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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PTPRU-UBIAD1 (FusionGDB2 ID:70137)

Fusion Gene Summary for PTPRU-UBIAD1

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRU-UBIAD1
Fusion gene ID: 70137
HgeneTgene
Gene symbol

PTPRU

UBIAD1

Gene ID

10076

29914

Gene nameprotein tyrosine phosphatase receptor type UUbiA prenyltransferase domain containing 1
SynonymsFMI|PCP-2|PTP|PTP-J|PTP-PI|PTP-RO|PTPPSI|PTPRO|PTPU2|R-PTP-PSI|R-PTP-U|hPTP-JSCCD|TERE1
Cytomap

1p35.3

1p36.22

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase UPTP piReceptor protein tyrosine phosphatase hPTP-Jpancreatic carcinoma phosphatase 2pi R-PTP-Psiprotein-tyrosine phosphatase Jprotein-tyrosine phosphatase piprotein-tyrosine phosphatase receptor omicronrubiA prenyltransferase domain-containing protein 1transitional epithelia response proteintransitional epithelial response protein 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000345512, ENST00000373779, 
ENST00000356870, ENST00000323874, 
ENST00000428026, ENST00000460170, 
ENST00000415600, 		ENST00000376810, 
ENST00000376804, 
Fusion gene scores* DoF score8 X 6 X 7=3363 X 2 X 3=18
# samples 103
** MAII scorelog2(10/336*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PTPRU [Title/Abstract] AND UBIAD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPTPRU(29563229)-UBIAD1(11345701), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPRU

GO:0006470

protein dephosphorylation

12501215

HgenePTPRU

GO:0008285

negative regulation of cell proliferation

16574648

HgenePTPRU

GO:0030336

negative regulation of cell migration

12501215|16574648

HgenePTPRU

GO:0034394

protein localization to cell surface

16574648

HgenePTPRU

GO:0090090

negative regulation of canonical Wnt signaling pathway

16574648

HgenePTPRU

GO:2000049

positive regulation of cell-cell adhesion mediated by cadherin

16574648

TgeneUBIAD1

GO:0042371

vitamin K biosynthetic process

20953171


check buttonFusion gene breakpoints across PTPRU (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across UBIAD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-32-5222-01APTPRUchr1

29563229

+UBIAD1chr1

11345701

+
ChimerDB4GBMTCGA-32-5222-01APTPRUchr1

29563229

+UBIAD1chr1

11345701

+


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Fusion Gene ORF analysis for PTPRU-UBIAD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000345512ENST00000376810PTPRUchr1

29563229

+UBIAD1chr1

11345701

+
5CDS-intronENST00000345512ENST00000376804PTPRUchr1

29563229

+UBIAD1chr1

11345701

+
In-frameENST00000373779ENST00000376810PTPRUchr1

29563229

+UBIAD1chr1

11345701

+
5CDS-intronENST00000373779ENST00000376804PTPRUchr1

29563229

+UBIAD1chr1

11345701

+
In-frameENST00000356870ENST00000376810PTPRUchr1

29563229

+UBIAD1chr1

11345701

+
5CDS-intronENST00000356870ENST00000376804PTPRUchr1

29563229

+UBIAD1chr1

11345701

+
In-frameENST00000323874ENST00000376810PTPRUchr1

29563229

+UBIAD1chr1

11345701

+
5CDS-intronENST00000323874ENST00000376804PTPRUchr1

29563229

+UBIAD1chr1

11345701

+
In-frameENST00000428026ENST00000376810PTPRUchr1

29563229

+UBIAD1chr1

11345701

+
5CDS-intronENST00000428026ENST00000376804PTPRUchr1

29563229

+UBIAD1chr1

11345701

+
In-frameENST00000460170ENST00000376810PTPRUchr1

29563229

+UBIAD1chr1

11345701

+
5CDS-intronENST00000460170ENST00000376804PTPRUchr1

29563229

+UBIAD1chr1

11345701

+
intron-3CDSENST00000415600ENST00000376810PTPRUchr1

29563229

+UBIAD1chr1

11345701

+
intron-intronENST00000415600ENST00000376804PTPRUchr1

29563229

+UBIAD1chr1

11345701

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000345512PTPRUchr129563229+ENST00000376810UBIAD1chr111345701+2993202129689186
ENST00000373779PTPRUchr129563229+ENST00000376810UBIAD1chr111345701+2993202129689186
ENST00000356870PTPRUchr129563229+ENST00000376810UBIAD1chr111345701+2974183110670186
ENST00000323874PTPRUchr129563229+ENST00000376810UBIAD1chr111345701+2974183110670186
ENST00000428026PTPRUchr129563229+ENST00000376810UBIAD1chr111345701+296016996656186
ENST00000460170PTPRUchr129563229+ENST00000376810UBIAD1chr111345701+2870796566186

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000345512ENST00000376810PTPRUchr129563229+UBIAD1chr111345701+0.0042904380.99570954
ENST00000373779ENST00000376810PTPRUchr129563229+UBIAD1chr111345701+0.0042904380.99570954
ENST00000356870ENST00000376810PTPRUchr129563229+UBIAD1chr111345701+0.0045482610.99545175
ENST00000323874ENST00000376810PTPRUchr129563229+UBIAD1chr111345701+0.0045482610.99545175
ENST00000428026ENST00000376810PTPRUchr129563229+UBIAD1chr111345701+0.0041891580.99581087
ENST00000460170ENST00000376810PTPRUchr129563229+UBIAD1chr111345701+0.0058202740.9941797

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Fusion Genomic Features for PTPRU-UBIAD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PTPRUchr129563229+UBIAD1chr111345700+2.47E-091
PTPRUchr129563229+UBIAD1chr111345700+2.47E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PTPRU-UBIAD1


