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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:RAB40B-TAF15 (FusionGDB2 ID:70958)

Fusion Gene Summary for RAB40B-TAF15

Fusion gene summary

Fusion gene information	Fusion gene name: RAB40B-TAF15
	Fusion gene ID: 70958
		Hgene	Tgene
	Gene symbol	RAB40B	TAF15
	Gene ID	10966	8148
	Gene name	RAB40B, member RAS oncogene family	TATA-box binding protein associated factor 15
	Synonyms	RAR\|SEC4L	Npl3\|RBP56\|TAF2N\|TAFII68
	Cytomap	17q25.3	17q12
	Type of gene	protein-coding	protein-coding
	Description	ras-related protein Rab-40BGTP-binding protein homologous to Saccharomyces cerevisiae SEC4SOCS box-containing protein RARprotein Rar	TATA-binding protein-associated factor 2NRBP56/CSMF fusionTAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDaTATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56)TATA box-bin
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000571995, ENST00000571880, ENST00000269347, ENST00000538809,	ENST00000588240, ENST00000592237, ENST00000311979,
Fusion gene scores	* DoF score	5 X 3 X 4=60	16 X 11 X 11=1936
	# samples	5	16
	** MAII score	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/1936*10)=-3.59693514238723 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RAB40B [Title/Abstract] AND TAF15 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RAB40B(80656331)-TAF15(34165428), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TAF15	GO:0048255	mRNA stabilization	27378374

Fusion gene breakpoints across RAB40B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TAF15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	COAD	TCGA-D5-6929-01A	RAB40B	chr17	80656331	-	TAF15	chr17	34165428	+
ChimerDB4	COAD	TCGA-D5-6929-01A	RAB40B	chr17	80656331	-	TAF15	chr17	34165428	+

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Fusion Gene ORF analysis for RAB40B-TAF15

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000571995	ENST00000588240	RAB40B	chr17	80656331	-	TAF15	chr17	34165428	+
In-frame	ENST00000571995	ENST00000592237	RAB40B	chr17	80656331	-	TAF15	chr17	34165428	+
In-frame	ENST00000571995	ENST00000311979	RAB40B	chr17	80656331	-	TAF15	chr17	34165428	+
intron-3CDS	ENST00000571880	ENST00000588240	RAB40B	chr17	80656331	-	TAF15	chr17	34165428	+
intron-3CDS	ENST00000571880	ENST00000592237	RAB40B	chr17	80656331	-	TAF15	chr17	34165428	+
intron-3CDS	ENST00000571880	ENST00000311979	RAB40B	chr17	80656331	-	TAF15	chr17	34165428	+
5UTR-3CDS	ENST00000269347	ENST00000588240	RAB40B	chr17	80656331	-	TAF15	chr17	34165428	+
5UTR-3CDS	ENST00000269347	ENST00000592237	RAB40B	chr17	80656331	-	TAF15	chr17	34165428	+
5UTR-3CDS	ENST00000269347	ENST00000311979	RAB40B	chr17	80656331	-	TAF15	chr17	34165428	+
In-frame	ENST00000538809	ENST00000588240	RAB40B	chr17	80656331	-	TAF15	chr17	34165428	+
In-frame	ENST00000538809	ENST00000592237	RAB40B	chr17	80656331	-	TAF15	chr17	34165428	+
In-frame	ENST00000538809	ENST00000311979	RAB40B	chr17	80656331	-	TAF15	chr17	34165428	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000571995	RAB40B	chr17	80656331	-	ENST00000588240	TAF15	chr17	34165428	+	1567	274	238	1269	343
ENST00000571995	RAB40B	chr17	80656331	-	ENST00000592237	TAF15	chr17	34165428	+	1246	274	238	1113	291
ENST00000571995	RAB40B	chr17	80656331	-	ENST00000311979	TAF15	chr17	34165428	+	1559	274	238	1269	343
ENST00000538809	RAB40B	chr17	80656331	-	ENST00000588240	TAF15	chr17	34165428	+	1501	208	172	1203	343
ENST00000538809	RAB40B	chr17	80656331	-	ENST00000592237	TAF15	chr17	34165428	+	1180	208	172	1047	291
ENST00000538809	RAB40B	chr17	80656331	-	ENST00000311979	TAF15	chr17	34165428	+	1493	208	172	1203	343

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000571995	ENST00000588240	RAB40B	chr17	80656331	-	TAF15	chr17	34165428	+	0.003383216	0.9966168
ENST00000571995	ENST00000592237	RAB40B	chr17	80656331	-	TAF15	chr17	34165428	+	0.005098207	0.9949018
ENST00000571995	ENST00000311979	RAB40B	chr17	80656331	-	TAF15	chr17	34165428	+	0.003548317	0.99645174
ENST00000538809	ENST00000588240	RAB40B	chr17	80656331	-	TAF15	chr17	34165428	+	0.003611499	0.99638855
ENST00000538809	ENST00000592237	RAB40B	chr17	80656331	-	TAF15	chr17	34165428	+	0.00551729	0.99448276
ENST00000538809	ENST00000311979	RAB40B	chr17	80656331	-	TAF15	chr17	34165428	+	0.003808521	0.9961915

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Fusion Genomic Features for RAB40B-TAF15

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
RAB40B	chr17	80656330	-	TAF15	chr17	34165427	+	1.11E-13	1
RAB40B	chr17	80656330	-	TAF15	chr17	34165427	+	1.11E-13	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RAB40B-TAF15

Go to
FGviewer for the breakpoints of chr17:80656331-chr17:34165428
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RAB40B

chr17:80656331

chr17:34165428

ENST00000571995

21_28

47.333333333333336

279.0

Nucleotide binding

GTP

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

320_590

258.0

590.0

Compositional bias

Note=Arg/Gly-rich

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

320_590

261.0

593.0

Compositional bias

Note=Arg/Gly-rich

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

407_575

258.0

590.0

Region

Note=21 X approximate tandem repeats of D-R-[S%2CG](0%2C3)-G-G-Y-G-G

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

407_575

261.0

593.0

Region

Note=21 X approximate tandem repeats of D-R-[S%2CG](0%2C3)-G-G-Y-G-G

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

407_413

258.0

590.0

Repeat

Note=1

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

414_420

258.0

590.0

Repeat

Note=2

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

421_429

258.0

590.0

Repeat

Note=3

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

430_439

258.0

590.0

Repeat

Note=4

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

440_448

258.0

590.0

Repeat

Note=5

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

449_457

258.0

590.0

Repeat

Note=6

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

458_465

258.0

590.0

Repeat

Note=7

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

466_473

258.0

590.0

Repeat

Note=8

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

474_481

258.0

590.0

Repeat

Note=9

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

482_488

258.0

590.0

Repeat

Note=10

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

489_496

258.0

590.0

Repeat

Note=11

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

497_503

258.0

590.0

Repeat

Note=12

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

504_510

258.0

590.0

Repeat

Note=13

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

511_517

258.0

590.0

Repeat

Note=14

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

518_524

258.0

590.0

Repeat

Note=15

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

525_533

258.0

590.0

Repeat

Note=16

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

534_543

258.0

590.0

Repeat

Note=17

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

544_551

258.0

590.0

Repeat

Note=18

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

552_560

258.0

590.0

Repeat

Note=19

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

561_568

258.0

590.0

Repeat

Note=20

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

569_575

258.0

590.0

Repeat

Note=21

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

407_413

261.0

593.0

Repeat

Note=1

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

414_420

261.0

593.0

Repeat

Note=2

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

421_429

261.0

593.0

Repeat

Note=3

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

430_439

261.0

593.0

Repeat

Note=4

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

440_448

261.0

593.0

Repeat

Note=5

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

449_457

261.0

593.0

Repeat

Note=6

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

458_465

261.0

593.0

Repeat

Note=7

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

466_473

261.0

593.0

Repeat

Note=8

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

474_481

261.0

593.0

Repeat

Note=9

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

482_488

261.0

593.0

Repeat

Note=10

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

489_496

261.0

593.0

Repeat

Note=11

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

497_503

261.0

593.0

Repeat

Note=12

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

504_510

261.0

593.0

Repeat

Note=13

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

511_517

261.0

593.0

Repeat

Note=14

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

518_524

261.0

593.0

Repeat

Note=15

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

525_533

261.0

593.0

Repeat

Note=16

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

534_543

261.0

593.0

Repeat

Note=17

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

544_551

261.0

593.0

Repeat

Note=18

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

552_560

261.0

593.0

Repeat

Note=19

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

561_568

261.0

593.0

Repeat

Note=20

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

569_575

261.0

593.0

Repeat

Note=21

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

354_385

258.0

590.0

Zinc finger

RanBP2-type

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

354_385

261.0

593.0

Zinc finger

RanBP2-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RAB40B

chr17:80656331

chr17:34165428

ENST00000571995

175_228

47.333333333333336

279.0

Domain

SOCS box

Hgene

RAB40B

chr17:80656331

chr17:34165428

ENST00000571995

126_129

47.333333333333336

279.0

Nucleotide binding

GTP

Hgene

RAB40B

chr17:80656331

chr17:34165428

ENST00000571995

69_73

47.333333333333336

279.0

Nucleotide binding

GTP

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

1_208

258.0

590.0

Compositional bias

Note=Gln/Gly/Ser/Tyr-rich

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

1_208

261.0

593.0

Compositional bias

Note=Gln/Gly/Ser/Tyr-rich

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000311979

234_320

258.0

590.0

Domain

RRM

Tgene

TAF15

chr17:80656331

chr17:34165428

ENST00000588240

234_320

261.0

593.0

Domain

RRM

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Fusion Gene Sequence for RAB40B-TAF15

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000571995_ENST00000588240_TCGA-D5-6929-01A_RAB40B_chr17_80656331_-_TAF15_chr17_34165428_length(transcript)=1567nt_BP=274nt
AGCGCTGGGCGGCGGGGCGGGGCCGGAGGCGAGCAAGGACTCGGGGCCCGCGCGGCGCCTCTCGGGGCCGGGCCGCCGCCTCTGCGCTCA
GCCCCGCAGGCCGGGCATGGGTGGGGGCGCCGGGCCGTCACGATGAGCGCCCTGGGCAGCCCGGTCCGGGCCTACGACTTTCTGCTCAAG
TTCCTGCTGGTGGGCGACAGCGACGTGGGCAAGGGCGAGATCCTGGCGAGCCTGCAGGATGGCGCGGCCGAGTCCCCGTACGGCCACCCG
GCGGACAAATAAGAAGACCGGAAAACCAATGATAAATCTTTATACAGACAAGGACACAGGAAAGCCAAAGGGGGAGGCAACAGTGTCATT
TGATGACCCTCCTTCAGCTAAGGCAGCCATTGACTGGTTTGATGGAAAAGAATTCCATGGCAACATCATTAAAGTGTCCTTTGCCACTAG
AAGACCTGAATTCATGAGAGGAGGTGGAAGTGGAGGTGGGCGGCGAGGCCGTGGAGGATATAGAGGTCGTGGAGGCTTTCAAGGGAGAGG
TGGAGACCCCAAAAGTGGGGATTGGGTTTGCCCTAATCCGTCATGCGGAAATATGAACTTTGCTCGAAGGAATTCCTGCAATCAGTGCAA
TGAGCCTAGACCAGAGGACTCTCGTCCCTCAGGAGGAGATTTCCGGGGGAGAGGCTACGGTGGAGAGAGGGGCTACAGAGGTCGTGGGGG
CAGAGGTGGAGACCGAGGCGGCTATGGTGGAGACAGAAGTGGGGGTGGCTATGGTGGAGACAGAAGCAGCGGTGGTGGCTACAGCGGAGA
TAGAAGTGGGGGCGGCTATGGTGGAGACAGAAGTGGGGGTGGCTATGGTGGGGACAGAGGCGGCGGCTATGGTGGGGACAGAGGAGGCGG
CTATGGAGGAGACCGAGGAGGTGGCTATGGAGGAGATCGAGGTGGCTATGGAGGAGACCGAGGTGGAGGCTATGGTGGAGACCGAGGAGG
CTATGGAGGAGATCGAGGAGGTTACGGAGGAGATCGAGGAGGTTATGGAGGAGATCGAGGAGGCTATGGAGGAGACAGAAGCCGGGGGGG
CTATGGAGGAGACCGTGGTGGTGGCAGTGGCTACGGTGGAGACCGAAGTGGAGGCTATGGAGGAGACAGGAGTGGTGGCGGCTATGGAGG
AGACCGAGGTGGGGGCTACGGAGGAGACCGAGGTGGCTATGGAGGCAAAATGGGAGGAAGAAACGACTACAGAAATGATCAGCGCAACCG
ACCATACTGATGACTGTTTTGAATGTTCCTTTGTCTCTGACATGATCCATAGTGAAATTGCCAGAGTTTTGCCTGCTGCTTTCCTCGTGG
CCTCTTCTTGGGTAGTGAAATTAAGTGACATTTGGATTTTTATTTGGGTGGGAGGGCTGGGACAGTTTTTCTTCTAGAAATGTCTGTTGA
GATTTCCCCCTTTAGTTTCCAACCTTCTCCCCAACCCTTGGAGCTAAATGCGTTGTAAAATATTGCCAAAATGAAAAGTGTTTTGTAATA

>In-frame_ENST00000571995_ENST00000588240_TCGA-D5-6929-01A_RAB40B_chr17_80656331_-_TAF15_chr17_34165428_length(amino acids)=343AA_start in transcript=238_stop in transcript=1269
MARPSPRTATRRTNKKTGKPMINLYTDKDTGKPKGEATVSFDDPPSAKAAIDWFDGKEFHGNIIKVSFATRRPEFMRGGGSGGGRRGRGG
YRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGGDRSGGGYGG
DRSSGGGYSGDRSGGGYGGDRSGGGYGGDRGGGYGGDRGGGYGGDRGGGYGGDRGGYGGDRGGGYGGDRGGYGGDRGGYGGDRGGYGGDR

--------------------------------------------------------------
>In-frame_ENST00000571995_ENST00000592237_TCGA-D5-6929-01A_RAB40B_chr17_80656331_-_TAF15_chr17_34165428_length(transcript)=1246nt_BP=274nt
AGCGCTGGGCGGCGGGGCGGGGCCGGAGGCGAGCAAGGACTCGGGGCCCGCGCGGCGCCTCTCGGGGCCGGGCCGCCGCCTCTGCGCTCA
GCCCCGCAGGCCGGGCATGGGTGGGGGCGCCGGGCCGTCACGATGAGCGCCCTGGGCAGCCCGGTCCGGGCCTACGACTTTCTGCTCAAG
TTCCTGCTGGTGGGCGACAGCGACGTGGGCAAGGGCGAGATCCTGGCGAGCCTGCAGGATGGCGCGGCCGAGTCCCCGTACGGCCACCCG
GCGGACAAATAAGAAGACCGGAAAACCAATGATAAATCTTTATACAGACAAGGACACAGGAAAGCCAAAGGGGGAGGCAACAGTGTCATT
TGATGACCCTCCTTCAGCTAAGGCAGCCATTGACTGGTTTGATGGAAAAGAATTCCATGGCAACATCATTAAAGTGTCCTTTGCCACTAG
AAGACCTGAATTCATGAGAGGAGGTGGAAGTGGAGGTGGGCGGCGAGGCCGTGGAGGATATAGAGGTCGTGGAGGCTTTCAAGGGAGAGG
TGGAGACCCCAAAAGTGGGGATTGGGTTTGCCCTAATCCGTCATGCGGAAATATGAACTTTGCTCGAAGGAATTCCTGCAATCAGTGCAA
TGAGCCTAGACCAGAGGACTCTCGTCCCTCAGGAGGAGATTTCCGGGGGAGAGGCTACGGTGGAGAGAGGGGCTACAGAGGTCGTGGGGG
CAGAGGTGGAGACCGAGGCGGCTATGGTGGAGACAGAACCGGGGGGGCTATGGAGGAGACCGTGGTGGTGGCAGTGGCTACGGTGGAGAC
CGAAGTGGAGGCTATGGAGGAGACAGGAGTGGTGGCGGCTATGGAGGAGACCGAGGTGGGGGCTACGGAGGAGACCGAGGTGGCTATGGA
GGCAAAATGGGAGGAAGAAACGACTACAGAAATGATCAGCGCAACCGACCATACTGATGACTGTTTTGAATGTTCCTTTGTCTCTGACAT
GATCCATAGTGAAATTGCCAGAGTTTTGCCTGCTGCTTTCCTCGTGGCCTCTTCTTGGGTAGTGAAATTAAGTGACATTTGGATTTTTAT
TTGGGTGGGAGGGCTGGGACAGTTTTTCTTCTAGAAATGTCTGTTGAGATTTCCCCCTTTAGTTTCCAACCTTCTCCCCAACCCTTGGAG

>In-frame_ENST00000571995_ENST00000592237_TCGA-D5-6929-01A_RAB40B_chr17_80656331_-_TAF15_chr17_34165428_length(amino acids)=291AA_start in transcript=238_stop in transcript=1113
MARPSPRTATRRTNKKTGKPMINLYTDKDTGKPKGEATVSFDDPPSAKAAIDWFDGKEFHGNIIKVSFATRRPEFMRGGGSGGGRRGRGG
YRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGGDRTGGAMEE
TVVVAVATVETEVEAMEETGVVAAMEETEVGATEETEVAMEAKWEEETTTEMISATDHTDDCFECSFVSDMIHSEIARVLPAAFLVASSW

--------------------------------------------------------------
>In-frame_ENST00000571995_ENST00000311979_TCGA-D5-6929-01A_RAB40B_chr17_80656331_-_TAF15_chr17_34165428_length(transcript)=1559nt_BP=274nt
AGCGCTGGGCGGCGGGGCGGGGCCGGAGGCGAGCAAGGACTCGGGGCCCGCGCGGCGCCTCTCGGGGCCGGGCCGCCGCCTCTGCGCTCA
GCCCCGCAGGCCGGGCATGGGTGGGGGCGCCGGGCCGTCACGATGAGCGCCCTGGGCAGCCCGGTCCGGGCCTACGACTTTCTGCTCAAG
TTCCTGCTGGTGGGCGACAGCGACGTGGGCAAGGGCGAGATCCTGGCGAGCCTGCAGGATGGCGCGGCCGAGTCCCCGTACGGCCACCCG
GCGGACAAATAAGAAGACCGGAAAACCAATGATAAATCTTTATACAGACAAGGACACAGGAAAGCCAAAGGGGGAGGCAACAGTGTCATT
TGATGACCCTCCTTCAGCTAAGGCAGCCATTGACTGGTTTGATGGAAAAGAATTCCATGGCAACATCATTAAAGTGTCCTTTGCCACTAG
AAGACCTGAATTCATGAGAGGAGGTGGAAGTGGAGGTGGGCGGCGAGGCCGTGGAGGATATAGAGGTCGTGGAGGCTTTCAAGGGAGAGG
TGGAGACCCCAAAAGTGGGGATTGGGTTTGCCCTAATCCGTCATGCGGAAATATGAACTTTGCTCGAAGGAATTCCTGCAATCAGTGCAA
TGAGCCTAGACCAGAGGACTCTCGTCCCTCAGGAGGAGATTTCCGGGGGAGAGGCTACGGTGGAGAGAGGGGCTACAGAGGTCGTGGGGG
CAGAGGTGGAGACCGAGGCGGCTATGGTGGAGACAGAAGTGGGGGTGGCTATGGTGGAGACAGAAGCAGCGGTGGTGGCTACAGCGGAGA
TAGAAGTGGGGGCGGCTATGGTGGAGACAGAAGTGGGGGTGGCTATGGTGGGGACAGAGGCGGCGGCTATGGTGGGGACAGAGGAGGCGG
CTATGGAGGAGACCGAGGAGGTGGCTATGGAGGAGATCGAGGTGGCTATGGAGGAGACCGAGGTGGAGGCTATGGTGGAGACCGAGGAGG
CTATGGAGGAGATCGAGGAGGTTACGGAGGAGATCGAGGAGGTTATGGAGGAGATCGAGGAGGCTATGGAGGAGACAGAAGCCGGGGGGG
CTATGGAGGAGACCGTGGTGGTGGCAGTGGCTACGGTGGAGACCGAAGTGGAGGCTATGGAGGAGACAGGAGTGGTGGCGGCTATGGAGG
AGACCGAGGTGGGGGCTACGGAGGAGACCGAGGTGGCTATGGAGGCAAAATGGGAGGAAGAAACGACTACAGAAATGATCAGCGCAACCG
ACCATACTGATGACTGTTTTGAATGTTCCTTTGTCTCTGACATGATCCATAGTGAAATTGCCAGAGTTTTGCCTGCTGCTTTCCTCGTGG
CCTCTTCTTGGGTAGTGAAATTAAGTGACATTTGGATTTTTATTTGGGTGGGAGGGCTGGGACAGTTTTTCTTCTAGAAATGTCTGTTGA
GATTTCCCCCTTTAGTTTCCAACCTTCTCCCCAACCCTTGGAGCTAAATGCGTTGTAAAATATTGCCAAAATGAAAAGTGTTTTGTAATA

>In-frame_ENST00000571995_ENST00000311979_TCGA-D5-6929-01A_RAB40B_chr17_80656331_-_TAF15_chr17_34165428_length(amino acids)=343AA_start in transcript=238_stop in transcript=1269
MARPSPRTATRRTNKKTGKPMINLYTDKDTGKPKGEATVSFDDPPSAKAAIDWFDGKEFHGNIIKVSFATRRPEFMRGGGSGGGRRGRGG
YRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGGDRSGGGYGG
DRSSGGGYSGDRSGGGYGGDRSGGGYGGDRGGGYGGDRGGGYGGDRGGGYGGDRGGYGGDRGGGYGGDRGGYGGDRGGYGGDRGGYGGDR

--------------------------------------------------------------
>In-frame_ENST00000538809_ENST00000588240_TCGA-D5-6929-01A_RAB40B_chr17_80656331_-_TAF15_chr17_34165428_length(transcript)=1501nt_BP=208nt
GCCGGGCCGCCGCCTCTGCGCTCAGCCCCGCAGGCCGGGCATGGGTGGGGGCGCCGGGCCGTCACGATGAGCGCCCTGGGCAGCCCGGTC
CGGGCCTACGACTTTCTGCTCAAGTTCCTGCTGGTGGGCGACAGCGACGTGGGCAAGGGCGAGATCCTGGCGAGCCTGCAGGATGGCGCG
GCCGAGTCCCCGTACGGCCACCCGGCGGACAAATAAGAAGACCGGAAAACCAATGATAAATCTTTATACAGACAAGGACACAGGAAAGCC
AAAGGGGGAGGCAACAGTGTCATTTGATGACCCTCCTTCAGCTAAGGCAGCCATTGACTGGTTTGATGGAAAAGAATTCCATGGCAACAT
CATTAAAGTGTCCTTTGCCACTAGAAGACCTGAATTCATGAGAGGAGGTGGAAGTGGAGGTGGGCGGCGAGGCCGTGGAGGATATAGAGG
TCGTGGAGGCTTTCAAGGGAGAGGTGGAGACCCCAAAAGTGGGGATTGGGTTTGCCCTAATCCGTCATGCGGAAATATGAACTTTGCTCG
AAGGAATTCCTGCAATCAGTGCAATGAGCCTAGACCAGAGGACTCTCGTCCCTCAGGAGGAGATTTCCGGGGGAGAGGCTACGGTGGAGA
GAGGGGCTACAGAGGTCGTGGGGGCAGAGGTGGAGACCGAGGCGGCTATGGTGGAGACAGAAGTGGGGGTGGCTATGGTGGAGACAGAAG
CAGCGGTGGTGGCTACAGCGGAGATAGAAGTGGGGGCGGCTATGGTGGAGACAGAAGTGGGGGTGGCTATGGTGGGGACAGAGGCGGCGG
CTATGGTGGGGACAGAGGAGGCGGCTATGGAGGAGACCGAGGAGGTGGCTATGGAGGAGATCGAGGTGGCTATGGAGGAGACCGAGGTGG
AGGCTATGGTGGAGACCGAGGAGGCTATGGAGGAGATCGAGGAGGTTACGGAGGAGATCGAGGAGGTTATGGAGGAGATCGAGGAGGCTA
TGGAGGAGACAGAAGCCGGGGGGGCTATGGAGGAGACCGTGGTGGTGGCAGTGGCTACGGTGGAGACCGAAGTGGAGGCTATGGAGGAGA
CAGGAGTGGTGGCGGCTATGGAGGAGACCGAGGTGGGGGCTACGGAGGAGACCGAGGTGGCTATGGAGGCAAAATGGGAGGAAGAAACGA
CTACAGAAATGATCAGCGCAACCGACCATACTGATGACTGTTTTGAATGTTCCTTTGTCTCTGACATGATCCATAGTGAAATTGCCAGAG
TTTTGCCTGCTGCTTTCCTCGTGGCCTCTTCTTGGGTAGTGAAATTAAGTGACATTTGGATTTTTATTTGGGTGGGAGGGCTGGGACAGT
TTTTCTTCTAGAAATGTCTGTTGAGATTTCCCCCTTTAGTTTCCAACCTTCTCCCCAACCCTTGGAGCTAAATGCGTTGTAAAATATTGC

>In-frame_ENST00000538809_ENST00000588240_TCGA-D5-6929-01A_RAB40B_chr17_80656331_-_TAF15_chr17_34165428_length(amino acids)=343AA_start in transcript=172_stop in transcript=1203
MARPSPRTATRRTNKKTGKPMINLYTDKDTGKPKGEATVSFDDPPSAKAAIDWFDGKEFHGNIIKVSFATRRPEFMRGGGSGGGRRGRGG
YRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGGDRSGGGYGG
DRSSGGGYSGDRSGGGYGGDRSGGGYGGDRGGGYGGDRGGGYGGDRGGGYGGDRGGYGGDRGGGYGGDRGGYGGDRGGYGGDRGGYGGDR

--------------------------------------------------------------
>In-frame_ENST00000538809_ENST00000592237_TCGA-D5-6929-01A_RAB40B_chr17_80656331_-_TAF15_chr17_34165428_length(transcript)=1180nt_BP=208nt
GCCGGGCCGCCGCCTCTGCGCTCAGCCCCGCAGGCCGGGCATGGGTGGGGGCGCCGGGCCGTCACGATGAGCGCCCTGGGCAGCCCGGTC
CGGGCCTACGACTTTCTGCTCAAGTTCCTGCTGGTGGGCGACAGCGACGTGGGCAAGGGCGAGATCCTGGCGAGCCTGCAGGATGGCGCG
GCCGAGTCCCCGTACGGCCACCCGGCGGACAAATAAGAAGACCGGAAAACCAATGATAAATCTTTATACAGACAAGGACACAGGAAAGCC
AAAGGGGGAGGCAACAGTGTCATTTGATGACCCTCCTTCAGCTAAGGCAGCCATTGACTGGTTTGATGGAAAAGAATTCCATGGCAACAT
CATTAAAGTGTCCTTTGCCACTAGAAGACCTGAATTCATGAGAGGAGGTGGAAGTGGAGGTGGGCGGCGAGGCCGTGGAGGATATAGAGG
TCGTGGAGGCTTTCAAGGGAGAGGTGGAGACCCCAAAAGTGGGGATTGGGTTTGCCCTAATCCGTCATGCGGAAATATGAACTTTGCTCG
AAGGAATTCCTGCAATCAGTGCAATGAGCCTAGACCAGAGGACTCTCGTCCCTCAGGAGGAGATTTCCGGGGGAGAGGCTACGGTGGAGA
GAGGGGCTACAGAGGTCGTGGGGGCAGAGGTGGAGACCGAGGCGGCTATGGTGGAGACAGAACCGGGGGGGCTATGGAGGAGACCGTGGT
GGTGGCAGTGGCTACGGTGGAGACCGAAGTGGAGGCTATGGAGGAGACAGGAGTGGTGGCGGCTATGGAGGAGACCGAGGTGGGGGCTAC
GGAGGAGACCGAGGTGGCTATGGAGGCAAAATGGGAGGAAGAAACGACTACAGAAATGATCAGCGCAACCGACCATACTGATGACTGTTT
TGAATGTTCCTTTGTCTCTGACATGATCCATAGTGAAATTGCCAGAGTTTTGCCTGCTGCTTTCCTCGTGGCCTCTTCTTGGGTAGTGAA
ATTAAGTGACATTTGGATTTTTATTTGGGTGGGAGGGCTGGGACAGTTTTTCTTCTAGAAATGTCTGTTGAGATTTCCCCCTTTAGTTTC
CAACCTTCTCCCCAACCCTTGGAGCTAAATGCGTTGTAAAATATTGCCAAAATGAAAAGTGTTTTGTAATACTGCAATAAAGGCTGCTTG

>In-frame_ENST00000538809_ENST00000592237_TCGA-D5-6929-01A_RAB40B_chr17_80656331_-_TAF15_chr17_34165428_length(amino acids)=291AA_start in transcript=172_stop in transcript=1047
MARPSPRTATRRTNKKTGKPMINLYTDKDTGKPKGEATVSFDDPPSAKAAIDWFDGKEFHGNIIKVSFATRRPEFMRGGGSGGGRRGRGG
YRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGGDRTGGAMEE
TVVVAVATVETEVEAMEETGVVAAMEETEVGATEETEVAMEAKWEEETTTEMISATDHTDDCFECSFVSDMIHSEIARVLPAAFLVASSW

--------------------------------------------------------------
>In-frame_ENST00000538809_ENST00000311979_TCGA-D5-6929-01A_RAB40B_chr17_80656331_-_TAF15_chr17_34165428_length(transcript)=1493nt_BP=208nt
GCCGGGCCGCCGCCTCTGCGCTCAGCCCCGCAGGCCGGGCATGGGTGGGGGCGCCGGGCCGTCACGATGAGCGCCCTGGGCAGCCCGGTC
CGGGCCTACGACTTTCTGCTCAAGTTCCTGCTGGTGGGCGACAGCGACGTGGGCAAGGGCGAGATCCTGGCGAGCCTGCAGGATGGCGCG
GCCGAGTCCCCGTACGGCCACCCGGCGGACAAATAAGAAGACCGGAAAACCAATGATAAATCTTTATACAGACAAGGACACAGGAAAGCC
AAAGGGGGAGGCAACAGTGTCATTTGATGACCCTCCTTCAGCTAAGGCAGCCATTGACTGGTTTGATGGAAAAGAATTCCATGGCAACAT
CATTAAAGTGTCCTTTGCCACTAGAAGACCTGAATTCATGAGAGGAGGTGGAAGTGGAGGTGGGCGGCGAGGCCGTGGAGGATATAGAGG
TCGTGGAGGCTTTCAAGGGAGAGGTGGAGACCCCAAAAGTGGGGATTGGGTTTGCCCTAATCCGTCATGCGGAAATATGAACTTTGCTCG
AAGGAATTCCTGCAATCAGTGCAATGAGCCTAGACCAGAGGACTCTCGTCCCTCAGGAGGAGATTTCCGGGGGAGAGGCTACGGTGGAGA
GAGGGGCTACAGAGGTCGTGGGGGCAGAGGTGGAGACCGAGGCGGCTATGGTGGAGACAGAAGTGGGGGTGGCTATGGTGGAGACAGAAG
CAGCGGTGGTGGCTACAGCGGAGATAGAAGTGGGGGCGGCTATGGTGGAGACAGAAGTGGGGGTGGCTATGGTGGGGACAGAGGCGGCGG
CTATGGTGGGGACAGAGGAGGCGGCTATGGAGGAGACCGAGGAGGTGGCTATGGAGGAGATCGAGGTGGCTATGGAGGAGACCGAGGTGG
AGGCTATGGTGGAGACCGAGGAGGCTATGGAGGAGATCGAGGAGGTTACGGAGGAGATCGAGGAGGTTATGGAGGAGATCGAGGAGGCTA
TGGAGGAGACAGAAGCCGGGGGGGCTATGGAGGAGACCGTGGTGGTGGCAGTGGCTACGGTGGAGACCGAAGTGGAGGCTATGGAGGAGA
CAGGAGTGGTGGCGGCTATGGAGGAGACCGAGGTGGGGGCTACGGAGGAGACCGAGGTGGCTATGGAGGCAAAATGGGAGGAAGAAACGA
CTACAGAAATGATCAGCGCAACCGACCATACTGATGACTGTTTTGAATGTTCCTTTGTCTCTGACATGATCCATAGTGAAATTGCCAGAG
TTTTGCCTGCTGCTTTCCTCGTGGCCTCTTCTTGGGTAGTGAAATTAAGTGACATTTGGATTTTTATTTGGGTGGGAGGGCTGGGACAGT
TTTTCTTCTAGAAATGTCTGTTGAGATTTCCCCCTTTAGTTTCCAACCTTCTCCCCAACCCTTGGAGCTAAATGCGTTGTAAAATATTGC

>In-frame_ENST00000538809_ENST00000311979_TCGA-D5-6929-01A_RAB40B_chr17_80656331_-_TAF15_chr17_34165428_length(amino acids)=343AA_start in transcript=172_stop in transcript=1203
MARPSPRTATRRTNKKTGKPMINLYTDKDTGKPKGEATVSFDDPPSAKAAIDWFDGKEFHGNIIKVSFATRRPEFMRGGGSGGGRRGRGG
YRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGGDRSGGGYGG
DRSSGGGYSGDRSGGGYGGDRSGGGYGGDRGGGYGGDRGGGYGGDRGGGYGGDRGGYGGDRGGGYGGDRGGYGGDRGGYGGDRGGYGGDR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RAB40B-TAF15

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for RAB40B-TAF15

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for RAB40B-TAF15

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	RAB40B	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Tgene	TAF15	C0002736	Amyotrophic Lateral Sclerosis	2	GENOMICS_ENGLAND;ORPHANET
Tgene	TAF15	C0024623	Malignant neoplasm of stomach	1	CTD_human
Tgene	TAF15	C0029463	Osteosarcoma	1	CTD_human
Tgene	TAF15	C0038356	Stomach Neoplasms	1	CTD_human
Tgene	TAF15	C0235874	Disease Exacerbation	1	CTD_human
Tgene	TAF15	C1275278	Extraskeletal Myxoid Chondrosarcoma	1	CTD_human;ORPHANET
Tgene	TAF15	C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human