HgenePTPRFchr1:44019612chr1:226127702ENST00000359947+53468_77126.333333333333331908.0RegionHeparin-binding
HgenePTPRFchr1:44019612chr1:226127702ENST00000372413+33168_77126.333333333333331899.0RegionHeparin-binding
HgenePTPRFchr1:44019612chr1:226127702ENST00000372414+33268_77126.333333333333331908.0RegionHeparin-binding
HgenePTPRFchr1:44019612chr1:226127702ENST00000438120+53368_77126.333333333333331899.0RegionHeparin-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPRFchr1:44019612chr1:226127702ENST00000359947+5341014_1098126.333333333333331908.0DomainFibronectin type-III 8
HgenePTPRFchr1:44019612chr1:226127702ENST00000359947+5341352_1607126.333333333333331908.0DomainTyrosine-protein phosphatase 1
HgenePTPRFchr1:44019612chr1:226127702ENST00000359947+534135_224126.333333333333331908.0DomainNote=Ig-like C2-type 2
HgenePTPRFchr1:44019612chr1:226127702ENST00000359947+5341639_1898126.333333333333331908.0DomainTyrosine-protein phosphatase 2
HgenePTPRFchr1:44019612chr1:226127702ENST00000359947+534232_314126.333333333333331908.0DomainNote=Ig-like C2-type 3
HgenePTPRFchr1:44019612chr1:226127702ENST00000359947+534321_411126.333333333333331908.0DomainFibronectin type-III 1
HgenePTPRFchr1:44019612chr1:226127702ENST00000359947+534416_510126.333333333333331908.0DomainFibronectin type-III 2
HgenePTPRFchr1:44019612chr1:226127702ENST00000359947+534514_604126.333333333333331908.0DomainFibronectin type-III 3
HgenePTPRFchr1:44019612chr1:226127702ENST00000359947+534609_706126.333333333333331908.0DomainFibronectin type-III 4
HgenePTPRFchr1:44019612chr1:226127702ENST00000359947+534711_819126.333333333333331908.0DomainFibronectin type-III 5
HgenePTPRFchr1:44019612chr1:226127702ENST00000359947+534820_914126.333333333333331908.0DomainFibronectin type-III 6
HgenePTPRFchr1:44019612chr1:226127702ENST00000359947+534918_1010126.333333333333331908.0DomainFibronectin type-III 7
HgenePTPRFchr1:44019612chr1:226127702ENST00000372413+3311014_1098126.333333333333331899.0DomainFibronectin type-III 8
HgenePTPRFchr1:44019612chr1:226127702ENST00000372413+3311352_1607126.333333333333331899.0DomainTyrosine-protein phosphatase 1
HgenePTPRFchr1:44019612chr1:226127702ENST00000372413+331135_224126.333333333333331899.0DomainNote=Ig-like C2-type 2
HgenePTPRFchr1:44019612chr1:226127702ENST00000372413+3311639_1898126.333333333333331899.0DomainTyrosine-protein phosphatase 2
HgenePTPRFchr1:44019612chr1:226127702ENST00000372413+331232_314126.333333333333331899.0DomainNote=Ig-like C2-type 3
HgenePTPRFchr1:44019612chr1:226127702ENST00000372413+331321_411126.333333333333331899.0DomainFibronectin type-III 1
HgenePTPRFchr1:44019612chr1:226127702ENST00000372413+331416_510126.333333333333331899.0DomainFibronectin type-III 2
HgenePTPRFchr1:44019612chr1:226127702ENST00000372413+331514_604126.333333333333331899.0DomainFibronectin type-III 3
HgenePTPRFchr1:44019612chr1:226127702ENST00000372413+331609_706126.333333333333331899.0DomainFibronectin type-III 4
HgenePTPRFchr1:44019612chr1:226127702ENST00000372413+331711_819126.333333333333331899.0DomainFibronectin type-III 5
HgenePTPRFchr1:44019612chr1:226127702ENST00000372413+331820_914126.333333333333331899.0DomainFibronectin type-III 6
HgenePTPRFchr1:44019612chr1:226127702ENST00000372413+331918_1010126.333333333333331899.0DomainFibronectin type-III 7
HgenePTPRFchr1:44019612chr1:226127702ENST00000372414+3321014_1098126.333333333333331908.0DomainFibronectin type-III 8
HgenePTPRFchr1:44019612chr1:226127702ENST00000372414+3321352_1607126.333333333333331908.0DomainTyrosine-protein phosphatase 1
HgenePTPRFchr1:44019612chr1:226127702ENST00000372414+332135_224126.333333333333331908.0DomainNote=Ig-like C2-type 2
HgenePTPRFchr1:44019612chr1:226127702ENST00000372414+3321639_1898126.333333333333331908.0DomainTyrosine-protein phosphatase 2
HgenePTPRFchr1:44019612chr1:226127702ENST00000372414+332232_314126.333333333333331908.0DomainNote=Ig-like C2-type 3
HgenePTPRFchr1:44019612chr1:226127702ENST00000372414+332321_411126.333333333333331908.0DomainFibronectin type-III 1
HgenePTPRFchr1:44019612chr1:226127702ENST00000372414+332416_510126.333333333333331908.0DomainFibronectin type-III 2
HgenePTPRFchr1:44019612chr1:226127702ENST00000372414+332514_604126.333333333333331908.0DomainFibronectin type-III 3
HgenePTPRFchr1:44019612chr1:226127702ENST00000372414+332609_706126.333333333333331908.0DomainFibronectin type-III 4
HgenePTPRFchr1:44019612chr1:226127702ENST00000372414+332711_819126.333333333333331908.0DomainFibronectin type-III 5
HgenePTPRFchr1:44019612chr1:226127702ENST00000372414+332820_914126.333333333333331908.0DomainFibronectin type-III 6
HgenePTPRFchr1:44019612chr1:226127702ENST00000372414+332918_1010126.333333333333331908.0DomainFibronectin type-III 7
HgenePTPRFchr1:44019612chr1:226127702ENST00000438120+5331014_1098126.333333333333331899.0DomainFibronectin type-III 8
HgenePTPRFchr1:44019612chr1:226127702ENST00000438120+5331352_1607126.333333333333331899.0DomainTyrosine-protein phosphatase 1
HgenePTPRFchr1:44019612chr1:226127702ENST00000438120+533135_224126.333333333333331899.0DomainNote=Ig-like C2-type 2
HgenePTPRFchr1:44019612chr1:226127702ENST00000438120+5331639_1898126.333333333333331899.0DomainTyrosine-protein phosphatase 2
HgenePTPRFchr1:44019612chr1:226127702ENST00000438120+533232_314126.333333333333331899.0DomainNote=Ig-like C2-type 3
HgenePTPRFchr1:44019612chr1:226127702ENST00000438120+533321_411126.333333333333331899.0DomainFibronectin type-III 1
HgenePTPRFchr1:44019612chr1:226127702ENST00000438120+533416_510126.333333333333331899.0DomainFibronectin type-III 2
HgenePTPRFchr1:44019612chr1:226127702ENST00000438120+533514_604126.333333333333331899.0DomainFibronectin type-III 3
HgenePTPRFchr1:44019612chr1:226127702ENST00000438120+533609_706126.333333333333331899.0DomainFibronectin type-III 4
HgenePTPRFchr1:44019612chr1:226127702ENST00000438120+533711_819126.333333333333331899.0DomainFibronectin type-III 5
HgenePTPRFchr1:44019612chr1:226127702ENST00000438120+533820_914126.333333333333331899.0DomainFibronectin type-III 6
HgenePTPRFchr1:44019612chr1:226127702ENST00000438120+533918_1010126.333333333333331899.0DomainFibronectin type-III 7
HgenePTPRFchr1:44019612chr1:226127702ENST00000359947+5341548_1554126.333333333333331908.0RegionSubstrate binding
HgenePTPRFchr1:44019612chr1:226127702ENST00000372413+3311548_1554126.333333333333331899.0RegionSubstrate binding
HgenePTPRFchr1:44019612chr1:226127702ENST00000372414+3321548_1554126.333333333333331908.0RegionSubstrate binding
HgenePTPRFchr1:44019612chr1:226127702ENST00000438120+5331548_1554126.333333333333331899.0RegionSubstrate binding
HgenePTPRFchr1:44019612chr1:226127702ENST00000359947+5341285_1907126.333333333333331908.0Topological domainCytoplasmic
HgenePTPRFchr1:44019612chr1:226127702ENST00000359947+53430_1263126.333333333333331908.0Topological domainExtracellular
HgenePTPRFchr1:44019612chr1:226127702ENST00000372413+3311285_1907126.333333333333331899.0Topological domainCytoplasmic
HgenePTPRFchr1:44019612chr1:226127702ENST00000372413+33130_1263126.333333333333331899.0Topological domainExtracellular
HgenePTPRFchr1:44019612chr1:226127702ENST00000372414+3321285_1907126.333333333333331908.0Topological domainCytoplasmic
HgenePTPRFchr1:44019612chr1:226127702ENST00000372414+33230_1263126.333333333333331908.0Topological domainExtracellular
HgenePTPRFchr1:44019612chr1:226127702ENST00000438120+5331285_1907126.333333333333331899.0Topological domainCytoplasmic
HgenePTPRFchr1:44019612chr1:226127702ENST00000438120+53330_1263126.333333333333331899.0Topological domainExtracellular
HgenePTPRFchr1:44019612chr1:226127702ENST00000359947+5341264_1284126.333333333333331908.0TransmembraneHelical
HgenePTPRFchr1:44019612chr1:226127702ENST00000372413+3311264_1284126.333333333333331899.0TransmembraneHelical
HgenePTPRFchr1:44019612chr1:226127702ENST00000372414+3321264_1284126.333333333333331908.0TransmembraneHelical
HgenePTPRFchr1:44019612chr1:226127702ENST00000438120+5331264_1284126.333333333333331899.0TransmembraneHelical


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Fusion Gene Sequence for PTPRF-LEFTY2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000359947_ENST00000420304_TCGA-BH-A18J-01A_PTPRF_chr1_44019612_+_LEFTY2_chr1_226127702_length(transcript)=2311nt_BP=719nt
CGGGAGCGGCGGGAGCGGTGGCGGCGGCAGAGGCGGCGGCTCCAGCTTCGGCTCCGGCTCGGGCTCGGGCTCCGGCTCCGGCTCCGGCTC
CGGCTCCAGCTCGGGTGGCGGTGGCGGGAGCGGGACCAGGTGGAGGCGGCGGCGGCAGAGGAGTGGGAGCAGCGGCCCTAGCGGCTTGCG
GGGGGACATGCGGACCGACGGCCCCTGGATAGGCGGAAGGAGTGGAGGCCCTGGTGCCCGGCCCTTGGTGCTGAGTATCCAGCAAGAGTG
ACCGGGGTGAAGAAGCAAAGACTCGGTTGATTGTCCTGGGCTGTGGCTGGCTGTGGAGCTAGAGCCCTGGATGGCCCCTGAGCCAGCCCC
AGGGAGGACGATGGTGCCCCTTGTGCCTGCACTGGTGATGCTTGGTTTGGTGGCAGGCGCCCATGGTGACAGCAAACCTGTCTTCATTAA
AGTCCCTGAGGACCAGACTGGGCTGTCAGGAGGGGTAGCCTCCTTCGTGTGCCAAGCTACAGGAGAACCCAAGCCGCGCATCACATGGAT
GAAGAAGGGGAAGAAAGTCAGCTCCCAGCGCTTCGAGGTCATTGAGTTTGATGATGGGGCAGGGTCAGTGCTTCGGATCCAGCCATTGCG
GGTGCAGCGAGATGAAGCCATCTATGAGTGTACAGCTACTAACAGCCTGGGTGAGATCAACACTAGTGCCAAGCTCTCAGTGCTCGAAGA
GGTGGCCGGCAGGTTCCTGGCGTCGGAGGCCGCGCTGCACAGGCACGGGCGGCTGTCCCCGCGCAGCGCCCAGGCCCGGGTGACCGTCGA
GTGGCTGCGCGTCCGCGACGACGGCTCCAACCGCACCTCCCTCATCGACTCCAGGCTGGTGTCCGTCCACGAGAGCGGCTGGAAGGCCTT
CGACGTGACCGAGGCCGTGAACTTCTGGCAGCAGCTGAGCCGGCCCCGGCAGCCGCTGCTGCTACAGGTGTCGGTGCAGAGGGAGCATCT
GGGCCCGCTGGCGTCCGGCGCCCACAAGCTGGTCCGCTTTGCCTCGCAGGGGGCGCCAGCCGGGCTTGGGGAGCCCCAGCTGGAGCTGCA
CACCCTGGACCTCAGGGACTATGGAGCTCAGGGCGACTGTGACCCTGAAGCACCAATGACCGAGGGCACCCGCTGCTGCCGCCAGGAGAT
GTACATTGACCTGCAGGGGATGAAGTGGGCCAAGAACTGGGTGCTGGAGCCCCCGGGCTTCCTGGCTTACGAGTGTGTGGGCACCTGCCA
GCAGCCCCCGGAGGCCCTGGCCTTCAATTGGCCATTTCTGGGGCCGCGACAGTGTATCGCCTCGGAGACTGCCTCGCTGCCCATGATCGT
CAGCATCAAGGAGGGAGGCAGGACCAGGCCCCAGGTGGTCAGCCTGCCCAACATGAGGGTGCAGAAGTGCAGCTGTGCCTCGGATGGGGC
GCTCGTGCCAAGGAGGCTCCAGCCATAGGCGCCTGGTGTATCCATTGAGCCCTCTAACTGAACGTGTGCATAGAGGTGGTCTTAATGTAG
GTCTTAACTTTATACTTAGCAAGTTACTCCATCCCAATTTAGTGCTCCTGTGTGACCTTCGCCCTGTGTCCTTCCATTTCCTGTCTTTCC
CGTCCATCACCCATCCTAAGCACTTACGTGAGTAAATAATGCAGCTCAGATGCTGAGCTCTAGTAGGAAATGCTGGCATGCTGATTACAA
GATACAGCTGAGCAATGCACACATTTTCAGCTGGGAGTTTCTGTTCTCTGGCAAATTCTTCACTGAGTCTGGAACAATAATACCCTATGA
TTAGAACTGGGGAAACAGAACTGAATTGCTGTGTTATATGAGGAATTAAAACCTTCAAATCTCTATTTCCCCCAAATACTGACCCATTCT
GGACTTTTGTAAACATACCTAGGCCCCTGTTCCCCTGAGAGGGTGCTAAGAGGAAGGATGAAGGGCTTCAGGCTGGGGGCAGTGGACAGG
GAATTGGGATACCTGGATTCTGGTTCTGACAGGGCCACAAGCTAGGATCTCTAACAAACGCAGAAGGCTTTGGCTCGTCATTTCCTCTTA
AAAAGGAGGAGCTGGGCTTCAGCTCTAAGAACTTCATTGCCCTGGGGATCAGACAGCCCCTACCTACCCCTGCCCACTCCTCTGGAGACT
GAGCCTTGCCCGTGCATATTTAGGTCATTTCCCACACTGTCTTAGAGAACTTGTCACCAGAAACCACATGTATTTGCATGTTTTTTGTTA

