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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PTPRZ1-DOCK4 (FusionGDB2 ID:70141)

Fusion Gene Summary for PTPRZ1-DOCK4

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRZ1-DOCK4
Fusion gene ID: 70141
HgeneTgene
Gene symbol

PTPRZ1

DOCK4

Gene ID

5803

9732

Gene nameprotein tyrosine phosphatase receptor type Z1dedicator of cytokinesis 4
SynonymsHPTPZ|HPTPzeta|PTP-ZETA|PTP18|PTPRZ|PTPZ|R-PTP-zeta-2|RPTPB|RPTPbeta|phosphacan-
Cytomap

7q31.32

7q31.1

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase zetaprotein tyrosine phosphatase, receptor-type, Z polypeptide 1protein tyrosine phosphatase, receptor-type, zeta polypeptide 1protein-tyrosine phosphatase receptor type Z polypeptide 2receptor-type tyrosine dedicator of cytokinesis protein 4
Modification date2020031320200327
UniProtAcc.

Q8N1I0

Ensembl transtripts involved in fusion geneENST00000393386, ENST00000449182, 
ENST00000483028, 		ENST00000428084, 
ENST00000494651, ENST00000437633, 
ENST00000476846, 
Fusion gene scores* DoF score15 X 14 X 7=14707 X 8 X 7=392
# samples 1910
** MAII scorelog2(19/1470*10)=-2.95174483139278
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/392*10)=-1.97085365434048
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPRZ1 [Title/Abstract] AND DOCK4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPTPRZ1(121624171)-DOCK4(111644186), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across PTPRZ1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DOCK4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EE-A20I-06APTPRZ1chr7

121624171

+DOCK4chr7

111644186

-
ChimerDB4SKCMTCGA-EE-A20I-06APTPRZ1chr7

121624171

-DOCK4chr7

111644186

-


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Fusion Gene ORF analysis for PTPRZ1-DOCK4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000393386ENST00000428084PTPRZ1chr7

121624171

+DOCK4chr7

111644186

-
5CDS-intronENST00000393386ENST00000494651PTPRZ1chr7

121624171

+DOCK4chr7

111644186

-
5CDS-intronENST00000393386ENST00000437633PTPRZ1chr7

121624171

+DOCK4chr7

111644186

-
5CDS-5UTRENST00000393386ENST00000476846PTPRZ1chr7

121624171

+DOCK4chr7

111644186

-
In-frameENST00000449182ENST00000428084PTPRZ1chr7

121624171

+DOCK4chr7

111644186

-
5CDS-intronENST00000449182ENST00000494651PTPRZ1chr7

121624171

+DOCK4chr7

111644186

-
5CDS-intronENST00000449182ENST00000437633PTPRZ1chr7

121624171

+DOCK4chr7

111644186

-
5CDS-5UTRENST00000449182ENST00000476846PTPRZ1chr7

121624171

+DOCK4chr7

111644186

-
intron-3CDSENST00000483028ENST00000428084PTPRZ1chr7

121624171

+DOCK4chr7

111644186

-
intron-intronENST00000483028ENST00000494651PTPRZ1chr7

121624171

+DOCK4chr7

111644186

-
intron-intronENST00000483028ENST00000437633PTPRZ1chr7

121624171

+DOCK4chr7

111644186

-
intron-5UTRENST00000483028ENST00000476846PTPRZ1chr7

121624171

+DOCK4chr7

111644186

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393386PTPRZ1chr7121624171+ENST00000428084DOCK4chr7111644186-9026133919272292345
ENST00000449182PTPRZ1chr7121624171+ENST00000428084DOCK4chr7111644186-875410679169572288

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393386ENST00000428084PTPRZ1chr7121624171+DOCK4chr7111644186-0.0001077620.99989223
ENST00000449182ENST00000428084PTPRZ1chr7121624171+DOCK4chr7111644186-8.31E-050.9999169

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Fusion Genomic Features for PTPRZ1-DOCK4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PTPRZ1-DOCK4


check button Go to

FGviewer for the breakpoints of chr7:121624171-chr7:111644186

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DOCK4

Q8N1I0

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens junction between cells (PubMed:12628187). Plays a role in cell migration (PubMed:20679435). {ECO:0000269|PubMed:12628187, ECO:0000269|PubMed:16464467, ECO:0000269|PubMed:20679435}.; FUNCTION: [Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. {ECO:0000269|PubMed:16464467}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPRZ1chr7:121624171chr7:111644186ENST00000393386+83036_300309.33333333333332316.0DomainAlpha-carbonic anhydrase
TgeneDOCK4chr7:121624171chr7:111644186ENST000004280840531642_186312.3333333333333341976.0Compositional biasNote=Ser-rich
TgeneDOCK4chr7:121624171chr7:111644186ENST000004280840531875_196012.3333333333333341976.0Compositional biasNote=Pro-rich
TgeneDOCK4chr7:121624171chr7:111644186ENST000004376330521642_186312.3333333333333341967.0Compositional biasNote=Ser-rich
TgeneDOCK4chr7:121624171chr7:111644186ENST000004376330521875_196012.3333333333333341967.0Compositional biasNote=Pro-rich
TgeneDOCK4chr7:121624171chr7:111644186ENST000004280840531190_159612.3333333333333341976.0DomainDOCKER
TgeneDOCK4chr7:121624171chr7:111644186ENST00000428084053401_57412.3333333333333341976.0DomainC2 DOCK-type
TgeneDOCK4chr7:121624171chr7:111644186ENST000004376330521190_159612.3333333333333341967.0DomainDOCKER
TgeneDOCK4chr7:121624171chr7:111644186ENST00000437633052401_57412.3333333333333341967.0DomainC2 DOCK-type
TgeneDOCK4chr7:121624171chr7:111644186ENST000004280840531788_179412.3333333333333341976.0MotifSH3-binding
TgeneDOCK4chr7:121624171chr7:111644186ENST000004376330521788_179412.3333333333333341967.0MotifSH3-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPRZ1chr7:121624171chr7:111644186ENST00000393386+8301717_1992309.33333333333332316.0DomainTyrosine-protein phosphatase 1
HgenePTPRZ1chr7:121624171chr7:111644186ENST00000393386+8302023_2282309.33333333333332316.0DomainTyrosine-protein phosphatase 2
HgenePTPRZ1chr7:121624171chr7:111644186ENST00000393386+830314_413309.33333333333332316.0DomainFibronectin type-III
HgenePTPRZ1chr7:121624171chr7:111644186ENST00000393386+8301933_1939309.33333333333332316.0RegionSubstrate binding
HgenePTPRZ1chr7:121624171chr7:111644186ENST00000393386+8301663_2315309.33333333333332316.0Topological domainCytoplasmic
HgenePTPRZ1chr7:121624171chr7:111644186ENST00000393386+83025_1636309.33333333333332316.0Topological domainExtracellular
HgenePTPRZ1chr7:121624171chr7:111644186ENST00000393386+8301637_1662309.33333333333332316.0TransmembraneHelical
TgeneDOCK4chr7:121624171chr7:111644186ENST000004280840536_6712.3333333333333341976.0DomainSH3
TgeneDOCK4chr7:121624171chr7:111644186ENST000004376330526_6712.3333333333333341967.0DomainSH3


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Fusion Gene Sequence for PTPRZ1-DOCK4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000393386_ENST00000428084_TCGA-EE-A20I-06A_PTPRZ1_chr7_121624171_+_DOCK4_chr7_111644186_length(transcript)=9026nt_BP=1339nt
AGGAGCCGCGGCGCGCACAGCCGGGCTGGAGCGCGCACCCGGCACTGAGGCTTCGCTGCTCTCGGAGCGCTCAGACCGCGGCCGCCGCAG
CCGGCGAAAGAGGCAAAGTCCCGCACGCCGGAGGACATGCGCCTCGGCTAGCGGCCCCGGGCCCCACCACCGTGCGGCTTTCTCCAGATT
ATTCCTCTCTCGCTGTCTCTGACTGTCTCTCTCTGTCTCTGTCTCTGTCTCTCTCTCTCTCACACACACACACACACACACAAACACACA
TACGCACGCACGATCTCACTTCGATCTATACACTGGAGGATTAAAACAAACAAACAAAAAAAACATTTCCTTCGCTCCCCCTCCCTCTCC
ACTCTGAGAAGCAGAGGAGCCGCACGGCGAGGGGCCGCAGACCGTCTGGAAATGCGAATCCTAAAGCGTTTCCTCGCTTGCATTCAGCTC
CTCTGTGTTTGCCGCCTGGATTGGGCTAATGGATACTACAGACAACAGAGAAAACTTGTTGAAGAGATTGGCTGGTCCTATACAGGAGCA
CTGAATCAAAAAAATTGGGGAAAGAAATATCCAACATGTAATAGCCCAAAACAATCTCCTATCAATATTGATGAAGATCTTACACAAGTA
AATGTGAATCTTAAGAAACTTAAATTTCAGGGTTGGGATAAAACATCATTGGAAAACACATTCATTCATAACACTGGGAAAACAGTGGAA
ATTAATCTCACTAATGACTACCGTGTCAGCGGAGGAGTTTCAGAAATGGTGTTTAAAGCAAGCAAGATAACTTTTCACTGGGGAAAATGC
AATATGTCATCTGATGGATCAGAGCATAGTTTAGAAGGACAAAAATTTCCACTTGAGATGCAAATCTACTGCTTTGATGCGGACCGATTT
TCAAGTTTTGAGGAAGCAGTCAAAGGAAAAGGGAAGTTAAGAGCTTTATCCATTTTGTTTGAGGTTGGGACAGAAGAAAATTTGGATTTC
AAAGCGATTATTGATGGAGTCGAAAGTGTTAGTCGTTTTGGGAAGCAGGCTGCTTTAGATCCATTCATACTGTTGAACCTTCTGCCAAAC
TCAACTGACAAGTATTACATTTACAATGGCTCATTGACATCTCCTCCCTGCACAGACACAGTTGACTGGATTGTTTTTAAAGATACAGTT
AGCATCTCTGAAAGCCAGTTGGCTGTTTTTTGTGAAGTTCTTACAATGCAACAATCTGGTTATGTCATGCTGATGGACTACTTACAAAAC
AATTTTCGAGAGCAACAGTACAAGTTCTCTAGACAGGTGTTTTCCTCATACACTGGAAAGGAAGAGATTCATGAAGCAGTTATTGCCAGT
TTCCGAGGAACCGTTCCATATGGCCTGTCATTGGAAATTGGAGATACAGTTCAGATCCTGGAGAAGTGTGATGGCTGGTACAGAGGATTT
GCCTTAAAAAACCCAAATATCAAGGGTATATTTCCTTCCAGCTACGTTCACTTGAAAAATGCCTGTGTAAAGAACAAAGGACAATTTGAA
ATGGTTATTCCCACTGAAGACTCTGTTATCACAGAAATGACATCAACATTAAGAGACTGGGGAACCATGTGGAAACAACTCTATGTGCGT
AATGAAGGCGATCTCTTCCACCGGCTGTGGCACATCATGAATGAAATCCTGGACCTGAGGCGGCAGGTGCTGGTGGGCCACCTCACCCAC
GACCGGATGAAGGACGTGAAGCGCCACATTACTGCCCGGCTTGACTGGGGCAATGAACAACTGGGACTGGACCTGGTGCCTAGGAAAGAG
TACGCAATGGTGGATCCGGAAGACATCAGCATTACTGAGCTCTACCGATTGATGGAACATCGACATCGGAAGAAAGACACCCCGGTGCAG
GCCAGCAGTCACCACCTCTTTGTCCAGATGAAGAGCCTCATGTGTTCCAACCTGGGAGAGGAGCTGGAGGTCATCTTCTCACTCTTTGAC
AGTAAAGAGAACCGGCCAATCAGTGAGAGATTTTTCTTGAGGCTGAATAGAAACGGGCTTCCCAAAGCCCCTGATAAACCGGAACGACAT
TGCTCCCTCTTTGTGGATTTGGGCAGCAGTGAGCTAAGAAAGGACATTTATATCACCGTGCACATTATCCGAATCGGTCGAATGGGAGCA
GGAGAAAAAAAGAATGCCTGTAGTGTCCAGTACCGACGACCCTTTGGCTGTGCAGTTCTTAGCATCGCTGACCTGCTAACAGGAGAGACA
AAGGATGACCTCATTCTGAAAGTATACATGTGTAACACAGAGAGTGAGTGGTACCAAATCCATGAGAACATCATCAAAAAGCTGAATGCA
CGTTATAACTTGACTGGCTCCAATGCAGGTTTAGCAGTTTCCTTACAGCTATTGCACGGAGACATTGAACAAATCAGAAGGGAATATTCA
TCAGTATTTTCTCATGGAGTATCCATAACAAGGAAGCTGGGATTTTCAAATATTATTATGCCTGGTGAAATGAGGAATGATTTATATATC
ACTATTGAAAGGGGAGAATTTGAGAAAGGAGGGAAGAGCGTGGCCAGAAATGTGGAAGTTACGATGTTCATTGTAGACAGTAGTGGCCAA
ACCCTGAAGGATTTTATCTCCTTCGGCTCTGGGGAGCCACCAGCCAGTGAGTACCACTCCTTTGTGCTTTACCATAACAACAGTCCCAGG
TGGTCTGAACTGCTGAAACTTCCCATTCCTGTGGATAAATTCCGGGGTGCACACATCCGCTTCGAGTTTCGGCATTGTTCCACAAAGGAG
AAAGGAGAGAAGAAGTTGTTTGGGTTTTCTTTTGTCCCTCTGATGCAAGAAGATGGTAGGACTCTTCCAGATGGCACTCATGAGCTCATC
GTGCATAAGTGTGAAGAAAACACAAATCTTCAGGATACTACCCGCTACCTCAAACTTCCCTTTTCCAAGGGCATTTTCCTTGGGAATAAT
AATCAAGCCATGAAGGCCACAAAGGAGTCCTTTTGTATTACATCTTTTCTCTGTTCCACAAAACTCACACAAAATGGTGATATGCTTGAT
CTTTTGAAATGGAGAACCCACCCAGACAAGATCACTGGCTGTCTCTCTAAATTAAAAGAAATTGATGGCTCAGAGATAGTAAAGTTTCTG
CAGGATACACTGGATACCTTATTTGGAATTTTAGATGAAAATTCCCAAAAATATGGGTCTAAAGTGTTTGATTCTTTGGTTCACATAATA
AATTTGCTGCAAGATAGCAAATTTCATCATTTTAAACCTGTAATGGACACTTACATTGAGAGTCATTTTGCTGGGGCACTTGCATACAGA
GATCTCATCAAAGTGCTCAAATGGTACGTGGACCGGATCACAGAAGCAGAGCGGCAAGAGCATATCCAGGAGGTGCTGAAGGCACAAGAA
TACATTTTTAAGTATATAGTTCAATCTCGAAGGCTGTTTTCCCTTGCCACTGGTGGGCAAAACGAAGAGGAGTTCCGCTGCTGCATTCAG
GAGCTTCTCATGTCAGTCCGTTTCTTTCTTTCGCAAGAGAGCAAAGGGTCTGGAGCATTATCTCAGTCACAGGCTGTGTTTCTGAGCTCT
TTCCCTGCCGTGTACTCAGAACTGTTGAAGCTCTTTGATGTCCGGGAAGTAGCCAACTTGGTCCAGGACACCCTGGGCAGTCTGCCGACC
ATCCTGCATGTGGATGATTCCCTGCAGGCCATCAAACTGCAGTGCATTGGCAAAACCGTGGAAAGCCAGCTTTATACCAACCCAGATTCC
CGATACATTCTTCTGCCTGTCGTGTTACATCACCTCCACATTCACTTGCAAGAACAGAAGGACCTGATCATGTGTGCACGTATCCTTAGC
AACGTATTTTGTCTTATCAAGAAAAATAGCTCAGAAAAATCTGTGCTGGAGGAAATAGATGTGATAGTGGCCAGCTTGCTGGATATTCTG
CTGAGGACCATATTGGAGATCACCAGCCGACCTCAGCCATCCAGCTCAGCAATGCGGTTCCAGTTCCAGGATGTCACTGGGGAGTTTGTT
GCTTGTCTCCTGTCCCTATTACGACAAATGACAGATAGACATTATCAACAGCTTCTTGATAGTTTTAATACAAAGGAAGAACTAAGGGAT
TTCCTGCTGCAGATATTTACTGTGTTCCGAATATTGATACGCCCGGAGATGTTTCCAAAGGACTGGACTGTTATGCGCTTGGTTGCTAAC
AATGTTATTATTACAACAGTTCTATACCTCTCAGATGCACTTCGTAAGAACTTCTTAAATGAAAACTTTGATTATAAGATCTGGGATTCC
TACTTTTACCTCGCAGTCATTTTTATAAACCAGTTGTGTCTGCAGTTGGAGATGTTCACACCTTCCAAGAAGAAAAAGGTGTTAGAAAAG
TATGGTGACATGCGGGTAACAATGGGTTGTGAAATTTTCAGCATGTGGCAAAACCTAGGAGAGCACAAGCTTCATTTTATCCCTGCCCTG
ATTGGCCCCTTCCTAGAAGTGACCTTGATACCCCAGCCAGATCTTCGGAATGTCATGATTCCAATTTTTCATGATATGATGGACTGGGAG
CAGAGGCGGAGTGGCAACTTTAAACAGGTGGAAGCCAAGCTAATTGACAAACTGGATAGCCTGATGTCAGAAGGCAAAGGTGACGAAACA
TACCGCGAGCTCTTCAACAGTATAATTCCACTATTTGGTCCCTATCCTAGTCTACTAAAGAAAATTGAGCGGGAAACATGGCGGGAAAGT
GGCGTTTCATTAATTGCTACTGTAACTCGTCTAATGGAGAGGTTGTTAGATTACAGGGACTGCATGAAAATGGGAGAGGTAGATGGCAAA
AAGATTGGCTGCACAGTTAGCCTTCTGAACTTCTATAAGACTGAACTGAACAAGGAGGAGATGTATATACGCTACATTCACAAACTCTAT
GATCTGCATCTCAAAGCACAGAACTTTACAGAAGCTGCATATACCCTCCTCTTATATGACGAGCTACTGGAATGGTCTGATCGGCCCCTC
AGGGAGTTCCTGACCTACCCCATGCAAACAGAATGGCAGCGCAAAGAGCACCTGCACCTCACCATCATCCAGAACTTTGACAGAGGCAAA
TGTTGGGAGAATGGCATTATCTTGTGCCGGAAGATTGCAGAGCAGTATGAGAGTTATTATGACTACAGAAACCTGAGCAAGATGCGGATG
ATGGAAGCCTCTTTGTATGACAAAATTATGGACCAGCAACGTCTTGAACCAGAGTTCTTCAGAGTTGGATTTTATGGAAAAAAATTTCCA
TTTTTCTTAAGAAATAAGGAGTTTGTGTGTCGAGGGCATGACTACGAGAGGCTGGAAGCCTTCCAACAGAGAATGCTGAACGAGTTCCCC
CATGCCATCGCCATGCAGCACGCCAACCAGCCCGATGAGACCATCTTCCAGGCAGAAGCTCAGTATTTGCAGATATATGCTGTGACTCCC
ATTCCAGAGAGCCAGGAGGTCCTGCAGAGAGAGGGTGTTCCGGACAACATCAAAAGCTTCTATAAAGTGAATCACATCTGGAAATTCCGC
TATGACCGACCATTTCACAAAGGCACAAAAGATAAAGAGAATGAATTCAAGAGTCTCTGGGTGGAGAGAACGTCATTATACTTGGTGCAG
AGTTTGCCTGGCATCTCTCGCTGGTTTGAAGTGGAAAAGCGTGAAGTGGTAGAAATGAGTCCTCTGGAAAATGCAATTGAAGTGCTAGAA
AATAAGAATCAGCAGCTGAAGACTCTGATTAGTCAGTGTCAGACAAGACAGATGCAGAATATTAATCCCCTGACTATGTGCCTGAATGGA
GTTATAGATGCTGCAGTTAATGGTGGCGTTTCCAGGTATCAAGAGGCATTCTTTGTCAAAGAATATATCTTAAGTCACCCTGAAGATGGG
GAGAAAATTGCACGATTAAGAGAGCTGATGCTTGAGCAGGCACAGATTCTGGAATTTGGTTTGGCCGTGCATGAGAAGTTTGTACCTCAA
GATATGAGACCCCTTCACAAAAAGCTGGTTGACCAATTCTTTGTGATGAAGTCGAGCTTAGGGATACAGGAGTTCTCTGCTTGTATGCAA
GCCAGTCCTGTCCATTTTCCTAATGGAAGCCCTCGTGTGTGTAGAAACTCAGCACCTGCTTCTGTGAGCCCAGATGGTACCAGGGTAATT
CCTAGACGCAGCCCGTTAAGTTACCCAGCTGTCAACCGATATTCTTCCTCCTCACTGTCCTCACAAGCTTCTGCTGAAGTAAGCAATATT
ACAGGGCAATCAGAAAGCTCTGATGAAGTCTTTAACATGCAGCCAAGTCCATCTACCTCAAGCTTGAGTTCTACTCACTCGGCTTCACCT
AATGTGACAAGTTCTGCTCCATCGAGTGCCAGAGCTTCTCCTTTGTTGTCTGACAAACACAAACATTCCCGAGAAAACTCTTGCCTGTCA
CCAAGAGAGAGACCATGCAGTGCCATCTATCCAACACCTGTGGAGCCTTCGCAGAGGATGCTGTTTAATCATATTGGAGACGGGGCCTTG
CCACGCAGTGACCCAAATCTCTCTGCACCTGAAAAAGCTGTGAACCCCACCCCTAGCAGCTGGAGCCTGGACAGTGGGAAGGAAGCCAAG
AACATGTCGGATAGTGGGAAACTTATCTCTCCCCCTGTCCCTCCAAGACCCACACAGACTGCTTCACCAGCAAGACACACGACATCAGTA
TCCCCCTCGCCTGCCGGGCGATCTCCATTGAAGGGCTCTGTGCAGTCTTTCACCCCCTCTCCAGTGGAGTACCACTCGCCAGGACTCATC
TCCAACTCCCCTGTCTTGTCGGGCAGCTACAGCAGTGGGATTTCTTCTCTCAGCCGGTGCAGCACGTCGGAAACCTCAGGCTTTGAAAAT
CAGGTGAATGAACAGTCGGCCCCCCTGCCGGTGCCAGTGCCGGTGCCCGTGCCGAGCTACGGCGGGGAGGAGCCAGTGCGCAAGGAGAGC
AAGACTCCGCCCCCGTACAGCGTCTACGAGCGGACTCTGCGGCGCCCCGTCCCGCTACCTCACAGCCTCTCCATCCCCGTCACGTCGGAG
CCGCCCGCGCTGCCCCCCAAGCCTCTGGCAGCGCGATCCAGCCACCTGGAGAATGGGGCCCGGAGGACTGACCCCGGCCCGCGGCCCAGG
CCCCTGCCCCGCAAGGTCTCTCAGTTATAAGTCACTTTTCTATGTACCTGCGATGCATTCTTTGCCCGTTTACAAAATAAGAAGTATGAT
GAGAAGACATTTAGTGTAGGCACTTTAATAACTTACTCAGCTCCTTCGATGAATGGAATTAAAACTTGCTTATTAAATATCATGTTGCAC
AATATTAAAAGTTGCTGATCTAAAACGCCAGATGTTAAATGAAGTATGGCTGAATTTCATTAAAACGTTTCTCATTTGGAAGTGGTAAAT
AGTGATAAAGACTCCTTTTGTACCTTTTTATGTTCACTTTTTTTTATATAGTTTAATCTTAAAACCAATACGATATTGTCAAACGATACA
ATGTGTGACAATGTTGTATCGTTTTTACTGAATACTTGATACTTGGAGAAAGCTTATTAAGTCAGTGCACATCCTAACACAGTGGTCCTT
ATTTTAGAAGACTTCTGTAAATAAGGCAAGGTTTATCAGTGCAGATCATCAGAATTAAAGTTCAAGCAGGCGAGCAAGACAGTATACTTA
AGGGGTTGCAAAGCTTGGGACTGGAAATTGTTTTGTTCTTGAAACAAAATACTTCTTTAAGGTTGCTTTTGCTGTTTGACTGCTGTCTAC
ATTCGTAAAATTCTATTTTGTGAATTGGTAGCTAAATCCCTTACTACCCTGACACCGTGGTATCTACTGTATTTCTTTTCAAGGTGCAAT
TTGCTTCAGAGTTCCAATCAGCTAGATTAAGCAAGAGGCTCCAGAAGAAATGTTTACTTGAATTTTGCGCTTCCTTTCTTGATAGTTTCC
TATATAAAATTTGTCATTGAACAAGAGCAAATGCTGAAGTATTAATGAGGCACAAATGACTGTGCCCCATTAGCAAGAATTCAGGAATCA
ATACAGACAGTATTAAATTAATAGCTTAAGTGAAGAAAAAAAAAACTTAGTGAAAATGTATTAGCACGATTAAATGGCAAAAGGACTTAT
AAAAGGCAAGGGCATTAACTTTCAGTCCTGCACAAAATAAAAAATTCCTCACGACTCTCCACTTTTACCAGTGGAGTTTGTCTTAGCTGA
CCTGTCGTCTTTCTCTTGAAGGAGGATTGCTGTAGACTTCTCTAGCTTGAATATTGCAACATAGCATCTTAGGTCTAGATAGGGATGCTA
ATGCCAGTTGTAGAAGTGTGAAAAAAGCACCTTGTATGTAGTAATGTATTTTATATCTTTGTTTTTTCTTTTACTGACTGTTTATAACAC
TCAATTGACAATAGATATGAACTGTATTTTAAATCATACTGTTAAATATTTTCCCTCTTTTGTTGGGAAGCTCATTTTAGTTTAACCATG
TTTGTTTTGTTGGTAGCTTACCTGGAAGGCAGTGACCACTTTTTTATATTCTCTTAATGAAACCATTCAGCAGGTATATGCTGTTGAGGC
TGGTTATAGAGGTTTTCTATAATAAATGTTCAAGTATTTTTGTATATAACTGGTTAATTTTAATAAGAGATACCATTATGTGTAAAAAAA
AGTAAAAATAAACGCAAACAGTTGTTGATGCAGTATGATTGTTATAATTATGCCAAATACTTTACGTATGGAAAAAGAATATTTGTACAT
ATGTGCTTTTAACAATTCTGCCATATTGACTTTACAATTTTGAATGTCGGAAAAATTAATATATGTTAAATATTTATGTTTAGTGAAAGT
GTTCATAATTGAGAAAAGGAACATATGCATTTTAGCTTTGTATCTTGCAAGTTTTGCAGTCAGAAATTTTTTGAACTAGCTTTTGCTTTT

>In-frame_ENST00000393386_ENST00000428084_TCGA-EE-A20I-06A_PTPRZ1_chr7_121624171_+_DOCK4_chr7_111644186_length(amino acids)=2345AA_start in transcript=192_stop in transcript=7229
MSLTVSLCLCLCLSLSHTHTHTHKHTYARTISLRSIHWRIKTNKQKKHFLRSPSLSTLRSRGAARRGAADRLEMRILKRFLACIQLLCVC
RLDWANGYYRQQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPKQSPINIDEDLTQVNVNLKKLKFQGWDKTSLENTFIHNTGKTVEINLT
NDYRVSGGVSEMVFKASKITFHWGKCNMSSDGSEHSLEGQKFPLEMQIYCFDADRFSSFEEAVKGKGKLRALSILFEVGTEENLDFKAII
DGVESVSRFGKQAALDPFILLNLLPNSTDKYYIYNGSLTSPPCTDTVDWIVFKDTVSISESQLAVFCEVLTMQQSGYVMLMDYLQNNFRE
QQYKFSRQVFSSYTGKEEIHEAVIASFRGTVPYGLSLEIGDTVQILEKCDGWYRGFALKNPNIKGIFPSSYVHLKNACVKNKGQFEMVIP
TEDSVITEMTSTLRDWGTMWKQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLDLVPRKEYAMV
DPEDISITELYRLMEHRHRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLRLNRNGLPKAPDKPERHCSLF
VDLGSSELRKDIYITVHIIRIGRMGAGEKKNACSVQYRRPFGCAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNL
TGSNAGLAVSLQLLHGDIEQIRREYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSVARNVEVTMFIVDSSGQTLKD
FISFGSGEPPASEYHSFVLYHNNSPRWSELLKLPIPVDKFRGAHIRFEFRHCSTKEKGEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKC
EENTNLQDTTRYLKLPFSKGIFLGNNNQAMKATKESFCITSFLCSTKLTQNGDMLDLLKWRTHPDKITGCLSKLKEIDGSEIVKFLQDTL
DTLFGILDENSQKYGSKVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGALAYRDLIKVLKWYVDRITEAERQEHIQEVLKAQEYIFK
YIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSGALSQSQAVFLSSFPAVYSELLKLFDVREVANLVQDTLGSLPTILHV
DDSLQAIKLQCIGKTVESQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSNVFCLIKKNSSEKSVLEEIDVIVASLLDILLRTI
LEITSRPQPSSSAMRFQFQDVTGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLLQIFTVFRILIRPEMFPKDWTVMRLVANNVII
TTVLYLSDALRKNFLNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYGDMRVTMGCEIFSMWQNLGEHKLHFIPALIGPF
LEVTLIPQPDLRNVMIPIFHDMMDWEQRRSGNFKQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGPYPSLLKKIERETWRESGVSL
IATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHLKAQNFTEAAYTLLLYDELLEWSDRPLREFL
TYPMQTEWQRKEHLHLTIIQNFDRGKCWENGIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLR
NKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPESQEVLQREGVPDNIKSFYKVNHIWKFRYDRP
FHKGTKDKENEFKSLWVERTSLYLVQSLPGISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDA
AVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQAQILEFGLAVHEKFVPQDMRPLHKKLVDQFFVMKSSLGIQEFSACMQASPV
HFPNGSPRVCRNSAPASVSPDGTRVIPRRSPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQPSPSTSSLSSTHSASPNVTS
SAPSSARASPLLSDKHKHSRENSCLSPRERPCSAIYPTPVEPSQRMLFNHIGDGALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSD
SGKLISPPVPPRPTQTASPARHTTSVSPSPAGRSPLKGSVQSFTPSPVEYHSPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNE
QSAPLPVPVPVPVPSYGGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPVTSEPPALPPKPLAARSSHLENGARRTDPGPRPRPLPR

--------------------------------------------------------------
>In-frame_ENST00000449182_ENST00000428084_TCGA-EE-A20I-06A_PTPRZ1_chr7_121624171_+_DOCK4_chr7_111644186_length(transcript)=8754nt_BP=1067nt
CGCACGCACGATCTCACTTCGATCTATACACTGGAGGATTAAAACAAACAAACAAAAAAAACATTTCCTTCGCTCCCCCTCCCTCTCCAC
TCTGAGAAGCAGAGGAGCCGCACGGCGAGGGGCCGCAGACCGTCTGGAAATGCGAATCCTAAAGCGTTTCCTCGCTTGCATTCAGCTCCT
CTGTGTTTGCCGCCTGGATTGGGCTAATGGATACTACAGACAACAGAGAAAACTTGTTGAAGAGATTGGCTGGTCCTATACAGGAGCACT
GAATCAAAAAAATTGGGGAAAGAAATATCCAACATGTAATAGCCCAAAACAATCTCCTATCAATATTGATGAAGATCTTACACAAGTAAA
TGTGAATCTTAAGAAACTTAAATTTCAGGGTTGGGATAAAACATCATTGGAAAACACATTCATTCATAACACTGGGAAAACAGTGGAAAT
TAATCTCACTAATGACTACCGTGTCAGCGGAGGAGTTTCAGAAATGGTGTTTAAAGCAAGCAAGATAACTTTTCACTGGGGAAAATGCAA
TATGTCATCTGATGGATCAGAGCATAGTTTAGAAGGACAAAAATTTCCACTTGAGATGCAAATCTACTGCTTTGATGCGGACCGATTTTC
AAGTTTTGAGGAAGCAGTCAAAGGAAAAGGGAAGTTAAGAGCTTTATCCATTTTGTTTGAGGTTGGGACAGAAGAAAATTTGGATTTCAA
AGCGATTATTGATGGAGTCGAAAGTGTTAGTCGTTTTGGGAAGCAGGCTGCTTTAGATCCATTCATACTGTTGAACCTTCTGCCAAACTC
AACTGACAAGTATTACATTTACAATGGCTCATTGACATCTCCTCCCTGCACAGACACAGTTGACTGGATTGTTTTTAAAGATACAGTTAG
CATCTCTGAAAGCCAGTTGGCTGTTTTTTGTGAAGTTCTTACAATGCAACAATCTGGTTATGTCATGCTGATGGACTACTTACAAAACAA
TTTTCGAGAGCAACAGTACAAGTTCTCTAGACAGGTGTTTTCCTCATACACTGGAAAGGAAGAGATTCATGAAGCAGTTATTGCCAGTTT
CCGAGGAACCGTTCCATATGGCCTGTCATTGGAAATTGGAGATACAGTTCAGATCCTGGAGAAGTGTGATGGCTGGTACAGAGGATTTGC
CTTAAAAAACCCAAATATCAAGGGTATATTTCCTTCCAGCTACGTTCACTTGAAAAATGCCTGTGTAAAGAACAAAGGACAATTTGAAAT
GGTTATTCCCACTGAAGACTCTGTTATCACAGAAATGACATCAACATTAAGAGACTGGGGAACCATGTGGAAACAACTCTATGTGCGTAA
TGAAGGCGATCTCTTCCACCGGCTGTGGCACATCATGAATGAAATCCTGGACCTGAGGCGGCAGGTGCTGGTGGGCCACCTCACCCACGA
CCGGATGAAGGACGTGAAGCGCCACATTACTGCCCGGCTTGACTGGGGCAATGAACAACTGGGACTGGACCTGGTGCCTAGGAAAGAGTA
CGCAATGGTGGATCCGGAAGACATCAGCATTACTGAGCTCTACCGATTGATGGAACATCGACATCGGAAGAAAGACACCCCGGTGCAGGC
CAGCAGTCACCACCTCTTTGTCCAGATGAAGAGCCTCATGTGTTCCAACCTGGGAGAGGAGCTGGAGGTCATCTTCTCACTCTTTGACAG
TAAAGAGAACCGGCCAATCAGTGAGAGATTTTTCTTGAGGCTGAATAGAAACGGGCTTCCCAAAGCCCCTGATAAACCGGAACGACATTG
CTCCCTCTTTGTGGATTTGGGCAGCAGTGAGCTAAGAAAGGACATTTATATCACCGTGCACATTATCCGAATCGGTCGAATGGGAGCAGG
AGAAAAAAAGAATGCCTGTAGTGTCCAGTACCGACGACCCTTTGGCTGTGCAGTTCTTAGCATCGCTGACCTGCTAACAGGAGAGACAAA
GGATGACCTCATTCTGAAAGTATACATGTGTAACACAGAGAGTGAGTGGTACCAAATCCATGAGAACATCATCAAAAAGCTGAATGCACG
TTATAACTTGACTGGCTCCAATGCAGGTTTAGCAGTTTCCTTACAGCTATTGCACGGAGACATTGAACAAATCAGAAGGGAATATTCATC
AGTATTTTCTCATGGAGTATCCATAACAAGGAAGCTGGGATTTTCAAATATTATTATGCCTGGTGAAATGAGGAATGATTTATATATCAC
TATTGAAAGGGGAGAATTTGAGAAAGGAGGGAAGAGCGTGGCCAGAAATGTGGAAGTTACGATGTTCATTGTAGACAGTAGTGGCCAAAC
CCTGAAGGATTTTATCTCCTTCGGCTCTGGGGAGCCACCAGCCAGTGAGTACCACTCCTTTGTGCTTTACCATAACAACAGTCCCAGGTG
GTCTGAACTGCTGAAACTTCCCATTCCTGTGGATAAATTCCGGGGTGCACACATCCGCTTCGAGTTTCGGCATTGTTCCACAAAGGAGAA
AGGAGAGAAGAAGTTGTTTGGGTTTTCTTTTGTCCCTCTGATGCAAGAAGATGGTAGGACTCTTCCAGATGGCACTCATGAGCTCATCGT
GCATAAGTGTGAAGAAAACACAAATCTTCAGGATACTACCCGCTACCTCAAACTTCCCTTTTCCAAGGGCATTTTCCTTGGGAATAATAA
TCAAGCCATGAAGGCCACAAAGGAGTCCTTTTGTATTACATCTTTTCTCTGTTCCACAAAACTCACACAAAATGGTGATATGCTTGATCT
TTTGAAATGGAGAACCCACCCAGACAAGATCACTGGCTGTCTCTCTAAATTAAAAGAAATTGATGGCTCAGAGATAGTAAAGTTTCTGCA
GGATACACTGGATACCTTATTTGGAATTTTAGATGAAAATTCCCAAAAATATGGGTCTAAAGTGTTTGATTCTTTGGTTCACATAATAAA
TTTGCTGCAAGATAGCAAATTTCATCATTTTAAACCTGTAATGGACACTTACATTGAGAGTCATTTTGCTGGGGCACTTGCATACAGAGA
TCTCATCAAAGTGCTCAAATGGTACGTGGACCGGATCACAGAAGCAGAGCGGCAAGAGCATATCCAGGAGGTGCTGAAGGCACAAGAATA
CATTTTTAAGTATATAGTTCAATCTCGAAGGCTGTTTTCCCTTGCCACTGGTGGGCAAAACGAAGAGGAGTTCCGCTGCTGCATTCAGGA
GCTTCTCATGTCAGTCCGTTTCTTTCTTTCGCAAGAGAGCAAAGGGTCTGGAGCATTATCTCAGTCACAGGCTGTGTTTCTGAGCTCTTT
CCCTGCCGTGTACTCAGAACTGTTGAAGCTCTTTGATGTCCGGGAAGTAGCCAACTTGGTCCAGGACACCCTGGGCAGTCTGCCGACCAT
CCTGCATGTGGATGATTCCCTGCAGGCCATCAAACTGCAGTGCATTGGCAAAACCGTGGAAAGCCAGCTTTATACCAACCCAGATTCCCG
ATACATTCTTCTGCCTGTCGTGTTACATCACCTCCACATTCACTTGCAAGAACAGAAGGACCTGATCATGTGTGCACGTATCCTTAGCAA
CGTATTTTGTCTTATCAAGAAAAATAGCTCAGAAAAATCTGTGCTGGAGGAAATAGATGTGATAGTGGCCAGCTTGCTGGATATTCTGCT
GAGGACCATATTGGAGATCACCAGCCGACCTCAGCCATCCAGCTCAGCAATGCGGTTCCAGTTCCAGGATGTCACTGGGGAGTTTGTTGC
TTGTCTCCTGTCCCTATTACGACAAATGACAGATAGACATTATCAACAGCTTCTTGATAGTTTTAATACAAAGGAAGAACTAAGGGATTT
CCTGCTGCAGATATTTACTGTGTTCCGAATATTGATACGCCCGGAGATGTTTCCAAAGGACTGGACTGTTATGCGCTTGGTTGCTAACAA
TGTTATTATTACAACAGTTCTATACCTCTCAGATGCACTTCGTAAGAACTTCTTAAATGAAAACTTTGATTATAAGATCTGGGATTCCTA
CTTTTACCTCGCAGTCATTTTTATAAACCAGTTGTGTCTGCAGTTGGAGATGTTCACACCTTCCAAGAAGAAAAAGGTGTTAGAAAAGTA
TGGTGACATGCGGGTAACAATGGGTTGTGAAATTTTCAGCATGTGGCAAAACCTAGGAGAGCACAAGCTTCATTTTATCCCTGCCCTGAT
