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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RAB33B-NAA15 (FusionGDB2 ID:70864)

Fusion Gene Summary for RAB33B-NAA15

check button Fusion gene summary
Fusion gene informationFusion gene name: RAB33B-NAA15
Fusion gene ID: 70864
HgeneTgene
Gene symbol

RAB33B

NAA15

Gene ID

83452

80155

Gene nameRAB33B, member RAS oncogene familyN-alpha-acetyltransferase 15, NatA auxiliary subunit
SynonymsSMC2Ga19|MRD50|NARG1|NAT1P|NATH|TBDN|TBDN100
Cytomap

4q31.1

4q31.1

Type of geneprotein-codingprotein-coding
Descriptionras-related protein Rab-33BN-alpha-acetyltransferase 15, NatA auxiliary subunitN-terminal acetyltransferaseNMDA receptor regulated 1NMDA receptor-regulated protein 1gastric cancer antigen Ga19protein tubedown-1transcriptional coactivator tubedown-100tubedown-1
Modification date2020031320200313
UniProtAcc.

Q9BXJ9

Ensembl transtripts involved in fusion geneENST00000305626, ENST00000507271, 
ENST00000296543, ENST00000398947, 
ENST00000480277, ENST00000515576, 
Fusion gene scores* DoF score3 X 2 X 3=1814 X 11 X 8=1232
# samples 315
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(15/1232*10)=-3.03796785019902
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAB33B [Title/Abstract] AND NAA15 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRAB33B(140375598)-NAA15(140255328), # samples:3
NAA15(140291558)-RAB33B(140393840), # samples:1
NAA15(140272765)-RAB33B(140393840), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNAA15

GO:0006474

N-terminal protein amino acid acetylation

15496142

TgeneNAA15

GO:0045893

positive regulation of transcription, DNA-templated

12145306


check buttonFusion gene breakpoints across RAB33B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NAA15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-N8-A4PL-01ARAB33Bchr4

140375598

+NAA15chr4

140255328

+
ChimerDB4UCSTCGA-N8-A4PLRAB33Bchr4

140375598

+NAA15chr4

140255328

+
ChimerDB4UCSTCGA-N8-A4PL-01ARAB33Bchr4

140375598

-NAA15chr4

140255328

+


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Fusion Gene ORF analysis for RAB33B-NAA15

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000305626ENST00000296543RAB33Bchr4

140375598

+NAA15chr4

140255328

+
In-frameENST00000305626ENST00000398947RAB33Bchr4

140375598

+NAA15chr4

140255328

+
5CDS-intronENST00000305626ENST00000480277RAB33Bchr4

140375598

+NAA15chr4

140255328

+
5CDS-intronENST00000305626ENST00000515576RAB33Bchr4

140375598

+NAA15chr4

140255328

+
intron-3CDSENST00000507271ENST00000296543RAB33Bchr4

140375598

+NAA15chr4

140255328

+
intron-3CDSENST00000507271ENST00000398947RAB33Bchr4

140375598

+NAA15chr4

140255328

+
intron-intronENST00000507271ENST00000480277RAB33Bchr4

140375598

+NAA15chr4

140255328

+
intron-intronENST00000507271ENST00000515576RAB33Bchr4

140375598

+NAA15chr4

140255328

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000305626RAB33Bchr4140375598+ENST00000296543NAA15chr4140255328+64836383713184937
ENST00000305626RAB33Bchr4140375598+ENST00000398947NAA15chr4140255328+64666383713181936

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000305626ENST00000296543RAB33Bchr4140375598+NAA15chr4140255328+0.0001187930.99988115
ENST00000305626ENST00000398947RAB33Bchr4140375598+NAA15chr4140255328+0.0001197750.9998802

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Fusion Genomic Features for RAB33B-NAA15


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RAB33Bchr4140375598+NAA15chr4140255327+1.15E-081
RAB33Bchr4140375598+NAA15chr4140255327+1.15E-081
RAB33Bchr4140375598+NAA15chr4140255327+1.15E-081
RAB33Bchr4140375598+NAA15chr4140255327+1.15E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RAB33B-NAA15


check button Go to

FGviewer for the breakpoints of chr4:140375598-chr4:140255328

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NAA15

Q9BXJ9

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter. {ECO:0000269|PubMed:11687548, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15496142}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAB33Bchr4:140375598chr4:140255328ENST00000305626+1239_4683.0230.0Nucleotide bindingGTP
TgeneNAA15chr4:140375598chr4:140255328ENST00000296543020629_63218.0867.0Compositional biasNote=Poly-Asp
TgeneNAA15chr4:140375598chr4:140255328ENST00000296543020612_62918.0867.0MotifBipartite nuclear localization signal
TgeneNAA15chr4:140375598chr4:140255328ENST00000296543020148_18418.0867.0RepeatNote=TPR 3
TgeneNAA15chr4:140375598chr4:140255328ENST00000296543020224_25718.0867.0RepeatNote=TPR 4
TgeneNAA15chr4:140375598chr4:140255328ENST00000296543020374_40718.0867.0RepeatNote=TPR 5
TgeneNAA15chr4:140375598chr4:140255328ENST00000296543020409_44118.0867.0RepeatNote=TPR 6
TgeneNAA15chr4:140375598chr4:140255328ENST0000029654302046_7918.0867.0RepeatNote=TPR 1
TgeneNAA15chr4:140375598chr4:140255328ENST00000296543020485_51818.0867.0RepeatNote=TPR 7
TgeneNAA15chr4:140375598chr4:140255328ENST00000296543020672_70518.0867.0RepeatNote=TPR 8
TgeneNAA15chr4:140375598chr4:140255328ENST0000029654302080_11318.0867.0RepeatNote=TPR 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAB33Bchr4:140375598chr4:140255328ENST00000305626+12148_15183.0230.0Nucleotide bindingGTP
HgeneRAB33Bchr4:140375598chr4:140255328ENST00000305626+1288_9283.0230.0Nucleotide bindingGTP


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Fusion Gene Sequence for RAB33B-NAA15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000305626_ENST00000296543_TCGA-N8-A4PL-01A_RAB33B_chr4_140375598_+_NAA15_chr4_140255328_length(transcript)=6483nt_BP=638nt
GCTTCCTCCAGAGGGCGGGAACCTTGGACGTGGCGGGGCTGGGTCAGTCAGGGCGCTGGGCCCAGCCTCTCTGCAGGCTGGCCTTCCGCG
CTGCCGTGAAGCCCCCGACAGGTCCCACGCCTGCCTAGGTAGACCGGCGCCAGCCCGAGTGACGCCTGGCGTGTGGCCGCGGGCAGGCGG
CTCCGTGCGGCGGGGCGGGCGGGTGCCACACCTGTGCGGGCAAGGGCGGGGCGGGAAGGTGCGCAGGCGCGCTCGGGGCTGGTGGGCGGT
GGCTCCTGGGAAGTTGCGCAGCCGAACTGGCCGGCTGGGCGCGCGCTCTTGCGGTGGCGTAATCTCTCAGCCTTTCTGTGTCTCCTTTCC
TCCGCCTCAGTTTGGGGCGGGTCGGGGGAATGGCTGAGGAGATGGAGTCGTCGCTCGAGGCAAGCTTTTCGTCCAGCGGGGCAGTGTCAG
GGGCCTCAGGGTTTTTGCCTCCTGCCCGCTCCCGCATCTTCAAGATAATCGTGATCGGCGACTCCAATGTGGGCAAGACATGCCTGACCT
ACCGCTTCTGCGCTGGCCGCTTCCCCGACCGCACCGAGGCCACGATAGGGGTGGATTTCCGAGAACGAGCGGTGGAGATTGATGGGGAGC
GCATCAAGAGGTGTTATGAACATAAACAGTATAGAAATGGATTGAAATTCTGTAAACAAATACTTTCTAATCCCAAATTTGCAGAGCATG
GAGAAACCTTGGCTATGAAAGGATTAACATTGAACTGTTTGGGGAAAAAGGAAGAAGCTTATGAATTGGTTCGTAGAGGTTTGAGAAATG
ACTTGAAGAGTCATGTGTGTTGGCACGTTTATGGCCTTCTTCAGAGGTCAGACAAGAAGTATGATGAAGCCATTAAGTGTTACAGAAATG
CACTAAAATGGGATAAAGACAATCTTCAAATCTTAAGGGACCTTTCCTTACTACAGATTCAAATGCGAGATCTTGAGGGTTACAGGGAAA
CGAGGTATCAGTTACTTCAGCTTCGACCTGCGCAGAGAGCATCATGGATTGGTTATGCTATTGCTTACCATTTATTAGAAGATTATGAAA
TGGCAGCAAAGATTTTAGAAGAATTTAGGAAAACACAACAGACATCCCCTGACAAGGTGGATTATGAATATAGTGAACTACTCTTATATC
AGAATCAAGTTCTTCGGGAAGCAGGTCTCTATAGAGAAGCTTTGGAACATCTTTGTACCTATGAAAAGCAGATTTGTGATAAACTTGCTG
TAGAAGAAACCAAAGGGGAACTTCTGTTGCAACTATGTCGTTTGGAAGATGCTGCAGATGTTTATAGAGGATTGCAAGAGAGAAATCCTG
AAAACTGGGCCTATTACAAAGGCTTGGAAAAAGCACTCAAGCCAGCTAATATGTTAGAACGGCTAAAAATTTATGAGGAAGCCTGGACTA
AATATCCCAGGGGACTGGTGCCAAGAAGGCTGCCGTTAAACTTTTTATCTGGTGAGAAGTTTAAAGAATGTTTGGATAAGTTCCTAAGGA
TGAATTTCAGCAAGGGTTGCCCACCAGTCTTCAATACTTTAAGATCATTATACAAAGACAAAGAAAAGGTGGCAATCATAGAAGAGTTAG
TAGTAGGTTATGAAACCTCTCTAAAAAGCTGCCGGTTATTTAACCCCAATGATGATGGAAAGGAGGAACCACCAACCACATTACTTTGGG
TCCAGTACTACTTGGCACAACATTATGACAAAATTGGTCAGCCATCTATTGCTTTGGAGTACATAAATACTGCTATTGAAAGTACACCTA
CATTAATAGAACTCTTTCTCGTGAAAGCTAAAATCTATAAGCATGCTGGAAATATTAAAGAAGCTGCAAGGTGGATGGATGAGGCCCAGG
CCTTGGACACAGCAGACAGATTTATCAACTCCAAATGTGCAAAATACATGCTAAAAGCCAACCTGATTAAAGAAGCTGAAGAAATGTGCT
CAAAGTTTACAAGGGAAGGAACATCAGCGGTAGAGAATTTGAATGAAATGCAGTGCATGTGGTTCCAAACAGAATGTGCCCAGGCTTATA
AAGCAATGAATAAATTTGGTGAAGCACTTAAGAAATGTCATGAGATTGAGAGACATTTTATAGAAATCACTGATGACCAGTTTGACTTTC
ATACATACTGTATGAGGAAGATTACCCTTAGATCATATGTGGACTTATTAAAACTAGAAGATGTACTTCGACAGCATCCATTTTACTTCA
AGGCAGCAAGAATTGCTATAGAGATCTATTTGAAGCTTCATGACAACCCCCTTACAGATGAGAATAAAGAACACGAAGCTGATACAGCAA
ACATGTCTGACAAAGAGCTAAAGAAGCTACGTAATAAACAAAGAAGAGCTCAAAAGAAAGCCCAGATAGAAGAAGAGAAAAAAAATGCAG
AAAAAGAAAAGCAGCAGAGAAATCAGAAAAAGAAGAAGGATGATGATGATGAGGAGATAGGAGGTCCAAAAGAAGAACTTATTCCAGAGA
AACTGGCCAAGGTTGAAACTCCATTGGAAGAAGCTATTAAATTTTTAACACCGTTGAAGAACTTGGTGAAGAACAAGATAGAGACTCATC
TTTTTGCCTTTGAGATTTACTTTAGGAAAGAAAAGTTTCTTTTGATGCTACAATCAGTAAAGAGGGCATTTGCTATTGATTCTAGTCATC
CCTGGCTTCATGAGTGTATGATTCGTCTCTTTAATACTGCAGTGTGTGAAAGTAAAGATTTATCTGATACAGTTAGAACAGTATTAAAAC
AAGAAATGAATCGTCTTTTTGGAGCAACGAATCCAAAGAATTTTAATGAAACTTTTCTGAAAAGGAATTCTGATTCATTGCCACACAGAT
TATCAGCTGCCAAAATGGTATATTACTTAGATCCTTCTAGTCAGAAGCGAGCTATAGAGTTGGCAACAACACTTGATGAATCTCTCACTA
ACAGAAACCTCCAGACATGTATGGAGGTATTGGAAGCCTTGTATGATGGTAGCCTAGGAGACTGTAAAGAAGCTGCTGAAATTTATAGAG
CAAATTGTCATAAGCTTTTCCCTTATGCTTTGGCTTTCATGCCTCCTGGATATGAAGAGGATATGAAGATCACAGTTAATGGAGATAGTT
CTGCAGAAGCTGAAGAACTGGCCAATGAAATTTGAACATCACTAAACAAGCAAATGGAATGACTTTGGACCATATCTAGTATATAATATT
TTTGTCACGCACCTGCTGCATTGCTCTAACTTACACAGAATGAGAGGAGTAAATGTTCTTGCCTTCAAATAGTGTTTTACGTTTTTTATC
CTGCTGAAAAAGTATATATAAAATATCTAACATTACAGGATAGAGGTTCAGTTTCTTAAAAAATTAAAGCTGCTAAAATTGAGTGGTTAA
AAAAGATACCTTATCCTATTCCTCCCCACCCACCCATGTTTTTAAACTAATTTATATAAAATCTGGAGGCTGTTACAGCTAACAAAGCAG
GTGTGTGGCAGAAATATTACTTTAAATTTGTCTTGTGAGATTTTACTATATCTCAGACAGCATAAATGCTGTTTTAGCACTGGATTCTTT
CACTGAGCACAAAGAGTTGTTGGGGCTTTAGCATCTGACTGATTTTGTTACGGGGTTGATTCTGACCATAGGAAGTATGCAATGTGAATC
ACTATTTACAGAGAAACCTACAACAGATGCTTGATGTTGTAGAAACTGGGACATATAGATACCAAGCAAAATTATAAGAAACCTATAAGG
TGTTCAATACGCTTGTGTTTCCAAAATTCACTGTACATGATCAGTTTGGTGTTCTTGTACCACAGTTTTTAACTGAAGGAACCAGTTGTA
ACAGTCTCAATTTTAACTAAAACTTGAAGAACTAAAACAACAATGCAAACCTTTCAGCATTGTTTGGCCAAACTTGTTAAAACTGTAATG
CAAGAACCAAATGCACTGTGATGTGGCACCAACTAATTAGCAAGCATGAATTTTTCACCCAAGAGTGAAAAAAGGAAAATCTACCATGGC
TTGAAGTTAAAGAGCAGAACTCCTGACTACCATTCTATGACTGATCAAAAGACTAATAGTTAAAAACCTCAGCAGGCCTTGTTCACGATA
TGCAGAAAAAAAAGTGCTGCAGTTTAGATACCTCTGGAATTTTTCCACAGTGTCACAGGTTTGTAATACTTGAAGCCCTACATTTCTAAG
AATATATTTCTTGCTCAGTTGTTTCAGGCAAGCCCAAGACTTTGTAATTTTTAAAGGGCCCAAGATTTTTTTTTTTTTTTTTTTTTTCAA
ATAACAGACCAGCTTCTTTTTCTTGCAGTTACAGATGTAATTTCCTTTTTGTTGTCAAACATAAGGTACCAAATATGATGCAATAAATTG
TTTTGAAAAACAGTTGTGTGAATATTTCAACTAATCTGTGTTGGGCTTCTGTGAAATACACAGGTGGAAACAGAGGTGCAAGCCAGAGGC
AATGTAATATGCTGTAAGGCTAGTGCAGATGGGAGCTTTTTAGAAGGGGCTAAGTGCTGGTGTCAGGGAAATTCCATAATGAAGTAGAAT
GCTGCTCCTGCATTAAGATTTCATTGAGGGCAAGGCTGGTGGCAGGTACTATGAATGTAATTCATAATTTAAAAGGAAAACTAAAAACTA
TTTTGATTTGGGAAAATGAGCCTTAATTTGTTAAACCTATACACTGAGAACTAGCCTCAGGCTTAATATTCTCATTGCATTTGCAAGATC
TGAGCAAATAAGATTAAGTAAAACAAATCAATTGTATATATAATTGACCTTTTTGTGGAACATGTAGTTTATAGAAAGTATACTCTAAAG
GGAATTTGCCGAAGACCTTTTACTGATTGAACAGTTGTGCTACAATCAACTTTTCATAGTACATGACCTGCATTCCACATCTCAGTCTAA
CAGTTTAGTAGTGATGTAAAGAGAAGTACAAACCGAACTCCAGTGCTTTGTTATGTTTTATTAACTGGCCCTGTCTCAGGAACATCTTAA
CAGATGGCAAAAAAACAAAAACTTTTTTTCAACTCCTATGAGTGGCAACTGAAGTTCTTATTGTTGGGAAAGAACACTAGTCCTACCTCT
GCCACTAATGAGGTGTTTGGAGGAGGTACCAGCCATATAATAGGGGGTGTATGTGTGAATTTTGTTTAAACTCTACTGTATATTGAAATG
AAATTCATTTATTTGTCTTGACAATGTTCAAATGATGTAGATTGTCTTAGAATGAATATTCATAAGTACTCAGAACTCTTAAGATGCAGA
TGCCACCCGTGAGGAGCTAAATTCCTAATGTGTATTGTATTCCAACCCAATTTTACTGGAACTATTGAATAAATCTTTTATTTTCTTTCA
GGTTTACTTGATAGTGGATACATTGGTGTCAGAGGACCTTGACTGGGTTCATTTTATGTCCAGACATCACCCCTGAAACACTGTACTGTA
CTATCTTGCTCTGAGTAGTATCAACTGGATCGTCTCATATTTGCCTCATTCATCCTATTAATTTCAAATGATACTGTGGGGGAAAAACAG
GGTTAGAAAAACAAGTGGAAAAAATGGAGTGATGTTGTAATCTAAACAAGTGCCTTATGTTTATTGCTAAGAACTGGTGTTACCAACCCT
TTTGAGAAGAAAGGGTCTCTTGACCTGTATTAACATAGGAAAGTAAAGTTCTTTTTGTTTTTCTTTATATTCAGCTACTCTTGTCATTTC
TCGTTGAAAAACTAAAATCTGACTAGGTTAGTTTACTCAGCTTTAATTAGATAGTTGAGTCATATATTTTCAACATTTTTCTGTATCGTA
TTTATTATGCACAAAAATAAAGTGTGATCTCTAATAGCATGGCTAAAGGTAATGCCAATATTAGTGAATAGCTTTGCTGTGGGCTTTATC
AGGCCCTTGTTTTTCACAGTGTTGTTTGTACTCCATGGTGTATTGCTATTAGAGCTGTGAAATGAAAGCTGTGACTTTATGAAGAGATCA
AAAAAAGTGTGGTCCAGATTCAGGTAGGTTGTGGTAAGTTCAGGGAAGTCTTGTATGATTTCTAAGAATATTTCAGTTACCATGTATAGT
ATTTGGGAAAAGCTGTAATGTAAAATATTGGACTTTGTTGCAAGATAGGTATATACTTGTGTCAGATAATTAAAGCCTTAAATTTTGAAA
TGAATCTTTGAGATTTCAAAGAAAGACTGACCTTTCAAATAGAAGGCGGTCTTTCTATTCTAGCTAATGCCCCACTTCTTTAAGTTATAA
ACAAAGTTTCATGATACCATTCTGCTATCATCTAAACTTTGCTGAACTCTACTGCCAACCTACATTAAAAACAAAGTCCCACGAAATGGC
TGTGTTACACCATAGTGAGCAGAAACTTAAATTTTGTTCTAATTTTGATGGTTGAAAAATTTCAACCTGTAGCAATAAAACATTTTTGGA

>In-frame_ENST00000305626_ENST00000296543_TCGA-N8-A4PL-01A_RAB33B_chr4_140375598_+_NAA15_chr4_140255328_length(amino acids)=937AA_start in transcript=371_stop in transcript=3184
MGRVGGMAEEMESSLEASFSSSGAVSGASGFLPPARSRIFKIIVIGDSNVGKTCLTYRFCAGRFPDRTEATIGVDFRERAVEIDGERIKR
CYEHKQYRNGLKFCKQILSNPKFAEHGETLAMKGLTLNCLGKKEEAYELVRRGLRNDLKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKW
DKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPAQRASWIGYAIAYHLLEDYEMAAKILEEFRKTQQTSPDKVDYEYSELLLYQNQV
LREAGLYREALEHLCTYEKQICDKLAVEETKGELLLQLCRLEDAADVYRGLQERNPENWAYYKGLEKALKPANMLERLKIYEEAWTKYPR
GLVPRRLPLNFLSGEKFKECLDKFLRMNFSKGCPPVFNTLRSLYKDKEKVAIIEELVVGYETSLKSCRLFNPNDDGKEEPPTTLLWVQYY
LAQHYDKIGQPSIALEYINTAIESTPTLIELFLVKAKIYKHAGNIKEAARWMDEAQALDTADRFINSKCAKYMLKANLIKEAEEMCSKFT
REGTSAVENLNEMQCMWFQTECAQAYKAMNKFGEALKKCHEIERHFIEITDDQFDFHTYCMRKITLRSYVDLLKLEDVLRQHPFYFKAAR
IAIEIYLKLHDNPLTDENKEHEADTANMSDKELKKLRNKQRRAQKKAQIEEEKKNAEKEKQQRNQKKKKDDDDEEIGGPKEELIPEKLAK
VETPLEEAIKFLTPLKNLVKNKIETHLFAFEIYFRKEKFLLMLQSVKRAFAIDSSHPWLHECMIRLFNTAVCESKDLSDTVRTVLKQEMN
RLFGATNPKNFNETFLKRNSDSLPHRLSAAKMVYYLDPSSQKRAIELATTLDESLTNRNLQTCMEVLEALYDGSLGDCKEAAEIYRANCH

--------------------------------------------------------------
>In-frame_ENST00000305626_ENST00000398947_TCGA-N8-A4PL-01A_RAB33B_chr4_140375598_+_NAA15_chr4_140255328_length(transcript)=6466nt_BP=638nt
GCTTCCTCCAGAGGGCGGGAACCTTGGACGTGGCGGGGCTGGGTCAGTCAGGGCGCTGGGCCCAGCCTCTCTGCAGGCTGGCCTTCCGCG
CTGCCGTGAAGCCCCCGACAGGTCCCACGCCTGCCTAGGTAGACCGGCGCCAGCCCGAGTGACGCCTGGCGTGTGGCCGCGGGCAGGCGG
CTCCGTGCGGCGGGGCGGGCGGGTGCCACACCTGTGCGGGCAAGGGCGGGGCGGGAAGGTGCGCAGGCGCGCTCGGGGCTGGTGGGCGGT
GGCTCCTGGGAAGTTGCGCAGCCGAACTGGCCGGCTGGGCGCGCGCTCTTGCGGTGGCGTAATCTCTCAGCCTTTCTGTGTCTCCTTTCC
TCCGCCTCAGTTTGGGGCGGGTCGGGGGAATGGCTGAGGAGATGGAGTCGTCGCTCGAGGCAAGCTTTTCGTCCAGCGGGGCAGTGTCAG
GGGCCTCAGGGTTTTTGCCTCCTGCCCGCTCCCGCATCTTCAAGATAATCGTGATCGGCGACTCCAATGTGGGCAAGACATGCCTGACCT
ACCGCTTCTGCGCTGGCCGCTTCCCCGACCGCACCGAGGCCACGATAGGGGTGGATTTCCGAGAACGAGCGGTGGAGATTGATGGGGAGC
GCATCAAGAGGTGTTATGAACATAAACAGTATAGAAATGGATTGAAATTCTGTAAACAAATACTTTCTAATCCCAAATTTGCAGAGCATG
GAGAAACCTTGGCTATGAAAGGATTAACATTGAACTGTTTGGGGAAAAAGGAAGAAGCTTATGAATTGGTTCGTAGAGGTTTGAGAAATG
ACTTGAAGAGTCATGTGTGTTGGCACGTTTATGGCCTTCTTCAGAGGTCAGACAAGAAGTATGATGAAGCCATTAAGTGTTACAGAAATG
CACTAAAATGGGATAAAGACAATCTTCAAATCTTAAGGGACCTTTCCTTACTACAGATTCAAATGCGAGATCTTGAGGGTTACAGGGAAA
CGAGGTATCAGTTACTTCAGCTTCGACCTGCGCAGAGAGCATCATGGATTGGTTATGCTATTGCTTACCATTTATTAGAAGATTATGAAA
TGGCAGCAAAGATTTTAGAAGAATTTAGGAAAACACAACAGACATCCCCTGACAAGGTGGATTATGAATATAGTGAACTACTCTTATATC
AGAATCAAGTTCTTCGGGAAGCAGGTCTCTATAGAGAAGCTTTGGAACATCTTTGTACCTATGAAAAGCAGATTTGTGATAAACTTGCTG
TAGAAGAAACCAAAGGGGAACTTCTGTTGCAACTATGTCGTTTGGAAGATGCTGCAGATGTTTATAGAGGATTGCAAGAGAGAAATCCTG
AAAACTGGGCCTATTACAAAGGCTTGGAAAAAGCACTCAAGCCAGCTAATATGTTAGAACGGCTAAAAATTTATGAGGAAGCCTGGACTA
AATATCCCAGGGGACTGGTGCCAAGAAGGCTGCCGTTAAACTTTTTATCTGGTGAGAAGTTTAAAGAATGTTTGGATAAGTTCCTAAGGA
TGAATTTCAGCAAGGGTTGCCCACCAGTCTTCAATACTTTAAGATCATTATACAAAGACAAAGAAAAGGTGGCAATCATAGAAGAGTTAG
TAGTAGGTTATGAAACCTCTCTAAAAAGCTGCCGGTTATTTAACCCCAATGATGATGGAAAGGAGGAACCACCAACCACATTACTTTGGG
TCCAGTACTACTTGGCACAACATTATGACAAAATTGGTCAGCCATCTATTGCTTTGGAGTACATAAATACTGCTATTGAAAGTACACCTA
CATTAATAGAACTCTTTCTCGTGAAAGCTAAAATCTATAAGCATGCTGGAAATATTAAAGAAGCTGCAAGGTGGATGGATGAGGCCCAGG
CCTTGGACACAGCAGACAGATTTATCAACTCCAAATGTGCAAAATACATGCTAAAAGCCAACCTGATTAAAGAAGCTGAAGAAATGTGCT
CAAAGTTTACAAGGGAAGGAACATCAGCGGTAGAGAATTTGAATGAAATGCAGTGCATGTGGTTCCAAACAGAATGTGCCCAGGCTTATA
AAGCAATGAATAAATTTGGTGAAGCACTTAAGAAATGTCATGAGATTGAGAGACATTTTATAGAAATCACTGATGACCAGTTTGACTTTC
ATACATACTGTATGAGGAAGATTACCCTTAGATCATATGTGGACTTATTAAAACTAGAAGATGTACTTCGACAGCATCCATTTTACTTCA
AGGCAGCAAGAATTGCTATAGAGATCTATTTGAAGCTTCATGACAACCCCCTTACAGATGAGAATAAAGAACACGAAGCTGATACAGCAA
ACATGTCTGACAAAGAGCTAAAGAAGCTACGTAATAAACAAAGAAGAGCTCAAAAGAAAGCCCAGATAGAAGAAGAGAAAAAAAATGCAG
AAAAAGAAAAGCAGCAGAGAAATCAGAAAAAGAAGAAGGATGATGATGATGAGGAGATAGGAGGTCCAAAAGAAGAACTTATTCCAGAGA
AACTGGCCAAGGTTGAAACTCCATTGGAAGAAGCTATTAAATTTTTAACACCGTTGAAGAACTTGGTGAAGAACAAGATAGAGACTCATC
TTTTTGCCTTTGAGATTTACTTTAGGAAAGAAAAGTTTCTTTTGATGCTACAATCAGTAAAGAGGGCATTTGCTATTGATTCTAGTCATC
CCTGGCTTCATGAGTGTATGATTCGTCTCTTTAATACTGTGTGTGAAAGTAAAGATTTATCTGATACAGTTAGAACAGTATTAAAACAAG
AAATGAATCGTCTTTTTGGAGCAACGAATCCAAAGAATTTTAATGAAACTTTTCTGAAAAGGAATTCTGATTCATTGCCACACAGATTAT
CAGCTGCCAAAATGGTATATTACTTAGATCCTTCTAGTCAGAAGCGAGCTATAGAGTTGGCAACAACACTTGATGAATCTCTCACTAACA
GAAACCTCCAGACATGTATGGAGGTATTGGAAGCCTTGTATGATGGTAGCCTAGGAGACTGTAAAGAAGCTGCTGAAATTTATAGAGCAA
ATTGTCATAAGCTTTTCCCTTATGCTTTGGCTTTCATGCCTCCTGGATATGAAGAGGATATGAAGATCACAGTTAATGGAGATAGTTCTG
CAGAAGCTGAAGAACTGGCCAATGAAATTTGAACATCACTAAACAAGCAAATGGAATGACTTTGGACCATATCTAGTATATAATATTTTT
GTCACGCACCTGCTGCATTGCTCTAACTTACACAGAATGAGAGGAGTAAATGTTCTTGCCTTCAAATAGTGTTTTACGTTTTTTATCCTG
CTGAAAAAGTATATATAAAATATCTAACATTACAGGATAGAGGTTCAGTTTCTTAAAAAATTAAAGCTGCTAAAATTGAGTGGTTAAAAA
AGATACCTTATCCTATTCCTCCCCACCCACCCATGTTTTTAAACTAATTTATATAAAATCTGGAGGCTGTTACAGCTAACAAAGCAGGTG
TGTGGCAGAAATATTACTTTAAATTTGTCTTGTGAGATTTTACTATATCTCAGACAGCATAAATGCTGTTTTAGCACTGGATTCTTTCAC
TGAGCACAAAGAGTTGTTGGGGCTTTAGCATCTGACTGATTTTGTTACGGGGTTGATTCTGACCATAGGAAGTATGCAATGTGAATCACT
ATTTACAGAGAAACCTACAACAGATGCTTGATGTTGTAGAAACTGGGACATATAGATACCAAGCAAAATTATAAGAAACCTATAAGGTGT
TCAATACGCTTGTGTTTCCAAAATTCACTGTACATGATCAGTTTGGTGTTCTTGTACCACAGTTTTTAACTGAAGGAACCAGTTGTAACA
GTCTCAATTTTAACTAAAACTTGAAGAACTAAAACAACAATGCAAACCTTTCAGCATTGTTTGGCCAAACTTGTTAAAACTGTAATGCAA
GAACCAAATGCACTGTGATGTGGCACCAACTAATTAGCAAGCATGAATTTTTCACCCAAGAGTGAAAAAAGGAAAATCTACCATGGCTTG
AAGTTAAAGAGCAGAACTCCTGACTACCATTCTATGACTGATCAAAAGACTAATAGTTAAAAACCTCAGCAGGCCTTGTTCACGATATGC
AGAAAAAAAAGTGCTGCAGTTTAGATACCTCTGGAATTTTTCCACAGTGTCACAGGTTTGTAATACTTGAAGCCCTACATTTCTAAGAAT
ATATTTCTTGCTCAGTTGTTTCAGGCAAGCCCAAGACTTTGTAATTTTTAAAGGGCCCAAGATTTTTTTTTTTTTTTTTTTTTTCAAATA
ACAGACCAGCTTCTTTTTCTTGCAGTTACAGATGTAATTTCCTTTTTGTTGTCAAACATAAGGTACCAAATATGATGCAATAAATTGTTT
TGAAAAACAGTTGTGTGAATATTTCAACTAATCTGTGTTGGGCTTCTGTGAAATACACAGGTGGAAACAGAGGTGCAAGCCAGAGGCAAT
GTAATATGCTGTAAGGCTAGTGCAGATGGGAGCTTTTTAGAAGGGGCTAAGTGCTGGTGTCAGGGAAATTCCATAATGAAGTAGAATGCT
GCTCCTGCATTAAGATTTCATTGAGGGCAAGGCTGGTGGCAGGTACTATGAATGTAATTCATAATTTAAAAGGAAAACTAAAAACTATTT
TGATTTGGGAAAATGAGCCTTAATTTGTTAAACCTATACACTGAGAACTAGCCTCAGGCTTAATATTCTCATTGCATTTGCAAGATCTGA
GCAAATAAGATTAAGTAAAACAAATCAATTGTATATATAATTGACCTTTTTGTGGAACATGTAGTTTATAGAAAGTATACTCTAAAGGGA
ATTTGCCGAAGACCTTTTACTGATTGAACAGTTGTGCTACAATCAACTTTTCATAGTACATGACCTGCATTCCACATCTCAGTCTAACAG
TTTAGTAGTGATGTAAAGAGAAGTACAAACCGAACTCCAGTGCTTTGTTATGTTTTATTAACTGGCCCTGTCTCAGGAACATCTTAACAG
ATGGCAAAAAAACAAAAACTTTTTTTCAACTCCTATGAGTGGCAACTGAAGTTCTTATTGTTGGGAAAGAACACTAGTCCTACCTCTGCC
ACTAATGAGGTGTTTGGAGGAGGTACCAGCCATATAATAGGGGGTGTATGTGTGAATTTTGTTTAAACTCTACTGTATATTGAAATGAAA
TTCATTTATTTGTCTTGACAATGTTCAAATGATGTAGATTGTCTTAGAATGAATATTCATAAGTACTCAGAACTCTTAAGATGCAGATGC
CACCCGTGAGGAGCTAAATTCCTAATGTGTATTGTATTCCAACCCAATTTTACTGGAACTATTGAATAAATCTTTTATTTTCTTTCAGGT
TTACTTGATAGTGGATACATTGGTGTCAGAGGACCTTGACTGGGTTCATTTTATGTCCAGACATCACCCCTGAAACACTGTACTGTACTA
TCTTGCTCTGAGTAGTATCAACTGGATCGTCTCATATTTGCCTCATTCATCCTATTAATTTCAAATGATACTGTGGGGGAAAAACAGGGT
TAGAAAAACAAGTGGAAAAAATGGAGTGATGTTGTAATCTAAACAAGTGCCTTATGTTTATTGCTAAGAACTGGTGTTACCAACCCTTTT
GAGAAGAAAGGGTCTCTTGACCTGTATTAACATAGGAAAGTAAAGTTCTTTTTGTTTTTCTTTATATTCAGCTACTCTTGTCATTTCTCG
TTGAAAAACTAAAATCTGACTAGGTTAGTTTACTCAGCTTTAATTAGATAGTTGAGTCATATATTTTCAACATTTTTCTGTATCGTATTT
ATTATGCACAAAAATAAAGTGTGATCTCTAATAGCATGGCTAAAGGTAATGCCAATATTAGTGAATAGCTTTGCTGTGGGCTTTATCAGG
CCCTTGTTTTTCACAGTGTTGTTTGTACTCCATGGTGTATTGCTATTAGAGCTGTGAAATGAAAGCTGTGACTTTATGAAGAGATCAAAA
AAAGTGTGGTCCAGATTCAGGTAGGTTGTGGTAAGTTCAGGGAAGTCTTGTATGATTTCTAAGAATATTTCAGTTACCATGTATAGTATT
TGGGAAAAGCTGTAATGTAAAATATTGGACTTTGTTGCAAGATAGGTATATACTTGTGTCAGATAATTAAAGCCTTAAATTTTGAAATGA
ATCTTTGAGATTTCAAAGAAAGACTGACCTTTCAAATAGAAGGCGGTCTTTCTATTCTAGCTAATGCCCCACTTCTTTAAGTTATAAACA
AAGTTTCATGATACCATTCTGCTATCATCTAAACTTTGCTGAACTCTACTGCCAACCTACATTAAAAACAAAGTCCCACGAAATGGCTGT

>In-frame_ENST00000305626_ENST00000398947_TCGA-N8-A4PL-01A_RAB33B_chr4_140375598_+_NAA15_chr4_140255328_length(amino acids)=936AA_start in transcript=371_stop in transcript=3181
MGRVGGMAEEMESSLEASFSSSGAVSGASGFLPPARSRIFKIIVIGDSNVGKTCLTYRFCAGRFPDRTEATIGVDFRERAVEIDGERIKR
CYEHKQYRNGLKFCKQILSNPKFAEHGETLAMKGLTLNCLGKKEEAYELVRRGLRNDLKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKW
DKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPAQRASWIGYAIAYHLLEDYEMAAKILEEFRKTQQTSPDKVDYEYSELLLYQNQV
LREAGLYREALEHLCTYEKQICDKLAVEETKGELLLQLCRLEDAADVYRGLQERNPENWAYYKGLEKALKPANMLERLKIYEEAWTKYPR
GLVPRRLPLNFLSGEKFKECLDKFLRMNFSKGCPPVFNTLRSLYKDKEKVAIIEELVVGYETSLKSCRLFNPNDDGKEEPPTTLLWVQYY
LAQHYDKIGQPSIALEYINTAIESTPTLIELFLVKAKIYKHAGNIKEAARWMDEAQALDTADRFINSKCAKYMLKANLIKEAEEMCSKFT
REGTSAVENLNEMQCMWFQTECAQAYKAMNKFGEALKKCHEIERHFIEITDDQFDFHTYCMRKITLRSYVDLLKLEDVLRQHPFYFKAAR
IAIEIYLKLHDNPLTDENKEHEADTANMSDKELKKLRNKQRRAQKKAQIEEEKKNAEKEKQQRNQKKKKDDDDEEIGGPKEELIPEKLAK
VETPLEEAIKFLTPLKNLVKNKIETHLFAFEIYFRKEKFLLMLQSVKRAFAIDSSHPWLHECMIRLFNTVCESKDLSDTVRTVLKQEMNR
LFGATNPKNFNETFLKRNSDSLPHRLSAAKMVYYLDPSSQKRAIELATTLDESLTNRNLQTCMEVLEALYDGSLGDCKEAAEIYRANCHK

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Fusion Gene PPI Analysis for RAB33B-NAA15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneNAA15chr4:140375598chr4:140255328ENST00000296543020500_86618.0867.0HYPK


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RAB33B-NAA15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RAB33B-NAA15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRAB33BC3714896SMITH-MCCORT DYSPLASIA 23GENOMICS_ENGLAND;UNIPROT
HgeneRAB33BC1846431SMITH-MCCORT DYSPLASIA1ORPHANET
TgeneNAA15C0020796Profound Mental Retardation1CTD_human
TgeneNAA15C0025363Mental Retardation, Psychosocial1CTD_human
TgeneNAA15C0917816Mental deficiency1CTD_human
TgeneNAA15C3714756Intellectual Disability1CTD_human;GENOMICS_ENGLAND
TgeneNAA15C4540470MENTAL RETARDATION, AUTOSOMAL DOMINANT 501GENOMICS_ENGLAND;UNIPROT