>In-frame_ENST00000359947_ENST00000420304_TCGA-BH-A18J-01A_PTPRF_chr1_44019612_+_LEFTY2_chr1_226127702_length(amino acids)=385AA_start in transcript=310_stop in transcript=1467
MWLAVELEPWMAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEV
IEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEVAGRFLASEAALHRHGRLSPRSAQARVTVEWLRVRDDGSNRTS
LIDSRLVSVHESGWKAFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPLASGAHKLVRFASQGAPAGLGEPQLELHTLDLRDYGAQGDC
DPEAPMTEGTRCCRQEMYIDLQGMKWAKNWVLEPPGFLAYECVGTCQQPPEALAFNWPFLGPRQCIASETASLPMIVSIKEGGRTRPQVV

--------------------------------------------------------------
>In-frame_ENST00000359947_ENST00000366820_TCGA-BH-A18J-01A_PTPRF_chr1_44019612_+_LEFTY2_chr1_226127702_length(transcript)=2407nt_BP=719nt
CGGGAGCGGCGGGAGCGGTGGCGGCGGCAGAGGCGGCGGCTCCAGCTTCGGCTCCGGCTCGGGCTCGGGCTCCGGCTCCGGCTCCGGCTC
CGGCTCCAGCTCGGGTGGCGGTGGCGGGAGCGGGACCAGGTGGAGGCGGCGGCGGCAGAGGAGTGGGAGCAGCGGCCCTAGCGGCTTGCG
GGGGGACATGCGGACCGACGGCCCCTGGATAGGCGGAAGGAGTGGAGGCCCTGGTGCCCGGCCCTTGGTGCTGAGTATCCAGCAAGAGTG
ACCGGGGTGAAGAAGCAAAGACTCGGTTGATTGTCCTGGGCTGTGGCTGGCTGTGGAGCTAGAGCCCTGGATGGCCCCTGAGCCAGCCCC
AGGGAGGACGATGGTGCCCCTTGTGCCTGCACTGGTGATGCTTGGTTTGGTGGCAGGCGCCCATGGTGACAGCAAACCTGTCTTCATTAA
AGTCCCTGAGGACCAGACTGGGCTGTCAGGAGGGGTAGCCTCCTTCGTGTGCCAAGCTACAGGAGAACCCAAGCCGCGCATCACATGGAT
GAAGAAGGGGAAGAAAGTCAGCTCCCAGCGCTTCGAGGTCATTGAGTTTGATGATGGGGCAGGGTCAGTGCTTCGGATCCAGCCATTGCG
GGTGCAGCGAGATGAAGCCATCTATGAGTGTACAGCTACTAACAGCCTGGGTGAGATCAACACTAGTGCCAAGCTCTCAGTGCTCGAAGA
GGTGGCCGGCAGGTTCCTGGCGTCGGAGGCCAGCACACACCTGCTGGTGTTCGGCATGGAGCAGCGGCTGCCGCCCAACAGCGAGCTGGT
GCAGGCCGTGCTGCGGCTCTTCCAGGAGCCGGTCCCCAAGGCCGCGCTGCACAGGCACGGGCGGCTGTCCCCGCGCAGCGCCCAGGCCCG
GGTGACCGTCGAGTGGCTGCGCGTCCGCGACGACGGCTCCAACCGCACCTCCCTCATCGACTCCAGGCTGGTGTCCGTCCACGAGAGCGG
CTGGAAGGCCTTCGACGTGACCGAGGCCGTGAACTTCTGGCAGCAGCTGAGCCGGCCCCGGCAGCCGCTGCTGCTACAGGTGTCGGTGCA
GAGGGAGCATCTGGGCCCGCTGGCGTCCGGCGCCCACAAGCTGGTCCGCTTTGCCTCGCAGGGGGCGCCAGCCGGGCTTGGGGAGCCCCA
GCTGGAGCTGCACACCCTGGACCTCAGGGACTATGGAGCTCAGGGCGACTGTGACCCTGAAGCACCAATGACCGAGGGCACCCGCTGCTG
CCGCCAGGAGATGTACATTGACCTGCAGGGGATGAAGTGGGCCAAGAACTGGGTGCTGGAGCCCCCGGGCTTCCTGGCTTACGAGTGTGT
GGGCACCTGCCAGCAGCCCCCGGAGGCCCTGGCCTTCAATTGGCCATTTCTGGGGCCGCGACAGTGTATCGCCTCGGAGACTGCCTCGCT
GCCCATGATCGTCAGCATCAAGGAGGGAGGCAGGACCAGGCCCCAGGTGGTCAGCCTGCCCAACATGAGGGTGCAGAAGTGCAGCTGTGC
CTCGGATGGGGCGCTCGTGCCAAGGAGGCTCCAGCCATAGGCGCCTGGTGTATCCATTGAGCCCTCTAACTGAACGTGTGCATAGAGGTG
GTCTTAATGTAGGTCTTAACTTTATACTTAGCAAGTTACTCCATCCCAATTTAGTGCTCCTGTGTGACCTTCGCCCTGTGTCCTTCCATT
TCCTGTCTTTCCCGTCCATCACCCATCCTAAGCACTTACGTGAGTAAATAATGCAGCTCAGATGCTGAGCTCTAGTAGGAAATGCTGGCA
TGCTGATTACAAGATACAGCTGAGCAATGCACACATTTTCAGCTGGGAGTTTCTGTTCTCTGGCAAATTCTTCACTGAGTCTGGAACAAT
AATACCCTATGATTAGAACTGGGGAAACAGAACTGAATTGCTGTGTTATATGAGGAATTAAAACCTTCAAATCTCTATTTCCCCCAAATA
CTGACCCATTCTGGACTTTTGTAAACATACCTAGGCCCCTGTTCCCCTGAGAGGGTGCTAAGAGGAAGGATGAAGGGCTTCAGGCTGGGG
GCAGTGGACAGGGAATTGGGATACCTGGATTCTGGTTCTGACAGGGCCACAAGCTAGGATCTCTAACAAACGCAGAAGGCTTTGGCTCGT
CATTTCCTCTTAAAAAGGAGGAGCTGGGCTTCAGCTCTAAGAACTTCATTGCCCTGGGGATCAGACAGCCCCTACCTACCCCTGCCCACT
CCTCTGGAGACTGAGCCTTGCCCGTGCATATTTAGGTCATTTCCCACACTGTCTTAGAGAACTTGTCACCAGAAACCACATGTATTTGCA

