FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:PUM1-SDCCAG8 (FusionGDB2 ID:70250)

Fusion Gene Summary for PUM1-SDCCAG8

check button Fusion gene summary
Fusion gene informationFusion gene name: PUM1-SDCCAG8
Fusion gene ID: 70250
HgeneTgene
Gene symbol

PUM1

SDCCAG8

Gene ID

9698

10806

Gene namepumilio RNA binding family member 1SHH signaling and ciliogenesis regulator SDCCAG8
SynonymsHSPUM|PUMH|PUMH1|PUML1|SCA47BBS16|CCCAP|CCCAP SLSN7|HSPC085|NPHP10|NY-CO-8|SLSN7|hCCCAP
Cytomap

1p35.2

1q43-q44

Type of geneprotein-codingprotein-coding
Descriptionpumilio homolog 1pumilio-1serologically defined colon cancer antigen 8Bardet-Biedl syndrome 16antigen NY-CO-8centrosomal colon cancer autoantigen proteinnephrocystin 10
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000424085, ENST00000257075, 
ENST00000373747, ENST00000426105, 
ENST00000440538, ENST00000373741, 
ENST00000423018, ENST00000373742, 
ENST00000490546, 		ENST00000355875, 
ENST00000366541, ENST00000343783, 
ENST00000391846, ENST00000496361, 
Fusion gene scores* DoF score38 X 31 X 15=1767022 X 19 X 10=4180
# samples 5626
** MAII scorelog2(56/17670*10)=-4.97973140249401
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/4180*10)=-4.00691941393979
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PUM1 [Title/Abstract] AND SDCCAG8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointPUM1(31501643)-SDCCAG8(243493842), # samples:3
Anticipated loss of major functional domain due to fusion event.PUM1-SDCCAG8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePUM1

GO:0010608

posttranscriptional regulation of gene expression

25100735

HgenePUM1

GO:0043488

regulation of mRNA stability

26724866

HgenePUM1

GO:0051726

regulation of cell cycle

20818387

HgenePUM1

GO:0051983

regulation of chromosome segregation

26724866

HgenePUM1

GO:1900246

positive regulation of RIG-I signaling pathway

25340845

HgenePUM1

GO:2000637

positive regulation of gene silencing by miRNA

20818387|22345517


check buttonFusion gene breakpoints across PUM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SDCCAG8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-5527-01APUM1chr1

31501643

-SDCCAG8chr1

243493842

+
ChimerDB4PRADTCGA-EJ-5527PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
ChimerDB4PRADTCGA-EJ-5527-01APUM1chr1

31501643

-SDCCAG8chr1

243493842

+


Top

Fusion Gene ORF analysis for PUM1-SDCCAG8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000424085ENST00000355875PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000424085ENST00000366541PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000424085ENST00000343783PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000424085ENST00000391846PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000424085ENST00000496361PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000257075ENST00000355875PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000257075ENST00000366541PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000257075ENST00000343783PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000257075ENST00000391846PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000257075ENST00000496361PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000373747ENST00000355875PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000373747ENST00000366541PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000373747ENST00000343783PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000373747ENST00000391846PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000373747ENST00000496361PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000426105ENST00000355875PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000426105ENST00000366541PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000426105ENST00000343783PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000426105ENST00000391846PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000426105ENST00000496361PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000440538ENST00000355875PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000440538ENST00000366541PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000440538ENST00000343783PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000440538ENST00000391846PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000440538ENST00000496361PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
In-frameENST00000373741ENST00000355875PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
In-frameENST00000373741ENST00000366541PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
In-frameENST00000373741ENST00000343783PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000373741ENST00000391846PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000373741ENST00000496361PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000423018ENST00000355875PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000423018ENST00000366541PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
Frame-shiftENST00000423018ENST00000343783PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000423018ENST00000391846PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000423018ENST00000496361PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
In-frameENST00000373742ENST00000355875PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
In-frameENST00000373742ENST00000366541PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
In-frameENST00000373742ENST00000343783PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000373742ENST00000391846PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
5CDS-intronENST00000373742ENST00000496361PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
intron-3CDSENST00000490546ENST00000355875PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
intron-3CDSENST00000490546ENST00000366541PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
intron-3CDSENST00000490546ENST00000343783PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
intron-intronENST00000490546ENST00000391846PUM1chr1

31501643

-SDCCAG8chr1

243493842

+
intron-intronENST00000490546ENST00000496361PUM1chr1

31501643

-SDCCAG8chr1

243493842

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373741PUM1chr131501643-ENST00000355875SDCCAG8chr1243493842+21217461131819568
ENST00000373741PUM1chr131501643-ENST00000366541SDCCAG8chr1243493842+21277461131819568
ENST00000373741PUM1chr131501643-ENST00000343783SDCCAG8chr1243493842+21257461131819568
ENST00000373742PUM1chr131501643-ENST00000355875SDCCAG8chr1243493842+191554001613537
ENST00000373742PUM1chr131501643-ENST00000366541SDCCAG8chr1243493842+192154001613537
ENST00000373742PUM1chr131501643-ENST00000343783SDCCAG8chr1243493842+191954001613537

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373741ENST00000355875PUM1chr131501643-SDCCAG8chr1243493842+0.0101372180.9898628
ENST00000373741ENST00000366541PUM1chr131501643-SDCCAG8chr1243493842+0.0097344450.99026555
ENST00000373741ENST00000343783PUM1chr131501643-SDCCAG8chr1243493842+0.0097740080.990226
ENST00000373742ENST00000355875PUM1chr131501643-SDCCAG8chr1243493842+0.0111457060.9888543
ENST00000373742ENST00000366541PUM1chr131501643-SDCCAG8chr1243493842+0.0106894520.9893106
ENST00000373742ENST00000343783PUM1chr131501643-SDCCAG8chr1243493842+0.0106985720.9893014

Top

Fusion Genomic Features for PUM1-SDCCAG8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
PUM1chr131501642-SDCCAG8chr1243493841+2.17E-111
PUM1chr131501642-SDCCAG8chr1243493841+2.17E-111
PUM1chr131501642-SDCCAG8chr1243493841+2.17E-111
PUM1chr131501642-SDCCAG8chr1243493841+2.17E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for PUM1-SDCCAG8


check button Go to

FGviewer for the breakpoints of chr1:31501643-chr1:243493842

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSDCCAG8chr1:31501643chr1:243493842ENST00000391846010129_1750361.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr1:31501643chr1:243493842ENST00000391846010223_2730361.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr1:31501643chr1:243493842ENST00000391846010348_7070361.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr1:31501643chr1:243493842ENST00000366541818534_692356.0714.0Compositional biasNote=Gln-rich
TgeneSDCCAG8chr1:31501643chr1:243493842ENST00000391846010534_6920361.0Compositional biasNote=Gln-rich
TgeneSDCCAG8chr1:31501643chr1:243493842ENST00000391846010216_7130361.0RegionSufficient for homodimerization

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePUM1chr1:31501643chr1:243493842ENST00000257075-322393_613144.01187.0Compositional biasNote=Ala-rich
HgenePUM1chr1:31501643chr1:243493842ENST00000257075-322475_523144.01187.0Compositional biasNote=Gln-rich
HgenePUM1chr1:31501643chr1:243493842ENST00000257075-322642_815144.01187.0Compositional biasNote=Ser-rich
HgenePUM1chr1:31501643chr1:243493842ENST00000426105-322393_613144.01189.0Compositional biasNote=Ala-rich
HgenePUM1chr1:31501643chr1:243493842ENST00000426105-322475_523144.01189.0Compositional biasNote=Gln-rich
HgenePUM1chr1:31501643chr1:243493842ENST00000426105-322642_815144.01189.0Compositional biasNote=Ser-rich
HgenePUM1chr1:31501643chr1:243493842ENST00000440538-322393_613144.01163.0Compositional biasNote=Ala-rich
HgenePUM1chr1:31501643chr1:243493842ENST00000440538-322475_523144.01163.0Compositional biasNote=Gln-rich
HgenePUM1chr1:31501643chr1:243493842ENST00000440538-322642_815144.01163.0Compositional biasNote=Ser-rich
HgenePUM1chr1:31501643chr1:243493842ENST00000257075-322828_1168144.01187.0DomainPUM-HD
HgenePUM1chr1:31501643chr1:243493842ENST00000426105-322828_1168144.01189.0DomainPUM-HD
HgenePUM1chr1:31501643chr1:243493842ENST00000440538-322828_1168144.01163.0DomainPUM-HD
HgenePUM1chr1:31501643chr1:243493842ENST00000257075-3221028_1063144.01187.0RepeatPumilio 6
HgenePUM1chr1:31501643chr1:243493842ENST00000257075-3221064_1099144.01187.0RepeatPumilio 7
HgenePUM1chr1:31501643chr1:243493842ENST00000257075-3221103_1142144.01187.0RepeatPumilio 8
HgenePUM1chr1:31501643chr1:243493842ENST00000257075-322848_883144.01187.0RepeatPumilio 1
HgenePUM1chr1:31501643chr1:243493842ENST00000257075-322884_919144.01187.0RepeatPumilio 2
HgenePUM1chr1:31501643chr1:243493842ENST00000257075-322920_955144.01187.0RepeatPumilio 3
HgenePUM1chr1:31501643chr1:243493842ENST00000257075-322956_991144.01187.0RepeatPumilio 4
HgenePUM1chr1:31501643chr1:243493842ENST00000257075-322992_1027144.01187.0RepeatPumilio 5
HgenePUM1chr1:31501643chr1:243493842ENST00000426105-3221028_1063144.01189.0RepeatPumilio 6
HgenePUM1chr1:31501643chr1:243493842ENST00000426105-3221064_1099144.01189.0RepeatPumilio 7
HgenePUM1chr1:31501643chr1:243493842ENST00000426105-3221103_1142144.01189.0RepeatPumilio 8
HgenePUM1chr1:31501643chr1:243493842ENST00000426105-322848_883144.01189.0RepeatPumilio 1
HgenePUM1chr1:31501643chr1:243493842ENST00000426105-322884_919144.01189.0RepeatPumilio 2
HgenePUM1chr1:31501643chr1:243493842ENST00000426105-322920_955144.01189.0RepeatPumilio 3
HgenePUM1chr1:31501643chr1:243493842ENST00000426105-322956_991144.01189.0RepeatPumilio 4
HgenePUM1chr1:31501643chr1:243493842ENST00000426105-322992_1027144.01189.0RepeatPumilio 5
HgenePUM1chr1:31501643chr1:243493842ENST00000440538-3221028_1063144.01163.0RepeatPumilio 6
HgenePUM1chr1:31501643chr1:243493842ENST00000440538-3221064_1099144.01163.0RepeatPumilio 7
HgenePUM1chr1:31501643chr1:243493842ENST00000440538-3221103_1142144.01163.0RepeatPumilio 8
HgenePUM1chr1:31501643chr1:243493842ENST00000440538-322848_883144.01163.0RepeatPumilio 1
HgenePUM1chr1:31501643chr1:243493842ENST00000440538-322884_919144.01163.0RepeatPumilio 2
HgenePUM1chr1:31501643chr1:243493842ENST00000440538-322920_955144.01163.0RepeatPumilio 3
HgenePUM1chr1:31501643chr1:243493842ENST00000440538-322956_991144.01163.0RepeatPumilio 4
HgenePUM1chr1:31501643chr1:243493842ENST00000440538-322992_1027144.01163.0RepeatPumilio 5
TgeneSDCCAG8chr1:31501643chr1:243493842ENST00000366541818129_175356.0714.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr1:31501643chr1:243493842ENST00000366541818223_273356.0714.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr1:31501643chr1:243493842ENST00000366541818348_707356.0714.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr1:31501643chr1:243493842ENST00000366541818216_713356.0714.0RegionSufficient for homodimerization


Top

Fusion Gene Sequence for PUM1-SDCCAG8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000373741_ENST00000355875_TCGA-EJ-5527-01A_PUM1_chr1_31501643_-_SDCCAG8_chr1_243493842_length(transcript)=2121nt_BP=746nt
AACCCCGCGTGCCCAGCTCCAGGCCGTGTTCTCCCAGGTGCGGGCCGGCGGGACCCCGCCTTCGGCCCTGGCGGCGCGCGCTCGCCTAGC
GGGCGGGCACTCGCGCGCAGCGTTTGTGTTGCCTGCGAGTTTCCCGAGTTCACACAGGCCCTGGGTTGGCATGGCAACCAGGCAACCTGT
TCCAGAGCCGCCAGCCTTCTCCGCACATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGT
CCCCAGTGGGCCGCCATGTTGTCGGAGTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGG
ACTCTTTCAGCCCCCACCTGAAACATCACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAG
CGCAGCCACAACCAGCTGCAAATCAGGCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCC
AGGACGACGCTATGGTGGACTACTTCTTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATA
GCAAACATCGATGGCCTACTGGGGATAACATTCATGCAGAACATCAGGTGCGTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTG
CTCTGGAGGGAAGAGCGATGGGAGAGGCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAG
AACTTGCATCTCAGCAAGAGAAAAGGGCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGA
TGTTGATCTTGTCTCAGAATATTGCCCAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGG
AAATTCAAAGCCAGCTGGCTTCTCGGGAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGA
AGGATGAGGCAGAAAAGGAGCACAGAGAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAA
TAGAACTGGATGAAAGCAAACAACACTTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGC
TGGGCGAATCTGAGCACCAACTGCACCTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCC
TTCAGGCCCAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGT
TGCTGACCTCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCA
GATCTGAAATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAAC
AGTGTGTCCAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGG
TGCAGCTCCTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCA
TGCCACAATCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATA
TGCCACAACGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACG
CAGTCGGGCTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCT

>In-frame_ENST00000373741_ENST00000355875_TCGA-EJ-5527-01A_PUM1_chr1_31501643_-_SDCCAG8_chr1_243493842_length(amino acids)=568AA_start in transcript=113_stop in transcript=1819
MCCLRVSRVHTGPGLAWQPGNLFQSRQPSPHMPLPPPGPGPEPIPGCTAPTQSPVGRHVVGVKGVGGMSVACVLKRKAVLWQDSFSPHLK
HHPQEPANPNMPVVLTSGTGSQAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTG
DNIHAEHQVRSMDELNHDFQALALEGRAMGEALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNI
AQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQ
HLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTF
LTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQN

--------------------------------------------------------------
>In-frame_ENST00000373741_ENST00000366541_TCGA-EJ-5527-01A_PUM1_chr1_31501643_-_SDCCAG8_chr1_243493842_length(transcript)=2127nt_BP=746nt
AACCCCGCGTGCCCAGCTCCAGGCCGTGTTCTCCCAGGTGCGGGCCGGCGGGACCCCGCCTTCGGCCCTGGCGGCGCGCGCTCGCCTAGC
GGGCGGGCACTCGCGCGCAGCGTTTGTGTTGCCTGCGAGTTTCCCGAGTTCACACAGGCCCTGGGTTGGCATGGCAACCAGGCAACCTGT
TCCAGAGCCGCCAGCCTTCTCCGCACATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGT
CCCCAGTGGGCCGCCATGTTGTCGGAGTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGG
ACTCTTTCAGCCCCCACCTGAAACATCACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAG
CGCAGCCACAACCAGCTGCAAATCAGGCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCC
AGGACGACGCTATGGTGGACTACTTCTTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATA
GCAAACATCGATGGCCTACTGGGGATAACATTCATGCAGAACATCAGGTGCGTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTG
CTCTGGAGGGAAGAGCGATGGGAGAGGCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAG
AACTTGCATCTCAGCAAGAGAAAAGGGCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGA
TGTTGATCTTGTCTCAGAATATTGCCCAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGG
AAATTCAAAGCCAGCTGGCTTCTCGGGAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGA
AGGATGAGGCAGAAAAGGAGCACAGAGAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAA
TAGAACTGGATGAAAGCAAACAACACTTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGC
TGGGCGAATCTGAGCACCAACTGCACCTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCC
TTCAGGCCCAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGT
TGCTGACCTCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCA
GATCTGAAATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAAC
AGTGTGTCCAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGG
TGCAGCTCCTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCA
TGCCACAATCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATA
TGCCACAACGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACG
CAGTCGGGCTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCT

>In-frame_ENST00000373741_ENST00000366541_TCGA-EJ-5527-01A_PUM1_chr1_31501643_-_SDCCAG8_chr1_243493842_length(amino acids)=568AA_start in transcript=113_stop in transcript=1819
MCCLRVSRVHTGPGLAWQPGNLFQSRQPSPHMPLPPPGPGPEPIPGCTAPTQSPVGRHVVGVKGVGGMSVACVLKRKAVLWQDSFSPHLK
HHPQEPANPNMPVVLTSGTGSQAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTG
DNIHAEHQVRSMDELNHDFQALALEGRAMGEALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNI
AQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQ
HLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTF
LTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQN

--------------------------------------------------------------
>In-frame_ENST00000373741_ENST00000343783_TCGA-EJ-5527-01A_PUM1_chr1_31501643_-_SDCCAG8_chr1_243493842_length(transcript)=2125nt_BP=746nt
AACCCCGCGTGCCCAGCTCCAGGCCGTGTTCTCCCAGGTGCGGGCCGGCGGGACCCCGCCTTCGGCCCTGGCGGCGCGCGCTCGCCTAGC
GGGCGGGCACTCGCGCGCAGCGTTTGTGTTGCCTGCGAGTTTCCCGAGTTCACACAGGCCCTGGGTTGGCATGGCAACCAGGCAACCTGT
TCCAGAGCCGCCAGCCTTCTCCGCACATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGT
CCCCAGTGGGCCGCCATGTTGTCGGAGTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGG
ACTCTTTCAGCCCCCACCTGAAACATCACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAG
CGCAGCCACAACCAGCTGCAAATCAGGCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCC
AGGACGACGCTATGGTGGACTACTTCTTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATA
GCAAACATCGATGGCCTACTGGGGATAACATTCATGCAGAACATCAGGTGCGTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTG
CTCTGGAGGGAAGAGCGATGGGAGAGGCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAG
AACTTGCATCTCAGCAAGAGAAAAGGGCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGA
TGTTGATCTTGTCTCAGAATATTGCCCAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGG
AAATTCAAAGCCAGCTGGCTTCTCGGGAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGA
AGGATGAGGCAGAAAAGGAGCACAGAGAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAA
TAGAACTGGATGAAAGCAAACAACACTTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGC
TGGGCGAATCTGAGCACCAACTGCACCTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCC
TTCAGGCCCAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGT
TGCTGACCTCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCA
GATCTGAAATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAAC
AGTGTGTCCAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGG
TGCAGCTCCTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCA
TGCCACAATCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATA
TGCCACAACGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACG
CAGTCGGGCTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCT

>In-frame_ENST00000373741_ENST00000343783_TCGA-EJ-5527-01A_PUM1_chr1_31501643_-_SDCCAG8_chr1_243493842_length(amino acids)=568AA_start in transcript=113_stop in transcript=1819
MCCLRVSRVHTGPGLAWQPGNLFQSRQPSPHMPLPPPGPGPEPIPGCTAPTQSPVGRHVVGVKGVGGMSVACVLKRKAVLWQDSFSPHLK
HHPQEPANPNMPVVLTSGTGSQAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTG
DNIHAEHQVRSMDELNHDFQALALEGRAMGEALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNI
AQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQ
HLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTF
LTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQN

--------------------------------------------------------------
>In-frame_ENST00000373742_ENST00000355875_TCGA-EJ-5527-01A_PUM1_chr1_31501643_-_SDCCAG8_chr1_243493842_length(transcript)=1915nt_BP=540nt
ATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGTCCCCAGTGGGCCGCCATGTTGTCGGA
GTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGGACTCTTTCAGCCCCCACCTGAAACAT
CACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAGCGCAGCCACAACCAGCTGCAAATCAG
GCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCCAGGACGACGCTATGGTGGACTACTTC
TTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATAGCAAACATCGATGGCCTACTGGGGAT
AACATTCATGCAGAACATCAGGTGCGTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTGCTCTGGAGGGAAGAGCGATGGGAGAG
GCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGG
GCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCC
CAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGG
GAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGA
GAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACAC
TTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCAC
CTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAG
CTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTG
ACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAA
GAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACAT
GAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAG
CTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAATCTGATTGCTGACCTGGA
TGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAACGCACCACGACCTTCCCA
GGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAGCTGGAGTCTGAC
TCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTCGTATGCTAGGTTATACAT

>In-frame_ENST00000373742_ENST00000355875_TCGA-EJ-5527-01A_PUM1_chr1_31501643_-_SDCCAG8_chr1_243493842_length(amino acids)=537AA_start in transcript=0_stop in transcript=1613
MPLPPPGPGPEPIPGCTAPTQSPVGRHVVGVKGVGGMSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGSQAQPQPAANQ
ALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGE
ALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASR
EMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLH
LTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQ

--------------------------------------------------------------
>In-frame_ENST00000373742_ENST00000366541_TCGA-EJ-5527-01A_PUM1_chr1_31501643_-_SDCCAG8_chr1_243493842_length(transcript)=1921nt_BP=540nt
ATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGTCCCCAGTGGGCCGCCATGTTGTCGGA
GTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGGACTCTTTCAGCCCCCACCTGAAACAT
CACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAGCGCAGCCACAACCAGCTGCAAATCAG
GCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCCAGGACGACGCTATGGTGGACTACTTC
TTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATAGCAAACATCGATGGCCTACTGGGGAT
AACATTCATGCAGAACATCAGGTGCGTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTGCTCTGGAGGGAAGAGCGATGGGAGAG
GCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGG
GCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCC
CAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGG
GAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGA
GAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACAC
TTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCAC
CTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAG
CTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTG
ACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAA
GAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACAT
GAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAG
CTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAATCTGATTGCTGACCTGGA
TGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAACGCACCACGACCTTCCCA
GGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAGCTGGAGTCTGAC
TCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTCGTATGCTAGGTTATACAT

>In-frame_ENST00000373742_ENST00000366541_TCGA-EJ-5527-01A_PUM1_chr1_31501643_-_SDCCAG8_chr1_243493842_length(amino acids)=537AA_start in transcript=0_stop in transcript=1613
MPLPPPGPGPEPIPGCTAPTQSPVGRHVVGVKGVGGMSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGSQAQPQPAANQ
ALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGE
ALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASR
EMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLH
LTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQ

--------------------------------------------------------------
>In-frame_ENST00000373742_ENST00000343783_TCGA-EJ-5527-01A_PUM1_chr1_31501643_-_SDCCAG8_chr1_243493842_length(transcript)=1919nt_BP=540nt
ATGCCGCTGCCACCGCCGGGGCCGGGGCCGGAGCCTATCCCAGGATGCACCGCGCCAACCCAGTCCCCAGTGGGCCGCCATGTTGTCGGA
GTGAAAGGTGTTGGTGGAATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGGACTCTTTCAGCCCCCACCTGAAACAT
CACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCTGGAACAGGGTCGCAAGCGCAGCCACAACCAGCTGCAAATCAG
GCTCTTGCAGCTGGGACTCACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCCAGGACGACGCTATGGTGGACTACTTC
TTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGAGGCGGCTATAATAATAGCAAACATCGATGGCCTACTGGGGAT
AACATTCATGCAGAACATCAGGTGCGTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTGCTCTGGAGGGAAGAGCGATGGGAGAG
GCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGG
GCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCC
CAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGG
GAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGA
GAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACAC
TTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCAC
CTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAG
CTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTG
ACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAA
GAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACAT
GAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAG
CTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAATCTGATTGCTGACCTGGA
TGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAACGCACCACGACCTTCCCA
GGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAGCTGGAGTCTGAC
TCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTCGTATGCTAGGTTATACAT

>In-frame_ENST00000373742_ENST00000343783_TCGA-EJ-5527-01A_PUM1_chr1_31501643_-_SDCCAG8_chr1_243493842_length(amino acids)=537AA_start in transcript=0_stop in transcript=1613
MPLPPPGPGPEPIPGCTAPTQSPVGRHVVGVKGVGGMSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGSQAQPQPAANQ
ALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGE
ALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASR
EMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLH
LTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQ

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for PUM1-SDCCAG8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for PUM1-SDCCAG8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for PUM1-SDCCAG8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePUM1C0004134Ataxia1GENOMICS_ENGLAND
HgenePUM1C0010417Cryptorchidism1GENOMICS_ENGLAND
HgenePUM1C0019193Hepatitis, Toxic1CTD_human
HgenePUM1C0036572Seizures1GENOMICS_ENGLAND
HgenePUM1C0557874Global developmental delay1GENOMICS_ENGLAND
HgenePUM1C0860207Drug-Induced Liver Disease1CTD_human
HgenePUM1C1262760Hepatitis, Drug-Induced1CTD_human
HgenePUM1C3658290Drug-Induced Acute Liver Injury1CTD_human
HgenePUM1C3714756Intellectual Disability1GENOMICS_ENGLAND
HgenePUM1C4025871Abnormality of the face1GENOMICS_ENGLAND
HgenePUM1C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgenePUM1C4279912Chemically-Induced Liver Toxicity1CTD_human
HgenePUM1C4693672SPINOCEREBELLAR ATAXIA 471GENOMICS_ENGLAND;UNIPROT
TgeneSDCCAG8C3150877SENIOR-LOKEN SYNDROME 73GENOMICS_ENGLAND
TgeneSDCCAG8C3889474BARDET-BIEDL SYNDROME 163CTD_human;GENOMICS_ENGLAND
TgeneSDCCAG8C0403553Renal dysplasia and retinal aplasia (disorder)2GENOMICS_ENGLAND;ORPHANET
TgeneSDCCAG8C0752166Bardet-Biedl Syndrome2GENOMICS_ENGLAND;ORPHANET
TgeneSDCCAG8C0022679Cystic kidney1CTD_human
TgeneSDCCAG8C0035309Retinal Diseases1CTD_human
TgeneSDCCAG8C0036341Schizophrenia1PSYGENET
TgeneSDCCAG8C1691228Cystic Kidney Diseases1CTD_human
TgeneSDCCAG8C3714756Intellectual Disability1GENOMICS_ENGLAND