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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PUM1-PPP1R1B (FusionGDB2 ID:70241)

Fusion Gene Summary for PUM1-PPP1R1B

check button Fusion gene summary
Fusion gene informationFusion gene name: PUM1-PPP1R1B
Fusion gene ID: 70241
HgeneTgene
Gene symbol

PUM1

PPP1R1B

Gene ID

9698

84152

Gene namepumilio RNA binding family member 1protein phosphatase 1 regulatory inhibitor subunit 1B
SynonymsHSPUM|PUMH|PUMH1|PUML1|SCA47DARPP-32|DARPP32
Cytomap

1p35.2

17q12

Type of geneprotein-codingprotein-coding
Descriptionpumilio homolog 1pumilio-1protein phosphatase 1 regulatory subunit 1Bdopamine and cAMP-regulated neuronal phosphoprotein 32
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000424085, ENST00000257075, 
ENST00000373747, ENST00000426105, 
ENST00000440538, ENST00000373741, 
ENST00000423018, ENST00000373742, 
ENST00000490546, 		ENST00000580825, 
ENST00000254079, ENST00000579000, 
ENST00000394265, ENST00000394267, 
Fusion gene scores* DoF score38 X 31 X 15=1767017 X 10 X 9=1530
# samples 5626
** MAII scorelog2(56/17670*10)=-4.97973140249401
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/1530*10)=-2.55694812455156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PUM1 [Title/Abstract] AND PPP1R1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPUM1(31425080)-PPP1R1B(37785422), # samples:1
Anticipated loss of major functional domain due to fusion event.PUM1-PPP1R1B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PUM1-PPP1R1B seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePUM1

GO:0010608

posttranscriptional regulation of gene expression

25100735

HgenePUM1

GO:0043488

regulation of mRNA stability

26724866

HgenePUM1

GO:0051726

regulation of cell cycle

20818387

HgenePUM1

GO:0051983

regulation of chromosome segregation

26724866

HgenePUM1

GO:1900246

positive regulation of RIG-I signaling pathway

25340845

HgenePUM1

GO:2000637

positive regulation of gene silencing by miRNA

20818387|22345517

TgenePPP1R1B

GO:0032515

negative regulation of phosphoprotein phosphatase activity

10807923


check buttonFusion gene breakpoints across PUM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PPP1R1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-R6-A8W5PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+


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Fusion Gene ORF analysis for PUM1-PPP1R1B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000424085ENST00000580825PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
Frame-shiftENST00000424085ENST00000254079PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
Frame-shiftENST00000424085ENST00000579000PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
5CDS-5UTRENST00000424085ENST00000394265PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
5CDS-5UTRENST00000424085ENST00000394267PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
Frame-shiftENST00000257075ENST00000580825PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
Frame-shiftENST00000257075ENST00000254079PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
Frame-shiftENST00000257075ENST00000579000PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
5CDS-5UTRENST00000257075ENST00000394265PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
5CDS-5UTRENST00000257075ENST00000394267PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
Frame-shiftENST00000373747ENST00000580825PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
Frame-shiftENST00000373747ENST00000254079PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
Frame-shiftENST00000373747ENST00000579000PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
5CDS-5UTRENST00000373747ENST00000394265PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
5CDS-5UTRENST00000373747ENST00000394267PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
Frame-shiftENST00000426105ENST00000580825PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
Frame-shiftENST00000426105ENST00000254079PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
Frame-shiftENST00000426105ENST00000579000PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
5CDS-5UTRENST00000426105ENST00000394265PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
5CDS-5UTRENST00000426105ENST00000394267PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
Frame-shiftENST00000440538ENST00000580825PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
Frame-shiftENST00000440538ENST00000254079PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
Frame-shiftENST00000440538ENST00000579000PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
5CDS-5UTRENST00000440538ENST00000394265PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
5CDS-5UTRENST00000440538ENST00000394267PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
In-frameENST00000373741ENST00000580825PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
In-frameENST00000373741ENST00000254079PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
In-frameENST00000373741ENST00000579000PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
5CDS-5UTRENST00000373741ENST00000394265PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
5CDS-5UTRENST00000373741ENST00000394267PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
Frame-shiftENST00000423018ENST00000580825PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
Frame-shiftENST00000423018ENST00000254079PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
Frame-shiftENST00000423018ENST00000579000PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
5CDS-5UTRENST00000423018ENST00000394265PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
5CDS-5UTRENST00000423018ENST00000394267PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
In-frameENST00000373742ENST00000580825PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
In-frameENST00000373742ENST00000254079PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
In-frameENST00000373742ENST00000579000PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
5CDS-5UTRENST00000373742ENST00000394265PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
5CDS-5UTRENST00000373742ENST00000394267PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
intron-3CDSENST00000490546ENST00000580825PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
intron-3CDSENST00000490546ENST00000254079PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
intron-3CDSENST00000490546ENST00000579000PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
intron-5UTRENST00000490546ENST00000394265PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+
intron-5UTRENST00000490546ENST00000394267PUM1chr1

31425080

-PPP1R1Bchr17

37785422

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373741PUM1chr131425080-ENST00000580825PPP1R1Bchr1737785422+3704303511335681151
ENST00000373741PUM1chr131425080-ENST00000254079PPP1R1Bchr1737785422+4330303511335681151
ENST00000373741PUM1chr131425080-ENST00000579000PPP1R1Bchr1737785422+4227303511334691118
ENST00000373742PUM1chr131425080-ENST00000580825PPP1R1Bchr1737785422+32132544030771025
ENST00000373742PUM1chr131425080-ENST00000254079PPP1R1Bchr1737785422+38392544030771025
ENST00000373742PUM1chr131425080-ENST00000579000PPP1R1Bchr1737785422+3736254402978992

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373741ENST00000580825PUM1chr131425080-PPP1R1Bchr1737785422+0.009824330.99017566
ENST00000373741ENST00000254079PUM1chr131425080-PPP1R1Bchr1737785422+0.0057378310.9942622
ENST00000373741ENST00000579000PUM1chr131425080-PPP1R1Bchr1737785422+0.0053853060.99461466
ENST00000373742ENST00000580825PUM1chr131425080-PPP1R1Bchr1737785422+0.0109607870.9890392
ENST00000373742ENST00000254079PUM1chr131425080-PPP1R1Bchr1737785422+0.0061003770.9938996
ENST00000373742ENST00000579000PUM1chr131425080-PPP1R1Bchr1737785422+0.0047362950.9952637

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Fusion Genomic Features for PUM1-PPP1R1B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PUM1chr131425080-PPP1R1Bchr1737785422+2.58E-060.9999974
PUM1chr131425080-PPP1R1Bchr1737785422+2.58E-060.9999974

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PUM1-PPP1R1B


check button Go to

FGviewer for the breakpoints of chr1:31425080-chr17:37785422

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePUM1chr1:31425080chr17:37785422ENST00000257075-1622393_613907.01187.0Compositional biasNote=Ala-rich
HgenePUM1chr1:31425080chr17:37785422ENST00000257075-1622475_523907.01187.0Compositional biasNote=Gln-rich
HgenePUM1chr1:31425080chr17:37785422ENST00000257075-1622642_815907.01187.0Compositional biasNote=Ser-rich
HgenePUM1chr1:31425080chr17:37785422ENST00000426105-1622393_613907.01189.0Compositional biasNote=Ala-rich
HgenePUM1chr1:31425080chr17:37785422ENST00000426105-1622475_523907.01189.0Compositional biasNote=Gln-rich
HgenePUM1chr1:31425080chr17:37785422ENST00000426105-1622642_815907.01189.0Compositional biasNote=Ser-rich
HgenePUM1chr1:31425080chr17:37785422ENST00000440538-1622393_613881.01163.0Compositional biasNote=Ala-rich
HgenePUM1chr1:31425080chr17:37785422ENST00000440538-1622475_523881.01163.0Compositional biasNote=Gln-rich
HgenePUM1chr1:31425080chr17:37785422ENST00000440538-1622642_815881.01163.0Compositional biasNote=Ser-rich
HgenePUM1chr1:31425080chr17:37785422ENST00000257075-1622848_883907.01187.0RepeatPumilio 1
HgenePUM1chr1:31425080chr17:37785422ENST00000426105-1622848_883907.01189.0RepeatPumilio 1
HgenePUM1chr1:31425080chr17:37785422ENST00000440538-1622848_883881.01163.0RepeatPumilio 1
TgenePPP1R1Bchr1:31425080chr17:37785422ENST0000025407907119_13627.0205.0Compositional biasNote=Asp/Glu-rich (acidic)
TgenePPP1R1Bchr1:31425080chr17:37785422ENST0000039426507119_1360169.0Compositional biasNote=Asp/Glu-rich (acidic)
TgenePPP1R1Bchr1:31425080chr17:37785422ENST0000039426707119_1360169.0Compositional biasNote=Asp/Glu-rich (acidic)
TgenePPP1R1Bchr1:31425080chr17:37785422ENST0000058082518119_13627.0205.0Compositional biasNote=Asp/Glu-rich (acidic)

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePUM1chr1:31425080chr17:37785422ENST00000257075-1622828_1168907.01187.0DomainPUM-HD
HgenePUM1chr1:31425080chr17:37785422ENST00000426105-1622828_1168907.01189.0DomainPUM-HD
HgenePUM1chr1:31425080chr17:37785422ENST00000440538-1622828_1168881.01163.0DomainPUM-HD
HgenePUM1chr1:31425080chr17:37785422ENST00000257075-16221028_1063907.01187.0RepeatPumilio 6
HgenePUM1chr1:31425080chr17:37785422ENST00000257075-16221064_1099907.01187.0RepeatPumilio 7
HgenePUM1chr1:31425080chr17:37785422ENST00000257075-16221103_1142907.01187.0RepeatPumilio 8
HgenePUM1chr1:31425080chr17:37785422ENST00000257075-1622884_919907.01187.0RepeatPumilio 2
HgenePUM1chr1:31425080chr17:37785422ENST00000257075-1622920_955907.01187.0RepeatPumilio 3
HgenePUM1chr1:31425080chr17:37785422ENST00000257075-1622956_991907.01187.0RepeatPumilio 4
HgenePUM1chr1:31425080chr17:37785422ENST00000257075-1622992_1027907.01187.0RepeatPumilio 5
HgenePUM1chr1:31425080chr17:37785422ENST00000426105-16221028_1063907.01189.0RepeatPumilio 6
HgenePUM1chr1:31425080chr17:37785422ENST00000426105-16221064_1099907.01189.0RepeatPumilio 7
HgenePUM1chr1:31425080chr17:37785422ENST00000426105-16221103_1142907.01189.0RepeatPumilio 8
HgenePUM1chr1:31425080chr17:37785422ENST00000426105-1622884_919907.01189.0RepeatPumilio 2
HgenePUM1chr1:31425080chr17:37785422ENST00000426105-1622920_955907.01189.0RepeatPumilio 3
HgenePUM1chr1:31425080chr17:37785422ENST00000426105-1622956_991907.01189.0RepeatPumilio 4
HgenePUM1chr1:31425080chr17:37785422ENST00000426105-1622992_1027907.01189.0RepeatPumilio 5
HgenePUM1chr1:31425080chr17:37785422ENST00000440538-16221028_1063881.01163.0RepeatPumilio 6
HgenePUM1chr1:31425080chr17:37785422ENST00000440538-16221064_1099881.01163.0RepeatPumilio 7
HgenePUM1chr1:31425080chr17:37785422ENST00000440538-16221103_1142881.01163.0RepeatPumilio 8
HgenePUM1chr1:31425080chr17:37785422ENST00000440538-1622884_919881.01163.0RepeatPumilio 2
HgenePUM1chr1:31425080chr17:37785422ENST00000440538-1622920_955881.01163.0RepeatPumilio 3
HgenePUM1chr1:31425080chr17:37785422ENST00000440538-1622956_991881.01163.0RepeatPumilio 4
HgenePUM1chr1:31425080chr17:37785422ENST00000440538-1622992_1027881.01163.0RepeatPumilio 5


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Fusion Gene Sequence for PUM1-PPP1R1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000373741_ENST00000580825_TCGA-R6-A8W5_PUM1_chr1_31425080_-_PPP1R1B_chr17_37785422_length(transcript)=3704nt_BP=3035nt
AACCCCGCGTGCCCAGCTCCAGGCCGTGTTCTCCCAGGTGCGGGCCGGCGGGACCCCGCCTTCGGCCCTGGCGGCGCGCGCTCGCCTAGC
GGGCGGGCACTCGCGCGCAGCGTTTGTGTTGCCTGCGAGTTTCCCGAGTTCACACAGGCCCTGGGTTGGCATGGCAACCAGGCAACCTGT
TCCAGAGCCGCCAGCCTTCTCCGCACATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGT
CCCCAGTGGGCCGCCATGTTGTCGGAGTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGG
ACTCTTTCAGCCCCCACCTGAAACATCACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAG
CGCAGCCACAACCAGCTGCAAATCAGGCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCC
AGGACGACGCTATGGTGGACTACTTCTTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATA
GCAAACATCGATGGCCTACTGGGGATAACATTCATGCAGAACATCAGGTGCGTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTG
CTCTGGAGGGAAGAGCGATGGGAGAGCAGCTCTTGCCAGGTAAAAAGTTTTGGGAAACAGATGAATCCAGCAAAGATGGACCAAAAGGAA
TATTCCTGGGTGATCAATGGCGAGACAGTGCCTGGGGAACATCAGATCATTCAGTTTCCCAGCCAATCATGGTGCAGAGAAGACCTGGTC
AGAGTTTCCATGTGAACAGTGAGGTCAATTCTGTACTGTCCCCACGATCGGAGAGTGGGGGACTAGGCGTTAGCATGGTGGAGTATGTGT
TGAGCTCATCCCCGGGCGATTCCTGTCTAAGAAAAGGAGGATTTGGCCCAAGGGATGCAGACAGTGATGAAAACGACAAAGGTGAAAAGA
AGAACAAGGGTACGTTTGATGGAGATAAGCTAGGAGATTTGAAGGAGGAGGGTGATGTGATGGACAAGACCAATGGTTTACCAGTGCAGA
ATGGGATTGATGCAGACGTCAAAGATTTTAGCCGTACCCCTGGTAATTGCCAGAACTCTGCTAATGAAGTGGATCTTCTGGGTCCAAACC
AGAATGGTTCTGAGGGCTTAGCCCAGCTGACCAGCACCAATGGTGCCAAGCCTGTGGAGGATTTCTCCAACATGGAGTCCCAGAGTGTCC
CCTTGGACCCCATGGAACATGTGGGCATGGAGCCTCTTCAGTTTGATTATTCAGGCACGCAGGTACCTGTGGACTCAGCAGCAGCAACTG
TGGGACTTTTTGACTACAATTCTCAACAACAGCTGTTCCAAAGACCTAATGCGCTTGCTGTCCAGCAGTTGACAGCTGCTCAGCAGCAGC
AGTATGCACTGGCAGCTGCTCATCAGCCGCACATCGGTTTAGCTCCCGCTGCGTTTGTCCCCAATCCATACATCATCAGCGCTGCTCCCC
CAGGGACGGACCCCTACACAGCTGGATTGGCTGCAGCAGCGACACTAGGCCCAGCTGTGGTCCCTCACCAGTATTATGGAGTTACTCCCT
GGGGAGTCTACCCTGCCAGTCTTTTCCAGCAGCAAGCTGCCGCTGCCGCTGCAGCAACTAATTCAGCTAATCAACAGACCACCCCACAGG
CTCAGCAAGGACAGCAGCAGGTTCTCCGTGGAGGAGCCAGCCAACGTCCTTTGACCCCAAACCAGAACCAGCAGGGACAGCAAACGGATC
CCCTTGTGGCAGCTGCAGCAGTGAATTCTGCCCTTGCATTTGGACAAGGTCTGGCAGCAGGCATGCCAGGTTATCCGGTGTTGGCTCCTG
CTGCTTACTATGACCAAACTGGTGCCCTTGTAGTGAATGCAGGCGCGAGAAATGGTCTTGGAGCTCCTGTTCGACTTGTAGCTCCTGCCC
CAGTCATCATTAGTTCCTCAGCTGCACAAGCAGCTGTTGCAGCAGCCGCAGCTTCAGCAAATGGAGCAGCTGGTGGTCTTGCTGGAACAA
CAAATGGACCATTTCGCCCTTTAGGAACACAGCAGCCTCAGCCCCAGCCCCAGCAGCAGCCCAATAACAACCTGGCATCCAGTTCTTTCT
ACGGCAACAACTCTCTGAACAGCAATTCACAGAGCAGCTCCCTCTTCTCCCAGGGCTCTGCCCAGCCTGCCAACACATCCTTGGGATTCG
GAAGTAGCAGTTCTCTCGGCGCCACCCTGGGATCCGCCCTTGGAGGGTTTGGAACAGCAGTTGCAAACTCCAACACTGGCAGTGGCTCCC
GCCGTGACTCCCTGACTGGCAGCAGTGACCTTTATAAGAGGACATCGAGCAGCTTGACCCCCATTGGACACAGTTTTTATAACGGCCTTA
GCTTTTCCTCCTCTCCTGGACCCGTGGGCATGCCTCTCCCTAGTCAGGGACCAGGACATTCACAGACACCACCTCCTTCCCTCTCTTCAC
ATGGATCCTCTTCAAGCTTAAACCTGGGAGGACTCACGAATGGCAGTGGAAGATACATCTCTGCTGCTCCAGGCGCTGAAGCCAAGTACC
GCAGTGCAAGCAGCGCCTCCAGCCTCTTCAGCCCGAGCAGCACTCTTTTCTCTTCCTCTCGTTTGCGATATGGAATGTCTGATGTCATGC
CTTCTGGCAGGAGCAGGCTTTTGGAAGATTTTCGAAACAACCGGTACCCCAATTTACAACTGCGGGAGATTGCTGGACATATAATGGAAT
TTTCCCAAGACCAGCATGGGTCCAGATTCATTCAGCTGAAACTGGAGCGTGCCACACCAGCTGAGCGCCAGCTTGTCTTCAATGAAATCC
TCCAGGCTGCCTACCAACTCATGGTGGATGTGTTTGGTAATTACGTCATTCAGAAGTTCTTTGAAATCCGGCGCAGGAGACCAACGCCTG
CCATGCTGTTCCGGCTCTCAGAGCACTCCTCACCAGAGGAGGAAGCCTCCCCCCACCAGAGAGCCTCAGGAGAGGGGCACCATCTCAAGT
CGAAGAGACCCAACCCCTGTGCCTACACACCACCTTCGCTGAAAGCTGTGCAGCGCATTGCTGAGTCTCACCTGCAGTCTATCAGCAATT
TGAATGAGAACCAGGCCTCAGAGGAGGAGGATGAGCTGGGGGAGCTTCGGGAGCTGGGTTATCCAAGAGAGGAAGATGAGGAGGAAGAGG
AGGATGATGAAGAAGAGGAAGAAGAAGAGGACAGCCAGGCTGAAGTCCTGAAGGTCATCAGGCAGTCTGCTGGGCAAAAGACAACCTGTG
GCCAGGGTCTGGAAGGGCCCTGGGAGCGCCCACCCCCTCTGGATGAGTCCGAGAGAGATGGAGGCTCTGAGGACCAAGTGGAAGACCCAG
CACTAAGTGAGCCTGGGGAGGAACCTCAGCGCCCTTCCCCCTCTGAGCCTGGCACATAGGCACCCAGCCTGCATCTCCCAGGAGGAAGTG
GAGGGGACATCGCTGTTCCCCAGAAACCCACTCTATCCTCACCCTGTTTTGTGCTCTTCCCCTCGCCTGCTAGGGCTGCGGCTTCTGACT

>In-frame_ENST00000373741_ENST00000580825_TCGA-R6-A8W5_PUM1_chr1_31425080_-_PPP1R1B_chr17_37785422_length(amino acids)=1151AA_start in transcript=113_stop in transcript=3568
MCCLRVSRVHTGPGLAWQPGNLFQSRQPSPHMPLPPPGPGPEPIPGCTAPTQSPVGRHVVGVKGVGGMSVACVLKRKAVLWQDSFSPHLK
HHPQEPANPNMPVVLTSGTGSQAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTG
DNIHAEHQVRSMDELNHDFQALALEGRAMGEQLLPGKKFWETDESSKDGPKGIFLGDQWRDSAWGTSDHSVSQPIMVQRRPGQSFHVNSE
VNSVLSPRSESGGLGVSMVEYVLSSSPGDSCLRKGGFGPRDADSDENDKGEKKNKGTFDGDKLGDLKEEGDVMDKTNGLPVQNGIDADVK
DFSRTPGNCQNSANEVDLLGPNQNGSEGLAQLTSTNGAKPVEDFSNMESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSAAATVGLFDYNS
QQQLFQRPNALAVQQLTAAQQQQYALAAAHQPHIGLAPAAFVPNPYIISAAPPGTDPYTAGLAAAATLGPAVVPHQYYGVTPWGVYPASL
FQQQAAAAAAATNSANQQTTPQAQQGQQQVLRGGASQRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAAGMPGYPVLAPAAYYDQTG
ALVVNAGARNGLGAPVRLVAPAPVIISSSAAQAAVAAAAASANGAAGGLAGTTNGPFRPLGTQQPQPQPQQQPNNNLASSSFYGNNSLNS
NSQSSSLFSQGSAQPANTSLGFGSSSSLGATLGSALGGFGTAVANSNTGSGSRRDSLTGSSDLYKRTSSSLTPIGHSFYNGLSFSSSPGP
VGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGLTNGSGRYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLL
EDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEIRRRRPTPAMLFRLSE
HSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPREEDEEEEEDDEEEEE

--------------------------------------------------------------
>In-frame_ENST00000373741_ENST00000254079_TCGA-R6-A8W5_PUM1_chr1_31425080_-_PPP1R1B_chr17_37785422_length(transcript)=4330nt_BP=3035nt
AACCCCGCGTGCCCAGCTCCAGGCCGTGTTCTCCCAGGTGCGGGCCGGCGGGACCCCGCCTTCGGCCCTGGCGGCGCGCGCTCGCCTAGC
GGGCGGGCACTCGCGCGCAGCGTTTGTGTTGCCTGCGAGTTTCCCGAGTTCACACAGGCCCTGGGTTGGCATGGCAACCAGGCAACCTGT
TCCAGAGCCGCCAGCCTTCTCCGCACATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGT
CCCCAGTGGGCCGCCATGTTGTCGGAGTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGG
ACTCTTTCAGCCCCCACCTGAAACATCACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAG
CGCAGCCACAACCAGCTGCAAATCAGGCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCC
AGGACGACGCTATGGTGGACTACTTCTTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATA
GCAAACATCGATGGCCTACTGGGGATAACATTCATGCAGAACATCAGGTGCGTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTG
CTCTGGAGGGAAGAGCGATGGGAGAGCAGCTCTTGCCAGGTAAAAAGTTTTGGGAAACAGATGAATCCAGCAAAGATGGACCAAAAGGAA
TATTCCTGGGTGATCAATGGCGAGACAGTGCCTGGGGAACATCAGATCATTCAGTTTCCCAGCCAATCATGGTGCAGAGAAGACCTGGTC
AGAGTTTCCATGTGAACAGTGAGGTCAATTCTGTACTGTCCCCACGATCGGAGAGTGGGGGACTAGGCGTTAGCATGGTGGAGTATGTGT
TGAGCTCATCCCCGGGCGATTCCTGTCTAAGAAAAGGAGGATTTGGCCCAAGGGATGCAGACAGTGATGAAAACGACAAAGGTGAAAAGA
AGAACAAGGGTACGTTTGATGGAGATAAGCTAGGAGATTTGAAGGAGGAGGGTGATGTGATGGACAAGACCAATGGTTTACCAGTGCAGA
ATGGGATTGATGCAGACGTCAAAGATTTTAGCCGTACCCCTGGTAATTGCCAGAACTCTGCTAATGAAGTGGATCTTCTGGGTCCAAACC
AGAATGGTTCTGAGGGCTTAGCCCAGCTGACCAGCACCAATGGTGCCAAGCCTGTGGAGGATTTCTCCAACATGGAGTCCCAGAGTGTCC
CCTTGGACCCCATGGAACATGTGGGCATGGAGCCTCTTCAGTTTGATTATTCAGGCACGCAGGTACCTGTGGACTCAGCAGCAGCAACTG
TGGGACTTTTTGACTACAATTCTCAACAACAGCTGTTCCAAAGACCTAATGCGCTTGCTGTCCAGCAGTTGACAGCTGCTCAGCAGCAGC
AGTATGCACTGGCAGCTGCTCATCAGCCGCACATCGGTTTAGCTCCCGCTGCGTTTGTCCCCAATCCATACATCATCAGCGCTGCTCCCC
CAGGGACGGACCCCTACACAGCTGGATTGGCTGCAGCAGCGACACTAGGCCCAGCTGTGGTCCCTCACCAGTATTATGGAGTTACTCCCT
GGGGAGTCTACCCTGCCAGTCTTTTCCAGCAGCAAGCTGCCGCTGCCGCTGCAGCAACTAATTCAGCTAATCAACAGACCACCCCACAGG
CTCAGCAAGGACAGCAGCAGGTTCTCCGTGGAGGAGCCAGCCAACGTCCTTTGACCCCAAACCAGAACCAGCAGGGACAGCAAACGGATC
CCCTTGTGGCAGCTGCAGCAGTGAATTCTGCCCTTGCATTTGGACAAGGTCTGGCAGCAGGCATGCCAGGTTATCCGGTGTTGGCTCCTG
CTGCTTACTATGACCAAACTGGTGCCCTTGTAGTGAATGCAGGCGCGAGAAATGGTCTTGGAGCTCCTGTTCGACTTGTAGCTCCTGCCC
CAGTCATCATTAGTTCCTCAGCTGCACAAGCAGCTGTTGCAGCAGCCGCAGCTTCAGCAAATGGAGCAGCTGGTGGTCTTGCTGGAACAA
CAAATGGACCATTTCGCCCTTTAGGAACACAGCAGCCTCAGCCCCAGCCCCAGCAGCAGCCCAATAACAACCTGGCATCCAGTTCTTTCT
ACGGCAACAACTCTCTGAACAGCAATTCACAGAGCAGCTCCCTCTTCTCCCAGGGCTCTGCCCAGCCTGCCAACACATCCTTGGGATTCG
GAAGTAGCAGTTCTCTCGGCGCCACCCTGGGATCCGCCCTTGGAGGGTTTGGAACAGCAGTTGCAAACTCCAACACTGGCAGTGGCTCCC
GCCGTGACTCCCTGACTGGCAGCAGTGACCTTTATAAGAGGACATCGAGCAGCTTGACCCCCATTGGACACAGTTTTTATAACGGCCTTA
GCTTTTCCTCCTCTCCTGGACCCGTGGGCATGCCTCTCCCTAGTCAGGGACCAGGACATTCACAGACACCACCTCCTTCCCTCTCTTCAC
ATGGATCCTCTTCAAGCTTAAACCTGGGAGGACTCACGAATGGCAGTGGAAGATACATCTCTGCTGCTCCAGGCGCTGAAGCCAAGTACC
GCAGTGCAAGCAGCGCCTCCAGCCTCTTCAGCCCGAGCAGCACTCTTTTCTCTTCCTCTCGTTTGCGATATGGAATGTCTGATGTCATGC
CTTCTGGCAGGAGCAGGCTTTTGGAAGATTTTCGAAACAACCGGTACCCCAATTTACAACTGCGGGAGATTGCTGGACATATAATGGAAT
TTTCCCAAGACCAGCATGGGTCCAGATTCATTCAGCTGAAACTGGAGCGTGCCACACCAGCTGAGCGCCAGCTTGTCTTCAATGAAATCC
TCCAGGCTGCCTACCAACTCATGGTGGATGTGTTTGGTAATTACGTCATTCAGAAGTTCTTTGAAATCCGGCGCAGGAGACCAACGCCTG
CCATGCTGTTCCGGCTCTCAGAGCACTCCTCACCAGAGGAGGAAGCCTCCCCCCACCAGAGAGCCTCAGGAGAGGGGCACCATCTCAAGT
CGAAGAGACCCAACCCCTGTGCCTACACACCACCTTCGCTGAAAGCTGTGCAGCGCATTGCTGAGTCTCACCTGCAGTCTATCAGCAATT
TGAATGAGAACCAGGCCTCAGAGGAGGAGGATGAGCTGGGGGAGCTTCGGGAGCTGGGTTATCCAAGAGAGGAAGATGAGGAGGAAGAGG
AGGATGATGAAGAAGAGGAAGAAGAAGAGGACAGCCAGGCTGAAGTCCTGAAGGTCATCAGGCAGTCTGCTGGGCAAAAGACAACCTGTG
GCCAGGGTCTGGAAGGGCCCTGGGAGCGCCCACCCCCTCTGGATGAGTCCGAGAGAGATGGAGGCTCTGAGGACCAAGTGGAAGACCCAG
CACTAAGTGAGCCTGGGGAGGAACCTCAGCGCCCTTCCCCCTCTGAGCCTGGCACATAGGCACCCAGCCTGCATCTCCCAGGAGGAAGTG
GAGGGGACATCGCTGTTCCCCAGAAACCCACTCTATCCTCACCCTGTTTTGTGCTCTTCCCCTCGCCTGCTAGGGCTGCGGCTTCTGACT
TCTAGAAGACTAAGGCTGGTCTGTGTTTGCTTGTTTGCCCACCTTTGGCTGATACCCAGAGAACCTGGGCACTTGCTGCCTGATGCCCAC
CCCTGCCAGTCATTCCTCCATTCACCCAGCGGGAGGTGGGATGTGAGACAGCCCACATTGGAAAATCCAGAAAACCGGGAACAGGGATTT
GCCCTTCACAATTCTACTCCCCAGATCCTCTCCCCTGGACACAGGAGACCCACAGGGCAGGACCCTAAGATCTGGGGAAAGGAGGTCCTG
AGAACCTTGAGGTACCCTTAGATCCTTTTCTACCCACTTTCCTATGGAGGATTCCAAGTCACCACTTCTCTCACCGGCTTCTACCAGGGT
CCAGGACTAAGGCGTTTTTCTCCATAGCCTCAACATTTTGGGAATCTTCCCTTAATCACCCTTGCTCCTCCTGGGTGCCTGGAAGATGGA
CTGGCAGAGACCTCTTTGTTGCGTTTTGTGCTTTGATGCCAGGAATGCCGCCTAGTTTATGTCCCCGGTGGGGCACACAGCGGGGGGCGC
CAGGTTTTCCTTGTCCCCCAGCTGCTCTGCCCCTTTCCCCTTCTTCCCTGACTCCAGGCCTGAACCCCTCCCGTGCTGTAATAAATCTTT

>In-frame_ENST00000373741_ENST00000254079_TCGA-R6-A8W5_PUM1_chr1_31425080_-_PPP1R1B_chr17_37785422_length(amino acids)=1151AA_start in transcript=113_stop in transcript=3568
MCCLRVSRVHTGPGLAWQPGNLFQSRQPSPHMPLPPPGPGPEPIPGCTAPTQSPVGRHVVGVKGVGGMSVACVLKRKAVLWQDSFSPHLK
HHPQEPANPNMPVVLTSGTGSQAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTG
DNIHAEHQVRSMDELNHDFQALALEGRAMGEQLLPGKKFWETDESSKDGPKGIFLGDQWRDSAWGTSDHSVSQPIMVQRRPGQSFHVNSE
VNSVLSPRSESGGLGVSMVEYVLSSSPGDSCLRKGGFGPRDADSDENDKGEKKNKGTFDGDKLGDLKEEGDVMDKTNGLPVQNGIDADVK
DFSRTPGNCQNSANEVDLLGPNQNGSEGLAQLTSTNGAKPVEDFSNMESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSAAATVGLFDYNS
QQQLFQRPNALAVQQLTAAQQQQYALAAAHQPHIGLAPAAFVPNPYIISAAPPGTDPYTAGLAAAATLGPAVVPHQYYGVTPWGVYPASL
FQQQAAAAAAATNSANQQTTPQAQQGQQQVLRGGASQRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAAGMPGYPVLAPAAYYDQTG
ALVVNAGARNGLGAPVRLVAPAPVIISSSAAQAAVAAAAASANGAAGGLAGTTNGPFRPLGTQQPQPQPQQQPNNNLASSSFYGNNSLNS
NSQSSSLFSQGSAQPANTSLGFGSSSSLGATLGSALGGFGTAVANSNTGSGSRRDSLTGSSDLYKRTSSSLTPIGHSFYNGLSFSSSPGP
VGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGLTNGSGRYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLL
EDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEIRRRRPTPAMLFRLSE
HSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPREEDEEEEEDDEEEEE

--------------------------------------------------------------
>In-frame_ENST00000373741_ENST00000579000_TCGA-R6-A8W5_PUM1_chr1_31425080_-_PPP1R1B_chr17_37785422_length(transcript)=4227nt_BP=3035nt
AACCCCGCGTGCCCAGCTCCAGGCCGTGTTCTCCCAGGTGCGGGCCGGCGGGACCCCGCCTTCGGCCCTGGCGGCGCGCGCTCGCCTAGC
GGGCGGGCACTCGCGCGCAGCGTTTGTGTTGCCTGCGAGTTTCCCGAGTTCACACAGGCCCTGGGTTGGCATGGCAACCAGGCAACCTGT
TCCAGAGCCGCCAGCCTTCTCCGCACATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGT
CCCCAGTGGGCCGCCATGTTGTCGGAGTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGG
ACTCTTTCAGCCCCCACCTGAAACATCACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAG
CGCAGCCACAACCAGCTGCAAATCAGGCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCC
AGGACGACGCTATGGTGGACTACTTCTTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATA
GCAAACATCGATGGCCTACTGGGGATAACATTCATGCAGAACATCAGGTGCGTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTG
CTCTGGAGGGAAGAGCGATGGGAGAGCAGCTCTTGCCAGGTAAAAAGTTTTGGGAAACAGATGAATCCAGCAAAGATGGACCAAAAGGAA
TATTCCTGGGTGATCAATGGCGAGACAGTGCCTGGGGAACATCAGATCATTCAGTTTCCCAGCCAATCATGGTGCAGAGAAGACCTGGTC
AGAGTTTCCATGTGAACAGTGAGGTCAATTCTGTACTGTCCCCACGATCGGAGAGTGGGGGACTAGGCGTTAGCATGGTGGAGTATGTGT
TGAGCTCATCCCCGGGCGATTCCTGTCTAAGAAAAGGAGGATTTGGCCCAAGGGATGCAGACAGTGATGAAAACGACAAAGGTGAAAAGA
AGAACAAGGGTACGTTTGATGGAGATAAGCTAGGAGATTTGAAGGAGGAGGGTGATGTGATGGACAAGACCAATGGTTTACCAGTGCAGA
ATGGGATTGATGCAGACGTCAAAGATTTTAGCCGTACCCCTGGTAATTGCCAGAACTCTGCTAATGAAGTGGATCTTCTGGGTCCAAACC
AGAATGGTTCTGAGGGCTTAGCCCAGCTGACCAGCACCAATGGTGCCAAGCCTGTGGAGGATTTCTCCAACATGGAGTCCCAGAGTGTCC
CCTTGGACCCCATGGAACATGTGGGCATGGAGCCTCTTCAGTTTGATTATTCAGGCACGCAGGTACCTGTGGACTCAGCAGCAGCAACTG
TGGGACTTTTTGACTACAATTCTCAACAACAGCTGTTCCAAAGACCTAATGCGCTTGCTGTCCAGCAGTTGACAGCTGCTCAGCAGCAGC
AGTATGCACTGGCAGCTGCTCATCAGCCGCACATCGGTTTAGCTCCCGCTGCGTTTGTCCCCAATCCATACATCATCAGCGCTGCTCCCC
CAGGGACGGACCCCTACACAGCTGGATTGGCTGCAGCAGCGACACTAGGCCCAGCTGTGGTCCCTCACCAGTATTATGGAGTTACTCCCT
GGGGAGTCTACCCTGCCAGTCTTTTCCAGCAGCAAGCTGCCGCTGCCGCTGCAGCAACTAATTCAGCTAATCAACAGACCACCCCACAGG
CTCAGCAAGGACAGCAGCAGGTTCTCCGTGGAGGAGCCAGCCAACGTCCTTTGACCCCAAACCAGAACCAGCAGGGACAGCAAACGGATC
CCCTTGTGGCAGCTGCAGCAGTGAATTCTGCCCTTGCATTTGGACAAGGTCTGGCAGCAGGCATGCCAGGTTATCCGGTGTTGGCTCCTG
CTGCTTACTATGACCAAACTGGTGCCCTTGTAGTGAATGCAGGCGCGAGAAATGGTCTTGGAGCTCCTGTTCGACTTGTAGCTCCTGCCC
CAGTCATCATTAGTTCCTCAGCTGCACAAGCAGCTGTTGCAGCAGCCGCAGCTTCAGCAAATGGAGCAGCTGGTGGTCTTGCTGGAACAA
CAAATGGACCATTTCGCCCTTTAGGAACACAGCAGCCTCAGCCCCAGCCCCAGCAGCAGCCCAATAACAACCTGGCATCCAGTTCTTTCT
ACGGCAACAACTCTCTGAACAGCAATTCACAGAGCAGCTCCCTCTTCTCCCAGGGCTCTGCCCAGCCTGCCAACACATCCTTGGGATTCG
GAAGTAGCAGTTCTCTCGGCGCCACCCTGGGATCCGCCCTTGGAGGGTTTGGAACAGCAGTTGCAAACTCCAACACTGGCAGTGGCTCCC
GCCGTGACTCCCTGACTGGCAGCAGTGACCTTTATAAGAGGACATCGAGCAGCTTGACCCCCATTGGACACAGTTTTTATAACGGCCTTA
GCTTTTCCTCCTCTCCTGGACCCGTGGGCATGCCTCTCCCTAGTCAGGGACCAGGACATTCACAGACACCACCTCCTTCCCTCTCTTCAC
ATGGATCCTCTTCAAGCTTAAACCTGGGAGGACTCACGAATGGCAGTGGAAGATACATCTCTGCTGCTCCAGGCGCTGAAGCCAAGTACC
GCAGTGCAAGCAGCGCCTCCAGCCTCTTCAGCCCGAGCAGCACTCTTTTCTCTTCCTCTCGTTTGCGATATGGAATGTCTGATGTCATGC
CTTCTGGCAGGAGCAGGCTTTTGGAAGATTTTCGAAACAACCGGTACCCCAATTTACAACTGCGGGAGATTGCTGGACATATAATGGAAT
TTTCCCAAGACCAGCATGGGTCCAGATTCATTCAGCTGAAACTGGAGCGTGCCACACCAGCTGAGCGCCAGCTTGTCTTCAATGAAATCC
TCCAGGCTGCCTACCAACTCATGGTGGATGTGTTTGGTAATTACGTCATTCAGAAGTTCTTTGAAATCCGGCGCAGGAGACCAACGCCTG
CCATGCTGTTCCGGCTCTCAGAGCACTCCTCACCAGCTGTGCAGCGCATTGCTGAGTCTCACCTGCAGTCTATCAGCAATTTGAATGAGA
ACCAGGCCTCAGAGGAGGAGGATGAGCTGGGGGAGCTTCGGGAGCTGGGTTATCCAAGAGAGGAAGATGAGGAGGAAGAGGAGGATGATG
AAGAAGAGGAAGAAGAAGAGGACAGCCAGGCTGAAGTCCTGAAGGTCATCAGGCAGTCTGCTGGGCAAAAGACAACCTGTGGCCAGGGTC
TGGAAGGGCCCTGGGAGCGCCCACCCCCTCTGGATGAGTCCGAGAGAGATGGAGGCTCTGAGGACCAAGTGGAAGACCCAGCACTAAGTG
AGCCTGGGGAGGAACCTCAGCGCCCTTCCCCCTCTGAGCCTGGCACATAGGCACCCAGCCTGCATCTCCCAGGAGGAAGTGGAGGGGACA
TCGCTGTTCCCCAGAAACCCACTCTATCCTCACCCTGTTTTGTGCTCTTCCCCTCGCCTGCTAGGGCTGCGGCTTCTGACTTCTAGAAGA
CTAAGGCTGGTCTGTGTTTGCTTGTTTGCCCACCTTTGGCTGATACCCAGAGAACCTGGGCACTTGCTGCCTGATGCCCACCCCTGCCAG
TCATTCCTCCATTCACCCAGCGGGAGGTGGGATGTGAGACAGCCCACATTGGAAAATCCAGAAAACCGGGAACAGGGATTTGCCCTTCAC
AATTCTACTCCCCAGATCCTCTCCCCTGGACACAGGAGACCCACAGGGCAGGACCCTAAGATCTGGGGAAAGGAGGTCCTGAGAACCTTG
AGGTACCCTTAGATCCTTTTCTACCCACTTTCCTATGGAGGATTCCAAGTCACCACTTCTCTCACCGGCTTCTACCAGGGTCCAGGACTA
AGGCGTTTTTCTCCATAGCCTCAACATTTTGGGAATCTTCCCTTAATCACCCTTGCTCCTCCTGGGTGCCTGGAAGATGGACTGGCAGAG
ACCTCTTTGTTGCGTTTTGTGCTTTGATGCCAGGAATGCCGCCTAGTTTATGTCCCCGGTGGGGCACACAGCGGGGGGCGCCAGGTTTTC

>In-frame_ENST00000373741_ENST00000579000_TCGA-R6-A8W5_PUM1_chr1_31425080_-_PPP1R1B_chr17_37785422_length(amino acids)=1118AA_start in transcript=113_stop in transcript=3469
MCCLRVSRVHTGPGLAWQPGNLFQSRQPSPHMPLPPPGPGPEPIPGCTAPTQSPVGRHVVGVKGVGGMSVACVLKRKAVLWQDSFSPHLK
HHPQEPANPNMPVVLTSGTGSQAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTG
DNIHAEHQVRSMDELNHDFQALALEGRAMGEQLLPGKKFWETDESSKDGPKGIFLGDQWRDSAWGTSDHSVSQPIMVQRRPGQSFHVNSE
VNSVLSPRSESGGLGVSMVEYVLSSSPGDSCLRKGGFGPRDADSDENDKGEKKNKGTFDGDKLGDLKEEGDVMDKTNGLPVQNGIDADVK
DFSRTPGNCQNSANEVDLLGPNQNGSEGLAQLTSTNGAKPVEDFSNMESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSAAATVGLFDYNS
QQQLFQRPNALAVQQLTAAQQQQYALAAAHQPHIGLAPAAFVPNPYIISAAPPGTDPYTAGLAAAATLGPAVVPHQYYGVTPWGVYPASL
FQQQAAAAAAATNSANQQTTPQAQQGQQQVLRGGASQRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAAGMPGYPVLAPAAYYDQTG
ALVVNAGARNGLGAPVRLVAPAPVIISSSAAQAAVAAAAASANGAAGGLAGTTNGPFRPLGTQQPQPQPQQQPNNNLASSSFYGNNSLNS
NSQSSSLFSQGSAQPANTSLGFGSSSSLGATLGSALGGFGTAVANSNTGSGSRRDSLTGSSDLYKRTSSSLTPIGHSFYNGLSFSSSPGP
VGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGLTNGSGRYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLL
EDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEIRRRRPTPAMLFRLSE
HSSPAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSAGQKTTCGQGLEGPWERP

--------------------------------------------------------------
>In-frame_ENST00000373742_ENST00000580825_TCGA-R6-A8W5_PUM1_chr1_31425080_-_PPP1R1B_chr17_37785422_length(transcript)=3213nt_BP=2544nt
ATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGTCCCCAGTGGGCCGCCATGTTGTCGGA
GTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGGACTCTTTCAGCCCCCACCTGAAACAT
CACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAGCGCAGCCACAACCAGCTGCAAATCAG
GCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCCAGGACGACGCTATGGTGGACTACTTC
TTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATAGCAAACATCGATGGCCTACTGGGGAT
AACATTCATGCAGAACATCAGGTGCGTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTGCTCTGGAGGGAAGAGCGATGGGAGAG
GGCCCAAGGGATGCAGACAGTGATGAAAACGACAAAGGTGAAAAGAAGAACAAGGGTACGTTTGATGGAGATAAGCTAGGAGATTTGAAG
GAGGAGGGTGATGTGATGGACAAGACCAATGGTTTACCAGTGCAGAATGGGATTGATGCAGACGTCAAAGATTTTAGCCGTACCCCTGGT
AATTGCCAGAACTCTGCTAATGAAGTGGATCTTCTGGGTCCAAACCAGAATGGTTCTGAGGGCTTAGCCCAGCTGACCAGCACCAATGGT
GCCAAGCCTGTGGAGGATTTCTCCAACATGGAGTCCCAGAGTGTCCCCTTGGACCCCATGGAACATGTGGGCATGGAGCCTCTTCAGTTT
GATTATTCAGGCACGCAGGTACCTGTGGACTCAGCAGCAGCAACTGTGGGACTTTTTGACTACAATTCTCAACAACAGCTGTTCCAAAGA
CCTAATGCGCTTGCTGTCCAGCAGTTGACAGCTGCTCAGCAGCAGCAGTATGCACTGGCAGCTGCTCATCAGCCGCACATCGCAGGTTTA
GCTCCCGCTGCGTTTGTCCCCAATCCATACATCATCAGCGCTGCTCCCCCAGGGACGGACCCCTACACAGCTGGATTGGCTGCAGCAGCG
ACACTAGGCCCAGCTGTGGTCCCTCACCAGTATTATGGAGTTACTCCCTGGGGAGTCTACCCTGCCAGTCTTTTCCAGCAGCAAGCTGCC
GCTGCCGCTGCAGCAACTAATTCAGCTAATCAACAGACCACCCCACAGGCTCAGCAAGGACAGCAGCAGGTTCTCCGTGGAGGAGCCAGC
CAACGTCCTTTGACCCCAAACCAGAACCAGCAGGGACAGCAAACGGATCCCCTTGTGGCAGCTGCAGCAGTGAATTCTGCCCTTGCATTT
GGACAAGGTCTGGCAGCAGGCATGCCAGGTTATCCGGTGTTGGCTCCTGCTGCTTACTATGACCAAACTGGTGCCCTTGTAGTGAATGCA
GGCGCGAGAAATGGTCTTGGAGCTCCTGTTCGACTTGTAGCTCCTGCCCCAGTCATCATTAGTTCCTCAGCTGCACAAGCAGCTGTTGCA
GCAGCCGCAGCTTCAGCAAATGGAGCAGCTGGTGGTCTTGCTGGAACAACAAATGGACCATTTCGCCCTTTAGGAACACAGCAGCCTCAG
CCCCAGCCCCAGCAGCAGCCCAATAACAACCTGGCATCCAGTTCTTTCTACGGCAACAACTCTCTGAACAGCAATTCACAGAGCAGCTCC
CTCTTCTCCCAGGGCTCTGCCCAGCCTGCCAACACATCCTTGGGATTCGGAAGTAGCAGTTCTCTCGGCGCCACCCTGGGATCCGCCCTT
GGAGGGTTTGGAACAGCAGTTGCAAACTCCAACACTGGCAGTGGCTCCCGCCGTGACTCCCTGACTGGCAGCAGTGACCTTTATAAGAGG
ACATCGAGCAGCTTGACCCCCATTGGACACAGTTTTTATAACGGCCTTAGCTTTTCCTCCTCTCCTGGACCCGTGGGCATGCCTCTCCCT
AGTCAGGGACCAGGACATTCACAGACACCACCTCCTTCCCTCTCTTCACATGGATCCTCTTCAAGCTTAAACCTGGGAGGACTCACGAAT
GGCAGTGGAAGATACATCTCTGCTGCTCCAGGCGCTGAAGCCAAGTACCGCAGTGCAAGCAGCGCCTCCAGCCTCTTCAGCCCGAGCAGC
ACTCTTTTCTCTTCCTCTCGTTTGCGATATGGAATGTCTGATGTCATGCCTTCTGGCAGGAGCAGGCTTTTGGAAGATTTTCGAAACAAC
CGGTACCCCAATTTACAACTGCGGGAGATTGCTGGACATATAATGGAATTTTCCCAAGACCAGCATGGGTCCAGATTCATTCAGCTGAAA
CTGGAGCGTGCCACACCAGCTGAGCGCCAGCTTGTCTTCAATGAAATCCTCCAGGCTGCCTACCAACTCATGGTGGATGTGTTTGGTAAT
TACGTCATTCAGAAGTTCTTTGAAATCCGGCGCAGGAGACCAACGCCTGCCATGCTGTTCCGGCTCTCAGAGCACTCCTCACCAGAGGAG
GAAGCCTCCCCCCACCAGAGAGCCTCAGGAGAGGGGCACCATCTCAAGTCGAAGAGACCCAACCCCTGTGCCTACACACCACCTTCGCTG
AAAGCTGTGCAGCGCATTGCTGAGTCTCACCTGCAGTCTATCAGCAATTTGAATGAGAACCAGGCCTCAGAGGAGGAGGATGAGCTGGGG
GAGCTTCGGGAGCTGGGTTATCCAAGAGAGGAAGATGAGGAGGAAGAGGAGGATGATGAAGAAGAGGAAGAAGAAGAGGACAGCCAGGCT
GAAGTCCTGAAGGTCATCAGGCAGTCTGCTGGGCAAAAGACAACCTGTGGCCAGGGTCTGGAAGGGCCCTGGGAGCGCCCACCCCCTCTG
GATGAGTCCGAGAGAGATGGAGGCTCTGAGGACCAAGTGGAAGACCCAGCACTAAGTGAGCCTGGGGAGGAACCTCAGCGCCCTTCCCCC
TCTGAGCCTGGCACATAGGCACCCAGCCTGCATCTCCCAGGAGGAAGTGGAGGGGACATCGCTGTTCCCCAGAAACCCACTCTATCCTCA

>In-frame_ENST00000373742_ENST00000580825_TCGA-R6-A8W5_PUM1_chr1_31425080_-_PPP1R1B_chr17_37785422_length(amino acids)=1025AA_start in transcript=0_stop in transcript=3077
MPLPPPGPGPEPIPGCTAPTQSPVGRHVVGVKGVGGMSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGSQAQPQPAANQ
ALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGE
GPRDADSDENDKGEKKNKGTFDGDKLGDLKEEGDVMDKTNGLPVQNGIDADVKDFSRTPGNCQNSANEVDLLGPNQNGSEGLAQLTSTNG
AKPVEDFSNMESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSAAATVGLFDYNSQQQLFQRPNALAVQQLTAAQQQQYALAAAHQPHIAGL
APAAFVPNPYIISAAPPGTDPYTAGLAAAATLGPAVVPHQYYGVTPWGVYPASLFQQQAAAAAAATNSANQQTTPQAQQGQQQVLRGGAS
QRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAAGMPGYPVLAPAAYYDQTGALVVNAGARNGLGAPVRLVAPAPVIISSSAAQAAVA
AAAASANGAAGGLAGTTNGPFRPLGTQQPQPQPQQQPNNNLASSSFYGNNSLNSNSQSSSLFSQGSAQPANTSLGFGSSSSLGATLGSAL
GGFGTAVANSNTGSGSRRDSLTGSSDLYKRTSSSLTPIGHSFYNGLSFSSSPGPVGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGLTN
GSGRYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLK
LERATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSL
KAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSAGQKTTCGQGLEGPWERPPPL

--------------------------------------------------------------
>In-frame_ENST00000373742_ENST00000254079_TCGA-R6-A8W5_PUM1_chr1_31425080_-_PPP1R1B_chr17_37785422_length(transcript)=3839nt_BP=2544nt
ATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGTCCCCAGTGGGCCGCCATGTTGTCGGA
GTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGGACTCTTTCAGCCCCCACCTGAAACAT
CACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAGCGCAGCCACAACCAGCTGCAAATCAG
GCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCCAGGACGACGCTATGGTGGACTACTTC
TTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATAGCAAACATCGATGGCCTACTGGGGAT
AACATTCATGCAGAACATCAGGTGCGTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTGCTCTGGAGGGAAGAGCGATGGGAGAG
GGCCCAAGGGATGCAGACAGTGATGAAAACGACAAAGGTGAAAAGAAGAACAAGGGTACGTTTGATGGAGATAAGCTAGGAGATTTGAAG
GAGGAGGGTGATGTGATGGACAAGACCAATGGTTTACCAGTGCAGAATGGGATTGATGCAGACGTCAAAGATTTTAGCCGTACCCCTGGT
AATTGCCAGAACTCTGCTAATGAAGTGGATCTTCTGGGTCCAAACCAGAATGGTTCTGAGGGCTTAGCCCAGCTGACCAGCACCAATGGT
GCCAAGCCTGTGGAGGATTTCTCCAACATGGAGTCCCAGAGTGTCCCCTTGGACCCCATGGAACATGTGGGCATGGAGCCTCTTCAGTTT
GATTATTCAGGCACGCAGGTACCTGTGGACTCAGCAGCAGCAACTGTGGGACTTTTTGACTACAATTCTCAACAACAGCTGTTCCAAAGA
CCTAATGCGCTTGCTGTCCAGCAGTTGACAGCTGCTCAGCAGCAGCAGTATGCACTGGCAGCTGCTCATCAGCCGCACATCGCAGGTTTA
GCTCCCGCTGCGTTTGTCCCCAATCCATACATCATCAGCGCTGCTCCCCCAGGGACGGACCCCTACACAGCTGGATTGGCTGCAGCAGCG
ACACTAGGCCCAGCTGTGGTCCCTCACCAGTATTATGGAGTTACTCCCTGGGGAGTCTACCCTGCCAGTCTTTTCCAGCAGCAAGCTGCC
GCTGCCGCTGCAGCAACTAATTCAGCTAATCAACAGACCACCCCACAGGCTCAGCAAGGACAGCAGCAGGTTCTCCGTGGAGGAGCCAGC
CAACGTCCTTTGACCCCAAACCAGAACCAGCAGGGACAGCAAACGGATCCCCTTGTGGCAGCTGCAGCAGTGAATTCTGCCCTTGCATTT
GGACAAGGTCTGGCAGCAGGCATGCCAGGTTATCCGGTGTTGGCTCCTGCTGCTTACTATGACCAAACTGGTGCCCTTGTAGTGAATGCA
GGCGCGAGAAATGGTCTTGGAGCTCCTGTTCGACTTGTAGCTCCTGCCCCAGTCATCATTAGTTCCTCAGCTGCACAAGCAGCTGTTGCA
GCAGCCGCAGCTTCAGCAAATGGAGCAGCTGGTGGTCTTGCTGGAACAACAAATGGACCATTTCGCCCTTTAGGAACACAGCAGCCTCAG
CCCCAGCCCCAGCAGCAGCCCAATAACAACCTGGCATCCAGTTCTTTCTACGGCAACAACTCTCTGAACAGCAATTCACAGAGCAGCTCC
CTCTTCTCCCAGGGCTCTGCCCAGCCTGCCAACACATCCTTGGGATTCGGAAGTAGCAGTTCTCTCGGCGCCACCCTGGGATCCGCCCTT
GGAGGGTTTGGAACAGCAGTTGCAAACTCCAACACTGGCAGTGGCTCCCGCCGTGACTCCCTGACTGGCAGCAGTGACCTTTATAAGAGG
ACATCGAGCAGCTTGACCCCCATTGGACACAGTTTTTATAACGGCCTTAGCTTTTCCTCCTCTCCTGGACCCGTGGGCATGCCTCTCCCT
AGTCAGGGACCAGGACATTCACAGACACCACCTCCTTCCCTCTCTTCACATGGATCCTCTTCAAGCTTAAACCTGGGAGGACTCACGAAT
GGCAGTGGAAGATACATCTCTGCTGCTCCAGGCGCTGAAGCCAAGTACCGCAGTGCAAGCAGCGCCTCCAGCCTCTTCAGCCCGAGCAGC
ACTCTTTTCTCTTCCTCTCGTTTGCGATATGGAATGTCTGATGTCATGCCTTCTGGCAGGAGCAGGCTTTTGGAAGATTTTCGAAACAAC
CGGTACCCCAATTTACAACTGCGGGAGATTGCTGGACATATAATGGAATTTTCCCAAGACCAGCATGGGTCCAGATTCATTCAGCTGAAA
CTGGAGCGTGCCACACCAGCTGAGCGCCAGCTTGTCTTCAATGAAATCCTCCAGGCTGCCTACCAACTCATGGTGGATGTGTTTGGTAAT
TACGTCATTCAGAAGTTCTTTGAAATCCGGCGCAGGAGACCAACGCCTGCCATGCTGTTCCGGCTCTCAGAGCACTCCTCACCAGAGGAG
GAAGCCTCCCCCCACCAGAGAGCCTCAGGAGAGGGGCACCATCTCAAGTCGAAGAGACCCAACCCCTGTGCCTACACACCACCTTCGCTG
AAAGCTGTGCAGCGCATTGCTGAGTCTCACCTGCAGTCTATCAGCAATTTGAATGAGAACCAGGCCTCAGAGGAGGAGGATGAGCTGGGG
GAGCTTCGGGAGCTGGGTTATCCAAGAGAGGAAGATGAGGAGGAAGAGGAGGATGATGAAGAAGAGGAAGAAGAAGAGGACAGCCAGGCT
GAAGTCCTGAAGGTCATCAGGCAGTCTGCTGGGCAAAAGACAACCTGTGGCCAGGGTCTGGAAGGGCCCTGGGAGCGCCCACCCCCTCTG
GATGAGTCCGAGAGAGATGGAGGCTCTGAGGACCAAGTGGAAGACCCAGCACTAAGTGAGCCTGGGGAGGAACCTCAGCGCCCTTCCCCC
TCTGAGCCTGGCACATAGGCACCCAGCCTGCATCTCCCAGGAGGAAGTGGAGGGGACATCGCTGTTCCCCAGAAACCCACTCTATCCTCA
CCCTGTTTTGTGCTCTTCCCCTCGCCTGCTAGGGCTGCGGCTTCTGACTTCTAGAAGACTAAGGCTGGTCTGTGTTTGCTTGTTTGCCCA
CCTTTGGCTGATACCCAGAGAACCTGGGCACTTGCTGCCTGATGCCCACCCCTGCCAGTCATTCCTCCATTCACCCAGCGGGAGGTGGGA
TGTGAGACAGCCCACATTGGAAAATCCAGAAAACCGGGAACAGGGATTTGCCCTTCACAATTCTACTCCCCAGATCCTCTCCCCTGGACA
CAGGAGACCCACAGGGCAGGACCCTAAGATCTGGGGAAAGGAGGTCCTGAGAACCTTGAGGTACCCTTAGATCCTTTTCTACCCACTTTC
CTATGGAGGATTCCAAGTCACCACTTCTCTCACCGGCTTCTACCAGGGTCCAGGACTAAGGCGTTTTTCTCCATAGCCTCAACATTTTGG
GAATCTTCCCTTAATCACCCTTGCTCCTCCTGGGTGCCTGGAAGATGGACTGGCAGAGACCTCTTTGTTGCGTTTTGTGCTTTGATGCCA
GGAATGCCGCCTAGTTTATGTCCCCGGTGGGGCACACAGCGGGGGGCGCCAGGTTTTCCTTGTCCCCCAGCTGCTCTGCCCCTTTCCCCT

>In-frame_ENST00000373742_ENST00000254079_TCGA-R6-A8W5_PUM1_chr1_31425080_-_PPP1R1B_chr17_37785422_length(amino acids)=1025AA_start in transcript=0_stop in transcript=3077
MPLPPPGPGPEPIPGCTAPTQSPVGRHVVGVKGVGGMSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGSQAQPQPAANQ
ALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGE
GPRDADSDENDKGEKKNKGTFDGDKLGDLKEEGDVMDKTNGLPVQNGIDADVKDFSRTPGNCQNSANEVDLLGPNQNGSEGLAQLTSTNG
AKPVEDFSNMESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSAAATVGLFDYNSQQQLFQRPNALAVQQLTAAQQQQYALAAAHQPHIAGL
APAAFVPNPYIISAAPPGTDPYTAGLAAAATLGPAVVPHQYYGVTPWGVYPASLFQQQAAAAAAATNSANQQTTPQAQQGQQQVLRGGAS
QRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAAGMPGYPVLAPAAYYDQTGALVVNAGARNGLGAPVRLVAPAPVIISSSAAQAAVA
AAAASANGAAGGLAGTTNGPFRPLGTQQPQPQPQQQPNNNLASSSFYGNNSLNSNSQSSSLFSQGSAQPANTSLGFGSSSSLGATLGSAL
GGFGTAVANSNTGSGSRRDSLTGSSDLYKRTSSSLTPIGHSFYNGLSFSSSPGPVGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGLTN
GSGRYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLK
LERATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSL
KAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSAGQKTTCGQGLEGPWERPPPL

