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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RAD21-TPM2 (FusionGDB2 ID:71254)

Fusion Gene Summary for RAD21-TPM2

check button Fusion gene summary
Fusion gene informationFusion gene name: RAD21-TPM2
Fusion gene ID: 71254
HgeneTgene
Gene symbol

RAD21

TPM2

Gene ID

5885

7169

Gene nameRAD21 cohesin complex componenttropomyosin 2
SynonymsCDLS4|HR21|HRAD21|MCD1|MGS|NXP1|SCC1|hHR21AMCD1|DA1|DA2B|DA2B4|HEL-S-273|NEM4|TMSB
Cytomap

8q24.11

9p13.3

Type of geneprotein-codingprotein-coding
Descriptiondouble-strand-break repair protein rad21 homologNXP-1RAD21 homologSCC1 homologkleisinnuclear matrix protein 1protein involved in DNA double-strand break repairsister chromatid cohesion 1tropomyosin beta chainepididymis secretory protein Li 273nemaline myopathy type 4tropomyosin 2 (beta)
Modification date2020032720200328
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000297338, ENST00000523986, 
ENST00000517749, ENST00000518055, 
ENST00000523547, 		ENST00000378300, 
ENST00000378292, ENST00000329305, 
ENST00000360958, 
Fusion gene scores* DoF score11 X 23 X 9=227717 X 13 X 5=1105
# samples 2017
** MAII scorelog2(20/2277*10)=-3.5090623863619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1105*10)=-2.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAD21 [Title/Abstract] AND TPM2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRAD21(117862857)-TPM2(35685548), # samples:1
Anticipated loss of major functional domain due to fusion event.RAD21-TPM2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
RAD21-TPM2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAD21

GO:0006357

regulation of transcription by RNA polymerase II

19468298

TgeneTPM2

GO:0043462

regulation of ATPase activity

17194691


check buttonFusion gene breakpoints across RAD21 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TPM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-KD-A5QU-01ARAD21chr8

117862857

-TPM2chr9

35685548

-


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Fusion Gene ORF analysis for RAD21-TPM2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000297338ENST00000378300RAD21chr8

117862857

-TPM2chr9

35685548

-
In-frameENST00000297338ENST00000378292RAD21chr8

117862857

-TPM2chr9

35685548

-
In-frameENST00000297338ENST00000329305RAD21chr8

117862857

-TPM2chr9

35685548

-
In-frameENST00000297338ENST00000360958RAD21chr8

117862857

-TPM2chr9

35685548

-
Frame-shiftENST00000523986ENST00000378300RAD21chr8

117862857

-TPM2chr9

35685548

-
Frame-shiftENST00000523986ENST00000378292RAD21chr8

117862857

-TPM2chr9

35685548

-
Frame-shiftENST00000523986ENST00000329305RAD21chr8

117862857

-TPM2chr9

35685548

-
Frame-shiftENST00000523986ENST00000360958RAD21chr8

117862857

-TPM2chr9

35685548

-
intron-3CDSENST00000517749ENST00000378300RAD21chr8

117862857

-TPM2chr9

35685548

-
intron-3CDSENST00000517749ENST00000378292RAD21chr8

117862857

-TPM2chr9

35685548

-
intron-3CDSENST00000517749ENST00000329305RAD21chr8

117862857

-TPM2chr9

35685548

-
intron-3CDSENST00000517749ENST00000360958RAD21chr8

117862857

-TPM2chr9

35685548

-
Frame-shiftENST00000518055ENST00000378300RAD21chr8

117862857

-TPM2chr9

35685548

-
Frame-shiftENST00000518055ENST00000378292RAD21chr8

117862857

-TPM2chr9

35685548

-
Frame-shiftENST00000518055ENST00000329305RAD21chr8

117862857

-TPM2chr9

35685548

-
Frame-shiftENST00000518055ENST00000360958RAD21chr8

117862857

-TPM2chr9

35685548

-
intron-3CDSENST00000523547ENST00000378300RAD21chr8

117862857

-TPM2chr9

35685548

-
intron-3CDSENST00000523547ENST00000378292RAD21chr8

117862857

-TPM2chr9

35685548

-
intron-3CDSENST00000523547ENST00000329305RAD21chr8

117862857

-TPM2chr9

35685548

-
intron-3CDSENST00000523547ENST00000360958RAD21chr8

117862857

-TPM2chr9

35685548

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000297338RAD21chr8117862857-ENST00000378300TPM2chr935685548-321919082881946552
ENST00000297338RAD21chr8117862857-ENST00000378292TPM2chr935685548-247819082881946552
ENST00000297338RAD21chr8117862857-ENST00000329305TPM2chr935685548-245619082881946552
ENST00000297338RAD21chr8117862857-ENST00000360958TPM2chr935685548-261819082881946552

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000297338ENST00000378300RAD21chr8117862857-TPM2chr935685548-0.0024426920.9975573
ENST00000297338ENST00000378292RAD21chr8117862857-TPM2chr935685548-0.0037743880.9962256
ENST00000297338ENST00000329305RAD21chr8117862857-TPM2chr935685548-0.0032968320.9967032
ENST00000297338ENST00000360958RAD21chr8117862857-TPM2chr935685548-0.0046437170.99535626

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Fusion Genomic Features for RAD21-TPM2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RAD21-TPM2


check button Go to

FGviewer for the breakpoints of chr8:117862857-chr9:35685548

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAD21chr8:117862857chr9:35685548ENST00000297338-1214469_510540.0632.0Compositional biasNote=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTPM2chr8:117862857chr9:35685548ENST00000360958291_284124.66666666666667285.0Coiled coilOntology_term=ECO:0000250
TgeneTPM2chr8:117862857chr9:35685548ENST00000378292291_284124.66666666666667285.0Coiled coilOntology_term=ECO:0000250


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Fusion Gene Sequence for RAD21-TPM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000297338_ENST00000378300_TCGA-KD-A5QU-01A_RAD21_chr8_117862857_-_TPM2_chr9_35685548_length(transcript)=3219nt_BP=1908nt
AGGCGCACAGGTACCATTTTGACCGTAAACATCCTGCCGATTTGAACCGAGGATTTGGGCGGCAGGAAGAGCCGCGGCGTAACGGCAGCC
ATCTTGTTTGTTTGAGTGAATCGGAAAGGAGGCGCCGGCTGTGGCGGCGGCGGGAGCTGCTCGGAAGCTACACCTCGCAAGGGCTCCCCC
CTTTCCCCACCCCCTCCCCCGACCCTTTTCCCCTCCCCGGGCCACCCAGCCCGCCCAACTCCCAGCGGAGAGCAAGGTTTTCTTCTGTTT
TCATAGCCAGCCAGAACAATGTTCTACGCACATTTTGTTCTCAGTAAAAGAGGGCCTCTGGCCAAAATTTGGCTAGCGGCCCATTGGGAT
AAGAAGCTAACCAAAGCCCATGTGTTCGAGTGTAATTTAGAGAGCAGCGTGGAGAGTATCATCTCACCAAAGGTGAAAATGGCATTACGG
ACATCAGGACATCTCTTACTGGGAGTAGTTCGAATCTATCACAGGAAAGCCAAATACCTTCTTGCAGACTGTAATGAAGCATTCATTAAG
ATAAAGATGGCTTTTCGGCCAGGTGTGGTTGACCTGCCTGAGGAAAATCGGGAAGCAGCTTATAATGCCATTACTTTACCTGAAGAATTT
CATGACTTTGATCAGCCACTGCCTGACTTAGATGACATCGATGTGGCCCAGCAGTTCAGCTTGAATCAGAGTAGAGTGGAAGAGATAACC
ATGAGAGAAGAAGTTGGGAACATCAGTATTTTACAAGAAAATGATTTTGGTGATTTTGGAATGGATGATCGTGAGATAATGAGAGAAGGC
AGTGCTTTTGAGGATGACGACATGTTAGTAAGCACTACTACTTCTAACCTCCTATTAGAGTCTGAACAGAGCACCAGCAATCTGAATGAG
AAAATTAACCATTTAGAATATGAAGATCAATATAAGGATGATAATTTTGGAGAAGGAAATGATGGTGGAATATTAGATGACAAACTTATT
AGTAATAATGATGGCGGTATCTTTGATGATCCCCCTGCCCTCTCTGAGGCAGGGGTGATGTTGCCAGAGCAGCCTGCACATGACGATATG
GATGAGGATGATAATGTATCAATGGGTGGGCCTGATAGTCCTGATTCAGTGGATCCCGTTGAACCAATGCCAACCATGACTGATCAAACA
ACACTTGTTCCAAATGAGGAAGAAGCATTTGCATTGGAGCCTATTGATATAACTGTTAAAGAAACAAAAGCCAAGAGGAAGAGGAAGCTA
ATTGTTGACAGTGTCAAAGAGTTGGATAGCAAGACAATTAGAGCCCAACTTAGTGATTATTCAGATATTGTTACTACTTTGGATCTGGCA
CCGCCCACCAAGAAATTGATGATGTGGAAAGAGACAGGAGGAGTAGAAAAACTGTTTTCTTTACCTGCTCAGCCTTTGTGGAATAACAGA
CTACTGAAGCTCTTTACACGCTGTCTTACACCGCTTGTACCAGAAGACCTTAGAAAAAGGAGGAAAGGAGGAGAGGCAGATAATTTGGAT
GAATTCCTCAAAGAATTTGAAAATCCAGAGGTTCCTAGAGAGGACCAGCAACAGCAGCATCAGCAGCGTGATGTTATCGATGAGCCCATT
ATTGAAGAGCCAAGCCGCCTCCAGGAGTCAGTGATGGAGGCCAGCAGAACAAACATAGATGAGTCAGCTATGCCTCCACCACCACCTCAG
GGAGTTAAGCGAAAAGCTGGACAAATTGACCCAGAGCCTGTGATGCCTCCTCAGCAGGTAGAGCAGATGGAAATACCACCTGTAGAGCTT
CCCCCAGAAGAACCTCCAAATATCTGTCAGCTAATACCAGAGTTAGAACTTCTGCCAGAAAAAGAGAAGGAGAAAGAGAAGGAAAAAGAA
GATGATGAAGAGGAAGAGAGGAATGAAGGTCATCGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAACTGCAGGAGATGCAGCTGAA
GGAGGCCAAGCACATCGCTGAGGATTCAGACCGCAAATATGAAGAGGTGGCCAGGAAGCTGGTGATCCTGGAAGGAGAGCTGGAGCGCTC
GGAGGAGAGGGCTGAGGTGGCCGAGAGTAAATGTGGGGACCTAGAGGAGGAGCTGAAAATTGTTACCAACAACTTGAAATCCCTGGAGGC
CCAGGCGGACAAGTATTCCACCAAAGAAGATAAATATGAAGAGGAGATCAAACTGTTGGAGGAGAAGCTGAAGGAGGCTGAGACCCGAGC
AGAGTTTGCCGAGAGGTCTGTGGCAAAGTTGGAGAAAACCATCGATGACCTAGAAGAGAGCACCTCTATCGCCACCACGGAGCACTGGTT
CACTCCTGACACCCTGGCACTTACTGACACCCCCAGCCCCTGCACTGAGCCCACCCACAAAACACCATGGCCCACGCTGAAACCCCTCTG
CACAGGCACTCCCTGGCTGTCGCTCTCTGATTCACCACTGCATGTGGGCACGTGTGGCCCCATCAAACCATGACCGCCTCTGGTGCCAAT
CCCTGACCTCAGAGCACTTAGCTGGGGTTCCAGGATCAAACAGAGTGACTGGAAAGGAAGTAGGGTGGTGAGGTGCAGGACAGGGGCAAG
AAGGTTGCAAAAGGTCTGGAATGGAGCTTGGAAAAATGTTGGATATCAGCAACATGGGGCTTTCACTGCAGCAGCAGGTCTGTTTTCTAC
CTCAAGTCTGTCTGTCTGGCCCTTCCTTTCCTGGCGCAGTCTTTGTCTTACCTTCTGTCTCCAACTTCCTTAAACCTTCTAAAGAAGAGG
ATAAAGTAGTTTATGACTCAGCCCTCCCCACCCCACCTCTATGACCCCAAGGCCTTGAGTGAGGCATCCACGTCCGTCCTGTTCCCCTCA
TCCTAGTCAGTCCATCTGTTTGTCCCTGCCAAGGGGCCCTGAGGTCCGTGAATGCATGTGTCTTCCTTGACCCACTCCATGTCTATATGT
CACCTTCCCCTGGCCCTGCCTCCCCACGTCTCCCCCTTGTGTCTCCCTTCTCCCTCACCTGCTGCTTCCCCTCACAGAGACCTTGGCCAG
TGCCAAGGAGGAGAACGTCGAGATTCACCAGACCTTGGACCAGACCCTGCTGGAACTCAACAACCTGTGAGGGCCAGCCCCACCCCCAGC

>In-frame_ENST00000297338_ENST00000378300_TCGA-KD-A5QU-01A_RAD21_chr8_117862857_-_TPM2_chr9_35685548_length(amino acids)=552AA_start in transcript=288_stop in transcript=1946
MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVRIYHRKAKYLLADCNEAFIKIKMAFR
PGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMREGSAFEDD
DMLVSTTTSNLLLESEQSTSNLNEKINHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGGIFDDPPALSEAGVMLPEQPAHDDMDEDDNV
SMGGPDSPDSVDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKL
MMWKETGGVEKLFSLPAQPLWNNRLLKLFTRCLTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPREDQQQQHQQRDVIDEPIIEEPSR
LQESVMEASRTNIDESAMPPPPPQGVKRKAGQIDPEPVMPPQQVEQMEIPPVELPPEEPPNICQLIPELELLPEKEKEKEKEKEDDEEEE

--------------------------------------------------------------
>In-frame_ENST00000297338_ENST00000378292_TCGA-KD-A5QU-01A_RAD21_chr8_117862857_-_TPM2_chr9_35685548_length(transcript)=2478nt_BP=1908nt
AGGCGCACAGGTACCATTTTGACCGTAAACATCCTGCCGATTTGAACCGAGGATTTGGGCGGCAGGAAGAGCCGCGGCGTAACGGCAGCC
ATCTTGTTTGTTTGAGTGAATCGGAAAGGAGGCGCCGGCTGTGGCGGCGGCGGGAGCTGCTCGGAAGCTACACCTCGCAAGGGCTCCCCC
CTTTCCCCACCCCCTCCCCCGACCCTTTTCCCCTCCCCGGGCCACCCAGCCCGCCCAACTCCCAGCGGAGAGCAAGGTTTTCTTCTGTTT
TCATAGCCAGCCAGAACAATGTTCTACGCACATTTTGTTCTCAGTAAAAGAGGGCCTCTGGCCAAAATTTGGCTAGCGGCCCATTGGGAT
AAGAAGCTAACCAAAGCCCATGTGTTCGAGTGTAATTTAGAGAGCAGCGTGGAGAGTATCATCTCACCAAAGGTGAAAATGGCATTACGG
ACATCAGGACATCTCTTACTGGGAGTAGTTCGAATCTATCACAGGAAAGCCAAATACCTTCTTGCAGACTGTAATGAAGCATTCATTAAG
ATAAAGATGGCTTTTCGGCCAGGTGTGGTTGACCTGCCTGAGGAAAATCGGGAAGCAGCTTATAATGCCATTACTTTACCTGAAGAATTT
CATGACTTTGATCAGCCACTGCCTGACTTAGATGACATCGATGTGGCCCAGCAGTTCAGCTTGAATCAGAGTAGAGTGGAAGAGATAACC
ATGAGAGAAGAAGTTGGGAACATCAGTATTTTACAAGAAAATGATTTTGGTGATTTTGGAATGGATGATCGTGAGATAATGAGAGAAGGC
AGTGCTTTTGAGGATGACGACATGTTAGTAAGCACTACTACTTCTAACCTCCTATTAGAGTCTGAACAGAGCACCAGCAATCTGAATGAG
AAAATTAACCATTTAGAATATGAAGATCAATATAAGGATGATAATTTTGGAGAAGGAAATGATGGTGGAATATTAGATGACAAACTTATT
AGTAATAATGATGGCGGTATCTTTGATGATCCCCCTGCCCTCTCTGAGGCAGGGGTGATGTTGCCAGAGCAGCCTGCACATGACGATATG
GATGAGGATGATAATGTATCAATGGGTGGGCCTGATAGTCCTGATTCAGTGGATCCCGTTGAACCAATGCCAACCATGACTGATCAAACA
ACACTTGTTCCAAATGAGGAAGAAGCATTTGCATTGGAGCCTATTGATATAACTGTTAAAGAAACAAAAGCCAAGAGGAAGAGGAAGCTA
ATTGTTGACAGTGTCAAAGAGTTGGATAGCAAGACAATTAGAGCCCAACTTAGTGATTATTCAGATATTGTTACTACTTTGGATCTGGCA
CCGCCCACCAAGAAATTGATGATGTGGAAAGAGACAGGAGGAGTAGAAAAACTGTTTTCTTTACCTGCTCAGCCTTTGTGGAATAACAGA
CTACTGAAGCTCTTTACACGCTGTCTTACACCGCTTGTACCAGAAGACCTTAGAAAAAGGAGGAAAGGAGGAGAGGCAGATAATTTGGAT
GAATTCCTCAAAGAATTTGAAAATCCAGAGGTTCCTAGAGAGGACCAGCAACAGCAGCATCAGCAGCGTGATGTTATCGATGAGCCCATT
ATTGAAGAGCCAAGCCGCCTCCAGGAGTCAGTGATGGAGGCCAGCAGAACAAACATAGATGAGTCAGCTATGCCTCCACCACCACCTCAG
GGAGTTAAGCGAAAAGCTGGACAAATTGACCCAGAGCCTGTGATGCCTCCTCAGCAGGTAGAGCAGATGGAAATACCACCTGTAGAGCTT
CCCCCAGAAGAACCTCCAAATATCTGTCAGCTAATACCAGAGTTAGAACTTCTGCCAGAAAAAGAGAAGGAGAAAGAGAAGGAAAAAGAA
GATGATGAAGAGGAAGAGAGGAATGAAGGTCATCGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAACTGCAGGAGATGCAGCTGAA
GGAGGCCAAGCACATCGCTGAGGATTCAGACCGCAAATATGAAGAGGTGGCCAGGAAGCTGGTGATCCTGGAAGGAGAGCTGGAGCGCTC
GGAGGAGAGGGCTGAGGTGGCCGAGAGCCGAGCCAGACAGCTGGAGGAGGAACTTCGAACCATGGACCAGGCCCTCAAGTCCCTGATGGC
CTCAGAGGAGGAGTATTCCACCAAAGAAGATAAATATGAAGAGGAGATCAAACTGTTGGAGGAGAAGCTGAAGGAGGCTGAGACCCGAGC
AGAGTTTGCCGAGAGGTCTGTGGCAAAGTTGGAGAAAACCATCGATGACCTAGAAGAGACCTTGGCCAGTGCCAAGGAGGAGAACGTCGA
GATTCACCAGACCTTGGACCAGACCCTGCTGGAACTCAACAACCTGTGAGGGCCAGCCCCACCCCCAGCCAGGCTATGGTTGCCACCCCA

>In-frame_ENST00000297338_ENST00000378292_TCGA-KD-A5QU-01A_RAD21_chr8_117862857_-_TPM2_chr9_35685548_length(amino acids)=552AA_start in transcript=288_stop in transcript=1946
MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVRIYHRKAKYLLADCNEAFIKIKMAFR
PGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMREGSAFEDD
DMLVSTTTSNLLLESEQSTSNLNEKINHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGGIFDDPPALSEAGVMLPEQPAHDDMDEDDNV
SMGGPDSPDSVDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKL
MMWKETGGVEKLFSLPAQPLWNNRLLKLFTRCLTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPREDQQQQHQQRDVIDEPIIEEPSR
LQESVMEASRTNIDESAMPPPPPQGVKRKAGQIDPEPVMPPQQVEQMEIPPVELPPEEPPNICQLIPELELLPEKEKEKEKEKEDDEEEE

--------------------------------------------------------------
>In-frame_ENST00000297338_ENST00000329305_TCGA-KD-A5QU-01A_RAD21_chr8_117862857_-_TPM2_chr9_35685548_length(transcript)=2456nt_BP=1908nt
AGGCGCACAGGTACCATTTTGACCGTAAACATCCTGCCGATTTGAACCGAGGATTTGGGCGGCAGGAAGAGCCGCGGCGTAACGGCAGCC
ATCTTGTTTGTTTGAGTGAATCGGAAAGGAGGCGCCGGCTGTGGCGGCGGCGGGAGCTGCTCGGAAGCTACACCTCGCAAGGGCTCCCCC
CTTTCCCCACCCCCTCCCCCGACCCTTTTCCCCTCCCCGGGCCACCCAGCCCGCCCAACTCCCAGCGGAGAGCAAGGTTTTCTTCTGTTT
TCATAGCCAGCCAGAACAATGTTCTACGCACATTTTGTTCTCAGTAAAAGAGGGCCTCTGGCCAAAATTTGGCTAGCGGCCCATTGGGAT
AAGAAGCTAACCAAAGCCCATGTGTTCGAGTGTAATTTAGAGAGCAGCGTGGAGAGTATCATCTCACCAAAGGTGAAAATGGCATTACGG
ACATCAGGACATCTCTTACTGGGAGTAGTTCGAATCTATCACAGGAAAGCCAAATACCTTCTTGCAGACTGTAATGAAGCATTCATTAAG
ATAAAGATGGCTTTTCGGCCAGGTGTGGTTGACCTGCCTGAGGAAAATCGGGAAGCAGCTTATAATGCCATTACTTTACCTGAAGAATTT
CATGACTTTGATCAGCCACTGCCTGACTTAGATGACATCGATGTGGCCCAGCAGTTCAGCTTGAATCAGAGTAGAGTGGAAGAGATAACC
ATGAGAGAAGAAGTTGGGAACATCAGTATTTTACAAGAAAATGATTTTGGTGATTTTGGAATGGATGATCGTGAGATAATGAGAGAAGGC
AGTGCTTTTGAGGATGACGACATGTTAGTAAGCACTACTACTTCTAACCTCCTATTAGAGTCTGAACAGAGCACCAGCAATCTGAATGAG
AAAATTAACCATTTAGAATATGAAGATCAATATAAGGATGATAATTTTGGAGAAGGAAATGATGGTGGAATATTAGATGACAAACTTATT
AGTAATAATGATGGCGGTATCTTTGATGATCCCCCTGCCCTCTCTGAGGCAGGGGTGATGTTGCCAGAGCAGCCTGCACATGACGATATG
GATGAGGATGATAATGTATCAATGGGTGGGCCTGATAGTCCTGATTCAGTGGATCCCGTTGAACCAATGCCAACCATGACTGATCAAACA
ACACTTGTTCCAAATGAGGAAGAAGCATTTGCATTGGAGCCTATTGATATAACTGTTAAAGAAACAAAAGCCAAGAGGAAGAGGAAGCTA
ATTGTTGACAGTGTCAAAGAGTTGGATAGCAAGACAATTAGAGCCCAACTTAGTGATTATTCAGATATTGTTACTACTTTGGATCTGGCA
CCGCCCACCAAGAAATTGATGATGTGGAAAGAGACAGGAGGAGTAGAAAAACTGTTTTCTTTACCTGCTCAGCCTTTGTGGAATAACAGA
CTACTGAAGCTCTTTACACGCTGTCTTACACCGCTTGTACCAGAAGACCTTAGAAAAAGGAGGAAAGGAGGAGAGGCAGATAATTTGGAT
GAATTCCTCAAAGAATTTGAAAATCCAGAGGTTCCTAGAGAGGACCAGCAACAGCAGCATCAGCAGCGTGATGTTATCGATGAGCCCATT
ATTGAAGAGCCAAGCCGCCTCCAGGAGTCAGTGATGGAGGCCAGCAGAACAAACATAGATGAGTCAGCTATGCCTCCACCACCACCTCAG
GGAGTTAAGCGAAAAGCTGGACAAATTGACCCAGAGCCTGTGATGCCTCCTCAGCAGGTAGAGCAGATGGAAATACCACCTGTAGAGCTT
CCCCCAGAAGAACCTCCAAATATCTGTCAGCTAATACCAGAGTTAGAACTTCTGCCAGAAAAAGAGAAGGAGAAAGAGAAGGAAAAAGAA
GATGATGAAGAGGAAGAGAGGAATGAAGGTCATCGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAACTGCAGGAGATGCAGCTGAA
GGAGGCCAAGCACATCGCTGAGGATTCAGACCGCAAATATGAAGAGGTGGCCAGGAAGCTGGTGATCCTGGAAGGAGAGCTGGAGCGCTC
GGAGGAGAGGGCTGAGGTGGCCGAGAGTAAATGTGGGGACCTAGAGGAGGAGCTGAAAATTGTTACCAACAACTTGAAATCCCTGGAGGC
CCAGGCGGACAAGTATTCCACCAAAGAAGATAAATATGAAGAGGAGATCAAACTGTTGGAGGAGAAGCTGAAGGAGGCTGAGACCCGAGC
AGAGTTTGCCGAGAGGTCTGTGGCAAAGTTGGAGAAAACCATCGATGACCTAGAAGAGACCTTGGCCAGTGCCAAGGAGGAGAACGTCGA
GATTCACCAGACCTTGGACCAGACCCTGCTGGAACTCAACAACCTGTGAGGGCCAGCCCCACCCCCAGCCAGGCTATGGTTGCCACCCCA

>In-frame_ENST00000297338_ENST00000329305_TCGA-KD-A5QU-01A_RAD21_chr8_117862857_-_TPM2_chr9_35685548_length(amino acids)=552AA_start in transcript=288_stop in transcript=1946
MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVRIYHRKAKYLLADCNEAFIKIKMAFR
PGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMREGSAFEDD
DMLVSTTTSNLLLESEQSTSNLNEKINHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGGIFDDPPALSEAGVMLPEQPAHDDMDEDDNV
SMGGPDSPDSVDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKL
MMWKETGGVEKLFSLPAQPLWNNRLLKLFTRCLTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPREDQQQQHQQRDVIDEPIIEEPSR
LQESVMEASRTNIDESAMPPPPPQGVKRKAGQIDPEPVMPPQQVEQMEIPPVELPPEEPPNICQLIPELELLPEKEKEKEKEKEDDEEEE

--------------------------------------------------------------
>In-frame_ENST00000297338_ENST00000360958_TCGA-KD-A5QU-01A_RAD21_chr8_117862857_-_TPM2_chr9_35685548_length(transcript)=2618nt_BP=1908nt
AGGCGCACAGGTACCATTTTGACCGTAAACATCCTGCCGATTTGAACCGAGGATTTGGGCGGCAGGAAGAGCCGCGGCGTAACGGCAGCC
ATCTTGTTTGTTTGAGTGAATCGGAAAGGAGGCGCCGGCTGTGGCGGCGGCGGGAGCTGCTCGGAAGCTACACCTCGCAAGGGCTCCCCC
CTTTCCCCACCCCCTCCCCCGACCCTTTTCCCCTCCCCGGGCCACCCAGCCCGCCCAACTCCCAGCGGAGAGCAAGGTTTTCTTCTGTTT
TCATAGCCAGCCAGAACAATGTTCTACGCACATTTTGTTCTCAGTAAAAGAGGGCCTCTGGCCAAAATTTGGCTAGCGGCCCATTGGGAT
AAGAAGCTAACCAAAGCCCATGTGTTCGAGTGTAATTTAGAGAGCAGCGTGGAGAGTATCATCTCACCAAAGGTGAAAATGGCATTACGG
ACATCAGGACATCTCTTACTGGGAGTAGTTCGAATCTATCACAGGAAAGCCAAATACCTTCTTGCAGACTGTAATGAAGCATTCATTAAG
ATAAAGATGGCTTTTCGGCCAGGTGTGGTTGACCTGCCTGAGGAAAATCGGGAAGCAGCTTATAATGCCATTACTTTACCTGAAGAATTT
CATGACTTTGATCAGCCACTGCCTGACTTAGATGACATCGATGTGGCCCAGCAGTTCAGCTTGAATCAGAGTAGAGTGGAAGAGATAACC
ATGAGAGAAGAAGTTGGGAACATCAGTATTTTACAAGAAAATGATTTTGGTGATTTTGGAATGGATGATCGTGAGATAATGAGAGAAGGC
AGTGCTTTTGAGGATGACGACATGTTAGTAAGCACTACTACTTCTAACCTCCTATTAGAGTCTGAACAGAGCACCAGCAATCTGAATGAG
AAAATTAACCATTTAGAATATGAAGATCAATATAAGGATGATAATTTTGGAGAAGGAAATGATGGTGGAATATTAGATGACAAACTTATT
AGTAATAATGATGGCGGTATCTTTGATGATCCCCCTGCCCTCTCTGAGGCAGGGGTGATGTTGCCAGAGCAGCCTGCACATGACGATATG
GATGAGGATGATAATGTATCAATGGGTGGGCCTGATAGTCCTGATTCAGTGGATCCCGTTGAACCAATGCCAACCATGACTGATCAAACA
ACACTTGTTCCAAATGAGGAAGAAGCATTTGCATTGGAGCCTATTGATATAACTGTTAAAGAAACAAAAGCCAAGAGGAAGAGGAAGCTA
ATTGTTGACAGTGTCAAAGAGTTGGATAGCAAGACAATTAGAGCCCAACTTAGTGATTATTCAGATATTGTTACTACTTTGGATCTGGCA
CCGCCCACCAAGAAATTGATGATGTGGAAAGAGACAGGAGGAGTAGAAAAACTGTTTTCTTTACCTGCTCAGCCTTTGTGGAATAACAGA
CTACTGAAGCTCTTTACACGCTGTCTTACACCGCTTGTACCAGAAGACCTTAGAAAAAGGAGGAAAGGAGGAGAGGCAGATAATTTGGAT
GAATTCCTCAAAGAATTTGAAAATCCAGAGGTTCCTAGAGAGGACCAGCAACAGCAGCATCAGCAGCGTGATGTTATCGATGAGCCCATT
ATTGAAGAGCCAAGCCGCCTCCAGGAGTCAGTGATGGAGGCCAGCAGAACAAACATAGATGAGTCAGCTATGCCTCCACCACCACCTCAG
GGAGTTAAGCGAAAAGCTGGACAAATTGACCCAGAGCCTGTGATGCCTCCTCAGCAGGTAGAGCAGATGGAAATACCACCTGTAGAGCTT
CCCCCAGAAGAACCTCCAAATATCTGTCAGCTAATACCAGAGTTAGAACTTCTGCCAGAAAAAGAGAAGGAGAAAGAGAAGGAAAAAGAA
GATGATGAAGAGGAAGAGAGGAATGAAGGTCATCGAAAACCGGGCCATGAAGGATGAGGAGAAGATGGAACTGCAGGAGATGCAGCTGAA
GGAGGCCAAGCACATCGCTGAGGATTCAGACCGCAAATATGAAGAGGTGGCCAGGAAGCTGGTGATCCTGGAAGGAGAGCTGGAGCGCTC
GGAGGAGAGGGCTGAGGTGGCCGAGAGTAAATGTGGGGACCTAGAGGAGGAGCTGAAAATTGTTACCAACAACTTGAAATCCCTGGAGGC
CCAGGCGGACAAGTATTCCACCAAAGAAGATAAATATGAAGAGGAGATCAAACTGTTGGAGGAGAAGCTGAAGGAGGCTGAGACCCGAGC
AGAGTTTGCCGAGAGGTCTGTGGCAAAGTTGGAGAAAACCATCGATGACCTAGAAGATGAAGTCTATGCCCAGAAGATGAAGTACAAGGC
CATTAGCGAGGAACTGGACAACGCACTCAATGACATCACCTCCCTCTGAGCCCCACGCCAGCGTGGCCACCTCAGCTCTCTTCTCTCCTC
TCCTTTCCATTCTCTCTATGGGGAGGGGAGCAGGCAGGAGGAGCAGAAATTGCCAACATTGCACAGCCAGGCTGGGAGCAGCCTAGGGAG
AGCCCCCATCATGCCCACCACCCACTCTGGCACTGGCTTCATCCTTTACCTATCCCCTTCCACCCTCCTTTGCTGCTTAATAAATTCTGA

>In-frame_ENST00000297338_ENST00000360958_TCGA-KD-A5QU-01A_RAD21_chr8_117862857_-_TPM2_chr9_35685548_length(amino acids)=552AA_start in transcript=288_stop in transcript=1946
MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVRIYHRKAKYLLADCNEAFIKIKMAFR
PGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMREGSAFEDD
DMLVSTTTSNLLLESEQSTSNLNEKINHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGGIFDDPPALSEAGVMLPEQPAHDDMDEDDNV
SMGGPDSPDSVDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKL
MMWKETGGVEKLFSLPAQPLWNNRLLKLFTRCLTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPREDQQQQHQQRDVIDEPIIEEPSR
LQESVMEASRTNIDESAMPPPPPQGVKRKAGQIDPEPVMPPQQVEQMEIPPVELPPEEPPNICQLIPELELLPEKEKEKEKEKEDDEEEE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RAD21-TPM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneRAD21chr8:117862857chr9:35685548ENST00000297338-1214362_403540.0632.0STAG1
HgeneRAD21chr8:117862857chr9:35685548ENST00000297338-1214287_403540.0632.0WAPL and PDS5B


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RAD21-TPM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RAD21-TPM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRAD21C0270972Cornelia De Lange Syndrome9CLINGEN;CTD_human;ORPHANET
HgeneRAD21C3553517CORNELIA DE LANGE SYNDROME 43GENOMICS_ENGLAND;UNIPROT
HgeneRAD21C0023466Leukemia, Monocytic, Chronic1CTD_human
HgeneRAD21C0023470Myeloid Leukemia1CTD_human
HgeneRAD21C1860789Leukemia, Megakaryoblastic, of Down Syndrome1CTD_human
HgeneRAD21C1969653MUNGAN SYNDROME1CTD_human;UNIPROT
TgeneTPM2C0220662ARTHROGRYPOSIS, DISTAL, TYPE 17CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneTPM2C1836447Nemaline myopathy 47CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneTPM2C1834523ARTHROGRYPOSIS, DISTAL, TYPE 2B3GENOMICS_ENGLAND;ORPHANET
TgeneTPM2C0546125Nemaline Myopathy, Childhood Onset2ORPHANET
TgeneTPM2C0003886Arthrogryposis1GENOMICS_ENGLAND
TgeneTPM2C0206157Myopathies, Nemaline1GENOMICS_ENGLAND
TgeneTPM2C0265213Distal arthrogryposis syndrome1GENOMICS_ENGLAND
TgeneTPM2C0265261Multiple pterygium syndrome1GENOMICS_ENGLAND
TgeneTPM2C0270960Congenital myopathy (disorder)1GENOMICS_ENGLAND
TgeneTPM2C0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneTPM2C0546264Congenital Fiber Type Disproportion1CTD_human;ORPHANET
TgeneTPM2C1852085Digitotalar Dysmorphism1ORPHANET
TgeneTPM2C3710589Cap Myopathy1ORPHANET