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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:PUM1-SDC3 (FusionGDB2 ID:70249)

Fusion Gene Summary for PUM1-SDC3

check button Fusion gene summary
Fusion gene informationFusion gene name: PUM1-SDC3
Fusion gene ID: 70249
HgeneTgene
Gene symbol

PUM1

SDC3

Gene ID

9698

9672

Gene namepumilio RNA binding family member 1syndecan 3
SynonymsHSPUM|PUMH|PUMH1|PUML1|SCA47SDCN|SYND3
Cytomap

1p35.2

1p35.2

Type of geneprotein-codingprotein-coding
Descriptionpumilio homolog 1pumilio-1syndecan-3N-syndecansyndecan neural typesyndecan proteoglycan 3
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000424085, ENST00000257075, 
ENST00000373747, ENST00000426105, 
ENST00000440538, ENST00000373741, 
ENST00000423018, ENST00000373742, 
ENST00000490546, 		ENST00000336798, 
ENST00000339394, ENST00000471567, 
Fusion gene scores* DoF score38 X 31 X 15=176709 X 8 X 6=432
# samples 5611
** MAII scorelog2(56/17670*10)=-4.97973140249401
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/432*10)=-1.97352778863881
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PUM1 [Title/Abstract] AND SDC3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPUM1(31532051)-SDC3(31351587), # samples:5
Anticipated loss of major functional domain due to fusion event.PUM1-SDC3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PUM1-SDC3 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePUM1

GO:0010608

posttranscriptional regulation of gene expression

25100735

HgenePUM1

GO:0043488

regulation of mRNA stability

26724866

HgenePUM1

GO:0051726

regulation of cell cycle

20818387

HgenePUM1

GO:0051983

regulation of chromosome segregation

26724866

HgenePUM1

GO:1900246

positive regulation of RIG-I signaling pathway

25340845

HgenePUM1

GO:2000637

positive regulation of gene silencing by miRNA

20818387|22345517


check buttonFusion gene breakpoints across PUM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SDC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-ZF-A9R1-01APUM1chr1

31532146

-SDC3chr1

31351587

-
ChimerDB4BRCATCGA-A2-A25F-01APUM1chr1

31532051

-SDC3chr1

31351587

-
ChimerDB4BRCATCGA-EW-A1PH-01APUM1chr1

31532051

-SDC3chr1

31351587

-
ChimerDB4ESCATCGA-LN-A49L-01APUM1chr1

31532051

-SDC3chr1

31351587

-
ChimerDB4BRCATCGA-EW-A1PH-01APUM1chr1

31532051

-SDC3chr1

31351587

-
ChimerDB4ESCATCGA-LN-A49LPUM1chr1

31532051

-SDC3chr1

31351587

-
ChimerDB4ESCATCGA-LN-A49LPUM1chr1

31532146

-SDC3chr1

31351587

-
ChimerDB4ESCATCGA-LN-A49LPUM1chr1

31528160

-SDC3chr1

31351587

-


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Fusion Gene ORF analysis for PUM1-SDC3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000424085ENST00000336798PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-3CDSENST00000424085ENST00000339394PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-5UTRENST00000424085ENST00000471567PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-3CDSENST00000257075ENST00000336798PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-3CDSENST00000257075ENST00000339394PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-5UTRENST00000257075ENST00000471567PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-3CDSENST00000373747ENST00000336798PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-3CDSENST00000373747ENST00000339394PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-5UTRENST00000373747ENST00000471567PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-3CDSENST00000426105ENST00000336798PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-3CDSENST00000426105ENST00000339394PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-5UTRENST00000426105ENST00000471567PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-3CDSENST00000440538ENST00000336798PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-3CDSENST00000440538ENST00000339394PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-5UTRENST00000440538ENST00000471567PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-3CDSENST00000373741ENST00000336798PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-3CDSENST00000373741ENST00000339394PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-5UTRENST00000373741ENST00000471567PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-3CDSENST00000423018ENST00000336798PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-3CDSENST00000423018ENST00000339394PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-5UTRENST00000423018ENST00000471567PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-3CDSENST00000373742ENST00000336798PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-3CDSENST00000373742ENST00000339394PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-5UTRENST00000373742ENST00000471567PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-3CDSENST00000490546ENST00000336798PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-3CDSENST00000490546ENST00000339394PUM1chr1

31532146

-SDC3chr1

31351587

-
intron-5UTRENST00000490546ENST00000471567PUM1chr1

31532146

-SDC3chr1

31351587

-
Frame-shiftENST00000424085ENST00000336798PUM1chr1

31532051

-SDC3chr1

31351587

-
Frame-shiftENST00000424085ENST00000339394PUM1chr1

31532051

-SDC3chr1

31351587

-
5CDS-5UTRENST00000424085ENST00000471567PUM1chr1

31532051

-SDC3chr1

31351587

-
Frame-shiftENST00000257075ENST00000336798PUM1chr1

31532051

-SDC3chr1

31351587

-
Frame-shiftENST00000257075ENST00000339394PUM1chr1

31532051

-SDC3chr1

31351587

-
5CDS-5UTRENST00000257075ENST00000471567PUM1chr1

31532051

-SDC3chr1

31351587

-
Frame-shiftENST00000373747ENST00000336798PUM1chr1

31532051

-SDC3chr1

31351587

-
Frame-shiftENST00000373747ENST00000339394PUM1chr1

31532051

-SDC3chr1

31351587

-
5CDS-5UTRENST00000373747ENST00000471567PUM1chr1

31532051

-SDC3chr1

31351587

-
Frame-shiftENST00000426105ENST00000336798PUM1chr1

31532051

-SDC3chr1

31351587

-
Frame-shiftENST00000426105ENST00000339394PUM1chr1

31532051

-SDC3chr1

31351587

-
5CDS-5UTRENST00000426105ENST00000471567PUM1chr1

31532051

-SDC3chr1

31351587

-
Frame-shiftENST00000440538ENST00000336798PUM1chr1

31532051

-SDC3chr1

31351587

-
Frame-shiftENST00000440538ENST00000339394PUM1chr1

31532051

-SDC3chr1

31351587

-
5CDS-5UTRENST00000440538ENST00000471567PUM1chr1

31532051

-SDC3chr1

31351587

-
In-frameENST00000373741ENST00000336798PUM1chr1

31532051

-SDC3chr1

31351587

-
In-frameENST00000373741ENST00000339394PUM1chr1

31532051

-SDC3chr1

31351587

-
5CDS-5UTRENST00000373741ENST00000471567PUM1chr1

31532051

-SDC3chr1

31351587

-
Frame-shiftENST00000423018ENST00000336798PUM1chr1

31532051

-SDC3chr1

31351587

-
Frame-shiftENST00000423018ENST00000339394PUM1chr1

31532051

-SDC3chr1

31351587

-
5CDS-5UTRENST00000423018ENST00000471567PUM1chr1

31532051

-SDC3chr1

31351587

-
In-frameENST00000373742ENST00000336798PUM1chr1

31532051

-SDC3chr1

31351587

-
In-frameENST00000373742ENST00000339394PUM1chr1

31532051

-SDC3chr1

31351587

-
5CDS-5UTRENST00000373742ENST00000471567PUM1chr1

31532051

-SDC3chr1

31351587

-
intron-3CDSENST00000490546ENST00000336798PUM1chr1

31532051

-SDC3chr1

31351587

-
intron-3CDSENST00000490546ENST00000339394PUM1chr1

31532051

-SDC3chr1

31351587

-
intron-5UTRENST00000490546ENST00000471567PUM1chr1

31532051

-SDC3chr1

31351587

-
intron-3CDSENST00000424085ENST00000336798PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-3CDSENST00000424085ENST00000339394PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-5UTRENST00000424085ENST00000471567PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-3CDSENST00000257075ENST00000336798PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-3CDSENST00000257075ENST00000339394PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-5UTRENST00000257075ENST00000471567PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-3CDSENST00000373747ENST00000336798PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-3CDSENST00000373747ENST00000339394PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-5UTRENST00000373747ENST00000471567PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-3CDSENST00000426105ENST00000336798PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-3CDSENST00000426105ENST00000339394PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-5UTRENST00000426105ENST00000471567PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-3CDSENST00000440538ENST00000336798PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-3CDSENST00000440538ENST00000339394PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-5UTRENST00000440538ENST00000471567PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-3CDSENST00000373741ENST00000336798PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-3CDSENST00000373741ENST00000339394PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-5UTRENST00000373741ENST00000471567PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-3CDSENST00000423018ENST00000336798PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-3CDSENST00000423018ENST00000339394PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-5UTRENST00000423018ENST00000471567PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-3CDSENST00000373742ENST00000336798PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-3CDSENST00000373742ENST00000339394PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-5UTRENST00000373742ENST00000471567PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-3CDSENST00000490546ENST00000336798PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-3CDSENST00000490546ENST00000339394PUM1chr1

31528160

-SDC3chr1

31351587

-
intron-5UTRENST00000490546ENST00000471567PUM1chr1

31528160

-SDC3chr1

31351587

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373741PUM1chr131532051-ENST00000336798SDC3chr131351587-706967720413324427
ENST00000373741PUM1chr131532051-ENST00000339394SDC3chr131351587-19446771131867584
ENST00000373742PUM1chr131532051-ENST00000336798SDC3chr131351587-686347118353118427
ENST00000373742PUM1chr131532051-ENST00000339394SDC3chr131351587-173847101661553

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373741ENST00000336798PUM1chr131532051-SDC3chr131351587-0.0108077680.9891922
ENST00000373741ENST00000339394PUM1chr131532051-SDC3chr131351587-0.018054870.98194516
ENST00000373742ENST00000336798PUM1chr131532051-SDC3chr131351587-0.0107515520.9892484
ENST00000373742ENST00000339394PUM1chr131532051-SDC3chr131351587-0.0201213580.97987866

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Fusion Genomic Features for PUM1-SDC3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for PUM1-SDC3


check button Go to

FGviewer for the breakpoints of chr1:31532051-chr1:31351587

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSDC3chr1:31532051chr1:31351587ENST0000033939405115_30246.0443.0Compositional biasNote=Ser/Thr-rich (mucin-like)
TgeneSDC3chr1:31532051chr1:31351587ENST0000033939405409_44246.0443.0Topological domainCytoplasmic
TgeneSDC3chr1:31532051chr1:31351587ENST0000033939405388_40846.0443.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePUM1chr1:31532051chr1:31351587ENST00000257075-222393_613121.01187.0Compositional biasNote=Ala-rich
HgenePUM1chr1:31532051chr1:31351587ENST00000257075-222475_523121.01187.0Compositional biasNote=Gln-rich
HgenePUM1chr1:31532051chr1:31351587ENST00000257075-222642_815121.01187.0Compositional biasNote=Ser-rich
HgenePUM1chr1:31532051chr1:31351587ENST00000426105-222393_613121.01189.0Compositional biasNote=Ala-rich
HgenePUM1chr1:31532051chr1:31351587ENST00000426105-222475_523121.01189.0Compositional biasNote=Gln-rich
HgenePUM1chr1:31532051chr1:31351587ENST00000426105-222642_815121.01189.0Compositional biasNote=Ser-rich
HgenePUM1chr1:31532051chr1:31351587ENST00000440538-222393_613121.01163.0Compositional biasNote=Ala-rich
HgenePUM1chr1:31532051chr1:31351587ENST00000440538-222475_523121.01163.0Compositional biasNote=Gln-rich
HgenePUM1chr1:31532051chr1:31351587ENST00000440538-222642_815121.01163.0Compositional biasNote=Ser-rich
HgenePUM1chr1:31532051chr1:31351587ENST00000257075-222828_1168121.01187.0DomainPUM-HD
HgenePUM1chr1:31532051chr1:31351587ENST00000426105-222828_1168121.01189.0DomainPUM-HD
HgenePUM1chr1:31532051chr1:31351587ENST00000440538-222828_1168121.01163.0DomainPUM-HD
HgenePUM1chr1:31532051chr1:31351587ENST00000257075-2221028_1063121.01187.0RepeatPumilio 6
HgenePUM1chr1:31532051chr1:31351587ENST00000257075-2221064_1099121.01187.0RepeatPumilio 7
HgenePUM1chr1:31532051chr1:31351587ENST00000257075-2221103_1142121.01187.0RepeatPumilio 8
HgenePUM1chr1:31532051chr1:31351587ENST00000257075-222848_883121.01187.0RepeatPumilio 1
HgenePUM1chr1:31532051chr1:31351587ENST00000257075-222884_919121.01187.0RepeatPumilio 2
HgenePUM1chr1:31532051chr1:31351587ENST00000257075-222920_955121.01187.0RepeatPumilio 3
HgenePUM1chr1:31532051chr1:31351587ENST00000257075-222956_991121.01187.0RepeatPumilio 4
HgenePUM1chr1:31532051chr1:31351587ENST00000257075-222992_1027121.01187.0RepeatPumilio 5
HgenePUM1chr1:31532051chr1:31351587ENST00000426105-2221028_1063121.01189.0RepeatPumilio 6
HgenePUM1chr1:31532051chr1:31351587ENST00000426105-2221064_1099121.01189.0RepeatPumilio 7
HgenePUM1chr1:31532051chr1:31351587ENST00000426105-2221103_1142121.01189.0RepeatPumilio 8
HgenePUM1chr1:31532051chr1:31351587ENST00000426105-222848_883121.01189.0RepeatPumilio 1
HgenePUM1chr1:31532051chr1:31351587ENST00000426105-222884_919121.01189.0RepeatPumilio 2
HgenePUM1chr1:31532051chr1:31351587ENST00000426105-222920_955121.01189.0RepeatPumilio 3
HgenePUM1chr1:31532051chr1:31351587ENST00000426105-222956_991121.01189.0RepeatPumilio 4
HgenePUM1chr1:31532051chr1:31351587ENST00000426105-222992_1027121.01189.0RepeatPumilio 5
HgenePUM1chr1:31532051chr1:31351587ENST00000440538-2221028_1063121.01163.0RepeatPumilio 6
HgenePUM1chr1:31532051chr1:31351587ENST00000440538-2221064_1099121.01163.0RepeatPumilio 7
HgenePUM1chr1:31532051chr1:31351587ENST00000440538-2221103_1142121.01163.0RepeatPumilio 8
HgenePUM1chr1:31532051chr1:31351587ENST00000440538-222848_883121.01163.0RepeatPumilio 1
HgenePUM1chr1:31532051chr1:31351587ENST00000440538-222884_919121.01163.0RepeatPumilio 2
HgenePUM1chr1:31532051chr1:31351587ENST00000440538-222920_955121.01163.0RepeatPumilio 3
HgenePUM1chr1:31532051chr1:31351587ENST00000440538-222956_991121.01163.0RepeatPumilio 4
HgenePUM1chr1:31532051chr1:31351587ENST00000440538-222992_1027121.01163.0RepeatPumilio 5
TgeneSDC3chr1:31532051chr1:31351587ENST00000339394051_38746.0443.0Topological domainExtracellular


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Fusion Gene Sequence for PUM1-SDC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000373741_ENST00000336798_TCGA-A2-A25F-01A_PUM1_chr1_31532051_-_SDC3_chr1_31351587_length(transcript)=7069nt_BP=677nt
AACCCCGCGTGCCCAGCTCCAGGCCGTGTTCTCCCAGGTGCGGGCCGGCGGGACCCCGCCTTCGGCCCTGGCGGCGCGCGCTCGCCTAGC
GGGCGGGCACTCGCGCGCAGCGTTTGTGTTGCCTGCGAGTTTCCCGAGTTCACACAGGCCCTGGGTTGGCATGGCAACCAGGCAACCTGT
TCCAGAGCCGCCAGCCTTCTCCGCACATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGT
CCCCAGTGGGCCGCCATGTTGTCGGAGTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGG
ACTCTTTCAGCCCCCACCTGAAACATCACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAG
CGCAGCCACAACCAGCTGCAAATCAGGCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCC
AGGACGACGCTATGGTGGACTACTTCTTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATA
GCAAACATCGATGGCCTACTGGGGATAACATTCATGCAGAACATCAGGCCCAGCGCTGGCGCAGTGAGAACTTCGAGAGACCCGTGGACC
TGGAGGGCTCTGGGGATGATGACTCCTTTCCCGATGATGAACTGGATGACCTCTACTCGGGGTCGGGCTCGGGCTGTAAGTACCCCCCTC
CCTACCTCTGCCTGGGGGCAGTGACCAGTCTGTATCCAGCCTCAACTCTGAGAAGCCCACGGGGGGCTTGCTTCAGTGAGGCAGGGGGCA
TTCACTGCCTGGGTCAGGCAAGTTCTTCTTGCTCTGGATCCCCAGAACAAGAAGGGCAGAACATCCTTCTGGGGATAGAACAAGACCTGG
GAGGACCTCAGGGCCCAGAATGTCCAGGTCTCCAGGGTCCCACGTCTGCATCTTTGTGTGTGCTATGTGGCTTTCTCTGCAGACCTTGCT
TGGTTCCGGTGGTCCCGTCAGGTGCAATAAGCTGTGGCCAATGGTGGGGTTAGGGCAGTGATGACACAGGGCAGGTGCTTCAAGTGGTGC
CTGGGATGGCCCCGCCCTGGGGAAGGGGAGCCAGGTCAGCTGGGTCTAGCAGAATCTCGGGAGAGAAGGGCACCGCGAACCCCACTCTGC
CATGTAGCAACTGTGTGCCCCTCGGTGCTCCCCCTCCCTGAATCCCTGTATTTTCACCTGTGGATGGTGAGAAATACGACTTCTTCTCAG
TGCCTCTAGGAGGGTTTGGGATAGGAAGCTGGGGTCTGGCACAGAGGAGGAGCTCTCAAAATGGTAGCAAAAAGAAGGCAGCTGAGACTG
GGCCCAGTGAGGGCACGGGCTGGCATCTGAGGAGATGGTACGGGGTCTGCACGCCACAGAGCTGGCTCCCCACAGCCCTCGCCTCTGGTC
TCCCCTCCTTAGCCAAGTCCTTTGAGCCTCTTTCAAATTAATCTTTGTAAAACCCGTTTATATTGGGTCACATCTCTATTCGCAAAGTTC
CCTGGCTCCCCTCCCTCCTGCCTGGTTCCGAGCCCAGGAGCTGGCTGTGGCTTCTCCCTCCCCCATCCCCTACTCCCCATCTCATTTCCT
CCCAAGTTCCTTCACTGTCCCGGCTTTGCGTCAGCCAGATTGCTCAAGCAGTTCCCCTGCCTCAAGGGCTTCTTTTCCCTTTTACCCTCC
GCCTCTGCCTCTGGGGGAAGCCCTTAGTGTACCACCCCTGCCTTGAGCTTGTGGTAGGGGTGCCTTTGGGGTCTGACTCTTCCCAGAATG
CCACTCCTGTGTTCCCCTGCAAGCCCCAGCAAGTTTTGCAGCCAGTAGCGCCTCAGTTGCTGCTGCCTGGATTCAACCTCATAGAAACTG
TAGGCTGGGTGGGCAGGAATAGTCAAGGAAGGCTTCCCGGGAGAGGCGGCCCCCAGAATTTTTGACTTGGCAGAGAGAAGTTGGGGAACA
TCAGCAACTGACCACCTTTAGCTGGGCTGTGCCTTCCTCCTTTCTCTCATCTTTTCTGGGAAAATTGGGTAAAGAGAGGGGGTTGGGAGA
CCTAATCTTGATGGCCATTGCTTACCTGGGATCCTCATGCCCCTCACAACCACCCAGCTCCCTAGCTCTCTCCCTCTCCCCCACCCCCTC
AGACTTCGAGCAGGAGTCGGGCATTGAGACAGCCATGCGCTTCAGCCCAGATGTAGCCCTGGCGGTGTCCACCACACCTGCGGTGCTGCC
CACCACGAACATCCAGCCTGTGGGCACACCATTTGAAGAGCTCCCCTCTGAGCGCCCCACCCTGGAGCCAGCCACCAGCCCCCTGGTGGT
GACAGAAGTCCCGGAAGAGCCCAGCCAGAGAGCCACCACCGTCTCCACTACCATGGCTACCACTGCTGCCACAAGCACAGGGGACCCGAC
TGTGGCCACAGTGCCTGCCACAGTGGCCACCGCCACCCCCAGCACCCCTGCAGCACCCCCTTTTACGGCCACCACTGCTGTTATAAGGAC
CACTGGCGTACGGAGGCTTCTGCCTCTCCCACTGACCACAGTGGCTACGGCACGGGCCACTACCCCCGAGGCGCCCTCCCCGCCCACCAC
GGCGGCTGTCTTGGACACCGAGGCCCCAACACCCAGGCTGGTCAGCACAGCTACCTCCCGGCCAAGAGCCCTTCCCAGGCCGGCCACCAC
CCAGGAGCCTGACATCCCTGAGAGGAGCACCCTGCCCCTGGGGACCACTGCCCCTGGACCCACAGAGGTGGCTCAGACCCCAACTCCAGA
GACCTTCCTGACCACAATCCGGGATGAGCCAGAGGTTCCGGTGAGTGGGGGGCCCAGTGGAGACTTCGAGCTGCCAGAAGAAGAGACCAC
ACAACCAGACACAGCCAATGAGGTGGTAGCTGTGGGAGGGGCTGCGGCCAAGGCATCATCTCCACCTGGGACACTGCCCAAGGGTGCCCG
CCCGGGCCCTGGCCTCCTGGACAATGCCATCGACTCGGGCAGCTCAGCTGCTCAGCTGCCTCAGAAGAGTATCCTGGAGCGGAAGGAGGT
GCTCGTAGCTGTGATTGTGGGCGGGGTGGTGGGCGCCCTCTTTGCTGCCTTCTTGGTCACACTGCTCATCTATCGTATGAAGAAAAAGGA
TGAGGGCAGCTACACGCTGGAGGAACCCAAGCAGGCGAGCGTCACATACCAGAAGCCTGACAAGCAGGAGGAGTTCTATGCCTAGTGGAG
CCACAGTGCCTCCCTGCAGCCTCAACACCACCCTGCTGTCCAGTCCCCAGCCTGGCCCCACCAGCCCAAGCCTGGGACTGGGCCTGGAAC
CTGGCCCCAGTTCTTCTCTGCCCTCTCTCCCAAGGTCTGCCCAGGCTGCCAGCCTCACACAGATCTTCCCCGAGGAAGAGGGGCTGCTGC
CATCTGCCCCAGACTGTGCCCTTACGAGCTCATCTCTTGTTCCCCTCATCCCTGCCACCAGTCTGGGGCTTCAGGACCTCATGTCAGATG
GATGGGAGGAAGAAAGCTCCTGATTGGCTGGTGGTGGAAGAAAGGGTGGGGCTTGAGATGAGCCTGAGCCCTGACTTGGCACCCACAGTG
CTCACTGAGATCTCCTTTTTGGGGCAGAGAGGCACTCAGGCTGGTTTCCAGGACAAACATTTGGTAAACACAGCCCTTGAAATCATCTAG
ACACTGCAACCTCTTGCTCGTATCCCAGGGCCTCTCTCTAGCTGGGTGAGAGGGTGTCCCTTGTCACCAGCCTGTTTTGTCCTGGTCTCT
CTGGGGTTGTTGAATCTCTCCTCTTGCCTGCCAAGTACACATGTACCCAGACTTCATTTCTTTCTGCATCTTCCCCCAAGAAACAGCTTC
CTGAGGGTGCTGGGGCAGCCACTGGTGAGGAGGGGCTGCTCTGATGTCCCTCCTATGAGGGGACTCTGCACAGACACCATTGCCCACACT
ATCACCATATTTTCACTCAGTCACACACAAGACAAAAGCATGCAATGACAAAACCATACGCAATCCTGACCGCCCAGCCAATCAAGACAT
ATCACAGAACACACGCGTCCTTCCAAGAATGTTTATCCTCATGCATCACTTACACACCCCCAGACACGTACTGCAATGCAAGTCACTAGT
CATGGTCACATGACAGTGACAGTGTGGCCTCCTCCTACCCCAAATACACCCACACTCTGGCACCACACACATTGTCTCCAGCTTTCAGGC
TTACTGGGGAGGGTGGAATCGAGCCAGAACAATCAGCCCATATTGGGTCCCCCTAAGTTGCCCCGTCATACTCAGTCCCATGCCATGGTG
CCCACACCAACCATGCAGCCGCCAACCCCAGCCAGTGTCAGACACAATCCCATGTGGATGCACAGTCTCACTCCACATGACCTGCTCTCA
ATGCTGGAGGGAAACAGGCAGGCCCTTGCCTTTCTCGGAAAAAGTGTGGGGCCACAGCCCTTTTAGGGCATTGCATGCAGGTGGGCCTGG
CTTCACCCCTACCTGCTTCCTCCCCACCGCAGCTGGCAGAGGGGGAGGTTTGGGGCCAGACCCCCACTAGCTGGGAGCCTGGGGGCTCCT
CTAAGGCTGAGGAAGGAAATTTGGCCCCAGGTTGTTGGGGGGTCTTGGGTCTCCCAGGACGGAAGGCCCAGGGCAGGGAGGGGGCATGTG
GTTGGGCTCCTTTATCTCCCTGTGTCCCCTTCCTGCTTTGAGCTAGGGGGCTGACTCTGCCTCCCAGGACACAAGTCTCCAAAGTGCCTG
TGAGGGCGGGCCCTCCGCACCCTCTGCCCTCTGCCTGGCAGGCCAACCTCAGCCCACCTGCCCAGAGGCCCTCCCTGTGGACACCCCCTC
ACCTATTTGGCCAAACAATTCTGGCTGCAGCTTCAGGGGCCATGGCTGGAAGCAGCCCCTGCAGATCCCTCAGGCCCCGAGGTCAGGGTT
TGAGGGATGAGACCAGGTGATAGTGGGGGAGGGGTTACTTCCTTTGTTACCTAGCAAGTAGGGCTATTTCCATCGGTATTTTAAATGTGG
GGTCACAGATCTTTTGGGGAGGGTGTGCTTGGCAGGGGGCCTCTTGGAGCCAAAGGGATGTGGTGTGAGTTGCGATTGGCTGGCACTCAC
ACCCCCACCCCTCACCCACATCCCAGATTCAAGTCAGGAAGGCAGGTTTTATTTCAGGGCCCTTTTCAAGATGCCCTGGCAGCAGATTTC
TGCAGGATGAGGGGTAGCGGTGTGTAGGCAGTGAGGGGGAGGTTCCAGGGGCTGTCCCACAGCCTGTCTTTTCCAGGCTGGGCTCCATCT
TCCAGTCCCAAAACCCTCCTTCACAGGGCCCAGAGGCTTGTGAGGAAGCCAGGTGGACCCAGCCTTAGAAGAGTGGGCATGGGGGGCCCC
TGATATCTGGAGGGGGCGGGTTGGCCTCAGTCATCTTTGGAGCAGAAGGGCTGGGTCCTGGGGCCACAGACCACAAGGCTCAGCCTCCCT
ACCCTGCTCCCTGGGGTGCTGCTGTCTTGGAGAGCACAGCTCTGGTGAGACGGCCTGGGCAGGCCGAGGCTGAGAAACCAGGGAGGATAG
AGGAGAAAAGGGCTTGGGCCCCCAGCCCCAGAAGATGCTGGACCCCAGGTGGGAGACCCAACAGTGGGTGCAGTTTCTCAGTAGGGCTGG
AGCCAATGGTGGGGGTGGCCCCGGCAGGCCTGGCTCCTCACATCCCAGGGGTTGGCTTCTGATTTGGGGCTTGGGCTCCAGGCACTGGCT
TCTCTTCTCTGTGTCCTTAGCATTTGAGAGAAGAGGCCAGGGGCCTTGTTCATGGATCCCTGGACCCAAGGCAGATGTCCAGGCTTTATC
CTCCTGAGGATGAGGAGTCTGACCAGCCCAAATCTGCCCTGGCCGGCCTGACCGGGGCAAGGCAGTCCAAGAGAGTTCAGTGAGGACCAG
CTAGGCTCTCCCAGGTGCAATGTGGGTGCAGGGCCCTCATGTCCCCCTACCCCTGCCTGTGATGGAGTGTTCTGAGGGGCTTTGGCATTT
GCTGGAAGCACAGGGAGTTCCAAATGAGAGGGAGCTTCTGTGGCTTGAGAGCCTCTGGGGCCTTGGCTGCCAGAGCACGAGGCAGGCCAG
GACCTGGAGAGCCCAGACCCTGTCTCCAGGAGGCCAGGAGGCCAGATGGGGGCCTTGCCTGAAAGACTGGTCCCCTTGATCGCTGGAGGC
ATGTGGGTGGCAACCAGGGCTGGGCAGGGCTTAGGGTGTGTGGGCCAAACCCCCCTGGGGTTGGCAAAGCCGCCTGTCAGGCCTCCTGGT
GGGGGCCCCTGGACACAGGGAGCAGACCCTCTGCCTCATGGGGTAGGAGTGGCTGCCTCCTGTGTTCTCTGGATTTCTTCTCCCAACAAC
TACAACCCTGGACTTGCCTCCCCAGGCCTCTTGCCTGTAAATAGAAGCCCGCAAACTGTACAGATTTACAGAGGCATCGAGACTGGGCCC
TGGGAGTTGCCATCTGAGAGCCGATGGCCCCAGCATCCCCCAGGTGCCTGCCTGGCACCACAGTGACCCTGGCCTCAGCGTGGCAAATGC
ATGTAAATATTTTTCGTAGGCAGCGTGGCTCCAGAGAGCCCCCTGAAGACAGTGTCCCTCCCTCCTGTGAGTCCTTTCTCCTGTACAGAA
CCTGCCTGGGGTGGGTGGGGGTCTGCCATTCCCTCCCCCAGGCCTTCCCTGCCCCTTCTCTCCCCTGTAACCTGTTTATTAACCATACCT
GTCCTGAGTTCATGGCCAAAACCTTAAATAAGAAAAACAAAAGAAAAAGACAGTGGAAAAAAGAGACCAAGGCGCCTGCCCCACTGCGGG
TACTCTCCTGTTCCAGCCTTGTGAAGGAACTGGTTTTGTTTTTGTTTTTTTTTTTTTTTTTTTTTTTTTGTTTGTTTGTTTTTTTAACAC

>In-frame_ENST00000373741_ENST00000336798_TCGA-A2-A25F-01A_PUM1_chr1_31532051_-_SDC3_chr1_31351587_length(amino acids)=427AA_start in transcript=2041_stop in transcript=3324
MTWQREVGEHQQLTTFSWAVPSSFLSSFLGKLGKERGLGDLILMAIAYLGSSCPSQPPSSLALSLSPTPSDFEQESGIETAMRFSPDVAL
AVSTTPAVLPTTNIQPVGTPFEELPSERPTLEPATSPLVVTEVPEEPSQRATTVSTTMATTAATSTGDPTVATVPATVATATPSTPAAPP
FTATTAVIRTTGVRRLLPLPLTTVATARATTPEAPSPPTTAAVLDTEAPTPRLVSTATSRPRALPRPATTQEPDIPERSTLPLGTTAPGP
TEVAQTPTPETFLTTIRDEPEVPVSGGPSGDFELPEEETTQPDTANEVVAVGGAAAKASSPPGTLPKGARPGPGLLDNAIDSGSSAAQLP

--------------------------------------------------------------
>In-frame_ENST00000373741_ENST00000339394_TCGA-A2-A25F-01A_PUM1_chr1_31532051_-_SDC3_chr1_31351587_length(transcript)=1944nt_BP=677nt
AACCCCGCGTGCCCAGCTCCAGGCCGTGTTCTCCCAGGTGCGGGCCGGCGGGACCCCGCCTTCGGCCCTGGCGGCGCGCGCTCGCCTAGC
GGGCGGGCACTCGCGCGCAGCGTTTGTGTTGCCTGCGAGTTTCCCGAGTTCACACAGGCCCTGGGTTGGCATGGCAACCAGGCAACCTGT
TCCAGAGCCGCCAGCCTTCTCCGCACATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGT
CCCCAGTGGGCCGCCATGTTGTCGGAGTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGG
ACTCTTTCAGCCCCCACCTGAAACATCACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAG
CGCAGCCACAACCAGCTGCAAATCAGGCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCC
AGGACGACGCTATGGTGGACTACTTCTTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATA
GCAAACATCGATGGCCTACTGGGGATAACATTCATGCAGAACATCAGGCCCAGCGCTGGCGCAGTGAGAACTTCGAGAGACCCGTGGACC
TGGAGGGCTCTGGGGATGATGACTCCTTTCCCGATGATGAACTGGATGACCTCTACTCGGGGTCGGGCTCGGGCTACTTCGAGCAGGAGT
CGGGCATTGAGACAGCCATGCGCTTCAGCCCAGATGTAGCCCTGGCGGTGTCCACCACACCTGCGGTGCTGCCCACCACGAACATCCAGC
CTGTGGGCACACCATTTGAAGAGCTCCCCTCTGAGCGCCCCACCCTGGAGCCAGCCACCAGCCCCCTGGTGGTGACAGAAGTCCCGGAAG
AGCCCAGCCAGAGAGCCACCACCGTCTCCACTACCATGGCTACCACTGCTGCCACAAGCACAGGGGACCCGACTGTGGCCACAGTGCCTG
CCACAGTGGCCACCGCCACCCCCAGCACCCCTGCAGCACCCCCTTTTACGGCCACCACTGCTGTTATAAGGACCACTGGCGTACGGAGGC
TTCTGCCTCTCCCACTGACCACAGTGGCTACGGCACGGGCCACTACCCCCGAGGCGCCCTCCCCGCCCACCACGGCGGCTGTCTTGGACA
CCGAGGCCCCAACACCCAGGCTGGTCAGCACAGCTACCTCCCGGCCAAGAGCCCTTCCCAGGCCGGCCACCACCCAGGAGCCTGACATCC
CTGAGAGGAGCACCCTGCCCCTGGGGACCACTGCCCCTGGACCCACAGAGGTGGCTCAGACCCCAACTCCAGAGACCTTCCTGACCACAA
TCCGGGATGAGCCAGAGGTTCCGGTGAGTGGGGGGCCCAGTGGAGACTTCGAGCTGCCAGAAGAAGAGACCACACAACCAGACACAGCCA
ATGAGGTGGTAGCTGTGGGAGGGGCTGCGGCCAAGGCATCATCTCCACCTGGGACACTGCCCAAGGGTGCCCGCCCGGGCCCTGGCCTCC
TGGACAATGCCATCGACTCGGGCAGCTCAGCTGCTCAGCTGCCTCAGAAGAGTATCCTGGAGCGGAAGGAGGTGCTCGTAGCTGTGATTG
TGGGCGGGGTGGTGGGCGCCCTCTTTGCTGCCTTCTTGGTCACACTGCTCATCTATCGTATGAAGAAAAAGGATGAGGGCAGCTACACGC
TGGAGGAACCCAAGCAGGCGAGCGTCACATACCAGAAGCCTGACAAGCAGGAGGAGTTCTATGCCTAGTGGAGCCACAGTGCCTCCCTGC

>In-frame_ENST00000373741_ENST00000339394_TCGA-A2-A25F-01A_PUM1_chr1_31532051_-_SDC3_chr1_31351587_length(amino acids)=584AA_start in transcript=113_stop in transcript=1867
MCCLRVSRVHTGPGLAWQPGNLFQSRQPSPHMPLPPPGPGPEPIPGCTAPTQSPVGRHVVGVKGVGGMSVACVLKRKAVLWQDSFSPHLK
HHPQEPANPNMPVVLTSGTGSQAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTG
DNIHAEHQAQRWRSENFERPVDLEGSGDDDSFPDDELDDLYSGSGSGYFEQESGIETAMRFSPDVALAVSTTPAVLPTTNIQPVGTPFEE
LPSERPTLEPATSPLVVTEVPEEPSQRATTVSTTMATTAATSTGDPTVATVPATVATATPSTPAAPPFTATTAVIRTTGVRRLLPLPLTT
VATARATTPEAPSPPTTAAVLDTEAPTPRLVSTATSRPRALPRPATTQEPDIPERSTLPLGTTAPGPTEVAQTPTPETFLTTIRDEPEVP
VSGGPSGDFELPEEETTQPDTANEVVAVGGAAAKASSPPGTLPKGARPGPGLLDNAIDSGSSAAQLPQKSILERKEVLVAVIVGGVVGAL

--------------------------------------------------------------
>In-frame_ENST00000373742_ENST00000336798_TCGA-A2-A25F-01A_PUM1_chr1_31532051_-_SDC3_chr1_31351587_length(transcript)=6863nt_BP=471nt
ATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGTCCCCAGTGGGCCGCCATGTTGTCGGA
GTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGGACTCTTTCAGCCCCCACCTGAAACAT
CACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAGCGCAGCCACAACCAGCTGCAAATCAG
GCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCCAGGACGACGCTATGGTGGACTACTTC
TTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATAGCAAACATCGATGGCCTACTGGGGAT
AACATTCATGCAGAACATCAGGCCCAGCGCTGGCGCAGTGAGAACTTCGAGAGACCCGTGGACCTGGAGGGCTCTGGGGATGATGACTCC
TTTCCCGATGATGAACTGGATGACCTCTACTCGGGGTCGGGCTCGGGCTGTAAGTACCCCCCTCCCTACCTCTGCCTGGGGGCAGTGACC
AGTCTGTATCCAGCCTCAACTCTGAGAAGCCCACGGGGGGCTTGCTTCAGTGAGGCAGGGGGCATTCACTGCCTGGGTCAGGCAAGTTCT
TCTTGCTCTGGATCCCCAGAACAAGAAGGGCAGAACATCCTTCTGGGGATAGAACAAGACCTGGGAGGACCTCAGGGCCCAGAATGTCCA
GGTCTCCAGGGTCCCACGTCTGCATCTTTGTGTGTGCTATGTGGCTTTCTCTGCAGACCTTGCTTGGTTCCGGTGGTCCCGTCAGGTGCA
ATAAGCTGTGGCCAATGGTGGGGTTAGGGCAGTGATGACACAGGGCAGGTGCTTCAAGTGGTGCCTGGGATGGCCCCGCCCTGGGGAAGG
GGAGCCAGGTCAGCTGGGTCTAGCAGAATCTCGGGAGAGAAGGGCACCGCGAACCCCACTCTGCCATGTAGCAACTGTGTGCCCCTCGGT
GCTCCCCCTCCCTGAATCCCTGTATTTTCACCTGTGGATGGTGAGAAATACGACTTCTTCTCAGTGCCTCTAGGAGGGTTTGGGATAGGA
AGCTGGGGTCTGGCACAGAGGAGGAGCTCTCAAAATGGTAGCAAAAAGAAGGCAGCTGAGACTGGGCCCAGTGAGGGCACGGGCTGGCAT
CTGAGGAGATGGTACGGGGTCTGCACGCCACAGAGCTGGCTCCCCACAGCCCTCGCCTCTGGTCTCCCCTCCTTAGCCAAGTCCTTTGAG
CCTCTTTCAAATTAATCTTTGTAAAACCCGTTTATATTGGGTCACATCTCTATTCGCAAAGTTCCCTGGCTCCCCTCCCTCCTGCCTGGT
TCCGAGCCCAGGAGCTGGCTGTGGCTTCTCCCTCCCCCATCCCCTACTCCCCATCTCATTTCCTCCCAAGTTCCTTCACTGTCCCGGCTT
TGCGTCAGCCAGATTGCTCAAGCAGTTCCCCTGCCTCAAGGGCTTCTTTTCCCTTTTACCCTCCGCCTCTGCCTCTGGGGGAAGCCCTTA
GTGTACCACCCCTGCCTTGAGCTTGTGGTAGGGGTGCCTTTGGGGTCTGACTCTTCCCAGAATGCCACTCCTGTGTTCCCCTGCAAGCCC
CAGCAAGTTTTGCAGCCAGTAGCGCCTCAGTTGCTGCTGCCTGGATTCAACCTCATAGAAACTGTAGGCTGGGTGGGCAGGAATAGTCAA
GGAAGGCTTCCCGGGAGAGGCGGCCCCCAGAATTTTTGACTTGGCAGAGAGAAGTTGGGGAACATCAGCAACTGACCACCTTTAGCTGGG
CTGTGCCTTCCTCCTTTCTCTCATCTTTTCTGGGAAAATTGGGTAAAGAGAGGGGGTTGGGAGACCTAATCTTGATGGCCATTGCTTACC
TGGGATCCTCATGCCCCTCACAACCACCCAGCTCCCTAGCTCTCTCCCTCTCCCCCACCCCCTCAGACTTCGAGCAGGAGTCGGGCATTG
AGACAGCCATGCGCTTCAGCCCAGATGTAGCCCTGGCGGTGTCCACCACACCTGCGGTGCTGCCCACCACGAACATCCAGCCTGTGGGCA
CACCATTTGAAGAGCTCCCCTCTGAGCGCCCCACCCTGGAGCCAGCCACCAGCCCCCTGGTGGTGACAGAAGTCCCGGAAGAGCCCAGCC
AGAGAGCCACCACCGTCTCCACTACCATGGCTACCACTGCTGCCACAAGCACAGGGGACCCGACTGTGGCCACAGTGCCTGCCACAGTGG
CCACCGCCACCCCCAGCACCCCTGCAGCACCCCCTTTTACGGCCACCACTGCTGTTATAAGGACCACTGGCGTACGGAGGCTTCTGCCTC
TCCCACTGACCACAGTGGCTACGGCACGGGCCACTACCCCCGAGGCGCCCTCCCCGCCCACCACGGCGGCTGTCTTGGACACCGAGGCCC
CAACACCCAGGCTGGTCAGCACAGCTACCTCCCGGCCAAGAGCCCTTCCCAGGCCGGCCACCACCCAGGAGCCTGACATCCCTGAGAGGA
GCACCCTGCCCCTGGGGACCACTGCCCCTGGACCCACAGAGGTGGCTCAGACCCCAACTCCAGAGACCTTCCTGACCACAATCCGGGATG
AGCCAGAGGTTCCGGTGAGTGGGGGGCCCAGTGGAGACTTCGAGCTGCCAGAAGAAGAGACCACACAACCAGACACAGCCAATGAGGTGG
TAGCTGTGGGAGGGGCTGCGGCCAAGGCATCATCTCCACCTGGGACACTGCCCAAGGGTGCCCGCCCGGGCCCTGGCCTCCTGGACAATG
CCATCGACTCGGGCAGCTCAGCTGCTCAGCTGCCTCAGAAGAGTATCCTGGAGCGGAAGGAGGTGCTCGTAGCTGTGATTGTGGGCGGGG
TGGTGGGCGCCCTCTTTGCTGCCTTCTTGGTCACACTGCTCATCTATCGTATGAAGAAAAAGGATGAGGGCAGCTACACGCTGGAGGAAC
CCAAGCAGGCGAGCGTCACATACCAGAAGCCTGACAAGCAGGAGGAGTTCTATGCCTAGTGGAGCCACAGTGCCTCCCTGCAGCCTCAAC
ACCACCCTGCTGTCCAGTCCCCAGCCTGGCCCCACCAGCCCAAGCCTGGGACTGGGCCTGGAACCTGGCCCCAGTTCTTCTCTGCCCTCT
CTCCCAAGGTCTGCCCAGGCTGCCAGCCTCACACAGATCTTCCCCGAGGAAGAGGGGCTGCTGCCATCTGCCCCAGACTGTGCCCTTACG
AGCTCATCTCTTGTTCCCCTCATCCCTGCCACCAGTCTGGGGCTTCAGGACCTCATGTCAGATGGATGGGAGGAAGAAAGCTCCTGATTG
GCTGGTGGTGGAAGAAAGGGTGGGGCTTGAGATGAGCCTGAGCCCTGACTTGGCACCCACAGTGCTCACTGAGATCTCCTTTTTGGGGCA
GAGAGGCACTCAGGCTGGTTTCCAGGACAAACATTTGGTAAACACAGCCCTTGAAATCATCTAGACACTGCAACCTCTTGCTCGTATCCC
AGGGCCTCTCTCTAGCTGGGTGAGAGGGTGTCCCTTGTCACCAGCCTGTTTTGTCCTGGTCTCTCTGGGGTTGTTGAATCTCTCCTCTTG
CCTGCCAAGTACACATGTACCCAGACTTCATTTCTTTCTGCATCTTCCCCCAAGAAACAGCTTCCTGAGGGTGCTGGGGCAGCCACTGGT
GAGGAGGGGCTGCTCTGATGTCCCTCCTATGAGGGGACTCTGCACAGACACCATTGCCCACACTATCACCATATTTTCACTCAGTCACAC
ACAAGACAAAAGCATGCAATGACAAAACCATACGCAATCCTGACCGCCCAGCCAATCAAGACATATCACAGAACACACGCGTCCTTCCAA
GAATGTTTATCCTCATGCATCACTTACACACCCCCAGACACGTACTGCAATGCAAGTCACTAGTCATGGTCACATGACAGTGACAGTGTG
GCCTCCTCCTACCCCAAATACACCCACACTCTGGCACCACACACATTGTCTCCAGCTTTCAGGCTTACTGGGGAGGGTGGAATCGAGCCA
GAACAATCAGCCCATATTGGGTCCCCCTAAGTTGCCCCGTCATACTCAGTCCCATGCCATGGTGCCCACACCAACCATGCAGCCGCCAAC
CCCAGCCAGTGTCAGACACAATCCCATGTGGATGCACAGTCTCACTCCACATGACCTGCTCTCAATGCTGGAGGGAAACAGGCAGGCCCT
TGCCTTTCTCGGAAAAAGTGTGGGGCCACAGCCCTTTTAGGGCATTGCATGCAGGTGGGCCTGGCTTCACCCCTACCTGCTTCCTCCCCA
CCGCAGCTGGCAGAGGGGGAGGTTTGGGGCCAGACCCCCACTAGCTGGGAGCCTGGGGGCTCCTCTAAGGCTGAGGAAGGAAATTTGGCC
CCAGGTTGTTGGGGGGTCTTGGGTCTCCCAGGACGGAAGGCCCAGGGCAGGGAGGGGGCATGTGGTTGGGCTCCTTTATCTCCCTGTGTC
CCCTTCCTGCTTTGAGCTAGGGGGCTGACTCTGCCTCCCAGGACACAAGTCTCCAAAGTGCCTGTGAGGGCGGGCCCTCCGCACCCTCTG
CCCTCTGCCTGGCAGGCCAACCTCAGCCCACCTGCCCAGAGGCCCTCCCTGTGGACACCCCCTCACCTATTTGGCCAAACAATTCTGGCT
GCAGCTTCAGGGGCCATGGCTGGAAGCAGCCCCTGCAGATCCCTCAGGCCCCGAGGTCAGGGTTTGAGGGATGAGACCAGGTGATAGTGG
GGGAGGGGTTACTTCCTTTGTTACCTAGCAAGTAGGGCTATTTCCATCGGTATTTTAAATGTGGGGTCACAGATCTTTTGGGGAGGGTGT
GCTTGGCAGGGGGCCTCTTGGAGCCAAAGGGATGTGGTGTGAGTTGCGATTGGCTGGCACTCACACCCCCACCCCTCACCCACATCCCAG
ATTCAAGTCAGGAAGGCAGGTTTTATTTCAGGGCCCTTTTCAAGATGCCCTGGCAGCAGATTTCTGCAGGATGAGGGGTAGCGGTGTGTA
GGCAGTGAGGGGGAGGTTCCAGGGGCTGTCCCACAGCCTGTCTTTTCCAGGCTGGGCTCCATCTTCCAGTCCCAAAACCCTCCTTCACAG
GGCCCAGAGGCTTGTGAGGAAGCCAGGTGGACCCAGCCTTAGAAGAGTGGGCATGGGGGGCCCCTGATATCTGGAGGGGGCGGGTTGGCC
TCAGTCATCTTTGGAGCAGAAGGGCTGGGTCCTGGGGCCACAGACCACAAGGCTCAGCCTCCCTACCCTGCTCCCTGGGGTGCTGCTGTC
TTGGAGAGCACAGCTCTGGTGAGACGGCCTGGGCAGGCCGAGGCTGAGAAACCAGGGAGGATAGAGGAGAAAAGGGCTTGGGCCCCCAGC
CCCAGAAGATGCTGGACCCCAGGTGGGAGACCCAACAGTGGGTGCAGTTTCTCAGTAGGGCTGGAGCCAATGGTGGGGGTGGCCCCGGCA
GGCCTGGCTCCTCACATCCCAGGGGTTGGCTTCTGATTTGGGGCTTGGGCTCCAGGCACTGGCTTCTCTTCTCTGTGTCCTTAGCATTTG
AGAGAAGAGGCCAGGGGCCTTGTTCATGGATCCCTGGACCCAAGGCAGATGTCCAGGCTTTATCCTCCTGAGGATGAGGAGTCTGACCAG
CCCAAATCTGCCCTGGCCGGCCTGACCGGGGCAAGGCAGTCCAAGAGAGTTCAGTGAGGACCAGCTAGGCTCTCCCAGGTGCAATGTGGG
TGCAGGGCCCTCATGTCCCCCTACCCCTGCCTGTGATGGAGTGTTCTGAGGGGCTTTGGCATTTGCTGGAAGCACAGGGAGTTCCAAATG
AGAGGGAGCTTCTGTGGCTTGAGAGCCTCTGGGGCCTTGGCTGCCAGAGCACGAGGCAGGCCAGGACCTGGAGAGCCCAGACCCTGTCTC
CAGGAGGCCAGGAGGCCAGATGGGGGCCTTGCCTGAAAGACTGGTCCCCTTGATCGCTGGAGGCATGTGGGTGGCAACCAGGGCTGGGCA
GGGCTTAGGGTGTGTGGGCCAAACCCCCCTGGGGTTGGCAAAGCCGCCTGTCAGGCCTCCTGGTGGGGGCCCCTGGACACAGGGAGCAGA
CCCTCTGCCTCATGGGGTAGGAGTGGCTGCCTCCTGTGTTCTCTGGATTTCTTCTCCCAACAACTACAACCCTGGACTTGCCTCCCCAGG
CCTCTTGCCTGTAAATAGAAGCCCGCAAACTGTACAGATTTACAGAGGCATCGAGACTGGGCCCTGGGAGTTGCCATCTGAGAGCCGATG
GCCCCAGCATCCCCCAGGTGCCTGCCTGGCACCACAGTGACCCTGGCCTCAGCGTGGCAAATGCATGTAAATATTTTTCGTAGGCAGCGT
GGCTCCAGAGAGCCCCCTGAAGACAGTGTCCCTCCCTCCTGTGAGTCCTTTCTCCTGTACAGAACCTGCCTGGGGTGGGTGGGGGTCTGC
CATTCCCTCCCCCAGGCCTTCCCTGCCCCTTCTCTCCCCTGTAACCTGTTTATTAACCATACCTGTCCTGAGTTCATGGCCAAAACCTTA
AATAAGAAAAACAAAAGAAAAAGACAGTGGAAAAAAGAGACCAAGGCGCCTGCCCCACTGCGGGTACTCTCCTGTTCCAGCCTTGTGAAG
GAACTGGTTTTGTTTTTGTTTTTTTTTTTTTTTTTTTTTTTTTGTTTGTTTGTTTTTTTAACACTTCCTGTGCTGTGCCCATTTATAAGA

>In-frame_ENST00000373742_ENST00000336798_TCGA-A2-A25F-01A_PUM1_chr1_31532051_-_SDC3_chr1_31351587_length(amino acids)=427AA_start in transcript=1835_stop in transcript=3118
MTWQREVGEHQQLTTFSWAVPSSFLSSFLGKLGKERGLGDLILMAIAYLGSSCPSQPPSSLALSLSPTPSDFEQESGIETAMRFSPDVAL
AVSTTPAVLPTTNIQPVGTPFEELPSERPTLEPATSPLVVTEVPEEPSQRATTVSTTMATTAATSTGDPTVATVPATVATATPSTPAAPP
FTATTAVIRTTGVRRLLPLPLTTVATARATTPEAPSPPTTAAVLDTEAPTPRLVSTATSRPRALPRPATTQEPDIPERSTLPLGTTAPGP
TEVAQTPTPETFLTTIRDEPEVPVSGGPSGDFELPEEETTQPDTANEVVAVGGAAAKASSPPGTLPKGARPGPGLLDNAIDSGSSAAQLP

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>In-frame_ENST00000373742_ENST00000339394_TCGA-A2-A25F-01A_PUM1_chr1_31532051_-_SDC3_chr1_31351587_length(transcript)=1738nt_BP=471nt
ATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGTCCCCAGTGGGCCGCCATGTTGTCGGA
GTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGGACTCTTTCAGCCCCCACCTGAAACAT
CACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAGCGCAGCCACAACCAGCTGCAAATCAG
GCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCCAGGACGACGCTATGGTGGACTACTTC
TTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATAGCAAACATCGATGGCCTACTGGGGAT
AACATTCATGCAGAACATCAGGCCCAGCGCTGGCGCAGTGAGAACTTCGAGAGACCCGTGGACCTGGAGGGCTCTGGGGATGATGACTCC
TTTCCCGATGATGAACTGGATGACCTCTACTCGGGGTCGGGCTCGGGCTACTTCGAGCAGGAGTCGGGCATTGAGACAGCCATGCGCTTC
AGCCCAGATGTAGCCCTGGCGGTGTCCACCACACCTGCGGTGCTGCCCACCACGAACATCCAGCCTGTGGGCACACCATTTGAAGAGCTC
CCCTCTGAGCGCCCCACCCTGGAGCCAGCCACCAGCCCCCTGGTGGTGACAGAAGTCCCGGAAGAGCCCAGCCAGAGAGCCACCACCGTC
TCCACTACCATGGCTACCACTGCTGCCACAAGCACAGGGGACCCGACTGTGGCCACAGTGCCTGCCACAGTGGCCACCGCCACCCCCAGC
ACCCCTGCAGCACCCCCTTTTACGGCCACCACTGCTGTTATAAGGACCACTGGCGTACGGAGGCTTCTGCCTCTCCCACTGACCACAGTG
GCTACGGCACGGGCCACTACCCCCGAGGCGCCCTCCCCGCCCACCACGGCGGCTGTCTTGGACACCGAGGCCCCAACACCCAGGCTGGTC
AGCACAGCTACCTCCCGGCCAAGAGCCCTTCCCAGGCCGGCCACCACCCAGGAGCCTGACATCCCTGAGAGGAGCACCCTGCCCCTGGGG
ACCACTGCCCCTGGACCCACAGAGGTGGCTCAGACCCCAACTCCAGAGACCTTCCTGACCACAATCCGGGATGAGCCAGAGGTTCCGGTG
AGTGGGGGGCCCAGTGGAGACTTCGAGCTGCCAGAAGAAGAGACCACACAACCAGACACAGCCAATGAGGTGGTAGCTGTGGGAGGGGCT
GCGGCCAAGGCATCATCTCCACCTGGGACACTGCCCAAGGGTGCCCGCCCGGGCCCTGGCCTCCTGGACAATGCCATCGACTCGGGCAGC
TCAGCTGCTCAGCTGCCTCAGAAGAGTATCCTGGAGCGGAAGGAGGTGCTCGTAGCTGTGATTGTGGGCGGGGTGGTGGGCGCCCTCTTT
GCTGCCTTCTTGGTCACACTGCTCATCTATCGTATGAAGAAAAAGGATGAGGGCAGCTACACGCTGGAGGAACCCAAGCAGGCGAGCGTC
ACATACCAGAAGCCTGACAAGCAGGAGGAGTTCTATGCCTAGTGGAGCCACAGTGCCTCCCTGCAGCCTCAACACCACCCTGCTGTCCAG

>In-frame_ENST00000373742_ENST00000339394_TCGA-A2-A25F-01A_PUM1_chr1_31532051_-_SDC3_chr1_31351587_length(amino acids)=553AA_start in transcript=0_stop in transcript=1661
MPLPPPGPGPEPIPGCTAPTQSPVGRHVVGVKGVGGMSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGSQAQPQPAANQ
ALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTGDNIHAEHQAQRWRSENFERPVDLEGSGDDDS
FPDDELDDLYSGSGSGYFEQESGIETAMRFSPDVALAVSTTPAVLPTTNIQPVGTPFEELPSERPTLEPATSPLVVTEVPEEPSQRATTV
STTMATTAATSTGDPTVATVPATVATATPSTPAAPPFTATTAVIRTTGVRRLLPLPLTTVATARATTPEAPSPPTTAAVLDTEAPTPRLV
STATSRPRALPRPATTQEPDIPERSTLPLGTTAPGPTEVAQTPTPETFLTTIRDEPEVPVSGGPSGDFELPEEETTQPDTANEVVAVGGA
AAKASSPPGTLPKGARPGPGLLDNAIDSGSSAAQLPQKSILERKEVLVAVIVGGVVGALFAAFLVTLLIYRMKKKDEGSYTLEEPKQASV

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Fusion Gene PPI Analysis for PUM1-SDC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for PUM1-SDC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for PUM1-SDC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePUM1C0004134Ataxia1GENOMICS_ENGLAND
HgenePUM1C0010417Cryptorchidism1GENOMICS_ENGLAND
HgenePUM1C0019193Hepatitis, Toxic1CTD_human
HgenePUM1C0036572Seizures1GENOMICS_ENGLAND
HgenePUM1C0557874Global developmental delay1GENOMICS_ENGLAND
HgenePUM1C0860207Drug-Induced Liver Disease1CTD_human
HgenePUM1C1262760Hepatitis, Drug-Induced1CTD_human
HgenePUM1C3658290Drug-Induced Acute Liver Injury1CTD_human
HgenePUM1C3714756Intellectual Disability1GENOMICS_ENGLAND
HgenePUM1C4025871Abnormality of the face1GENOMICS_ENGLAND
HgenePUM1C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgenePUM1C4279912Chemically-Induced Liver Toxicity1CTD_human
HgenePUM1C4693672SPINOCEREBELLAR ATAXIA 471GENOMICS_ENGLAND;UNIPROT