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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PTPRU-SBSPON (FusionGDB2 ID:70136)

Fusion Gene Summary for PTPRU-SBSPON

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRU-SBSPON
Fusion gene ID: 70136
HgeneTgene
Gene symbol

PTPRU

SBSPON

Gene ID

10076

157869

Gene nameprotein tyrosine phosphatase receptor type Usomatomedin B and thrombospondin type 1 domain containing
SynonymsFMI|PCP-2|PTP|PTP-J|PTP-PI|PTP-RO|PTPPSI|PTPRO|PTPU2|R-PTP-PSI|R-PTP-U|hPTP-JC8orf84|RPESP
Cytomap

1p35.3

8q21.11

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase UPTP piReceptor protein tyrosine phosphatase hPTP-Jpancreatic carcinoma phosphatase 2pi R-PTP-Psiprotein-tyrosine phosphatase Jprotein-tyrosine phosphatase piprotein-tyrosine phosphatase receptor omicronrsomatomedin-B and thrombospondin type-1 domain-containing proteinRPE-spondin
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000345512, ENST00000373779, 
ENST00000356870, ENST00000323874, 
ENST00000428026, ENST00000460170, 
ENST00000415600, 		ENST00000297354, 
ENST00000519697, 
Fusion gene scores* DoF score8 X 6 X 7=3362 X 2 X 2=8
# samples 102
** MAII scorelog2(10/336*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: PTPRU [Title/Abstract] AND SBSPON [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPTPRU(29563229)-SBSPON(73984105), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPRU

GO:0006470

protein dephosphorylation

12501215

HgenePTPRU

GO:0008285

negative regulation of cell proliferation

16574648

HgenePTPRU

GO:0030336

negative regulation of cell migration

12501215|16574648

HgenePTPRU

GO:0034394

protein localization to cell surface

16574648

HgenePTPRU

GO:0090090

negative regulation of canonical Wnt signaling pathway

16574648

HgenePTPRU

GO:2000049

positive regulation of cell-cell adhesion mediated by cadherin

16574648


check buttonFusion gene breakpoints across PTPRU (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SBSPON (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-78-7153-01APTPRUchr1

29563229

+SBSPONchr8

73984105

-


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Fusion Gene ORF analysis for PTPRU-SBSPON

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000345512ENST00000297354PTPRUchr1

29563229

+SBSPONchr8

73984105

-
5CDS-5UTRENST00000345512ENST00000519697PTPRUchr1

29563229

+SBSPONchr8

73984105

-
In-frameENST00000373779ENST00000297354PTPRUchr1

29563229

+SBSPONchr8

73984105

-
5CDS-5UTRENST00000373779ENST00000519697PTPRUchr1

29563229

+SBSPONchr8

73984105

-
In-frameENST00000356870ENST00000297354PTPRUchr1

29563229

+SBSPONchr8

73984105

-
5CDS-5UTRENST00000356870ENST00000519697PTPRUchr1

29563229

+SBSPONchr8

73984105

-
In-frameENST00000323874ENST00000297354PTPRUchr1

29563229

+SBSPONchr8

73984105

-
5CDS-5UTRENST00000323874ENST00000519697PTPRUchr1

29563229

+SBSPONchr8

73984105

-
In-frameENST00000428026ENST00000297354PTPRUchr1

29563229

+SBSPONchr8

73984105

-
5CDS-5UTRENST00000428026ENST00000519697PTPRUchr1

29563229

+SBSPONchr8

73984105

-
In-frameENST00000460170ENST00000297354PTPRUchr1

29563229

+SBSPONchr8

73984105

-
5CDS-5UTRENST00000460170ENST00000519697PTPRUchr1

29563229

+SBSPONchr8

73984105

-
intron-3CDSENST00000415600ENST00000297354PTPRUchr1

29563229

+SBSPONchr8

73984105

-
intron-5UTRENST00000415600ENST00000519697PTPRUchr1

29563229

+SBSPONchr8

73984105

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000345512PTPRUchr129563229+ENST00000297354SBSPONchr873984105-3389202129587152
ENST00000373779PTPRUchr129563229+ENST00000297354SBSPONchr873984105-3389202129587152
ENST00000356870PTPRUchr129563229+ENST00000297354SBSPONchr873984105-3370183110568152
ENST00000323874PTPRUchr129563229+ENST00000297354SBSPONchr873984105-3370183110568152
ENST00000428026PTPRUchr129563229+ENST00000297354SBSPONchr873984105-335616996554152
ENST00000460170PTPRUchr129563229+ENST00000297354SBSPONchr873984105-3266796464152

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000345512ENST00000297354PTPRUchr129563229+SBSPONchr873984105-0.086530040.9134699
ENST00000373779ENST00000297354PTPRUchr129563229+SBSPONchr873984105-0.086530040.9134699
ENST00000356870ENST00000297354PTPRUchr129563229+SBSPONchr873984105-0.0868478340.9131522
ENST00000323874ENST00000297354PTPRUchr129563229+SBSPONchr873984105-0.0868478340.9131522
ENST00000428026ENST00000297354PTPRUchr129563229+SBSPONchr873984105-0.087099880.9129001
ENST00000460170ENST00000297354PTPRUchr129563229+SBSPONchr873984105-0.087287550.91271245

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Fusion Genomic Features for PTPRU-SBSPON


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PTPRU-SBSPON


check button Go to

FGviewer for the breakpoints of chr1:29563229-chr8:73984105

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPRUchr1:29563229chr8:73984105ENST00000345512+1311176_143924.3333333333333321447.0DomainTyrosine-protein phosphatase 2
HgenePTPRUchr1:29563229chr8:73984105ENST00000345512+131190_27524.3333333333333321447.0DomainNote=Ig-like C2-type
HgenePTPRUchr1:29563229chr8:73984105ENST00000345512+13125_18824.3333333333333321447.0DomainMAM
HgenePTPRUchr1:29563229chr8:73984105ENST00000345512+131288_38324.3333333333333321447.0DomainFibronectin type-III 1
HgenePTPRUchr1:29563229chr8:73984105ENST00000345512+131386_48424.3333333333333321447.0DomainFibronectin type-III 2
HgenePTPRUchr1:29563229chr8:73984105ENST00000345512+131485_59124.3333333333333321447.0DomainFibronectin type-III 3
HgenePTPRUchr1:29563229chr8:73984105ENST00000345512+131592_67424.3333333333333321447.0DomainFibronectin type-III 4
HgenePTPRUchr1:29563229chr8:73984105ENST00000345512+131888_114424.3333333333333321447.0DomainTyrosine-protein phosphatase 1
HgenePTPRUchr1:29563229chr8:73984105ENST00000373779+1301176_143924.3333333333333321437.0DomainTyrosine-protein phosphatase 2
HgenePTPRUchr1:29563229chr8:73984105ENST00000373779+130190_27524.3333333333333321437.0DomainNote=Ig-like C2-type
HgenePTPRUchr1:29563229chr8:73984105ENST00000373779+13025_18824.3333333333333321437.0DomainMAM
HgenePTPRUchr1:29563229chr8:73984105ENST00000373779+130288_38324.3333333333333321437.0DomainFibronectin type-III 1
HgenePTPRUchr1:29563229chr8:73984105ENST00000373779+130386_48424.3333333333333321437.0DomainFibronectin type-III 2
HgenePTPRUchr1:29563229chr8:73984105ENST00000373779+130485_59124.3333333333333321437.0DomainFibronectin type-III 3
HgenePTPRUchr1:29563229chr8:73984105ENST00000373779+130592_67424.3333333333333321437.0DomainFibronectin type-III 4
HgenePTPRUchr1:29563229chr8:73984105ENST00000373779+130888_114424.3333333333333321437.0DomainTyrosine-protein phosphatase 1
HgenePTPRUchr1:29563229chr8:73984105ENST00000428026+1301176_143924.3333333333333321434.0DomainTyrosine-protein phosphatase 2
HgenePTPRUchr1:29563229chr8:73984105ENST00000428026+130190_27524.3333333333333321434.0DomainNote=Ig-like C2-type
HgenePTPRUchr1:29563229chr8:73984105ENST00000428026+13025_18824.3333333333333321434.0DomainMAM
HgenePTPRUchr1:29563229chr8:73984105ENST00000428026+130288_38324.3333333333333321434.0DomainFibronectin type-III 1
HgenePTPRUchr1:29563229chr8:73984105ENST00000428026+130386_48424.3333333333333321434.0DomainFibronectin type-III 2
HgenePTPRUchr1:29563229chr8:73984105ENST00000428026+130485_59124.3333333333333321434.0DomainFibronectin type-III 3
HgenePTPRUchr1:29563229chr8:73984105ENST00000428026+130592_67424.3333333333333321434.0DomainFibronectin type-III 4
HgenePTPRUchr1:29563229chr8:73984105ENST00000428026+130888_114424.3333333333333321434.0DomainTyrosine-protein phosphatase 1
HgenePTPRUchr1:29563229chr8:73984105ENST00000460170+1311176_143924.3333333333333321441.0DomainTyrosine-protein phosphatase 2
HgenePTPRUchr1:29563229chr8:73984105ENST00000460170+131190_27524.3333333333333321441.0DomainNote=Ig-like C2-type
HgenePTPRUchr1:29563229chr8:73984105ENST00000460170+13125_18824.3333333333333321441.0DomainMAM
HgenePTPRUchr1:29563229chr8:73984105ENST00000460170+131288_38324.3333333333333321441.0DomainFibronectin type-III 1
HgenePTPRUchr1:29563229chr8:73984105ENST00000460170+131386_48424.3333333333333321441.0DomainFibronectin type-III 2
HgenePTPRUchr1:29563229chr8:73984105ENST00000460170+131485_59124.3333333333333321441.0DomainFibronectin type-III 3
HgenePTPRUchr1:29563229chr8:73984105ENST00000460170+131592_67424.3333333333333321441.0DomainFibronectin type-III 4
HgenePTPRUchr1:29563229chr8:73984105ENST00000460170+131888_114424.3333333333333321441.0DomainTyrosine-protein phosphatase 1
HgenePTPRUchr1:29563229chr8:73984105ENST00000345512+1311085_109124.3333333333333321447.0RegionSubstrate binding
HgenePTPRUchr1:29563229chr8:73984105ENST00000373779+1301085_109124.3333333333333321437.0RegionSubstrate binding
HgenePTPRUchr1:29563229chr8:73984105ENST00000428026+1301085_109124.3333333333333321434.0RegionSubstrate binding
HgenePTPRUchr1:29563229chr8:73984105ENST00000460170+1311085_109124.3333333333333321441.0RegionSubstrate binding
HgenePTPRUchr1:29563229chr8:73984105ENST00000345512+13119_74924.3333333333333321447.0Topological domainExtracellular
HgenePTPRUchr1:29563229chr8:73984105ENST00000345512+131771_144624.3333333333333321447.0Topological domainCytoplasmic
HgenePTPRUchr1:29563229chr8:73984105ENST00000373779+13019_74924.3333333333333321437.0Topological domainExtracellular
HgenePTPRUchr1:29563229chr8:73984105ENST00000373779+130771_144624.3333333333333321437.0Topological domainCytoplasmic
HgenePTPRUchr1:29563229chr8:73984105ENST00000428026+13019_74924.3333333333333321434.0Topological domainExtracellular
HgenePTPRUchr1:29563229chr8:73984105ENST00000428026+130771_144624.3333333333333321434.0Topological domainCytoplasmic
HgenePTPRUchr1:29563229chr8:73984105ENST00000460170+13119_74924.3333333333333321441.0Topological domainExtracellular
HgenePTPRUchr1:29563229chr8:73984105ENST00000460170+131771_144624.3333333333333321441.0Topological domainCytoplasmic
HgenePTPRUchr1:29563229chr8:73984105ENST00000345512+131750_77024.3333333333333321447.0TransmembraneHelical
HgenePTPRUchr1:29563229chr8:73984105ENST00000373779+130750_77024.3333333333333321437.0TransmembraneHelical
HgenePTPRUchr1:29563229chr8:73984105ENST00000428026+130750_77024.3333333333333321434.0TransmembraneHelical
HgenePTPRUchr1:29563229chr8:73984105ENST00000460170+131750_77024.3333333333333321441.0TransmembraneHelical
TgeneSBSPONchr1:29563229chr8:73984105ENST000002973541524_75136.33333333333334265.0DomainSMB
TgeneSBSPONchr1:29563229chr8:73984105ENST000002973541574_127136.33333333333334265.0DomainTSP type-1


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Fusion Gene Sequence for PTPRU-SBSPON


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000345512_ENST00000297354_TCGA-78-7153-01A_PTPRU_chr1_29563229_+_SBSPON_chr8_73984105_length(transcript)=3389nt_BP=202nt
GGCGCCAGTCCCGCTCCGCGCCGCGCCGCTCCGCTCCGGCTCGGGCTCCGGCTCGCCTCGGGCTGGGCTCGGGCTCCGGGGGCGGCGTCC
CCCGCGCCGGGCCCCGGGACGGGCGGCGACGCTCCAACCATGGCCCGTGCCCAGGCGCTCGTGCTGGCACTCACCTTCCAGCTCTGCGCG
CCGGAGACCGAGACTCCGGCAGTTCCTGCCTTTATAACTACCTCTGCATTCAACAAGGAGAGAACACGACAAGCTACGTCTCCACACTGG
TCTACACACACAGAGGATGCTGGATACTGTATGGAGTTTAAGACAGAGTCCTTGACTCCTCACTGTGCTCTGGAAAACTGGCCCTTGACT
AGATGGATGCAGTATCTCCGAGAGGGATACACGGTGTGTGTGGATTGTCAGCCTCCAGCTATGAACTCTGTGAGCCTTCGTTGTTCTGGA
GATGGCCTGGACTCCGATGGAAATCAGACTCTCCATTGGCAAGCAATTGGTAATCCTCGGTGTCAAGGAACTTGGAAAAAAGTTCGGCGA
GTAGACCAGTGTTCTTGTCCAGCTGTTCACAGTTTTATTTTTATATAGATGGTGATATAAATATTTCCAAATGCATTTGTAAACATTCTA
AATATTCTCAAGTCATGTTCAATGTTTCCTAAACCTTCAATTTTGGCCAAAGTCCCCAAACACATCATTGCCACACTCTGAAGTAGAGAA
AGAAAATTTAGGGGCCAGTTCTCAAGGAACACAGGTCCTTTATTTTTATTTTAACTAAGTTGAAGACCCACTCAAAAAGCTCTTGTGGTT
TTATGTTCTTGACCTTTCAACTGGAGTCCTCTCATTCAGCAGGTGGCCCGTGAGACACAGAATACATGTCTGTTTGCTAAAGTAAAATTA
CTGTAACTCAGTCCGATTATTGGTGACGGAAGTGTCATTTAAGGGGATCTATGTTTTGAACCTTGCAGTCTATTTTATAATCTTTTAAAA
GTTTCTCACTTTAAAACATGTATACAGGTATGCACACTCTACACATATATTTCCATATATTTAATATTCCATAAATTCTGAAATAATTTC
AAGCAAATTATCACAAATAATTTTTCCACAGGGCAAATTATTTAAAATTTTAGTAAGCATTCTGTAATGAAAAACCAAGTTATACTAAAA
ACATTTTTTGAAGAAGAAATTTTTTTTTTGCTTAAGAAGTGAAAGGATCAAATGCTCATTGTAGGTCAATGGGAGTTCTTTTAAATGTTA
TAATTTTCATGAAAAGAAATGTTGACACCAGTGAATGAAACAATTGCTTTCATTCTGAAAATTCTACCACCATTTGCATCTAAGATTATT
TCCAAGGCTTAAAGCCTGAAGCTGAATAAAATAATCTTTCAGAGTCCAGCTTCAAGTTTAGTTGATGTAAGCTCACTATTTTTTTCCTAC
CGCATGCATTTTCTAATGTTTGGGGTGGATGGTGTGTCGGTTATGGAAGGCATAGACGTCATTACAGGTGCTACGATCTCACACACACAC
AAGGAAATGTTAGTCTCCTTATTTTATGATTGGAAAATCAATGACCTAGAGGCAAAATGGCATGTTTAAGGACCTGGGATGACAAGTCAT
TCTGCAGTCAGCCACAGAGCCAAATTTGGACTCCTCAACCAGAACTCCATGAAAAGCCTGACTTTGCCAAACACTGTGCTGGAAAAGCTA
AGCCCCTTTCATTTGTGAAGTAAATTTTAAATTCAAGATATTTAGTTTAGAGAATTGAGTCTTGAGATGTAAACTACATGAGATTTCTTT
GGTTTCAATTGAATAATATTCACTAACAAATGATTTACTAAAATACGTATTTCTTGGTCCTTATCATGTAATGACAGATTCACAACAGCA
ATAAGGATGGAGATTTCCCCAATAATTAATAACACCGAGAGTAGCAATATTTTTTACTGTATTTTCATTTAATTGTCAAAGTTGTTTTTG
TGGAAAATTAAATTCTTCAGAAATTAATAATAAAATATGTGAGTCTCATCAAGGCTAGCAACTTTAAGTCAGTATTAACATTTTCATACT
GTTTCTAACATTTATTAAGCTAGATTTTTGAAGCTATGTCTGGGTAATTTCCAATGTTACTTAAAAGTTTTTTTTTCTTTGAGACAGAGT
CTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCCCCATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTTCTGCCTCA
GCCTCCCAAGTAGCTGGGACTACAGGCGCCGTCATCACGCCTGGCTAATTTTTTGTTTTTTTTTTTTAGTAGAGACAGGGTTTCACTGTG
TTAGCCAGGGTGGTCTCGATCTCCTGACCTCGTGATCCACCCACCTCGGCCTCCCAAGGTGCTGGGATTATGGGCGTGAGCCACTGCGCC
TGGCCTGTTACTTAAAATTTTTATACTAGTAAATAAACTTTTTGTTCACATTTATAAAAGCTCTATATTTGTTTGACTAGAAAATAACCC
AAATTTTCTGGACCAGTCAGAGAATGATAAAATTTCACCAAAAATAAAACAAAAAAATCCTTCAGAACTGATAGGTATAGGTACAACAAC
TACTAATAGCAATAAAGCAATGGTGCTTTTATAGTTCCGATATGTGTTATAACATTTAACATAATTGAGGTGTATAAAATAAATTTTTCA
CCTTATGCATTTAATTTTTGGTGGATGACCAGTAATTGCTTTCTTATTGAAGTTAAATTTTTGTTATTTCTATTCTTGAGAAAATTTTAT
GGGCTAGAGGAGTTAACTGTTAAATAACAGTTTTGAAAAGCTTGTTATTAATTTTAGCAAAGCCCAAGGGAAATAGTTCAGAACTGAAAC
ATGTAGTCCAAGTGATGAATGAAAAACCAAAAGTTTTTATTTTCAAATTTAAAAATCAAAGTATATAAGACCTCTTGGCACTCTTTTTTA
ATAAGTACCTTAGTCTTAGGGCCCTATCCCCAGGCACTCTAAAAAGATTTACGAACTCTAAAATCCCTTAATAGACTGATTTTCAAAAGT
GCTCATGGAAAATAATTCGAACAAAAATAAATACAGCCACCAGGAAAGAAGGGAAAAGAAGCAAGGGATAATGGCCATTTTTGAAGAGAA
AAGTGAAAAACAAGTGAAGGAAAAAAAGAATAGAAAAAGGAATAAGGTAACTATAATCACAGTATTCTTTTTGGAGTTTTGCTTTGGTTT
TTATTCGAGAATGTTACAATTAAGCATAAACCGCAACAGCAATAATTTAAAGTGTTTGGTTATCATCTGGCATAAAAATTTCAGTTAGCT

>In-frame_ENST00000345512_ENST00000297354_TCGA-78-7153-01A_PTPRU_chr1_29563229_+_SBSPON_chr8_73984105_length(amino acids)=152AA_start in transcript=129_stop in transcript=587
MARAQALVLALTFQLCAPETETPAVPAFITTSAFNKERTRQATSPHWSTHTEDAGYCMEFKTESLTPHCALENWPLTRWMQYLREGYTVC

--------------------------------------------------------------
>In-frame_ENST00000373779_ENST00000297354_TCGA-78-7153-01A_PTPRU_chr1_29563229_+_SBSPON_chr8_73984105_length(transcript)=3389nt_BP=202nt
GGCGCCAGTCCCGCTCCGCGCCGCGCCGCTCCGCTCCGGCTCGGGCTCCGGCTCGCCTCGGGCTGGGCTCGGGCTCCGGGGGCGGCGTCC
CCCGCGCCGGGCCCCGGGACGGGCGGCGACGCTCCAACCATGGCCCGTGCCCAGGCGCTCGTGCTGGCACTCACCTTCCAGCTCTGCGCG
CCGGAGACCGAGACTCCGGCAGTTCCTGCCTTTATAACTACCTCTGCATTCAACAAGGAGAGAACACGACAAGCTACGTCTCCACACTGG
TCTACACACACAGAGGATGCTGGATACTGTATGGAGTTTAAGACAGAGTCCTTGACTCCTCACTGTGCTCTGGAAAACTGGCCCTTGACT
AGATGGATGCAGTATCTCCGAGAGGGATACACGGTGTGTGTGGATTGTCAGCCTCCAGCTATGAACTCTGTGAGCCTTCGTTGTTCTGGA
GATGGCCTGGACTCCGATGGAAATCAGACTCTCCATTGGCAAGCAATTGGTAATCCTCGGTGTCAAGGAACTTGGAAAAAAGTTCGGCGA
GTAGACCAGTGTTCTTGTCCAGCTGTTCACAGTTTTATTTTTATATAGATGGTGATATAAATATTTCCAAATGCATTTGTAAACATTCTA
AATATTCTCAAGTCATGTTCAATGTTTCCTAAACCTTCAATTTTGGCCAAAGTCCCCAAACACATCATTGCCACACTCTGAAGTAGAGAA
AGAAAATTTAGGGGCCAGTTCTCAAGGAACACAGGTCCTTTATTTTTATTTTAACTAAGTTGAAGACCCACTCAAAAAGCTCTTGTGGTT
TTATGTTCTTGACCTTTCAACTGGAGTCCTCTCATTCAGCAGGTGGCCCGTGAGACACAGAATACATGTCTGTTTGCTAAAGTAAAATTA
CTGTAACTCAGTCCGATTATTGGTGACGGAAGTGTCATTTAAGGGGATCTATGTTTTGAACCTTGCAGTCTATTTTATAATCTTTTAAAA
GTTTCTCACTTTAAAACATGTATACAGGTATGCACACTCTACACATATATTTCCATATATTTAATATTCCATAAATTCTGAAATAATTTC
AAGCAAATTATCACAAATAATTTTTCCACAGGGCAAATTATTTAAAATTTTAGTAAGCATTCTGTAATGAAAAACCAAGTTATACTAAAA
ACATTTTTTGAAGAAGAAATTTTTTTTTTGCTTAAGAAGTGAAAGGATCAAATGCTCATTGTAGGTCAATGGGAGTTCTTTTAAATGTTA
TAATTTTCATGAAAAGAAATGTTGACACCAGTGAATGAAACAATTGCTTTCATTCTGAAAATTCTACCACCATTTGCATCTAAGATTATT
TCCAAGGCTTAAAGCCTGAAGCTGAATAAAATAATCTTTCAGAGTCCAGCTTCAAGTTTAGTTGATGTAAGCTCACTATTTTTTTCCTAC
CGCATGCATTTTCTAATGTTTGGGGTGGATGGTGTGTCGGTTATGGAAGGCATAGACGTCATTACAGGTGCTACGATCTCACACACACAC
AAGGAAATGTTAGTCTCCTTATTTTATGATTGGAAAATCAATGACCTAGAGGCAAAATGGCATGTTTAAGGACCTGGGATGACAAGTCAT
TCTGCAGTCAGCCACAGAGCCAAATTTGGACTCCTCAACCAGAACTCCATGAAAAGCCTGACTTTGCCAAACACTGTGCTGGAAAAGCTA
AGCCCCTTTCATTTGTGAAGTAAATTTTAAATTCAAGATATTTAGTTTAGAGAATTGAGTCTTGAGATGTAAACTACATGAGATTTCTTT
GGTTTCAATTGAATAATATTCACTAACAAATGATTTACTAAAATACGTATTTCTTGGTCCTTATCATGTAATGACAGATTCACAACAGCA
ATAAGGATGGAGATTTCCCCAATAATTAATAACACCGAGAGTAGCAATATTTTTTACTGTATTTTCATTTAATTGTCAAAGTTGTTTTTG
TGGAAAATTAAATTCTTCAGAAATTAATAATAAAATATGTGAGTCTCATCAAGGCTAGCAACTTTAAGTCAGTATTAACATTTTCATACT
GTTTCTAACATTTATTAAGCTAGATTTTTGAAGCTATGTCTGGGTAATTTCCAATGTTACTTAAAAGTTTTTTTTTCTTTGAGACAGAGT
CTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCCCCATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTTCTGCCTCA
GCCTCCCAAGTAGCTGGGACTACAGGCGCCGTCATCACGCCTGGCTAATTTTTTGTTTTTTTTTTTTAGTAGAGACAGGGTTTCACTGTG
TTAGCCAGGGTGGTCTCGATCTCCTGACCTCGTGATCCACCCACCTCGGCCTCCCAAGGTGCTGGGATTATGGGCGTGAGCCACTGCGCC
TGGCCTGTTACTTAAAATTTTTATACTAGTAAATAAACTTTTTGTTCACATTTATAAAAGCTCTATATTTGTTTGACTAGAAAATAACCC
AAATTTTCTGGACCAGTCAGAGAATGATAAAATTTCACCAAAAATAAAACAAAAAAATCCTTCAGAACTGATAGGTATAGGTACAACAAC
TACTAATAGCAATAAAGCAATGGTGCTTTTATAGTTCCGATATGTGTTATAACATTTAACATAATTGAGGTGTATAAAATAAATTTTTCA
CCTTATGCATTTAATTTTTGGTGGATGACCAGTAATTGCTTTCTTATTGAAGTTAAATTTTTGTTATTTCTATTCTTGAGAAAATTTTAT
GGGCTAGAGGAGTTAACTGTTAAATAACAGTTTTGAAAAGCTTGTTATTAATTTTAGCAAAGCCCAAGGGAAATAGTTCAGAACTGAAAC
ATGTAGTCCAAGTGATGAATGAAAAACCAAAAGTTTTTATTTTCAAATTTAAAAATCAAAGTATATAAGACCTCTTGGCACTCTTTTTTA
ATAAGTACCTTAGTCTTAGGGCCCTATCCCCAGGCACTCTAAAAAGATTTACGAACTCTAAAATCCCTTAATAGACTGATTTTCAAAAGT
GCTCATGGAAAATAATTCGAACAAAAATAAATACAGCCACCAGGAAAGAAGGGAAAAGAAGCAAGGGATAATGGCCATTTTTGAAGAGAA
AAGTGAAAAACAAGTGAAGGAAAAAAAGAATAGAAAAAGGAATAAGGTAACTATAATCACAGTATTCTTTTTGGAGTTTTGCTTTGGTTT
TTATTCGAGAATGTTACAATTAAGCATAAACCGCAACAGCAATAATTTAAAGTGTTTGGTTATCATCTGGCATAAAAATTTCAGTTAGCT

>In-frame_ENST00000373779_ENST00000297354_TCGA-78-7153-01A_PTPRU_chr1_29563229_+_SBSPON_chr8_73984105_length(amino acids)=152AA_start in transcript=129_stop in transcript=587
MARAQALVLALTFQLCAPETETPAVPAFITTSAFNKERTRQATSPHWSTHTEDAGYCMEFKTESLTPHCALENWPLTRWMQYLREGYTVC

--------------------------------------------------------------
>In-frame_ENST00000356870_ENST00000297354_TCGA-78-7153-01A_PTPRU_chr1_29563229_+_SBSPON_chr8_73984105_length(transcript)=3370nt_BP=183nt
GCCGCGCCGCTCCGCTCCGGCTCGGGCTCCGGCTCGCCTCGGGCTGGGCTCGGGCTCCGGGGGCGGCGTCCCCCGCGCCGGGCCCCGGGA
CGGGCGGCGACGCTCCAACCATGGCCCGTGCCCAGGCGCTCGTGCTGGCACTCACCTTCCAGCTCTGCGCGCCGGAGACCGAGACTCCGG
CAGTTCCTGCCTTTATAACTACCTCTGCATTCAACAAGGAGAGAACACGACAAGCTACGTCTCCACACTGGTCTACACACACAGAGGATG
CTGGATACTGTATGGAGTTTAAGACAGAGTCCTTGACTCCTCACTGTGCTCTGGAAAACTGGCCCTTGACTAGATGGATGCAGTATCTCC
GAGAGGGATACACGGTGTGTGTGGATTGTCAGCCTCCAGCTATGAACTCTGTGAGCCTTCGTTGTTCTGGAGATGGCCTGGACTCCGATG
GAAATCAGACTCTCCATTGGCAAGCAATTGGTAATCCTCGGTGTCAAGGAACTTGGAAAAAAGTTCGGCGAGTAGACCAGTGTTCTTGTC
CAGCTGTTCACAGTTTTATTTTTATATAGATGGTGATATAAATATTTCCAAATGCATTTGTAAACATTCTAAATATTCTCAAGTCATGTT
CAATGTTTCCTAAACCTTCAATTTTGGCCAAAGTCCCCAAACACATCATTGCCACACTCTGAAGTAGAGAAAGAAAATTTAGGGGCCAGT
TCTCAAGGAACACAGGTCCTTTATTTTTATTTTAACTAAGTTGAAGACCCACTCAAAAAGCTCTTGTGGTTTTATGTTCTTGACCTTTCA
ACTGGAGTCCTCTCATTCAGCAGGTGGCCCGTGAGACACAGAATACATGTCTGTTTGCTAAAGTAAAATTACTGTAACTCAGTCCGATTA
TTGGTGACGGAAGTGTCATTTAAGGGGATCTATGTTTTGAACCTTGCAGTCTATTTTATAATCTTTTAAAAGTTTCTCACTTTAAAACAT
GTATACAGGTATGCACACTCTACACATATATTTCCATATATTTAATATTCCATAAATTCTGAAATAATTTCAAGCAAATTATCACAAATA
ATTTTTCCACAGGGCAAATTATTTAAAATTTTAGTAAGCATTCTGTAATGAAAAACCAAGTTATACTAAAAACATTTTTTGAAGAAGAAA
TTTTTTTTTTGCTTAAGAAGTGAAAGGATCAAATGCTCATTGTAGGTCAATGGGAGTTCTTTTAAATGTTATAATTTTCATGAAAAGAAA
TGTTGACACCAGTGAATGAAACAATTGCTTTCATTCTGAAAATTCTACCACCATTTGCATCTAAGATTATTTCCAAGGCTTAAAGCCTGA
AGCTGAATAAAATAATCTTTCAGAGTCCAGCTTCAAGTTTAGTTGATGTAAGCTCACTATTTTTTTCCTACCGCATGCATTTTCTAATGT
TTGGGGTGGATGGTGTGTCGGTTATGGAAGGCATAGACGTCATTACAGGTGCTACGATCTCACACACACACAAGGAAATGTTAGTCTCCT
TATTTTATGATTGGAAAATCAATGACCTAGAGGCAAAATGGCATGTTTAAGGACCTGGGATGACAAGTCATTCTGCAGTCAGCCACAGAG
CCAAATTTGGACTCCTCAACCAGAACTCCATGAAAAGCCTGACTTTGCCAAACACTGTGCTGGAAAAGCTAAGCCCCTTTCATTTGTGAA
GTAAATTTTAAATTCAAGATATTTAGTTTAGAGAATTGAGTCTTGAGATGTAAACTACATGAGATTTCTTTGGTTTCAATTGAATAATAT
TCACTAACAAATGATTTACTAAAATACGTATTTCTTGGTCCTTATCATGTAATGACAGATTCACAACAGCAATAAGGATGGAGATTTCCC
CAATAATTAATAACACCGAGAGTAGCAATATTTTTTACTGTATTTTCATTTAATTGTCAAAGTTGTTTTTGTGGAAAATTAAATTCTTCA
GAAATTAATAATAAAATATGTGAGTCTCATCAAGGCTAGCAACTTTAAGTCAGTATTAACATTTTCATACTGTTTCTAACATTTATTAAG
CTAGATTTTTGAAGCTATGTCTGGGTAATTTCCAATGTTACTTAAAAGTTTTTTTTTCTTTGAGACAGAGTCTCACTCTGTTGCCCAGGC
TGGAGTGCAGTGGCCCCATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTTCTGCCTCAGCCTCCCAAGTAGCTGGGA
CTACAGGCGCCGTCATCACGCCTGGCTAATTTTTTGTTTTTTTTTTTTAGTAGAGACAGGGTTTCACTGTGTTAGCCAGGGTGGTCTCGA
TCTCCTGACCTCGTGATCCACCCACCTCGGCCTCCCAAGGTGCTGGGATTATGGGCGTGAGCCACTGCGCCTGGCCTGTTACTTAAAATT
TTTATACTAGTAAATAAACTTTTTGTTCACATTTATAAAAGCTCTATATTTGTTTGACTAGAAAATAACCCAAATTTTCTGGACCAGTCA
GAGAATGATAAAATTTCACCAAAAATAAAACAAAAAAATCCTTCAGAACTGATAGGTATAGGTACAACAACTACTAATAGCAATAAAGCA
ATGGTGCTTTTATAGTTCCGATATGTGTTATAACATTTAACATAATTGAGGTGTATAAAATAAATTTTTCACCTTATGCATTTAATTTTT
GGTGGATGACCAGTAATTGCTTTCTTATTGAAGTTAAATTTTTGTTATTTCTATTCTTGAGAAAATTTTATGGGCTAGAGGAGTTAACTG
TTAAATAACAGTTTTGAAAAGCTTGTTATTAATTTTAGCAAAGCCCAAGGGAAATAGTTCAGAACTGAAACATGTAGTCCAAGTGATGAA
TGAAAAACCAAAAGTTTTTATTTTCAAATTTAAAAATCAAAGTATATAAGACCTCTTGGCACTCTTTTTTAATAAGTACCTTAGTCTTAG
GGCCCTATCCCCAGGCACTCTAAAAAGATTTACGAACTCTAAAATCCCTTAATAGACTGATTTTCAAAAGTGCTCATGGAAAATAATTCG
AACAAAAATAAATACAGCCACCAGGAAAGAAGGGAAAAGAAGCAAGGGATAATGGCCATTTTTGAAGAGAAAAGTGAAAAACAAGTGAAG
GAAAAAAAGAATAGAAAAAGGAATAAGGTAACTATAATCACAGTATTCTTTTTGGAGTTTTGCTTTGGTTTTTATTCGAGAATGTTACAA
TTAAGCATAAACCGCAACAGCAATAATTTAAAGTGTTTGGTTATCATCTGGCATAAAAATTTCAGTTAGCTATCTTTTCTAGATGTGCAC

>In-frame_ENST00000356870_ENST00000297354_TCGA-78-7153-01A_PTPRU_chr1_29563229_+_SBSPON_chr8_73984105_length(amino acids)=152AA_start in transcript=110_stop in transcript=568
MARAQALVLALTFQLCAPETETPAVPAFITTSAFNKERTRQATSPHWSTHTEDAGYCMEFKTESLTPHCALENWPLTRWMQYLREGYTVC

--------------------------------------------------------------
>In-frame_ENST00000323874_ENST00000297354_TCGA-78-7153-01A_PTPRU_chr1_29563229_+_SBSPON_chr8_73984105_length(transcript)=3370nt_BP=183nt
GCCGCGCCGCTCCGCTCCGGCTCGGGCTCCGGCTCGCCTCGGGCTGGGCTCGGGCTCCGGGGGCGGCGTCCCCCGCGCCGGGCCCCGGGA
CGGGCGGCGACGCTCCAACCATGGCCCGTGCCCAGGCGCTCGTGCTGGCACTCACCTTCCAGCTCTGCGCGCCGGAGACCGAGACTCCGG
CAGTTCCTGCCTTTATAACTACCTCTGCATTCAACAAGGAGAGAACACGACAAGCTACGTCTCCACACTGGTCTACACACACAGAGGATG
CTGGATACTGTATGGAGTTTAAGACAGAGTCCTTGACTCCTCACTGTGCTCTGGAAAACTGGCCCTTGACTAGATGGATGCAGTATCTCC
GAGAGGGATACACGGTGTGTGTGGATTGTCAGCCTCCAGCTATGAACTCTGTGAGCCTTCGTTGTTCTGGAGATGGCCTGGACTCCGATG
GAAATCAGACTCTCCATTGGCAAGCAATTGGTAATCCTCGGTGTCAAGGAACTTGGAAAAAAGTTCGGCGAGTAGACCAGTGTTCTTGTC
CAGCTGTTCACAGTTTTATTTTTATATAGATGGTGATATAAATATTTCCAAATGCATTTGTAAACATTCTAAATATTCTCAAGTCATGTT
CAATGTTTCCTAAACCTTCAATTTTGGCCAAAGTCCCCAAACACATCATTGCCACACTCTGAAGTAGAGAAAGAAAATTTAGGGGCCAGT
TCTCAAGGAACACAGGTCCTTTATTTTTATTTTAACTAAGTTGAAGACCCACTCAAAAAGCTCTTGTGGTTTTATGTTCTTGACCTTTCA
ACTGGAGTCCTCTCATTCAGCAGGTGGCCCGTGAGACACAGAATACATGTCTGTTTGCTAAAGTAAAATTACTGTAACTCAGTCCGATTA
TTGGTGACGGAAGTGTCATTTAAGGGGATCTATGTTTTGAACCTTGCAGTCTATTTTATAATCTTTTAAAAGTTTCTCACTTTAAAACAT
GTATACAGGTATGCACACTCTACACATATATTTCCATATATTTAATATTCCATAAATTCTGAAATAATTTCAAGCAAATTATCACAAATA
ATTTTTCCACAGGGCAAATTATTTAAAATTTTAGTAAGCATTCTGTAATGAAAAACCAAGTTATACTAAAAACATTTTTTGAAGAAGAAA
TTTTTTTTTTGCTTAAGAAGTGAAAGGATCAAATGCTCATTGTAGGTCAATGGGAGTTCTTTTAAATGTTATAATTTTCATGAAAAGAAA
TGTTGACACCAGTGAATGAAACAATTGCTTTCATTCTGAAAATTCTACCACCATTTGCATCTAAGATTATTTCCAAGGCTTAAAGCCTGA
AGCTGAATAAAATAATCTTTCAGAGTCCAGCTTCAAGTTTAGTTGATGTAAGCTCACTATTTTTTTCCTACCGCATGCATTTTCTAATGT
TTGGGGTGGATGGTGTGTCGGTTATGGAAGGCATAGACGTCATTACAGGTGCTACGATCTCACACACACACAAGGAAATGTTAGTCTCCT
TATTTTATGATTGGAAAATCAATGACCTAGAGGCAAAATGGCATGTTTAAGGACCTGGGATGACAAGTCATTCTGCAGTCAGCCACAGAG
CCAAATTTGGACTCCTCAACCAGAACTCCATGAAAAGCCTGACTTTGCCAAACACTGTGCTGGAAAAGCTAAGCCCCTTTCATTTGTGAA
GTAAATTTTAAATTCAAGATATTTAGTTTAGAGAATTGAGTCTTGAGATGTAAACTACATGAGATTTCTTTGGTTTCAATTGAATAATAT
TCACTAACAAATGATTTACTAAAATACGTATTTCTTGGTCCTTATCATGTAATGACAGATTCACAACAGCAATAAGGATGGAGATTTCCC
CAATAATTAATAACACCGAGAGTAGCAATATTTTTTACTGTATTTTCATTTAATTGTCAAAGTTGTTTTTGTGGAAAATTAAATTCTTCA
GAAATTAATAATAAAATATGTGAGTCTCATCAAGGCTAGCAACTTTAAGTCAGTATTAACATTTTCATACTGTTTCTAACATTTATTAAG
CTAGATTTTTGAAGCTATGTCTGGGTAATTTCCAATGTTACTTAAAAGTTTTTTTTTCTTTGAGACAGAGTCTCACTCTGTTGCCCAGGC
TGGAGTGCAGTGGCCCCATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTTCTGCCTCAGCCTCCCAAGTAGCTGGGA
CTACAGGCGCCGTCATCACGCCTGGCTAATTTTTTGTTTTTTTTTTTTAGTAGAGACAGGGTTTCACTGTGTTAGCCAGGGTGGTCTCGA
TCTCCTGACCTCGTGATCCACCCACCTCGGCCTCCCAAGGTGCTGGGATTATGGGCGTGAGCCACTGCGCCTGGCCTGTTACTTAAAATT
TTTATACTAGTAAATAAACTTTTTGTTCACATTTATAAAAGCTCTATATTTGTTTGACTAGAAAATAACCCAAATTTTCTGGACCAGTCA
GAGAATGATAAAATTTCACCAAAAATAAAACAAAAAAATCCTTCAGAACTGATAGGTATAGGTACAACAACTACTAATAGCAATAAAGCA
ATGGTGCTTTTATAGTTCCGATATGTGTTATAACATTTAACATAATTGAGGTGTATAAAATAAATTTTTCACCTTATGCATTTAATTTTT
GGTGGATGACCAGTAATTGCTTTCTTATTGAAGTTAAATTTTTGTTATTTCTATTCTTGAGAAAATTTTATGGGCTAGAGGAGTTAACTG
TTAAATAACAGTTTTGAAAAGCTTGTTATTAATTTTAGCAAAGCCCAAGGGAAATAGTTCAGAACTGAAACATGTAGTCCAAGTGATGAA
TGAAAAACCAAAAGTTTTTATTTTCAAATTTAAAAATCAAAGTATATAAGACCTCTTGGCACTCTTTTTTAATAAGTACCTTAGTCTTAG
GGCCCTATCCCCAGGCACTCTAAAAAGATTTACGAACTCTAAAATCCCTTAATAGACTGATTTTCAAAAGTGCTCATGGAAAATAATTCG
AACAAAAATAAATACAGCCACCAGGAAAGAAGGGAAAAGAAGCAAGGGATAATGGCCATTTTTGAAGAGAAAAGTGAAAAACAAGTGAAG
GAAAAAAAGAATAGAAAAAGGAATAAGGTAACTATAATCACAGTATTCTTTTTGGAGTTTTGCTTTGGTTTTTATTCGAGAATGTTACAA
TTAAGCATAAACCGCAACAGCAATAATTTAAAGTGTTTGGTTATCATCTGGCATAAAAATTTCAGTTAGCTATCTTTTCTAGATGTGCAC

>In-frame_ENST00000323874_ENST00000297354_TCGA-78-7153-01A_PTPRU_chr1_29563229_+_SBSPON_chr8_73984105_length(amino acids)=152AA_start in transcript=110_stop in transcript=568
MARAQALVLALTFQLCAPETETPAVPAFITTSAFNKERTRQATSPHWSTHTEDAGYCMEFKTESLTPHCALENWPLTRWMQYLREGYTVC

--------------------------------------------------------------
>In-frame_ENST00000428026_ENST00000297354_TCGA-78-7153-01A_PTPRU_chr1_29563229_+_SBSPON_chr8_73984105_length(transcript)=3356nt_BP=169nt
CTCCGGCTCGGGCTCCGGCTCGCCTCGGGCTGGGCTCGGGCTCCGGGGGCGGCGTCCCCCGCGCCGGGCCCCGGGACGGGCGGCGACGCT
CCAACCATGGCCCGTGCCCAGGCGCTCGTGCTGGCACTCACCTTCCAGCTCTGCGCGCCGGAGACCGAGACTCCGGCAGTTCCTGCCTTT
ATAACTACCTCTGCATTCAACAAGGAGAGAACACGACAAGCTACGTCTCCACACTGGTCTACACACACAGAGGATGCTGGATACTGTATG
GAGTTTAAGACAGAGTCCTTGACTCCTCACTGTGCTCTGGAAAACTGGCCCTTGACTAGATGGATGCAGTATCTCCGAGAGGGATACACG
GTGTGTGTGGATTGTCAGCCTCCAGCTATGAACTCTGTGAGCCTTCGTTGTTCTGGAGATGGCCTGGACTCCGATGGAAATCAGACTCTC
CATTGGCAAGCAATTGGTAATCCTCGGTGTCAAGGAACTTGGAAAAAAGTTCGGCGAGTAGACCAGTGTTCTTGTCCAGCTGTTCACAGT
TTTATTTTTATATAGATGGTGATATAAATATTTCCAAATGCATTTGTAAACATTCTAAATATTCTCAAGTCATGTTCAATGTTTCCTAAA
CCTTCAATTTTGGCCAAAGTCCCCAAACACATCATTGCCACACTCTGAAGTAGAGAAAGAAAATTTAGGGGCCAGTTCTCAAGGAACACA
GGTCCTTTATTTTTATTTTAACTAAGTTGAAGACCCACTCAAAAAGCTCTTGTGGTTTTATGTTCTTGACCTTTCAACTGGAGTCCTCTC
ATTCAGCAGGTGGCCCGTGAGACACAGAATACATGTCTGTTTGCTAAAGTAAAATTACTGTAACTCAGTCCGATTATTGGTGACGGAAGT
GTCATTTAAGGGGATCTATGTTTTGAACCTTGCAGTCTATTTTATAATCTTTTAAAAGTTTCTCACTTTAAAACATGTATACAGGTATGC
ACACTCTACACATATATTTCCATATATTTAATATTCCATAAATTCTGAAATAATTTCAAGCAAATTATCACAAATAATTTTTCCACAGGG
CAAATTATTTAAAATTTTAGTAAGCATTCTGTAATGAAAAACCAAGTTATACTAAAAACATTTTTTGAAGAAGAAATTTTTTTTTTGCTT
AAGAAGTGAAAGGATCAAATGCTCATTGTAGGTCAATGGGAGTTCTTTTAAATGTTATAATTTTCATGAAAAGAAATGTTGACACCAGTG
AATGAAACAATTGCTTTCATTCTGAAAATTCTACCACCATTTGCATCTAAGATTATTTCCAAGGCTTAAAGCCTGAAGCTGAATAAAATA
ATCTTTCAGAGTCCAGCTTCAAGTTTAGTTGATGTAAGCTCACTATTTTTTTCCTACCGCATGCATTTTCTAATGTTTGGGGTGGATGGT
GTGTCGGTTATGGAAGGCATAGACGTCATTACAGGTGCTACGATCTCACACACACACAAGGAAATGTTAGTCTCCTTATTTTATGATTGG
AAAATCAATGACCTAGAGGCAAAATGGCATGTTTAAGGACCTGGGATGACAAGTCATTCTGCAGTCAGCCACAGAGCCAAATTTGGACTC
CTCAACCAGAACTCCATGAAAAGCCTGACTTTGCCAAACACTGTGCTGGAAAAGCTAAGCCCCTTTCATTTGTGAAGTAAATTTTAAATT
CAAGATATTTAGTTTAGAGAATTGAGTCTTGAGATGTAAACTACATGAGATTTCTTTGGTTTCAATTGAATAATATTCACTAACAAATGA
TTTACTAAAATACGTATTTCTTGGTCCTTATCATGTAATGACAGATTCACAACAGCAATAAGGATGGAGATTTCCCCAATAATTAATAAC
ACCGAGAGTAGCAATATTTTTTACTGTATTTTCATTTAATTGTCAAAGTTGTTTTTGTGGAAAATTAAATTCTTCAGAAATTAATAATAA
AATATGTGAGTCTCATCAAGGCTAGCAACTTTAAGTCAGTATTAACATTTTCATACTGTTTCTAACATTTATTAAGCTAGATTTTTGAAG
CTATGTCTGGGTAATTTCCAATGTTACTTAAAAGTTTTTTTTTCTTTGAGACAGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGC
CCCATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTTCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCGCCGTC
ATCACGCCTGGCTAATTTTTTGTTTTTTTTTTTTAGTAGAGACAGGGTTTCACTGTGTTAGCCAGGGTGGTCTCGATCTCCTGACCTCGT
GATCCACCCACCTCGGCCTCCCAAGGTGCTGGGATTATGGGCGTGAGCCACTGCGCCTGGCCTGTTACTTAAAATTTTTATACTAGTAAA
TAAACTTTTTGTTCACATTTATAAAAGCTCTATATTTGTTTGACTAGAAAATAACCCAAATTTTCTGGACCAGTCAGAGAATGATAAAAT
TTCACCAAAAATAAAACAAAAAAATCCTTCAGAACTGATAGGTATAGGTACAACAACTACTAATAGCAATAAAGCAATGGTGCTTTTATA
GTTCCGATATGTGTTATAACATTTAACATAATTGAGGTGTATAAAATAAATTTTTCACCTTATGCATTTAATTTTTGGTGGATGACCAGT
AATTGCTTTCTTATTGAAGTTAAATTTTTGTTATTTCTATTCTTGAGAAAATTTTATGGGCTAGAGGAGTTAACTGTTAAATAACAGTTT
TGAAAAGCTTGTTATTAATTTTAGCAAAGCCCAAGGGAAATAGTTCAGAACTGAAACATGTAGTCCAAGTGATGAATGAAAAACCAAAAG
TTTTTATTTTCAAATTTAAAAATCAAAGTATATAAGACCTCTTGGCACTCTTTTTTAATAAGTACCTTAGTCTTAGGGCCCTATCCCCAG
GCACTCTAAAAAGATTTACGAACTCTAAAATCCCTTAATAGACTGATTTTCAAAAGTGCTCATGGAAAATAATTCGAACAAAAATAAATA
CAGCCACCAGGAAAGAAGGGAAAAGAAGCAAGGGATAATGGCCATTTTTGAAGAGAAAAGTGAAAAACAAGTGAAGGAAAAAAAGAATAG
AAAAAGGAATAAGGTAACTATAATCACAGTATTCTTTTTGGAGTTTTGCTTTGGTTTTTATTCGAGAATGTTACAATTAAGCATAAACCG
CAACAGCAATAATTTAAAGTGTTTGGTTATCATCTGGCATAAAAATTTCAGTTAGCTATCTTTTCTAGATGTGCACAAAATTGATGTTAA

>In-frame_ENST00000428026_ENST00000297354_TCGA-78-7153-01A_PTPRU_chr1_29563229_+_SBSPON_chr8_73984105_length(amino acids)=152AA_start in transcript=96_stop in transcript=554
MARAQALVLALTFQLCAPETETPAVPAFITTSAFNKERTRQATSPHWSTHTEDAGYCMEFKTESLTPHCALENWPLTRWMQYLREGYTVC

--------------------------------------------------------------
>In-frame_ENST00000460170_ENST00000297354_TCGA-78-7153-01A_PTPRU_chr1_29563229_+_SBSPON_chr8_73984105_length(transcript)=3266nt_BP=79nt
CCAACCATGGCCCGTGCCCAGGCGCTCGTGCTGGCACTCACCTTCCAGCTCTGCGCGCCGGAGACCGAGACTCCGGCAGTTCCTGCCTTT
ATAACTACCTCTGCATTCAACAAGGAGAGAACACGACAAGCTACGTCTCCACACTGGTCTACACACACAGAGGATGCTGGATACTGTATG
GAGTTTAAGACAGAGTCCTTGACTCCTCACTGTGCTCTGGAAAACTGGCCCTTGACTAGATGGATGCAGTATCTCCGAGAGGGATACACG
GTGTGTGTGGATTGTCAGCCTCCAGCTATGAACTCTGTGAGCCTTCGTTGTTCTGGAGATGGCCTGGACTCCGATGGAAATCAGACTCTC
CATTGGCAAGCAATTGGTAATCCTCGGTGTCAAGGAACTTGGAAAAAAGTTCGGCGAGTAGACCAGTGTTCTTGTCCAGCTGTTCACAGT
TTTATTTTTATATAGATGGTGATATAAATATTTCCAAATGCATTTGTAAACATTCTAAATATTCTCAAGTCATGTTCAATGTTTCCTAAA
CCTTCAATTTTGGCCAAAGTCCCCAAACACATCATTGCCACACTCTGAAGTAGAGAAAGAAAATTTAGGGGCCAGTTCTCAAGGAACACA
GGTCCTTTATTTTTATTTTAACTAAGTTGAAGACCCACTCAAAAAGCTCTTGTGGTTTTATGTTCTTGACCTTTCAACTGGAGTCCTCTC
ATTCAGCAGGTGGCCCGTGAGACACAGAATACATGTCTGTTTGCTAAAGTAAAATTACTGTAACTCAGTCCGATTATTGGTGACGGAAGT
GTCATTTAAGGGGATCTATGTTTTGAACCTTGCAGTCTATTTTATAATCTTTTAAAAGTTTCTCACTTTAAAACATGTATACAGGTATGC
ACACTCTACACATATATTTCCATATATTTAATATTCCATAAATTCTGAAATAATTTCAAGCAAATTATCACAAATAATTTTTCCACAGGG
CAAATTATTTAAAATTTTAGTAAGCATTCTGTAATGAAAAACCAAGTTATACTAAAAACATTTTTTGAAGAAGAAATTTTTTTTTTGCTT
AAGAAGTGAAAGGATCAAATGCTCATTGTAGGTCAATGGGAGTTCTTTTAAATGTTATAATTTTCATGAAAAGAAATGTTGACACCAGTG
AATGAAACAATTGCTTTCATTCTGAAAATTCTACCACCATTTGCATCTAAGATTATTTCCAAGGCTTAAAGCCTGAAGCTGAATAAAATA
ATCTTTCAGAGTCCAGCTTCAAGTTTAGTTGATGTAAGCTCACTATTTTTTTCCTACCGCATGCATTTTCTAATGTTTGGGGTGGATGGT
GTGTCGGTTATGGAAGGCATAGACGTCATTACAGGTGCTACGATCTCACACACACACAAGGAAATGTTAGTCTCCTTATTTTATGATTGG
AAAATCAATGACCTAGAGGCAAAATGGCATGTTTAAGGACCTGGGATGACAAGTCATTCTGCAGTCAGCCACAGAGCCAAATTTGGACTC
CTCAACCAGAACTCCATGAAAAGCCTGACTTTGCCAAACACTGTGCTGGAAAAGCTAAGCCCCTTTCATTTGTGAAGTAAATTTTAAATT
CAAGATATTTAGTTTAGAGAATTGAGTCTTGAGATGTAAACTACATGAGATTTCTTTGGTTTCAATTGAATAATATTCACTAACAAATGA
TTTACTAAAATACGTATTTCTTGGTCCTTATCATGTAATGACAGATTCACAACAGCAATAAGGATGGAGATTTCCCCAATAATTAATAAC
ACCGAGAGTAGCAATATTTTTTACTGTATTTTCATTTAATTGTCAAAGTTGTTTTTGTGGAAAATTAAATTCTTCAGAAATTAATAATAA
AATATGTGAGTCTCATCAAGGCTAGCAACTTTAAGTCAGTATTAACATTTTCATACTGTTTCTAACATTTATTAAGCTAGATTTTTGAAG
CTATGTCTGGGTAATTTCCAATGTTACTTAAAAGTTTTTTTTTCTTTGAGACAGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGC
CCCATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTTCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCGCCGTC
ATCACGCCTGGCTAATTTTTTGTTTTTTTTTTTTAGTAGAGACAGGGTTTCACTGTGTTAGCCAGGGTGGTCTCGATCTCCTGACCTCGT
GATCCACCCACCTCGGCCTCCCAAGGTGCTGGGATTATGGGCGTGAGCCACTGCGCCTGGCCTGTTACTTAAAATTTTTATACTAGTAAA
TAAACTTTTTGTTCACATTTATAAAAGCTCTATATTTGTTTGACTAGAAAATAACCCAAATTTTCTGGACCAGTCAGAGAATGATAAAAT
TTCACCAAAAATAAAACAAAAAAATCCTTCAGAACTGATAGGTATAGGTACAACAACTACTAATAGCAATAAAGCAATGGTGCTTTTATA
GTTCCGATATGTGTTATAACATTTAACATAATTGAGGTGTATAAAATAAATTTTTCACCTTATGCATTTAATTTTTGGTGGATGACCAGT
AATTGCTTTCTTATTGAAGTTAAATTTTTGTTATTTCTATTCTTGAGAAAATTTTATGGGCTAGAGGAGTTAACTGTTAAATAACAGTTT
TGAAAAGCTTGTTATTAATTTTAGCAAAGCCCAAGGGAAATAGTTCAGAACTGAAACATGTAGTCCAAGTGATGAATGAAAAACCAAAAG
TTTTTATTTTCAAATTTAAAAATCAAAGTATATAAGACCTCTTGGCACTCTTTTTTAATAAGTACCTTAGTCTTAGGGCCCTATCCCCAG
GCACTCTAAAAAGATTTACGAACTCTAAAATCCCTTAATAGACTGATTTTCAAAAGTGCTCATGGAAAATAATTCGAACAAAAATAAATA
CAGCCACCAGGAAAGAAGGGAAAAGAAGCAAGGGATAATGGCCATTTTTGAAGAGAAAAGTGAAAAACAAGTGAAGGAAAAAAAGAATAG
AAAAAGGAATAAGGTAACTATAATCACAGTATTCTTTTTGGAGTTTTGCTTTGGTTTTTATTCGAGAATGTTACAATTAAGCATAAACCG
CAACAGCAATAATTTAAAGTGTTTGGTTATCATCTGGCATAAAAATTTCAGTTAGCTATCTTTTCTAGATGTGCACAAAATTGATGTTAA

>In-frame_ENST00000460170_ENST00000297354_TCGA-78-7153-01A_PTPRU_chr1_29563229_+_SBSPON_chr8_73984105_length(amino acids)=152AA_start in transcript=6_stop in transcript=464
MARAQALVLALTFQLCAPETETPAVPAFITTSAFNKERTRQATSPHWSTHTEDAGYCMEFKTESLTPHCALENWPLTRWMQYLREGYTVC

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Fusion Gene PPI Analysis for PTPRU-SBSPON


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PTPRU-SBSPON


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTPRU-SBSPON


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSBSPONC0019209Hepatomegaly1CTD_human