--------------------------------------------------------------
>In-frame_ENST00000373742_ENST00000579000_TCGA-R6-A8W5_PUM1_chr1_31425080_-_PPP1R1B_chr17_37785422_length(transcript)=3736nt_BP=2544nt
ATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGTCCCCAGTGGGCCGCCATGTTGTCGGA
GTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGGACTCTTTCAGCCCCCACCTGAAACAT
CACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAGCGCAGCCACAACCAGCTGCAAATCAG
GCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCCAGGACGACGCTATGGTGGACTACTTC
TTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATAGCAAACATCGATGGCCTACTGGGGAT
AACATTCATGCAGAACATCAGGTGCGTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTGCTCTGGAGGGAAGAGCGATGGGAGAG
GGCCCAAGGGATGCAGACAGTGATGAAAACGACAAAGGTGAAAAGAAGAACAAGGGTACGTTTGATGGAGATAAGCTAGGAGATTTGAAG
GAGGAGGGTGATGTGATGGACAAGACCAATGGTTTACCAGTGCAGAATGGGATTGATGCAGACGTCAAAGATTTTAGCCGTACCCCTGGT
AATTGCCAGAACTCTGCTAATGAAGTGGATCTTCTGGGTCCAAACCAGAATGGTTCTGAGGGCTTAGCCCAGCTGACCAGCACCAATGGT
GCCAAGCCTGTGGAGGATTTCTCCAACATGGAGTCCCAGAGTGTCCCCTTGGACCCCATGGAACATGTGGGCATGGAGCCTCTTCAGTTT
GATTATTCAGGCACGCAGGTACCTGTGGACTCAGCAGCAGCAACTGTGGGACTTTTTGACTACAATTCTCAACAACAGCTGTTCCAAAGA
CCTAATGCGCTTGCTGTCCAGCAGTTGACAGCTGCTCAGCAGCAGCAGTATGCACTGGCAGCTGCTCATCAGCCGCACATCGCAGGTTTA
GCTCCCGCTGCGTTTGTCCCCAATCCATACATCATCAGCGCTGCTCCCCCAGGGACGGACCCCTACACAGCTGGATTGGCTGCAGCAGCG
ACACTAGGCCCAGCTGTGGTCCCTCACCAGTATTATGGAGTTACTCCCTGGGGAGTCTACCCTGCCAGTCTTTTCCAGCAGCAAGCTGCC
GCTGCCGCTGCAGCAACTAATTCAGCTAATCAACAGACCACCCCACAGGCTCAGCAAGGACAGCAGCAGGTTCTCCGTGGAGGAGCCAGC
CAACGTCCTTTGACCCCAAACCAGAACCAGCAGGGACAGCAAACGGATCCCCTTGTGGCAGCTGCAGCAGTGAATTCTGCCCTTGCATTT
GGACAAGGTCTGGCAGCAGGCATGCCAGGTTATCCGGTGTTGGCTCCTGCTGCTTACTATGACCAAACTGGTGCCCTTGTAGTGAATGCA
GGCGCGAGAAATGGTCTTGGAGCTCCTGTTCGACTTGTAGCTCCTGCCCCAGTCATCATTAGTTCCTCAGCTGCACAAGCAGCTGTTGCA
GCAGCCGCAGCTTCAGCAAATGGAGCAGCTGGTGGTCTTGCTGGAACAACAAATGGACCATTTCGCCCTTTAGGAACACAGCAGCCTCAG
CCCCAGCCCCAGCAGCAGCCCAATAACAACCTGGCATCCAGTTCTTTCTACGGCAACAACTCTCTGAACAGCAATTCACAGAGCAGCTCC
CTCTTCTCCCAGGGCTCTGCCCAGCCTGCCAACACATCCTTGGGATTCGGAAGTAGCAGTTCTCTCGGCGCCACCCTGGGATCCGCCCTT
GGAGGGTTTGGAACAGCAGTTGCAAACTCCAACACTGGCAGTGGCTCCCGCCGTGACTCCCTGACTGGCAGCAGTGACCTTTATAAGAGG
ACATCGAGCAGCTTGACCCCCATTGGACACAGTTTTTATAACGGCCTTAGCTTTTCCTCCTCTCCTGGACCCGTGGGCATGCCTCTCCCT
AGTCAGGGACCAGGACATTCACAGACACCACCTCCTTCCCTCTCTTCACATGGATCCTCTTCAAGCTTAAACCTGGGAGGACTCACGAAT
GGCAGTGGAAGATACATCTCTGCTGCTCCAGGCGCTGAAGCCAAGTACCGCAGTGCAAGCAGCGCCTCCAGCCTCTTCAGCCCGAGCAGC
ACTCTTTTCTCTTCCTCTCGTTTGCGATATGGAATGTCTGATGTCATGCCTTCTGGCAGGAGCAGGCTTTTGGAAGATTTTCGAAACAAC
CGGTACCCCAATTTACAACTGCGGGAGATTGCTGGACATATAATGGAATTTTCCCAAGACCAGCATGGGTCCAGATTCATTCAGCTGAAA
CTGGAGCGTGCCACACCAGCTGAGCGCCAGCTTGTCTTCAATGAAATCCTCCAGGCTGCCTACCAACTCATGGTGGATGTGTTTGGTAAT
TACGTCATTCAGAAGTTCTTTGAAATCCGGCGCAGGAGACCAACGCCTGCCATGCTGTTCCGGCTCTCAGAGCACTCCTCACCAGCTGTG
CAGCGCATTGCTGAGTCTCACCTGCAGTCTATCAGCAATTTGAATGAGAACCAGGCCTCAGAGGAGGAGGATGAGCTGGGGGAGCTTCGG
GAGCTGGGTTATCCAAGAGAGGAAGATGAGGAGGAAGAGGAGGATGATGAAGAAGAGGAAGAAGAAGAGGACAGCCAGGCTGAAGTCCTG
AAGGTCATCAGGCAGTCTGCTGGGCAAAAGACAACCTGTGGCCAGGGTCTGGAAGGGCCCTGGGAGCGCCCACCCCCTCTGGATGAGTCC
GAGAGAGATGGAGGCTCTGAGGACCAAGTGGAAGACCCAGCACTAAGTGAGCCTGGGGAGGAACCTCAGCGCCCTTCCCCCTCTGAGCCT
GGCACATAGGCACCCAGCCTGCATCTCCCAGGAGGAAGTGGAGGGGACATCGCTGTTCCCCAGAAACCCACTCTATCCTCACCCTGTTTT
GTGCTCTTCCCCTCGCCTGCTAGGGCTGCGGCTTCTGACTTCTAGAAGACTAAGGCTGGTCTGTGTTTGCTTGTTTGCCCACCTTTGGCT
GATACCCAGAGAACCTGGGCACTTGCTGCCTGATGCCCACCCCTGCCAGTCATTCCTCCATTCACCCAGCGGGAGGTGGGATGTGAGACA
GCCCACATTGGAAAATCCAGAAAACCGGGAACAGGGATTTGCCCTTCACAATTCTACTCCCCAGATCCTCTCCCCTGGACACAGGAGACC
CACAGGGCAGGACCCTAAGATCTGGGGAAAGGAGGTCCTGAGAACCTTGAGGTACCCTTAGATCCTTTTCTACCCACTTTCCTATGGAGG
ATTCCAAGTCACCACTTCTCTCACCGGCTTCTACCAGGGTCCAGGACTAAGGCGTTTTTCTCCATAGCCTCAACATTTTGGGAATCTTCC
CTTAATCACCCTTGCTCCTCCTGGGTGCCTGGAAGATGGACTGGCAGAGACCTCTTTGTTGCGTTTTGTGCTTTGATGCCAGGAATGCCG
CCTAGTTTATGTCCCCGGTGGGGCACACAGCGGGGGGCGCCAGGTTTTCCTTGTCCCCCAGCTGCTCTGCCCCTTTCCCCTTCTTCCCTG

>In-frame_ENST00000373742_ENST00000579000_TCGA-R6-A8W5_PUM1_chr1_31425080_-_PPP1R1B_chr17_37785422_length(amino acids)=992AA_start in transcript=0_stop in transcript=2978
MPLPPPGPGPEPIPGCTAPTQSPVGRHVVGVKGVGGMSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGSQAQPQPAANQ
ALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGE
GPRDADSDENDKGEKKNKGTFDGDKLGDLKEEGDVMDKTNGLPVQNGIDADVKDFSRTPGNCQNSANEVDLLGPNQNGSEGLAQLTSTNG
AKPVEDFSNMESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSAAATVGLFDYNSQQQLFQRPNALAVQQLTAAQQQQYALAAAHQPHIAGL
APAAFVPNPYIISAAPPGTDPYTAGLAAAATLGPAVVPHQYYGVTPWGVYPASLFQQQAAAAAAATNSANQQTTPQAQQGQQQVLRGGAS
QRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAAGMPGYPVLAPAAYYDQTGALVVNAGARNGLGAPVRLVAPAPVIISSSAAQAAVA
AAAASANGAAGGLAGTTNGPFRPLGTQQPQPQPQQQPNNNLASSSFYGNNSLNSNSQSSSLFSQGSAQPANTSLGFGSSSSLGATLGSAL
GGFGTAVANSNTGSGSRRDSLTGSSDLYKRTSSSLTPIGHSFYNGLSFSSSPGPVGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGLTN
GSGRYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLK
LERATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEIRRRRPTPAMLFRLSEHSSPAVQRIAESHLQSISNLNENQASEEEDELGELR
ELGYPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSAGQKTTCGQGLEGPWERPPPLDESERDGGSEDQVEDPALSEPGEEPQRPSPSEP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for PUM1-PPP1R1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PUM1-PPP1R1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PUM1-PPP1R1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePUM1C0004134Ataxia1GENOMICS_ENGLAND
HgenePUM1C0010417Cryptorchidism1GENOMICS_ENGLAND
HgenePUM1C0019193Hepatitis, Toxic1CTD_human
HgenePUM1C0036572Seizures1GENOMICS_ENGLAND
HgenePUM1C0557874Global developmental delay1GENOMICS_ENGLAND
HgenePUM1C0860207Drug-Induced Liver Disease1CTD_human
HgenePUM1C1262760Hepatitis, Drug-Induced1CTD_human
HgenePUM1C3658290Drug-Induced Acute Liver Injury1CTD_human
HgenePUM1C3714756Intellectual Disability1GENOMICS_ENGLAND
HgenePUM1C4025871Abnormality of the face1GENOMICS_ENGLAND
HgenePUM1C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgenePUM1C4279912Chemically-Induced Liver Toxicity1CTD_human
HgenePUM1C4693672SPINOCEREBELLAR ATAXIA 471GENOMICS_ENGLAND;UNIPROT
TgenePPP1R1BC0036341Schizophrenia5PSYGENET
TgenePPP1R1BC0005586Bipolar Disorder4PSYGENET
TgenePPP1R1BC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgenePPP1R1BC0007370Catalepsy1CTD_human
TgenePPP1R1BC0011570Mental Depression1PSYGENET
TgenePPP1R1BC0011581Depressive disorder1PSYGENET
TgenePPP1R1BC0013384Dyskinetic syndrome1CTD_human
TgenePPP1R1BC0152115Lingual-Facial-Buccal Dyskinesia1CTD_human
TgenePPP1R1BC0221169Hemiballismus1CTD_human
TgenePPP1R1BC0232766Asterixis1CTD_human
TgenePPP1R1BC0233612Waxy flexibility1CTD_human
TgenePPP1R1BC0427086Involuntary Movements1CTD_human
TgenePPP1R1BC0454606Oral Dyskinesia1CTD_human
TgenePPP1R1BC0752196Ballismus1CTD_human