FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:QRICH1-FBXW12 (FusionGDB2 ID:70561)

Fusion Gene Summary for QRICH1-FBXW12

check button Fusion gene summary
Fusion gene informationFusion gene name: QRICH1-FBXW12
Fusion gene ID: 70561
HgeneTgene
Gene symbol

QRICH1

FBXW12

Gene ID

54870

285231

Gene nameglutamine rich 1F-box and WD repeat domain containing 12
SynonymsAB-DIP|VERBRASFBW12|FBXO12|FBXO35
Cytomap

3p21.31

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionglutamine-rich protein 1F-box/WD repeat-containing protein 12F-box and WD-40 domain protein 12F-box and WD-40 domain-containing protein 12F-box only protein 35F-box- and WD40-repeat-containing protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000395443, ENST00000357496, 
ENST00000424300, ENST00000479449, 
ENST00000296438, ENST00000415155, 
ENST00000445170, ENST00000436231, 
ENST00000468158, 
Fusion gene scores* DoF score19 X 13 X 10=24705 X 5 X 5=125
# samples 208
** MAII scorelog2(20/2470*10)=-3.62643913669732
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/125*10)=-0.643856189774725
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: QRICH1 [Title/Abstract] AND FBXW12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointQRICH1(49114141)-FBXW12(48414797), # samples:1
QRICH1(49114142)-FBXW12(48415038), # samples:1
Anticipated loss of major functional domain due to fusion event.QRICH1-FBXW12 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across QRICH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FBXW12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8364QRICH1chr3

49114141

-FBXW12chr3

48414797

+
ChimerDB4STADTCGA-BR-8364-01AQRICH1chr3

49114142

-FBXW12chr3

48415038

+


Top

Fusion Gene ORF analysis for QRICH1-FBXW12

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000395443ENST00000296438QRICH1chr3

49114141

-FBXW12chr3

48414797

+
Frame-shiftENST00000395443ENST00000415155QRICH1chr3

49114141

-FBXW12chr3

48414797

+
Frame-shiftENST00000395443ENST00000445170QRICH1chr3

49114141

-FBXW12chr3

48414797

+
5CDS-intronENST00000395443ENST00000436231QRICH1chr3

49114141

-FBXW12chr3

48414797

+
5CDS-intronENST00000395443ENST00000468158QRICH1chr3

49114141

-FBXW12chr3

48414797

+
Frame-shiftENST00000357496ENST00000296438QRICH1chr3

49114141

-FBXW12chr3

48414797

+
Frame-shiftENST00000357496ENST00000415155QRICH1chr3

49114141

-FBXW12chr3

48414797

+
Frame-shiftENST00000357496ENST00000445170QRICH1chr3

49114141

-FBXW12chr3

48414797

+
5CDS-intronENST00000357496ENST00000436231QRICH1chr3

49114141

-FBXW12chr3

48414797

+
5CDS-intronENST00000357496ENST00000468158QRICH1chr3

49114141

-FBXW12chr3

48414797

+
Frame-shiftENST00000424300ENST00000296438QRICH1chr3

49114141

-FBXW12chr3

48414797

+
Frame-shiftENST00000424300ENST00000415155QRICH1chr3

49114141

-FBXW12chr3

48414797

+
Frame-shiftENST00000424300ENST00000445170QRICH1chr3

49114141

-FBXW12chr3

48414797

+
5CDS-intronENST00000424300ENST00000436231QRICH1chr3

49114141

-FBXW12chr3

48414797

+
5CDS-intronENST00000424300ENST00000468158QRICH1chr3

49114141

-FBXW12chr3

48414797

+
intron-3CDSENST00000479449ENST00000296438QRICH1chr3

49114141

-FBXW12chr3

48414797

+
intron-3CDSENST00000479449ENST00000415155QRICH1chr3

49114141

-FBXW12chr3

48414797

+
intron-3CDSENST00000479449ENST00000445170QRICH1chr3

49114141

-FBXW12chr3

48414797

+
intron-intronENST00000479449ENST00000436231QRICH1chr3

49114141

-FBXW12chr3

48414797

+
intron-intronENST00000479449ENST00000468158QRICH1chr3

49114141

-FBXW12chr3

48414797

+
In-frameENST00000395443ENST00000296438QRICH1chr3

49114142

-FBXW12chr3

48415038

+
In-frameENST00000395443ENST00000415155QRICH1chr3

49114142

-FBXW12chr3

48415038

+
In-frameENST00000395443ENST00000445170QRICH1chr3

49114142

-FBXW12chr3

48415038

+
5CDS-intronENST00000395443ENST00000436231QRICH1chr3

49114142

-FBXW12chr3

48415038

+
5CDS-intronENST00000395443ENST00000468158QRICH1chr3

49114142

-FBXW12chr3

48415038

+
In-frameENST00000357496ENST00000296438QRICH1chr3

49114142

-FBXW12chr3

48415038

+
In-frameENST00000357496ENST00000415155QRICH1chr3

49114142

-FBXW12chr3

48415038

+
In-frameENST00000357496ENST00000445170QRICH1chr3

49114142

-FBXW12chr3

48415038

+
5CDS-intronENST00000357496ENST00000436231QRICH1chr3

49114142

-FBXW12chr3

48415038

+
5CDS-intronENST00000357496ENST00000468158QRICH1chr3

49114142

-FBXW12chr3

48415038

+
In-frameENST00000424300ENST00000296438QRICH1chr3

49114142

-FBXW12chr3

48415038

+
In-frameENST00000424300ENST00000415155QRICH1chr3

49114142

-FBXW12chr3

48415038

+
In-frameENST00000424300ENST00000445170QRICH1chr3

49114142

-FBXW12chr3

48415038

+
5CDS-intronENST00000424300ENST00000436231QRICH1chr3

49114142

-FBXW12chr3

48415038

+
5CDS-intronENST00000424300ENST00000468158QRICH1chr3

49114142

-FBXW12chr3

48415038

+
intron-3CDSENST00000479449ENST00000296438QRICH1chr3

49114142

-FBXW12chr3

48415038

+
intron-3CDSENST00000479449ENST00000415155QRICH1chr3

49114142

-FBXW12chr3

48415038

+
intron-3CDSENST00000479449ENST00000445170QRICH1chr3

49114142

-FBXW12chr3

48415038

+
intron-intronENST00000479449ENST00000436231QRICH1chr3

49114142

-FBXW12chr3

48415038

+
intron-intronENST00000479449ENST00000468158QRICH1chr3

49114142

-FBXW12chr3

48415038

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000395443QRICH1chr349114142-ENST00000296438FBXW12chr348415038+21157826722048458
ENST00000395443QRICH1chr349114142-ENST00000415155FBXW12chr348415038+18677826721838388
ENST00000395443QRICH1chr349114142-ENST00000445170FBXW12chr348415038+20777826722048458
ENST00000357496QRICH1chr349114142-ENST00000296438FBXW12chr348415038+18745414311807458
ENST00000357496QRICH1chr349114142-ENST00000415155FBXW12chr348415038+16265414311597388
ENST00000357496QRICH1chr349114142-ENST00000445170FBXW12chr348415038+18365414311807458
ENST00000424300QRICH1chr349114142-ENST00000296438FBXW12chr348415038+20807476372013458
ENST00000424300QRICH1chr349114142-ENST00000415155FBXW12chr348415038+18327476371803388
ENST00000424300QRICH1chr349114142-ENST00000445170FBXW12chr348415038+20427476372013458