TGGCCCCTTCCTAGAAGTGACCTTGATACCCCAGCCAGATCTTCGGAATGTCATGATTCCAATTTTTCATGATATGATGGACTGGGAGCA
GAGGCGGAGTGGCAACTTTAAACAGGTGGAAGCCAAGCTAATTGACAAACTGGATAGCCTGATGTCAGAAGGCAAAGGTGACGAAACATA
CCGCGAGCTCTTCAACAGTATAATTCCACTATTTGGTCCCTATCCTAGTCTACTAAAGAAAATTGAGCGGGAAACATGGCGGGAAAGTGG
CGTTTCATTAATTGCTACTGTAACTCGTCTAATGGAGAGGTTGTTAGATTACAGGGACTGCATGAAAATGGGAGAGGTAGATGGCAAAAA
GATTGGCTGCACAGTTAGCCTTCTGAACTTCTATAAGACTGAACTGAACAAGGAGGAGATGTATATACGCTACATTCACAAACTCTATGA
TCTGCATCTCAAAGCACAGAACTTTACAGAAGCTGCATATACCCTCCTCTTATATGACGAGCTACTGGAATGGTCTGATCGGCCCCTCAG
GGAGTTCCTGACCTACCCCATGCAAACAGAATGGCAGCGCAAAGAGCACCTGCACCTCACCATCATCCAGAACTTTGACAGAGGCAAATG
TTGGGAGAATGGCATTATCTTGTGCCGGAAGATTGCAGAGCAGTATGAGAGTTATTATGACTACAGAAACCTGAGCAAGATGCGGATGAT
GGAAGCCTCTTTGTATGACAAAATTATGGACCAGCAACGTCTTGAACCAGAGTTCTTCAGAGTTGGATTTTATGGAAAAAAATTTCCATT
TTTCTTAAGAAATAAGGAGTTTGTGTGTCGAGGGCATGACTACGAGAGGCTGGAAGCCTTCCAACAGAGAATGCTGAACGAGTTCCCCCA
TGCCATCGCCATGCAGCACGCCAACCAGCCCGATGAGACCATCTTCCAGGCAGAAGCTCAGTATTTGCAGATATATGCTGTGACTCCCAT
TCCAGAGAGCCAGGAGGTCCTGCAGAGAGAGGGTGTTCCGGACAACATCAAAAGCTTCTATAAAGTGAATCACATCTGGAAATTCCGCTA
TGACCGACCATTTCACAAAGGCACAAAAGATAAAGAGAATGAATTCAAGAGTCTCTGGGTGGAGAGAACGTCATTATACTTGGTGCAGAG
TTTGCCTGGCATCTCTCGCTGGTTTGAAGTGGAAAAGCGTGAAGTGGTAGAAATGAGTCCTCTGGAAAATGCAATTGAAGTGCTAGAAAA
TAAGAATCAGCAGCTGAAGACTCTGATTAGTCAGTGTCAGACAAGACAGATGCAGAATATTAATCCCCTGACTATGTGCCTGAATGGAGT
TATAGATGCTGCAGTTAATGGTGGCGTTTCCAGGTATCAAGAGGCATTCTTTGTCAAAGAATATATCTTAAGTCACCCTGAAGATGGGGA
GAAAATTGCACGATTAAGAGAGCTGATGCTTGAGCAGGCACAGATTCTGGAATTTGGTTTGGCCGTGCATGAGAAGTTTGTACCTCAAGA
TATGAGACCCCTTCACAAAAAGCTGGTTGACCAATTCTTTGTGATGAAGTCGAGCTTAGGGATACAGGAGTTCTCTGCTTGTATGCAAGC
CAGTCCTGTCCATTTTCCTAATGGAAGCCCTCGTGTGTGTAGAAACTCAGCACCTGCTTCTGTGAGCCCAGATGGTACCAGGGTAATTCC
TAGACGCAGCCCGTTAAGTTACCCAGCTGTCAACCGATATTCTTCCTCCTCACTGTCCTCACAAGCTTCTGCTGAAGTAAGCAATATTAC
AGGGCAATCAGAAAGCTCTGATGAAGTCTTTAACATGCAGCCAAGTCCATCTACCTCAAGCTTGAGTTCTACTCACTCGGCTTCACCTAA
TGTGACAAGTTCTGCTCCATCGAGTGCCAGAGCTTCTCCTTTGTTGTCTGACAAACACAAACATTCCCGAGAAAACTCTTGCCTGTCACC
AAGAGAGAGACCATGCAGTGCCATCTATCCAACACCTGTGGAGCCTTCGCAGAGGATGCTGTTTAATCATATTGGAGACGGGGCCTTGCC
ACGCAGTGACCCAAATCTCTCTGCACCTGAAAAAGCTGTGAACCCCACCCCTAGCAGCTGGAGCCTGGACAGTGGGAAGGAAGCCAAGAA
CATGTCGGATAGTGGGAAACTTATCTCTCCCCCTGTCCCTCCAAGACCCACACAGACTGCTTCACCAGCAAGACACACGACATCAGTATC
CCCCTCGCCTGCCGGGCGATCTCCATTGAAGGGCTCTGTGCAGTCTTTCACCCCCTCTCCAGTGGAGTACCACTCGCCAGGACTCATCTC
CAACTCCCCTGTCTTGTCGGGCAGCTACAGCAGTGGGATTTCTTCTCTCAGCCGGTGCAGCACGTCGGAAACCTCAGGCTTTGAAAATCA
GGTGAATGAACAGTCGGCCCCCCTGCCGGTGCCAGTGCCGGTGCCCGTGCCGAGCTACGGCGGGGAGGAGCCAGTGCGCAAGGAGAGCAA
GACTCCGCCCCCGTACAGCGTCTACGAGCGGACTCTGCGGCGCCCCGTCCCGCTACCTCACAGCCTCTCCATCCCCGTCACGTCGGAGCC
GCCCGCGCTGCCCCCCAAGCCTCTGGCAGCGCGATCCAGCCACCTGGAGAATGGGGCCCGGAGGACTGACCCCGGCCCGCGGCCCAGGCC
CCTGCCCCGCAAGGTCTCTCAGTTATAAGTCACTTTTCTATGTACCTGCGATGCATTCTTTGCCCGTTTACAAAATAAGAAGTATGATGA
GAAGACATTTAGTGTAGGCACTTTAATAACTTACTCAGCTCCTTCGATGAATGGAATTAAAACTTGCTTATTAAATATCATGTTGCACAA
TATTAAAAGTTGCTGATCTAAAACGCCAGATGTTAAATGAAGTATGGCTGAATTTCATTAAAACGTTTCTCATTTGGAAGTGGTAAATAG
TGATAAAGACTCCTTTTGTACCTTTTTATGTTCACTTTTTTTTATATAGTTTAATCTTAAAACCAATACGATATTGTCAAACGATACAAT
GTGTGACAATGTTGTATCGTTTTTACTGAATACTTGATACTTGGAGAAAGCTTATTAAGTCAGTGCACATCCTAACACAGTGGTCCTTAT
TTTAGAAGACTTCTGTAAATAAGGCAAGGTTTATCAGTGCAGATCATCAGAATTAAAGTTCAAGCAGGCGAGCAAGACAGTATACTTAAG
GGGTTGCAAAGCTTGGGACTGGAAATTGTTTTGTTCTTGAAACAAAATACTTCTTTAAGGTTGCTTTTGCTGTTTGACTGCTGTCTACAT
TCGTAAAATTCTATTTTGTGAATTGGTAGCTAAATCCCTTACTACCCTGACACCGTGGTATCTACTGTATTTCTTTTCAAGGTGCAATTT
GCTTCAGAGTTCCAATCAGCTAGATTAAGCAAGAGGCTCCAGAAGAAATGTTTACTTGAATTTTGCGCTTCCTTTCTTGATAGTTTCCTA
TATAAAATTTGTCATTGAACAAGAGCAAATGCTGAAGTATTAATGAGGCACAAATGACTGTGCCCCATTAGCAAGAATTCAGGAATCAAT
ACAGACAGTATTAAATTAATAGCTTAAGTGAAGAAAAAAAAAACTTAGTGAAAATGTATTAGCACGATTAAATGGCAAAAGGACTTATAA
AAGGCAAGGGCATTAACTTTCAGTCCTGCACAAAATAAAAAATTCCTCACGACTCTCCACTTTTACCAGTGGAGTTTGTCTTAGCTGACC
TGTCGTCTTTCTCTTGAAGGAGGATTGCTGTAGACTTCTCTAGCTTGAATATTGCAACATAGCATCTTAGGTCTAGATAGGGATGCTAAT
GCCAGTTGTAGAAGTGTGAAAAAAGCACCTTGTATGTAGTAATGTATTTTATATCTTTGTTTTTTCTTTTACTGACTGTTTATAACACTC
AATTGACAATAGATATGAACTGTATTTTAAATCATACTGTTAAATATTTTCCCTCTTTTGTTGGGAAGCTCATTTTAGTTTAACCATGTT
TGTTTTGTTGGTAGCTTACCTGGAAGGCAGTGACCACTTTTTTATATTCTCTTAATGAAACCATTCAGCAGGTATATGCTGTTGAGGCTG
GTTATAGAGGTTTTCTATAATAAATGTTCAAGTATTTTTGTATATAACTGGTTAATTTTAATAAGAGATACCATTATGTGTAAAAAAAAG
TAAAAATAAACGCAAACAGTTGTTGATGCAGTATGATTGTTATAATTATGCCAAATACTTTACGTATGGAAAAAGAATATTTGTACATAT
GTGCTTTTAACAATTCTGCCATATTGACTTTACAATTTTGAATGTCGGAAAAATTAATATATGTTAAATATTTATGTTTAGTGAAAGTGT
TCATAATTGAGAAAAGGAACATATGCATTTTAGCTTTGTATCTTGCAAGTTTTGCAGTCAGAAATTTTTTGAACTAGCTTTTGCTTTTGA

>In-frame_ENST00000449182_ENST00000428084_TCGA-EE-A20I-06A_PTPRZ1_chr7_121624171_+_DOCK4_chr7_111644186_length(amino acids)=2288AA_start in transcript=91_stop in transcript=6957
MRSRGAARRGAADRLEMRILKRFLACIQLLCVCRLDWANGYYRQQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPKQSPINIDEDLTQVN
VNLKKLKFQGWDKTSLENTFIHNTGKTVEINLTNDYRVSGGVSEMVFKASKITFHWGKCNMSSDGSEHSLEGQKFPLEMQIYCFDADRFS
SFEEAVKGKGKLRALSILFEVGTEENLDFKAIIDGVESVSRFGKQAALDPFILLNLLPNSTDKYYIYNGSLTSPPCTDTVDWIVFKDTVS
ISESQLAVFCEVLTMQQSGYVMLMDYLQNNFREQQYKFSRQVFSSYTGKEEIHEAVIASFRGTVPYGLSLEIGDTVQILEKCDGWYRGFA
LKNPNIKGIFPSSYVHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMWKQLYVRNEGDLFHRLWHIMNEILDLRRQVLVGHLTHD
RMKDVKRHITARLDWGNEQLGLDLVPRKEYAMVDPEDISITELYRLMEHRHRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDS
KENRPISERFFLRLNRNGLPKAPDKPERHCSLFVDLGSSELRKDIYITVHIIRIGRMGAGEKKNACSVQYRRPFGCAVLSIADLLTGETK
DDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVSLQLLHGDIEQIRREYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYIT
IERGEFEKGGKSVARNVEVTMFIVDSSGQTLKDFISFGSGEPPASEYHSFVLYHNNSPRWSELLKLPIPVDKFRGAHIRFEFRHCSTKEK
GEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKCEENTNLQDTTRYLKLPFSKGIFLGNNNQAMKATKESFCITSFLCSTKLTQNGDMLDL
LKWRTHPDKITGCLSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGSKVFDSLVHIINLLQDSKFHHFKPVMDTYIESHFAGALAYRD
LIKVLKWYVDRITEAERQEHIQEVLKAQEYIFKYIVQSRRLFSLATGGQNEEEFRCCIQELLMSVRFFLSQESKGSGALSQSQAVFLSSF
PAVYSELLKLFDVREVANLVQDTLGSLPTILHVDDSLQAIKLQCIGKTVESQLYTNPDSRYILLPVVLHHLHIHLQEQKDLIMCARILSN
VFCLIKKNSSEKSVLEEIDVIVASLLDILLRTILEITSRPQPSSSAMRFQFQDVTGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDF
LLQIFTVFRILIRPEMFPKDWTVMRLVANNVIITTVLYLSDALRKNFLNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKY
GDMRVTMGCEIFSMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMMDWEQRRSGNFKQVEAKLIDKLDSLMSEGKGDETY
RELFNSIIPLFGPYPSLLKKIERETWRESGVSLIATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYD
LHLKAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWENGIILCRKIAEQYESYYDYRNLSKMRMM
EASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLRNKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPI
PESQEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPGISRWFEVEKREVVEMSPLENAIEVLEN
KNQQLKTLISQCQTRQMQNINPLTMCLNGVIDAAVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQAQILEFGLAVHEKFVPQD
MRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASVSPDGTRVIPRRSPLSYPAVNRYSSSSLSSQASAEVSNIT
GQSESSDEVFNMQPSPSTSSLSSTHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPCSAIYPTPVEPSQRMLFNHIGDGALP
RSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLISPPVPPRPTQTASPARHTTSVSPSPAGRSPLKGSVQSFTPSPVEYHSPGLIS
NSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPLPVPVPVPVPSYGGEEPVRKESKTPPPYSVYERTLRRPVPLPHSLSIPVTSEP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PTPRZ1-DOCK4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PTPRZ1-DOCK4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTPRZ1-DOCK4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTPRZ1C0036341Schizophrenia3PSYGENET
HgenePTPRZ1C0004681Bagassosis1CTD_human
HgenePTPRZ1C0032273Pneumoconiosis1CTD_human
HgenePTPRZ1C0079487Helicobacter Infections1CTD_human
HgenePTPRZ1C1838332HELICOBACTER PYLORI INFECTION, SUSCEPTIBILITY TO1GENOMICS_ENGLAND
TgeneDOCK4C0036341Schizophrenia2PSYGENET
TgeneDOCK4C0004352Autistic Disorder1CTD_human