>In-frame_ENST00000359947_ENST00000366820_TCGA-BH-A18J-01A_PTPRF_chr1_44019612_+_LEFTY2_chr1_226127702_length(amino acids)=419AA_start in transcript=310_stop in transcript=1569
MWLAVELEPWMAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEV
IEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEVAGRFLASEASTHLLVFGMEQRLPPNSELVQAVLRLFQEPVPK
AALHRHGRLSPRSAQARVTVEWLRVRDDGSNRTSLIDSRLVSVHESGWKAFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPLASGAHK
LVRFASQGAPAGLGEPQLELHTLDLRDYGAQGDCDPEAPMTEGTRCCRQEMYIDLQGMKWAKNWVLEPPGFLAYECVGTCQQPPEALAFN

--------------------------------------------------------------
>In-frame_ENST00000438120_ENST00000420304_TCGA-BH-A18J-01A_PTPRF_chr1_44019612_+_LEFTY2_chr1_226127702_length(transcript)=2297nt_BP=705nt
GCGGTGGCGGCGGCAGAGGCGGCGGCTCCAGCTTCGGCTCCGGCTCGGGCTCGGGCTCCGGCTCCGGCTCCGGCTCCGGCTCCAGCTCGG
GTGGCGGTGGCGGGAGCGGGACCAGGTGGAGGCGGCGGCGGCAGAGGAGTGGGAGCAGCGGCCCTAGCGGCTTGCGGGGGGACATGCGGA
CCGACGGCCCCTGGATAGGCGGAAGGAGTGGAGGCCCTGGTGCCCGGCCCTTGGTGCTGAGTATCCAGCAAGAGTGACCGGGGTGAAGAA
GCAAAGACTCGGTTGATTGTCCTGGGCTGTGGCTGGCTGTGGAGCTAGAGCCCTGGATGGCCCCTGAGCCAGCCCCAGGGAGGACGATGG
TGCCCCTTGTGCCTGCACTGGTGATGCTTGGTTTGGTGGCAGGCGCCCATGGTGACAGCAAACCTGTCTTCATTAAAGTCCCTGAGGACC
AGACTGGGCTGTCAGGAGGGGTAGCCTCCTTCGTGTGCCAAGCTACAGGAGAACCCAAGCCGCGCATCACATGGATGAAGAAGGGGAAGA
AAGTCAGCTCCCAGCGCTTCGAGGTCATTGAGTTTGATGATGGGGCAGGGTCAGTGCTTCGGATCCAGCCATTGCGGGTGCAGCGAGATG
AAGCCATCTATGAGTGTACAGCTACTAACAGCCTGGGTGAGATCAACACTAGTGCCAAGCTCTCAGTGCTCGAAGAGGTGGCCGGCAGGT
TCCTGGCGTCGGAGGCCGCGCTGCACAGGCACGGGCGGCTGTCCCCGCGCAGCGCCCAGGCCCGGGTGACCGTCGAGTGGCTGCGCGTCC
GCGACGACGGCTCCAACCGCACCTCCCTCATCGACTCCAGGCTGGTGTCCGTCCACGAGAGCGGCTGGAAGGCCTTCGACGTGACCGAGG
CCGTGAACTTCTGGCAGCAGCTGAGCCGGCCCCGGCAGCCGCTGCTGCTACAGGTGTCGGTGCAGAGGGAGCATCTGGGCCCGCTGGCGT
CCGGCGCCCACAAGCTGGTCCGCTTTGCCTCGCAGGGGGCGCCAGCCGGGCTTGGGGAGCCCCAGCTGGAGCTGCACACCCTGGACCTCA
GGGACTATGGAGCTCAGGGCGACTGTGACCCTGAAGCACCAATGACCGAGGGCACCCGCTGCTGCCGCCAGGAGATGTACATTGACCTGC
AGGGGATGAAGTGGGCCAAGAACTGGGTGCTGGAGCCCCCGGGCTTCCTGGCTTACGAGTGTGTGGGCACCTGCCAGCAGCCCCCGGAGG
CCCTGGCCTTCAATTGGCCATTTCTGGGGCCGCGACAGTGTATCGCCTCGGAGACTGCCTCGCTGCCCATGATCGTCAGCATCAAGGAGG
GAGGCAGGACCAGGCCCCAGGTGGTCAGCCTGCCCAACATGAGGGTGCAGAAGTGCAGCTGTGCCTCGGATGGGGCGCTCGTGCCAAGGA
GGCTCCAGCCATAGGCGCCTGGTGTATCCATTGAGCCCTCTAACTGAACGTGTGCATAGAGGTGGTCTTAATGTAGGTCTTAACTTTATA
CTTAGCAAGTTACTCCATCCCAATTTAGTGCTCCTGTGTGACCTTCGCCCTGTGTCCTTCCATTTCCTGTCTTTCCCGTCCATCACCCAT
CCTAAGCACTTACGTGAGTAAATAATGCAGCTCAGATGCTGAGCTCTAGTAGGAAATGCTGGCATGCTGATTACAAGATACAGCTGAGCA
ATGCACACATTTTCAGCTGGGAGTTTCTGTTCTCTGGCAAATTCTTCACTGAGTCTGGAACAATAATACCCTATGATTAGAACTGGGGAA
ACAGAACTGAATTGCTGTGTTATATGAGGAATTAAAACCTTCAAATCTCTATTTCCCCCAAATACTGACCCATTCTGGACTTTTGTAAAC
ATACCTAGGCCCCTGTTCCCCTGAGAGGGTGCTAAGAGGAAGGATGAAGGGCTTCAGGCTGGGGGCAGTGGACAGGGAATTGGGATACCT
GGATTCTGGTTCTGACAGGGCCACAAGCTAGGATCTCTAACAAACGCAGAAGGCTTTGGCTCGTCATTTCCTCTTAAAAAGGAGGAGCTG
GGCTTCAGCTCTAAGAACTTCATTGCCCTGGGGATCAGACAGCCCCTACCTACCCCTGCCCACTCCTCTGGAGACTGAGCCTTGCCCGTG
CATATTTAGGTCATTTCCCACACTGTCTTAGAGAACTTGTCACCAGAAACCACATGTATTTGCATGTTTTTTGTTAATTTAGCTAAAGCA

>In-frame_ENST00000438120_ENST00000420304_TCGA-BH-A18J-01A_PTPRF_chr1_44019612_+_LEFTY2_chr1_226127702_length(amino acids)=385AA_start in transcript=296_stop in transcript=1453
MWLAVELEPWMAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEV
IEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEVAGRFLASEAALHRHGRLSPRSAQARVTVEWLRVRDDGSNRTS
LIDSRLVSVHESGWKAFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPLASGAHKLVRFASQGAPAGLGEPQLELHTLDLRDYGAQGDC
DPEAPMTEGTRCCRQEMYIDLQGMKWAKNWVLEPPGFLAYECVGTCQQPPEALAFNWPFLGPRQCIASETASLPMIVSIKEGGRTRPQVV

--------------------------------------------------------------
>In-frame_ENST00000438120_ENST00000366820_TCGA-BH-A18J-01A_PTPRF_chr1_44019612_+_LEFTY2_chr1_226127702_length(transcript)=2393nt_BP=705nt
GCGGTGGCGGCGGCAGAGGCGGCGGCTCCAGCTTCGGCTCCGGCTCGGGCTCGGGCTCCGGCTCCGGCTCCGGCTCCGGCTCCAGCTCGG
GTGGCGGTGGCGGGAGCGGGACCAGGTGGAGGCGGCGGCGGCAGAGGAGTGGGAGCAGCGGCCCTAGCGGCTTGCGGGGGGACATGCGGA
CCGACGGCCCCTGGATAGGCGGAAGGAGTGGAGGCCCTGGTGCCCGGCCCTTGGTGCTGAGTATCCAGCAAGAGTGACCGGGGTGAAGAA
GCAAAGACTCGGTTGATTGTCCTGGGCTGTGGCTGGCTGTGGAGCTAGAGCCCTGGATGGCCCCTGAGCCAGCCCCAGGGAGGACGATGG
TGCCCCTTGTGCCTGCACTGGTGATGCTTGGTTTGGTGGCAGGCGCCCATGGTGACAGCAAACCTGTCTTCATTAAAGTCCCTGAGGACC
AGACTGGGCTGTCAGGAGGGGTAGCCTCCTTCGTGTGCCAAGCTACAGGAGAACCCAAGCCGCGCATCACATGGATGAAGAAGGGGAAGA
AAGTCAGCTCCCAGCGCTTCGAGGTCATTGAGTTTGATGATGGGGCAGGGTCAGTGCTTCGGATCCAGCCATTGCGGGTGCAGCGAGATG
AAGCCATCTATGAGTGTACAGCTACTAACAGCCTGGGTGAGATCAACACTAGTGCCAAGCTCTCAGTGCTCGAAGAGGTGGCCGGCAGGT
TCCTGGCGTCGGAGGCCAGCACACACCTGCTGGTGTTCGGCATGGAGCAGCGGCTGCCGCCCAACAGCGAGCTGGTGCAGGCCGTGCTGC
GGCTCTTCCAGGAGCCGGTCCCCAAGGCCGCGCTGCACAGGCACGGGCGGCTGTCCCCGCGCAGCGCCCAGGCCCGGGTGACCGTCGAGT
GGCTGCGCGTCCGCGACGACGGCTCCAACCGCACCTCCCTCATCGACTCCAGGCTGGTGTCCGTCCACGAGAGCGGCTGGAAGGCCTTCG
ACGTGACCGAGGCCGTGAACTTCTGGCAGCAGCTGAGCCGGCCCCGGCAGCCGCTGCTGCTACAGGTGTCGGTGCAGAGGGAGCATCTGG
GCCCGCTGGCGTCCGGCGCCCACAAGCTGGTCCGCTTTGCCTCGCAGGGGGCGCCAGCCGGGCTTGGGGAGCCCCAGCTGGAGCTGCACA
CCCTGGACCTCAGGGACTATGGAGCTCAGGGCGACTGTGACCCTGAAGCACCAATGACCGAGGGCACCCGCTGCTGCCGCCAGGAGATGT
ACATTGACCTGCAGGGGATGAAGTGGGCCAAGAACTGGGTGCTGGAGCCCCCGGGCTTCCTGGCTTACGAGTGTGTGGGCACCTGCCAGC
AGCCCCCGGAGGCCCTGGCCTTCAATTGGCCATTTCTGGGGCCGCGACAGTGTATCGCCTCGGAGACTGCCTCGCTGCCCATGATCGTCA
GCATCAAGGAGGGAGGCAGGACCAGGCCCCAGGTGGTCAGCCTGCCCAACATGAGGGTGCAGAAGTGCAGCTGTGCCTCGGATGGGGCGC
TCGTGCCAAGGAGGCTCCAGCCATAGGCGCCTGGTGTATCCATTGAGCCCTCTAACTGAACGTGTGCATAGAGGTGGTCTTAATGTAGGT
CTTAACTTTATACTTAGCAAGTTACTCCATCCCAATTTAGTGCTCCTGTGTGACCTTCGCCCTGTGTCCTTCCATTTCCTGTCTTTCCCG
TCCATCACCCATCCTAAGCACTTACGTGAGTAAATAATGCAGCTCAGATGCTGAGCTCTAGTAGGAAATGCTGGCATGCTGATTACAAGA
TACAGCTGAGCAATGCACACATTTTCAGCTGGGAGTTTCTGTTCTCTGGCAAATTCTTCACTGAGTCTGGAACAATAATACCCTATGATT
AGAACTGGGGAAACAGAACTGAATTGCTGTGTTATATGAGGAATTAAAACCTTCAAATCTCTATTTCCCCCAAATACTGACCCATTCTGG
ACTTTTGTAAACATACCTAGGCCCCTGTTCCCCTGAGAGGGTGCTAAGAGGAAGGATGAAGGGCTTCAGGCTGGGGGCAGTGGACAGGGA
ATTGGGATACCTGGATTCTGGTTCTGACAGGGCCACAAGCTAGGATCTCTAACAAACGCAGAAGGCTTTGGCTCGTCATTTCCTCTTAAA
AAGGAGGAGCTGGGCTTCAGCTCTAAGAACTTCATTGCCCTGGGGATCAGACAGCCCCTACCTACCCCTGCCCACTCCTCTGGAGACTGA
GCCTTGCCCGTGCATATTTAGGTCATTTCCCACACTGTCTTAGAGAACTTGTCACCAGAAACCACATGTATTTGCATGTTTTTTGTTAAT

>In-frame_ENST00000438120_ENST00000366820_TCGA-BH-A18J-01A_PTPRF_chr1_44019612_+_LEFTY2_chr1_226127702_length(amino acids)=419AA_start in transcript=296_stop in transcript=1555
MWLAVELEPWMAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEV
IEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEVAGRFLASEASTHLLVFGMEQRLPPNSELVQAVLRLFQEPVPK
AALHRHGRLSPRSAQARVTVEWLRVRDDGSNRTSLIDSRLVSVHESGWKAFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPLASGAHK
LVRFASQGAPAGLGEPQLELHTLDLRDYGAQGDCDPEAPMTEGTRCCRQEMYIDLQGMKWAKNWVLEPPGFLAYECVGTCQQPPEALAFN

--------------------------------------------------------------
>In-frame_ENST00000372413_ENST00000420304_TCGA-BH-A18J-01A_PTPRF_chr1_44019612_+_LEFTY2_chr1_226127702_length(transcript)=2017nt_BP=425nt
GGTTGATTGTCCTGGGCTGTGGCTGGCTGTGGAGCTAGAGCCCTGGATGGCCCCTGAGCCAGCCCCAGGGAGGACGATGGTGCCCCTTGT
GCCTGCACTGGTGATGCTTGGTTTGGTGGCAGGCGCCCATGGTGACAGCAAACCTGTCTTCATTAAAGTCCCTGAGGACCAGACTGGGCT
GTCAGGAGGGGTAGCCTCCTTCGTGTGCCAAGCTACAGGAGAACCCAAGCCGCGCATCACATGGATGAAGAAGGGGAAGAAAGTCAGCTC
CCAGCGCTTCGAGGTCATTGAGTTTGATGATGGGGCAGGGTCAGTGCTTCGGATCCAGCCATTGCGGGTGCAGCGAGATGAAGCCATCTA
TGAGTGTACAGCTACTAACAGCCTGGGTGAGATCAACACTAGTGCCAAGCTCTCAGTGCTCGAAGAGGTGGCCGGCAGGTTCCTGGCGTC
GGAGGCCGCGCTGCACAGGCACGGGCGGCTGTCCCCGCGCAGCGCCCAGGCCCGGGTGACCGTCGAGTGGCTGCGCGTCCGCGACGACGG
CTCCAACCGCACCTCCCTCATCGACTCCAGGCTGGTGTCCGTCCACGAGAGCGGCTGGAAGGCCTTCGACGTGACCGAGGCCGTGAACTT
CTGGCAGCAGCTGAGCCGGCCCCGGCAGCCGCTGCTGCTACAGGTGTCGGTGCAGAGGGAGCATCTGGGCCCGCTGGCGTCCGGCGCCCA
CAAGCTGGTCCGCTTTGCCTCGCAGGGGGCGCCAGCCGGGCTTGGGGAGCCCCAGCTGGAGCTGCACACCCTGGACCTCAGGGACTATGG
AGCTCAGGGCGACTGTGACCCTGAAGCACCAATGACCGAGGGCACCCGCTGCTGCCGCCAGGAGATGTACATTGACCTGCAGGGGATGAA
GTGGGCCAAGAACTGGGTGCTGGAGCCCCCGGGCTTCCTGGCTTACGAGTGTGTGGGCACCTGCCAGCAGCCCCCGGAGGCCCTGGCCTT
CAATTGGCCATTTCTGGGGCCGCGACAGTGTATCGCCTCGGAGACTGCCTCGCTGCCCATGATCGTCAGCATCAAGGAGGGAGGCAGGAC
CAGGCCCCAGGTGGTCAGCCTGCCCAACATGAGGGTGCAGAAGTGCAGCTGTGCCTCGGATGGGGCGCTCGTGCCAAGGAGGCTCCAGCC
ATAGGCGCCTGGTGTATCCATTGAGCCCTCTAACTGAACGTGTGCATAGAGGTGGTCTTAATGTAGGTCTTAACTTTATACTTAGCAAGT
TACTCCATCCCAATTTAGTGCTCCTGTGTGACCTTCGCCCTGTGTCCTTCCATTTCCTGTCTTTCCCGTCCATCACCCATCCTAAGCACT
TACGTGAGTAAATAATGCAGCTCAGATGCTGAGCTCTAGTAGGAAATGCTGGCATGCTGATTACAAGATACAGCTGAGCAATGCACACAT
TTTCAGCTGGGAGTTTCTGTTCTCTGGCAAATTCTTCACTGAGTCTGGAACAATAATACCCTATGATTAGAACTGGGGAAACAGAACTGA
ATTGCTGTGTTATATGAGGAATTAAAACCTTCAAATCTCTATTTCCCCCAAATACTGACCCATTCTGGACTTTTGTAAACATACCTAGGC
CCCTGTTCCCCTGAGAGGGTGCTAAGAGGAAGGATGAAGGGCTTCAGGCTGGGGGCAGTGGACAGGGAATTGGGATACCTGGATTCTGGT
TCTGACAGGGCCACAAGCTAGGATCTCTAACAAACGCAGAAGGCTTTGGCTCGTCATTTCCTCTTAAAAAGGAGGAGCTGGGCTTCAGCT
CTAAGAACTTCATTGCCCTGGGGATCAGACAGCCCCTACCTACCCCTGCCCACTCCTCTGGAGACTGAGCCTTGCCCGTGCATATTTAGG
TCATTTCCCACACTGTCTTAGAGAACTTGTCACCAGAAACCACATGTATTTGCATGTTTTTTGTTAATTTAGCTAAAGCAATTGAATGTA

>In-frame_ENST00000372413_ENST00000420304_TCGA-BH-A18J-01A_PTPRF_chr1_44019612_+_LEFTY2_chr1_226127702_length(amino acids)=385AA_start in transcript=16_stop in transcript=1173
MWLAVELEPWMAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEV
IEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEVAGRFLASEAALHRHGRLSPRSAQARVTVEWLRVRDDGSNRTS
LIDSRLVSVHESGWKAFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPLASGAHKLVRFASQGAPAGLGEPQLELHTLDLRDYGAQGDC
DPEAPMTEGTRCCRQEMYIDLQGMKWAKNWVLEPPGFLAYECVGTCQQPPEALAFNWPFLGPRQCIASETASLPMIVSIKEGGRTRPQVV

--------------------------------------------------------------
>In-frame_ENST00000372413_ENST00000366820_TCGA-BH-A18J-01A_PTPRF_chr1_44019612_+_LEFTY2_chr1_226127702_length(transcript)=2113nt_BP=425nt
GGTTGATTGTCCTGGGCTGTGGCTGGCTGTGGAGCTAGAGCCCTGGATGGCCCCTGAGCCAGCCCCAGGGAGGACGATGGTGCCCCTTGT
GCCTGCACTGGTGATGCTTGGTTTGGTGGCAGGCGCCCATGGTGACAGCAAACCTGTCTTCATTAAAGTCCCTGAGGACCAGACTGGGCT
GTCAGGAGGGGTAGCCTCCTTCGTGTGCCAAGCTACAGGAGAACCCAAGCCGCGCATCACATGGATGAAGAAGGGGAAGAAAGTCAGCTC
CCAGCGCTTCGAGGTCATTGAGTTTGATGATGGGGCAGGGTCAGTGCTTCGGATCCAGCCATTGCGGGTGCAGCGAGATGAAGCCATCTA
TGAGTGTACAGCTACTAACAGCCTGGGTGAGATCAACACTAGTGCCAAGCTCTCAGTGCTCGAAGAGGTGGCCGGCAGGTTCCTGGCGTC
GGAGGCCAGCACACACCTGCTGGTGTTCGGCATGGAGCAGCGGCTGCCGCCCAACAGCGAGCTGGTGCAGGCCGTGCTGCGGCTCTTCCA
GGAGCCGGTCCCCAAGGCCGCGCTGCACAGGCACGGGCGGCTGTCCCCGCGCAGCGCCCAGGCCCGGGTGACCGTCGAGTGGCTGCGCGT
CCGCGACGACGGCTCCAACCGCACCTCCCTCATCGACTCCAGGCTGGTGTCCGTCCACGAGAGCGGCTGGAAGGCCTTCGACGTGACCGA
GGCCGTGAACTTCTGGCAGCAGCTGAGCCGGCCCCGGCAGCCGCTGCTGCTACAGGTGTCGGTGCAGAGGGAGCATCTGGGCCCGCTGGC
GTCCGGCGCCCACAAGCTGGTCCGCTTTGCCTCGCAGGGGGCGCCAGCCGGGCTTGGGGAGCCCCAGCTGGAGCTGCACACCCTGGACCT
CAGGGACTATGGAGCTCAGGGCGACTGTGACCCTGAAGCACCAATGACCGAGGGCACCCGCTGCTGCCGCCAGGAGATGTACATTGACCT
GCAGGGGATGAAGTGGGCCAAGAACTGGGTGCTGGAGCCCCCGGGCTTCCTGGCTTACGAGTGTGTGGGCACCTGCCAGCAGCCCCCGGA
GGCCCTGGCCTTCAATTGGCCATTTCTGGGGCCGCGACAGTGTATCGCCTCGGAGACTGCCTCGCTGCCCATGATCGTCAGCATCAAGGA
GGGAGGCAGGACCAGGCCCCAGGTGGTCAGCCTGCCCAACATGAGGGTGCAGAAGTGCAGCTGTGCCTCGGATGGGGCGCTCGTGCCAAG
GAGGCTCCAGCCATAGGCGCCTGGTGTATCCATTGAGCCCTCTAACTGAACGTGTGCATAGAGGTGGTCTTAATGTAGGTCTTAACTTTA
TACTTAGCAAGTTACTCCATCCCAATTTAGTGCTCCTGTGTGACCTTCGCCCTGTGTCCTTCCATTTCCTGTCTTTCCCGTCCATCACCC
ATCCTAAGCACTTACGTGAGTAAATAATGCAGCTCAGATGCTGAGCTCTAGTAGGAAATGCTGGCATGCTGATTACAAGATACAGCTGAG
CAATGCACACATTTTCAGCTGGGAGTTTCTGTTCTCTGGCAAATTCTTCACTGAGTCTGGAACAATAATACCCTATGATTAGAACTGGGG
AAACAGAACTGAATTGCTGTGTTATATGAGGAATTAAAACCTTCAAATCTCTATTTCCCCCAAATACTGACCCATTCTGGACTTTTGTAA
ACATACCTAGGCCCCTGTTCCCCTGAGAGGGTGCTAAGAGGAAGGATGAAGGGCTTCAGGCTGGGGGCAGTGGACAGGGAATTGGGATAC
CTGGATTCTGGTTCTGACAGGGCCACAAGCTAGGATCTCTAACAAACGCAGAAGGCTTTGGCTCGTCATTTCCTCTTAAAAAGGAGGAGC
TGGGCTTCAGCTCTAAGAACTTCATTGCCCTGGGGATCAGACAGCCCCTACCTACCCCTGCCCACTCCTCTGGAGACTGAGCCTTGCCCG
TGCATATTTAGGTCATTTCCCACACTGTCTTAGAGAACTTGTCACCAGAAACCACATGTATTTGCATGTTTTTTGTTAATTTAGCTAAAG

>In-frame_ENST00000372413_ENST00000366820_TCGA-BH-A18J-01A_PTPRF_chr1_44019612_+_LEFTY2_chr1_226127702_length(amino acids)=419AA_start in transcript=16_stop in transcript=1275
MWLAVELEPWMAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEV
IEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEVAGRFLASEASTHLLVFGMEQRLPPNSELVQAVLRLFQEPVPK
AALHRHGRLSPRSAQARVTVEWLRVRDDGSNRTSLIDSRLVSVHESGWKAFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPLASGAHK
LVRFASQGAPAGLGEPQLELHTLDLRDYGAQGDCDPEAPMTEGTRCCRQEMYIDLQGMKWAKNWVLEPPGFLAYECVGTCQQPPEALAFN

--------------------------------------------------------------
>In-frame_ENST00000372414_ENST00000420304_TCGA-BH-A18J-01A_PTPRF_chr1_44019612_+_LEFTY2_chr1_226127702_length(transcript)=2017nt_BP=425nt
GGTTGATTGTCCTGGGCTGTGGCTGGCTGTGGAGCTAGAGCCCTGGATGGCCCCTGAGCCAGCCCCAGGGAGGACGATGGTGCCCCTTGT
GCCTGCACTGGTGATGCTTGGTTTGGTGGCAGGCGCCCATGGTGACAGCAAACCTGTCTTCATTAAAGTCCCTGAGGACCAGACTGGGCT
GTCAGGAGGGGTAGCCTCCTTCGTGTGCCAAGCTACAGGAGAACCCAAGCCGCGCATCACATGGATGAAGAAGGGGAAGAAAGTCAGCTC
CCAGCGCTTCGAGGTCATTGAGTTTGATGATGGGGCAGGGTCAGTGCTTCGGATCCAGCCATTGCGGGTGCAGCGAGATGAAGCCATCTA
TGAGTGTACAGCTACTAACAGCCTGGGTGAGATCAACACTAGTGCCAAGCTCTCAGTGCTCGAAGAGGTGGCCGGCAGGTTCCTGGCGTC
GGAGGCCGCGCTGCACAGGCACGGGCGGCTGTCCCCGCGCAGCGCCCAGGCCCGGGTGACCGTCGAGTGGCTGCGCGTCCGCGACGACGG
CTCCAACCGCACCTCCCTCATCGACTCCAGGCTGGTGTCCGTCCACGAGAGCGGCTGGAAGGCCTTCGACGTGACCGAGGCCGTGAACTT
CTGGCAGCAGCTGAGCCGGCCCCGGCAGCCGCTGCTGCTACAGGTGTCGGTGCAGAGGGAGCATCTGGGCCCGCTGGCGTCCGGCGCCCA
CAAGCTGGTCCGCTTTGCCTCGCAGGGGGCGCCAGCCGGGCTTGGGGAGCCCCAGCTGGAGCTGCACACCCTGGACCTCAGGGACTATGG
AGCTCAGGGCGACTGTGACCCTGAAGCACCAATGACCGAGGGCACCCGCTGCTGCCGCCAGGAGATGTACATTGACCTGCAGGGGATGAA
GTGGGCCAAGAACTGGGTGCTGGAGCCCCCGGGCTTCCTGGCTTACGAGTGTGTGGGCACCTGCCAGCAGCCCCCGGAGGCCCTGGCCTT
CAATTGGCCATTTCTGGGGCCGCGACAGTGTATCGCCTCGGAGACTGCCTCGCTGCCCATGATCGTCAGCATCAAGGAGGGAGGCAGGAC
CAGGCCCCAGGTGGTCAGCCTGCCCAACATGAGGGTGCAGAAGTGCAGCTGTGCCTCGGATGGGGCGCTCGTGCCAAGGAGGCTCCAGCC
ATAGGCGCCTGGTGTATCCATTGAGCCCTCTAACTGAACGTGTGCATAGAGGTGGTCTTAATGTAGGTCTTAACTTTATACTTAGCAAGT
TACTCCATCCCAATTTAGTGCTCCTGTGTGACCTTCGCCCTGTGTCCTTCCATTTCCTGTCTTTCCCGTCCATCACCCATCCTAAGCACT
TACGTGAGTAAATAATGCAGCTCAGATGCTGAGCTCTAGTAGGAAATGCTGGCATGCTGATTACAAGATACAGCTGAGCAATGCACACAT
TTTCAGCTGGGAGTTTCTGTTCTCTGGCAAATTCTTCACTGAGTCTGGAACAATAATACCCTATGATTAGAACTGGGGAAACAGAACTGA
ATTGCTGTGTTATATGAGGAATTAAAACCTTCAAATCTCTATTTCCCCCAAATACTGACCCATTCTGGACTTTTGTAAACATACCTAGGC
CCCTGTTCCCCTGAGAGGGTGCTAAGAGGAAGGATGAAGGGCTTCAGGCTGGGGGCAGTGGACAGGGAATTGGGATACCTGGATTCTGGT
TCTGACAGGGCCACAAGCTAGGATCTCTAACAAACGCAGAAGGCTTTGGCTCGTCATTTCCTCTTAAAAAGGAGGAGCTGGGCTTCAGCT
CTAAGAACTTCATTGCCCTGGGGATCAGACAGCCCCTACCTACCCCTGCCCACTCCTCTGGAGACTGAGCCTTGCCCGTGCATATTTAGG
TCATTTCCCACACTGTCTTAGAGAACTTGTCACCAGAAACCACATGTATTTGCATGTTTTTTGTTAATTTAGCTAAAGCAATTGAATGTA

