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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PTPRZ1-RCHY1 (FusionGDB2 ID:70150)

Fusion Gene Summary for PTPRZ1-RCHY1

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRZ1-RCHY1
Fusion gene ID: 70150
HgeneTgene
Gene symbol

PTPRZ1

RCHY1

Gene ID

5803

25898

Gene nameprotein tyrosine phosphatase receptor type Z1ring finger and CHY zinc finger domain containing 1
SynonymsHPTPZ|HPTPzeta|PTP-ZETA|PTP18|PTPRZ|PTPZ|R-PTP-zeta-2|RPTPB|RPTPbeta|phosphacanARNIP|CHIMP|PIRH2|PRO1996|RNF199|ZCHY|ZNF363
Cytomap

7q31.32

4q21.1

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase zetaprotein tyrosine phosphatase, receptor-type, Z polypeptide 1protein tyrosine phosphatase, receptor-type, zeta polypeptide 1protein-tyrosine phosphatase receptor type Z polypeptide 2receptor-type tyrosine RING finger and CHY zinc finger domain-containing protein 1CH-rich interacting match with PLAG1E3 ubiquitin-protein ligase Pirh2RING finger protein 199RING-type E3 ubiquitin transferase RCHY1androgen-receptor N-terminal-interacting proteinp53-induce
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000393386, ENST00000449182, 
ENST00000483028, 		ENST00000324439, 
ENST00000451788, ENST00000380840, 
ENST00000512706, ENST00000513257, 
ENST00000514021, 
Fusion gene scores* DoF score15 X 14 X 7=14704 X 4 X 3=48
# samples 194
** MAII scorelog2(19/1470*10)=-2.95174483139278
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPRZ1 [Title/Abstract] AND RCHY1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPTPRZ1(121671613)-RCHY1(76407876), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRCHY1

GO:0006511

ubiquitin-dependent protein catabolic process

19483087

TgeneRCHY1

GO:0016567

protein ubiquitination

19043414|19483087

TgeneRCHY1

GO:0031398

positive regulation of protein ubiquitination

19483087

TgeneRCHY1

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

19483087


check buttonFusion gene breakpoints across PTPRZ1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RCHY1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-76-4928-01BPTPRZ1chr7

121671613

+RCHY1chr4

76407876

-


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Fusion Gene ORF analysis for PTPRZ1-RCHY1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000393386ENST00000324439PTPRZ1chr7

121671613

+RCHY1chr4

76407876

-
5CDS-3UTRENST00000393386ENST00000451788PTPRZ1chr7

121671613

+RCHY1chr4

76407876

-
5CDS-3UTRENST00000393386ENST00000380840PTPRZ1chr7

121671613

+RCHY1chr4

76407876

-
5CDS-3UTRENST00000393386ENST00000512706PTPRZ1chr7

121671613

+RCHY1chr4

76407876

-
5CDS-3UTRENST00000393386ENST00000513257PTPRZ1chr7

121671613

+RCHY1chr4

76407876

-
5CDS-intronENST00000393386ENST00000514021PTPRZ1chr7

121671613

+RCHY1chr4

76407876

-
In-frameENST00000449182ENST00000324439PTPRZ1chr7

121671613

+RCHY1chr4

76407876

-
5CDS-3UTRENST00000449182ENST00000451788PTPRZ1chr7

121671613

+RCHY1chr4

76407876

-
5CDS-3UTRENST00000449182ENST00000380840PTPRZ1chr7

121671613

+RCHY1chr4

76407876

-
5CDS-3UTRENST00000449182ENST00000512706PTPRZ1chr7

121671613

+RCHY1chr4

76407876

-
5CDS-3UTRENST00000449182ENST00000513257PTPRZ1chr7

121671613

+RCHY1chr4

76407876

-
5CDS-intronENST00000449182ENST00000514021PTPRZ1chr7

121671613

+RCHY1chr4

76407876

-
intron-3CDSENST00000483028ENST00000324439PTPRZ1chr7

121671613

+RCHY1chr4

76407876

-
intron-3UTRENST00000483028ENST00000451788PTPRZ1chr7

121671613

+RCHY1chr4

76407876

-
intron-3UTRENST00000483028ENST00000380840PTPRZ1chr7

121671613

+RCHY1chr4

76407876

-
intron-3UTRENST00000483028ENST00000512706PTPRZ1chr7

121671613

+RCHY1chr4

76407876

-
intron-3UTRENST00000483028ENST00000513257PTPRZ1chr7

121671613

+RCHY1chr4

76407876

-
intron-intronENST00000483028ENST00000514021PTPRZ1chr7

121671613

+RCHY1chr4

76407876

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393386PTPRZ1chr7121671613+ENST00000324439RCHY1chr476407876-9207557719257051837
ENST00000449182PTPRZ1chr7121671613+ENST00000324439RCHY1chr476407876-63552725912853920

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393386ENST00000324439PTPRZ1chr7121671613+RCHY1chr476407876-0.0002108920.9997892
ENST00000449182ENST00000324439PTPRZ1chr7121671613+RCHY1chr476407876-6.41E-050.999936

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Fusion Genomic Features for PTPRZ1-RCHY1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PTPRZ1-RCHY1


check button Go to

FGviewer for the breakpoints of chr7:121671613-chr4:76407876

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPRZ1chr7:121671613chr4:76407876ENST00000393386+1530314_4131722.02316.0DomainFibronectin type-III
HgenePTPRZ1chr7:121671613chr4:76407876ENST00000393386+153036_3001722.02316.0DomainAlpha-carbonic anhydrase
HgenePTPRZ1chr7:121671613chr4:76407876ENST00000393386+153025_16361722.02316.0Topological domainExtracellular
HgenePTPRZ1chr7:121671613chr4:76407876ENST00000393386+15301637_16621722.02316.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPRZ1chr7:121671613chr4:76407876ENST00000393386+15301717_19921722.02316.0DomainTyrosine-protein phosphatase 1
HgenePTPRZ1chr7:121671613chr4:76407876ENST00000393386+15302023_22821722.02316.0DomainTyrosine-protein phosphatase 2
HgenePTPRZ1chr7:121671613chr4:76407876ENST00000393386+15301933_19391722.02316.0RegionSubstrate binding
HgenePTPRZ1chr7:121671613chr4:76407876ENST00000393386+15301663_23151722.02316.0Topological domainCytoplasmic
TgeneRCHY1chr7:121671613chr4:76407876ENST000003244397913_80219.0262.0Zinc fingerCHY-type
TgeneRCHY1chr7:121671613chr4:76407876ENST0000032443979145_189219.0262.0Zinc fingerRING-type
TgeneRCHY1chr7:121671613chr4:76407876ENST000003244397982_144219.0262.0Zinc fingerCTCHY-type
TgeneRCHY1chr7:121671613chr4:76407876ENST000005132576813_80210.0253.0Zinc fingerCHY-type
TgeneRCHY1chr7:121671613chr4:76407876ENST0000051325768145_189210.0253.0Zinc fingerRING-type
TgeneRCHY1chr7:121671613chr4:76407876ENST000005132576882_144210.0253.0Zinc fingerCTCHY-type


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Fusion Gene Sequence for PTPRZ1-RCHY1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000393386_ENST00000324439_TCGA-76-4928-01B_PTPRZ1_chr7_121671613_+_RCHY1_chr4_76407876_length(transcript)=9207nt_BP=5577nt
AGGAGCCGCGGCGCGCACAGCCGGGCTGGAGCGCGCACCCGGCACTGAGGCTTCGCTGCTCTCGGAGCGCTCAGACCGCGGCCGCCGCAG
CCGGCGAAAGAGGCAAAGTCCCGCACGCCGGAGGACATGCGCCTCGGCTAGCGGCCCCGGGCCCCACCACCGTGCGGCTTTCTCCAGATT
ATTCCTCTCTCGCTGTCTCTGACTGTCTCTCTCTGTCTCTGTCTCTGTCTCTCTCTCTCTCACACACACACACACACACACAAACACACA
TACGCACGCACGATCTCACTTCGATCTATACACTGGAGGATTAAAACAAACAAACAAAAAAAACATTTCCTTCGCTCCCCCTCCCTCTCC
ACTCTGAGAAGCAGAGGAGCCGCACGGCGAGGGGCCGCAGACCGTCTGGAAATGCGAATCCTAAAGCGTTTCCTCGCTTGCATTCAGCTC
CTCTGTGTTTGCCGCCTGGATTGGGCTAATGGATACTACAGACAACAGAGAAAACTTGTTGAAGAGATTGGCTGGTCCTATACAGGAGCA
CTGAATCAAAAAAATTGGGGAAAGAAATATCCAACATGTAATAGCCCAAAACAATCTCCTATCAATATTGATGAAGATCTTACACAAGTA
AATGTGAATCTTAAGAAACTTAAATTTCAGGGTTGGGATAAAACATCATTGGAAAACACATTCATTCATAACACTGGGAAAACAGTGGAA
ATTAATCTCACTAATGACTACCGTGTCAGCGGAGGAGTTTCAGAAATGGTGTTTAAAGCAAGCAAGATAACTTTTCACTGGGGAAAATGC
AATATGTCATCTGATGGATCAGAGCATAGTTTAGAAGGACAAAAATTTCCACTTGAGATGCAAATCTACTGCTTTGATGCGGACCGATTT
TCAAGTTTTGAGGAAGCAGTCAAAGGAAAAGGGAAGTTAAGAGCTTTATCCATTTTGTTTGAGGTTGGGACAGAAGAAAATTTGGATTTC
AAAGCGATTATTGATGGAGTCGAAAGTGTTAGTCGTTTTGGGAAGCAGGCTGCTTTAGATCCATTCATACTGTTGAACCTTCTGCCAAAC
TCAACTGACAAGTATTACATTTACAATGGCTCATTGACATCTCCTCCCTGCACAGACACAGTTGACTGGATTGTTTTTAAAGATACAGTT
AGCATCTCTGAAAGCCAGTTGGCTGTTTTTTGTGAAGTTCTTACAATGCAACAATCTGGTTATGTCATGCTGATGGACTACTTACAAAAC
AATTTTCGAGAGCAACAGTACAAGTTCTCTAGACAGGTGTTTTCCTCATACACTGGAAAGGAAGAGATTCATGAAGCAGTTTGTAGTTCA
GAACCAGAAAATGTTCAGGCTGACCCAGAGAATTATACCAGCCTTCTTGTTACATGGGAAAGACCTCGAGTCGTTTATGATACCATGATT
GAGAAGTTTGCAGTTTTGTACCAGCAGTTGGATGGAGAGGACCAAACCAAGCATGAATTTTTGACAGATGGCTATCAAGACTTGGGTGCT
ATTCTCAATAATTTGCTACCCAATATGAGTTATGTTCTTCAGATAGTAGCCATATGCACTAATGGCTTATATGGAAAATACAGCGACCAA
CTGATTGTCGACATGCCTACTGATAATCCTGAACTTGATCTTTTCCCTGAATTAATTGGAACTGAAGAAATAATCAAGGAGGAGGAAGAG
GGAAAAGACATTGAAGAAGGCGCTATTGTGAATCCTGGTAGAGACAGTGCTACAAACCAAATCAGGAAAAAGGAACCCCAGATTTCTACC
ACAACACACTACAATCGCATAGGGACGAAATACAATGAAGCCAAGACTAACCGATCCCCAACAAGAGGAAGTGAATTCTCTGGAAAGGGT
GATGTTCCCAATACATCTTTAAATTCCACTTCCCAACCAGTCACTAAATTAGCCACAGAAAAAGATATTTCCTTGACTTCTCAGACTGTG
ACTGAACTGCCACCTCACACTGTGGAAGGTACTTCAGCCTCTTTAAATGATGGCTCTAAAACTGTTCTTAGATCTCCACATATGAACTTG
TCGGGGACTGCAGAATCCTTAAATACAGTTTCTATAACAGAATATGAGGAGGAGAGTTTATTGACCAGTTTCAAGCTTGATACTGGAGCT
GAAGATTCTTCAGGCTCCAGTCCCGCAACTTCTGCTATCCCATTCATCTCTGAGAACATATCCCAAGGGTATATATTTTCCTCCGAAAAC
CCAGAGACAATAACATATGATGTCCTTATACCAGAATCTGCTAGAAATGCTTCCGAAGATTCAACTTCATCAGGTTCAGAAGAATCACTA
AAGGATCCTTCTATGGAGGGAAATGTGTGGTTTCCTAGCTCTACAGACATAACAGCACAGCCCGATGTTGGATCAGGCAGAGAGAGCTTT
CTCCAGACTAATTACACTGAGATACGTGTTGATGAATCTGAGAAGACAACCAAGTCCTTTTCTGCAGGCCCAGTGATGTCACAGGGTCCC
TCAGTTACAGATCTGGAAATGCCACATTATTCTACCTTTGCCTACTTCCCAACTGAGGTAACACCTCATGCTTTTACCCCATCCTCCAGA
CAACAGGATTTGGTCTCCACGGTCAACGTGGTATACTCGCAGACAACCCAACCGGTATACAATGGTGAGACACCTCTTCAACCTTCCTAC
AGTAGTGAAGTCTTTCCTCTAGTCACCCCTTTGTTGCTTGACAATCAGATCCTCAACACTACCCCTGCTGCTTCAAGTAGTGATTCGGCC
TTGCATGCTACGCCTGTATTTCCCAGTGTCGATGTGTCATTTGAATCCATCCTGTCTTCCTATGATGGTGCACCTTTGCTTCCATTTTCC
TCTGCTTCCTTCAGTAGTGAATTGTTTCGCCATCTGCATACAGTTTCTCAAATCCTTCCACAAGTTACTTCAGCTACCGAGAGTGATAAG
GTGCCCTTGCATGCTTCTCTGCCAGTGGCTGGGGGTGATTTGCTATTAGAGCCCAGCCTTGCTCAGTATTCTGATGTGCTGTCCACTACT
CATGCTGCTTCAGAGACGCTGGAATTTGGTAGTGAATCTGGTGTTCTTTATAAAACGCTTATGTTTTCTCAAGTTGAACCACCCAGCAGT
GATGCCATGATGCATGCACGTTCTTCAGGGCCTGAACCTTCTTATGCCTTGTCTGATAATGAGGGCTCCCAACACATCTTCACTGTTTCT
TACAGTTCTGCAATACCTGTGCATGATTCTGTGGGTGTAACTTATCAGGGTTCCTTATTTAGCGGCCCTAGCCATATACCAATACCTAAG
TCTTCGTTAATAACCCCAACTGCATCATTACTGCAGCCTACTCATGCCCTCTCTGGTGATGGGGAATGGTCTGGAGCCTCTTCTGATAGT
GAATTTCTTTTACCTGACACAGATGGGCTGACAGCCCTTAACATTTCTTCACCTGTTTCTGTAGCTGAATTTACATATACAACATCTGTG
TTTGGTGATGATAATAAGGCGCTTTCTAAAAGTGAAATAATATATGGAAATGAGACTGAACTGCAAATTCCTTCTTTCAATGAGATGGTT
TACCCTTCTGAAAGCACAGTCATGCCCAACATGTATGATAATGTAAATAAGTTGAATGCGTCTTTACAAGAAACCTCTGTTTCCATTTCT
AGCACCAAGGGCATGTTTCCAGGGTCCCTTGCTCATACCACCACTAAGGTTTTTGATCATGAGATTAGTCAAGTTCCAGAAAATAACTTT
TCAGTTCAACCTACACATACTGTCTCTCAAGCATCTGGTGACACTTCGCTTAAACCTGTGCTTAGTGCAAACTCAGAGCCAGCATCCTCT
GACCCTGCTTCTAGTGAAATGTTATCTCCTTCAACTCAGCTCTTATTTTATGAGACCTCAGCTTCTTTTAGTACTGAAGTATTGCTACAA
CCTTCCTTTCAGGCTTCTGATGTTGACACCTTGCTTAAAACTGTTCTTCCAGCTGTGCCCAGTGATCCAATATTGGTTGAAACCCCCAAA
GTTGATAAAATTAGTTCTACAATGTTGCATCTCATTGTATCAAATTCTGCTTCAAGTGAAAACATGCTGCACTCTACATCTGTACCAGTT
TTTGATGTGTCGCCTACTTCTCATATGCACTCTGCTTCACTTCAAGGTTTGACCATTTCCTATGCAAGTGAGAAATATGAACCAGTTTTG
TTAAAAAGTGAAAGTTCCCACCAAGTGGTACCTTCTTTGTACAGTAATGATGAGTTGTTCCAAACGGCCAATTTGGAGATTAACCAGGCC
CATCCCCCAAAAGGAAGGCATGTATTTGCTACACCTGTTTTATCAATTGATGAACCATTAAATACACTAATAAATAAGCTTATACATTCC
GATGAAATTTTAACCTCCACCAAAAGTTCTGTTACTGGTAAGGTATTTGCTGGTATTCCAACAGTTGCTTCTGATACATTTGTATCTACT
GATCATTCTGTTCCTATAGGAAATGGGCATGTTGCCATTACAGCTGTTTCTCCCCACAGAGATGGTTCTGTAACCTCAACAAAGTTGCTG
TTTCCTTCTAAGGCAACTTCTGAGCTGAGTCATAGTGCCAAATCTGATGCCGGTTTAGTGGGTGGTGGTGAAGATGGTGACACTGATGAT
GATGGTGATGATGATGATGATGACAGAGGTAGTGATGGCTTATCCATTCATAAGTGTATGTCATGCTCATCCTATAGAGAATCACAGGAA
AAGGTAATGAATGATTCAGACACCCACGAAAACAGTCTTATGGATCAGAATAATCCAATCTCATACTCACTATCTGAGAATTCTGAAGAA
GATAATAGAGTCACAAGTGTATCCTCAGACAGTCAAACTGGTATGGACAGAAGTCCTGGTAAATCACCATCAGCAAATGGGCTATCCCAA
AAGCACAATGATGGAAAAGAGGAAAATGACATTCAGACTGGTAGTGCTCTGCTTCCTCTCAGCCCTGAATCTAAAGCATGGGCAGTTCTG
ACAAGTGATGAAGAAAGTGGATCAGGGCAAGGTACCTCAGATAGCCTTAATGAGAATGAGACTTCCACAGATTTCAGTTTTGCAGACACT
AATGAAAAAGATGCTGATGGGATCCTGGCAGCAGGTGACTCAGAAATAACTCCTGGATTCCCACAGTCCCCAACATCATCTGTTACTAGC
GAGAACTCAGAAGTGTTCCACGTTTCAGAGGCAGAGGCCAGTAATAGTAGCCATGAGTCTCGTATTGGTCTAGCTGAGGGGTTGGAATCC
GAGAAGAAGGCAGTTATACCCCTTGTGATCGTGTCAGCCCTGACTTTTATCTGTCTAGTGGTTCTTGTGGGTATTCTCATCTACTGGAGG
AAATGCTTCCAGACTGCACACTTTTACTTAGAGGACAGTACATCCCCTAGAGTTATATCCACACCTCCAACACCTATCTTTCCAATTTCA
GATGATGTCGGAGCAATTCCAATAAAGCACTTTCCAAAGCATGTTGCAGATTTACATGCAAGTAGTGGGTTTACTGAAGAATTTGAGATT
CTCTGCAATGACTGTAATGGACGATCCACTGTTCAGTTTCATATATTAGGCATGAAATGTAAGATTTGTGAATCCTATAATACTGCTCAA
GCTGGAGGACGTAGAATTTCACTGGATCAGCAATGACGAGCCTACACAGTACTGGAGAACTTGGCATTTTCTGATATAGAAAAAGGCTTT
CCTTGGTATCGTGTTATCATGTGTCGTCATCTATGCATTAGAGTTGATGTGTTTTGTACTAGTGTCACAGCATAAAATCATATTACAAGT
ACGTAAGGATTCAGGGTCTCTTGATAGACTTATCATAGCTCTATATTGAATGAAAGCCACTGTGCTTGTGTTTTGATTGGAAATTCCTTT
AGTGTCAGTTTTTTGGAAGCCAATGATGTTTGCCACTGATACATTCATAGAAGTGTATTATATTTTCATGAAGCTTTGCTTTAAGTGACA
CTACGCGTGCAGTTCATTTCTAGTTCTTGATAGAACTGCACTTAATTTTCAGTAGTAGTCTTGACTTTTTAAGGGCTGTGTTATATTAAG
TTCTCCCTTACTGTTAAAACCTAATTAAATATGCTTTAGAATTTTCTAAGACAGTCCTCTGGATCCTCTAAATGTGAATTTTGATGTAAT
AACTGCTAATAAAATTATATTGAAACTGTTTTATAGAAAGTTTTTTCCAAAGTTTTCTATGTTTGGCTCAATTAGGGCAGTATCATCAGT
TCTATAATGTAAAAGAAATTTTCTTTCTTTTGAGGTATTCCATAAAAGTAGTTGGGAAAATTATTATGTAAAATAATAAGACTCTTCCAA
AGCCTTAATAAAAACATCAACATTGAAAACAGTTTTTTTTAGGTTGCCCAAAATTATTTCTTCAAAGAGTCATTCATTCCTTCATTTAGC
AAGTATTTATTGAGCAACTGCTATGTGGCAGATATGTTTCTAGATGCTGTAGAGACAACAGTGAACAATAAAGATAAAAGTCCTTGTCCT
CACAGCAGTACATTCTATTGTTCATCATATTTGATCAATGTACTCATTTTTCTTTATGCAAGGAGTGGATGTCTTATTGTAAATGAATAG
AATATTTCTTCCCTAAGCGTGTGAAAATAGGGGATGGATGAGTGGGAAGGGCATGGGATATTCCTGGCAAGATCTCTGATTTCATAATAC
TTTTTTGGGCTCATGTAGTGGAATTAAATATACCTCTTACTTCAGGAACAAAGTTAACAAATATGTTTGATGATCCAGCCGACTTTGACA
CTGTTATCTCCGTAATAGCTTTACCATTAGGCTAGGATGTAAAATGTACATTTATCAGTTGATAAGTACCTATTGAGCACCAGTTGTATT
TCCAACTTTGAGCTATTTGAATCTTCTTTGAATAAGGAAGTTAGCCTTTTAACTAGAAAGCCTAAGAGTTCTGGCACATTTATTTCTTCT
TTTGTTGAAATTTATTCACCTAGATAAAGGCAGCAGTTTGGGACTCAGATCTTTATTTTATCCCACCTTCTTGTCTTCTGTATTCCACTC
TTCTTATGTTCTTTCCCTTCATCTGTTTCCTTGGCCTGGCCAGAGCAGCAGTGCTGATCTTCATTTGGGAAAGGATGTTCCTGGGTATTA
CCAATTAGTATACAGATAAGTAAAGACTAGTTTTCCAGATCTAATACTTTTTTTTGAAGTGGTTTTGCTCTGTCATTTAGGCTAGAGTGT
AGTGAAGTGATCGTAGCTCACTGCAGCCTTGACTTCCTGGGCTGAACTGATCCTTCCACCTCAGCCTCCTGAGTAGCTGGGACTACAGGT
GTGTGCCACCATGCCCAGCTAATTTTTAATTGTTTTGTAGAAACAAAGTCCAGGCTGGTCTTGAACTCCTGGGCTCAAGCATTTCTCCTA
CCTCGGCCTTCCAAGGGCTAGGATTACAGGCATGAGCCACTGTGCTTGGTCCAGATGTATTACTTTTTATGTTTGGTATTATTCTGCCAA
ACCAATCATGTTATTGTTTTTAATCATTGAATCATTGGATCTTTAAATAGGAGTGAGTATATAATAATAAGGCTCTTCTGTTTTCAACAT
CTGTGCTGGGTCATGCATTAGCATTAATTACTACAATGATTCTGTGGGGTAAGTGTTGTCCTCATAGACAAGAAAGCTGAGGTTTAGAGG
TTAAAATGACACATTGGGGGTAAATAACAGACACTATATGTTGGAGTTGGGAATCAGATCCAAGTTTGACTCCAAACCCACTTTTACCAC
ATTGCTTTTGATCTAAACTTCTATTTTGCTAAAATACCCCTCACAGCTAGTCATCCATATCATTGAAGCGCTCATGATTTGATAGATTAA
CCTTTCATTTTTTTAGGTGACTCTAGTTAGAAAGTCTTATTTCACAATCTGATTGTTTCTTTAACTTAGGATCCAAACATGTCCAAAATA
ATGCAGAGTACATATGCAATCACTCGTTTATGCTGTCTAGTCATGCACTTAAAGCAATTTTCAAATGTACTCAAAGTCTCTAGGCTTCGG
TACCCAGGGTTGCTTCAAGTATTTGTTCATGACACGTCAACTCGATGATTAAAATCCTTCAACACTTCTCATTCACAATAAGAATAAAAT
CTACATCCCTTACCATTCAGTATGCAAAACTTAAAATACATAACTTTACCCTTAAATATTTTTTCTTTCTCTGACTTCATAAGTATAGGT
TATACCTCTATAAGAAAGAAGGTAAAAAACTCTCAACAATCCCTTCTTTCAGAGAGAACTACTGTTAACATTTTAACAGACAACTTCATT
CTTTTCCTATTCTTTTTTATAATGCTTACAGGAATGTTAAATACTTAGACAGATCTTAAGTACACTAGAATTATCTGTCCCTGAAATAAG
TTAGGTTGCCCTGCCGCAGAATTTGTATCTATAGTTTATTTGGATTATTTTTGAAAAAAGTAAAATAACAATACCCTTACGAATTTTTTG
GTGCATAGCATCTCAGCTTCTTTTATCATTAAAGATGTATGTATAAAAAAAAAATGAGTGTATATCAAGTTGTTCATTTCTTAGTTTCTG
GGGTCTTCTTAACCAGTACATAGAACTCTTTATGAATTAACTTTAGCTTATGTTGGAAGTAGTAGTTTGTTTATAGTGTCATGGATTTTA
AAATCAAACTCAGTTTTTATTTCTTCACTAAAACCTATTTTCATATGATATACATGTTAAATTTCCCTTTTATTTTGGTCATGCATCAAA
ATAAATTTACTAAGTACTAAAGAGCCAACATTATTTTATAAGTGCCTGGCAATAGGTATTCACTAGTTGAATAGTTTAATTTGAAATGAA
TTAATTTTAAATGGGAGTTGTTCAAAACTATGCCACTTTTTCTTTTGTCCTTTGTGTTATTAAAATTTAATTGATAATTGTGTATATTAT
ATATATGGAGTACAATGTGATGTTTTGATATATGTTTACAGTGTAGAATGATTAAATCAATGTAATAAATTTATTGCCTCATACCATTTT
TTGTGGTAAAAAAACCACTTAAAATCTACTCTTAATATTTTTGAAATGTACAATGCATTATTTATTATACTCACCATTCTGTGTAATAGA