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000395443ENST00000296438QRICH1chr349114142-FBXW12chr348415038+0.0058273640.99417263
ENST00000395443ENST00000415155QRICH1chr349114142-FBXW12chr348415038+0.0106791030.9893209
ENST00000395443ENST00000445170QRICH1chr349114142-FBXW12chr348415038+0.0065783530.9934216
ENST00000357496ENST00000296438QRICH1chr349114142-FBXW12chr348415038+0.0060143390.9939857
ENST00000357496ENST00000415155QRICH1chr349114142-FBXW12chr348415038+0.0090738620.99092615
ENST00000357496ENST00000445170QRICH1chr349114142-FBXW12chr348415038+0.0068205260.99317944
ENST00000424300ENST00000296438QRICH1chr349114142-FBXW12chr348415038+0.0053598710.9946402
ENST00000424300ENST00000415155QRICH1chr349114142-FBXW12chr348415038+0.0144113280.9855886
ENST00000424300ENST00000445170QRICH1chr349114142-FBXW12chr348415038+0.0057142230.99428576

Top

Fusion Genomic Features for QRICH1-FBXW12


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
QRICH1chr349114141-FBXW12chr348414797+3.59E-091
QRICH1chr349114141-FBXW12chr348415037+2.56E-081
QRICH1chr349114141-FBXW12chr348414797+3.59E-091
QRICH1chr349114141-FBXW12chr348415037+2.56E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for QRICH1-FBXW12


check button Go to

FGviewer for the breakpoints of chr3:49114142-chr3:48415038

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneQRICH1chr3:49114142chr3:48415038ENST00000357496-3111_64103.0777.0DomainNote=CARD
HgeneQRICH1chr3:49114142chr3:48415038ENST00000395443-2101_64103.0777.0DomainNote=CARD
HgeneQRICH1chr3:49114142chr3:48415038ENST00000424300-3111_64103.0777.0DomainNote=CARD
TgeneFBXW12chr3:49114142chr3:48415038ENST00000296438211136_17442.666666666666664465.0RepeatNote=WD 2
TgeneFBXW12chr3:49114142chr3:48415038ENST00000296438211178_21742.666666666666664465.0RepeatNote=WD 3
TgeneFBXW12chr3:49114142chr3:48415038ENST00000296438211222_26342.666666666666664465.0RepeatNote=WD 4
TgeneFBXW12chr3:49114142chr3:48415038ENST00000296438211270_31542.666666666666664465.0RepeatNote=WD 5
TgeneFBXW12chr3:49114142chr3:48415038ENST00000296438211320_36742.666666666666664465.0RepeatNote=WD 6
TgeneFBXW12chr3:49114142chr3:48415038ENST00000296438211370_40742.666666666666664465.0RepeatNote=WD 7
TgeneFBXW12chr3:49114142chr3:48415038ENST00000296438211416_46142.666666666666664465.0RepeatNote=WD 8
TgeneFBXW12chr3:49114142chr3:48415038ENST0000029643821189_13242.666666666666664465.0RepeatNote=WD 1
TgeneFBXW12chr3:49114142chr3:48415038ENST00000415155210136_17442.666666666666664395.0RepeatNote=WD 2
TgeneFBXW12chr3:49114142chr3:48415038ENST00000415155210178_21742.666666666666664395.0RepeatNote=WD 3
TgeneFBXW12chr3:49114142chr3:48415038ENST00000415155210222_26342.666666666666664395.0RepeatNote=WD 4
TgeneFBXW12chr3:49114142chr3:48415038ENST00000415155210270_31542.666666666666664395.0RepeatNote=WD 5
TgeneFBXW12chr3:49114142chr3:48415038ENST00000415155210320_36742.666666666666664395.0RepeatNote=WD 6
TgeneFBXW12chr3:49114142chr3:48415038ENST00000415155210370_40742.666666666666664395.0RepeatNote=WD 7
TgeneFBXW12chr3:49114142chr3:48415038ENST00000415155210416_46142.666666666666664395.0RepeatNote=WD 8
TgeneFBXW12chr3:49114142chr3:48415038ENST0000041515521089_13242.666666666666664395.0RepeatNote=WD 1
TgeneFBXW12chr3:49114142chr3:48415038ENST00000445170110136_17423.666666666666668446.0RepeatNote=WD 2
TgeneFBXW12chr3:49114142chr3:48415038ENST00000445170110178_21723.666666666666668446.0RepeatNote=WD 3
TgeneFBXW12chr3:49114142chr3:48415038ENST00000445170110222_26323.666666666666668446.0RepeatNote=WD 4
TgeneFBXW12chr3:49114142chr3:48415038ENST00000445170110270_31523.666666666666668446.0RepeatNote=WD 5
TgeneFBXW12chr3:49114142chr3:48415038ENST00000445170110320_36723.666666666666668446.0RepeatNote=WD 6
TgeneFBXW12chr3:49114142chr3:48415038ENST00000445170110370_40723.666666666666668446.0RepeatNote=WD 7
TgeneFBXW12chr3:49114142chr3:48415038ENST00000445170110416_46123.666666666666668446.0RepeatNote=WD 8
TgeneFBXW12chr3:49114142chr3:48415038ENST0000044517011089_13223.666666666666668446.0RepeatNote=WD 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneQRICH1chr3:49114142chr3:48415038ENST00000357496-31185_462103.0777.0Compositional biasNote=Gln-rich
HgeneQRICH1chr3:49114142chr3:48415038ENST00000395443-21085_462103.0777.0Compositional biasNote=Gln-rich
HgeneQRICH1chr3:49114142chr3:48415038ENST00000424300-31185_462103.0777.0Compositional biasNote=Gln-rich
TgeneFBXW12chr3:49114142chr3:48415038ENST000002964382111_4542.666666666666664465.0DomainF-box
TgeneFBXW12chr3:49114142chr3:48415038ENST000004151552101_4542.666666666666664395.0DomainF-box
TgeneFBXW12chr3:49114142chr3:48415038ENST000004451701101_4523.666666666666668446.0DomainF-box


Top

Fusion Gene Sequence for QRICH1-FBXW12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000395443_ENST00000296438_TCGA-BR-8364-01A_QRICH1_chr3_49114142_-_FBXW12_chr3_48415038_length(transcript)=2115nt_BP=782nt
AAAGGAGGCTCTGGCGGGCGACGGAAGGTGGGTCCAAAGAGCTAGCTTGGAGCCCTAGCCTTCCGAGACTCCACTACTAGGCCAAGCCAC
GGCCCTAGCTCCGCCCCACATGGAGAGGCGTCCATGGGCGGAGCGAGCCGCTCCATACCCTAGGATCCACTATCCGCTCTAGCGGCCAGA
AGCGCGGCCACCTTCCCCTGCTGAAGCGTTCACTTTAATTTTGGCCGGTAGGCAGTCCCAGATCTCGCGGGATCCGACGCCCCGATTATC
GCGAGAGGAGCAATCGGCTCCTATTGGCTGTGAGGGTTGAATGTAAGATGGCGCCCAGGGAGCTGTGAGGAGAAAACCCTGTCGGTCTTG
GAGCGACGACGGCAGAACCAGGGTCCCTGGCGGTGCGGCGGGGCCGGCGGGTGCAGCGGAGGCGGCGGCGGCGGCGGCAGTGACGTCGCC
GGGAACCCTAAGGACTCTGCAATATGAATAATTCCCTAGAGAACACCATCTCCTTTGAAGAGTACATCCGAGTAAAGGCACGGTCTGTCC
CGCAACACAGGATGAAGGAATTTCTGGACTCACTGGCCTCTAAGGGGCCAGAAGCCCTTCAGGAGTTCCAGCAGACAGCCACCACTACCA
TGGTGTACCAACAGGGTGGGAACTGCATATACACAGACAGCACTGAAGTGGCTGGGTCTTTGCTTGAACTTGCCTGTCCAGTCACCACCA
GTGTTCAGCCACAAACCCAGCAAGAACAGCAGATCCAGGTTCAGCAGCCGCAGCAGGTTCAGGTCACTATCTCTGCAGAGATGGGACTGC
AGCAACTTCACCAATCAACACCTGGGCACACACACATGGAAGCAATTTTTCCTGCATCAAAGAAGGAAGGAGCTTCGGTTGGCATTGGCA
CAGCCGCATAACTTTATCTACAAAGTAACTAAGAACATCGCATTTGAGACGGAGTTGGCTTATCTCTCAGGAAATAGACTTACAGTGGAT
GAACAGGAGAAATCAATCATTTGTAGTGTATCTCCAAAGCAAGAGCTTTGTGCCTGGGATGTGCAAGAGGGTACCATGATCTGGTCAAGC
CCAGTCCAGGAGTTCCATTTCTCAAATCTGGTAACCCTCCCTCAGATGCATCTCGCCATCACTATGGATCGGAAAAAAACTATCAAAGTG
TGGAACTGTCAGGACAGGGACGCTCTGGCTGTTCTCCCCATGCCACAGCCCTGTTATTGCATGGAAGCCTATCTTACAAAGGATGGCCCA
TTCCTGATGGTTGGCGATGCTGCAGGTGACATCTACACATTTACACTGCCTGGGTTAAGAGATGTTTCTAAAGTTACTGCATTTCAATAT
GGTATTGTACTTCTACACTGCTCTCCTGACAAGAAATGGGTATTTGCATGTGGGACATACAGTCGTACCTTGCCACAGGTATTCCTCACA
GAGTCCTTACTGAGACCATCAGAAGGCAGTGTTCCTCTGTCTACCTTTCTCCCACATAAATTATGTGCCAGCGCCTGCTGGACCCCAAAG
GTGAAAAACAGGATAACACTGATGTCCCAAAGTAGCACTGGAAAAAAGACAGAATTTATCACCTTTGATCTAACAACCAAGAAGACTGGA
GGCCAAACAGTCATCCAAGCATATGAGATCGCAAGTTTCCAGGTGGCAGCTCATCTGAAGTGCCCTATCTGGATGGGAGCCAGTGATGGA
TATATGATTGTCTTTACCAGTGGACCATACTTGTTACTCTTCAGCATCACTGGCTTCCTGCTGCAACGATTTGAGGACCATCAGGCAGCC
ATCAACAACTTCTGGGTGGATCCTTGCTATGTGCTCACCACATCCGAGAACTCTGTGCACGTGTACATGTGGGAAGAAGGAGGCCGCCAT
CCATACCTCAGGAGCTGCTGTCACCTGGAAAACACGTGGCATGATCACACAACAGACAGCTGCATCTCCAGTGTGATGTGTGATAATGCA
AGCATAGTACTTAGGGTGAGGAAAGTAAGTGACTCCAGCATTCTGGTGATGTATTCTTTGAATACGTAATATGGAAACTAACAAAATTGA

>In-frame_ENST00000395443_ENST00000296438_TCGA-BR-8364-01A_QRICH1_chr3_49114142_-_FBXW12_chr3_48415038_length(amino acids)=458AA_start in transcript=672_stop in transcript=2048
MKWLGLCLNLPVQSPPVFSHKPSKNSRSRFSSRSRFRSLSLQRWDCSNFTNQHLGTHTWKQFFLHQRRKELRLALAQPHNFIYKVTKNIA
FETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPM
PQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLS
TFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLF
SITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISSVMCDNASIVLRVRKVSDSSI

--------------------------------------------------------------
>In-frame_ENST00000395443_ENST00000415155_TCGA-BR-8364-01A_QRICH1_chr3_49114142_-_FBXW12_chr3_48415038_length(transcript)=1867nt_BP=782nt
AAAGGAGGCTCTGGCGGGCGACGGAAGGTGGGTCCAAAGAGCTAGCTTGGAGCCCTAGCCTTCCGAGACTCCACTACTAGGCCAAGCCAC
GGCCCTAGCTCCGCCCCACATGGAGAGGCGTCCATGGGCGGAGCGAGCCGCTCCATACCCTAGGATCCACTATCCGCTCTAGCGGCCAGA
AGCGCGGCCACCTTCCCCTGCTGAAGCGTTCACTTTAATTTTGGCCGGTAGGCAGTCCCAGATCTCGCGGGATCCGACGCCCCGATTATC
GCGAGAGGAGCAATCGGCTCCTATTGGCTGTGAGGGTTGAATGTAAGATGGCGCCCAGGGAGCTGTGAGGAGAAAACCCTGTCGGTCTTG
GAGCGACGACGGCAGAACCAGGGTCCCTGGCGGTGCGGCGGGGCCGGCGGGTGCAGCGGAGGCGGCGGCGGCGGCGGCAGTGACGTCGCC
GGGAACCCTAAGGACTCTGCAATATGAATAATTCCCTAGAGAACACCATCTCCTTTGAAGAGTACATCCGAGTAAAGGCACGGTCTGTCC
CGCAACACAGGATGAAGGAATTTCTGGACTCACTGGCCTCTAAGGGGCCAGAAGCCCTTCAGGAGTTCCAGCAGACAGCCACCACTACCA
TGGTGTACCAACAGGGTGGGAACTGCATATACACAGACAGCACTGAAGTGGCTGGGTCTTTGCTTGAACTTGCCTGTCCAGTCACCACCA
GTGTTCAGCCACAAACCCAGCAAGAACAGCAGATCCAGGTTCAGCAGCCGCAGCAGGTTCAGGTCACTATCTCTGCAGAGATGGGACTGC
AGCAACTTCACCAATCAACACCTGGGCACACACACATGGAAGCAATTTTTCCTGCATCAAAGAAGGAAGGAGCTTCGGTTGGCATTGGCA
CAGCCGCATAACTTTATCTACAAAGTAACTAAGAACATCGCATTTGAGACGGAGTTGGCTTATCTCTCAGGAAATAGACTTACAGTGGAT
GAACAGGAGAAATCAATCATTTGTAGTGTATCTCCAAAGCAAGAGCTTTGTGCCTGGGATGTGCAAGAGGTTGGCGATGCTGCAGGTGAC
ATCTACACATTTACACTGCCTGGGTTAAGAGATGTTTCTAAAGTTACTGCATTTCAATATGGTATTGTACTTCTACACTGCTCTCCTGAC
AAGAAATGGGTATTTGCATGTGGGACATACAGTCGTACCTTGCCACAGGTATTCCTCACAGAGTCCTTACTGAGACCATCAGAAGGCAGT
GTTCCTCTGTCTACCTTTCTCCCACATAAATTATGTGCCAGCGCCTGCTGGACCCCAAAGGTGAAAAACAGGATAACACTGATGTCCCAA
AGTAGCACTGGAAAAAAGACAGAATTTATCACCTTTGATCTAACAACCAAGAAGACTGGAGGCCAAACAGTCATCCAAGCATATGAGATC
GCAAGTTTCCAGGTGGCAGCTCATCTGAAGTGCCCTATCTGGATGGGAGCCAGTGATGGATATATGATTGTCTTTACCAGTGGACCATAC
TTGTTACTCTTCAGCATCACTGGCTTCCTGCTGCAACGATTTGAGGACCATCAGGCAGCCATCAACAACTTCTGGGTGGATCCTTGCTAT
GTGCTCACCACATCCGAGAACTCTGTGCACGTGTACATGTGGGAAGAAGGAGGCCGCCATCCATACCTCAGGAGCTGCTGTCACCTGGAA
AACACGTGGCATGATCACACAACAGACAGCTGCATCTCCAGTGTGATGTGTGATAATGCAAGCATAGTACTTAGGGTGAGGAAAGTAAGT

>In-frame_ENST00000395443_ENST00000415155_TCGA-BR-8364-01A_QRICH1_chr3_49114142_-_FBXW12_chr3_48415038_length(amino acids)=388AA_start in transcript=672_stop in transcript=1838
MKWLGLCLNLPVQSPPVFSHKPSKNSRSRFSSRSRFRSLSLQRWDCSNFTNQHLGTHTWKQFFLHQRRKELRLALAQPHNFIYKVTKNIA
FETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTL
PQVFLTESLLRPSEGSVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIW
MGASDGYMIVFTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISS

--------------------------------------------------------------
>In-frame_ENST00000395443_ENST00000445170_TCGA-BR-8364-01A_QRICH1_chr3_49114142_-_FBXW12_chr3_48415038_length(transcript)=2077nt_BP=782nt
AAAGGAGGCTCTGGCGGGCGACGGAAGGTGGGTCCAAAGAGCTAGCTTGGAGCCCTAGCCTTCCGAGACTCCACTACTAGGCCAAGCCAC
GGCCCTAGCTCCGCCCCACATGGAGAGGCGTCCATGGGCGGAGCGAGCCGCTCCATACCCTAGGATCCACTATCCGCTCTAGCGGCCAGA
AGCGCGGCCACCTTCCCCTGCTGAAGCGTTCACTTTAATTTTGGCCGGTAGGCAGTCCCAGATCTCGCGGGATCCGACGCCCCGATTATC
GCGAGAGGAGCAATCGGCTCCTATTGGCTGTGAGGGTTGAATGTAAGATGGCGCCCAGGGAGCTGTGAGGAGAAAACCCTGTCGGTCTTG
GAGCGACGACGGCAGAACCAGGGTCCCTGGCGGTGCGGCGGGGCCGGCGGGTGCAGCGGAGGCGGCGGCGGCGGCGGCAGTGACGTCGCC
GGGAACCCTAAGGACTCTGCAATATGAATAATTCCCTAGAGAACACCATCTCCTTTGAAGAGTACATCCGAGTAAAGGCACGGTCTGTCC
CGCAACACAGGATGAAGGAATTTCTGGACTCACTGGCCTCTAAGGGGCCAGAAGCCCTTCAGGAGTTCCAGCAGACAGCCACCACTACCA
TGGTGTACCAACAGGGTGGGAACTGCATATACACAGACAGCACTGAAGTGGCTGGGTCTTTGCTTGAACTTGCCTGTCCAGTCACCACCA
GTGTTCAGCCACAAACCCAGCAAGAACAGCAGATCCAGGTTCAGCAGCCGCAGCAGGTTCAGGTCACTATCTCTGCAGAGATGGGACTGC
AGCAACTTCACCAATCAACACCTGGGCACACACACATGGAAGCAATTTTTCCTGCATCAAAGAAGGAAGGAGCTTCGGTTGGCATTGGCA
CAGCCGCATAACTTTATCTACAAAGTAACTAAGAACATCGCATTTGAGACGGAGTTGGCTTATCTCTCAGGAAATAGACTTACAGTGGAT
GAACAGGAGAAATCAATCATTTGTAGTGTATCTCCAAAGCAAGAGCTTTGTGCCTGGGATGTGCAAGAGGGTACCATGATCTGGTCAAGC
CCAGTCCAGGAGTTCCATTTCTCAAATCTGGTAACCCTCCCTCAGATGCATCTCGCCATCACTATGGATCGGAAAAAAACTATCAAAGTG
TGGAACTGTCAGGACAGGGACGCTCTGGCTGTTCTCCCCATGCCACAGCCCTGTTATTGCATGGAAGCCTATCTTACAAAGGATGGCCCA
TTCCTGATGGTTGGCGATGCTGCAGGTGACATCTACACATTTACACTGCCTGGGTTAAGAGATGTTTCTAAAGTTACTGCATTTCAATAT
GGTATTGTACTTCTACACTGCTCTCCTGACAAGAAATGGGTATTTGCATGTGGGACATACAGTCGTACCTTGCCACAGGTATTCCTCACA
GAGTCCTTACTGAGACCATCAGAAGGCAGTGTTCCTCTGTCTACCTTTCTCCCACATAAATTATGTGCCAGCGCCTGCTGGACCCCAAAG
GTGAAAAACAGGATAACACTGATGTCCCAAAGTAGCACTGGAAAAAAGACAGAATTTATCACCTTTGATCTAACAACCAAGAAGACTGGA
GGCCAAACAGTCATCCAAGCATATGAGATCGCAAGTTTCCAGGTGGCAGCTCATCTGAAGTGCCCTATCTGGATGGGAGCCAGTGATGGA
TATATGATTGTCTTTACCAGTGGACCATACTTGTTACTCTTCAGCATCACTGGCTTCCTGCTGCAACGATTTGAGGACCATCAGGCAGCC
ATCAACAACTTCTGGGTGGATCCTTGCTATGTGCTCACCACATCCGAGAACTCTGTGCACGTGTACATGTGGGAAGAAGGAGGCCGCCAT
CCATACCTCAGGAGCTGCTGTCACCTGGAAAACACGTGGCATGATCACACAACAGACAGCTGCATCTCCAGTGTGATGTGTGATAATGCA
AGCATAGTACTTAGGGTGAGGAAAGTAAGTGACTCCAGCATTCTGGTGATGTATTCTTTGAATACGTAATATGGAAACTAACAAAATTGA

>In-frame_ENST00000395443_ENST00000445170_TCGA-BR-8364-01A_QRICH1_chr3_49114142_-_FBXW12_chr3_48415038_length(amino acids)=458AA_start in transcript=672_stop in transcript=2048
MKWLGLCLNLPVQSPPVFSHKPSKNSRSRFSSRSRFRSLSLQRWDCSNFTNQHLGTHTWKQFFLHQRRKELRLALAQPHNFIYKVTKNIA
FETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPM
PQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLS
TFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLF
SITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISSVMCDNASIVLRVRKVSDSSI

--------------------------------------------------------------
>In-frame_ENST00000357496_ENST00000296438_TCGA-BR-8364-01A_QRICH1_chr3_49114142_-_FBXW12_chr3_48415038_length(transcript)=1874nt_BP=541nt
GAGGGTTGAATGTAAGATGGCGCCCAGGGAGCTGTGAGGAGAAAACCCTGTCGGTCTTGGAGCGACGACGGCAGAACCAGGGTCCCTGGC
GGTGCGGCGGGGCCGGCGGGTGCAGCGGAGGCGGCGGCGGCGGCGGCAGTGACGTCGCCGGAATATTAGAAGTCTTAAGAACTCAGGACA
AGCAGCAGAAATACATGCAACATGGTGACTGGAACCCTAAGGACTCTGCAATATGAATAATTCCCTAGAGAACACCATCTCCTTTGAAGA
GTACATCCGAGTAAAGGCACGGTCTGTCCCGCAACACAGGATGAAGGAATTTCTGGACTCACTGGCCTCTAAGGGGCCAGAAGCCCTTCA
GGAGTTCCAGCAGACAGCCACCACTACCATGGTGTACCAACAGGGTGGGAACTGCATATACACAGACAGCACTGAAGTGGCTGGGTCTTT
GCTTGAACTTGCCTGTCCAGTCACCACCAGTGTTCAGCCACAAACCCAGCAAGAACAGCAGATCCAGGTTCAGCAGCCGCAGCAGGTTCA
GGTCACTATCTCTGCAGAGATGGGACTGCAGCAACTTCACCAATCAACACCTGGGCACACACACATGGAAGCAATTTTTCCTGCATCAAA
GAAGGAAGGAGCTTCGGTTGGCATTGGCACAGCCGCATAACTTTATCTACAAAGTAACTAAGAACATCGCATTTGAGACGGAGTTGGCTT
ATCTCTCAGGAAATAGACTTACAGTGGATGAACAGGAGAAATCAATCATTTGTAGTGTATCTCCAAAGCAAGAGCTTTGTGCCTGGGATG
TGCAAGAGGGTACCATGATCTGGTCAAGCCCAGTCCAGGAGTTCCATTTCTCAAATCTGGTAACCCTCCCTCAGATGCATCTCGCCATCA
CTATGGATCGGAAAAAAACTATCAAAGTGTGGAACTGTCAGGACAGGGACGCTCTGGCTGTTCTCCCCATGCCACAGCCCTGTTATTGCA
TGGAAGCCTATCTTACAAAGGATGGCCCATTCCTGATGGTTGGCGATGCTGCAGGTGACATCTACACATTTACACTGCCTGGGTTAAGAG
ATGTTTCTAAAGTTACTGCATTTCAATATGGTATTGTACTTCTACACTGCTCTCCTGACAAGAAATGGGTATTTGCATGTGGGACATACA
GTCGTACCTTGCCACAGGTATTCCTCACAGAGTCCTTACTGAGACCATCAGAAGGCAGTGTTCCTCTGTCTACCTTTCTCCCACATAAAT
TATGTGCCAGCGCCTGCTGGACCCCAAAGGTGAAAAACAGGATAACACTGATGTCCCAAAGTAGCACTGGAAAAAAGACAGAATTTATCA
CCTTTGATCTAACAACCAAGAAGACTGGAGGCCAAACAGTCATCCAAGCATATGAGATCGCAAGTTTCCAGGTGGCAGCTCATCTGAAGT
GCCCTATCTGGATGGGAGCCAGTGATGGATATATGATTGTCTTTACCAGTGGACCATACTTGTTACTCTTCAGCATCACTGGCTTCCTGC
TGCAACGATTTGAGGACCATCAGGCAGCCATCAACAACTTCTGGGTGGATCCTTGCTATGTGCTCACCACATCCGAGAACTCTGTGCACG
TGTACATGTGGGAAGAAGGAGGCCGCCATCCATACCTCAGGAGCTGCTGTCACCTGGAAAACACGTGGCATGATCACACAACAGACAGCT
GCATCTCCAGTGTGATGTGTGATAATGCAAGCATAGTACTTAGGGTGAGGAAAGTAAGTGACTCCAGCATTCTGGTGATGTATTCTTTGA

>In-frame_ENST00000357496_ENST00000296438_TCGA-BR-8364-01A_QRICH1_chr3_49114142_-_FBXW12_chr3_48415038_length(amino acids)=458AA_start in transcript=431_stop in transcript=1807
MKWLGLCLNLPVQSPPVFSHKPSKNSRSRFSSRSRFRSLSLQRWDCSNFTNQHLGTHTWKQFFLHQRRKELRLALAQPHNFIYKVTKNIA
FETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPM
PQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLS
TFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLF
SITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISSVMCDNASIVLRVRKVSDSSI

--------------------------------------------------------------
>In-frame_ENST00000357496_ENST00000415155_TCGA-BR-8364-01A_QRICH1_chr3_49114142_-_FBXW12_chr3_48415038_length(transcript)=1626nt_BP=541nt
GAGGGTTGAATGTAAGATGGCGCCCAGGGAGCTGTGAGGAGAAAACCCTGTCGGTCTTGGAGCGACGACGGCAGAACCAGGGTCCCTGGC
GGTGCGGCGGGGCCGGCGGGTGCAGCGGAGGCGGCGGCGGCGGCGGCAGTGACGTCGCCGGAATATTAGAAGTCTTAAGAACTCAGGACA
AGCAGCAGAAATACATGCAACATGGTGACTGGAACCCTAAGGACTCTGCAATATGAATAATTCCCTAGAGAACACCATCTCCTTTGAAGA
GTACATCCGAGTAAAGGCACGGTCTGTCCCGCAACACAGGATGAAGGAATTTCTGGACTCACTGGCCTCTAAGGGGCCAGAAGCCCTTCA
GGAGTTCCAGCAGACAGCCACCACTACCATGGTGTACCAACAGGGTGGGAACTGCATATACACAGACAGCACTGAAGTGGCTGGGTCTTT
GCTTGAACTTGCCTGTCCAGTCACCACCAGTGTTCAGCCACAAACCCAGCAAGAACAGCAGATCCAGGTTCAGCAGCCGCAGCAGGTTCA
GGTCACTATCTCTGCAGAGATGGGACTGCAGCAACTTCACCAATCAACACCTGGGCACACACACATGGAAGCAATTTTTCCTGCATCAAA
GAAGGAAGGAGCTTCGGTTGGCATTGGCACAGCCGCATAACTTTATCTACAAAGTAACTAAGAACATCGCATTTGAGACGGAGTTGGCTT
ATCTCTCAGGAAATAGACTTACAGTGGATGAACAGGAGAAATCAATCATTTGTAGTGTATCTCCAAAGCAAGAGCTTTGTGCCTGGGATG
TGCAAGAGGTTGGCGATGCTGCAGGTGACATCTACACATTTACACTGCCTGGGTTAAGAGATGTTTCTAAAGTTACTGCATTTCAATATG
GTATTGTACTTCTACACTGCTCTCCTGACAAGAAATGGGTATTTGCATGTGGGACATACAGTCGTACCTTGCCACAGGTATTCCTCACAG
AGTCCTTACTGAGACCATCAGAAGGCAGTGTTCCTCTGTCTACCTTTCTCCCACATAAATTATGTGCCAGCGCCTGCTGGACCCCAAAGG
TGAAAAACAGGATAACACTGATGTCCCAAAGTAGCACTGGAAAAAAGACAGAATTTATCACCTTTGATCTAACAACCAAGAAGACTGGAG
GCCAAACAGTCATCCAAGCATATGAGATCGCAAGTTTCCAGGTGGCAGCTCATCTGAAGTGCCCTATCTGGATGGGAGCCAGTGATGGAT
ATATGATTGTCTTTACCAGTGGACCATACTTGTTACTCTTCAGCATCACTGGCTTCCTGCTGCAACGATTTGAGGACCATCAGGCAGCCA
TCAACAACTTCTGGGTGGATCCTTGCTATGTGCTCACCACATCCGAGAACTCTGTGCACGTGTACATGTGGGAAGAAGGAGGCCGCCATC
CATACCTCAGGAGCTGCTGTCACCTGGAAAACACGTGGCATGATCACACAACAGACAGCTGCATCTCCAGTGTGATGTGTGATAATGCAA
GCATAGTACTTAGGGTGAGGAAAGTAAGTGACTCCAGCATTCTGGTGATGTATTCTTTGAATACGTAATATGGAAACTAACAAAATTGAC

>In-frame_ENST00000357496_ENST00000415155_TCGA-BR-8364-01A_QRICH1_chr3_49114142_-_FBXW12_chr3_48415038_length(amino acids)=388AA_start in transcript=431_stop in transcript=1597
MKWLGLCLNLPVQSPPVFSHKPSKNSRSRFSSRSRFRSLSLQRWDCSNFTNQHLGTHTWKQFFLHQRRKELRLALAQPHNFIYKVTKNIA
FETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTL
PQVFLTESLLRPSEGSVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIW
MGASDGYMIVFTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISS

--------------------------------------------------------------
>In-frame_ENST00000357496_ENST00000445170_TCGA-BR-8364-01A_QRICH1_chr3_49114142_-_FBXW12_chr3_48415038_length(transcript)=1836nt_BP=541nt
GAGGGTTGAATGTAAGATGGCGCCCAGGGAGCTGTGAGGAGAAAACCCTGTCGGTCTTGGAGCGACGACGGCAGAACCAGGGTCCCTGGC
GGTGCGGCGGGGCCGGCGGGTGCAGCGGAGGCGGCGGCGGCGGCGGCAGTGACGTCGCCGGAATATTAGAAGTCTTAAGAACTCAGGACA
AGCAGCAGAAATACATGCAACATGGTGACTGGAACCCTAAGGACTCTGCAATATGAATAATTCCCTAGAGAACACCATCTCCTTTGAAGA
GTACATCCGAGTAAAGGCACGGTCTGTCCCGCAACACAGGATGAAGGAATTTCTGGACTCACTGGCCTCTAAGGGGCCAGAAGCCCTTCA
GGAGTTCCAGCAGACAGCCACCACTACCATGGTGTACCAACAGGGTGGGAACTGCATATACACAGACAGCACTGAAGTGGCTGGGTCTTT
GCTTGAACTTGCCTGTCCAGTCACCACCAGTGTTCAGCCACAAACCCAGCAAGAACAGCAGATCCAGGTTCAGCAGCCGCAGCAGGTTCA
GGTCACTATCTCTGCAGAGATGGGACTGCAGCAACTTCACCAATCAACACCTGGGCACACACACATGGAAGCAATTTTTCCTGCATCAAA
GAAGGAAGGAGCTTCGGTTGGCATTGGCACAGCCGCATAACTTTATCTACAAAGTAACTAAGAACATCGCATTTGAGACGGAGTTGGCTT
ATCTCTCAGGAAATAGACTTACAGTGGATGAACAGGAGAAATCAATCATTTGTAGTGTATCTCCAAAGCAAGAGCTTTGTGCCTGGGATG
TGCAAGAGGGTACCATGATCTGGTCAAGCCCAGTCCAGGAGTTCCATTTCTCAAATCTGGTAACCCTCCCTCAGATGCATCTCGCCATCA
CTATGGATCGGAAAAAAACTATCAAAGTGTGGAACTGTCAGGACAGGGACGCTCTGGCTGTTCTCCCCATGCCACAGCCCTGTTATTGCA
TGGAAGCCTATCTTACAAAGGATGGCCCATTCCTGATGGTTGGCGATGCTGCAGGTGACATCTACACATTTACACTGCCTGGGTTAAGAG
ATGTTTCTAAAGTTACTGCATTTCAATATGGTATTGTACTTCTACACTGCTCTCCTGACAAGAAATGGGTATTTGCATGTGGGACATACA
GTCGTACCTTGCCACAGGTATTCCTCACAGAGTCCTTACTGAGACCATCAGAAGGCAGTGTTCCTCTGTCTACCTTTCTCCCACATAAAT
TATGTGCCAGCGCCTGCTGGACCCCAAAGGTGAAAAACAGGATAACACTGATGTCCCAAAGTAGCACTGGAAAAAAGACAGAATTTATCA
CCTTTGATCTAACAACCAAGAAGACTGGAGGCCAAACAGTCATCCAAGCATATGAGATCGCAAGTTTCCAGGTGGCAGCTCATCTGAAGT
GCCCTATCTGGATGGGAGCCAGTGATGGATATATGATTGTCTTTACCAGTGGACCATACTTGTTACTCTTCAGCATCACTGGCTTCCTGC
TGCAACGATTTGAGGACCATCAGGCAGCCATCAACAACTTCTGGGTGGATCCTTGCTATGTGCTCACCACATCCGAGAACTCTGTGCACG
TGTACATGTGGGAAGAAGGAGGCCGCCATCCATACCTCAGGAGCTGCTGTCACCTGGAAAACACGTGGCATGATCACACAACAGACAGCT
GCATCTCCAGTGTGATGTGTGATAATGCAAGCATAGTACTTAGGGTGAGGAAAGTAAGTGACTCCAGCATTCTGGTGATGTATTCTTTGA

>In-frame_ENST00000357496_ENST00000445170_TCGA-BR-8364-01A_QRICH1_chr3_49114142_-_FBXW12_chr3_48415038_length(amino acids)=458AA_start in transcript=431_stop in transcript=1807
MKWLGLCLNLPVQSPPVFSHKPSKNSRSRFSSRSRFRSLSLQRWDCSNFTNQHLGTHTWKQFFLHQRRKELRLALAQPHNFIYKVTKNIA
FETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPM
PQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLS
TFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLF
SITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISSVMCDNASIVLRVRKVSDSSI

--------------------------------------------------------------
>In-frame_ENST00000424300_ENST00000296438_TCGA-BR-8364-01A_QRICH1_chr3_49114142_-_FBXW12_chr3_48415038_length(transcript)=2080nt_BP=747nt
CGCGTTCCCGGCCCGGATATCTCTGCTCTAGGAGCTGTGGCCCGTGGGCAACCGCGGCTTTCTGGAGCGCGCGCCCGTGACGACCCCCAG
TTTTGGGGCGCGCGCTCTGATATCGGGTGGCGGTGCTGCCTCGAGAGCGCGCAGGAGGCTTCTGCTGAGCAGAGGGCCGGCCGCGGCTCG
TTGCGCTGGGAAGGTTGAGGATTGGGTCCTTTCTGGTCTGGTGACGTTCCCGGGCATCCGTGGCCTCGGCCTGGAGAGAAACCAACCAGC
TTTGCTGTCTGGCTTGCGGTTCCGCTCCTCTGTGAGGGGGGCGAGATTGCCCGTTCTCCTCGAAGAATGCCGTTACTTGAGGCCCAAAAT
ATTAGAAGTCTTAAGAACTCAGGACAAGCAGCAGAAATACATGCAACATGGTGACTGGAACCCTAAGGACTCTGCAATATGAATAATTCC
CTAGAGAACACCATCTCCTTTGAAGAGTACATCCGAGTAAAGGCACGGTCTGTCCCGCAACACAGGATGAAGGAATTTCTGGACTCACTG
GCCTCTAAGGGGCCAGAAGCCCTTCAGGAGTTCCAGCAGACAGCCACCACTACCATGGTGTACCAACAGGGTGGGAACTGCATATACACA
GACAGCACTGAAGTGGCTGGGTCTTTGCTTGAACTTGCCTGTCCAGTCACCACCAGTGTTCAGCCACAAACCCAGCAAGAACAGCAGATC
CAGGTTCAGCAGCCGCAGCAGGTTCAGGTCACTATCTCTGCAGAGATGGGACTGCAGCAACTTCACCAATCAACACCTGGGCACACACAC
ATGGAAGCAATTTTTCCTGCATCAAAGAAGGAAGGAGCTTCGGTTGGCATTGGCACAGCCGCATAACTTTATCTACAAAGTAACTAAGAA
CATCGCATTTGAGACGGAGTTGGCTTATCTCTCAGGAAATAGACTTACAGTGGATGAACAGGAGAAATCAATCATTTGTAGTGTATCTCC
AAAGCAAGAGCTTTGTGCCTGGGATGTGCAAGAGGGTACCATGATCTGGTCAAGCCCAGTCCAGGAGTTCCATTTCTCAAATCTGGTAAC
CCTCCCTCAGATGCATCTCGCCATCACTATGGATCGGAAAAAAACTATCAAAGTGTGGAACTGTCAGGACAGGGACGCTCTGGCTGTTCT
CCCCATGCCACAGCCCTGTTATTGCATGGAAGCCTATCTTACAAAGGATGGCCCATTCCTGATGGTTGGCGATGCTGCAGGTGACATCTA
CACATTTACACTGCCTGGGTTAAGAGATGTTTCTAAAGTTACTGCATTTCAATATGGTATTGTACTTCTACACTGCTCTCCTGACAAGAA
ATGGGTATTTGCATGTGGGACATACAGTCGTACCTTGCCACAGGTATTCCTCACAGAGTCCTTACTGAGACCATCAGAAGGCAGTGTTCC
TCTGTCTACCTTTCTCCCACATAAATTATGTGCCAGCGCCTGCTGGACCCCAAAGGTGAAAAACAGGATAACACTGATGTCCCAAAGTAG
CACTGGAAAAAAGACAGAATTTATCACCTTTGATCTAACAACCAAGAAGACTGGAGGCCAAACAGTCATCCAAGCATATGAGATCGCAAG
TTTCCAGGTGGCAGCTCATCTGAAGTGCCCTATCTGGATGGGAGCCAGTGATGGATATATGATTGTCTTTACCAGTGGACCATACTTGTT
ACTCTTCAGCATCACTGGCTTCCTGCTGCAACGATTTGAGGACCATCAGGCAGCCATCAACAACTTCTGGGTGGATCCTTGCTATGTGCT
CACCACATCCGAGAACTCTGTGCACGTGTACATGTGGGAAGAAGGAGGCCGCCATCCATACCTCAGGAGCTGCTGTCACCTGGAAAACAC
GTGGCATGATCACACAACAGACAGCTGCATCTCCAGTGTGATGTGTGATAATGCAAGCATAGTACTTAGGGTGAGGAAAGTAAGTGACTC
CAGCATTCTGGTGATGTATTCTTTGAATACGTAATATGGAAACTAACAAAATTGACCTTGCATCATCTTCTGCAATGTAGTAAAGAAATT

>In-frame_ENST00000424300_ENST00000296438_TCGA-BR-8364-01A_QRICH1_chr3_49114142_-_FBXW12_chr3_48415038_length(amino acids)=458AA_start in transcript=637_stop in transcript=2013
MKWLGLCLNLPVQSPPVFSHKPSKNSRSRFSSRSRFRSLSLQRWDCSNFTNQHLGTHTWKQFFLHQRRKELRLALAQPHNFIYKVTKNIA
FETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPM
PQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLS
TFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLF
SITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISSVMCDNASIVLRVRKVSDSSI

--------------------------------------------------------------
>In-frame_ENST00000424300_ENST00000415155_TCGA-BR-8364-01A_QRICH1_chr3_49114142_-_FBXW12_chr3_48415038_length(transcript)=1832nt_BP=747nt
CGCGTTCCCGGCCCGGATATCTCTGCTCTAGGAGCTGTGGCCCGTGGGCAACCGCGGCTTTCTGGAGCGCGCGCCCGTGACGACCCCCAG
TTTTGGGGCGCGCGCTCTGATATCGGGTGGCGGTGCTGCCTCGAGAGCGCGCAGGAGGCTTCTGCTGAGCAGAGGGCCGGCCGCGGCTCG
TTGCGCTGGGAAGGTTGAGGATTGGGTCCTTTCTGGTCTGGTGACGTTCCCGGGCATCCGTGGCCTCGGCCTGGAGAGAAACCAACCAGC
TTTGCTGTCTGGCTTGCGGTTCCGCTCCTCTGTGAGGGGGGCGAGATTGCCCGTTCTCCTCGAAGAATGCCGTTACTTGAGGCCCAAAAT
ATTAGAAGTCTTAAGAACTCAGGACAAGCAGCAGAAATACATGCAACATGGTGACTGGAACCCTAAGGACTCTGCAATATGAATAATTCC
CTAGAGAACACCATCTCCTTTGAAGAGTACATCCGAGTAAAGGCACGGTCTGTCCCGCAACACAGGATGAAGGAATTTCTGGACTCACTG
GCCTCTAAGGGGCCAGAAGCCCTTCAGGAGTTCCAGCAGACAGCCACCACTACCATGGTGTACCAACAGGGTGGGAACTGCATATACACA
GACAGCACTGAAGTGGCTGGGTCTTTGCTTGAACTTGCCTGTCCAGTCACCACCAGTGTTCAGCCACAAACCCAGCAAGAACAGCAGATC
CAGGTTCAGCAGCCGCAGCAGGTTCAGGTCACTATCTCTGCAGAGATGGGACTGCAGCAACTTCACCAATCAACACCTGGGCACACACAC
ATGGAAGCAATTTTTCCTGCATCAAAGAAGGAAGGAGCTTCGGTTGGCATTGGCACAGCCGCATAACTTTATCTACAAAGTAACTAAGAA
CATCGCATTTGAGACGGAGTTGGCTTATCTCTCAGGAAATAGACTTACAGTGGATGAACAGGAGAAATCAATCATTTGTAGTGTATCTCC
AAAGCAAGAGCTTTGTGCCTGGGATGTGCAAGAGGTTGGCGATGCTGCAGGTGACATCTACACATTTACACTGCCTGGGTTAAGAGATGT
TTCTAAAGTTACTGCATTTCAATATGGTATTGTACTTCTACACTGCTCTCCTGACAAGAAATGGGTATTTGCATGTGGGACATACAGTCG
TACCTTGCCACAGGTATTCCTCACAGAGTCCTTACTGAGACCATCAGAAGGCAGTGTTCCTCTGTCTACCTTTCTCCCACATAAATTATG
TGCCAGCGCCTGCTGGACCCCAAAGGTGAAAAACAGGATAACACTGATGTCCCAAAGTAGCACTGGAAAAAAGACAGAATTTATCACCTT
TGATCTAACAACCAAGAAGACTGGAGGCCAAACAGTCATCCAAGCATATGAGATCGCAAGTTTCCAGGTGGCAGCTCATCTGAAGTGCCC
TATCTGGATGGGAGCCAGTGATGGATATATGATTGTCTTTACCAGTGGACCATACTTGTTACTCTTCAGCATCACTGGCTTCCTGCTGCA
ACGATTTGAGGACCATCAGGCAGCCATCAACAACTTCTGGGTGGATCCTTGCTATGTGCTCACCACATCCGAGAACTCTGTGCACGTGTA
CATGTGGGAAGAAGGAGGCCGCCATCCATACCTCAGGAGCTGCTGTCACCTGGAAAACACGTGGCATGATCACACAACAGACAGCTGCAT
CTCCAGTGTGATGTGTGATAATGCAAGCATAGTACTTAGGGTGAGGAAAGTAAGTGACTCCAGCATTCTGGTGATGTATTCTTTGAATAC

>In-frame_ENST00000424300_ENST00000415155_TCGA-BR-8364-01A_QRICH1_chr3_49114142_-_FBXW12_chr3_48415038_length(amino acids)=388AA_start in transcript=637_stop in transcript=1803
MKWLGLCLNLPVQSPPVFSHKPSKNSRSRFSSRSRFRSLSLQRWDCSNFTNQHLGTHTWKQFFLHQRRKELRLALAQPHNFIYKVTKNIA
FETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTL
PQVFLTESLLRPSEGSVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIW
MGASDGYMIVFTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISS

--------------------------------------------------------------
>In-frame_ENST00000424300_ENST00000445170_TCGA-BR-8364-01A_QRICH1_chr3_49114142_-_FBXW12_chr3_48415038_length(transcript)=2042nt_BP=747nt
CGCGTTCCCGGCCCGGATATCTCTGCTCTAGGAGCTGTGGCCCGTGGGCAACCGCGGCTTTCTGGAGCGCGCGCCCGTGACGACCCCCAG
TTTTGGGGCGCGCGCTCTGATATCGGGTGGCGGTGCTGCCTCGAGAGCGCGCAGGAGGCTTCTGCTGAGCAGAGGGCCGGCCGCGGCTCG
TTGCGCTGGGAAGGTTGAGGATTGGGTCCTTTCTGGTCTGGTGACGTTCCCGGGCATCCGTGGCCTCGGCCTGGAGAGAAACCAACCAGC
TTTGCTGTCTGGCTTGCGGTTCCGCTCCTCTGTGAGGGGGGCGAGATTGCCCGTTCTCCTCGAAGAATGCCGTTACTTGAGGCCCAAAAT
ATTAGAAGTCTTAAGAACTCAGGACAAGCAGCAGAAATACATGCAACATGGTGACTGGAACCCTAAGGACTCTGCAATATGAATAATTCC
CTAGAGAACACCATCTCCTTTGAAGAGTACATCCGAGTAAAGGCACGGTCTGTCCCGCAACACAGGATGAAGGAATTTCTGGACTCACTG
GCCTCTAAGGGGCCAGAAGCCCTTCAGGAGTTCCAGCAGACAGCCACCACTACCATGGTGTACCAACAGGGTGGGAACTGCATATACACA
GACAGCACTGAAGTGGCTGGGTCTTTGCTTGAACTTGCCTGTCCAGTCACCACCAGTGTTCAGCCACAAACCCAGCAAGAACAGCAGATC
CAGGTTCAGCAGCCGCAGCAGGTTCAGGTCACTATCTCTGCAGAGATGGGACTGCAGCAACTTCACCAATCAACACCTGGGCACACACAC
ATGGAAGCAATTTTTCCTGCATCAAAGAAGGAAGGAGCTTCGGTTGGCATTGGCACAGCCGCATAACTTTATCTACAAAGTAACTAAGAA
CATCGCATTTGAGACGGAGTTGGCTTATCTCTCAGGAAATAGACTTACAGTGGATGAACAGGAGAAATCAATCATTTGTAGTGTATCTCC
AAAGCAAGAGCTTTGTGCCTGGGATGTGCAAGAGGGTACCATGATCTGGTCAAGCCCAGTCCAGGAGTTCCATTTCTCAAATCTGGTAAC
CCTCCCTCAGATGCATCTCGCCATCACTATGGATCGGAAAAAAACTATCAAAGTGTGGAACTGTCAGGACAGGGACGCTCTGGCTGTTCT
CCCCATGCCACAGCCCTGTTATTGCATGGAAGCCTATCTTACAAAGGATGGCCCATTCCTGATGGTTGGCGATGCTGCAGGTGACATCTA
CACATTTACACTGCCTGGGTTAAGAGATGTTTCTAAAGTTACTGCATTTCAATATGGTATTGTACTTCTACACTGCTCTCCTGACAAGAA
ATGGGTATTTGCATGTGGGACATACAGTCGTACCTTGCCACAGGTATTCCTCACAGAGTCCTTACTGAGACCATCAGAAGGCAGTGTTCC
TCTGTCTACCTTTCTCCCACATAAATTATGTGCCAGCGCCTGCTGGACCCCAAAGGTGAAAAACAGGATAACACTGATGTCCCAAAGTAG
CACTGGAAAAAAGACAGAATTTATCACCTTTGATCTAACAACCAAGAAGACTGGAGGCCAAACAGTCATCCAAGCATATGAGATCGCAAG
TTTCCAGGTGGCAGCTCATCTGAAGTGCCCTATCTGGATGGGAGCCAGTGATGGATATATGATTGTCTTTACCAGTGGACCATACTTGTT
ACTCTTCAGCATCACTGGCTTCCTGCTGCAACGATTTGAGGACCATCAGGCAGCCATCAACAACTTCTGGGTGGATCCTTGCTATGTGCT
CACCACATCCGAGAACTCTGTGCACGTGTACATGTGGGAAGAAGGAGGCCGCCATCCATACCTCAGGAGCTGCTGTCACCTGGAAAACAC
GTGGCATGATCACACAACAGACAGCTGCATCTCCAGTGTGATGTGTGATAATGCAAGCATAGTACTTAGGGTGAGGAAAGTAAGTGACTC

>In-frame_ENST00000424300_ENST00000445170_TCGA-BR-8364-01A_QRICH1_chr3_49114142_-_FBXW12_chr3_48415038_length(amino acids)=458AA_start in transcript=637_stop in transcript=2013
MKWLGLCLNLPVQSPPVFSHKPSKNSRSRFSSRSRFRSLSLQRWDCSNFTNQHLGTHTWKQFFLHQRRKELRLALAQPHNFIYKVTKNIA
FETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPM
PQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLS
TFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLF
SITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISSVMCDNASIVLRVRKVSDSSI

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for QRICH1-FBXW12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for QRICH1-FBXW12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for QRICH1-FBXW12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneQRICH1C3714756Intellectual Disability1GENOMICS_ENGLAND
HgeneQRICH1C4693824VERVERI-BRADY SYNDROME1GENOMICS_ENGLAND