>In-frame_ENST00000372414_ENST00000420304_TCGA-BH-A18J-01A_PTPRF_chr1_44019612_+_LEFTY2_chr1_226127702_length(amino acids)=385AA_start in transcript=16_stop in transcript=1173
MWLAVELEPWMAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEV
IEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEVAGRFLASEAALHRHGRLSPRSAQARVTVEWLRVRDDGSNRTS
LIDSRLVSVHESGWKAFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPLASGAHKLVRFASQGAPAGLGEPQLELHTLDLRDYGAQGDC
DPEAPMTEGTRCCRQEMYIDLQGMKWAKNWVLEPPGFLAYECVGTCQQPPEALAFNWPFLGPRQCIASETASLPMIVSIKEGGRTRPQVV

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>In-frame_ENST00000372414_ENST00000366820_TCGA-BH-A18J-01A_PTPRF_chr1_44019612_+_LEFTY2_chr1_226127702_length(transcript)=2113nt_BP=425nt
GGTTGATTGTCCTGGGCTGTGGCTGGCTGTGGAGCTAGAGCCCTGGATGGCCCCTGAGCCAGCCCCAGGGAGGACGATGGTGCCCCTTGT
GCCTGCACTGGTGATGCTTGGTTTGGTGGCAGGCGCCCATGGTGACAGCAAACCTGTCTTCATTAAAGTCCCTGAGGACCAGACTGGGCT
GTCAGGAGGGGTAGCCTCCTTCGTGTGCCAAGCTACAGGAGAACCCAAGCCGCGCATCACATGGATGAAGAAGGGGAAGAAAGTCAGCTC
CCAGCGCTTCGAGGTCATTGAGTTTGATGATGGGGCAGGGTCAGTGCTTCGGATCCAGCCATTGCGGGTGCAGCGAGATGAAGCCATCTA
TGAGTGTACAGCTACTAACAGCCTGGGTGAGATCAACACTAGTGCCAAGCTCTCAGTGCTCGAAGAGGTGGCCGGCAGGTTCCTGGCGTC
GGAGGCCAGCACACACCTGCTGGTGTTCGGCATGGAGCAGCGGCTGCCGCCCAACAGCGAGCTGGTGCAGGCCGTGCTGCGGCTCTTCCA
GGAGCCGGTCCCCAAGGCCGCGCTGCACAGGCACGGGCGGCTGTCCCCGCGCAGCGCCCAGGCCCGGGTGACCGTCGAGTGGCTGCGCGT
CCGCGACGACGGCTCCAACCGCACCTCCCTCATCGACTCCAGGCTGGTGTCCGTCCACGAGAGCGGCTGGAAGGCCTTCGACGTGACCGA
GGCCGTGAACTTCTGGCAGCAGCTGAGCCGGCCCCGGCAGCCGCTGCTGCTACAGGTGTCGGTGCAGAGGGAGCATCTGGGCCCGCTGGC
GTCCGGCGCCCACAAGCTGGTCCGCTTTGCCTCGCAGGGGGCGCCAGCCGGGCTTGGGGAGCCCCAGCTGGAGCTGCACACCCTGGACCT
CAGGGACTATGGAGCTCAGGGCGACTGTGACCCTGAAGCACCAATGACCGAGGGCACCCGCTGCTGCCGCCAGGAGATGTACATTGACCT
GCAGGGGATGAAGTGGGCCAAGAACTGGGTGCTGGAGCCCCCGGGCTTCCTGGCTTACGAGTGTGTGGGCACCTGCCAGCAGCCCCCGGA
GGCCCTGGCCTTCAATTGGCCATTTCTGGGGCCGCGACAGTGTATCGCCTCGGAGACTGCCTCGCTGCCCATGATCGTCAGCATCAAGGA
GGGAGGCAGGACCAGGCCCCAGGTGGTCAGCCTGCCCAACATGAGGGTGCAGAAGTGCAGCTGTGCCTCGGATGGGGCGCTCGTGCCAAG
GAGGCTCCAGCCATAGGCGCCTGGTGTATCCATTGAGCCCTCTAACTGAACGTGTGCATAGAGGTGGTCTTAATGTAGGTCTTAACTTTA
TACTTAGCAAGTTACTCCATCCCAATTTAGTGCTCCTGTGTGACCTTCGCCCTGTGTCCTTCCATTTCCTGTCTTTCCCGTCCATCACCC
ATCCTAAGCACTTACGTGAGTAAATAATGCAGCTCAGATGCTGAGCTCTAGTAGGAAATGCTGGCATGCTGATTACAAGATACAGCTGAG
CAATGCACACATTTTCAGCTGGGAGTTTCTGTTCTCTGGCAAATTCTTCACTGAGTCTGGAACAATAATACCCTATGATTAGAACTGGGG
AAACAGAACTGAATTGCTGTGTTATATGAGGAATTAAAACCTTCAAATCTCTATTTCCCCCAAATACTGACCCATTCTGGACTTTTGTAA
ACATACCTAGGCCCCTGTTCCCCTGAGAGGGTGCTAAGAGGAAGGATGAAGGGCTTCAGGCTGGGGGCAGTGGACAGGGAATTGGGATAC
CTGGATTCTGGTTCTGACAGGGCCACAAGCTAGGATCTCTAACAAACGCAGAAGGCTTTGGCTCGTCATTTCCTCTTAAAAAGGAGGAGC
TGGGCTTCAGCTCTAAGAACTTCATTGCCCTGGGGATCAGACAGCCCCTACCTACCCCTGCCCACTCCTCTGGAGACTGAGCCTTGCCCG
TGCATATTTAGGTCATTTCCCACACTGTCTTAGAGAACTTGTCACCAGAAACCACATGTATTTGCATGTTTTTTGTTAATTTAGCTAAAG

>In-frame_ENST00000372414_ENST00000366820_TCGA-BH-A18J-01A_PTPRF_chr1_44019612_+_LEFTY2_chr1_226127702_length(amino acids)=419AA_start in transcript=16_stop in transcript=1275
MWLAVELEPWMAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEV
IEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEVAGRFLASEASTHLLVFGMEQRLPPNSELVQAVLRLFQEPVPK
AALHRHGRLSPRSAQARVTVEWLRVRDDGSNRTSLIDSRLVSVHESGWKAFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPLASGAHK
LVRFASQGAPAGLGEPQLELHTLDLRDYGAQGDCDPEAPMTEGTRCCRQEMYIDLQGMKWAKNWVLEPPGFLAYECVGTCQQPPEALAFN

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Fusion Gene PPI Analysis for PTPRF-LEFTY2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PTPRF-LEFTY2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTPRF-LEFTY2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTPRFC0024623Malignant neoplasm of stomach1CTD_human
HgenePTPRFC0038356Stomach Neoplasms1CTD_human
HgenePTPRFC0175755Congenital absent nipple1GENOMICS_ENGLAND
HgenePTPRFC0235874Disease Exacerbation1CTD_human
HgenePTPRFC0345967Malignant mesothelioma1CTD_human
HgenePTPRFC0432357Congenital absence of breast with absent nipple1ORPHANET
HgenePTPRFC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneLEFTY2C0000772Multiple congenital anomalies1CTD_human
TgeneLEFTY2C0175707Asplenia Syndrome1CTD_human
TgeneLEFTY2C0265357Polysplenia Syndrome1CTD_human
TgeneLEFTY2C0266642Situs ambiguus1CTD_human;ORPHANET
TgeneLEFTY2C3178805Heterotaxy Syndrome1CTD_human;GENOMICS_ENGLAND
TgeneLEFTY2C3178806Right Atrial Isomerism1CTD_human
TgeneLEFTY2C3178807Left Atrial Isomerism1CTD_human