>In-frame_ENST00000393386_ENST00000324439_TCGA-76-4928-01B_PTPRZ1_chr7_121671613_+_RCHY1_chr4_76407876_length(amino acids)=1837AA_start in transcript=192_stop in transcript=5705
MSLTVSLCLCLCLSLSHTHTHTHKHTYARTISLRSIHWRIKTNKQKKHFLRSPSLSTLRSRGAARRGAADRLEMRILKRFLACIQLLCVC
RLDWANGYYRQQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPKQSPINIDEDLTQVNVNLKKLKFQGWDKTSLENTFIHNTGKTVEINLT
NDYRVSGGVSEMVFKASKITFHWGKCNMSSDGSEHSLEGQKFPLEMQIYCFDADRFSSFEEAVKGKGKLRALSILFEVGTEENLDFKAII
DGVESVSRFGKQAALDPFILLNLLPNSTDKYYIYNGSLTSPPCTDTVDWIVFKDTVSISESQLAVFCEVLTMQQSGYVMLMDYLQNNFRE
QQYKFSRQVFSSYTGKEEIHEAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEFLTDGYQDLGAILNN
LLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPTDNPELDLFPELIGTEEIIKEEEEGKDIEEGAIVNPGRDSATNQIRKKEPQISTTTHY
NRIGTKYNEAKTNRSPTRGSEFSGKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVTELPPHTVEGTSASLNDGSKTVLRSPHMNLSGTA
ESLNTVSITEYEEESLLTSFKLDTGAEDSSGSSPATSAIPFISENISQGYIFSSENPETITYDVLIPESARNASEDSTSSGSEESLKDPS
MEGNVWFPSSTDITAQPDVGSGRESFLQTNYTEIRVDESEKTTKSFSAGPVMSQGPSVTDLEMPHYSTFAYFPTEVTPHAFTPSSRQQDL
VSTVNVVYSQTTQPVYNGETPLQPSYSSEVFPLVTPLLLDNQILNTTPAASSSDSALHATPVFPSVDVSFESILSSYDGAPLLPFSSASF
SSELFRHLHTVSQILPQVTSATESDKVPLHASLPVAGGDLLLEPSLAQYSDVLSTTHAASETLEFGSESGVLYKTLMFSQVEPPSSDAMM
HARSSGPEPSYALSDNEGSQHIFTVSYSSAIPVHDSVGVTYQGSLFSGPSHIPIPKSSLITPTASLLQPTHALSGDGEWSGASSDSEFLL
PDTDGLTALNISSPVSVAEFTYTTSVFGDDNKALSKSEIIYGNETELQIPSFNEMVYPSESTVMPNMYDNVNKLNASLQETSVSISSTKG
MFPGSLAHTTTKVFDHEISQVPENNFSVQPTHTVSQASGDTSLKPVLSANSEPASSDPASSEMLSPSTQLLFYETSASFSTEVLLQPSFQ
ASDVDTLLKTVLPAVPSDPILVETPKVDKISSTMLHLIVSNSASSENMLHSTSVPVFDVSPTSHMHSASLQGLTISYASEKYEPVLLKSE
SSHQVVPSLYSNDELFQTANLEINQAHPPKGRHVFATPVLSIDEPLNTLINKLIHSDEILTSTKSSVTGKVFAGIPTVASDTFVSTDHSV
PIGNGHVAITAVSPHRDGSVTSTKLLFPSKATSELSHSAKSDAGLVGGGEDGDTDDDGDDDDDDRGSDGLSIHKCMSCSSYRESQEKVMN
DSDTHENSLMDQNNPISYSLSENSEEDNRVTSVSSDSQTGMDRSPGKSPSANGLSQKHNDGKEENDIQTGSALLPLSPESKAWAVLTSDE
ESGSGQGTSDSLNENETSTDFSFADTNEKDADGILAAGDSEITPGFPQSPTSSVTSENSEVFHVSEAEASNSSHESRIGLAEGLESEKKA
VIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFEILCND

--------------------------------------------------------------
>In-frame_ENST00000449182_ENST00000324439_TCGA-76-4928-01B_PTPRZ1_chr7_121671613_+_RCHY1_chr4_76407876_length(transcript)=6355nt_BP=2725nt
CGCACGCACGATCTCACTTCGATCTATACACTGGAGGATTAAAACAAACAAACAAAAAAAACATTTCCTTCGCTCCCCCTCCCTCTCCAC
TCTGAGAAGCAGAGGAGCCGCACGGCGAGGGGCCGCAGACCGTCTGGAAATGCGAATCCTAAAGCGTTTCCTCGCTTGCATTCAGCTCCT
CTGTGTTTGCCGCCTGGATTGGGCTAATGGATACTACAGACAACAGAGAAAACTTGTTGAAGAGATTGGCTGGTCCTATACAGGAGCACT
GAATCAAAAAAATTGGGGAAAGAAATATCCAACATGTAATAGCCCAAAACAATCTCCTATCAATATTGATGAAGATCTTACACAAGTAAA
TGTGAATCTTAAGAAACTTAAATTTCAGGGTTGGGATAAAACATCATTGGAAAACACATTCATTCATAACACTGGGAAAACAGTGGAAAT
TAATCTCACTAATGACTACCGTGTCAGCGGAGGAGTTTCAGAAATGGTGTTTAAAGCAAGCAAGATAACTTTTCACTGGGGAAAATGCAA
TATGTCATCTGATGGATCAGAGCATAGTTTAGAAGGACAAAAATTTCCACTTGAGATGCAAATCTACTGCTTTGATGCGGACCGATTTTC
AAGTTTTGAGGAAGCAGTCAAAGGAAAAGGGAAGTTAAGAGCTTTATCCATTTTGTTTGAGGTTGGGACAGAAGAAAATTTGGATTTCAA
AGCGATTATTGATGGAGTCGAAAGTGTTAGTCGTTTTGGGAAGCAGGCTGCTTTAGATCCATTCATACTGTTGAACCTTCTGCCAAACTC
AACTGACAAGTATTACATTTACAATGGCTCATTGACATCTCCTCCCTGCACAGACACAGTTGACTGGATTGTTTTTAAAGATACAGTTAG
CATCTCTGAAAGCCAGTTGGCTGTTTTTTGTGAAGTTCTTACAATGCAACAATCTGGTTATGTCATGCTGATGGACTACTTACAAAACAA
TTTTCGAGAGCAACAGTACAAGTTCTCTAGACAGGTGTTTTCCTCATACACTGGAAAGGAAGAGATTCATGAAGCAGTTTGTAGTTCAGA
ACCAGAAAATGTTCAGGCTGACCCAGAGAATTATACCAGCCTTCTTGTTACATGGGAAAGACCTCGAGTCGTTTATGATACCATGATTGA
GAAGTTTGCAGTTTTGTACCAGCAGTTGGATGGAGAGGACCAAACCAAGCATGAATTTTTGACAGATGGCTATCAAGACTTGGGTGCTAT
TCTCAATAATTTGCTACCCAATATGAGTTATGTTCTTCAGATAGTAGCCATATGCACTAATGGCTTATATGGAAAATACAGCGACCAACT
GATTGTCGACATGCCTACTGATAATCCTGAACTTGATCTTTTCCCTGAATTAATTGGAACTGAAGAAATAATCAAGGAGGAGGAAGAGGG
AAAAGACATTGAAGAAGGCGCTATTGTGAATCCTGGTAGAGACAGTGCTACAAACCAAATCAGGAAAAAGGAACCCCAGATTTCTACCAC
AACACACTACAATCGCATAGGGACGAAATACAATGAAGCCAAGACTAACCGATCCCCAACAAGAGGAAGTGAATTCTCTGGAAAGGGTGA
TGTTCCCAATACATCTTTAAATTCCACTTCCCAACCAGTCACTAAATTAGCCACAGAAAAAGATATTTCCTTGACTTCTCAGACTGTGAC
TGAACTGCCACCTCACACTGTGGAAGGTACTTCAGCCTCTTTAAATGATGGCTCTAAAACTGTTCTTAGATCTCCACATATGAACTTGTC
GGGGACTGCAGAATCCTTAAATACAGTTTCTATAACAGAATATGAGGAGGAGAGTTTATTGACCAGTTTCAAGCTTGATACTGGAGCTGA
AGATTCTTCAGGCTCCAGTCCCGCAACTTCTGCTATCCCATTCATCTCTGAGAACATATCCCAAGGGTATATATTTTCCTCCGAAAACCC
AGAGACAATAACATATGATGTCCTTATACCAGAATCTGCTAGAAATGCTTCCGAAGATTCAACTTCATCAGGTTCAGAAGAATCACTAAA
GGATCCTTCTATGGAGGGAAATGTGTGGTTTCCTAGCTCTACAGACATAACAGCACAGCCCGATGTTGGATCAGGCAGAGAGAGCTTTCT
CCAGACTAATTACACTGAGATACGTGTTGATGAATCTGAGAAGACAACCAAGTCCTTTTCTGCAGGCCCAGTGATGTCACAGGGTCCCTC
AGTTACAGATCTGGAAATGCCACATTATTCTACCTTTGCCTACTTCCCAACTGAGGTAACACCTCATGCTTTTACCCCATCCTCCAGACA
ACAGGATTTGGTCTCCACGGTCAACGTGGTATACTCGCAGACAACCCAACCGGTATACAATGAGGCCAGTAATAGTAGCCATGAGTCTCG
TATTGGTCTAGCTGAGGGGTTGGAATCCGAGAAGAAGGCAGTTATACCCCTTGTGATCGTGTCAGCCCTGACTTTTATCTGTCTAGTGGT
TCTTGTGGGTATTCTCATCTACTGGAGGAAATGCTTCCAGACTGCACACTTTTACTTAGAGGACAGTACATCCCCTAGAGTTATATCCAC
ACCTCCAACACCTATCTTTCCAATTTCAGATGATGTCGGAGCAATTCCAATAAAGCACTTTCCAAAGCATGTTGCAGATTTACATGCAAG
TAGTGGGTTTACTGAAGAATTTGAGATTCTCTGCAATGACTGTAATGGACGATCCACTGTTCAGTTTCATATATTAGGCATGAAATGTAA
GATTTGTGAATCCTATAATACTGCTCAAGCTGGAGGACGTAGAATTTCACTGGATCAGCAATGACGAGCCTACACAGTACTGGAGAACTT
GGCATTTTCTGATATAGAAAAAGGCTTTCCTTGGTATCGTGTTATCATGTGTCGTCATCTATGCATTAGAGTTGATGTGTTTTGTACTAG
TGTCACAGCATAAAATCATATTACAAGTACGTAAGGATTCAGGGTCTCTTGATAGACTTATCATAGCTCTATATTGAATGAAAGCCACTG
TGCTTGTGTTTTGATTGGAAATTCCTTTAGTGTCAGTTTTTTGGAAGCCAATGATGTTTGCCACTGATACATTCATAGAAGTGTATTATA
TTTTCATGAAGCTTTGCTTTAAGTGACACTACGCGTGCAGTTCATTTCTAGTTCTTGATAGAACTGCACTTAATTTTCAGTAGTAGTCTT
GACTTTTTAAGGGCTGTGTTATATTAAGTTCTCCCTTACTGTTAAAACCTAATTAAATATGCTTTAGAATTTTCTAAGACAGTCCTCTGG
ATCCTCTAAATGTGAATTTTGATGTAATAACTGCTAATAAAATTATATTGAAACTGTTTTATAGAAAGTTTTTTCCAAAGTTTTCTATGT
TTGGCTCAATTAGGGCAGTATCATCAGTTCTATAATGTAAAAGAAATTTTCTTTCTTTTGAGGTATTCCATAAAAGTAGTTGGGAAAATT
ATTATGTAAAATAATAAGACTCTTCCAAAGCCTTAATAAAAACATCAACATTGAAAACAGTTTTTTTTAGGTTGCCCAAAATTATTTCTT
CAAAGAGTCATTCATTCCTTCATTTAGCAAGTATTTATTGAGCAACTGCTATGTGGCAGATATGTTTCTAGATGCTGTAGAGACAACAGT
GAACAATAAAGATAAAAGTCCTTGTCCTCACAGCAGTACATTCTATTGTTCATCATATTTGATCAATGTACTCATTTTTCTTTATGCAAG
GAGTGGATGTCTTATTGTAAATGAATAGAATATTTCTTCCCTAAGCGTGTGAAAATAGGGGATGGATGAGTGGGAAGGGCATGGGATATT
CCTGGCAAGATCTCTGATTTCATAATACTTTTTTGGGCTCATGTAGTGGAATTAAATATACCTCTTACTTCAGGAACAAAGTTAACAAAT
ATGTTTGATGATCCAGCCGACTTTGACACTGTTATCTCCGTAATAGCTTTACCATTAGGCTAGGATGTAAAATGTACATTTATCAGTTGA
TAAGTACCTATTGAGCACCAGTTGTATTTCCAACTTTGAGCTATTTGAATCTTCTTTGAATAAGGAAGTTAGCCTTTTAACTAGAAAGCC
TAAGAGTTCTGGCACATTTATTTCTTCTTTTGTTGAAATTTATTCACCTAGATAAAGGCAGCAGTTTGGGACTCAGATCTTTATTTTATC
CCACCTTCTTGTCTTCTGTATTCCACTCTTCTTATGTTCTTTCCCTTCATCTGTTTCCTTGGCCTGGCCAGAGCAGCAGTGCTGATCTTC
ATTTGGGAAAGGATGTTCCTGGGTATTACCAATTAGTATACAGATAAGTAAAGACTAGTTTTCCAGATCTAATACTTTTTTTTGAAGTGG
TTTTGCTCTGTCATTTAGGCTAGAGTGTAGTGAAGTGATCGTAGCTCACTGCAGCCTTGACTTCCTGGGCTGAACTGATCCTTCCACCTC
AGCCTCCTGAGTAGCTGGGACTACAGGTGTGTGCCACCATGCCCAGCTAATTTTTAATTGTTTTGTAGAAACAAAGTCCAGGCTGGTCTT
GAACTCCTGGGCTCAAGCATTTCTCCTACCTCGGCCTTCCAAGGGCTAGGATTACAGGCATGAGCCACTGTGCTTGGTCCAGATGTATTA
CTTTTTATGTTTGGTATTATTCTGCCAAACCAATCATGTTATTGTTTTTAATCATTGAATCATTGGATCTTTAAATAGGAGTGAGTATAT
AATAATAAGGCTCTTCTGTTTTCAACATCTGTGCTGGGTCATGCATTAGCATTAATTACTACAATGATTCTGTGGGGTAAGTGTTGTCCT
CATAGACAAGAAAGCTGAGGTTTAGAGGTTAAAATGACACATTGGGGGTAAATAACAGACACTATATGTTGGAGTTGGGAATCAGATCCA
AGTTTGACTCCAAACCCACTTTTACCACATTGCTTTTGATCTAAACTTCTATTTTGCTAAAATACCCCTCACAGCTAGTCATCCATATCA
TTGAAGCGCTCATGATTTGATAGATTAACCTTTCATTTTTTTAGGTGACTCTAGTTAGAAAGTCTTATTTCACAATCTGATTGTTTCTTT
AACTTAGGATCCAAACATGTCCAAAATAATGCAGAGTACATATGCAATCACTCGTTTATGCTGTCTAGTCATGCACTTAAAGCAATTTTC
AAATGTACTCAAAGTCTCTAGGCTTCGGTACCCAGGGTTGCTTCAAGTATTTGTTCATGACACGTCAACTCGATGATTAAAATCCTTCAA
CACTTCTCATTCACAATAAGAATAAAATCTACATCCCTTACCATTCAGTATGCAAAACTTAAAATACATAACTTTACCCTTAAATATTTT
TTCTTTCTCTGACTTCATAAGTATAGGTTATACCTCTATAAGAAAGAAGGTAAAAAACTCTCAACAATCCCTTCTTTCAGAGAGAACTAC
TGTTAACATTTTAACAGACAACTTCATTCTTTTCCTATTCTTTTTTATAATGCTTACAGGAATGTTAAATACTTAGACAGATCTTAAGTA
CACTAGAATTATCTGTCCCTGAAATAAGTTAGGTTGCCCTGCCGCAGAATTTGTATCTATAGTTTATTTGGATTATTTTTGAAAAAAGTA
AAATAACAATACCCTTACGAATTTTTTGGTGCATAGCATCTCAGCTTCTTTTATCATTAAAGATGTATGTATAAAAAAAAAATGAGTGTA
TATCAAGTTGTTCATTTCTTAGTTTCTGGGGTCTTCTTAACCAGTACATAGAACTCTTTATGAATTAACTTTAGCTTATGTTGGAAGTAG
TAGTTTGTTTATAGTGTCATGGATTTTAAAATCAAACTCAGTTTTTATTTCTTCACTAAAACCTATTTTCATATGATATACATGTTAAAT
TTCCCTTTTATTTTGGTCATGCATCAAAATAAATTTACTAAGTACTAAAGAGCCAACATTATTTTATAAGTGCCTGGCAATAGGTATTCA
CTAGTTGAATAGTTTAATTTGAAATGAATTAATTTTAAATGGGAGTTGTTCAAAACTATGCCACTTTTTCTTTTGTCCTTTGTGTTATTA
AAATTTAATTGATAATTGTGTATATTATATATATGGAGTACAATGTGATGTTTTGATATATGTTTACAGTGTAGAATGATTAAATCAATG
TAATAAATTTATTGCCTCATACCATTTTTTGTGGTAAAAAAACCACTTAAAATCTACTCTTAATATTTTTGAAATGTACAATGCATTATT

>In-frame_ENST00000449182_ENST00000324439_TCGA-76-4928-01B_PTPRZ1_chr7_121671613_+_RCHY1_chr4_76407876_length(amino acids)=920AA_start in transcript=91_stop in transcript=2853
MRSRGAARRGAADRLEMRILKRFLACIQLLCVCRLDWANGYYRQQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPKQSPINIDEDLTQVN
VNLKKLKFQGWDKTSLENTFIHNTGKTVEINLTNDYRVSGGVSEMVFKASKITFHWGKCNMSSDGSEHSLEGQKFPLEMQIYCFDADRFS
SFEEAVKGKGKLRALSILFEVGTEENLDFKAIIDGVESVSRFGKQAALDPFILLNLLPNSTDKYYIYNGSLTSPPCTDTVDWIVFKDTVS
ISESQLAVFCEVLTMQQSGYVMLMDYLQNNFREQQYKFSRQVFSSYTGKEEIHEAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIE
KFAVLYQQLDGEDQTKHEFLTDGYQDLGAILNNLLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPTDNPELDLFPELIGTEEIIKEEEEG
KDIEEGAIVNPGRDSATNQIRKKEPQISTTTHYNRIGTKYNEAKTNRSPTRGSEFSGKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVT
ELPPHTVEGTSASLNDGSKTVLRSPHMNLSGTAESLNTVSITEYEEESLLTSFKLDTGAEDSSGSSPATSAIPFISENISQGYIFSSENP
ETITYDVLIPESARNASEDSTSSGSEESLKDPSMEGNVWFPSSTDITAQPDVGSGRESFLQTNYTEIRVDESEKTTKSFSAGPVMSQGPS
VTDLEMPHYSTFAYFPTEVTPHAFTPSSRQQDLVSTVNVVYSQTTQPVYNEASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFICLVV
LVGILIYWRKCFQTAHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFEILCNDCNGRSTVQFHILGMKCK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PTPRZ1-RCHY1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PTPRZ1-RCHY1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PTPRZ1-RCHY1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTPRZ1C0036341Schizophrenia3PSYGENET
HgenePTPRZ1C0004681Bagassosis1CTD_human
HgenePTPRZ1C0032273Pneumoconiosis1CTD_human
HgenePTPRZ1C0079487Helicobacter Infections1CTD_human
HgenePTPRZ1C1838332HELICOBACTER PYLORI INFECTION, SUSCEPTIBILITY TO1GENOMICS_ENGLAND
TgeneRCHY1C0024121Lung Neoplasms1CTD_human
TgeneRCHY1C0235874Disease Exacerbation1CTD_human
TgeneRCHY1C0242379Malignant neoplasm of lung1CTD_human