check button Go to

FGviewer for the breakpoints of chr1:29563229-chr1:11345701

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneUBIAD1chr1:29563229chr1:11345701ENST0000037680402134_1540180.0TransmembraneHelical
TgeneUBIAD1chr1:29563229chr1:11345701ENST0000037680402160_1800180.0TransmembraneHelical
TgeneUBIAD1chr1:29563229chr1:11345701ENST0000037680402188_2080180.0TransmembraneHelical
TgeneUBIAD1chr1:29563229chr1:11345701ENST0000037680402209_2290180.0TransmembraneHelical
TgeneUBIAD1chr1:29563229chr1:11345701ENST0000037680402245_2670180.0TransmembraneHelical
TgeneUBIAD1chr1:29563229chr1:11345701ENST0000037680402277_2970180.0TransmembraneHelical
TgeneUBIAD1chr1:29563229chr1:11345701ENST0000037680402315_3350180.0TransmembraneHelical
TgeneUBIAD1chr1:29563229chr1:11345701ENST000003768040283_1030180.0TransmembraneHelical
TgeneUBIAD1chr1:29563229chr1:11345701ENST0000037681002188_208176.33333333333334339.0TransmembraneHelical
TgeneUBIAD1chr1:29563229chr1:11345701ENST0000037681002209_229176.33333333333334339.0TransmembraneHelical
TgeneUBIAD1chr1:29563229chr1:11345701ENST0000037681002245_267176.33333333333334339.0TransmembraneHelical
TgeneUBIAD1chr1:29563229chr1:11345701ENST0000037681002277_297176.33333333333334339.0TransmembraneHelical
TgeneUBIAD1chr1:29563229chr1:11345701ENST0000037681002315_335176.33333333333334339.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPRUchr1:29563229chr1:11345701ENST00000345512+1311176_143924.3333333333333321447.0DomainTyrosine-protein phosphatase 2
HgenePTPRUchr1:29563229chr1:11345701ENST00000345512+131190_27524.3333333333333321447.0DomainNote=Ig-like C2-type
HgenePTPRUchr1:29563229chr1:11345701ENST00000345512+13125_18824.3333333333333321447.0DomainMAM
HgenePTPRUchr1:29563229chr1:11345701ENST00000345512+131288_38324.3333333333333321447.0DomainFibronectin type-III 1
HgenePTPRUchr1:29563229chr1:11345701ENST00000345512+131386_48424.3333333333333321447.0DomainFibronectin type-III 2
HgenePTPRUchr1:29563229chr1:11345701ENST00000345512+131485_59124.3333333333333321447.0DomainFibronectin type-III 3
HgenePTPRUchr1:29563229chr1:11345701ENST00000345512+131592_67424.3333333333333321447.0DomainFibronectin type-III 4
HgenePTPRUchr1:29563229chr1:11345701ENST00000345512+131888_114424.3333333333333321447.0DomainTyrosine-protein phosphatase 1
HgenePTPRUchr1:29563229chr1:11345701ENST00000373779+1301176_143924.3333333333333321437.0DomainTyrosine-protein phosphatase 2
HgenePTPRUchr1:29563229chr1:11345701ENST00000373779+130190_27524.3333333333333321437.0DomainNote=Ig-like C2-type
HgenePTPRUchr1:29563229chr1:11345701ENST00000373779+13025_18824.3333333333333321437.0DomainMAM
HgenePTPRUchr1:29563229chr1:11345701ENST00000373779+130288_38324.3333333333333321437.0DomainFibronectin type-III 1
HgenePTPRUchr1:29563229chr1:11345701ENST00000373779+130386_48424.3333333333333321437.0DomainFibronectin type-III 2
HgenePTPRUchr1:29563229chr1:11345701ENST00000373779+130485_59124.3333333333333321437.0DomainFibronectin type-III 3
HgenePTPRUchr1:29563229chr1:11345701ENST00000373779+130592_67424.3333333333333321437.0DomainFibronectin type-III 4
HgenePTPRUchr1:29563229chr1:11345701ENST00000373779+130888_114424.3333333333333321437.0DomainTyrosine-protein phosphatase 1
HgenePTPRUchr1:29563229chr1:11345701ENST00000428026+1301176_143924.3333333333333321434.0DomainTyrosine-protein phosphatase 2
HgenePTPRUchr1:29563229chr1:11345701ENST00000428026+130190_27524.3333333333333321434.0DomainNote=Ig-like C2-type
HgenePTPRUchr1:29563229chr1:11345701ENST00000428026+13025_18824.3333333333333321434.0DomainMAM
HgenePTPRUchr1:29563229chr1:11345701ENST00000428026+130288_38324.3333333333333321434.0DomainFibronectin type-III 1
HgenePTPRUchr1:29563229chr1:11345701ENST00000428026+130386_48424.3333333333333321434.0DomainFibronectin type-III 2
HgenePTPRUchr1:29563229chr1:11345701ENST00000428026+130485_59124.3333333333333321434.0DomainFibronectin type-III 3
HgenePTPRUchr1:29563229chr1:11345701ENST00000428026+130592_67424.3333333333333321434.0DomainFibronectin type-III 4
HgenePTPRUchr1:29563229chr1:11345701ENST00000428026+130888_114424.3333333333333321434.0DomainTyrosine-protein phosphatase 1
HgenePTPRUchr1:29563229chr1:11345701ENST00000460170+1311176_143924.3333333333333321441.0DomainTyrosine-protein phosphatase 2
HgenePTPRUchr1:29563229chr1:11345701ENST00000460170+131190_27524.3333333333333321441.0DomainNote=Ig-like C2-type
HgenePTPRUchr1:29563229chr1:11345701ENST00000460170+13125_18824.3333333333333321441.0DomainMAM
HgenePTPRUchr1:29563229chr1:11345701ENST00000460170+131288_38324.3333333333333321441.0DomainFibronectin type-III 1
HgenePTPRUchr1:29563229chr1:11345701ENST00000460170+131386_48424.3333333333333321441.0DomainFibronectin type-III 2
HgenePTPRUchr1:29563229chr1:11345701ENST00000460170+131485_59124.3333333333333321441.0DomainFibronectin type-III 3
HgenePTPRUchr1:29563229chr1:11345701ENST00000460170+131592_67424.3333333333333321441.0DomainFibronectin type-III 4
HgenePTPRUchr1:29563229chr1:11345701ENST00000460170+131888_114424.3333333333333321441.0DomainTyrosine-protein phosphatase 1
HgenePTPRUchr1:29563229chr1:11345701ENST00000345512+1311085_109124.3333333333333321447.0RegionSubstrate binding
HgenePTPRUchr1:29563229chr1:11345701ENST00000373779+1301085_109124.3333333333333321437.0RegionSubstrate binding
HgenePTPRUchr1:29563229chr1:11345701ENST00000428026+1301085_109124.3333333333333321434.0RegionSubstrate binding
HgenePTPRUchr1:29563229chr1:11345701ENST00000460170+1311085_109124.3333333333333321441.0RegionSubstrate binding
HgenePTPRUchr1:29563229chr1:11345701ENST00000345512+13119_74924.3333333333333321447.0Topological domainExtracellular
HgenePTPRUchr1:29563229chr1:11345701ENST00000345512+131771_144624.3333333333333321447.0Topological domainCytoplasmic
HgenePTPRUchr1:29563229chr1:11345701ENST00000373779+13019_74924.3333333333333321437.0Topological domainExtracellular
HgenePTPRUchr1:29563229chr1:11345701ENST00000373779+130771_144624.3333333333333321437.0Topological domainCytoplasmic
HgenePTPRUchr1:29563229chr1:11345701ENST00000428026+13019_74924.3333333333333321434.0Topological domainExtracellular
HgenePTPRUchr1:29563229chr1:11345701ENST00000428026+130771_144624.3333333333333321434.0Topological domainCytoplasmic
HgenePTPRUchr1:29563229chr1:11345701ENST00000460170+13119_74924.3333333333333321441.0Topological domainExtracellular
HgenePTPRUchr1:29563229chr1:11345701ENST00000460170+131771_144624.3333333333333321441.0Topological domainCytoplasmic
HgenePTPRUchr1:29563229chr1:11345701ENST00000345512+131750_77024.3333333333333321447.0TransmembraneHelical
HgenePTPRUchr1:29563229chr1:11345701ENST00000373779+130750_77024.3333333333333321437.0TransmembraneHelical
HgenePTPRUchr1:29563229chr1:11345701ENST00000428026+130750_77024.3333333333333321434.0TransmembraneHelical
HgenePTPRUchr1:29563229chr1:11345701ENST00000460170+131750_77024.3333333333333321441.0TransmembraneHelical
TgeneUBIAD1chr1:29563229chr1:11345701ENST0000037681002134_154176.33333333333334339.0TransmembraneHelical
TgeneUBIAD1chr1:29563229chr1:11345701ENST0000037681002160_180176.33333333333334339.0TransmembraneHelical
TgeneUBIAD1chr1:29563229chr1:11345701ENST000003768100283_103176.33333333333334339.0TransmembraneHelical


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Fusion Gene Sequence for PTPRU-UBIAD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000345512_ENST00000376810_TCGA-32-5222-01A_PTPRU_chr1_29563229_+_UBIAD1_chr1_11345701_length(transcript)=2993nt_BP=202nt
GGCGCCAGTCCCGCTCCGCGCCGCGCCGCTCCGCTCCGGCTCGGGCTCCGGCTCGCCTCGGGCTGGGCTCGGGCTCCGGGGGCGGCGTCC
CCCGCGCCGGGCCCCGGGACGGGCGGCGACGCTCCAACCATGGCCCGTGCCCAGGCGCTCGTGCTGGCACTCACCTTCCAGCTCTGCGCG
CCGGAGACCGAGACTCCGGCAGGAATTGGATTCAAGTACGTGGCTCTGGGAGACCTCATCATCCTCATCACTTTTGGCCCGCTGGCTGTG
ATGTTCGCCTACGCCATCCAGGTGGGGTCCCTGGCCATCTTCCCACTGGTCTATGCCATCCCCCTCGCCCTCAGCACCGAGGCCATTCTC
CATTCCAACAACACCAGGGACATGGAGTCCGACCGGGAGGCTGGTATCGTCACGCTGGCCATCCTCATCGGCCCCACGTTCTCCTACATT
CTCTACAACACACTGCTCTTCCTGCCCTACCTGGTCTTCAGCATCCTGGCCACACACTGCACCATCAGCCTGGCACTCCCCCTGCTTACC
ATTCCCATGGCCTTCTCCCTTGAGAGACAGTTTCGAAGCCAGGCCTTCAACAAACTGCCCCAGAGGACTGCCAAGCTCAACCTCCTGCTG
GGACTTTTCTATGTCTTTGGCATCATTCTGGCACCAGCAGGCAGTCTGCCCAAAATTTAAGGGGACAAGTAGCTCCCCCCACGACATGTC
TCCCTTTCTTAGAATATATTAAAGTCAGAGTCTCTGAGGAAGGAATGTGATTTGGCAGTCAGGGTACTAAGCATGGGTGGGAACTCCTGC
CTTATAAAAATTGTTTTTGTGTTCTTAAAGATAATATGTTGTTTTTCTGTTTTTTGTTTTTTCCATTTTATGGGGAATTTAAAAACCATT
CTTGTATCAGAAGGTGAATTAGGCGCATGGTCTTTGTTTTATTAATAATTTCCACTAGAGGGTGTTCTCAGGTCACTTTGCAGTGAAGTG
GACTTAGTTCCTCCTTGTTCTGTACAAAATGTCTCCAGACTTTGTAAAGGAGCTGCCCAGTTTGGCCTCCTGTCCCGAAAAGACCCTAAT
AACTAGGCAGAGTGTTGTCCTGCTTTCTTCGTCTCGTAGGATGTGCTATGATTGGTGCCAGGCCTCACTAACACAGGGGCTACCTGTCTC
TTATTCTCAGCACCTGTGTCCTGAGATACGCTGCCTGAGACAGAGAGAGTCCCTCATTAACAGCCTGTGTGGCTGTCAGCTTTTTGCCTA
AATTGTGATTCAGATGCTTTTGTTCTCTCTCCTTTCACTTATTGCCACAGTTGAGGAAAAGTGTCAGATTACCCTGCAGCAAGACAAGCC
AAGGACTGGGAGGGAAAAAAAAACCACTCTGGAGGCAACTGAGAAAATCACTGCTTTTGGATAGGAATCAGTAGGGTGGCTGTTTTCCCT
TTGTTGAATCTACTAGAGTGACAGGAAGGACTCCCAGCCCTTTCAGTAACTATCAGGAGCCCTGAAACGGTAGAGGCACTGCCATCCTTG
TGGGATACTCAAAGCCCACAGGGCTTTTCCCTCCCTATTGCATCTTCTGATGCTCCCCACACCTACCCTCCACCTCTCCACCTCTGTGGT
GTTCCCATTTGTGTGTTTCCCATCTGTGGAGCCAGACTGAGCAATAGCTTAGCAGCGAGTCAGGGACAGCTGCCACTTTCCACAGAGCCA
CAGGATGGGCAGAGCAGGGACCCAGGGAATGAATAGCCAGTGGACAAACAGTCTTGAGCTCTGTTCAGCCAGAGTGATGGGCCCTGCCAG
TTAAGGGGCTGTGTCTTCATCCTTGAAGACAGATGTGCAATATTGACCCTGCCTCTCCCCAGGGCTTTGTGGAAAGATAGTTGAGGGCTT
TAGTGAGATCACACTCAGAGTGGGGCAATTCCAGCATTTATCCTGGCTGCGTTTCATTGCATTGTCTGTGAAGTATAATTTCTGGGCCAG
AATTGCTCAGTTGCATTTGATCCAGGACTATAGATTGGAAATGGGTCATCATTGTTTTCTGTTGTGATTATAGCCATTCTAGTAGGCGTT
TAAGGTCATGGCCTGCAGAAAATGATGTAAGAACTAGTTCTTAATCTTTCAGATCAAGCTAATGATGATATGGAACCTTGAGTTCGAATT
GATTGGTTTACTTGGAAAAAAACATGTTTGAAAATTGCAAAAGTTCCGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGA
GGCCGAGACGGGCGGATCACGAGGTCAGGAGATCGAGACCATCTTGGCTAACACGGTGAAACCCCGTTTCTACTAAAAATACAAAAAATT
AGCCAGGCGTGTTGGCGGGCGCCTGTAGTCCCAGCTACCTGGGCGGCTGAGGCAGGAGCATGGCGTGAACCCAGGAGGCGGAGCTTGCAG
TGAGCTGAGATCATGCCACTGCACTCCAACCTGGGGGACACAGCAAGACTCCGTCTCAAAAAAAAAAAAAGAAAAAGAAAATTGCAAAAG
TTCCTCTAAAGTTAAATCAAAGGTGGTTTGTCTAGCAGAGAGCCAGAATCTTCTAATAGTGGGCAGAGCCCAGAGACAAGGGGAAGAAAG
ATGACCTTCTCCCCAGTCCTTCCCAGCACCATTTTTGTTTCACACCAGGCTTGTGGCATTTTGGTGCTCACAGGGGTTTTGCCTTCTGAC
CTCTCCTTGGAGTAGGCCATTCTCATGCAGGGCTCACCCTGAGGCAGGAGGACCAAGGGCTCCCTGCGTCCACGGACCACGTATGCCTTG
GTGGTCACTCCCATCGGGGCTATCAGTTCTGCACTGTGCCCTGGTGCGGATTTTAATGCATATTTTTATATATAAATGTTCCCAAAGGCC
AAATTTGTTGCCAGGTTTTATACGCAGGTCACCATAATTTGTATTATGTTCCCTGAGTCAATGAAGGTTTTCTTTAGACTTCTTAATTAA

>In-frame_ENST00000345512_ENST00000376810_TCGA-32-5222-01A_PTPRU_chr1_29563229_+_UBIAD1_chr1_11345701_length(amino acids)=186AA_start in transcript=129_stop in transcript=689
MARAQALVLALTFQLCAPETETPAGIGFKYVALGDLIILITFGPLAVMFAYAIQVGSLAIFPLVYAIPLALSTEAILHSNNTRDMESDRE
AGIVTLAILIGPTFSYILYNTLLFLPYLVFSILATHCTISLALPLLTIPMAFSLERQFRSQAFNKLPQRTAKLNLLLGLFYVFGIILAPA

--------------------------------------------------------------
>In-frame_ENST00000373779_ENST00000376810_TCGA-32-5222-01A_PTPRU_chr1_29563229_+_UBIAD1_chr1_11345701_length(transcript)=2993nt_BP=202nt
GGCGCCAGTCCCGCTCCGCGCCGCGCCGCTCCGCTCCGGCTCGGGCTCCGGCTCGCCTCGGGCTGGGCTCGGGCTCCGGGGGCGGCGTCC
CCCGCGCCGGGCCCCGGGACGGGCGGCGACGCTCCAACCATGGCCCGTGCCCAGGCGCTCGTGCTGGCACTCACCTTCCAGCTCTGCGCG
CCGGAGACCGAGACTCCGGCAGGAATTGGATTCAAGTACGTGGCTCTGGGAGACCTCATCATCCTCATCACTTTTGGCCCGCTGGCTGTG
ATGTTCGCCTACGCCATCCAGGTGGGGTCCCTGGCCATCTTCCCACTGGTCTATGCCATCCCCCTCGCCCTCAGCACCGAGGCCATTCTC
CATTCCAACAACACCAGGGACATGGAGTCCGACCGGGAGGCTGGTATCGTCACGCTGGCCATCCTCATCGGCCCCACGTTCTCCTACATT
CTCTACAACACACTGCTCTTCCTGCCCTACCTGGTCTTCAGCATCCTGGCCACACACTGCACCATCAGCCTGGCACTCCCCCTGCTTACC
ATTCCCATGGCCTTCTCCCTTGAGAGACAGTTTCGAAGCCAGGCCTTCAACAAACTGCCCCAGAGGACTGCCAAGCTCAACCTCCTGCTG
GGACTTTTCTATGTCTTTGGCATCATTCTGGCACCAGCAGGCAGTCTGCCCAAAATTTAAGGGGACAAGTAGCTCCCCCCACGACATGTC
TCCCTTTCTTAGAATATATTAAAGTCAGAGTCTCTGAGGAAGGAATGTGATTTGGCAGTCAGGGTACTAAGCATGGGTGGGAACTCCTGC
CTTATAAAAATTGTTTTTGTGTTCTTAAAGATAATATGTTGTTTTTCTGTTTTTTGTTTTTTCCATTTTATGGGGAATTTAAAAACCATT
CTTGTATCAGAAGGTGAATTAGGCGCATGGTCTTTGTTTTATTAATAATTTCCACTAGAGGGTGTTCTCAGGTCACTTTGCAGTGAAGTG
GACTTAGTTCCTCCTTGTTCTGTACAAAATGTCTCCAGACTTTGTAAAGGAGCTGCCCAGTTTGGCCTCCTGTCCCGAAAAGACCCTAAT
AACTAGGCAGAGTGTTGTCCTGCTTTCTTCGTCTCGTAGGATGTGCTATGATTGGTGCCAGGCCTCACTAACACAGGGGCTACCTGTCTC
TTATTCTCAGCACCTGTGTCCTGAGATACGCTGCCTGAGACAGAGAGAGTCCCTCATTAACAGCCTGTGTGGCTGTCAGCTTTTTGCCTA
AATTGTGATTCAGATGCTTTTGTTCTCTCTCCTTTCACTTATTGCCACAGTTGAGGAAAAGTGTCAGATTACCCTGCAGCAAGACAAGCC
AAGGACTGGGAGGGAAAAAAAAACCACTCTGGAGGCAACTGAGAAAATCACTGCTTTTGGATAGGAATCAGTAGGGTGGCTGTTTTCCCT
TTGTTGAATCTACTAGAGTGACAGGAAGGACTCCCAGCCCTTTCAGTAACTATCAGGAGCCCTGAAACGGTAGAGGCACTGCCATCCTTG
TGGGATACTCAAAGCCCACAGGGCTTTTCCCTCCCTATTGCATCTTCTGATGCTCCCCACACCTACCCTCCACCTCTCCACCTCTGTGGT
GTTCCCATTTGTGTGTTTCCCATCTGTGGAGCCAGACTGAGCAATAGCTTAGCAGCGAGTCAGGGACAGCTGCCACTTTCCACAGAGCCA
CAGGATGGGCAGAGCAGGGACCCAGGGAATGAATAGCCAGTGGACAAACAGTCTTGAGCTCTGTTCAGCCAGAGTGATGGGCCCTGCCAG
TTAAGGGGCTGTGTCTTCATCCTTGAAGACAGATGTGCAATATTGACCCTGCCTCTCCCCAGGGCTTTGTGGAAAGATAGTTGAGGGCTT
TAGTGAGATCACACTCAGAGTGGGGCAATTCCAGCATTTATCCTGGCTGCGTTTCATTGCATTGTCTGTGAAGTATAATTTCTGGGCCAG
AATTGCTCAGTTGCATTTGATCCAGGACTATAGATTGGAAATGGGTCATCATTGTTTTCTGTTGTGATTATAGCCATTCTAGTAGGCGTT
TAAGGTCATGGCCTGCAGAAAATGATGTAAGAACTAGTTCTTAATCTTTCAGATCAAGCTAATGATGATATGGAACCTTGAGTTCGAATT
GATTGGTTTACTTGGAAAAAAACATGTTTGAAAATTGCAAAAGTTCCGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGA
GGCCGAGACGGGCGGATCACGAGGTCAGGAGATCGAGACCATCTTGGCTAACACGGTGAAACCCCGTTTCTACTAAAAATACAAAAAATT
AGCCAGGCGTGTTGGCGGGCGCCTGTAGTCCCAGCTACCTGGGCGGCTGAGGCAGGAGCATGGCGTGAACCCAGGAGGCGGAGCTTGCAG
TGAGCTGAGATCATGCCACTGCACTCCAACCTGGGGGACACAGCAAGACTCCGTCTCAAAAAAAAAAAAAGAAAAAGAAAATTGCAAAAG
TTCCTCTAAAGTTAAATCAAAGGTGGTTTGTCTAGCAGAGAGCCAGAATCTTCTAATAGTGGGCAGAGCCCAGAGACAAGGGGAAGAAAG
ATGACCTTCTCCCCAGTCCTTCCCAGCACCATTTTTGTTTCACACCAGGCTTGTGGCATTTTGGTGCTCACAGGGGTTTTGCCTTCTGAC
CTCTCCTTGGAGTAGGCCATTCTCATGCAGGGCTCACCCTGAGGCAGGAGGACCAAGGGCTCCCTGCGTCCACGGACCACGTATGCCTTG
GTGGTCACTCCCATCGGGGCTATCAGTTCTGCACTGTGCCCTGGTGCGGATTTTAATGCATATTTTTATATATAAATGTTCCCAAAGGCC
AAATTTGTTGCCAGGTTTTATACGCAGGTCACCATAATTTGTATTATGTTCCCTGAGTCAATGAAGGTTTTCTTTAGACTTCTTAATTAA

>In-frame_ENST00000373779_ENST00000376810_TCGA-32-5222-01A_PTPRU_chr1_29563229_+_UBIAD1_chr1_11345701_length(amino acids)=186AA_start in transcript=129_stop in transcript=689
MARAQALVLALTFQLCAPETETPAGIGFKYVALGDLIILITFGPLAVMFAYAIQVGSLAIFPLVYAIPLALSTEAILHSNNTRDMESDRE
AGIVTLAILIGPTFSYILYNTLLFLPYLVFSILATHCTISLALPLLTIPMAFSLERQFRSQAFNKLPQRTAKLNLLLGLFYVFGIILAPA

--------------------------------------------------------------
>In-frame_ENST00000356870_ENST00000376810_TCGA-32-5222-01A_PTPRU_chr1_29563229_+_UBIAD1_chr1_11345701_length(transcript)=2974nt_BP=183nt
GCCGCGCCGCTCCGCTCCGGCTCGGGCTCCGGCTCGCCTCGGGCTGGGCTCGGGCTCCGGGGGCGGCGTCCCCCGCGCCGGGCCCCGGGA
CGGGCGGCGACGCTCCAACCATGGCCCGTGCCCAGGCGCTCGTGCTGGCACTCACCTTCCAGCTCTGCGCGCCGGAGACCGAGACTCCGG
CAGGAATTGGATTCAAGTACGTGGCTCTGGGAGACCTCATCATCCTCATCACTTTTGGCCCGCTGGCTGTGATGTTCGCCTACGCCATCC
AGGTGGGGTCCCTGGCCATCTTCCCACTGGTCTATGCCATCCCCCTCGCCCTCAGCACCGAGGCCATTCTCCATTCCAACAACACCAGGG
ACATGGAGTCCGACCGGGAGGCTGGTATCGTCACGCTGGCCATCCTCATCGGCCCCACGTTCTCCTACATTCTCTACAACACACTGCTCT
TCCTGCCCTACCTGGTCTTCAGCATCCTGGCCACACACTGCACCATCAGCCTGGCACTCCCCCTGCTTACCATTCCCATGGCCTTCTCCC
TTGAGAGACAGTTTCGAAGCCAGGCCTTCAACAAACTGCCCCAGAGGACTGCCAAGCTCAACCTCCTGCTGGGACTTTTCTATGTCTTTG
GCATCATTCTGGCACCAGCAGGCAGTCTGCCCAAAATTTAAGGGGACAAGTAGCTCCCCCCACGACATGTCTCCCTTTCTTAGAATATAT
TAAAGTCAGAGTCTCTGAGGAAGGAATGTGATTTGGCAGTCAGGGTACTAAGCATGGGTGGGAACTCCTGCCTTATAAAAATTGTTTTTG
TGTTCTTAAAGATAATATGTTGTTTTTCTGTTTTTTGTTTTTTCCATTTTATGGGGAATTTAAAAACCATTCTTGTATCAGAAGGTGAAT
TAGGCGCATGGTCTTTGTTTTATTAATAATTTCCACTAGAGGGTGTTCTCAGGTCACTTTGCAGTGAAGTGGACTTAGTTCCTCCTTGTT
CTGTACAAAATGTCTCCAGACTTTGTAAAGGAGCTGCCCAGTTTGGCCTCCTGTCCCGAAAAGACCCTAATAACTAGGCAGAGTGTTGTC
CTGCTTTCTTCGTCTCGTAGGATGTGCTATGATTGGTGCCAGGCCTCACTAACACAGGGGCTACCTGTCTCTTATTCTCAGCACCTGTGT
CCTGAGATACGCTGCCTGAGACAGAGAGAGTCCCTCATTAACAGCCTGTGTGGCTGTCAGCTTTTTGCCTAAATTGTGATTCAGATGCTT
TTGTTCTCTCTCCTTTCACTTATTGCCACAGTTGAGGAAAAGTGTCAGATTACCCTGCAGCAAGACAAGCCAAGGACTGGGAGGGAAAAA
AAAACCACTCTGGAGGCAACTGAGAAAATCACTGCTTTTGGATAGGAATCAGTAGGGTGGCTGTTTTCCCTTTGTTGAATCTACTAGAGT
GACAGGAAGGACTCCCAGCCCTTTCAGTAACTATCAGGAGCCCTGAAACGGTAGAGGCACTGCCATCCTTGTGGGATACTCAAAGCCCAC
AGGGCTTTTCCCTCCCTATTGCATCTTCTGATGCTCCCCACACCTACCCTCCACCTCTCCACCTCTGTGGTGTTCCCATTTGTGTGTTTC
CCATCTGTGGAGCCAGACTGAGCAATAGCTTAGCAGCGAGTCAGGGACAGCTGCCACTTTCCACAGAGCCACAGGATGGGCAGAGCAGGG
ACCCAGGGAATGAATAGCCAGTGGACAAACAGTCTTGAGCTCTGTTCAGCCAGAGTGATGGGCCCTGCCAGTTAAGGGGCTGTGTCTTCA
TCCTTGAAGACAGATGTGCAATATTGACCCTGCCTCTCCCCAGGGCTTTGTGGAAAGATAGTTGAGGGCTTTAGTGAGATCACACTCAGA
GTGGGGCAATTCCAGCATTTATCCTGGCTGCGTTTCATTGCATTGTCTGTGAAGTATAATTTCTGGGCCAGAATTGCTCAGTTGCATTTG
ATCCAGGACTATAGATTGGAAATGGGTCATCATTGTTTTCTGTTGTGATTATAGCCATTCTAGTAGGCGTTTAAGGTCATGGCCTGCAGA
AAATGATGTAAGAACTAGTTCTTAATCTTTCAGATCAAGCTAATGATGATATGGAACCTTGAGTTCGAATTGATTGGTTTACTTGGAAAA
AAACATGTTTGAAAATTGCAAAAGTTCCGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGACGGGCGGATCA
CGAGGTCAGGAGATCGAGACCATCTTGGCTAACACGGTGAAACCCCGTTTCTACTAAAAATACAAAAAATTAGCCAGGCGTGTTGGCGGG
CGCCTGTAGTCCCAGCTACCTGGGCGGCTGAGGCAGGAGCATGGCGTGAACCCAGGAGGCGGAGCTTGCAGTGAGCTGAGATCATGCCAC
TGCACTCCAACCTGGGGGACACAGCAAGACTCCGTCTCAAAAAAAAAAAAAGAAAAAGAAAATTGCAAAAGTTCCTCTAAAGTTAAATCA
AAGGTGGTTTGTCTAGCAGAGAGCCAGAATCTTCTAATAGTGGGCAGAGCCCAGAGACAAGGGGAAGAAAGATGACCTTCTCCCCAGTCC
TTCCCAGCACCATTTTTGTTTCACACCAGGCTTGTGGCATTTTGGTGCTCACAGGGGTTTTGCCTTCTGACCTCTCCTTGGAGTAGGCCA
TTCTCATGCAGGGCTCACCCTGAGGCAGGAGGACCAAGGGCTCCCTGCGTCCACGGACCACGTATGCCTTGGTGGTCACTCCCATCGGGG
CTATCAGTTCTGCACTGTGCCCTGGTGCGGATTTTAATGCATATTTTTATATATAAATGTTCCCAAAGGCCAAATTTGTTGCCAGGTTTT
ATACGCAGGTCACCATAATTTGTATTATGTTCCCTGAGTCAATGAAGGTTTTCTTTAGACTTCTTAATTAAAAAGAGAAGAAAGAAAATG

>In-frame_ENST00000356870_ENST00000376810_TCGA-32-5222-01A_PTPRU_chr1_29563229_+_UBIAD1_chr1_11345701_length(amino acids)=186AA_start in transcript=110_stop in transcript=670
MARAQALVLALTFQLCAPETETPAGIGFKYVALGDLIILITFGPLAVMFAYAIQVGSLAIFPLVYAIPLALSTEAILHSNNTRDMESDRE
AGIVTLAILIGPTFSYILYNTLLFLPYLVFSILATHCTISLALPLLTIPMAFSLERQFRSQAFNKLPQRTAKLNLLLGLFYVFGIILAPA

--------------------------------------------------------------
>In-frame_ENST00000323874_ENST00000376810_TCGA-32-5222-01A_PTPRU_chr1_29563229_+_UBIAD1_chr1_11345701_length(transcript)=2974nt_BP=183nt
GCCGCGCCGCTCCGCTCCGGCTCGGGCTCCGGCTCGCCTCGGGCTGGGCTCGGGCTCCGGGGGCGGCGTCCCCCGCGCCGGGCCCCGGGA
CGGGCGGCGACGCTCCAACCATGGCCCGTGCCCAGGCGCTCGTGCTGGCACTCACCTTCCAGCTCTGCGCGCCGGAGACCGAGACTCCGG
CAGGAATTGGATTCAAGTACGTGGCTCTGGGAGACCTCATCATCCTCATCACTTTTGGCCCGCTGGCTGTGATGTTCGCCTACGCCATCC
AGGTGGGGTCCCTGGCCATCTTCCCACTGGTCTATGCCATCCCCCTCGCCCTCAGCACCGAGGCCATTCTCCATTCCAACAACACCAGGG
ACATGGAGTCCGACCGGGAGGCTGGTATCGTCACGCTGGCCATCCTCATCGGCCCCACGTTCTCCTACATTCTCTACAACACACTGCTCT
TCCTGCCCTACCTGGTCTTCAGCATCCTGGCCACACACTGCACCATCAGCCTGGCACTCCCCCTGCTTACCATTCCCATGGCCTTCTCCC
TTGAGAGACAGTTTCGAAGCCAGGCCTTCAACAAACTGCCCCAGAGGACTGCCAAGCTCAACCTCCTGCTGGGACTTTTCTATGTCTTTG
GCATCATTCTGGCACCAGCAGGCAGTCTGCCCAAAATTTAAGGGGACAAGTAGCTCCCCCCACGACATGTCTCCCTTTCTTAGAATATAT
TAAAGTCAGAGTCTCTGAGGAAGGAATGTGATTTGGCAGTCAGGGTACTAAGCATGGGTGGGAACTCCTGCCTTATAAAAATTGTTTTTG
TGTTCTTAAAGATAATATGTTGTTTTTCTGTTTTTTGTTTTTTCCATTTTATGGGGAATTTAAAAACCATTCTTGTATCAGAAGGTGAAT
TAGGCGCATGGTCTTTGTTTTATTAATAATTTCCACTAGAGGGTGTTCTCAGGTCACTTTGCAGTGAAGTGGACTTAGTTCCTCCTTGTT
CTGTACAAAATGTCTCCAGACTTTGTAAAGGAGCTGCCCAGTTTGGCCTCCTGTCCCGAAAAGACCCTAATAACTAGGCAGAGTGTTGTC
CTGCTTTCTTCGTCTCGTAGGATGTGCTATGATTGGTGCCAGGCCTCACTAACACAGGGGCTACCTGTCTCTTATTCTCAGCACCTGTGT
CCTGAGATACGCTGCCTGAGACAGAGAGAGTCCCTCATTAACAGCCTGTGTGGCTGTCAGCTTTTTGCCTAAATTGTGATTCAGATGCTT
TTGTTCTCTCTCCTTTCACTTATTGCCACAGTTGAGGAAAAGTGTCAGATTACCCTGCAGCAAGACAAGCCAAGGACTGGGAGGGAAAAA
AAAACCACTCTGGAGGCAACTGAGAAAATCACTGCTTTTGGATAGGAATCAGTAGGGTGGCTGTTTTCCCTTTGTTGAATCTACTAGAGT
GACAGGAAGGACTCCCAGCCCTTTCAGTAACTATCAGGAGCCCTGAAACGGTAGAGGCACTGCCATCCTTGTGGGATACTCAAAGCCCAC
AGGGCTTTTCCCTCCCTATTGCATCTTCTGATGCTCCCCACACCTACCCTCCACCTCTCCACCTCTGTGGTGTTCCCATTTGTGTGTTTC
CCATCTGTGGAGCCAGACTGAGCAATAGCTTAGCAGCGAGTCAGGGACAGCTGCCACTTTCCACAGAGCCACAGGATGGGCAGAGCAGGG
ACCCAGGGAATGAATAGCCAGTGGACAAACAGTCTTGAGCTCTGTTCAGCCAGAGTGATGGGCCCTGCCAGTTAAGGGGCTGTGTCTTCA
TCCTTGAAGACAGATGTGCAATATTGACCCTGCCTCTCCCCAGGGCTTTGTGGAAAGATAGTTGAGGGCTTTAGTGAGATCACACTCAGA
GTGGGGCAATTCCAGCATTTATCCTGGCTGCGTTTCATTGCATTGTCTGTGAAGTATAATTTCTGGGCCAGAATTGCTCAGTTGCATTTG
ATCCAGGACTATAGATTGGAAATGGGTCATCATTGTTTTCTGTTGTGATTATAGCCATTCTAGTAGGCGTTTAAGGTCATGGCCTGCAGA
AAATGATGTAAGAACTAGTTCTTAATCTTTCAGATCAAGCTAATGATGATATGGAACCTTGAGTTCGAATTGATTGGTTTACTTGGAAAA
AAACATGTTTGAAAATTGCAAAAGTTCCGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGACGGGCGGATCA
CGAGGTCAGGAGATCGAGACCATCTTGGCTAACACGGTGAAACCCCGTTTCTACTAAAAATACAAAAAATTAGCCAGGCGTGTTGGCGGG
CGCCTGTAGTCCCAGCTACCTGGGCGGCTGAGGCAGGAGCATGGCGTGAACCCAGGAGGCGGAGCTTGCAGTGAGCTGAGATCATGCCAC
TGCACTCCAACCTGGGGGACACAGCAAGACTCCGTCTCAAAAAAAAAAAAAGAAAAAGAAAATTGCAAAAGTTCCTCTAAAGTTAAATCA
AAGGTGGTTTGTCTAGCAGAGAGCCAGAATCTTCTAATAGTGGGCAGAGCCCAGAGACAAGGGGAAGAAAGATGACCTTCTCCCCAGTCC
TTCCCAGCACCATTTTTGTTTCACACCAGGCTTGTGGCATTTTGGTGCTCACAGGGGTTTTGCCTTCTGACCTCTCCTTGGAGTAGGCCA
TTCTCATGCAGGGCTCACCCTGAGGCAGGAGGACCAAGGGCTCCCTGCGTCCACGGACCACGTATGCCTTGGTGGTCACTCCCATCGGGG
CTATCAGTTCTGCACTGTGCCCTGGTGCGGATTTTAATGCATATTTTTATATATAAATGTTCCCAAAGGCCAAATTTGTTGCCAGGTTTT
ATACGCAGGTCACCATAATTTGTATTATGTTCCCTGAGTCAATGAAGGTTTTCTTTAGACTTCTTAATTAAAAAGAGAAGAAAGAAAATG

>In-frame_ENST00000323874_ENST00000376810_TCGA-32-5222-01A_PTPRU_chr1_29563229_+_UBIAD1_chr1_11345701_length(amino acids)=186AA_start in transcript=110_stop in transcript=670
MARAQALVLALTFQLCAPETETPAGIGFKYVALGDLIILITFGPLAVMFAYAIQVGSLAIFPLVYAIPLALSTEAILHSNNTRDMESDRE
AGIVTLAILIGPTFSYILYNTLLFLPYLVFSILATHCTISLALPLLTIPMAFSLERQFRSQAFNKLPQRTAKLNLLLGLFYVFGIILAPA

--------------------------------------------------------------
>In-frame_ENST00000428026_ENST00000376810_TCGA-32-5222-01A_PTPRU_chr1_29563229_+_UBIAD1_chr1_11345701_length(transcript)=2960nt_BP=169nt
CTCCGGCTCGGGCTCCGGCTCGCCTCGGGCTGGGCTCGGGCTCCGGGGGCGGCGTCCCCCGCGCCGGGCCCCGGGACGGGCGGCGACGCT
CCAACCATGGCCCGTGCCCAGGCGCTCGTGCTGGCACTCACCTTCCAGCTCTGCGCGCCGGAGACCGAGACTCCGGCAGGAATTGGATTC
AAGTACGTGGCTCTGGGAGACCTCATCATCCTCATCACTTTTGGCCCGCTGGCTGTGATGTTCGCCTACGCCATCCAGGTGGGGTCCCTG
GCCATCTTCCCACTGGTCTATGCCATCCCCCTCGCCCTCAGCACCGAGGCCATTCTCCATTCCAACAACACCAGGGACATGGAGTCCGAC
CGGGAGGCTGGTATCGTCACGCTGGCCATCCTCATCGGCCCCACGTTCTCCTACATTCTCTACAACACACTGCTCTTCCTGCCCTACCTG
GTCTTCAGCATCCTGGCCACACACTGCACCATCAGCCTGGCACTCCCCCTGCTTACCATTCCCATGGCCTTCTCCCTTGAGAGACAGTTT
CGAAGCCAGGCCTTCAACAAACTGCCCCAGAGGACTGCCAAGCTCAACCTCCTGCTGGGACTTTTCTATGTCTTTGGCATCATTCTGGCA
CCAGCAGGCAGTCTGCCCAAAATTTAAGGGGACAAGTAGCTCCCCCCACGACATGTCTCCCTTTCTTAGAATATATTAAAGTCAGAGTCT
CTGAGGAAGGAATGTGATTTGGCAGTCAGGGTACTAAGCATGGGTGGGAACTCCTGCCTTATAAAAATTGTTTTTGTGTTCTTAAAGATA
ATATGTTGTTTTTCTGTTTTTTGTTTTTTCCATTTTATGGGGAATTTAAAAACCATTCTTGTATCAGAAGGTGAATTAGGCGCATGGTCT
TTGTTTTATTAATAATTTCCACTAGAGGGTGTTCTCAGGTCACTTTGCAGTGAAGTGGACTTAGTTCCTCCTTGTTCTGTACAAAATGTC
TCCAGACTTTGTAAAGGAGCTGCCCAGTTTGGCCTCCTGTCCCGAAAAGACCCTAATAACTAGGCAGAGTGTTGTCCTGCTTTCTTCGTC
TCGTAGGATGTGCTATGATTGGTGCCAGGCCTCACTAACACAGGGGCTACCTGTCTCTTATTCTCAGCACCTGTGTCCTGAGATACGCTG
CCTGAGACAGAGAGAGTCCCTCATTAACAGCCTGTGTGGCTGTCAGCTTTTTGCCTAAATTGTGATTCAGATGCTTTTGTTCTCTCTCCT
TTCACTTATTGCCACAGTTGAGGAAAAGTGTCAGATTACCCTGCAGCAAGACAAGCCAAGGACTGGGAGGGAAAAAAAAACCACTCTGGA
GGCAACTGAGAAAATCACTGCTTTTGGATAGGAATCAGTAGGGTGGCTGTTTTCCCTTTGTTGAATCTACTAGAGTGACAGGAAGGACTC
CCAGCCCTTTCAGTAACTATCAGGAGCCCTGAAACGGTAGAGGCACTGCCATCCTTGTGGGATACTCAAAGCCCACAGGGCTTTTCCCTC
CCTATTGCATCTTCTGATGCTCCCCACACCTACCCTCCACCTCTCCACCTCTGTGGTGTTCCCATTTGTGTGTTTCCCATCTGTGGAGCC
AGACTGAGCAATAGCTTAGCAGCGAGTCAGGGACAGCTGCCACTTTCCACAGAGCCACAGGATGGGCAGAGCAGGGACCCAGGGAATGAA
TAGCCAGTGGACAAACAGTCTTGAGCTCTGTTCAGCCAGAGTGATGGGCCCTGCCAGTTAAGGGGCTGTGTCTTCATCCTTGAAGACAGA
TGTGCAATATTGACCCTGCCTCTCCCCAGGGCTTTGTGGAAAGATAGTTGAGGGCTTTAGTGAGATCACACTCAGAGTGGGGCAATTCCA
GCATTTATCCTGGCTGCGTTTCATTGCATTGTCTGTGAAGTATAATTTCTGGGCCAGAATTGCTCAGTTGCATTTGATCCAGGACTATAG
ATTGGAAATGGGTCATCATTGTTTTCTGTTGTGATTATAGCCATTCTAGTAGGCGTTTAAGGTCATGGCCTGCAGAAAATGATGTAAGAA
CTAGTTCTTAATCTTTCAGATCAAGCTAATGATGATATGGAACCTTGAGTTCGAATTGATTGGTTTACTTGGAAAAAAACATGTTTGAAA
ATTGCAAAAGTTCCGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGACGGGCGGATCACGAGGTCAGGAGAT
CGAGACCATCTTGGCTAACACGGTGAAACCCCGTTTCTACTAAAAATACAAAAAATTAGCCAGGCGTGTTGGCGGGCGCCTGTAGTCCCA
GCTACCTGGGCGGCTGAGGCAGGAGCATGGCGTGAACCCAGGAGGCGGAGCTTGCAGTGAGCTGAGATCATGCCACTGCACTCCAACCTG
GGGGACACAGCAAGACTCCGTCTCAAAAAAAAAAAAAGAAAAAGAAAATTGCAAAAGTTCCTCTAAAGTTAAATCAAAGGTGGTTTGTCT
AGCAGAGAGCCAGAATCTTCTAATAGTGGGCAGAGCCCAGAGACAAGGGGAAGAAAGATGACCTTCTCCCCAGTCCTTCCCAGCACCATT
TTTGTTTCACACCAGGCTTGTGGCATTTTGGTGCTCACAGGGGTTTTGCCTTCTGACCTCTCCTTGGAGTAGGCCATTCTCATGCAGGGC
TCACCCTGAGGCAGGAGGACCAAGGGCTCCCTGCGTCCACGGACCACGTATGCCTTGGTGGTCACTCCCATCGGGGCTATCAGTTCTGCA
CTGTGCCCTGGTGCGGATTTTAATGCATATTTTTATATATAAATGTTCCCAAAGGCCAAATTTGTTGCCAGGTTTTATACGCAGGTCACC

>In-frame_ENST00000428026_ENST00000376810_TCGA-32-5222-01A_PTPRU_chr1_29563229_+_UBIAD1_chr1_11345701_length(amino acids)=186AA_start in transcript=96_stop in transcript=656
MARAQALVLALTFQLCAPETETPAGIGFKYVALGDLIILITFGPLAVMFAYAIQVGSLAIFPLVYAIPLALSTEAILHSNNTRDMESDRE
AGIVTLAILIGPTFSYILYNTLLFLPYLVFSILATHCTISLALPLLTIPMAFSLERQFRSQAFNKLPQRTAKLNLLLGLFYVFGIILAPA

--------------------------------------------------------------
>In-frame_ENST00000460170_ENST00000376810_TCGA-32-5222-01A_PTPRU_chr1_29563229_+_UBIAD1_chr1_11345701_length(transcript)=2870nt_BP=79nt
CCAACCATGGCCCGTGCCCAGGCGCTCGTGCTGGCACTCACCTTCCAGCTCTGCGCGCCGGAGACCGAGACTCCGGCAGGAATTGGATTC
AAGTACGTGGCTCTGGGAGACCTCATCATCCTCATCACTTTTGGCCCGCTGGCTGTGATGTTCGCCTACGCCATCCAGGTGGGGTCCCTG
GCCATCTTCCCACTGGTCTATGCCATCCCCCTCGCCCTCAGCACCGAGGCCATTCTCCATTCCAACAACACCAGGGACATGGAGTCCGAC
CGGGAGGCTGGTATCGTCACGCTGGCCATCCTCATCGGCCCCACGTTCTCCTACATTCTCTACAACACACTGCTCTTCCTGCCCTACCTG
GTCTTCAGCATCCTGGCCACACACTGCACCATCAGCCTGGCACTCCCCCTGCTTACCATTCCCATGGCCTTCTCCCTTGAGAGACAGTTT
CGAAGCCAGGCCTTCAACAAACTGCCCCAGAGGACTGCCAAGCTCAACCTCCTGCTGGGACTTTTCTATGTCTTTGGCATCATTCTGGCA
CCAGCAGGCAGTCTGCCCAAAATTTAAGGGGACAAGTAGCTCCCCCCACGACATGTCTCCCTTTCTTAGAATATATTAAAGTCAGAGTCT
CTGAGGAAGGAATGTGATTTGGCAGTCAGGGTACTAAGCATGGGTGGGAACTCCTGCCTTATAAAAATTGTTTTTGTGTTCTTAAAGATA
ATATGTTGTTTTTCTGTTTTTTGTTTTTTCCATTTTATGGGGAATTTAAAAACCATTCTTGTATCAGAAGGTGAATTAGGCGCATGGTCT
TTGTTTTATTAATAATTTCCACTAGAGGGTGTTCTCAGGTCACTTTGCAGTGAAGTGGACTTAGTTCCTCCTTGTTCTGTACAAAATGTC
TCCAGACTTTGTAAAGGAGCTGCCCAGTTTGGCCTCCTGTCCCGAAAAGACCCTAATAACTAGGCAGAGTGTTGTCCTGCTTTCTTCGTC
TCGTAGGATGTGCTATGATTGGTGCCAGGCCTCACTAACACAGGGGCTACCTGTCTCTTATTCTCAGCACCTGTGTCCTGAGATACGCTG
CCTGAGACAGAGAGAGTCCCTCATTAACAGCCTGTGTGGCTGTCAGCTTTTTGCCTAAATTGTGATTCAGATGCTTTTGTTCTCTCTCCT
TTCACTTATTGCCACAGTTGAGGAAAAGTGTCAGATTACCCTGCAGCAAGACAAGCCAAGGACTGGGAGGGAAAAAAAAACCACTCTGGA
GGCAACTGAGAAAATCACTGCTTTTGGATAGGAATCAGTAGGGTGGCTGTTTTCCCTTTGTTGAATCTACTAGAGTGACAGGAAGGACTC
CCAGCCCTTTCAGTAACTATCAGGAGCCCTGAAACGGTAGAGGCACTGCCATCCTTGTGGGATACTCAAAGCCCACAGGGCTTTTCCCTC
CCTATTGCATCTTCTGATGCTCCCCACACCTACCCTCCACCTCTCCACCTCTGTGGTGTTCCCATTTGTGTGTTTCCCATCTGTGGAGCC
AGACTGAGCAATAGCTTAGCAGCGAGTCAGGGACAGCTGCCACTTTCCACAGAGCCACAGGATGGGCAGAGCAGGGACCCAGGGAATGAA
TAGCCAGTGGACAAACAGTCTTGAGCTCTGTTCAGCCAGAGTGATGGGCCCTGCCAGTTAAGGGGCTGTGTCTTCATCCTTGAAGACAGA
TGTGCAATATTGACCCTGCCTCTCCCCAGGGCTTTGTGGAAAGATAGTTGAGGGCTTTAGTGAGATCACACTCAGAGTGGGGCAATTCCA
GCATTTATCCTGGCTGCGTTTCATTGCATTGTCTGTGAAGTATAATTTCTGGGCCAGAATTGCTCAGTTGCATTTGATCCAGGACTATAG
ATTGGAAATGGGTCATCATTGTTTTCTGTTGTGATTATAGCCATTCTAGTAGGCGTTTAAGGTCATGGCCTGCAGAAAATGATGTAAGAA
CTAGTTCTTAATCTTTCAGATCAAGCTAATGATGATATGGAACCTTGAGTTCGAATTGATTGGTTTACTTGGAAAAAAACATGTTTGAAA
ATTGCAAAAGTTCCGCCGGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGACGGGCGGATCACGAGGTCAGGAGAT
CGAGACCATCTTGGCTAACACGGTGAAACCCCGTTTCTACTAAAAATACAAAAAATTAGCCAGGCGTGTTGGCGGGCGCCTGTAGTCCCA
GCTACCTGGGCGGCTGAGGCAGGAGCATGGCGTGAACCCAGGAGGCGGAGCTTGCAGTGAGCTGAGATCATGCCACTGCACTCCAACCTG
GGGGACACAGCAAGACTCCGTCTCAAAAAAAAAAAAAGAAAAAGAAAATTGCAAAAGTTCCTCTAAAGTTAAATCAAAGGTGGTTTGTCT
AGCAGAGAGCCAGAATCTTCTAATAGTGGGCAGAGCCCAGAGACAAGGGGAAGAAAGATGACCTTCTCCCCAGTCCTTCCCAGCACCATT
TTTGTTTCACACCAGGCTTGTGGCATTTTGGTGCTCACAGGGGTTTTGCCTTCTGACCTCTCCTTGGAGTAGGCCATTCTCATGCAGGGC
TCACCCTGAGGCAGGAGGACCAAGGGCTCCCTGCGTCCACGGACCACGTATGCCTTGGTGGTCACTCCCATCGGGGCTATCAGTTCTGCA
CTGTGCCCTGGTGCGGATTTTAATGCATATTTTTATATATAAATGTTCCCAAAGGCCAAATTTGTTGCCAGGTTTTATACGCAGGTCACC

>In-frame_ENST00000460170_ENST00000376810_TCGA-32-5222-01A_PTPRU_chr1_29563229_+_UBIAD1_chr1_11345701_length(amino acids)=186AA_start in transcript=6_stop in transcript=566
MARAQALVLALTFQLCAPETETPAGIGFKYVALGDLIILITFGPLAVMFAYAIQVGSLAIFPLVYAIPLALSTEAILHSNNTRDMESDRE
AGIVTLAILIGPTFSYILYNTLLFLPYLVFSILATHCTISLALPLLTIPMAFSLERQFRSQAFNKLPQRTAKLNLLLGLFYVFGIILAPA

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Fusion Gene PPI Analysis for PTPRU-UBIAD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PTPRU-UBIAD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTPRU-UBIAD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneUBIAD1C0271287Schnyder crystalline corneal dystrophy10CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneUBIAD1C0013608Edema, Cardiac1CTD_human
TgeneUBIAD1C0151699Intracranial Hemorrhage1CTD_human
TgeneUBIAD1C0553692Brain hemorrhage1CTD_human
TgeneUBIAD1C0751893Posterior Fossa Hemorrhage1CTD_human