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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:RAB11A-PPP6R3 (FusionGDB2 ID:70675)

Fusion Gene Summary for RAB11A-PPP6R3

Fusion gene summary

Fusion gene information	Fusion gene name: RAB11A-PPP6R3
	Fusion gene ID: 70675
		Hgene	Tgene
	Gene symbol	RAB11A	PPP6R3
	Gene ID	8766	55291
	Gene name	RAB11A, member RAS oncogene family	protein phosphatase 6 regulatory subunit 3
	Synonyms	YL8	C11orf23\|PP6R3\|SAP190\|SAPL\|SAPLa\|SAPS3
	Cytomap	15q22.31	11q13.2
	Type of gene	protein-coding	protein-coding
	Description	ras-related protein Rab-11ARAB 11A, member oncogene familyrab-11	serine/threonine-protein phosphatase 6 regulatory subunit 3SAPS domain family, member 3sporulation-induced transcript 4-associated protein SAPL
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000563580, ENST00000564910, ENST00000261890, ENST00000565075, ENST00000435304, ENST00000569896,	ENST00000393799, ENST00000530427, ENST00000393800, ENST00000534534, ENST00000524845, ENST00000265637, ENST00000524904, ENST00000393801, ENST00000265636, ENST00000529710, ENST00000527403,
Fusion gene scores	* DoF score	6 X 7 X 3=126	28 X 32 X 13=11648
	# samples	7	38
	** MAII score	log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(38/11648*10)=-4.93793903186775 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RAB11A [Title/Abstract] AND PPP6R3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RAB11A(66161963)-PPP6R3(68377372), # samples:3
Anticipated loss of major functional domain due to fusion event.	RAB11A-PPP6R3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. RAB11A-PPP6R3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RAB11A	GO:0016192	vesicle-mediated transport	17462998\|19542231
Hgene	RAB11A	GO:0072659	protein localization to plasma membrane	17082457
Tgene	PPP6R3	GO:0043666	regulation of phosphoprotein phosphatase activity	16716191

Fusion gene breakpoints across RAB11A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PPP6R3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	CESC	TCGA-ZJ-A8QR-01A	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
ChimerDB4	CESC	TCGA-ZJ-A8QR	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
ChimerDB4	CESC	TCGA-ZJ-A8QR-01A	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
ChimerDB4	CESC	TCGA-ZJ-A8QR-01A	RAB11A	chr15	66161963	-	PPP6R3	chr11	68377372	+
ChimerDB4	CESC	TCGA-ZJ-A8QR-01A	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+

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Fusion Gene ORF analysis for RAB11A-PPP6R3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000563580	ENST00000393799	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
intron-intron	ENST00000563580	ENST00000530427	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
intron-intron	ENST00000563580	ENST00000393800	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
intron-intron	ENST00000563580	ENST00000534534	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
intron-intron	ENST00000563580	ENST00000524845	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
intron-intron	ENST00000563580	ENST00000265637	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
intron-intron	ENST00000563580	ENST00000524904	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
intron-intron	ENST00000563580	ENST00000393801	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
intron-intron	ENST00000563580	ENST00000265636	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
intron-intron	ENST00000563580	ENST00000529710	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
intron-intron	ENST00000563580	ENST00000527403	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
Frame-shift	ENST00000564910	ENST00000393799	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000564910	ENST00000530427	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000564910	ENST00000393800	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000564910	ENST00000534534	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000564910	ENST00000524845	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000564910	ENST00000265637	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000564910	ENST00000524904	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000564910	ENST00000393801	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000564910	ENST00000265636	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000564910	ENST00000529710	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000564910	ENST00000527403	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
Frame-shift	ENST00000261890	ENST00000393799	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000261890	ENST00000530427	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000261890	ENST00000393800	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000261890	ENST00000534534	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000261890	ENST00000524845	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000261890	ENST00000265637	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000261890	ENST00000524904	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000261890	ENST00000393801	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000261890	ENST00000265636	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000261890	ENST00000529710	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000261890	ENST00000527403	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
Frame-shift	ENST00000565075	ENST00000393799	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000565075	ENST00000530427	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000565075	ENST00000393800	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000565075	ENST00000534534	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000565075	ENST00000524845	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000565075	ENST00000265637	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000565075	ENST00000524904	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000565075	ENST00000393801	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000565075	ENST00000265636	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000565075	ENST00000529710	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000565075	ENST00000527403	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
Frame-shift	ENST00000435304	ENST00000393799	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000435304	ENST00000530427	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000435304	ENST00000393800	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000435304	ENST00000534534	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000435304	ENST00000524845	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000435304	ENST00000265637	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000435304	ENST00000524904	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000435304	ENST00000393801	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000435304	ENST00000265636	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000435304	ENST00000529710	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000435304	ENST00000527403	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
Frame-shift	ENST00000569896	ENST00000393799	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000569896	ENST00000530427	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000569896	ENST00000393800	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000569896	ENST00000534534	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000569896	ENST00000524845	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000569896	ENST00000265637	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000569896	ENST00000524904	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000569896	ENST00000393801	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000569896	ENST00000265636	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000569896	ENST00000529710	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
5CDS-intron	ENST00000569896	ENST00000527403	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377372	+
intron-3CDS	ENST00000563580	ENST00000393799	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
intron-intron	ENST00000563580	ENST00000530427	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
intron-intron	ENST00000563580	ENST00000393800	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
intron-intron	ENST00000563580	ENST00000534534	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
intron-intron	ENST00000563580	ENST00000524845	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
intron-intron	ENST00000563580	ENST00000265637	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
intron-intron	ENST00000563580	ENST00000524904	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
intron-intron	ENST00000563580	ENST00000393801	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
intron-intron	ENST00000563580	ENST00000265636	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
intron-intron	ENST00000563580	ENST00000529710	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
intron-intron	ENST00000563580	ENST00000527403	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
Frame-shift	ENST00000564910	ENST00000393799	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000564910	ENST00000530427	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000564910	ENST00000393800	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000564910	ENST00000534534	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000564910	ENST00000524845	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000564910	ENST00000265637	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000564910	ENST00000524904	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000564910	ENST00000393801	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000564910	ENST00000265636	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000564910	ENST00000529710	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000564910	ENST00000527403	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
Frame-shift	ENST00000261890	ENST00000393799	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000261890	ENST00000530427	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000261890	ENST00000393800	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000261890	ENST00000534534	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000261890	ENST00000524845	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000261890	ENST00000265637	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000261890	ENST00000524904	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000261890	ENST00000393801	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000261890	ENST00000265636	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000261890	ENST00000529710	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000261890	ENST00000527403	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
Frame-shift	ENST00000565075	ENST00000393799	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000565075	ENST00000530427	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000565075	ENST00000393800	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000565075	ENST00000534534	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000565075	ENST00000524845	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000565075	ENST00000265637	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000565075	ENST00000524904	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000565075	ENST00000393801	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000565075	ENST00000265636	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000565075	ENST00000529710	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000565075	ENST00000527403	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
Frame-shift	ENST00000435304	ENST00000393799	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000435304	ENST00000530427	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000435304	ENST00000393800	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000435304	ENST00000534534	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000435304	ENST00000524845	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000435304	ENST00000265637	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000435304	ENST00000524904	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000435304	ENST00000393801	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000435304	ENST00000265636	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000435304	ENST00000529710	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000435304	ENST00000527403	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
Frame-shift	ENST00000569896	ENST00000393799	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000569896	ENST00000530427	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000569896	ENST00000393800	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000569896	ENST00000534534	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000569896	ENST00000524845	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000569896	ENST00000265637	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000569896	ENST00000524904	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000569896	ENST00000393801	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000569896	ENST00000265636	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000569896	ENST00000529710	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000569896	ENST00000527403	RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+
intron-3CDS	ENST00000563580	ENST00000393799	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
intron-intron	ENST00000563580	ENST00000530427	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
intron-intron	ENST00000563580	ENST00000393800	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
intron-intron	ENST00000563580	ENST00000534534	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
intron-intron	ENST00000563580	ENST00000524845	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
intron-intron	ENST00000563580	ENST00000265637	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
intron-intron	ENST00000563580	ENST00000524904	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
intron-intron	ENST00000563580	ENST00000393801	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
intron-intron	ENST00000563580	ENST00000265636	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
intron-intron	ENST00000563580	ENST00000529710	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
intron-intron	ENST00000563580	ENST00000527403	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
Frame-shift	ENST00000564910	ENST00000393799	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000564910	ENST00000530427	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000564910	ENST00000393800	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000564910	ENST00000534534	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000564910	ENST00000524845	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000564910	ENST00000265637	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000564910	ENST00000524904	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000564910	ENST00000393801	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000564910	ENST00000265636	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000564910	ENST00000529710	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000564910	ENST00000527403	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
Frame-shift	ENST00000261890	ENST00000393799	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000261890	ENST00000530427	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000261890	ENST00000393800	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000261890	ENST00000534534	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000261890	ENST00000524845	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000261890	ENST00000265637	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000261890	ENST00000524904	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000261890	ENST00000393801	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000261890	ENST00000265636	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000261890	ENST00000529710	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000261890	ENST00000527403	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
Frame-shift	ENST00000565075	ENST00000393799	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000565075	ENST00000530427	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000565075	ENST00000393800	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000565075	ENST00000534534	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000565075	ENST00000524845	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000565075	ENST00000265637	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000565075	ENST00000524904	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000565075	ENST00000393801	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000565075	ENST00000265636	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000565075	ENST00000529710	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000565075	ENST00000527403	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
Frame-shift	ENST00000435304	ENST00000393799	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000435304	ENST00000530427	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000435304	ENST00000393800	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000435304	ENST00000534534	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000435304	ENST00000524845	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000435304	ENST00000265637	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000435304	ENST00000524904	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000435304	ENST00000393801	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000435304	ENST00000265636	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000435304	ENST00000529710	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000435304	ENST00000527403	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
Frame-shift	ENST00000569896	ENST00000393799	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000569896	ENST00000530427	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000569896	ENST00000393800	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000569896	ENST00000534534	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000569896	ENST00000524845	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000569896	ENST00000265637	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000569896	ENST00000524904	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000569896	ENST00000393801	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000569896	ENST00000265636	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000569896	ENST00000529710	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+
5CDS-intron	ENST00000569896	ENST00000527403	RAB11A	chr15	66161962	+	PPP6R3	chr11	68377371	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for RAB11A-PPP6R3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+	3.90E-06	0.99999607
RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+	3.90E-06	0.99999607
RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+	3.90E-06	0.99999607
RAB11A	chr15	66161963	+	PPP6R3	chr11	68377371	+	3.90E-06	0.99999607

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RAB11A-PPP6R3

Go to
FGviewer for the breakpoints of :-:
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for RAB11A-PPP6R3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for RAB11A-PPP6R3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for RAB11A-PPP6R3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for RAB11A-PPP6R3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	RAB11A	C0263454	Chloracne	1	CTD_human
Hgene	RAB11A	C0557874	Global developmental delay	1	GENOMICS_ENGLAND
Hgene	RAB11A	C3714756	Intellectual Disability	1	GENOMICS_ENGLAND