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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PTPRF-PSMD3 (FusionGDB2 ID:69949)

Fusion Gene Summary for PTPRF-PSMD3

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRF-PSMD3
Fusion gene ID: 69949
HgeneTgene
Gene symbol

PTPRF

PSMD3

Gene ID

5792

5709

Gene nameprotein tyrosine phosphatase receptor type Fproteasome 26S subunit, non-ATPase 3
SynonymsBNAH2|LARP58|RPN3|S3|TSTA2
Cytomap

1p34.2

17q21.1

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase FLCA-homologleukocyte antigen-related (LAR) PTP receptorleukocyte antigen-related tyrosine phosphataseleukocyte common antigen relatedprotein tyrosine phosphatase, receptor type, F polypeptidereceptor-linke26S proteasome non-ATPase regulatory subunit 326S proteasome regulatory subunit RPN326S proteasome regulatory subunit S3proteasome (prosome, macropain) 26S subunit, non-ATPase, 3proteasome subunit p58tissue specific transplantation antigen 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000359947, ENST00000438120, 
ENST00000372413, ENST00000372414, 
ENST00000422171, ENST00000496447, 
ENST00000264639, ENST00000541736, 
Fusion gene scores* DoF score22 X 15 X 12=396016 X 18 X 8=2304
# samples 2421
** MAII scorelog2(24/3960*10)=-4.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/2304*10)=-3.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPRF [Title/Abstract] AND PSMD3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPTPRF(44054671)-PSMD3(38146346), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPRF

GO:0099560

synaptic membrane adhesion

26321637


check buttonFusion gene breakpoints across PTPRF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PSMD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-FP-A8CXPTPRFchr1

44054671

+PSMD3chr17

38146346

+
ChimerDB4STADTCGA-FP-A8CXPTPRFchr1

44054671

+PSMD3chr17

38146346

+


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Fusion Gene ORF analysis for PTPRF-PSMD3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000359947ENST00000264639PTPRFchr1

44054671

+PSMD3chr17

38146346

+
In-frameENST00000359947ENST00000541736PTPRFchr1

44054671

+PSMD3chr17

38146346

+
In-frameENST00000438120ENST00000264639PTPRFchr1

44054671

+PSMD3chr17

38146346

+
In-frameENST00000438120ENST00000541736PTPRFchr1

44054671

+PSMD3chr17

38146346

+
In-frameENST00000372413ENST00000264639PTPRFchr1

44054671

+PSMD3chr17

38146346

+
In-frameENST00000372413ENST00000541736PTPRFchr1

44054671

+PSMD3chr17

38146346

+
In-frameENST00000372414ENST00000264639PTPRFchr1

44054671

+PSMD3chr17

38146346

+
In-frameENST00000372414ENST00000541736PTPRFchr1

44054671

+PSMD3chr17

38146346

+
intron-3CDSENST00000422171ENST00000264639PTPRFchr1

44054671

+PSMD3chr17

38146346

+
intron-3CDSENST00000422171ENST00000541736PTPRFchr1

44054671

+PSMD3chr17

38146346

+
intron-3CDSENST00000496447ENST00000264639PTPRFchr1

44054671

+PSMD3chr17

38146346

+
intron-3CDSENST00000496447ENST00000541736PTPRFchr1

44054671

+PSMD3chr17

38146346

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000359947PTPRFchr144054671+ENST00000264639PSMD3chr1738146346+239612893102016568
ENST00000359947PTPRFchr144054671+ENST00000541736PSMD3chr1738146346+214012893101896528
ENST00000438120PTPRFchr144054671+ENST00000264639PSMD3chr1738146346+238212752962002568
ENST00000438120PTPRFchr144054671+ENST00000541736PSMD3chr1738146346+212612752961882528
ENST00000372413PTPRFchr144054671+ENST00000264639PSMD3chr1738146346+2102995161722568
ENST00000372413PTPRFchr144054671+ENST00000541736PSMD3chr1738146346+1846995161602528
ENST00000372414PTPRFchr144054671+ENST00000264639PSMD3chr1738146346+2102995161722568
ENST00000372414PTPRFchr144054671+ENST00000541736PSMD3chr1738146346+1846995161602528

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000359947ENST00000264639PTPRFchr144054671+PSMD3chr1738146346+0.018363840.98163617
ENST00000359947ENST00000541736PTPRFchr144054671+PSMD3chr1738146346+0.0167747510.9832252
ENST00000438120ENST00000264639PTPRFchr144054671+PSMD3chr1738146346+0.0180666740.9819333
ENST00000438120ENST00000541736PTPRFchr144054671+PSMD3chr1738146346+0.0162316360.9837684
ENST00000372413ENST00000264639PTPRFchr144054671+PSMD3chr1738146346+0.0139411450.9860589
ENST00000372413ENST00000541736PTPRFchr144054671+PSMD3chr1738146346+0.0141544890.98584557
ENST00000372414ENST00000264639PTPRFchr144054671+PSMD3chr1738146346+0.0139411450.9860589
ENST00000372414ENST00000541736PTPRFchr144054671+PSMD3chr1738146346+0.0141544890.98584557

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Fusion Genomic Features for PTPRF-PSMD3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PTPRFchr144054671+PSMD3chr1738146346+0.0008542450.99914575
PTPRFchr144054671+PSMD3chr1738146346+0.0008542450.99914575

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PTPRF-PSMD3


check button Go to

FGviewer for the breakpoints of chr1:44054671-chr17:38146346

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPRFchr1:44054671chr17:38146346ENST00000359947+834135_224316.33333333333331908.0DomainNote=Ig-like C2-type 2
HgenePTPRFchr1:44054671chr17:38146346ENST00000359947+834232_314316.33333333333331908.0DomainNote=Ig-like C2-type 3
HgenePTPRFchr1:44054671chr17:38146346ENST00000359947+83433_123316.33333333333331908.0DomainNote=Ig-like C2-type 1
HgenePTPRFchr1:44054671chr17:38146346ENST00000372413+631135_224316.33333333333331899.0DomainNote=Ig-like C2-type 2
HgenePTPRFchr1:44054671chr17:38146346ENST00000372413+631232_314316.33333333333331899.0DomainNote=Ig-like C2-type 3
HgenePTPRFchr1:44054671chr17:38146346ENST00000372413+63133_123316.33333333333331899.0DomainNote=Ig-like C2-type 1
HgenePTPRFchr1:44054671chr17:38146346ENST00000372414+632135_224316.33333333333331908.0DomainNote=Ig-like C2-type 2
HgenePTPRFchr1:44054671chr17:38146346ENST00000372414+632232_314316.33333333333331908.0DomainNote=Ig-like C2-type 3
HgenePTPRFchr1:44054671chr17:38146346ENST00000372414+63233_123316.33333333333331908.0DomainNote=Ig-like C2-type 1
HgenePTPRFchr1:44054671chr17:38146346ENST00000438120+833135_224316.33333333333331899.0DomainNote=Ig-like C2-type 2
HgenePTPRFchr1:44054671chr17:38146346ENST00000438120+833232_314316.33333333333331899.0DomainNote=Ig-like C2-type 3
HgenePTPRFchr1:44054671chr17:38146346ENST00000438120+83333_123316.33333333333331899.0DomainNote=Ig-like C2-type 1
HgenePTPRFchr1:44054671chr17:38146346ENST00000359947+83468_77316.33333333333331908.0RegionHeparin-binding
HgenePTPRFchr1:44054671chr17:38146346ENST00000372413+63168_77316.33333333333331899.0RegionHeparin-binding
HgenePTPRFchr1:44054671chr17:38146346ENST00000372414+63268_77316.33333333333331908.0RegionHeparin-binding
HgenePTPRFchr1:44054671chr17:38146346ENST00000438120+83368_77316.33333333333331899.0RegionHeparin-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPRFchr1:44054671chr17:38146346ENST00000359947+8341014_1098316.33333333333331908.0DomainFibronectin type-III 8
HgenePTPRFchr1:44054671chr17:38146346ENST00000359947+8341352_1607316.33333333333331908.0DomainTyrosine-protein phosphatase 1
HgenePTPRFchr1:44054671chr17:38146346ENST00000359947+8341639_1898316.33333333333331908.0DomainTyrosine-protein phosphatase 2
HgenePTPRFchr1:44054671chr17:38146346ENST00000359947+834321_411316.33333333333331908.0DomainFibronectin type-III 1
HgenePTPRFchr1:44054671chr17:38146346ENST00000359947+834416_510316.33333333333331908.0DomainFibronectin type-III 2
HgenePTPRFchr1:44054671chr17:38146346ENST00000359947+834514_604316.33333333333331908.0DomainFibronectin type-III 3
HgenePTPRFchr1:44054671chr17:38146346ENST00000359947+834609_706316.33333333333331908.0DomainFibronectin type-III 4
HgenePTPRFchr1:44054671chr17:38146346ENST00000359947+834711_819316.33333333333331908.0DomainFibronectin type-III 5
HgenePTPRFchr1:44054671chr17:38146346ENST00000359947+834820_914316.33333333333331908.0DomainFibronectin type-III 6
HgenePTPRFchr1:44054671chr17:38146346ENST00000359947+834918_1010316.33333333333331908.0DomainFibronectin type-III 7
HgenePTPRFchr1:44054671chr17:38146346ENST00000372413+6311014_1098316.33333333333331899.0DomainFibronectin type-III 8
HgenePTPRFchr1:44054671chr17:38146346ENST00000372413+6311352_1607316.33333333333331899.0DomainTyrosine-protein phosphatase 1
HgenePTPRFchr1:44054671chr17:38146346ENST00000372413+6311639_1898316.33333333333331899.0DomainTyrosine-protein phosphatase 2
HgenePTPRFchr1:44054671chr17:38146346ENST00000372413+631321_411316.33333333333331899.0DomainFibronectin type-III 1
HgenePTPRFchr1:44054671chr17:38146346ENST00000372413+631416_510316.33333333333331899.0DomainFibronectin type-III 2
HgenePTPRFchr1:44054671chr17:38146346ENST00000372413+631514_604316.33333333333331899.0DomainFibronectin type-III 3
HgenePTPRFchr1:44054671chr17:38146346ENST00000372413+631609_706316.33333333333331899.0DomainFibronectin type-III 4
HgenePTPRFchr1:44054671chr17:38146346ENST00000372413+631711_819316.33333333333331899.0DomainFibronectin type-III 5
HgenePTPRFchr1:44054671chr17:38146346ENST00000372413+631820_914316.33333333333331899.0DomainFibronectin type-III 6
HgenePTPRFchr1:44054671chr17:38146346ENST00000372413+631918_1010316.33333333333331899.0DomainFibronectin type-III 7
HgenePTPRFchr1:44054671chr17:38146346ENST00000372414+6321014_1098316.33333333333331908.0DomainFibronectin type-III 8
HgenePTPRFchr1:44054671chr17:38146346ENST00000372414+6321352_1607316.33333333333331908.0DomainTyrosine-protein phosphatase 1
HgenePTPRFchr1:44054671chr17:38146346ENST00000372414+6321639_1898316.33333333333331908.0DomainTyrosine-protein phosphatase 2
HgenePTPRFchr1:44054671chr17:38146346ENST00000372414+632321_411316.33333333333331908.0DomainFibronectin type-III 1
HgenePTPRFchr1:44054671chr17:38146346ENST00000372414+632416_510316.33333333333331908.0DomainFibronectin type-III 2
HgenePTPRFchr1:44054671chr17:38146346ENST00000372414+632514_604316.33333333333331908.0DomainFibronectin type-III 3
HgenePTPRFchr1:44054671chr17:38146346ENST00000372414+632609_706316.33333333333331908.0DomainFibronectin type-III 4
HgenePTPRFchr1:44054671chr17:38146346ENST00000372414+632711_819316.33333333333331908.0DomainFibronectin type-III 5
HgenePTPRFchr1:44054671chr17:38146346ENST00000372414+632820_914316.33333333333331908.0DomainFibronectin type-III 6
HgenePTPRFchr1:44054671chr17:38146346ENST00000372414+632918_1010316.33333333333331908.0DomainFibronectin type-III 7
HgenePTPRFchr1:44054671chr17:38146346ENST00000438120+8331014_1098316.33333333333331899.0DomainFibronectin type-III 8
HgenePTPRFchr1:44054671chr17:38146346ENST00000438120+8331352_1607316.33333333333331899.0DomainTyrosine-protein phosphatase 1
HgenePTPRFchr1:44054671chr17:38146346ENST00000438120+8331639_1898316.33333333333331899.0DomainTyrosine-protein phosphatase 2
HgenePTPRFchr1:44054671chr17:38146346ENST00000438120+833321_411316.33333333333331899.0DomainFibronectin type-III 1
HgenePTPRFchr1:44054671chr17:38146346ENST00000438120+833416_510316.33333333333331899.0DomainFibronectin type-III 2
HgenePTPRFchr1:44054671chr17:38146346ENST00000438120+833514_604316.33333333333331899.0DomainFibronectin type-III 3
HgenePTPRFchr1:44054671chr17:38146346ENST00000438120+833609_706316.33333333333331899.0DomainFibronectin type-III 4
HgenePTPRFchr1:44054671chr17:38146346ENST00000438120+833711_819316.33333333333331899.0DomainFibronectin type-III 5
HgenePTPRFchr1:44054671chr17:38146346ENST00000438120+833820_914316.33333333333331899.0DomainFibronectin type-III 6
HgenePTPRFchr1:44054671chr17:38146346ENST00000438120+833918_1010316.33333333333331899.0DomainFibronectin type-III 7
HgenePTPRFchr1:44054671chr17:38146346ENST00000359947+8341548_1554316.33333333333331908.0RegionSubstrate binding
HgenePTPRFchr1:44054671chr17:38146346ENST00000372413+6311548_1554316.33333333333331899.0RegionSubstrate binding
HgenePTPRFchr1:44054671chr17:38146346ENST00000372414+6321548_1554316.33333333333331908.0RegionSubstrate binding
HgenePTPRFchr1:44054671chr17:38146346ENST00000438120+8331548_1554316.33333333333331899.0RegionSubstrate binding
HgenePTPRFchr1:44054671chr17:38146346ENST00000359947+8341285_1907316.33333333333331908.0Topological domainCytoplasmic
HgenePTPRFchr1:44054671chr17:38146346ENST00000359947+83430_1263316.33333333333331908.0Topological domainExtracellular
HgenePTPRFchr1:44054671chr17:38146346ENST00000372413+6311285_1907316.33333333333331899.0Topological domainCytoplasmic
HgenePTPRFchr1:44054671chr17:38146346ENST00000372413+63130_1263316.33333333333331899.0Topological domainExtracellular
HgenePTPRFchr1:44054671chr17:38146346ENST00000372414+6321285_1907316.33333333333331908.0Topological domainCytoplasmic
HgenePTPRFchr1:44054671chr17:38146346ENST00000372414+63230_1263316.33333333333331908.0Topological domainExtracellular
HgenePTPRFchr1:44054671chr17:38146346ENST00000438120+8331285_1907316.33333333333331899.0Topological domainCytoplasmic
HgenePTPRFchr1:44054671chr17:38146346ENST00000438120+83330_1263316.33333333333331899.0Topological domainExtracellular
HgenePTPRFchr1:44054671chr17:38146346ENST00000359947+8341264_1284316.33333333333331908.0TransmembraneHelical
HgenePTPRFchr1:44054671chr17:38146346ENST00000372413+6311264_1284316.33333333333331899.0TransmembraneHelical
HgenePTPRFchr1:44054671chr17:38146346ENST00000372414+6321264_1284316.33333333333331908.0TransmembraneHelical
HgenePTPRFchr1:44054671chr17:38146346ENST00000438120+8331264_1284316.33333333333331899.0TransmembraneHelical
TgenePSMD3chr1:44054671chr17:38146346ENST0000026463941226_32292.3333333333333535.0Compositional biasNote=Poly-Pro
TgenePSMD3chr1:44054671chr17:38146346ENST00000264639412286_465292.3333333333333535.0DomainPCI


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Fusion Gene Sequence for PTPRF-PSMD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000359947_ENST00000264639_TCGA-FP-A8CX_PTPRF_chr1_44054671_+_PSMD3_chr17_38146346_length(transcript)=2396nt_BP=1289nt
CGGGAGCGGCGGGAGCGGTGGCGGCGGCAGAGGCGGCGGCTCCAGCTTCGGCTCCGGCTCGGGCTCGGGCTCCGGCTCCGGCTCCGGCTC
CGGCTCCAGCTCGGGTGGCGGTGGCGGGAGCGGGACCAGGTGGAGGCGGCGGCGGCAGAGGAGTGGGAGCAGCGGCCCTAGCGGCTTGCG
GGGGGACATGCGGACCGACGGCCCCTGGATAGGCGGAAGGAGTGGAGGCCCTGGTGCCCGGCCCTTGGTGCTGAGTATCCAGCAAGAGTG
ACCGGGGTGAAGAAGCAAAGACTCGGTTGATTGTCCTGGGCTGTGGCTGGCTGTGGAGCTAGAGCCCTGGATGGCCCCTGAGCCAGCCCC
AGGGAGGACGATGGTGCCCCTTGTGCCTGCACTGGTGATGCTTGGTTTGGTGGCAGGCGCCCATGGTGACAGCAAACCTGTCTTCATTAA
AGTCCCTGAGGACCAGACTGGGCTGTCAGGAGGGGTAGCCTCCTTCGTGTGCCAAGCTACAGGAGAACCCAAGCCGCGCATCACATGGAT
GAAGAAGGGGAAGAAAGTCAGCTCCCAGCGCTTCGAGGTCATTGAGTTTGATGATGGGGCAGGGTCAGTGCTTCGGATCCAGCCATTGCG
GGTGCAGCGAGATGAAGCCATCTATGAGTGTACAGCTACTAACAGCCTGGGTGAGATCAACACTAGTGCCAAGCTCTCAGTGCTCGAAGA
GGAACAGCTGCCCCCTGGGTTCCCTTCCATCGACATGGGGCCTCAGCTGAAGGTGGTGGAGAAGGCACGCACAGCCACCATGCTATGTGC
CGCAGGCGGAAATCCAGACCCTGAGATTTCTTGGTTCAAGGACTTCCTTCCTGTAGACCCTGCCACGAGCAACGGCCGCATCAAGCAGCT
GCGTTCAGGTGCCTTGCAGATAGAGAGCAGTGAGGAATCCGACCAAGGCAAGTACGAGTGTGTGGCGACCAACTCGGCAGGCACACGTTA
CTCAGCCCCTGCGAACCTGTATGTGCGAGTGCGCCGCGTGGCTCCTCGTTTCTCCATCCCTCCCAGCAGCCAGGAGGTGATGCCAGGCGG
CAGCGTGAACCTGACATGCGTGGCAGTGGGTGCACCCATGCCCTACGTGAAGTGGATGATGGGGGCCGAGGAGCTCACCAAGGAGGATGA
GATGCCAGTTGGCCGCAACGTCCTGGAGCTCAGCAATGTCGTACGCTCTGCCAACTACACCTGTGTGGCCATCTCCTCGCTGGGCATGAT
CGAGGCCACAGCCCAGGTCACAGTGAAAGGGCGAATCAAAGCCATCCAGCTGGAGTACTCAGAGGCCCGGAGAACGATGACCAACGCCCT
TCGCAAGGCCCCTCAGCACACAGCTGTCGGCTTCAAACAGACGGTGCACAAGCTTCTCATCGTGGTGGAGCTGTTGCTGGGGGAGATCCC
TGACCGGCTGCAGTTCCGCCAGCCCTCCCTCAAGCGCTCACTCATGCCCTATTTCCTTCTGACTCAAGCTGTCAGGACAGGAAACCTAGC
CAAGTTCAACCAGGTCCTGGATCAGTTTGGGGAGAAGTTTCAAGCAGATGGGACCTACACCCTAATTATCCGGCTGCGGCACAACGTGAT
TAAGACAGGTGTACGCATGATCAGCCTCTCCTATTCCCGAATCTCCTTGGCTGACATCGCCCAGAAGCTGCAGTTGGATAGCCCCGAAGA
TGCAGAGTTCATTGTTGCCAAGGCCATCCGGGATGGTGTCATTGAGGCCAGCATCAACCACGAGAAGGGCTATGTCCAATCCAAGGAGAT
GATTGACATCTATTCCACCCGAGAGCCCCAGCTAGCCTTCCACCAGCGCATCTCCTTCTGCCTAGATATCCACAACATGTCTGTCAAGGC
CATGAGGTTTCCTCCCAAATCGTACAACAAGGACTTGGAGTCTGCAGAGGAACGGCGTGAGCGAGAACAGCAGGACTTGGAGTTTGCCAA
GGAGATGGCAGAAGATGATGATGACAGCTTCCCTTGAGCTGGGGGGCTGGGGAGGGGTAGGGGGAATGGGGACAGGCTCTTTCCCCCTTG
GGGGTCCCCTGCCCAGGGCACTGTCCCCATTTTCCCACACACAGCTCATATGCTGCATTCGTGCAGGGGGTGGGGGTGCTGGGAGCCAGC
CACCCTGACCTCCCCCAGGGCTCCTCCCCAGCCGGTGACTTACTGTACAGCAGGCAGGAGGGTGGGCAGGCAACCTCCCCGGGCAGGGTC
CTGGCCAGCAGTGTGGGAGCAGGAGGGGAAGGATAGTTCTGTGTACTCCTTTAGGGAGTGGGGGACTAGAACTGGGATGTCTTGGCTTGT

>In-frame_ENST00000359947_ENST00000264639_TCGA-FP-A8CX_PTPRF_chr1_44054671_+_PSMD3_chr17_38146346_length(amino acids)=568AA_start in transcript=310_stop in transcript=2016
MWLAVELEPWMAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEV
IEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFK
DFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPM
PYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKGRIKAIQLEYSEARRTMTNALRKAPQHTAVGFKQ
TVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPYFLLTQAVRTGNLAKFNQVLDQFGEKFQADGTYTLIIRLRHNVIKTGVRMISLSYSR
ISLADIAQKLQLDSPEDAEFIVAKAIRDGVIEASINHEKGYVQSKEMIDIYSTREPQLAFHQRISFCLDIHNMSVKAMRFPPKSYNKDLE

--------------------------------------------------------------
>In-frame_ENST00000359947_ENST00000541736_TCGA-FP-A8CX_PTPRF_chr1_44054671_+_PSMD3_chr17_38146346_length(transcript)=2140nt_BP=1289nt
CGGGAGCGGCGGGAGCGGTGGCGGCGGCAGAGGCGGCGGCTCCAGCTTCGGCTCCGGCTCGGGCTCGGGCTCCGGCTCCGGCTCCGGCTC
CGGCTCCAGCTCGGGTGGCGGTGGCGGGAGCGGGACCAGGTGGAGGCGGCGGCGGCAGAGGAGTGGGAGCAGCGGCCCTAGCGGCTTGCG
GGGGGACATGCGGACCGACGGCCCCTGGATAGGCGGAAGGAGTGGAGGCCCTGGTGCCCGGCCCTTGGTGCTGAGTATCCAGCAAGAGTG
ACCGGGGTGAAGAAGCAAAGACTCGGTTGATTGTCCTGGGCTGTGGCTGGCTGTGGAGCTAGAGCCCTGGATGGCCCCTGAGCCAGCCCC
AGGGAGGACGATGGTGCCCCTTGTGCCTGCACTGGTGATGCTTGGTTTGGTGGCAGGCGCCCATGGTGACAGCAAACCTGTCTTCATTAA
AGTCCCTGAGGACCAGACTGGGCTGTCAGGAGGGGTAGCCTCCTTCGTGTGCCAAGCTACAGGAGAACCCAAGCCGCGCATCACATGGAT
GAAGAAGGGGAAGAAAGTCAGCTCCCAGCGCTTCGAGGTCATTGAGTTTGATGATGGGGCAGGGTCAGTGCTTCGGATCCAGCCATTGCG
GGTGCAGCGAGATGAAGCCATCTATGAGTGTACAGCTACTAACAGCCTGGGTGAGATCAACACTAGTGCCAAGCTCTCAGTGCTCGAAGA
GGAACAGCTGCCCCCTGGGTTCCCTTCCATCGACATGGGGCCTCAGCTGAAGGTGGTGGAGAAGGCACGCACAGCCACCATGCTATGTGC
CGCAGGCGGAAATCCAGACCCTGAGATTTCTTGGTTCAAGGACTTCCTTCCTGTAGACCCTGCCACGAGCAACGGCCGCATCAAGCAGCT
GCGTTCAGGTGCCTTGCAGATAGAGAGCAGTGAGGAATCCGACCAAGGCAAGTACGAGTGTGTGGCGACCAACTCGGCAGGCACACGTTA
CTCAGCCCCTGCGAACCTGTATGTGCGAGTGCGCCGCGTGGCTCCTCGTTTCTCCATCCCTCCCAGCAGCCAGGAGGTGATGCCAGGCGG
CAGCGTGAACCTGACATGCGTGGCAGTGGGTGCACCCATGCCCTACGTGAAGTGGATGATGGGGGCCGAGGAGCTCACCAAGGAGGATGA
GATGCCAGTTGGCCGCAACGTCCTGGAGCTCAGCAATGTCGTACGCTCTGCCAACTACACCTGTGTGGCCATCTCCTCGCTGGGCATGAT
CGAGGCCACAGCCCAGGTCACAGTGAAAGGGCGAATCAAAGCCATCCAGCTGGAGTACTCAGAGGCCCGGAGAACGATGACCAACGCCCT
TCGCAAGGCCCCTCAGCACACAGCTGTCGGCTTCAAACAGACGGTGCACAAGCTTCTCATCGTGGTGGAGCTGTTGCTGGGGGAGATCCC
TGACCGGCTGCAGTTCCGCCAGCCCTCCCTCAAGCGCTCACTCATGCCCTATTTCCTTCTGACTCAAGCTGTCAGGACAGGAAACCTAGC
CAAGTTCAACCAGGTCCTGGATCAGTTTGGGGAGAAGTTTCAAGCAGATGGGACCTACACCCTAATTATCCGGCTGCGGCACAACGTGAT
TAAGACAGGTGTACGCATGATCAGCCTCTCCTATTCCCGAATCTCCTTGGCTGACATCGCCCAGAAGCTGCAGTTGGATAGCCCCGAAGA
TGCAGAGTTCATTGTTGCCAAGGCCATCCGGGATGGTGTCATTGAGGCCAGCATCAACCACGAGAAGGGCTATGTCCAATCCAAGGAGAT
GATTGACATCTATTCCACCCGAGAGCCCCAGCTAGCCTTCCACCAGCGCATCTCCTTCTGCCTAGATATCCACAACATGTCTGTCAAGGG
TTGGTAAGATTAAAAGAAGTCCCTGTATTGAGGCACTTAGCGAAGTCTAAATTGTAAAAAAGATGGCGCTGGTATCTAGCTCCACAAAAG
GGCCATGAGGTTTCCTCCCAAATCGTACAACAAGGACTTGGAGTCTGCAGAGGAACGGCGTGAGCGAGAACAGCAGGACTTGGAGTTTGC

>In-frame_ENST00000359947_ENST00000541736_TCGA-FP-A8CX_PTPRF_chr1_44054671_+_PSMD3_chr17_38146346_length(amino acids)=528AA_start in transcript=310_stop in transcript=1896
MWLAVELEPWMAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEV
IEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFK
DFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPM
PYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKGRIKAIQLEYSEARRTMTNALRKAPQHTAVGFKQ
TVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPYFLLTQAVRTGNLAKFNQVLDQFGEKFQADGTYTLIIRLRHNVIKTGVRMISLSYSR

--------------------------------------------------------------
>In-frame_ENST00000438120_ENST00000264639_TCGA-FP-A8CX_PTPRF_chr1_44054671_+_PSMD3_chr17_38146346_length(transcript)=2382nt_BP=1275nt
GCGGTGGCGGCGGCAGAGGCGGCGGCTCCAGCTTCGGCTCCGGCTCGGGCTCGGGCTCCGGCTCCGGCTCCGGCTCCGGCTCCAGCTCGG
GTGGCGGTGGCGGGAGCGGGACCAGGTGGAGGCGGCGGCGGCAGAGGAGTGGGAGCAGCGGCCCTAGCGGCTTGCGGGGGGACATGCGGA
CCGACGGCCCCTGGATAGGCGGAAGGAGTGGAGGCCCTGGTGCCCGGCCCTTGGTGCTGAGTATCCAGCAAGAGTGACCGGGGTGAAGAA
GCAAAGACTCGGTTGATTGTCCTGGGCTGTGGCTGGCTGTGGAGCTAGAGCCCTGGATGGCCCCTGAGCCAGCCCCAGGGAGGACGATGG
TGCCCCTTGTGCCTGCACTGGTGATGCTTGGTTTGGTGGCAGGCGCCCATGGTGACAGCAAACCTGTCTTCATTAAAGTCCCTGAGGACC
AGACTGGGCTGTCAGGAGGGGTAGCCTCCTTCGTGTGCCAAGCTACAGGAGAACCCAAGCCGCGCATCACATGGATGAAGAAGGGGAAGA
AAGTCAGCTCCCAGCGCTTCGAGGTCATTGAGTTTGATGATGGGGCAGGGTCAGTGCTTCGGATCCAGCCATTGCGGGTGCAGCGAGATG
AAGCCATCTATGAGTGTACAGCTACTAACAGCCTGGGTGAGATCAACACTAGTGCCAAGCTCTCAGTGCTCGAAGAGGAACAGCTGCCCC
CTGGGTTCCCTTCCATCGACATGGGGCCTCAGCTGAAGGTGGTGGAGAAGGCACGCACAGCCACCATGCTATGTGCCGCAGGCGGAAATC
CAGACCCTGAGATTTCTTGGTTCAAGGACTTCCTTCCTGTAGACCCTGCCACGAGCAACGGCCGCATCAAGCAGCTGCGTTCAGGTGCCT
TGCAGATAGAGAGCAGTGAGGAATCCGACCAAGGCAAGTACGAGTGTGTGGCGACCAACTCGGCAGGCACACGTTACTCAGCCCCTGCGA
ACCTGTATGTGCGAGTGCGCCGCGTGGCTCCTCGTTTCTCCATCCCTCCCAGCAGCCAGGAGGTGATGCCAGGCGGCAGCGTGAACCTGA
CATGCGTGGCAGTGGGTGCACCCATGCCCTACGTGAAGTGGATGATGGGGGCCGAGGAGCTCACCAAGGAGGATGAGATGCCAGTTGGCC
GCAACGTCCTGGAGCTCAGCAATGTCGTACGCTCTGCCAACTACACCTGTGTGGCCATCTCCTCGCTGGGCATGATCGAGGCCACAGCCC
AGGTCACAGTGAAAGGGCGAATCAAAGCCATCCAGCTGGAGTACTCAGAGGCCCGGAGAACGATGACCAACGCCCTTCGCAAGGCCCCTC
AGCACACAGCTGTCGGCTTCAAACAGACGGTGCACAAGCTTCTCATCGTGGTGGAGCTGTTGCTGGGGGAGATCCCTGACCGGCTGCAGT
TCCGCCAGCCCTCCCTCAAGCGCTCACTCATGCCCTATTTCCTTCTGACTCAAGCTGTCAGGACAGGAAACCTAGCCAAGTTCAACCAGG
TCCTGGATCAGTTTGGGGAGAAGTTTCAAGCAGATGGGACCTACACCCTAATTATCCGGCTGCGGCACAACGTGATTAAGACAGGTGTAC
GCATGATCAGCCTCTCCTATTCCCGAATCTCCTTGGCTGACATCGCCCAGAAGCTGCAGTTGGATAGCCCCGAAGATGCAGAGTTCATTG
TTGCCAAGGCCATCCGGGATGGTGTCATTGAGGCCAGCATCAACCACGAGAAGGGCTATGTCCAATCCAAGGAGATGATTGACATCTATT
CCACCCGAGAGCCCCAGCTAGCCTTCCACCAGCGCATCTCCTTCTGCCTAGATATCCACAACATGTCTGTCAAGGCCATGAGGTTTCCTC
CCAAATCGTACAACAAGGACTTGGAGTCTGCAGAGGAACGGCGTGAGCGAGAACAGCAGGACTTGGAGTTTGCCAAGGAGATGGCAGAAG
ATGATGATGACAGCTTCCCTTGAGCTGGGGGGCTGGGGAGGGGTAGGGGGAATGGGGACAGGCTCTTTCCCCCTTGGGGGTCCCCTGCCC
AGGGCACTGTCCCCATTTTCCCACACACAGCTCATATGCTGCATTCGTGCAGGGGGTGGGGGTGCTGGGAGCCAGCCACCCTGACCTCCC
CCAGGGCTCCTCCCCAGCCGGTGACTTACTGTACAGCAGGCAGGAGGGTGGGCAGGCAACCTCCCCGGGCAGGGTCCTGGCCAGCAGTGT
GGGAGCAGGAGGGGAAGGATAGTTCTGTGTACTCCTTTAGGGAGTGGGGGACTAGAACTGGGATGTCTTGGCTTGTATGTTTTTTGAAGC

>In-frame_ENST00000438120_ENST00000264639_TCGA-FP-A8CX_PTPRF_chr1_44054671_+_PSMD3_chr17_38146346_length(amino acids)=568AA_start in transcript=296_stop in transcript=2002
MWLAVELEPWMAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEV
IEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFK
DFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPM
PYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKGRIKAIQLEYSEARRTMTNALRKAPQHTAVGFKQ
TVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPYFLLTQAVRTGNLAKFNQVLDQFGEKFQADGTYTLIIRLRHNVIKTGVRMISLSYSR
ISLADIAQKLQLDSPEDAEFIVAKAIRDGVIEASINHEKGYVQSKEMIDIYSTREPQLAFHQRISFCLDIHNMSVKAMRFPPKSYNKDLE

--------------------------------------------------------------
>In-frame_ENST00000438120_ENST00000541736_TCGA-FP-A8CX_PTPRF_chr1_44054671_+_PSMD3_chr17_38146346_length(transcript)=2126nt_BP=1275nt
GCGGTGGCGGCGGCAGAGGCGGCGGCTCCAGCTTCGGCTCCGGCTCGGGCTCGGGCTCCGGCTCCGGCTCCGGCTCCGGCTCCAGCTCGG
GTGGCGGTGGCGGGAGCGGGACCAGGTGGAGGCGGCGGCGGCAGAGGAGTGGGAGCAGCGGCCCTAGCGGCTTGCGGGGGGACATGCGGA
CCGACGGCCCCTGGATAGGCGGAAGGAGTGGAGGCCCTGGTGCCCGGCCCTTGGTGCTGAGTATCCAGCAAGAGTGACCGGGGTGAAGAA
GCAAAGACTCGGTTGATTGTCCTGGGCTGTGGCTGGCTGTGGAGCTAGAGCCCTGGATGGCCCCTGAGCCAGCCCCAGGGAGGACGATGG
TGCCCCTTGTGCCTGCACTGGTGATGCTTGGTTTGGTGGCAGGCGCCCATGGTGACAGCAAACCTGTCTTCATTAAAGTCCCTGAGGACC
AGACTGGGCTGTCAGGAGGGGTAGCCTCCTTCGTGTGCCAAGCTACAGGAGAACCCAAGCCGCGCATCACATGGATGAAGAAGGGGAAGA
AAGTCAGCTCCCAGCGCTTCGAGGTCATTGAGTTTGATGATGGGGCAGGGTCAGTGCTTCGGATCCAGCCATTGCGGGTGCAGCGAGATG
AAGCCATCTATGAGTGTACAGCTACTAACAGCCTGGGTGAGATCAACACTAGTGCCAAGCTCTCAGTGCTCGAAGAGGAACAGCTGCCCC
CTGGGTTCCCTTCCATCGACATGGGGCCTCAGCTGAAGGTGGTGGAGAAGGCACGCACAGCCACCATGCTATGTGCCGCAGGCGGAAATC
CAGACCCTGAGATTTCTTGGTTCAAGGACTTCCTTCCTGTAGACCCTGCCACGAGCAACGGCCGCATCAAGCAGCTGCGTTCAGGTGCCT
TGCAGATAGAGAGCAGTGAGGAATCCGACCAAGGCAAGTACGAGTGTGTGGCGACCAACTCGGCAGGCACACGTTACTCAGCCCCTGCGA
ACCTGTATGTGCGAGTGCGCCGCGTGGCTCCTCGTTTCTCCATCCCTCCCAGCAGCCAGGAGGTGATGCCAGGCGGCAGCGTGAACCTGA
CATGCGTGGCAGTGGGTGCACCCATGCCCTACGTGAAGTGGATGATGGGGGCCGAGGAGCTCACCAAGGAGGATGAGATGCCAGTTGGCC
GCAACGTCCTGGAGCTCAGCAATGTCGTACGCTCTGCCAACTACACCTGTGTGGCCATCTCCTCGCTGGGCATGATCGAGGCCACAGCCC
AGGTCACAGTGAAAGGGCGAATCAAAGCCATCCAGCTGGAGTACTCAGAGGCCCGGAGAACGATGACCAACGCCCTTCGCAAGGCCCCTC
AGCACACAGCTGTCGGCTTCAAACAGACGGTGCACAAGCTTCTCATCGTGGTGGAGCTGTTGCTGGGGGAGATCCCTGACCGGCTGCAGT
TCCGCCAGCCCTCCCTCAAGCGCTCACTCATGCCCTATTTCCTTCTGACTCAAGCTGTCAGGACAGGAAACCTAGCCAAGTTCAACCAGG
TCCTGGATCAGTTTGGGGAGAAGTTTCAAGCAGATGGGACCTACACCCTAATTATCCGGCTGCGGCACAACGTGATTAAGACAGGTGTAC
GCATGATCAGCCTCTCCTATTCCCGAATCTCCTTGGCTGACATCGCCCAGAAGCTGCAGTTGGATAGCCCCGAAGATGCAGAGTTCATTG
TTGCCAAGGCCATCCGGGATGGTGTCATTGAGGCCAGCATCAACCACGAGAAGGGCTATGTCCAATCCAAGGAGATGATTGACATCTATT
CCACCCGAGAGCCCCAGCTAGCCTTCCACCAGCGCATCTCCTTCTGCCTAGATATCCACAACATGTCTGTCAAGGGTTGGTAAGATTAAA
AGAAGTCCCTGTATTGAGGCACTTAGCGAAGTCTAAATTGTAAAAAAGATGGCGCTGGTATCTAGCTCCACAAAAGGGCCATGAGGTTTC
CTCCCAAATCGTACAACAAGGACTTGGAGTCTGCAGAGGAACGGCGTGAGCGAGAACAGCAGGACTTGGAGTTTGCCAAGGAGATGGCAG

>In-frame_ENST00000438120_ENST00000541736_TCGA-FP-A8CX_PTPRF_chr1_44054671_+_PSMD3_chr17_38146346_length(amino acids)=528AA_start in transcript=296_stop in transcript=1882
MWLAVELEPWMAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEV
IEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFK
DFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPM
PYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKGRIKAIQLEYSEARRTMTNALRKAPQHTAVGFKQ
TVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPYFLLTQAVRTGNLAKFNQVLDQFGEKFQADGTYTLIIRLRHNVIKTGVRMISLSYSR

--------------------------------------------------------------
>In-frame_ENST00000372413_ENST00000264639_TCGA-FP-A8CX_PTPRF_chr1_44054671_+_PSMD3_chr17_38146346_length(transcript)=2102nt_BP=995nt
GGTTGATTGTCCTGGGCTGTGGCTGGCTGTGGAGCTAGAGCCCTGGATGGCCCCTGAGCCAGCCCCAGGGAGGACGATGGTGCCCCTTGT
GCCTGCACTGGTGATGCTTGGTTTGGTGGCAGGCGCCCATGGTGACAGCAAACCTGTCTTCATTAAAGTCCCTGAGGACCAGACTGGGCT
GTCAGGAGGGGTAGCCTCCTTCGTGTGCCAAGCTACAGGAGAACCCAAGCCGCGCATCACATGGATGAAGAAGGGGAAGAAAGTCAGCTC
CCAGCGCTTCGAGGTCATTGAGTTTGATGATGGGGCAGGGTCAGTGCTTCGGATCCAGCCATTGCGGGTGCAGCGAGATGAAGCCATCTA
TGAGTGTACAGCTACTAACAGCCTGGGTGAGATCAACACTAGTGCCAAGCTCTCAGTGCTCGAAGAGGAACAGCTGCCCCCTGGGTTCCC
TTCCATCGACATGGGGCCTCAGCTGAAGGTGGTGGAGAAGGCACGCACAGCCACCATGCTATGTGCCGCAGGCGGAAATCCAGACCCTGA
GATTTCTTGGTTCAAGGACTTCCTTCCTGTAGACCCTGCCACGAGCAACGGCCGCATCAAGCAGCTGCGTTCAGGTGCCTTGCAGATAGA
GAGCAGTGAGGAATCCGACCAAGGCAAGTACGAGTGTGTGGCGACCAACTCGGCAGGCACACGTTACTCAGCCCCTGCGAACCTGTATGT
GCGAGTGCGCCGCGTGGCTCCTCGTTTCTCCATCCCTCCCAGCAGCCAGGAGGTGATGCCAGGCGGCAGCGTGAACCTGACATGCGTGGC
AGTGGGTGCACCCATGCCCTACGTGAAGTGGATGATGGGGGCCGAGGAGCTCACCAAGGAGGATGAGATGCCAGTTGGCCGCAACGTCCT
GGAGCTCAGCAATGTCGTACGCTCTGCCAACTACACCTGTGTGGCCATCTCCTCGCTGGGCATGATCGAGGCCACAGCCCAGGTCACAGT
GAAAGGGCGAATCAAAGCCATCCAGCTGGAGTACTCAGAGGCCCGGAGAACGATGACCAACGCCCTTCGCAAGGCCCCTCAGCACACAGC
TGTCGGCTTCAAACAGACGGTGCACAAGCTTCTCATCGTGGTGGAGCTGTTGCTGGGGGAGATCCCTGACCGGCTGCAGTTCCGCCAGCC
CTCCCTCAAGCGCTCACTCATGCCCTATTTCCTTCTGACTCAAGCTGTCAGGACAGGAAACCTAGCCAAGTTCAACCAGGTCCTGGATCA
GTTTGGGGAGAAGTTTCAAGCAGATGGGACCTACACCCTAATTATCCGGCTGCGGCACAACGTGATTAAGACAGGTGTACGCATGATCAG
CCTCTCCTATTCCCGAATCTCCTTGGCTGACATCGCCCAGAAGCTGCAGTTGGATAGCCCCGAAGATGCAGAGTTCATTGTTGCCAAGGC
CATCCGGGATGGTGTCATTGAGGCCAGCATCAACCACGAGAAGGGCTATGTCCAATCCAAGGAGATGATTGACATCTATTCCACCCGAGA
GCCCCAGCTAGCCTTCCACCAGCGCATCTCCTTCTGCCTAGATATCCACAACATGTCTGTCAAGGCCATGAGGTTTCCTCCCAAATCGTA
CAACAAGGACTTGGAGTCTGCAGAGGAACGGCGTGAGCGAGAACAGCAGGACTTGGAGTTTGCCAAGGAGATGGCAGAAGATGATGATGA
CAGCTTCCCTTGAGCTGGGGGGCTGGGGAGGGGTAGGGGGAATGGGGACAGGCTCTTTCCCCCTTGGGGGTCCCCTGCCCAGGGCACTGT
CCCCATTTTCCCACACACAGCTCATATGCTGCATTCGTGCAGGGGGTGGGGGTGCTGGGAGCCAGCCACCCTGACCTCCCCCAGGGCTCC
TCCCCAGCCGGTGACTTACTGTACAGCAGGCAGGAGGGTGGGCAGGCAACCTCCCCGGGCAGGGTCCTGGCCAGCAGTGTGGGAGCAGGA
GGGGAAGGATAGTTCTGTGTACTCCTTTAGGGAGTGGGGGACTAGAACTGGGATGTCTTGGCTTGTATGTTTTTTGAAGCTTCGATTATG

>In-frame_ENST00000372413_ENST00000264639_TCGA-FP-A8CX_PTPRF_chr1_44054671_+_PSMD3_chr17_38146346_length(amino acids)=568AA_start in transcript=16_stop in transcript=1722
MWLAVELEPWMAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEV
IEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFK
DFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPM
PYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKGRIKAIQLEYSEARRTMTNALRKAPQHTAVGFKQ
TVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPYFLLTQAVRTGNLAKFNQVLDQFGEKFQADGTYTLIIRLRHNVIKTGVRMISLSYSR
ISLADIAQKLQLDSPEDAEFIVAKAIRDGVIEASINHEKGYVQSKEMIDIYSTREPQLAFHQRISFCLDIHNMSVKAMRFPPKSYNKDLE

--------------------------------------------------------------
>In-frame_ENST00000372413_ENST00000541736_TCGA-FP-A8CX_PTPRF_chr1_44054671_+_PSMD3_chr17_38146346_length(transcript)=1846nt_BP=995nt
GGTTGATTGTCCTGGGCTGTGGCTGGCTGTGGAGCTAGAGCCCTGGATGGCCCCTGAGCCAGCCCCAGGGAGGACGATGGTGCCCCTTGT
GCCTGCACTGGTGATGCTTGGTTTGGTGGCAGGCGCCCATGGTGACAGCAAACCTGTCTTCATTAAAGTCCCTGAGGACCAGACTGGGCT
GTCAGGAGGGGTAGCCTCCTTCGTGTGCCAAGCTACAGGAGAACCCAAGCCGCGCATCACATGGATGAAGAAGGGGAAGAAAGTCAGCTC
CCAGCGCTTCGAGGTCATTGAGTTTGATGATGGGGCAGGGTCAGTGCTTCGGATCCAGCCATTGCGGGTGCAGCGAGATGAAGCCATCTA
TGAGTGTACAGCTACTAACAGCCTGGGTGAGATCAACACTAGTGCCAAGCTCTCAGTGCTCGAAGAGGAACAGCTGCCCCCTGGGTTCCC
TTCCATCGACATGGGGCCTCAGCTGAAGGTGGTGGAGAAGGCACGCACAGCCACCATGCTATGTGCCGCAGGCGGAAATCCAGACCCTGA
GATTTCTTGGTTCAAGGACTTCCTTCCTGTAGACCCTGCCACGAGCAACGGCCGCATCAAGCAGCTGCGTTCAGGTGCCTTGCAGATAGA
GAGCAGTGAGGAATCCGACCAAGGCAAGTACGAGTGTGTGGCGACCAACTCGGCAGGCACACGTTACTCAGCCCCTGCGAACCTGTATGT
GCGAGTGCGCCGCGTGGCTCCTCGTTTCTCCATCCCTCCCAGCAGCCAGGAGGTGATGCCAGGCGGCAGCGTGAACCTGACATGCGTGGC
AGTGGGTGCACCCATGCCCTACGTGAAGTGGATGATGGGGGCCGAGGAGCTCACCAAGGAGGATGAGATGCCAGTTGGCCGCAACGTCCT
GGAGCTCAGCAATGTCGTACGCTCTGCCAACTACACCTGTGTGGCCATCTCCTCGCTGGGCATGATCGAGGCCACAGCCCAGGTCACAGT
GAAAGGGCGAATCAAAGCCATCCAGCTGGAGTACTCAGAGGCCCGGAGAACGATGACCAACGCCCTTCGCAAGGCCCCTCAGCACACAGC
TGTCGGCTTCAAACAGACGGTGCACAAGCTTCTCATCGTGGTGGAGCTGTTGCTGGGGGAGATCCCTGACCGGCTGCAGTTCCGCCAGCC
CTCCCTCAAGCGCTCACTCATGCCCTATTTCCTTCTGACTCAAGCTGTCAGGACAGGAAACCTAGCCAAGTTCAACCAGGTCCTGGATCA
GTTTGGGGAGAAGTTTCAAGCAGATGGGACCTACACCCTAATTATCCGGCTGCGGCACAACGTGATTAAGACAGGTGTACGCATGATCAG
CCTCTCCTATTCCCGAATCTCCTTGGCTGACATCGCCCAGAAGCTGCAGTTGGATAGCCCCGAAGATGCAGAGTTCATTGTTGCCAAGGC
CATCCGGGATGGTGTCATTGAGGCCAGCATCAACCACGAGAAGGGCTATGTCCAATCCAAGGAGATGATTGACATCTATTCCACCCGAGA
GCCCCAGCTAGCCTTCCACCAGCGCATCTCCTTCTGCCTAGATATCCACAACATGTCTGTCAAGGGTTGGTAAGATTAAAAGAAGTCCCT
GTATTGAGGCACTTAGCGAAGTCTAAATTGTAAAAAAGATGGCGCTGGTATCTAGCTCCACAAAAGGGCCATGAGGTTTCCTCCCAAATC
GTACAACAAGGACTTGGAGTCTGCAGAGGAACGGCGTGAGCGAGAACAGCAGGACTTGGAGTTTGCCAAGGAGATGGCAGAAGATGATGA

>In-frame_ENST00000372413_ENST00000541736_TCGA-FP-A8CX_PTPRF_chr1_44054671_+_PSMD3_chr17_38146346_length(amino acids)=528AA_start in transcript=16_stop in transcript=1602
MWLAVELEPWMAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEV
IEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFK
DFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPM
PYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKGRIKAIQLEYSEARRTMTNALRKAPQHTAVGFKQ
TVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPYFLLTQAVRTGNLAKFNQVLDQFGEKFQADGTYTLIIRLRHNVIKTGVRMISLSYSR

--------------------------------------------------------------
>In-frame_ENST00000372414_ENST00000264639_TCGA-FP-A8CX_PTPRF_chr1_44054671_+_PSMD3_chr17_38146346_length(transcript)=2102nt_BP=995nt
GGTTGATTGTCCTGGGCTGTGGCTGGCTGTGGAGCTAGAGCCCTGGATGGCCCCTGAGCCAGCCCCAGGGAGGACGATGGTGCCCCTTGT
GCCTGCACTGGTGATGCTTGGTTTGGTGGCAGGCGCCCATGGTGACAGCAAACCTGTCTTCATTAAAGTCCCTGAGGACCAGACTGGGCT
GTCAGGAGGGGTAGCCTCCTTCGTGTGCCAAGCTACAGGAGAACCCAAGCCGCGCATCACATGGATGAAGAAGGGGAAGAAAGTCAGCTC
CCAGCGCTTCGAGGTCATTGAGTTTGATGATGGGGCAGGGTCAGTGCTTCGGATCCAGCCATTGCGGGTGCAGCGAGATGAAGCCATCTA
TGAGTGTACAGCTACTAACAGCCTGGGTGAGATCAACACTAGTGCCAAGCTCTCAGTGCTCGAAGAGGAACAGCTGCCCCCTGGGTTCCC
TTCCATCGACATGGGGCCTCAGCTGAAGGTGGTGGAGAAGGCACGCACAGCCACCATGCTATGTGCCGCAGGCGGAAATCCAGACCCTGA
GATTTCTTGGTTCAAGGACTTCCTTCCTGTAGACCCTGCCACGAGCAACGGCCGCATCAAGCAGCTGCGTTCAGGTGCCTTGCAGATAGA
GAGCAGTGAGGAATCCGACCAAGGCAAGTACGAGTGTGTGGCGACCAACTCGGCAGGCACACGTTACTCAGCCCCTGCGAACCTGTATGT
GCGAGTGCGCCGCGTGGCTCCTCGTTTCTCCATCCCTCCCAGCAGCCAGGAGGTGATGCCAGGCGGCAGCGTGAACCTGACATGCGTGGC
AGTGGGTGCACCCATGCCCTACGTGAAGTGGATGATGGGGGCCGAGGAGCTCACCAAGGAGGATGAGATGCCAGTTGGCCGCAACGTCCT
GGAGCTCAGCAATGTCGTACGCTCTGCCAACTACACCTGTGTGGCCATCTCCTCGCTGGGCATGATCGAGGCCACAGCCCAGGTCACAGT
GAAAGGGCGAATCAAAGCCATCCAGCTGGAGTACTCAGAGGCCCGGAGAACGATGACCAACGCCCTTCGCAAGGCCCCTCAGCACACAGC
TGTCGGCTTCAAACAGACGGTGCACAAGCTTCTCATCGTGGTGGAGCTGTTGCTGGGGGAGATCCCTGACCGGCTGCAGTTCCGCCAGCC
CTCCCTCAAGCGCTCACTCATGCCCTATTTCCTTCTGACTCAAGCTGTCAGGACAGGAAACCTAGCCAAGTTCAACCAGGTCCTGGATCA
GTTTGGGGAGAAGTTTCAAGCAGATGGGACCTACACCCTAATTATCCGGCTGCGGCACAACGTGATTAAGACAGGTGTACGCATGATCAG
CCTCTCCTATTCCCGAATCTCCTTGGCTGACATCGCCCAGAAGCTGCAGTTGGATAGCCCCGAAGATGCAGAGTTCATTGTTGCCAAGGC
CATCCGGGATGGTGTCATTGAGGCCAGCATCAACCACGAGAAGGGCTATGTCCAATCCAAGGAGATGATTGACATCTATTCCACCCGAGA
GCCCCAGCTAGCCTTCCACCAGCGCATCTCCTTCTGCCTAGATATCCACAACATGTCTGTCAAGGCCATGAGGTTTCCTCCCAAATCGTA
CAACAAGGACTTGGAGTCTGCAGAGGAACGGCGTGAGCGAGAACAGCAGGACTTGGAGTTTGCCAAGGAGATGGCAGAAGATGATGATGA
CAGCTTCCCTTGAGCTGGGGGGCTGGGGAGGGGTAGGGGGAATGGGGACAGGCTCTTTCCCCCTTGGGGGTCCCCTGCCCAGGGCACTGT
CCCCATTTTCCCACACACAGCTCATATGCTGCATTCGTGCAGGGGGTGGGGGTGCTGGGAGCCAGCCACCCTGACCTCCCCCAGGGCTCC
TCCCCAGCCGGTGACTTACTGTACAGCAGGCAGGAGGGTGGGCAGGCAACCTCCCCGGGCAGGGTCCTGGCCAGCAGTGTGGGAGCAGGA
GGGGAAGGATAGTTCTGTGTACTCCTTTAGGGAGTGGGGGACTAGAACTGGGATGTCTTGGCTTGTATGTTTTTTGAAGCTTCGATTATG

>In-frame_ENST00000372414_ENST00000264639_TCGA-FP-A8CX_PTPRF_chr1_44054671_+_PSMD3_chr17_38146346_length(amino acids)=568AA_start in transcript=16_stop in transcript=1722
MWLAVELEPWMAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEV
IEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFK
DFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPM
PYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKGRIKAIQLEYSEARRTMTNALRKAPQHTAVGFKQ
TVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPYFLLTQAVRTGNLAKFNQVLDQFGEKFQADGTYTLIIRLRHNVIKTGVRMISLSYSR
ISLADIAQKLQLDSPEDAEFIVAKAIRDGVIEASINHEKGYVQSKEMIDIYSTREPQLAFHQRISFCLDIHNMSVKAMRFPPKSYNKDLE

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>In-frame_ENST00000372414_ENST00000541736_TCGA-FP-A8CX_PTPRF_chr1_44054671_+_PSMD3_chr17_38146346_length(transcript)=1846nt_BP=995nt
GGTTGATTGTCCTGGGCTGTGGCTGGCTGTGGAGCTAGAGCCCTGGATGGCCCCTGAGCCAGCCCCAGGGAGGACGATGGTGCCCCTTGT
GCCTGCACTGGTGATGCTTGGTTTGGTGGCAGGCGCCCATGGTGACAGCAAACCTGTCTTCATTAAAGTCCCTGAGGACCAGACTGGGCT
GTCAGGAGGGGTAGCCTCCTTCGTGTGCCAAGCTACAGGAGAACCCAAGCCGCGCATCACATGGATGAAGAAGGGGAAGAAAGTCAGCTC
CCAGCGCTTCGAGGTCATTGAGTTTGATGATGGGGCAGGGTCAGTGCTTCGGATCCAGCCATTGCGGGTGCAGCGAGATGAAGCCATCTA
TGAGTGTACAGCTACTAACAGCCTGGGTGAGATCAACACTAGTGCCAAGCTCTCAGTGCTCGAAGAGGAACAGCTGCCCCCTGGGTTCCC
TTCCATCGACATGGGGCCTCAGCTGAAGGTGGTGGAGAAGGCACGCACAGCCACCATGCTATGTGCCGCAGGCGGAAATCCAGACCCTGA
GATTTCTTGGTTCAAGGACTTCCTTCCTGTAGACCCTGCCACGAGCAACGGCCGCATCAAGCAGCTGCGTTCAGGTGCCTTGCAGATAGA
GAGCAGTGAGGAATCCGACCAAGGCAAGTACGAGTGTGTGGCGACCAACTCGGCAGGCACACGTTACTCAGCCCCTGCGAACCTGTATGT
GCGAGTGCGCCGCGTGGCTCCTCGTTTCTCCATCCCTCCCAGCAGCCAGGAGGTGATGCCAGGCGGCAGCGTGAACCTGACATGCGTGGC
AGTGGGTGCACCCATGCCCTACGTGAAGTGGATGATGGGGGCCGAGGAGCTCACCAAGGAGGATGAGATGCCAGTTGGCCGCAACGTCCT
GGAGCTCAGCAATGTCGTACGCTCTGCCAACTACACCTGTGTGGCCATCTCCTCGCTGGGCATGATCGAGGCCACAGCCCAGGTCACAGT
GAAAGGGCGAATCAAAGCCATCCAGCTGGAGTACTCAGAGGCCCGGAGAACGATGACCAACGCCCTTCGCAAGGCCCCTCAGCACACAGC
TGTCGGCTTCAAACAGACGGTGCACAAGCTTCTCATCGTGGTGGAGCTGTTGCTGGGGGAGATCCCTGACCGGCTGCAGTTCCGCCAGCC
CTCCCTCAAGCGCTCACTCATGCCCTATTTCCTTCTGACTCAAGCTGTCAGGACAGGAAACCTAGCCAAGTTCAACCAGGTCCTGGATCA
GTTTGGGGAGAAGTTTCAAGCAGATGGGACCTACACCCTAATTATCCGGCTGCGGCACAACGTGATTAAGACAGGTGTACGCATGATCAG
CCTCTCCTATTCCCGAATCTCCTTGGCTGACATCGCCCAGAAGCTGCAGTTGGATAGCCCCGAAGATGCAGAGTTCATTGTTGCCAAGGC
CATCCGGGATGGTGTCATTGAGGCCAGCATCAACCACGAGAAGGGCTATGTCCAATCCAAGGAGATGATTGACATCTATTCCACCCGAGA
GCCCCAGCTAGCCTTCCACCAGCGCATCTCCTTCTGCCTAGATATCCACAACATGTCTGTCAAGGGTTGGTAAGATTAAAAGAAGTCCCT
GTATTGAGGCACTTAGCGAAGTCTAAATTGTAAAAAAGATGGCGCTGGTATCTAGCTCCACAAAAGGGCCATGAGGTTTCCTCCCAAATC
GTACAACAAGGACTTGGAGTCTGCAGAGGAACGGCGTGAGCGAGAACAGCAGGACTTGGAGTTTGCCAAGGAGATGGCAGAAGATGATGA

>In-frame_ENST00000372414_ENST00000541736_TCGA-FP-A8CX_PTPRF_chr1_44054671_+_PSMD3_chr17_38146346_length(amino acids)=528AA_start in transcript=16_stop in transcript=1602
MWLAVELEPWMAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEV
IEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFK
DFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPM
PYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKGRIKAIQLEYSEARRTMTNALRKAPQHTAVGFKQ
TVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPYFLLTQAVRTGNLAKFNQVLDQFGEKFQADGTYTLIIRLRHNVIKTGVRMISLSYSR

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Fusion Gene PPI Analysis for PTPRF-PSMD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PTPRF-PSMD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTPRF-PSMD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTPRFC0024623Malignant neoplasm of stomach1CTD_human
HgenePTPRFC0038356Stomach Neoplasms1CTD_human
HgenePTPRFC0175755Congenital absent nipple1GENOMICS_ENGLAND
HgenePTPRFC0235874Disease Exacerbation1CTD_human
HgenePTPRFC0345967Malignant mesothelioma1CTD_human
HgenePTPRFC0432357Congenital absence of breast with absent nipple1ORPHANET
HgenePTPRFC1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgenePSMD3C0019693HIV Infections1CTD_human
TgenePSMD3C4505456HIV Coinfection1CTD_human