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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PTPRS-AGTRAP (FusionGDB2 ID:70089)

Fusion Gene Summary for PTPRS-AGTRAP

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRS-AGTRAP
Fusion gene ID: 70089
HgeneTgene
Gene symbol

PTPRS

AGTRAP

Gene ID

5802

57085

Gene nameprotein tyrosine phosphatase receptor type Sangiotensin II receptor associated protein
SynonymsPTPSIGMA|R-PTP-S|R-PTP-sigmaATRAP
Cytomap

19p13.3

1p36.22

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase Sprotein tyrosine phosphatase PTPsigmareceptor-type tyrosine-protein phosphatase sigmatype-1 angiotensin II receptor-associated proteinAT1 receptor-associated proteinATI receptor-associated proteinangiotensin II, type I receptor-associated protein
Modification date2020032220200327
UniProtAcc.

Q6RW13

Ensembl transtripts involved in fusion geneENST00000588552, ENST00000262963, 
ENST00000372412, ENST00000348075, 
ENST00000357368, ENST00000353284, 
ENST00000587303, ENST00000588012, 
ENST00000592099, ENST00000590509, 
ENST00000376637, ENST00000400895, 
ENST00000491346, ENST00000376629, 
ENST00000376627, ENST00000314340, 
ENST00000452018, ENST00000510878, 
Fusion gene scores* DoF score20 X 19 X 8=30407 X 5 X 5=175
# samples 237
** MAII scorelog2(23/3040*10)=-3.72436555738657
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPRS [Title/Abstract] AND AGTRAP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPTPRS(5219320)-AGTRAP(11807496), # samples:2
Anticipated loss of major functional domain due to fusion event.PTPRS-AGTRAP seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PTPRS-AGTRAP seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPRS

GO:0006470

protein dephosphorylation

8524829

HgenePTPRS

GO:0099560

synaptic membrane adhesion

23345436


check buttonFusion gene breakpoints across PTPRS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across AGTRAP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-VR-AA4GPTPRSchr19

5219320

-AGTRAPchr1

11807496

+
ChimerDB4ESCATCGA-VR-AA4GPTPRSchr19

5219320

-AGTRAPchr1

11807496

+


Top

Fusion Gene ORF analysis for PTPRS-AGTRAP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000588552ENST00000376637PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5UTR-3CDSENST00000588552ENST00000400895PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5UTR-3UTRENST00000588552ENST00000491346PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5UTR-3UTRENST00000588552ENST00000376629PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5UTR-3UTRENST00000588552ENST00000376627PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5UTR-3UTRENST00000588552ENST00000314340PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5UTR-3UTRENST00000588552ENST00000452018PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5UTR-intronENST00000588552ENST00000510878PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
Frame-shiftENST00000262963ENST00000376637PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
Frame-shiftENST00000262963ENST00000400895PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000262963ENST00000491346PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000262963ENST00000376629PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000262963ENST00000376627PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000262963ENST00000314340PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000262963ENST00000452018PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-intronENST00000262963ENST00000510878PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
In-frameENST00000372412ENST00000376637PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
In-frameENST00000372412ENST00000400895PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000372412ENST00000491346PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000372412ENST00000376629PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000372412ENST00000376627PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000372412ENST00000314340PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000372412ENST00000452018PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-intronENST00000372412ENST00000510878PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
Frame-shiftENST00000348075ENST00000376637PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
Frame-shiftENST00000348075ENST00000400895PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000348075ENST00000491346PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000348075ENST00000376629PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000348075ENST00000376627PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000348075ENST00000314340PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000348075ENST00000452018PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-intronENST00000348075ENST00000510878PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
Frame-shiftENST00000357368ENST00000376637PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
Frame-shiftENST00000357368ENST00000400895PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000357368ENST00000491346PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000357368ENST00000376629PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000357368ENST00000376627PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000357368ENST00000314340PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000357368ENST00000452018PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-intronENST00000357368ENST00000510878PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
Frame-shiftENST00000353284ENST00000376637PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
Frame-shiftENST00000353284ENST00000400895PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000353284ENST00000491346PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000353284ENST00000376629PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000353284ENST00000376627PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000353284ENST00000314340PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000353284ENST00000452018PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-intronENST00000353284ENST00000510878PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
Frame-shiftENST00000587303ENST00000376637PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
Frame-shiftENST00000587303ENST00000400895PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000587303ENST00000491346PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000587303ENST00000376629PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000587303ENST00000376627PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000587303ENST00000314340PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000587303ENST00000452018PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-intronENST00000587303ENST00000510878PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
Frame-shiftENST00000588012ENST00000376637PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
Frame-shiftENST00000588012ENST00000400895PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000588012ENST00000491346PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000588012ENST00000376629PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000588012ENST00000376627PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000588012ENST00000314340PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000588012ENST00000452018PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-intronENST00000588012ENST00000510878PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
Frame-shiftENST00000592099ENST00000376637PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
Frame-shiftENST00000592099ENST00000400895PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000592099ENST00000491346PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000592099ENST00000376629PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000592099ENST00000376627PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000592099ENST00000314340PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-3UTRENST00000592099ENST00000452018PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
5CDS-intronENST00000592099ENST00000510878PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
intron-3CDSENST00000590509ENST00000376637PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
intron-3CDSENST00000590509ENST00000400895PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
intron-3UTRENST00000590509ENST00000491346PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
intron-3UTRENST00000590509ENST00000376629PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
intron-3UTRENST00000590509ENST00000376627PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
intron-3UTRENST00000590509ENST00000314340PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
intron-3UTRENST00000590509ENST00000452018PTPRSchr19

5219320

-AGTRAPchr1

11807496

+
intron-intronENST00000590509ENST00000510878PTPRSchr19

5219320

-AGTRAPchr1

11807496

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000372412PTPRSchr195219320-ENST00000376637AGTRAPchr111807496+5076416122544691414
ENST00000372412PTPRSchr195219320-ENST00000400895AGTRAPchr111807496+4703416122544451406

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000372412ENST00000376637PTPRSchr195219320-AGTRAPchr111807496+0.0030215740.9969784
ENST00000372412ENST00000400895PTPRSchr195219320-AGTRAPchr111807496+0.0035395930.9964604

Top

Fusion Genomic Features for PTPRS-AGTRAP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PTPRSchr195219319-AGTRAPchr111807496+3.26E-060.9999968
PTPRSchr195219319-AGTRAPchr111807496+3.26E-060.9999968

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PTPRS-AGTRAP


check button Go to

FGviewer for the breakpoints of chr19:5219320-chr1:11807496

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AGTRAP

Q6RW13

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. {ECO:0000269|PubMed:12960423}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPRSchr19:5219320chr1:11807496ENST00000348075-1933641_6441285.66666666666671911.0Compositional biasNote=Poly-Pro
HgenePTPRSchr19:5219320chr1:11807496ENST00000353284-1529641_644876.66666666666661502.0Compositional biasNote=Poly-Pro
HgenePTPRSchr19:5219320chr1:11807496ENST00000357368-2338641_6441307.66666666666671949.0Compositional biasNote=Poly-Pro
HgenePTPRSchr19:5219320chr1:11807496ENST00000587303-2237641_6441307.66666666666671949.0Compositional biasNote=Poly-Pro
HgenePTPRSchr19:5219320chr1:11807496ENST00000588012-1832641_6441285.66666666666671911.0Compositional biasNote=Poly-Pro
HgenePTPRSchr19:5219320chr1:11807496ENST00000592099-1428641_644876.66666666666661502.0Compositional biasNote=Poly-Pro
HgenePTPRSchr19:5219320chr1:11807496ENST00000348075-19331036_11201285.66666666666671911.0DomainFibronectin type-III 8
HgenePTPRSchr19:5219320chr1:11807496ENST00000348075-1933135_2331285.66666666666671911.0DomainNote=Ig-like C2-type 2
HgenePTPRSchr19:5219320chr1:11807496ENST00000348075-1933245_3271285.66666666666671911.0DomainNote=Ig-like C2-type 3
HgenePTPRSchr19:5219320chr1:11807496ENST00000348075-1933334_4241285.66666666666671911.0DomainFibronectin type-III 1
HgenePTPRSchr19:5219320chr1:11807496ENST00000348075-193333_1231285.66666666666671911.0DomainNote=Ig-like C2-type 1
HgenePTPRSchr19:5219320chr1:11807496ENST00000348075-1933429_5231285.66666666666671911.0DomainFibronectin type-III 2
HgenePTPRSchr19:5219320chr1:11807496ENST00000348075-1933527_6161285.66666666666671911.0DomainFibronectin type-III 3
HgenePTPRSchr19:5219320chr1:11807496ENST00000348075-1933621_7181285.66666666666671911.0DomainFibronectin type-III 4
HgenePTPRSchr19:5219320chr1:11807496ENST00000348075-1933723_8311285.66666666666671911.0DomainFibronectin type-III 5
HgenePTPRSchr19:5219320chr1:11807496ENST00000348075-1933832_9301285.66666666666671911.0DomainFibronectin type-III 6
HgenePTPRSchr19:5219320chr1:11807496ENST00000348075-1933931_10331285.66666666666671911.0DomainFibronectin type-III 7
HgenePTPRSchr19:5219320chr1:11807496ENST00000353284-1529135_233876.66666666666661502.0DomainNote=Ig-like C2-type 2
HgenePTPRSchr19:5219320chr1:11807496ENST00000353284-1529245_327876.66666666666661502.0DomainNote=Ig-like C2-type 3
HgenePTPRSchr19:5219320chr1:11807496ENST00000353284-1529334_424876.66666666666661502.0DomainFibronectin type-III 1
HgenePTPRSchr19:5219320chr1:11807496ENST00000353284-152933_123876.66666666666661502.0DomainNote=Ig-like C2-type 1
HgenePTPRSchr19:5219320chr1:11807496ENST00000353284-1529429_523876.66666666666661502.0DomainFibronectin type-III 2
HgenePTPRSchr19:5219320chr1:11807496ENST00000353284-1529527_616876.66666666666661502.0DomainFibronectin type-III 3
HgenePTPRSchr19:5219320chr1:11807496ENST00000353284-1529621_718876.66666666666661502.0DomainFibronectin type-III 4
HgenePTPRSchr19:5219320chr1:11807496ENST00000353284-1529723_831876.66666666666661502.0DomainFibronectin type-III 5
HgenePTPRSchr19:5219320chr1:11807496ENST00000357368-23381036_11201307.66666666666671949.0DomainFibronectin type-III 8
HgenePTPRSchr19:5219320chr1:11807496ENST00000357368-2338135_2331307.66666666666671949.0DomainNote=Ig-like C2-type 2
HgenePTPRSchr19:5219320chr1:11807496ENST00000357368-2338245_3271307.66666666666671949.0DomainNote=Ig-like C2-type 3
HgenePTPRSchr19:5219320chr1:11807496ENST00000357368-2338334_4241307.66666666666671949.0DomainFibronectin type-III 1
HgenePTPRSchr19:5219320chr1:11807496ENST00000357368-233833_1231307.66666666666671949.0DomainNote=Ig-like C2-type 1
HgenePTPRSchr19:5219320chr1:11807496ENST00000357368-2338429_5231307.66666666666671949.0DomainFibronectin type-III 2
HgenePTPRSchr19:5219320chr1:11807496ENST00000357368-2338527_6161307.66666666666671949.0DomainFibronectin type-III 3
HgenePTPRSchr19:5219320chr1:11807496ENST00000357368-2338621_7181307.66666666666671949.0DomainFibronectin type-III 4
HgenePTPRSchr19:5219320chr1:11807496ENST00000357368-2338723_8311307.66666666666671949.0DomainFibronectin type-III 5
HgenePTPRSchr19:5219320chr1:11807496ENST00000357368-2338832_9301307.66666666666671949.0DomainFibronectin type-III 6
HgenePTPRSchr19:5219320chr1:11807496ENST00000357368-2338931_10331307.66666666666671949.0DomainFibronectin type-III 7
HgenePTPRSchr19:5219320chr1:11807496ENST00000587303-22371036_11201307.66666666666671949.0DomainFibronectin type-III 8
HgenePTPRSchr19:5219320chr1:11807496ENST00000587303-2237135_2331307.66666666666671949.0DomainNote=Ig-like C2-type 2
HgenePTPRSchr19:5219320chr1:11807496ENST00000587303-2237245_3271307.66666666666671949.0DomainNote=Ig-like C2-type 3
HgenePTPRSchr19:5219320chr1:11807496ENST00000587303-2237334_4241307.66666666666671949.0DomainFibronectin type-III 1
HgenePTPRSchr19:5219320chr1:11807496ENST00000587303-223733_1231307.66666666666671949.0DomainNote=Ig-like C2-type 1
HgenePTPRSchr19:5219320chr1:11807496ENST00000587303-2237429_5231307.66666666666671949.0DomainFibronectin type-III 2
HgenePTPRSchr19:5219320chr1:11807496ENST00000587303-2237527_6161307.66666666666671949.0DomainFibronectin type-III 3
HgenePTPRSchr19:5219320chr1:11807496ENST00000587303-2237621_7181307.66666666666671949.0DomainFibronectin type-III 4
HgenePTPRSchr19:5219320chr1:11807496ENST00000587303-2237723_8311307.66666666666671949.0DomainFibronectin type-III 5
HgenePTPRSchr19:5219320chr1:11807496ENST00000587303-2237832_9301307.66666666666671949.0DomainFibronectin type-III 6
HgenePTPRSchr19:5219320chr1:11807496ENST00000587303-2237931_10331307.66666666666671949.0DomainFibronectin type-III 7
HgenePTPRSchr19:5219320chr1:11807496ENST00000588012-18321036_11201285.66666666666671911.0DomainFibronectin type-III 8
HgenePTPRSchr19:5219320chr1:11807496ENST00000588012-1832135_2331285.66666666666671911.0DomainNote=Ig-like C2-type 2
HgenePTPRSchr19:5219320chr1:11807496ENST00000588012-1832245_3271285.66666666666671911.0DomainNote=Ig-like C2-type 3
HgenePTPRSchr19:5219320chr1:11807496ENST00000588012-1832334_4241285.66666666666671911.0DomainFibronectin type-III 1
HgenePTPRSchr19:5219320chr1:11807496ENST00000588012-183233_1231285.66666666666671911.0DomainNote=Ig-like C2-type 1
HgenePTPRSchr19:5219320chr1:11807496ENST00000588012-1832429_5231285.66666666666671911.0DomainFibronectin type-III 2
HgenePTPRSchr19:5219320chr1:11807496ENST00000588012-1832527_6161285.66666666666671911.0DomainFibronectin type-III 3
HgenePTPRSchr19:5219320chr1:11807496ENST00000588012-1832621_7181285.66666666666671911.0DomainFibronectin type-III 4
HgenePTPRSchr19:5219320chr1:11807496ENST00000588012-1832723_8311285.66666666666671911.0DomainFibronectin type-III 5
HgenePTPRSchr19:5219320chr1:11807496ENST00000588012-1832832_9301285.66666666666671911.0DomainFibronectin type-III 6
HgenePTPRSchr19:5219320chr1:11807496ENST00000588012-1832931_10331285.66666666666671911.0DomainFibronectin type-III 7
HgenePTPRSchr19:5219320chr1:11807496ENST00000592099-1428135_233876.66666666666661502.0DomainNote=Ig-like C2-type 2
HgenePTPRSchr19:5219320chr1:11807496ENST00000592099-1428245_327876.66666666666661502.0DomainNote=Ig-like C2-type 3
HgenePTPRSchr19:5219320chr1:11807496ENST00000592099-1428334_424876.66666666666661502.0DomainFibronectin type-III 1
HgenePTPRSchr19:5219320chr1:11807496ENST00000592099-142833_123876.66666666666661502.0DomainNote=Ig-like C2-type 1
HgenePTPRSchr19:5219320chr1:11807496ENST00000592099-1428429_523876.66666666666661502.0DomainFibronectin type-III 2
HgenePTPRSchr19:5219320chr1:11807496ENST00000592099-1428527_616876.66666666666661502.0DomainFibronectin type-III 3
HgenePTPRSchr19:5219320chr1:11807496ENST00000592099-1428621_718876.66666666666661502.0DomainFibronectin type-III 4
HgenePTPRSchr19:5219320chr1:11807496ENST00000592099-1428723_831876.66666666666661502.0DomainFibronectin type-III 5
HgenePTPRSchr19:5219320chr1:11807496ENST00000348075-193368_721285.66666666666671911.0RegionImportant for binding to glycosaminoglycan chains
HgenePTPRSchr19:5219320chr1:11807496ENST00000353284-152968_72876.66666666666661502.0RegionImportant for binding to glycosaminoglycan chains
HgenePTPRSchr19:5219320chr1:11807496ENST00000357368-233868_721307.66666666666671949.0RegionImportant for binding to glycosaminoglycan chains
HgenePTPRSchr19:5219320chr1:11807496ENST00000587303-223768_721307.66666666666671949.0RegionImportant for binding to glycosaminoglycan chains
HgenePTPRSchr19:5219320chr1:11807496ENST00000588012-183268_721285.66666666666671911.0RegionImportant for binding to glycosaminoglycan chains
HgenePTPRSchr19:5219320chr1:11807496ENST00000592099-142868_72876.66666666666661502.0RegionImportant for binding to glycosaminoglycan chains
HgenePTPRSchr19:5219320chr1:11807496ENST00000348075-193330_12821285.66666666666671911.0Topological domainExtracellular
HgenePTPRSchr19:5219320chr1:11807496ENST00000357368-233830_12821307.66666666666671949.0Topological domainExtracellular
HgenePTPRSchr19:5219320chr1:11807496ENST00000587303-223730_12821307.66666666666671949.0Topological domainExtracellular
HgenePTPRSchr19:5219320chr1:11807496ENST00000588012-183230_12821285.66666666666671911.0Topological domainExtracellular
HgenePTPRSchr19:5219320chr1:11807496ENST00000357368-23381283_13031307.66666666666671949.0TransmembraneHelical
HgenePTPRSchr19:5219320chr1:11807496ENST00000587303-22371283_13031307.66666666666671949.0TransmembraneHelical
TgeneAGTRAPchr19:5219320chr1:11807496ENST0000031434015108_15920.666666666666668160.0Topological domainCytoplasmic
TgeneAGTRAPchr19:5219320chr1:11807496ENST000003143401545_5520.666666666666668160.0Topological domainCytoplasmic
TgeneAGTRAPchr19:5219320chr1:11807496ENST000003143401577_8620.666666666666668160.0Topological domainExtracellular
TgeneAGTRAPchr19:5219320chr1:11807496ENST0000037662915108_15920.666666666666668153.0Topological domainCytoplasmic
TgeneAGTRAPchr19:5219320chr1:11807496ENST000003766291545_5520.666666666666668153.0Topological domainCytoplasmic
TgeneAGTRAPchr19:5219320chr1:11807496ENST000003766291577_8620.666666666666668153.0Topological domainExtracellular
TgeneAGTRAPchr19:5219320chr1:11807496ENST0000037663704108_1599.0112.0Topological domainCytoplasmic
TgeneAGTRAPchr19:5219320chr1:11807496ENST000003766370445_559.0112.0Topological domainCytoplasmic
TgeneAGTRAPchr19:5219320chr1:11807496ENST000003766370477_869.0112.0Topological domainExtracellular
TgeneAGTRAPchr19:5219320chr1:11807496ENST0000040089526108_15953.0190.66666666666666Topological domainCytoplasmic
TgeneAGTRAPchr19:5219320chr1:11807496ENST000004008952677_8653.0190.66666666666666Topological domainExtracellular
TgeneAGTRAPchr19:5219320chr1:11807496ENST0000045201826108_15953.0156.0Topological domainCytoplasmic
TgeneAGTRAPchr19:5219320chr1:11807496ENST000004520182677_8653.0156.0Topological domainExtracellular
TgeneAGTRAPchr19:5219320chr1:11807496ENST000003143401524_4420.666666666666668160.0TransmembraneHelical
TgeneAGTRAPchr19:5219320chr1:11807496ENST000003143401556_7620.666666666666668160.0TransmembraneHelical
TgeneAGTRAPchr19:5219320chr1:11807496ENST000003143401587_10720.666666666666668160.0TransmembraneHelical
TgeneAGTRAPchr19:5219320chr1:11807496ENST000003766291524_4420.666666666666668153.0TransmembraneHelical
TgeneAGTRAPchr19:5219320chr1:11807496ENST000003766291556_7620.666666666666668153.0TransmembraneHelical
TgeneAGTRAPchr19:5219320chr1:11807496ENST000003766291587_10720.666666666666668153.0TransmembraneHelical
TgeneAGTRAPchr19:5219320chr1:11807496ENST000003766370424_449.0112.0TransmembraneHelical
TgeneAGTRAPchr19:5219320chr1:11807496ENST000003766370456_769.0112.0TransmembraneHelical
TgeneAGTRAPchr19:5219320chr1:11807496ENST000003766370487_1079.0112.0TransmembraneHelical
TgeneAGTRAPchr19:5219320chr1:11807496ENST000004008952656_7653.0190.66666666666666TransmembraneHelical
TgeneAGTRAPchr19:5219320chr1:11807496ENST000004008952687_10753.0190.66666666666666TransmembraneHelical
TgeneAGTRAPchr19:5219320chr1:11807496ENST000004520182656_7653.0156.0TransmembraneHelical
TgeneAGTRAPchr19:5219320chr1:11807496ENST000004520182687_10753.0156.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPRSchr19:5219320chr1:11807496ENST00000348075-19331393_16481285.66666666666671911.0DomainTyrosine-protein phosphatase 1
HgenePTPRSchr19:5219320chr1:11807496ENST00000348075-19331680_19391285.66666666666671911.0DomainTyrosine-protein phosphatase 2
HgenePTPRSchr19:5219320chr1:11807496ENST00000353284-15291036_1120876.66666666666661502.0DomainFibronectin type-III 8
HgenePTPRSchr19:5219320chr1:11807496ENST00000353284-15291393_1648876.66666666666661502.0DomainTyrosine-protein phosphatase 1
HgenePTPRSchr19:5219320chr1:11807496ENST00000353284-15291680_1939876.66666666666661502.0DomainTyrosine-protein phosphatase 2
HgenePTPRSchr19:5219320chr1:11807496ENST00000353284-1529832_930876.66666666666661502.0DomainFibronectin type-III 6
HgenePTPRSchr19:5219320chr1:11807496ENST00000353284-1529931_1033876.66666666666661502.0DomainFibronectin type-III 7
HgenePTPRSchr19:5219320chr1:11807496ENST00000357368-23381393_16481307.66666666666671949.0DomainTyrosine-protein phosphatase 1
HgenePTPRSchr19:5219320chr1:11807496ENST00000357368-23381680_19391307.66666666666671949.0DomainTyrosine-protein phosphatase 2
HgenePTPRSchr19:5219320chr1:11807496ENST00000587303-22371393_16481307.66666666666671949.0DomainTyrosine-protein phosphatase 1
HgenePTPRSchr19:5219320chr1:11807496ENST00000587303-22371680_19391307.66666666666671949.0DomainTyrosine-protein phosphatase 2
HgenePTPRSchr19:5219320chr1:11807496ENST00000588012-18321393_16481285.66666666666671911.0DomainTyrosine-protein phosphatase 1
HgenePTPRSchr19:5219320chr1:11807496ENST00000588012-18321680_19391285.66666666666671911.0DomainTyrosine-protein phosphatase 2
HgenePTPRSchr19:5219320chr1:11807496ENST00000592099-14281036_1120876.66666666666661502.0DomainFibronectin type-III 8
HgenePTPRSchr19:5219320chr1:11807496ENST00000592099-14281393_1648876.66666666666661502.0DomainTyrosine-protein phosphatase 1
HgenePTPRSchr19:5219320chr1:11807496ENST00000592099-14281680_1939876.66666666666661502.0DomainTyrosine-protein phosphatase 2
HgenePTPRSchr19:5219320chr1:11807496ENST00000592099-1428832_930876.66666666666661502.0DomainFibronectin type-III 6
HgenePTPRSchr19:5219320chr1:11807496ENST00000592099-1428931_1033876.66666666666661502.0DomainFibronectin type-III 7
HgenePTPRSchr19:5219320chr1:11807496ENST00000348075-19331589_15951285.66666666666671911.0RegionSubstrate binding
HgenePTPRSchr19:5219320chr1:11807496ENST00000353284-15291589_1595876.66666666666661502.0RegionSubstrate binding
HgenePTPRSchr19:5219320chr1:11807496ENST00000357368-23381589_15951307.66666666666671949.0RegionSubstrate binding
HgenePTPRSchr19:5219320chr1:11807496ENST00000587303-22371589_15951307.66666666666671949.0RegionSubstrate binding
HgenePTPRSchr19:5219320chr1:11807496ENST00000588012-18321589_15951285.66666666666671911.0RegionSubstrate binding
HgenePTPRSchr19:5219320chr1:11807496ENST00000592099-14281589_1595876.66666666666661502.0RegionSubstrate binding
HgenePTPRSchr19:5219320chr1:11807496ENST00000348075-19331304_19481285.66666666666671911.0Topological domainCytoplasmic
HgenePTPRSchr19:5219320chr1:11807496ENST00000353284-15291304_1948876.66666666666661502.0Topological domainCytoplasmic
HgenePTPRSchr19:5219320chr1:11807496ENST00000353284-152930_1282876.66666666666661502.0Topological domainExtracellular
HgenePTPRSchr19:5219320chr1:11807496ENST00000357368-23381304_19481307.66666666666671949.0Topological domainCytoplasmic
HgenePTPRSchr19:5219320chr1:11807496ENST00000587303-22371304_19481307.66666666666671949.0Topological domainCytoplasmic
HgenePTPRSchr19:5219320chr1:11807496ENST00000588012-18321304_19481285.66666666666671911.0Topological domainCytoplasmic
HgenePTPRSchr19:5219320chr1:11807496ENST00000592099-14281304_1948876.66666666666661502.0Topological domainCytoplasmic
HgenePTPRSchr19:5219320chr1:11807496ENST00000592099-142830_1282876.66666666666661502.0Topological domainExtracellular
HgenePTPRSchr19:5219320chr1:11807496ENST00000348075-19331283_13031285.66666666666671911.0TransmembraneHelical
HgenePTPRSchr19:5219320chr1:11807496ENST00000353284-15291283_1303876.66666666666661502.0TransmembraneHelical
HgenePTPRSchr19:5219320chr1:11807496ENST00000588012-18321283_13031285.66666666666671911.0TransmembraneHelical
HgenePTPRSchr19:5219320chr1:11807496ENST00000592099-14281283_1303876.66666666666661502.0TransmembraneHelical
TgeneAGTRAPchr19:5219320chr1:11807496ENST00000314340151_2320.666666666666668160.0Topological domainExtracellular
TgeneAGTRAPchr19:5219320chr1:11807496ENST00000376629151_2320.666666666666668153.0Topological domainExtracellular
TgeneAGTRAPchr19:5219320chr1:11807496ENST00000376637041_239.0112.0Topological domainExtracellular
TgeneAGTRAPchr19:5219320chr1:11807496ENST00000400895261_2353.0190.66666666666666Topological domainExtracellular
TgeneAGTRAPchr19:5219320chr1:11807496ENST000004008952645_5553.0190.66666666666666Topological domainCytoplasmic
TgeneAGTRAPchr19:5219320chr1:11807496ENST00000452018261_2353.0156.0Topological domainExtracellular
TgeneAGTRAPchr19:5219320chr1:11807496ENST000004520182645_5553.0156.0Topological domainCytoplasmic
TgeneAGTRAPchr19:5219320chr1:11807496ENST000004008952624_4453.0190.66666666666666TransmembraneHelical
TgeneAGTRAPchr19:5219320chr1:11807496ENST000004520182624_4453.0156.0TransmembraneHelical


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Fusion Gene Sequence for PTPRS-AGTRAP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000372412_ENST00000376637_TCGA-VR-AA4G_PTPRS_chr19_5219320_-_AGTRAP_chr1_11807496_length(transcript)=5076nt_BP=4161nt
CCTCGCGCCGCCCGCCCGGCAGCCCGGCCGGCGCGCGCACGCCGCGAGCCGCTGGCGCTCGGGCTCCGCTCGGATCCCATGCAACAGCCA
CGATGTGAAGCGGGGCAGAGCCGGGGGAGCCCAGCCCAGCCAGCCTCCAGACGTTGCCCCATCTGACGCTCGGCTCGAGGCCTCTCTGTG
AGGGACCGGGGGGCCATCCCCCTCCAGGGCGGAGATCGGAGGTCGCTGCCAAGCATGGCGCCCACCTGGGGCCCTGGCATGGTGTCTGTG
GTTGGTCCCATGGGCCTCCTTGTGGTCCTGCTCGTTGGAGGCTGTGCAGCAGAAGAGCCCCCCAGGTTTATCAAAGAACCCAAGGACCAG
ATCGGCGTGTCGGGGGGTGTGGCCTCTTTCGTGTGTCAGGCCACGGGTGACCCCAAGCCACGAGTGACCTGGAACAAGAAGGGCAAGAAG
GTCAACTCTCAGCGCTTTGAGACGATTGAGTTTGATGAGAGTGCAGGGGCAGTGCTGAGGATCCAGCCGCTGAGGACACCGCGGGATGAA
AACGTGTACGAGTGTGTGGCCCAGAACTCGGTTGGGGAGATCACAGTCCATGCCAAGCTTACTGTCCTCCGAGAGGACCAGCTGCCCTCT
GGCTTCCCCAACATCGACATGGGCCCACAGTTGAAGGTGGTGGAGCGGACACGGACAGCCACCATGCTCTGTGCAGCCAGCGGCAACCCT
GACCCTGAGATCACCTGGTTCAAGGACTTCCTGCCTGTGGATCCTAGTGCCAGCAATGGACGCATCAAACAGCTGCGACGTTCAGAAACC
TTTGAAAGCACTCCGATTCGAGGAGCCCTGCAGATTGAAAGCAGTGAGGAAACCGACCAGGGCAAATATGAGTGTGTGGCCACCAACAGC
GCCGGCGTGCGCTACTCCTCACCTGCCAACCTCTACGTGCGAGAGCTTCGAGAAGTCCGCCGCGTGGCCCCGCGCTTCTCCATCCTGCCC
ATGAGCCACGAGATCATGCCAGGGGGCAACGTGAACATCACCTGCGTGGCCGTGGGCTCGCCCATGCCATACGTGAAGTGGATGCAGGGG
GCCGAGGACCTGACCCCCGAGGATGACATGCCCGTGGGTCGGAACGTGCTGGAACTCACAGATGTCAAGGACTCGGCCAACTACACCTGC
GTGGCCATGTCCAGCCTGGGCGTCATTGAGGCGGTTGCTCAGATCACGGTGAAATCTCTCCCCAAAGCTCCCGGGACTCCCATGGTGACT
GAGAACACAGCCACCAGCATCACCATCACGTGGGACTCGGGCAACCCAGATCCTGTGTCCTATTACGTCATCGAATATAAATCCAAGAGC
CAAGACGGGCCGTATCAGATTAAAGAGGACATCACCACCACACGTTACAGCATCGGCGGCCTGAGCCCCAACTCGGAGTACGAGATCTGG
GTGTCGGCCGTCAACTCCATCGGCCAGGGGCCCCCCAGCGAGTCCGTGGTCACCCGCACAGGCGAGCAGGCCCCGGCCAGCGCGCCGCGG
AACGTGCAAGCCCGGATGCTCAGCGCGACCACCATGATTGTGCAGTGGGAGGAGCCGGTGGAGCCCAACGGCCTGATCCGCGGCTACCGC
GTCTACTACACCATGGAACCGGAGCACCCCGTGGGCAACTGGCAGAAGCACAACGTGGACGACAGCCTGCTGACCACCGTGGGCAGCCTG
CTGGAGGACGAGACCTACACCGTGCGGGTGCTCGCCTTCACCTCCGTCGGCGACGGGCCCCTCTCGGACCCCATCCAGGTCAAGACGCAG
CAGGGAGTGCCGGGCCAGCCCATGAACCTGCGGGCCGAGGCCAGGTCGGAGACCAGCATCACGCTGTCCTGGAGCCCCCCGCGGCAGGAG
AGTATCATCAAGTACGAGCTCCTCTTCCGGGAAGGCGACCATGGCCGGGAGGTGGGAAGGACCTTCGACCCGACGACTTCCTACGTGGTG
GAGGACCTGAAGCCCAACACGGAGTACGCCTTCCGCCTGGCGGCCCGCTCGCCGCAGGGCCTGGGCGCCTTCACCCCCGTGGTGCGGCAG
CGCACGCTGCAGTCCAAACCGTCAGCCCCCCCTCAAGACGTTAAATGTGTCAGCGTGCGCTCCACGGCCATTTTGGTAAGTTGGCGCCCG
CCGCCGCCGGAAACGCACAACGGGGCCCTGGTGGGCTACAGCGTCCGCTACCGACCGCTGGGCTCAGAGGACCCGGAACCCAAGGAGGTG
AACGGCATCCCCCCGACCACCACTCAGATCCTGCTGGAGGCCTTGGAGAAGTGGACCCAGTACCGCATCACGACTGTCGCTCACACAGAG
GTGGGACCAGGGCCCGAGAGCTCGCCCGTGGTCGTCCGCACCGACGAGGATGTGCCCAGCGCGCCGCCGCGGAAGGTGGAGGCGGAGGCG
CTCAACGCCACGGCCATCCGCGTGCTGTGGCGCTCGCCCGCGCCCGGCCGGCAGCACGGCCAGATCCGCGGCTACCAGGTCCACTACGTG
CGCATGGAGGGCGCCGAGGCCCGCGGGCCGCCGCGCATCAAGGACGTCATGCTGGCCGATGCCCAGTGGGAGACGGATGACACGGCCGAA
TATGAGATGGTCATCACAAACTTGCAGCCTGAGACCGCGTACTCCATCACGGTAGCCGCCTACACCATGAAGGGCGATGGCGCTCGCAGC
AAACCCAAGGTGGTTGTGACCAAGGGAGCAGTGCTGGGCCGCCCAACCCTGTCGGTGCAGCAGACCCCCGAGGGCAGCCTGCTGGCACGC
TGGGAGCCCCCGGCTGGCACCGCGGAGGACCAGGTGCTGGGCTACCGCCTGCAGTTTGGCCGTGAGGACTCGACGCCCCTGGCCACCCTG
GAGTTCCCGCCCTCCGAGGACCGCTACACGGCATCAGGCGTGCACAAGGGGGCCACGTATGTGTTCCGGCTTGCGGCCCGGAGCCGCGGC
GGCCTGGGCGAGGAGGCAGCCGAGGTCCTGAGCATCCCGGAGGACACGCCCCGTGGCCACCCGCAGATTCTGGAGGCGGCCGGCAACGCC
TCGGCCGGGACCGTCCTTCTCCGCTGGCTGCCACCCGTGCCCGCCGAGCGCAACGGGGCCATCGTCAAATACACGGTGGCCGTGCGGGAG
GCCGGTGCCCTGGGCCCTGCCCGAGAGACTGAGCTGCCGGCAGCGGCTGAGCCGGGCGCGGAGAACGCGCTCACGCTGCAGGGCCTGAAG
CCCGACACGGCCTATGACCTCCAAGTGCGAGCCCACACGCGCCGGGGCCCTGGCCCCTTCAGCCCCCCCGTCCGCTACCGGACGTTCCTG
CGGGACCAAGTCTCGCCCAAGAACTTCAAGGTGAAAATGATCATGAAGACATCAGTTCTGCTCAGCTGGGAGTTCCCTGACAACTACAAC
TCACCCACACCCTACAAGATCCAGTACAATGGGCTCACACTGGATGTGGATGGCCGTACCACCAAGAAGCTCATCACGCACCTCAAGCCC
CACACCTTCTACAACTTTGTGCTGACCAATCGCGGCAGCAGCCTGGGCGGCCTCCAGCAGACGGTCACCGCCTGGACTGCCTTCAACCTG
CTCAACGGCAAGCCCAGCGTCGCCCCCAAGCCTGATGCTGACGGCTTCATCATGGTGTATCTTCCTGACGGCCAGAGCCCCGTGCCTGTC
CAGAGCTATTTCATTGTGATGGTGCCACTGCGCAAGTCTCGTGGAGGCCAATTCCTGACCCCGCTGGGTAGCCCAGAGGACATGGATCTG
GAAGAGCTCATCCAGGACATCTCACGGCTACAGAGGCGCAGCCTGCGGCACTCGCGTCAGCTGGAGGTGCCCCGGCCCTATATTGCAGCT
CGCTTCTCTGTGCTGCCACCCACGTTCCATCCCGGCGACCAGAAGCAGTATGGCGGCTTCGATAACCGGGGCCTGGAGCCCGGCCACCGC
TATGTCCTCTTCGTGCTTGCCGTGCTTCAGAAGAGCGAGCCTACCTTTGCAGCCAGTCCCTTCTCAGACCCCTTCCAGCTGGATAACCCG
GACCCCCAGCCCATCGTGGATGGCGAGGAGGGGCTTATCTGGGTGATCGGGCCTGTGCTGGCCGTGGTCTTCATAATCTGCATTGTCATT
GCTATCCTGCTCTACAAGAAGGGGCTGCATTGTATTCTCAGGCTCCTATGCCTGGGCCAACTTCACCATCCTGGCCTTGGGCGTGTGGGC
TGTGGCTCAGCGGGACTCCATCGACGCCATAAGCATGTTTCTGGGTGGCTTGCTGGCCACCATCTTCCTGGACATCGTGCACATCAGCAT
CTTCTACCCGCGGGTCAGCCTCACGGACACGGGCCGCTTTGGCGTGGGCATGGCCATCCTCAGCTTGCTGCTCAAGCCGCTCTCCTGCTG
CTTCGTCTACCACATGTACCGGGAGCGCGGGGGTTTCCTTGGGTCTTCTCAGGACCGTAGTGCCTACCAGACGATTGACTCAGCAGAGGC
GCCCGCAGATCCCTTTGCAGTCCCAGAGGGCAGGAGTCAAGATGCCCGAGGGTACTGAAGCCAGCCACGCTGCGCCCGGCCCTGCCCCGG
GCCTTCCTCGTGCCTGGGAGGTCGTTCTAGGGATGCTCCTGACCTCCGTCTCTTGGACCTAAGATGGAATGTGTCCCCAGCTCAGGGATT
GCCTGAACCAAGAGGCCAGGAGCCCCCATGGGCCGCCCAGTACCATGCACACTCCTGTCCCGAACTCCCTGAGGCCTCCCCTCCCTTCAG
GGCACCCACTGGTTCCCAGGCTGGAACCAGGGTCTCTCTTTACCTCCTACCCCATGGTGGCACCACAGAGGCCCTCAGCCGAGTCCTGCC
TGAGTGTTGCAAGCTCAGGCCTTTAAGGACTGCTGATGCCCCCTCAGGCCTCCCCCAAGTTTGCTGGGCTTTGGTGGAAGCCCTGAGAGC
TTCAGGTCCTGCTCAGCCCGAGGAGCAGTCTGGCATGGGAGTGAGGCCCCGTCCTTCTCACTGCCTGGTCACATGGTGCCTAGGGATGCA

>In-frame_ENST00000372412_ENST00000376637_TCGA-VR-AA4G_PTPRS_chr19_5219320_-_AGTRAP_chr1_11807496_length(amino acids)=1414AA_start in transcript=225_stop in transcript=4469
MPSMAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESA
GAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDP
SASNGRIKQLRRSETFESTPIRGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITC
VAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN
PDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQ
WEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEAR
SETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVK
CVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTD
EDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYS
ITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVH
KGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPAA
AEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLD
VDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRG
GQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT
FAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKKGLHCILRLLCLGQLHHPGLGRVGCGSAGLHRRHKHVSG

--------------------------------------------------------------
>In-frame_ENST00000372412_ENST00000400895_TCGA-VR-AA4G_PTPRS_chr19_5219320_-_AGTRAP_chr1_11807496_length(transcript)=4703nt_BP=4161nt
CCTCGCGCCGCCCGCCCGGCAGCCCGGCCGGCGCGCGCACGCCGCGAGCCGCTGGCGCTCGGGCTCCGCTCGGATCCCATGCAACAGCCA
CGATGTGAAGCGGGGCAGAGCCGGGGGAGCCCAGCCCAGCCAGCCTCCAGACGTTGCCCCATCTGACGCTCGGCTCGAGGCCTCTCTGTG
AGGGACCGGGGGGCCATCCCCCTCCAGGGCGGAGATCGGAGGTCGCTGCCAAGCATGGCGCCCACCTGGGGCCCTGGCATGGTGTCTGTG
GTTGGTCCCATGGGCCTCCTTGTGGTCCTGCTCGTTGGAGGCTGTGCAGCAGAAGAGCCCCCCAGGTTTATCAAAGAACCCAAGGACCAG
ATCGGCGTGTCGGGGGGTGTGGCCTCTTTCGTGTGTCAGGCCACGGGTGACCCCAAGCCACGAGTGACCTGGAACAAGAAGGGCAAGAAG
GTCAACTCTCAGCGCTTTGAGACGATTGAGTTTGATGAGAGTGCAGGGGCAGTGCTGAGGATCCAGCCGCTGAGGACACCGCGGGATGAA
AACGTGTACGAGTGTGTGGCCCAGAACTCGGTTGGGGAGATCACAGTCCATGCCAAGCTTACTGTCCTCCGAGAGGACCAGCTGCCCTCT
GGCTTCCCCAACATCGACATGGGCCCACAGTTGAAGGTGGTGGAGCGGACACGGACAGCCACCATGCTCTGTGCAGCCAGCGGCAACCCT
GACCCTGAGATCACCTGGTTCAAGGACTTCCTGCCTGTGGATCCTAGTGCCAGCAATGGACGCATCAAACAGCTGCGACGTTCAGAAACC
TTTGAAAGCACTCCGATTCGAGGAGCCCTGCAGATTGAAAGCAGTGAGGAAACCGACCAGGGCAAATATGAGTGTGTGGCCACCAACAGC
GCCGGCGTGCGCTACTCCTCACCTGCCAACCTCTACGTGCGAGAGCTTCGAGAAGTCCGCCGCGTGGCCCCGCGCTTCTCCATCCTGCCC
ATGAGCCACGAGATCATGCCAGGGGGCAACGTGAACATCACCTGCGTGGCCGTGGGCTCGCCCATGCCATACGTGAAGTGGATGCAGGGG
GCCGAGGACCTGACCCCCGAGGATGACATGCCCGTGGGTCGGAACGTGCTGGAACTCACAGATGTCAAGGACTCGGCCAACTACACCTGC
GTGGCCATGTCCAGCCTGGGCGTCATTGAGGCGGTTGCTCAGATCACGGTGAAATCTCTCCCCAAAGCTCCCGGGACTCCCATGGTGACT
GAGAACACAGCCACCAGCATCACCATCACGTGGGACTCGGGCAACCCAGATCCTGTGTCCTATTACGTCATCGAATATAAATCCAAGAGC
CAAGACGGGCCGTATCAGATTAAAGAGGACATCACCACCACACGTTACAGCATCGGCGGCCTGAGCCCCAACTCGGAGTACGAGATCTGG
GTGTCGGCCGTCAACTCCATCGGCCAGGGGCCCCCCAGCGAGTCCGTGGTCACCCGCACAGGCGAGCAGGCCCCGGCCAGCGCGCCGCGG
AACGTGCAAGCCCGGATGCTCAGCGCGACCACCATGATTGTGCAGTGGGAGGAGCCGGTGGAGCCCAACGGCCTGATCCGCGGCTACCGC
GTCTACTACACCATGGAACCGGAGCACCCCGTGGGCAACTGGCAGAAGCACAACGTGGACGACAGCCTGCTGACCACCGTGGGCAGCCTG
CTGGAGGACGAGACCTACACCGTGCGGGTGCTCGCCTTCACCTCCGTCGGCGACGGGCCCCTCTCGGACCCCATCCAGGTCAAGACGCAG
CAGGGAGTGCCGGGCCAGCCCATGAACCTGCGGGCCGAGGCCAGGTCGGAGACCAGCATCACGCTGTCCTGGAGCCCCCCGCGGCAGGAG
AGTATCATCAAGTACGAGCTCCTCTTCCGGGAAGGCGACCATGGCCGGGAGGTGGGAAGGACCTTCGACCCGACGACTTCCTACGTGGTG
GAGGACCTGAAGCCCAACACGGAGTACGCCTTCCGCCTGGCGGCCCGCTCGCCGCAGGGCCTGGGCGCCTTCACCCCCGTGGTGCGGCAG
CGCACGCTGCAGTCCAAACCGTCAGCCCCCCCTCAAGACGTTAAATGTGTCAGCGTGCGCTCCACGGCCATTTTGGTAAGTTGGCGCCCG
CCGCCGCCGGAAACGCACAACGGGGCCCTGGTGGGCTACAGCGTCCGCTACCGACCGCTGGGCTCAGAGGACCCGGAACCCAAGGAGGTG
AACGGCATCCCCCCGACCACCACTCAGATCCTGCTGGAGGCCTTGGAGAAGTGGACCCAGTACCGCATCACGACTGTCGCTCACACAGAG
GTGGGACCAGGGCCCGAGAGCTCGCCCGTGGTCGTCCGCACCGACGAGGATGTGCCCAGCGCGCCGCCGCGGAAGGTGGAGGCGGAGGCG
CTCAACGCCACGGCCATCCGCGTGCTGTGGCGCTCGCCCGCGCCCGGCCGGCAGCACGGCCAGATCCGCGGCTACCAGGTCCACTACGTG
CGCATGGAGGGCGCCGAGGCCCGCGGGCCGCCGCGCATCAAGGACGTCATGCTGGCCGATGCCCAGTGGGAGACGGATGACACGGCCGAA
TATGAGATGGTCATCACAAACTTGCAGCCTGAGACCGCGTACTCCATCACGGTAGCCGCCTACACCATGAAGGGCGATGGCGCTCGCAGC
AAACCCAAGGTGGTTGTGACCAAGGGAGCAGTGCTGGGCCGCCCAACCCTGTCGGTGCAGCAGACCCCCGAGGGCAGCCTGCTGGCACGC
TGGGAGCCCCCGGCTGGCACCGCGGAGGACCAGGTGCTGGGCTACCGCCTGCAGTTTGGCCGTGAGGACTCGACGCCCCTGGCCACCCTG
GAGTTCCCGCCCTCCGAGGACCGCTACACGGCATCAGGCGTGCACAAGGGGGCCACGTATGTGTTCCGGCTTGCGGCCCGGAGCCGCGGC
GGCCTGGGCGAGGAGGCAGCCGAGGTCCTGAGCATCCCGGAGGACACGCCCCGTGGCCACCCGCAGATTCTGGAGGCGGCCGGCAACGCC
TCGGCCGGGACCGTCCTTCTCCGCTGGCTGCCACCCGTGCCCGCCGAGCGCAACGGGGCCATCGTCAAATACACGGTGGCCGTGCGGGAG
GCCGGTGCCCTGGGCCCTGCCCGAGAGACTGAGCTGCCGGCAGCGGCTGAGCCGGGCGCGGAGAACGCGCTCACGCTGCAGGGCCTGAAG
CCCGACACGGCCTATGACCTCCAAGTGCGAGCCCACACGCGCCGGGGCCCTGGCCCCTTCAGCCCCCCCGTCCGCTACCGGACGTTCCTG
CGGGACCAAGTCTCGCCCAAGAACTTCAAGGTGAAAATGATCATGAAGACATCAGTTCTGCTCAGCTGGGAGTTCCCTGACAACTACAAC
TCACCCACACCCTACAAGATCCAGTACAATGGGCTCACACTGGATGTGGATGGCCGTACCACCAAGAAGCTCATCACGCACCTCAAGCCC
CACACCTTCTACAACTTTGTGCTGACCAATCGCGGCAGCAGCCTGGGCGGCCTCCAGCAGACGGTCACCGCCTGGACTGCCTTCAACCTG
CTCAACGGCAAGCCCAGCGTCGCCCCCAAGCCTGATGCTGACGGCTTCATCATGGTGTATCTTCCTGACGGCCAGAGCCCCGTGCCTGTC
CAGAGCTATTTCATTGTGATGGTGCCACTGCGCAAGTCTCGTGGAGGCCAATTCCTGACCCCGCTGGGTAGCCCAGAGGACATGGATCTG
GAAGAGCTCATCCAGGACATCTCACGGCTACAGAGGCGCAGCCTGCGGCACTCGCGTCAGCTGGAGGTGCCCCGGCCCTATATTGCAGCT
CGCTTCTCTGTGCTGCCACCCACGTTCCATCCCGGCGACCAGAAGCAGTATGGCGGCTTCGATAACCGGGGCCTGGAGCCCGGCCACCGC
TATGTCCTCTTCGTGCTTGCCGTGCTTCAGAAGAGCGAGCCTACCTTTGCAGCCAGTCCCTTCTCAGACCCCTTCCAGCTGGATAACCCG
GACCCCCAGCCCATCGTGGATGGCGAGGAGGGGCTTATCTGGGTGATCGGGCCTGTGCTGGCCGTGGTCTTCATAATCTGCATTGTCATT
GCTATCCTGCTCTACAAGAAGGGGCTGCATTGTATTCTCAGGCTCCTATGCCTGGGCCAACTTCACCATCCTGGCCTTGGGCGTGTGGGC
TGTGGCTCAGCGGGACTCCATCGACGCCATAAGCATGTTTCTGGGTGGCTTGCTGGCCACCATCTTCCTGGACATCGTGCACATCAGCAT
CTTCTACCCGCGGGTCAGCCTCACGGACACGGGCCGCTTTGGCGTGGGCATGGCCATCCTCAGCTTGCTGCTCAAGCCGCTCTCCTGCTG
CTTCGTCTACCACATGTACCGGGAGCGCGGGGGTGAGCTCCTGGTCCACACTGGTTTCCTTGGGTCTTCTCAGGACCGTAGTGCCTACCA
GACGATTGACTCAGCAGAGGCGCCCGCAGATCCCTTTGCAGTCCCAGAGGGCAGGAGTCAAGATGCCCGAGGGTACTGAAGCCAGCCACG
CTGCGCCCGGCCCTGCCCCGGGCCTTCCTCGTGCCTGGGAGGTCGTTCTAGGGATGCTCCTGACCTCCGTCTCTTGGACCTAAGATGGAA

>In-frame_ENST00000372412_ENST00000400895_TCGA-VR-AA4G_PTPRS_chr19_5219320_-_AGTRAP_chr1_11807496_length(amino acids)=1406AA_start in transcript=225_stop in transcript=4445
MPSMAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESA
GAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDP
SASNGRIKQLRRSETFESTPIRGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITC
VAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN
PDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQ
WEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEAR
SETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVK
CVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTD
EDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYS
ITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVH
KGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPAA
AEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLD
VDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRG
GQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT
FAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKKGLHCILRLLCLGQLHHPGLGRVGCGSAGLHRRHKHVSG

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Fusion Gene PPI Analysis for PTPRS-AGTRAP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneAGTRAPchr19:5219320chr1:11807496ENST0000031434015110_12220.666666666666668160.0AGTR1
TgeneAGTRAPchr19:5219320chr1:11807496ENST0000037662915110_12220.666666666666668153.0AGTR1
TgeneAGTRAPchr19:5219320chr1:11807496ENST0000037663704110_1229.0112.0AGTR1
TgeneAGTRAPchr19:5219320chr1:11807496ENST0000040089526110_12253.0190.66666666666666AGTR1
TgeneAGTRAPchr19:5219320chr1:11807496ENST0000045201826110_12253.0156.0AGTR1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PTPRS-AGTRAP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTPRS-AGTRAP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource