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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RAB11FIP1-ZDHHC24 (FusionGDB2 ID:70698)

Fusion Gene Summary for RAB11FIP1-ZDHHC24

check button Fusion gene summary
Fusion gene informationFusion gene name: RAB11FIP1-ZDHHC24
Fusion gene ID: 70698
HgeneTgene
Gene symbol

RAB11FIP1

ZDHHC24

Gene ID

80223

254359

Gene nameRAB11 family interacting protein 1zinc finger DHHC-type containing 24
SynonymsNOEL1A|RCP|rab11-FIP1-
Cytomap

8p11.23

11q13.2

Type of geneprotein-codingprotein-coding
Descriptionrab11 family-interacting protein 1RAB11 coupling proteinRAB11 family interacting protein 1 (class I)Rab effector proteinRab-interacting recycling proteinprobable palmitoyltransferase ZDHHC24DHHC-24zinc finger DHHC domain-containing protein 24zinc finger, DHHC domain containing 24
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000287263, ENST00000330843, 
ENST00000522727, ENST00000523182, 
ENST00000524118, 		ENST00000526986, 
ENST00000310442, ENST00000525925, 
Fusion gene scores* DoF score10 X 14 X 4=5604 X 4 X 2=32
# samples 124
** MAII scorelog2(12/560*10)=-2.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RAB11FIP1 [Title/Abstract] AND ZDHHC24 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRAB11FIP1(37756589)-ZDHHC24(66294477), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAB11FIP1

GO:0070164

negative regulation of adiponectin secretion

24040321


check buttonFusion gene breakpoints across RAB11FIP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ZDHHC24 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A1KT-01ARAB11FIP1chr8

37756589

-ZDHHC24chr11

66294477

-
ChimerDB4BRCATCGA-AO-A1KT-01ARAB11FIP1chr8

37756589

-ZDHHC24chr11

66294477

-


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Fusion Gene ORF analysis for RAB11FIP1-ZDHHC24

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000287263ENST00000526986RAB11FIP1chr8

37756589

-ZDHHC24chr11

66294477

-
5CDS-intronENST00000287263ENST00000310442RAB11FIP1chr8

37756589

-ZDHHC24chr11

66294477

-
5CDS-intronENST00000287263ENST00000525925RAB11FIP1chr8

37756589

-ZDHHC24chr11

66294477

-
In-frameENST00000330843ENST00000526986RAB11FIP1chr8

37756589

-ZDHHC24chr11

66294477

-
5CDS-intronENST00000330843ENST00000310442RAB11FIP1chr8

37756589

-ZDHHC24chr11

66294477

-
5CDS-intronENST00000330843ENST00000525925RAB11FIP1chr8

37756589

-ZDHHC24chr11

66294477

-
intron-3CDSENST00000522727ENST00000526986RAB11FIP1chr8

37756589

-ZDHHC24chr11

66294477

-
intron-intronENST00000522727ENST00000310442RAB11FIP1chr8

37756589

-ZDHHC24chr11

66294477

-
intron-intronENST00000522727ENST00000525925RAB11FIP1chr8

37756589

-ZDHHC24chr11

66294477

-
intron-3CDSENST00000523182ENST00000526986RAB11FIP1chr8

37756589

-ZDHHC24chr11

66294477

-
intron-intronENST00000523182ENST00000310442RAB11FIP1chr8

37756589

-ZDHHC24chr11

66294477

-
intron-intronENST00000523182ENST00000525925RAB11FIP1chr8

37756589

-ZDHHC24chr11

66294477

-
intron-3CDSENST00000524118ENST00000526986RAB11FIP1chr8

37756589

-ZDHHC24chr11

66294477

-
intron-intronENST00000524118ENST00000310442RAB11FIP1chr8

37756589

-ZDHHC24chr11

66294477

-
intron-intronENST00000524118ENST00000525925RAB11FIP1chr8

37756589

-ZDHHC24chr11

66294477

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000287263RAB11FIP1chr837756589-ENST00000526986ZDHHC24chr1166294477-8533975101170
ENST00000330843RAB11FIP1chr837756589-ENST00000526986ZDHHC24chr1166294477-8403844970166

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000287263ENST00000526986RAB11FIP1chr837756589-ZDHHC24chr1166294477-0.179355930.8206441
ENST00000330843ENST00000526986RAB11FIP1chr837756589-ZDHHC24chr1166294477-0.146355750.8536443

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Fusion Genomic Features for RAB11FIP1-ZDHHC24


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RAB11FIP1-ZDHHC24


check button Go to

FGviewer for the breakpoints of chr8:37756589-chr11:66294477

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAB11FIP1chr8:37756589chr11:66294477ENST00000287263-151_126123.66666666666667650.0DomainC2
HgeneRAB11FIP1chr8:37756589chr11:66294477ENST00000330843-161_126123.666666666666671284.0DomainC2
TgeneZDHHC24chr8:37756589chr11:66294477ENST0000031044203140_2220285.0Compositional biasNote=Leu-rich
TgeneZDHHC24chr8:37756589chr11:66294477ENST000003104420394_1440285.0DomainDHHC
TgeneZDHHC24chr8:37756589chr11:66294477ENST0000031044203159_1660285.0Topological domainExtracellular
TgeneZDHHC24chr8:37756589chr11:66294477ENST0000031044203188_2010285.0Topological domainCytoplasmic
TgeneZDHHC24chr8:37756589chr11:66294477ENST00000310442031_180285.0Topological domainCytoplasmic
TgeneZDHHC24chr8:37756589chr11:66294477ENST0000031044203223_2840285.0Topological domainExtracellular
TgeneZDHHC24chr8:37756589chr11:66294477ENST000003104420340_520285.0Topological domainExtracellular
TgeneZDHHC24chr8:37756589chr11:66294477ENST000003104420374_1370285.0Topological domainCytoplasmic
TgeneZDHHC24chr8:37756589chr11:66294477ENST0000031044203138_1580285.0TransmembraneHelical
TgeneZDHHC24chr8:37756589chr11:66294477ENST0000031044203167_1870285.0TransmembraneHelical
TgeneZDHHC24chr8:37756589chr11:66294477ENST000003104420319_390285.0TransmembraneHelical
TgeneZDHHC24chr8:37756589chr11:66294477ENST0000031044203202_2220285.0TransmembraneHelical
TgeneZDHHC24chr8:37756589chr11:66294477ENST000003104420353_730285.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAB11FIP1chr8:37756589chr11:66294477ENST00000287263-15209_218123.66666666666667650.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37756589chr11:66294477ENST00000287263-15556_609123.66666666666667650.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37756589chr11:66294477ENST00000330843-16209_218123.666666666666671284.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37756589chr11:66294477ENST00000330843-16556_609123.666666666666671284.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37756589chr11:66294477ENST00000524118-13209_2180440.0Compositional biasNote=Poly-Lys
HgeneRAB11FIP1chr8:37756589chr11:66294477ENST00000524118-13556_6090440.0Compositional biasNote=Ser-rich
HgeneRAB11FIP1chr8:37756589chr11:66294477ENST00000287263-151211_1273123.66666666666667650.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37756589chr11:66294477ENST00000330843-161211_1273123.666666666666671284.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37756589chr11:66294477ENST00000524118-131211_12730440.0DomainFIP-RBD
HgeneRAB11FIP1chr8:37756589chr11:66294477ENST00000524118-131_1260440.0DomainC2


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Fusion Gene Sequence for RAB11FIP1-ZDHHC24


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000287263_ENST00000526986_TCGA-AO-A1KT-01A_RAB11FIP1_chr8_37756589_-_ZDHHC24_chr11_66294477_length(transcript)=853nt_BP=397nt
CTCGCTTCTGGAGTGTTATCGTCACCATGTCCCTAATGGTCTCGGCTGGCCGGGGCCTGGGGGCCGTGTGGTCCCCAACCCACGTGCAGG
TGACGGTGCTGCAGGCGCGGGGCCTGCGGGCCAAGGGCCCCGGGGGCACGAGCGACGCGTACGCGGTGATCCAGGTGGGCAAGGAGAAGT
ACGCCACCTCCGTGTCGGAGCGCAGCCTGGGCGCGCCCGTGTGGCGCGAGGAGGCCACCTTCGAGCTGCCATCGCTGCTGTCCTCCGGAC
CCGCGGCCGCCGCCACCCTGCAGCTCACCGTGCTGCACCGCGCGCTGCTCGGCCTCGACAAGTTCCTGGGCCGCGCCGAGGTGGACCTGC
GGGATCTGCACCGCGACCAGGGCCGCAGGAAGACGCACACCTTCCAGCCTGAGGAACAGTGATTTGCAGGCAACGTGTACCTCCTAGGCT
GTCCCTGGATTTGCAGAGCCTTAAAGCCCACTCTCATCTTGCAAGCCTCTGAAGCCACCAGTTTTCTGAGATGTTCCTCCCGGCCCCGGA
GACCACGGATGTGGCTACCTTCTCAGAATATAGATGTTTCCATTGCGGCAGGCCGCGGCAAGCCGGAACTCAACATCAAACTGGCCAGAA
ACCTCTAGGAAGACGGGGACGCTGGGAAGGCTCATCTGCAAACAAGAAGCGCAAACACTCCAATTTCTCTGGAGCCCCCGTCCCTCCCTG
CCCTGTCAGTAACTCCTCTGAGTGAGTGCCTGGTCTAAAGTCCCAATCTCCTCACTTACACCCAGTTTAAACTCATACAGTTTTTCAGGA

>In-frame_ENST00000287263_ENST00000526986_TCGA-AO-A1KT-01A_RAB11FIP1_chr8_37756589_-_ZDHHC24_chr11_66294477_length(amino acids)=170AA_start in transcript=510_stop in transcript=1
MVASEACKMRVGFKALQIQGQPRRYTLPANHCSSGWKVCVFLRPWSRCRSRRSTSARPRNLSRPSSARCSTVSCRVAAAAGPEDSSDGSS

--------------------------------------------------------------
>In-frame_ENST00000330843_ENST00000526986_TCGA-AO-A1KT-01A_RAB11FIP1_chr8_37756589_-_ZDHHC24_chr11_66294477_length(transcript)=840nt_BP=384nt
TGTTATCGTCACCATGTCCCTAATGGTCTCGGCTGGCCGGGGCCTGGGGGCCGTGTGGTCCCCAACCCACGTGCAGGTGACGGTGCTGCA
GGCGCGGGGCCTGCGGGCCAAGGGCCCCGGGGGCACGAGCGACGCGTACGCGGTGATCCAGGTGGGCAAGGAGAAGTACGCCACCTCCGT
GTCGGAGCGCAGCCTGGGCGCGCCCGTGTGGCGCGAGGAGGCCACCTTCGAGCTGCCATCGCTGCTGTCCTCCGGACCCGCGGCCGCCGC
CACCCTGCAGCTCACCGTGCTGCACCGCGCGCTGCTCGGCCTCGACAAGTTCCTGGGCCGCGCCGAGGTGGACCTGCGGGATCTGCACCG
CGACCAGGGCCGCAGGAAGACGCACACCTTCCAGCCTGAGGAACAGTGATTTGCAGGCAACGTGTACCTCCTAGGCTGTCCCTGGATTTG
CAGAGCCTTAAAGCCCACTCTCATCTTGCAAGCCTCTGAAGCCACCAGTTTTCTGAGATGTTCCTCCCGGCCCCGGAGACCACGGATGTG
GCTACCTTCTCAGAATATAGATGTTTCCATTGCGGCAGGCCGCGGCAAGCCGGAACTCAACATCAAACTGGCCAGAAACCTCTAGGAAGA
CGGGGACGCTGGGAAGGCTCATCTGCAAACAAGAAGCGCAAACACTCCAATTTCTCTGGAGCCCCCGTCCCTCCCTGCCCTGTCAGTAAC
TCCTCTGAGTGAGTGCCTGGTCTAAAGTCCCAATCTCCTCACTTACACCCAGTTTAAACTCATACAGTTTTTCAGGAGGGAAACTTGGGG

>In-frame_ENST00000330843_ENST00000526986_TCGA-AO-A1KT-01A_RAB11FIP1_chr8_37756589_-_ZDHHC24_chr11_66294477_length(amino acids)=166AA_start in transcript=497_stop in transcript=0
MVASEACKMRVGFKALQIQGQPRRYTLPANHCSSGWKVCVFLRPWSRCRSRRSTSARPRNLSRPSSARCSTVSCRVAAAAGPEDSSDGSS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RAB11FIP1-ZDHHC24


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RAB11FIP1-ZDHHC24


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RAB11FIP1-ZDHHC24


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource