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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RAB6A-MRPL48 (FusionGDB2 ID:71010)

Fusion Gene Summary for RAB6A-MRPL48

check button Fusion gene summary
Fusion gene informationFusion gene name: RAB6A-MRPL48
Fusion gene ID: 71010
HgeneTgene
Gene symbol

RAB6A

MRPL48

Gene ID

5870

51642

Gene nameRAB6A, member RAS oncogene familymitochondrial ribosomal protein L48
SynonymsRAB6CGI-118|HSPC290|L48MT|MRP-L48
Cytomap

11q13.4

11q13.4

Type of geneprotein-codingprotein-coding
Descriptionras-related protein Rab-6ARAB6, member RAS oncogene familyRab GTPase39S ribosomal protein L48, mitochondrialmitochondrial large ribosomal subunit protein mL48
Modification date2020031320200313
UniProtAcc.

Q96GC5

Ensembl transtripts involved in fusion geneENST00000310653, ENST00000336083, 
ENST00000536566, ENST00000541588, 
ENST00000310614, ENST00000535529, 
ENST00000411840, ENST00000398483, 
ENST00000542303, ENST00000314282, 
Fusion gene scores* DoF score14 X 11 X 8=123213 X 10 X 8=1040
# samples 1716
** MAII scorelog2(17/1232*10)=-2.8573956045572
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1040*10)=-2.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAB6A [Title/Abstract] AND MRPL48 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRAB6A(73471611)-MRPL48(73516072), # samples:2
MRPL48(73505394)-RAB6A(73450106), # samples:1
Anticipated loss of major functional domain due to fusion event.RAB6A-MRPL48 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAB6A

GO:0018125

peptidyl-cysteine methylation

11121396

HgeneRAB6A

GO:0034067

protein localization to Golgi apparatus

12447383|18243103


check buttonFusion gene breakpoints across RAB6A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MRPL48 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0AJRAB6Achr11

73471610

-MRPL48chr11

73516071

+
ChimerDB4BRCATCGA-AN-A0AJ-01ARAB6Achr11

73471611

-MRPL48chr11

73516072

+
ChimerDB4BRCATCGA-AN-A0AJ-01ARAB6Achr11

73471611

-MRPL48chr11

73536753

+
ChimerDB4BRCATCGA-AN-A0AJ-01ARAB6Achr11

73471611

-MRPL48chr11

73516072

+
ChiTaRS5.0N/ABF245064RAB6Achr11

73420989

-MRPL48chr11

73505051

-
ChiTaRS5.0N/ABF245550RAB6Achr11

73421004

-MRPL48chr11

73505051

-


Top

Fusion Gene ORF analysis for RAB6A-MRPL48

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000310653ENST00000310614RAB6Achr11

73471610

-MRPL48chr11

73516071

+
5CDS-5UTRENST00000310653ENST00000535529RAB6Achr11

73471610

-MRPL48chr11

73516071

+
5CDS-5UTRENST00000310653ENST00000411840RAB6Achr11

73471610

-MRPL48chr11

73516071

+
5CDS-5UTRENST00000310653ENST00000398483RAB6Achr11

73471610

-MRPL48chr11

73516071

+
5CDS-5UTRENST00000310653ENST00000542303RAB6Achr11

73471610

-MRPL48chr11

73516071

+
5CDS-intronENST00000310653ENST00000314282RAB6Achr11

73471610

-MRPL48chr11

73516071

+
In-frameENST00000336083ENST00000310614RAB6Achr11

73471610

-MRPL48chr11

73516071

+
5CDS-5UTRENST00000336083ENST00000535529RAB6Achr11

73471610

-MRPL48chr11

73516071

+
5CDS-5UTRENST00000336083ENST00000411840RAB6Achr11

73471610

-MRPL48chr11

73516071

+
5CDS-5UTRENST00000336083ENST00000398483RAB6Achr11

73471610

-MRPL48chr11

73516071

+
5CDS-5UTRENST00000336083ENST00000542303RAB6Achr11

73471610

-MRPL48chr11

73516071

+
5CDS-intronENST00000336083ENST00000314282RAB6Achr11

73471610

-MRPL48chr11

73516071

+
intron-3CDSENST00000536566ENST00000310614RAB6Achr11

73471610

-MRPL48chr11

73516071

+
intron-5UTRENST00000536566ENST00000535529RAB6Achr11

73471610

-MRPL48chr11

73516071

+
intron-5UTRENST00000536566ENST00000411840RAB6Achr11

73471610

-MRPL48chr11

73516071

+
intron-5UTRENST00000536566ENST00000398483RAB6Achr11

73471610

-MRPL48chr11

73516071

+
intron-5UTRENST00000536566ENST00000542303RAB6Achr11

73471610

-MRPL48chr11

73516071

+
intron-intronENST00000536566ENST00000314282RAB6Achr11

73471610

-MRPL48chr11

73516071

+
In-frameENST00000541588ENST00000310614RAB6Achr11

73471610

-MRPL48chr11

73516071

+
5CDS-5UTRENST00000541588ENST00000535529RAB6Achr11

73471610

-MRPL48chr11

73516071

+
5CDS-5UTRENST00000541588ENST00000411840RAB6Achr11

73471610

-MRPL48chr11

73516071

+
5CDS-5UTRENST00000541588ENST00000398483RAB6Achr11

73471610

-MRPL48chr11

73516071

+
5CDS-5UTRENST00000541588ENST00000542303RAB6Achr11

73471610

-MRPL48chr11

73516071

+
5CDS-intronENST00000541588ENST00000314282RAB6Achr11

73471610

-MRPL48chr11

73516071

+
In-frameENST00000310653ENST00000310614RAB6Achr11

73471611

-MRPL48chr11

73516072

+
5CDS-5UTRENST00000310653ENST00000535529RAB6Achr11

73471611

-MRPL48chr11

73516072

+
5CDS-5UTRENST00000310653ENST00000411840RAB6Achr11

73471611

-MRPL48chr11

73516072

+
5CDS-5UTRENST00000310653ENST00000398483RAB6Achr11

73471611

-MRPL48chr11

73516072

+
5CDS-5UTRENST00000310653ENST00000542303RAB6Achr11

73471611

-MRPL48chr11

73516072

+
5CDS-intronENST00000310653ENST00000314282RAB6Achr11

73471611

-MRPL48chr11

73516072

+
In-frameENST00000336083ENST00000310614RAB6Achr11

73471611

-MRPL48chr11

73516072

+
5CDS-5UTRENST00000336083ENST00000535529RAB6Achr11

73471611

-MRPL48chr11

73516072

+
5CDS-5UTRENST00000336083ENST00000411840RAB6Achr11

73471611

-MRPL48chr11

73516072

+
5CDS-5UTRENST00000336083ENST00000398483RAB6Achr11

73471611

-MRPL48chr11

73516072

+
5CDS-5UTRENST00000336083ENST00000542303RAB6Achr11

73471611

-MRPL48chr11

73516072

+
5CDS-intronENST00000336083ENST00000314282RAB6Achr11

73471611

-MRPL48chr11

73516072

+
intron-3CDSENST00000536566ENST00000310614RAB6Achr11

73471611

-MRPL48chr11

73516072

+
intron-5UTRENST00000536566ENST00000535529RAB6Achr11

73471611

-MRPL48chr11

73516072

+
intron-5UTRENST00000536566ENST00000411840RAB6Achr11

73471611

-MRPL48chr11

73516072

+
intron-5UTRENST00000536566ENST00000398483RAB6Achr11

73471611

-MRPL48chr11

73516072

+
intron-5UTRENST00000536566ENST00000542303RAB6Achr11

73471611

-MRPL48chr11

73516072

+
intron-intronENST00000536566ENST00000314282RAB6Achr11

73471611

-MRPL48chr11

73516072

+
In-frameENST00000541588ENST00000310614RAB6Achr11

73471611

-MRPL48chr11

73516072

+
5CDS-5UTRENST00000541588ENST00000535529RAB6Achr11

73471611

-MRPL48chr11

73516072

+
5CDS-5UTRENST00000541588ENST00000411840RAB6Achr11

73471611

-MRPL48chr11

73516072

+
5CDS-5UTRENST00000541588ENST00000398483RAB6Achr11

73471611

-MRPL48chr11

73516072

+
5CDS-5UTRENST00000541588ENST00000542303RAB6Achr11

73471611

-MRPL48chr11

73516072

+
5CDS-intronENST00000541588ENST00000314282RAB6Achr11

73471611

-MRPL48chr11

73516072

+
Frame-shiftENST00000310653ENST00000310614RAB6Achr11

73471611

-MRPL48chr11

73536753

+
Frame-shiftENST00000310653ENST00000535529RAB6Achr11

73471611

-MRPL48chr11

73536753

+
5CDS-5UTRENST00000310653ENST00000411840RAB6Achr11

73471611

-MRPL48chr11

73536753

+
5CDS-5UTRENST00000310653ENST00000398483RAB6Achr11

73471611

-MRPL48chr11

73536753

+
5CDS-5UTRENST00000310653ENST00000542303RAB6Achr11

73471611

-MRPL48chr11

73536753

+
5CDS-intronENST00000310653ENST00000314282RAB6Achr11

73471611

-MRPL48chr11

73536753

+
Frame-shiftENST00000336083ENST00000310614RAB6Achr11

73471611

-MRPL48chr11

73536753

+
Frame-shiftENST00000336083ENST00000535529RAB6Achr11

73471611

-MRPL48chr11

73536753

+
5CDS-5UTRENST00000336083ENST00000411840RAB6Achr11

73471611

-MRPL48chr11

73536753

+
5CDS-5UTRENST00000336083ENST00000398483RAB6Achr11

73471611

-MRPL48chr11

73536753

+
5CDS-5UTRENST00000336083ENST00000542303RAB6Achr11

73471611

-MRPL48chr11

73536753

+
5CDS-intronENST00000336083ENST00000314282RAB6Achr11

73471611

-MRPL48chr11

73536753

+
intron-3CDSENST00000536566ENST00000310614RAB6Achr11

73471611

-MRPL48chr11

73536753

+
intron-3CDSENST00000536566ENST00000535529RAB6Achr11

73471611

-MRPL48chr11

73536753

+
intron-5UTRENST00000536566ENST00000411840RAB6Achr11

73471611

-MRPL48chr11

73536753

+
intron-5UTRENST00000536566ENST00000398483RAB6Achr11

73471611

-MRPL48chr11

73536753

+
intron-5UTRENST00000536566ENST00000542303RAB6Achr11

73471611

-MRPL48chr11

73536753

+
intron-intronENST00000536566ENST00000314282RAB6Achr11

73471611

-MRPL48chr11

73536753

+
Frame-shiftENST00000541588ENST00000310614RAB6Achr11

73471611

-MRPL48chr11

73536753

+
Frame-shiftENST00000541588ENST00000535529RAB6Achr11

73471611

-MRPL48chr11

73536753

+
5CDS-5UTRENST00000541588ENST00000411840RAB6Achr11

73471611

-MRPL48chr11

73536753

+
5CDS-5UTRENST00000541588ENST00000398483RAB6Achr11

73471611

-MRPL48chr11

73536753

+
5CDS-5UTRENST00000541588ENST00000542303RAB6Achr11

73471611

-MRPL48chr11

73536753

+
5CDS-intronENST00000541588ENST00000314282RAB6Achr11

73471611

-MRPL48chr11

73536753

+
intron-intronENST00000310653ENST00000310614RAB6Achr11

73420989

-MRPL48chr11

73505051

-
intron-intronENST00000310653ENST00000535529RAB6Achr11

73420989

-MRPL48chr11

73505051

-
intron-intronENST00000310653ENST00000411840RAB6Achr11

73420989

-MRPL48chr11

73505051

-
intron-intronENST00000310653ENST00000398483RAB6Achr11

73420989

-MRPL48chr11

73505051

-
intron-intronENST00000310653ENST00000542303RAB6Achr11

73420989

-MRPL48chr11

73505051

-
intron-intronENST00000310653ENST00000314282RAB6Achr11

73420989

-MRPL48chr11

73505051

-
intron-intronENST00000336083ENST00000310614RAB6Achr11

73420989

-MRPL48chr11

73505051

-
intron-intronENST00000336083ENST00000535529RAB6Achr11

73420989

-MRPL48chr11

73505051

-
intron-intronENST00000336083ENST00000411840RAB6Achr11

73420989

-MRPL48chr11

73505051

-
intron-intronENST00000336083ENST00000398483RAB6Achr11

73420989

-MRPL48chr11

73505051

-
intron-intronENST00000336083ENST00000542303RAB6Achr11

73420989

-MRPL48chr11

73505051

-
intron-intronENST00000336083ENST00000314282RAB6Achr11

73420989

-MRPL48chr11

73505051

-
intron-intronENST00000536566ENST00000310614RAB6Achr11

73420989

-MRPL48chr11

73505051

-
intron-intronENST00000536566ENST00000535529RAB6Achr11

73420989

-MRPL48chr11

73505051

-
intron-intronENST00000536566ENST00000411840RAB6Achr11

73420989

-MRPL48chr11

73505051

-
intron-intronENST00000536566ENST00000398483RAB6Achr11

73420989

-MRPL48chr11

73505051

-
intron-intronENST00000536566ENST00000542303RAB6Achr11

73420989

-MRPL48chr11

73505051

-
intron-intronENST00000536566ENST00000314282RAB6Achr11

73420989

-MRPL48chr11

73505051

-
intron-intronENST00000541588ENST00000310614RAB6Achr11

73420989

-MRPL48chr11

73505051

-
intron-intronENST00000541588ENST00000535529RAB6Achr11

73420989

-MRPL48chr11

73505051

-
intron-intronENST00000541588ENST00000411840RAB6Achr11

73420989

-MRPL48chr11

73505051

-
intron-intronENST00000541588ENST00000398483RAB6Achr11

73420989

-MRPL48chr11

73505051

-
intron-intronENST00000541588ENST00000542303RAB6Achr11

73420989

-MRPL48chr11

73505051

-
intron-intronENST00000541588ENST00000314282RAB6Achr11

73420989

-MRPL48chr11

73505051

-
intron-intronENST00000310653ENST00000310614RAB6Achr11

73421004

-MRPL48chr11

73505051

-
intron-intronENST00000310653ENST00000535529RAB6Achr11

73421004

-MRPL48chr11

73505051

-
intron-intronENST00000310653ENST00000411840RAB6Achr11

73421004

-MRPL48chr11

73505051

-
intron-intronENST00000310653ENST00000398483RAB6Achr11

73421004

-MRPL48chr11

73505051

-
intron-intronENST00000310653ENST00000542303RAB6Achr11

73421004

-MRPL48chr11

73505051

-
intron-intronENST00000310653ENST00000314282RAB6Achr11

73421004

-MRPL48chr11

73505051

-
intron-intronENST00000336083ENST00000310614RAB6Achr11

73421004

-MRPL48chr11

73505051

-
intron-intronENST00000336083ENST00000535529RAB6Achr11

73421004

-MRPL48chr11

73505051

-
intron-intronENST00000336083ENST00000411840RAB6Achr11

73421004

-MRPL48chr11

73505051

-
intron-intronENST00000336083ENST00000398483RAB6Achr11

73421004

-MRPL48chr11

73505051

-
intron-intronENST00000336083ENST00000542303RAB6Achr11

73421004

-MRPL48chr11

73505051

-
intron-intronENST00000336083ENST00000314282RAB6Achr11

73421004

-MRPL48chr11

73505051

-
intron-intronENST00000536566ENST00000310614RAB6Achr11

73421004

-MRPL48chr11

73505051

-
intron-intronENST00000536566ENST00000535529RAB6Achr11

73421004

-MRPL48chr11

73505051

-
intron-intronENST00000536566ENST00000411840RAB6Achr11

73421004

-MRPL48chr11

73505051

-
intron-intronENST00000536566ENST00000398483RAB6Achr11

73421004

-MRPL48chr11

73505051

-
intron-intronENST00000536566ENST00000542303RAB6Achr11

73421004

-MRPL48chr11

73505051

-
intron-intronENST00000536566ENST00000314282RAB6Achr11

73421004

-MRPL48chr11

73505051

-
intron-intronENST00000541588ENST00000310614RAB6Achr11

73421004

-MRPL48chr11

73505051

-
intron-intronENST00000541588ENST00000535529RAB6Achr11

73421004

-MRPL48chr11

73505051

-
intron-intronENST00000541588ENST00000411840RAB6Achr11

73421004

-MRPL48chr11

73505051

-
intron-intronENST00000541588ENST00000398483RAB6Achr11

73421004

-MRPL48chr11

73505051

-
intron-intronENST00000541588ENST00000542303RAB6Achr11

73421004

-MRPL48chr11

73505051

-
intron-intronENST00000541588ENST00000314282RAB6Achr11

73421004

-MRPL48chr11

73505051

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for RAB6A-MRPL48


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RAB6Achr1173471610-MRPL48chr1173516071+1.08E-060.9999989
RAB6Achr1173471610-MRPL48chr1173516071+1.08E-060.9999989
RAB6Achr1173471610-MRPL48chr1173536752+7.89E-091
RAB6Achr1173471610-MRPL48chr1173516071+1.08E-060.9999989
RAB6Achr1173471610-MRPL48chr1173516071+1.08E-060.9999989
RAB6Achr1173471610-MRPL48chr1173536752+7.89E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for RAB6A-MRPL48


check button Go to

FGviewer for the breakpoints of chr11:73471610-chr11:73516071

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MRPL48

Q96GC5

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMRPL48chr11:73471610chr11:73516071ENST000003106140869_747.0213.0Compositional biasNote=Poly-Lys
TgeneMRPL48chr11:73471611chr11:73516072ENST000003106140869_747.0213.0Compositional biasNote=Poly-Lys

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAB6Achr11:73471610chr11:73516071ENST00000310653-1842_5023.333333333333332209.0MotifEffector region
HgeneRAB6Achr11:73471610chr11:73516071ENST00000336083-1842_5023.333333333333332209.0MotifEffector region
HgeneRAB6Achr11:73471610chr11:73516071ENST00000536566-1842_500176.0MotifEffector region
HgeneRAB6Achr11:73471610chr11:73516071ENST00000541588-1542_5023.333333333333332105.0MotifEffector region
HgeneRAB6Achr11:73471611chr11:73516072ENST00000310653-1842_5023.333333333333332209.0MotifEffector region
HgeneRAB6Achr11:73471611chr11:73516072ENST00000336083-1842_5023.333333333333332209.0MotifEffector region
HgeneRAB6Achr11:73471611chr11:73516072ENST00000536566-1842_500176.0MotifEffector region
HgeneRAB6Achr11:73471611chr11:73516072ENST00000541588-1542_5023.333333333333332105.0MotifEffector region
HgeneRAB6Achr11:73471610chr11:73516071ENST00000310653-18126_12923.333333333333332209.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471610chr11:73516071ENST00000310653-18156_15823.333333333333332209.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471610chr11:73516071ENST00000310653-1820_2823.333333333333332209.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471610chr11:73516071ENST00000310653-1868_7223.333333333333332209.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471610chr11:73516071ENST00000336083-18126_12923.333333333333332209.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471610chr11:73516071ENST00000336083-18156_15823.333333333333332209.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471610chr11:73516071ENST00000336083-1820_2823.333333333333332209.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471610chr11:73516071ENST00000336083-1868_7223.333333333333332209.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471610chr11:73516071ENST00000536566-18126_1290176.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471610chr11:73516071ENST00000536566-18156_1580176.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471610chr11:73516071ENST00000536566-1820_280176.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471610chr11:73516071ENST00000536566-1868_720176.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471610chr11:73516071ENST00000541588-15126_12923.333333333333332105.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471610chr11:73516071ENST00000541588-15156_15823.333333333333332105.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471610chr11:73516071ENST00000541588-1520_2823.333333333333332105.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471610chr11:73516071ENST00000541588-1568_7223.333333333333332105.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471611chr11:73516072ENST00000310653-18126_12923.333333333333332209.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471611chr11:73516072ENST00000310653-18156_15823.333333333333332209.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471611chr11:73516072ENST00000310653-1820_2823.333333333333332209.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471611chr11:73516072ENST00000310653-1868_7223.333333333333332209.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471611chr11:73516072ENST00000336083-18126_12923.333333333333332209.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471611chr11:73516072ENST00000336083-18156_15823.333333333333332209.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471611chr11:73516072ENST00000336083-1820_2823.333333333333332209.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471611chr11:73516072ENST00000336083-1868_7223.333333333333332209.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471611chr11:73516072ENST00000536566-18126_1290176.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471611chr11:73516072ENST00000536566-18156_1580176.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471611chr11:73516072ENST00000536566-1820_280176.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471611chr11:73516072ENST00000536566-1868_720176.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471611chr11:73516072ENST00000541588-15126_12923.333333333333332105.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471611chr11:73516072ENST00000541588-15156_15823.333333333333332105.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471611chr11:73516072ENST00000541588-1520_2823.333333333333332105.0Nucleotide bindingGTP
HgeneRAB6Achr11:73471611chr11:73516072ENST00000541588-1568_7223.333333333333332105.0Nucleotide bindingGTP


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Fusion Gene Sequence for RAB6A-MRPL48


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for RAB6A-MRPL48


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RAB6A-MRPL48


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RAB6A-MRPL48


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource