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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RAF1-EIF3L (FusionGDB2 ID:71370)

Fusion Gene Summary for RAF1-EIF3L

check button Fusion gene summary
Fusion gene informationFusion gene name: RAF1-EIF3L
Fusion gene ID: 71370
HgeneTgene
Gene symbol

RAF1

EIF3L

Gene ID

6037

51386

Gene nameribonuclease A family member 3eukaryotic translation initiation factor 3 subunit L
SynonymsECP|RAF1|RNS3EIF3EIP|EIF3S11|EIF3S6IP|HSPC021|HSPC025|MSTP005
Cytomap

14q11.2

22q13.1

Type of geneprotein-codingprotein-coding
Descriptioneosinophil cationic proteinRNase 3cytotoxic ribonucleaseribonuclease 3ribonuclease, RNase A family, 3eukaryotic translation initiation factor 3 subunit LeIEF associated protein HSPC021eukaryotic translation initiation factor 3 subunit 6-interacting proteineukaryotic translation initiation factor 3 subunit E-interacting protein
Modification date2020031320200322
UniProtAcc.

Q9Y262

Ensembl transtripts involved in fusion geneENST00000251849, ENST00000442415, 
ENST00000534997, ENST00000542177, 
ENST00000412331, ENST00000381683, 
ENST00000406934, ENST00000476955, 
Fusion gene scores* DoF score24 X 15 X 16=576010 X 13 X 6=780
# samples 2813
** MAII scorelog2(28/5760*10)=-4.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/780*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAF1 [Title/Abstract] AND EIF3L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRAF1(12653449)-EIF3L(38282772), # samples:1
RAF1(12660013)-EIF3L(38282771), # samples:1
Anticipated loss of major functional domain due to fusion event.RAF1-EIF3L seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
RAF1-EIF3L seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
RAF1-EIF3L seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
RAF1-EIF3L seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAF1

GO:0002227

innate immune response in mucosa

12860195

HgeneRAF1

GO:0019731

antibacterial humoral response

12860195

HgeneRAF1

GO:0043152

induction of bacterial agglutination

23992292

HgeneRAF1

GO:0045087

innate immune response

23992292

HgeneRAF1

GO:0050829

defense response to Gram-negative bacterium

23992292

HgeneRAF1

GO:0050830

defense response to Gram-positive bacterium

12860195|23992292

HgeneRAF1

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

12860195

TgeneEIF3L

GO:0006413

translational initiation

17581632

TgeneEIF3L

GO:0075525

viral translational termination-reinitiation

21347434


check buttonFusion gene breakpoints across RAF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across EIF3L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4DLBCTCGA-G8-6325-01ARAF1chr3

12653449

-EIF3Lchr22

38282772

+
ChimerDB4DLBCTCGA-G8-6325RAF1chr3

12660013

-EIF3Lchr22

38282771

+


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Fusion Gene ORF analysis for RAF1-EIF3L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000251849ENST00000412331RAF1chr3

12653449

-EIF3Lchr22

38282772

+
In-frameENST00000251849ENST00000381683RAF1chr3

12653449

-EIF3Lchr22

38282772

+
In-frameENST00000251849ENST00000406934RAF1chr3

12653449

-EIF3Lchr22

38282772

+
5CDS-intronENST00000251849ENST00000476955RAF1chr3

12653449

-EIF3Lchr22

38282772

+
In-frameENST00000442415ENST00000412331RAF1chr3

12653449

-EIF3Lchr22

38282772

+
In-frameENST00000442415ENST00000381683RAF1chr3

12653449

-EIF3Lchr22

38282772

+
In-frameENST00000442415ENST00000406934RAF1chr3

12653449

-EIF3Lchr22

38282772

+
5CDS-intronENST00000442415ENST00000476955RAF1chr3

12653449

-EIF3Lchr22

38282772

+
intron-3CDSENST00000534997ENST00000412331RAF1chr3

12653449

-EIF3Lchr22

38282772

+
intron-3CDSENST00000534997ENST00000381683RAF1chr3

12653449

-EIF3Lchr22

38282772

+
intron-3CDSENST00000534997ENST00000406934RAF1chr3

12653449

-EIF3Lchr22

38282772

+
intron-intronENST00000534997ENST00000476955RAF1chr3

12653449

-EIF3Lchr22

38282772

+
intron-3CDSENST00000542177ENST00000412331RAF1chr3

12653449

-EIF3Lchr22

38282772

+
intron-3CDSENST00000542177ENST00000381683RAF1chr3

12653449

-EIF3Lchr22

38282772

+
intron-3CDSENST00000542177ENST00000406934RAF1chr3

12653449

-EIF3Lchr22

38282772

+
intron-intronENST00000542177ENST00000476955RAF1chr3

12653449

-EIF3Lchr22

38282772

+
Frame-shiftENST00000251849ENST00000412331RAF1chr3

12660013

-EIF3Lchr22

38282771

+
Frame-shiftENST00000251849ENST00000381683RAF1chr3

12660013

-EIF3Lchr22

38282771

+
Frame-shiftENST00000251849ENST00000406934RAF1chr3

12660013

-EIF3Lchr22

38282771

+
5CDS-intronENST00000251849ENST00000476955RAF1chr3

12660013

-EIF3Lchr22

38282771

+
Frame-shiftENST00000442415ENST00000412331RAF1chr3

12660013

-EIF3Lchr22

38282771

+
Frame-shiftENST00000442415ENST00000381683RAF1chr3

12660013

-EIF3Lchr22

38282771

+
Frame-shiftENST00000442415ENST00000406934RAF1chr3

12660013

-EIF3Lchr22

38282771

+
5CDS-intronENST00000442415ENST00000476955RAF1chr3

12660013

-EIF3Lchr22

38282771

+
intron-3CDSENST00000534997ENST00000412331RAF1chr3

12660013

-EIF3Lchr22

38282771

+
intron-3CDSENST00000534997ENST00000381683RAF1chr3

12660013

-EIF3Lchr22

38282771

+
intron-3CDSENST00000534997ENST00000406934RAF1chr3

12660013

-EIF3Lchr22

38282771

+
intron-intronENST00000534997ENST00000476955RAF1chr3

12660013

-EIF3Lchr22

38282771

+
In-frameENST00000542177ENST00000412331RAF1chr3

12660013

-EIF3Lchr22

38282771

+
In-frameENST00000542177ENST00000381683RAF1chr3

12660013

-EIF3Lchr22

38282771

+
In-frameENST00000542177ENST00000406934RAF1chr3

12660013

-EIF3Lchr22

38282771

+
5CDS-intronENST00000542177ENST00000476955RAF1chr3

12660013

-EIF3Lchr22

38282771

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000251849RAF1chr312653449-ENST00000412331EIF3Lchr2238282772+182376010361425129
ENST00000251849RAF1chr312653449-ENST00000381683EIF3Lchr2238282772+895760440766108
ENST00000251849RAF1chr312653449-ENST00000406934EIF3Lchr2238282772+1046760440766108
ENST00000442415RAF1chr312653449-ENST00000412331EIF3Lchr2238282772+17456829581347129
ENST00000442415RAF1chr312653449-ENST00000381683EIF3Lchr2238282772+817682362688108
ENST00000442415RAF1chr312653449-ENST00000406934EIF3Lchr2238282772+968682362688108
ENST00000542177RAF1chr312660013-ENST00000412331EIF3Lchr2238282771+16015388141203129
ENST00000542177RAF1chr312660013-ENST00000381683EIF3Lchr2238282771+673538331657108
ENST00000542177RAF1chr312660013-ENST00000406934EIF3Lchr2238282771+824538331657108

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000251849ENST00000412331RAF1chr312653449-EIF3Lchr2238282772+0.1117206960.8882793
ENST00000251849ENST00000381683RAF1chr312653449-EIF3Lchr2238282772+0.084902090.9150979
ENST00000251849ENST00000406934RAF1chr312653449-EIF3Lchr2238282772+0.108614280.8913857
ENST00000442415ENST00000412331RAF1chr312653449-EIF3Lchr2238282772+0.116843190.8831568
ENST00000442415ENST00000381683RAF1chr312653449-EIF3Lchr2238282772+0.1231462960.8768537
ENST00000442415ENST00000406934RAF1chr312653449-EIF3Lchr2238282772+0.1488660.851134
ENST00000542177ENST00000412331RAF1chr312660013-EIF3Lchr2238282771+0.0425645260.9574354
ENST00000542177ENST00000381683RAF1chr312660013-EIF3Lchr2238282771+0.049131190.9508688
ENST00000542177ENST00000406934RAF1chr312660013-EIF3Lchr2238282771+0.057606380.94239366

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Fusion Genomic Features for RAF1-EIF3L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RAF1chr312660013-EIF3Lchr2238282771+7.69E-080.9999999
RAF1chr312653448-EIF3Lchr2238282771+2.68E-081
RAF1chr312660013-EIF3Lchr2238282771+7.69E-080.9999999
RAF1chr312653448-EIF3Lchr2238282771+2.68E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RAF1-EIF3L


check button Go to

FGviewer for the breakpoints of chr3:12653449-chr22:38282772

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EIF3L

Q9Y262

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03011, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). {ECO:0000269|PubMed:18056426}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAF1chr3:12653449chr22:38282772ENST00000251849-317349_609106.66666666666667649.0DomainProtein kinase
HgeneRAF1chr3:12653449chr22:38282772ENST00000251849-31756_131106.66666666666667649.0DomainRBD
HgeneRAF1chr3:12653449chr22:38282772ENST00000442415-318349_609106.66666666666667669.0DomainProtein kinase
HgeneRAF1chr3:12653449chr22:38282772ENST00000442415-31856_131106.66666666666667669.0DomainRBD
HgeneRAF1chr3:12660013chr22:38282771ENST00000251849-217349_60969.0649.0DomainProtein kinase
HgeneRAF1chr3:12660013chr22:38282771ENST00000251849-21756_13169.0649.0DomainRBD
HgeneRAF1chr3:12660013chr22:38282771ENST00000442415-218349_60969.0669.0DomainProtein kinase
HgeneRAF1chr3:12660013chr22:38282771ENST00000442415-21856_13169.0669.0DomainRBD
HgeneRAF1chr3:12653449chr22:38282772ENST00000251849-317355_363106.66666666666667649.0Nucleotide bindingATP
HgeneRAF1chr3:12653449chr22:38282772ENST00000442415-318355_363106.66666666666667669.0Nucleotide bindingATP
HgeneRAF1chr3:12660013chr22:38282771ENST00000251849-217355_36369.0649.0Nucleotide bindingATP
HgeneRAF1chr3:12660013chr22:38282771ENST00000442415-218355_36369.0669.0Nucleotide bindingATP
HgeneRAF1chr3:12653449chr22:38282772ENST00000251849-317138_184106.66666666666667649.0Zinc fingerPhorbol-ester/DAG-type
HgeneRAF1chr3:12653449chr22:38282772ENST00000442415-318138_184106.66666666666667669.0Zinc fingerPhorbol-ester/DAG-type
HgeneRAF1chr3:12660013chr22:38282771ENST00000251849-217138_18469.0649.0Zinc fingerPhorbol-ester/DAG-type
HgeneRAF1chr3:12660013chr22:38282771ENST00000442415-218138_18469.0669.0Zinc fingerPhorbol-ester/DAG-type
TgeneEIF3Lchr3:12653449chr22:38282772ENST00000381683811331_537477.0517.0DomainPCI
TgeneEIF3Lchr3:12653449chr22:38282772ENST000004123311013331_537525.0565.0DomainPCI
TgeneEIF3Lchr3:12660013chr22:38282771ENST00000381683811331_537477.0517.0DomainPCI
TgeneEIF3Lchr3:12660013chr22:38282771ENST000004123311013331_537525.0565.0DomainPCI


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Fusion Gene Sequence for RAF1-EIF3L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000251849_ENST00000412331_TCGA-G8-6325-01A_RAF1_chr3_12653449_-_EIF3L_chr22_38282772_length(transcript)=1823nt_BP=760nt
AGTCGACTGCCAGTAGGGCTCGCGCAGAATCGGAGAGCCGGTGGCGTCGCAGGTCGGGAGGACGAGCACCGAGTCGAGGGCTCGCTCGTC
TGGGCCGCCCGAGAGTCTTAATCGCGGGCGCTTGGGCCGCCATCTTAGATGGCGGGAGTAAGAGGAAAACGATTGTGAGGCGGGAACGGC
TTTCTGCTGCCTTTTTTGGGCCCCGAAAAGGGTCAGCTGGCCGGGCTTTGGGGCGCGTGCCCTGAGGCGCGGAGCGCGTTTGCTACGATG
CGGGGGCTGCTCGGGGCTCCGTCCCCTGGGCTGGGGACGCGCCGAATGTGACCGCCTCCCGCTCCCTCACCCGCCGCGGGGAGGAGGAGC
GGGCGAGAAGCTGCCGCCGAACGACAGGACGTTGGGGCGGCCTGGCTCCCTCAGGTTTAAGAATTGTTTAAGCTGCATCAATGGAGCACA
TACAGGGAGCTTGGAAGACGATCAGCAATGGTTTTGGATTCAAAGATGCCGTGTTTGATGGCTCCAGCTGCATCTCTCCTACAATAGTTC
AGCAGTTTGGCTATCAGCGCCGGGCATCAGATGATGGCAAACTCACAGATCCTTCTAAGACAAGCAACACTATCCGTGTTTTCTTGCCGA
ACAAGCAAAGAACAGTGGTCAATGTGCGAAATGGAATGAGCTTGCATGACTGCCTTATGAAAGCACTCAAGGTGAGGGGCCTGCAACCAG
AGTGCTGTGCAGTGTTCAGACTTCTCCACGAACACAAAGGGACATGATCCACATCGCGGACACCAAGGTCGCCAGGCGTTATGGGGATTT
CTTCATCCGTCAGATCCACAAATTTGAGGAGCTTAATCGAACCCTGAAGAAGATGGGACAGAGACCTTGATGATATTCACACACATTCAG
GAACCTGTTTTGATGTATTATAGGCAGGAAGTGTTTTTGCTACCGTGAAACCTTTACCTAGATCAGCCATCAGCCTGTCAACTCAGTTAA
CAAGTTAAGGACCGAAGTGTTTCAAGTGGATCTCAGTAAAGGATCTTTGGAGCCAGATTTGTCGTCTCATTATTGTAGGAGAGAATTTGT
GGGTTGTGGCAGTAATACATTTCCCATGTGTCCTGATGCTTTCAGGATACATCAGTTGTTAGTGTTTAAATTGAGTTATTTTTATTTTGT
GCTTTTGAGATGGAGTCTCACTCTGTCTCCCAGGCTGGAGTGCAGTAGCGTGATCTCAGTTCGTTGCATCCTCCGCTGCCCAGGTTCAAG
CAGTTCTGCCTCAGCCTTCCAAGTAGCTGGGATTACAGGCGTGTGCCACCACACTCAGCTAATTTTTGTATTCTCAGTAGAGATGGGTTT
TACCATGTTGGCCAGGCTGGTCTCGAACTCCTGGCCTCAAGTGATTCGCCTGCCTTGGCCTCCCAAAATGTGCTAGGATTACAGGCATGA
GCCACCACGCCCCGCCTAAATTCAAAATCTTTTTGTTTTTTTTTAGACGGAGTCTCACTCTGTCGCCCAGGTTGGAGTGTACTGGCGCGA
TCTCGGCTCACTGCAAGCTCCACCTCCCAGGTTCCTGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACCCGCCACC
ATGCCCGGCCAATTTTTTGTATTTTTTAGTAGAGATGGGGTTTCACCGTGTTAGCCAGGATGGTCTCAGATTTCCTGACCTCGTGATCTG
CCCATCTCTGCCTCCTAAAGTACTGGGATTACAGGCGTGAGCCACCGTGCCCAGCCCTAAATTGAATTCTTAAATCCCTCTTGTTCATAA

>In-frame_ENST00000251849_ENST00000412331_TCGA-G8-6325-01A_RAF1_chr3_12653449_-_EIF3L_chr22_38282772_length(amino acids)=129AA_start in transcript=1036_stop in transcript=1425
MEPDLSSHYCRREFVGCGSNTFPMCPDAFRIHQLLVFKLSYFYFVLLRWSLTLSPRLECSSVISVRCILRCPGSSSSASAFQVAGITGVC

--------------------------------------------------------------
>In-frame_ENST00000251849_ENST00000381683_TCGA-G8-6325-01A_RAF1_chr3_12653449_-_EIF3L_chr22_38282772_length(transcript)=895nt_BP=760nt
AGTCGACTGCCAGTAGGGCTCGCGCAGAATCGGAGAGCCGGTGGCGTCGCAGGTCGGGAGGACGAGCACCGAGTCGAGGGCTCGCTCGTC
TGGGCCGCCCGAGAGTCTTAATCGCGGGCGCTTGGGCCGCCATCTTAGATGGCGGGAGTAAGAGGAAAACGATTGTGAGGCGGGAACGGC
TTTCTGCTGCCTTTTTTGGGCCCCGAAAAGGGTCAGCTGGCCGGGCTTTGGGGCGCGTGCCCTGAGGCGCGGAGCGCGTTTGCTACGATG
CGGGGGCTGCTCGGGGCTCCGTCCCCTGGGCTGGGGACGCGCCGAATGTGACCGCCTCCCGCTCCCTCACCCGCCGCGGGGAGGAGGAGC
GGGCGAGAAGCTGCCGCCGAACGACAGGACGTTGGGGCGGCCTGGCTCCCTCAGGTTTAAGAATTGTTTAAGCTGCATCAATGGAGCACA
TACAGGGAGCTTGGAAGACGATCAGCAATGGTTTTGGATTCAAAGATGCCGTGTTTGATGGCTCCAGCTGCATCTCTCCTACAATAGTTC
AGCAGTTTGGCTATCAGCGCCGGGCATCAGATGATGGCAAACTCACAGATCCTTCTAAGACAAGCAACACTATCCGTGTTTTCTTGCCGA
ACAAGCAAAGAACAGTGGTCAATGTGCGAAATGGAATGAGCTTGCATGACTGCCTTATGAAAGCACTCAAGGTGAGGGGCCTGCAACCAG
AGTGCTGTGCAGTGTTCAGACTTCTCCACGAACACAAAGGGACATGATCCACATCGCGGACACCAAGGTCGCCAGGCGTTATGGGGATTT

>In-frame_ENST00000251849_ENST00000381683_TCGA-G8-6325-01A_RAF1_chr3_12653449_-_EIF3L_chr22_38282772_length(amino acids)=108AA_start in transcript=440_stop in transcript=766
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRG

--------------------------------------------------------------
>In-frame_ENST00000251849_ENST00000406934_TCGA-G8-6325-01A_RAF1_chr3_12653449_-_EIF3L_chr22_38282772_length(transcript)=1046nt_BP=760nt
AGTCGACTGCCAGTAGGGCTCGCGCAGAATCGGAGAGCCGGTGGCGTCGCAGGTCGGGAGGACGAGCACCGAGTCGAGGGCTCGCTCGTC
TGGGCCGCCCGAGAGTCTTAATCGCGGGCGCTTGGGCCGCCATCTTAGATGGCGGGAGTAAGAGGAAAACGATTGTGAGGCGGGAACGGC
TTTCTGCTGCCTTTTTTGGGCCCCGAAAAGGGTCAGCTGGCCGGGCTTTGGGGCGCGTGCCCTGAGGCGCGGAGCGCGTTTGCTACGATG
CGGGGGCTGCTCGGGGCTCCGTCCCCTGGGCTGGGGACGCGCCGAATGTGACCGCCTCCCGCTCCCTCACCCGCCGCGGGGAGGAGGAGC
GGGCGAGAAGCTGCCGCCGAACGACAGGACGTTGGGGCGGCCTGGCTCCCTCAGGTTTAAGAATTGTTTAAGCTGCATCAATGGAGCACA
TACAGGGAGCTTGGAAGACGATCAGCAATGGTTTTGGATTCAAAGATGCCGTGTTTGATGGCTCCAGCTGCATCTCTCCTACAATAGTTC
AGCAGTTTGGCTATCAGCGCCGGGCATCAGATGATGGCAAACTCACAGATCCTTCTAAGACAAGCAACACTATCCGTGTTTTCTTGCCGA
ACAAGCAAAGAACAGTGGTCAATGTGCGAAATGGAATGAGCTTGCATGACTGCCTTATGAAAGCACTCAAGGTGAGGGGCCTGCAACCAG
AGTGCTGTGCAGTGTTCAGACTTCTCCACGAACACAAAGGGACATGATCCACATCGCGGACACCAAGGTCGCCAGGCGTTATGGGGATTT
CTTCATCCGTCAGATCCACAAATTTGAGGAGCTTAATCGAACCCTGAAGAAGATGGGACAGAGACCTTGATGATATTCACACACATTCAG
GAACCTGTTTTGATGTATTATAGGCAGGAAGTGTTTTTGCTACCGTGAAACCTTTACCTAGATCAGCCATCAGCCTGTCAACTCAGTTAA

>In-frame_ENST00000251849_ENST00000406934_TCGA-G8-6325-01A_RAF1_chr3_12653449_-_EIF3L_chr22_38282772_length(amino acids)=108AA_start in transcript=440_stop in transcript=766
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRG

--------------------------------------------------------------
>In-frame_ENST00000442415_ENST00000412331_TCGA-G8-6325-01A_RAF1_chr3_12653449_-_EIF3L_chr22_38282772_length(transcript)=1745nt_BP=682nt
GGCTCGCTCGTCTGGGCCGCCCGAGAGTCTTAATCGCGGGCGCTTGGGCCGCCATCTTAGATGGCGGGAGTAAGAGGAAAACGATTGTGA
GGCGGGAACGGCTTTCTGCTGCCTTTTTTGGGCCCCGAAAAGGGTCAGCTGGCCGGGCTTTGGGGCGCGTGCCCTGAGGCGCGGAGCGCG
TTTGCTACGATGCGGGGGCTGCTCGGGGCTCCGTCCCCTGGGCTGGGGACGCGCCGAATGTGACCGCCTCCCGCTCCCTCACCCGCCGCG
GGGAGGAGGAGCGGGCGAGAAGCTGCCGCCGAACGACAGGACGTTGGGGCGGCCTGGCTCCCTCAGGTTTAAGAATTGTTTAAGCTGCAT
CAATGGAGCACATACAGGGAGCTTGGAAGACGATCAGCAATGGTTTTGGATTCAAAGATGCCGTGTTTGATGGCTCCAGCTGCATCTCTC
CTACAATAGTTCAGCAGTTTGGCTATCAGCGCCGGGCATCAGATGATGGCAAACTCACAGATCCTTCTAAGACAAGCAACACTATCCGTG
TTTTCTTGCCGAACAAGCAAAGAACAGTGGTCAATGTGCGAAATGGAATGAGCTTGCATGACTGCCTTATGAAAGCACTCAAGGTGAGGG
GCCTGCAACCAGAGTGCTGTGCAGTGTTCAGACTTCTCCACGAACACAAAGGGACATGATCCACATCGCGGACACCAAGGTCGCCAGGCG
TTATGGGGATTTCTTCATCCGTCAGATCCACAAATTTGAGGAGCTTAATCGAACCCTGAAGAAGATGGGACAGAGACCTTGATGATATTC
ACACACATTCAGGAACCTGTTTTGATGTATTATAGGCAGGAAGTGTTTTTGCTACCGTGAAACCTTTACCTAGATCAGCCATCAGCCTGT
CAACTCAGTTAACAAGTTAAGGACCGAAGTGTTTCAAGTGGATCTCAGTAAAGGATCTTTGGAGCCAGATTTGTCGTCTCATTATTGTAG
GAGAGAATTTGTGGGTTGTGGCAGTAATACATTTCCCATGTGTCCTGATGCTTTCAGGATACATCAGTTGTTAGTGTTTAAATTGAGTTA
TTTTTATTTTGTGCTTTTGAGATGGAGTCTCACTCTGTCTCCCAGGCTGGAGTGCAGTAGCGTGATCTCAGTTCGTTGCATCCTCCGCTG
CCCAGGTTCAAGCAGTTCTGCCTCAGCCTTCCAAGTAGCTGGGATTACAGGCGTGTGCCACCACACTCAGCTAATTTTTGTATTCTCAGT
AGAGATGGGTTTTACCATGTTGGCCAGGCTGGTCTCGAACTCCTGGCCTCAAGTGATTCGCCTGCCTTGGCCTCCCAAAATGTGCTAGGA
TTACAGGCATGAGCCACCACGCCCCGCCTAAATTCAAAATCTTTTTGTTTTTTTTTAGACGGAGTCTCACTCTGTCGCCCAGGTTGGAGT
GTACTGGCGCGATCTCGGCTCACTGCAAGCTCCACCTCCCAGGTTCCTGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAG
GCACCCGCCACCATGCCCGGCCAATTTTTTGTATTTTTTAGTAGAGATGGGGTTTCACCGTGTTAGCCAGGATGGTCTCAGATTTCCTGA
CCTCGTGATCTGCCCATCTCTGCCTCCTAAAGTACTGGGATTACAGGCGTGAGCCACCGTGCCCAGCCCTAAATTGAATTCTTAAATCCC

>In-frame_ENST00000442415_ENST00000412331_TCGA-G8-6325-01A_RAF1_chr3_12653449_-_EIF3L_chr22_38282772_length(amino acids)=129AA_start in transcript=958_stop in transcript=1347
MEPDLSSHYCRREFVGCGSNTFPMCPDAFRIHQLLVFKLSYFYFVLLRWSLTLSPRLECSSVISVRCILRCPGSSSSASAFQVAGITGVC

--------------------------------------------------------------
>In-frame_ENST00000442415_ENST00000381683_TCGA-G8-6325-01A_RAF1_chr3_12653449_-_EIF3L_chr22_38282772_length(transcript)=817nt_BP=682nt
GGCTCGCTCGTCTGGGCCGCCCGAGAGTCTTAATCGCGGGCGCTTGGGCCGCCATCTTAGATGGCGGGAGTAAGAGGAAAACGATTGTGA
GGCGGGAACGGCTTTCTGCTGCCTTTTTTGGGCCCCGAAAAGGGTCAGCTGGCCGGGCTTTGGGGCGCGTGCCCTGAGGCGCGGAGCGCG
TTTGCTACGATGCGGGGGCTGCTCGGGGCTCCGTCCCCTGGGCTGGGGACGCGCCGAATGTGACCGCCTCCCGCTCCCTCACCCGCCGCG
GGGAGGAGGAGCGGGCGAGAAGCTGCCGCCGAACGACAGGACGTTGGGGCGGCCTGGCTCCCTCAGGTTTAAGAATTGTTTAAGCTGCAT
CAATGGAGCACATACAGGGAGCTTGGAAGACGATCAGCAATGGTTTTGGATTCAAAGATGCCGTGTTTGATGGCTCCAGCTGCATCTCTC
CTACAATAGTTCAGCAGTTTGGCTATCAGCGCCGGGCATCAGATGATGGCAAACTCACAGATCCTTCTAAGACAAGCAACACTATCCGTG
TTTTCTTGCCGAACAAGCAAAGAACAGTGGTCAATGTGCGAAATGGAATGAGCTTGCATGACTGCCTTATGAAAGCACTCAAGGTGAGGG
GCCTGCAACCAGAGTGCTGTGCAGTGTTCAGACTTCTCCACGAACACAAAGGGACATGATCCACATCGCGGACACCAAGGTCGCCAGGCG
TTATGGGGATTTCTTCATCCGTCAGATCCACAAATTTGAGGAGCTTAATCGAACCCTGAAGAAGATGGGACAGAGACCTTGATGATATTC

>In-frame_ENST00000442415_ENST00000381683_TCGA-G8-6325-01A_RAF1_chr3_12653449_-_EIF3L_chr22_38282772_length(amino acids)=108AA_start in transcript=362_stop in transcript=688
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRG

--------------------------------------------------------------
>In-frame_ENST00000442415_ENST00000406934_TCGA-G8-6325-01A_RAF1_chr3_12653449_-_EIF3L_chr22_38282772_length(transcript)=968nt_BP=682nt
GGCTCGCTCGTCTGGGCCGCCCGAGAGTCTTAATCGCGGGCGCTTGGGCCGCCATCTTAGATGGCGGGAGTAAGAGGAAAACGATTGTGA
GGCGGGAACGGCTTTCTGCTGCCTTTTTTGGGCCCCGAAAAGGGTCAGCTGGCCGGGCTTTGGGGCGCGTGCCCTGAGGCGCGGAGCGCG
TTTGCTACGATGCGGGGGCTGCTCGGGGCTCCGTCCCCTGGGCTGGGGACGCGCCGAATGTGACCGCCTCCCGCTCCCTCACCCGCCGCG
GGGAGGAGGAGCGGGCGAGAAGCTGCCGCCGAACGACAGGACGTTGGGGCGGCCTGGCTCCCTCAGGTTTAAGAATTGTTTAAGCTGCAT
CAATGGAGCACATACAGGGAGCTTGGAAGACGATCAGCAATGGTTTTGGATTCAAAGATGCCGTGTTTGATGGCTCCAGCTGCATCTCTC
CTACAATAGTTCAGCAGTTTGGCTATCAGCGCCGGGCATCAGATGATGGCAAACTCACAGATCCTTCTAAGACAAGCAACACTATCCGTG
TTTTCTTGCCGAACAAGCAAAGAACAGTGGTCAATGTGCGAAATGGAATGAGCTTGCATGACTGCCTTATGAAAGCACTCAAGGTGAGGG
GCCTGCAACCAGAGTGCTGTGCAGTGTTCAGACTTCTCCACGAACACAAAGGGACATGATCCACATCGCGGACACCAAGGTCGCCAGGCG
TTATGGGGATTTCTTCATCCGTCAGATCCACAAATTTGAGGAGCTTAATCGAACCCTGAAGAAGATGGGACAGAGACCTTGATGATATTC
ACACACATTCAGGAACCTGTTTTGATGTATTATAGGCAGGAAGTGTTTTTGCTACCGTGAAACCTTTACCTAGATCAGCCATCAGCCTGT

>In-frame_ENST00000442415_ENST00000406934_TCGA-G8-6325-01A_RAF1_chr3_12653449_-_EIF3L_chr22_38282772_length(amino acids)=108AA_start in transcript=362_stop in transcript=688
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRG

--------------------------------------------------------------
>In-frame_ENST00000542177_ENST00000412331_TCGA-G8-6325_RAF1_chr3_12660013_-_EIF3L_chr22_38282771_length(transcript)=1601nt_BP=538nt
AATCGCGGGCGCTTGGGCCGCCATCTTAGATGGCGGGAGTAAGAGGAAAACGATTGTGAGGCGGGAACGGCTTTCTGCTGCCTTTTTTGG
GCCCCGAAAAGGGTCAGCTGGCCGGGCTTTGGGGCGCGTGCCCTGAGGCGCGGAGCGCGTTTGCTACGATGCGGGGGCTGCTCGGGGCTC
CGTCCCCTGGGCTGGGGACGCGCCGAATGTGACCGCCTCCCGCTCCCTCACCCGCCGCGGGGAGGAGGAGCGGGCGAGAAGCTGCCGCCG
AACGACAGGACGTTGGGGCGGCCTGGCTCCCTCAGGTTTAAGAATTGTTTAAGCTGCATCAATGGAGCACATACAGGGAGCTTGGAAGAC
GATCAGCAATGGTTTTGGATTCAAAGATGCCGTGTTTGATGGCTCCAGCTGCATCTCTCCTACAATAGTTCAGCAGTTTGGCTATCAGCG
CCGGGCATCAGATGATGGCAAACTCACAGATCCTTCTAAGACAAGCAACACTATCCGTGTTTTCTTGCCGAACAAGCAAAGAACAGTGGA
CATGATCCACATCGCGGACACCAAGGTCGCCAGGCGTTATGGGGATTTCTTCATCCGTCAGATCCACAAATTTGAGGAGCTTAATCGAAC
CCTGAAGAAGATGGGACAGAGACCTTGATGATATTCACACACATTCAGGAACCTGTTTTGATGTATTATAGGCAGGAAGTGTTTTTGCTA
CCGTGAAACCTTTACCTAGATCAGCCATCAGCCTGTCAACTCAGTTAACAAGTTAAGGACCGAAGTGTTTCAAGTGGATCTCAGTAAAGG
ATCTTTGGAGCCAGATTTGTCGTCTCATTATTGTAGGAGAGAATTTGTGGGTTGTGGCAGTAATACATTTCCCATGTGTCCTGATGCTTT
CAGGATACATCAGTTGTTAGTGTTTAAATTGAGTTATTTTTATTTTGTGCTTTTGAGATGGAGTCTCACTCTGTCTCCCAGGCTGGAGTG
CAGTAGCGTGATCTCAGTTCGTTGCATCCTCCGCTGCCCAGGTTCAAGCAGTTCTGCCTCAGCCTTCCAAGTAGCTGGGATTACAGGCGT
GTGCCACCACACTCAGCTAATTTTTGTATTCTCAGTAGAGATGGGTTTTACCATGTTGGCCAGGCTGGTCTCGAACTCCTGGCCTCAAGT
GATTCGCCTGCCTTGGCCTCCCAAAATGTGCTAGGATTACAGGCATGAGCCACCACGCCCCGCCTAAATTCAAAATCTTTTTGTTTTTTT
TTAGACGGAGTCTCACTCTGTCGCCCAGGTTGGAGTGTACTGGCGCGATCTCGGCTCACTGCAAGCTCCACCTCCCAGGTTCCTGCCATT
CTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACCCGCCACCATGCCCGGCCAATTTTTTGTATTTTTTAGTAGAGATGGGGTT
TCACCGTGTTAGCCAGGATGGTCTCAGATTTCCTGACCTCGTGATCTGCCCATCTCTGCCTCCTAAAGTACTGGGATTACAGGCGTGAGC

>In-frame_ENST00000542177_ENST00000412331_TCGA-G8-6325_RAF1_chr3_12660013_-_EIF3L_chr22_38282771_length(amino acids)=129AA_start in transcript=814_stop in transcript=1203
MEPDLSSHYCRREFVGCGSNTFPMCPDAFRIHQLLVFKLSYFYFVLLRWSLTLSPRLECSSVISVRCILRCPGSSSSASAFQVAGITGVC

--------------------------------------------------------------
>In-frame_ENST00000542177_ENST00000381683_TCGA-G8-6325_RAF1_chr3_12660013_-_EIF3L_chr22_38282771_length(transcript)=673nt_BP=538nt
AATCGCGGGCGCTTGGGCCGCCATCTTAGATGGCGGGAGTAAGAGGAAAACGATTGTGAGGCGGGAACGGCTTTCTGCTGCCTTTTTTGG
GCCCCGAAAAGGGTCAGCTGGCCGGGCTTTGGGGCGCGTGCCCTGAGGCGCGGAGCGCGTTTGCTACGATGCGGGGGCTGCTCGGGGCTC
CGTCCCCTGGGCTGGGGACGCGCCGAATGTGACCGCCTCCCGCTCCCTCACCCGCCGCGGGGAGGAGGAGCGGGCGAGAAGCTGCCGCCG
AACGACAGGACGTTGGGGCGGCCTGGCTCCCTCAGGTTTAAGAATTGTTTAAGCTGCATCAATGGAGCACATACAGGGAGCTTGGAAGAC
GATCAGCAATGGTTTTGGATTCAAAGATGCCGTGTTTGATGGCTCCAGCTGCATCTCTCCTACAATAGTTCAGCAGTTTGGCTATCAGCG
CCGGGCATCAGATGATGGCAAACTCACAGATCCTTCTAAGACAAGCAACACTATCCGTGTTTTCTTGCCGAACAAGCAAAGAACAGTGGA
CATGATCCACATCGCGGACACCAAGGTCGCCAGGCGTTATGGGGATTTCTTCATCCGTCAGATCCACAAATTTGAGGAGCTTAATCGAAC

>In-frame_ENST00000542177_ENST00000381683_TCGA-G8-6325_RAF1_chr3_12660013_-_EIF3L_chr22_38282771_length(amino acids)=108AA_start in transcript=331_stop in transcript=657
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVDMIHIADTKVARRYGDFFIRQ

--------------------------------------------------------------
>In-frame_ENST00000542177_ENST00000406934_TCGA-G8-6325_RAF1_chr3_12660013_-_EIF3L_chr22_38282771_length(transcript)=824nt_BP=538nt
AATCGCGGGCGCTTGGGCCGCCATCTTAGATGGCGGGAGTAAGAGGAAAACGATTGTGAGGCGGGAACGGCTTTCTGCTGCCTTTTTTGG
GCCCCGAAAAGGGTCAGCTGGCCGGGCTTTGGGGCGCGTGCCCTGAGGCGCGGAGCGCGTTTGCTACGATGCGGGGGCTGCTCGGGGCTC
CGTCCCCTGGGCTGGGGACGCGCCGAATGTGACCGCCTCCCGCTCCCTCACCCGCCGCGGGGAGGAGGAGCGGGCGAGAAGCTGCCGCCG
AACGACAGGACGTTGGGGCGGCCTGGCTCCCTCAGGTTTAAGAATTGTTTAAGCTGCATCAATGGAGCACATACAGGGAGCTTGGAAGAC
GATCAGCAATGGTTTTGGATTCAAAGATGCCGTGTTTGATGGCTCCAGCTGCATCTCTCCTACAATAGTTCAGCAGTTTGGCTATCAGCG
CCGGGCATCAGATGATGGCAAACTCACAGATCCTTCTAAGACAAGCAACACTATCCGTGTTTTCTTGCCGAACAAGCAAAGAACAGTGGA
CATGATCCACATCGCGGACACCAAGGTCGCCAGGCGTTATGGGGATTTCTTCATCCGTCAGATCCACAAATTTGAGGAGCTTAATCGAAC
CCTGAAGAAGATGGGACAGAGACCTTGATGATATTCACACACATTCAGGAACCTGTTTTGATGTATTATAGGCAGGAAGTGTTTTTGCTA
CCGTGAAACCTTTACCTAGATCAGCCATCAGCCTGTCAACTCAGTTAACAAGTTAAGGACCGAAGTGTTTCAAGTGGATCTCAGTAAAGG

>In-frame_ENST00000542177_ENST00000406934_TCGA-G8-6325_RAF1_chr3_12660013_-_EIF3L_chr22_38282771_length(amino acids)=108AA_start in transcript=331_stop in transcript=657
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVDMIHIADTKVARRYGDFFIRQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RAF1-EIF3L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRAF1chr3:12653449chr22:38282772ENST00000251849-317331_349106.66666666666667649.0PEBP1/RKIP
HgeneRAF1chr3:12653449chr22:38282772ENST00000442415-318331_349106.66666666666667669.0PEBP1/RKIP
HgeneRAF1chr3:12660013chr22:38282771ENST00000251849-217331_34969.0649.0PEBP1/RKIP
HgeneRAF1chr3:12660013chr22:38282771ENST00000442415-218331_34969.0669.0PEBP1/RKIP


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RAF1-EIF3L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RAF1-EIF3L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRAF1C0028326Noonan Syndrome10CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneRAF1C0175704LEOPARD Syndrome7CLINGEN;CTD_human;GENOMICS_ENGLAND
HgeneRAF1C1969057Noonan Syndrome 54CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneRAF1C1969056LEOPARD SYNDROME 23CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneRAF1C0007194Hypertrophic Cardiomyopathy2CTD_human
HgeneRAF1C0041409Turner Syndrome, Male2CTD_human
HgeneRAF1C1519086Pilomyxoid astrocytoma2ORPHANET
HgeneRAF1C1527404Female Pseudo-Turner Syndrome2CTD_human
HgeneRAF1C4551472Hypertrophic obstructive cardiomyopathy2CTD_human
HgeneRAF1C4551602Noonan Syndrome 12CTD_human
HgeneRAF1C0006142Malignant neoplasm of breast1CTD_human
HgeneRAF1C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneRAF1C0007193Cardiomyopathy, Dilated1CTD_human
HgeneRAF1C0017638Glioma1CTD_human
HgeneRAF1C0020429Hyperalgesia1CTD_human
HgeneRAF1C0022665Kidney Neoplasm1CTD_human
HgeneRAF1C0023903Liver neoplasms1CTD_human
HgeneRAF1C0024121Lung Neoplasms1CTD_human
HgeneRAF1C0242379Malignant neoplasm of lung1CTD_human
HgeneRAF1C0259783mixed gliomas1CTD_human
HgeneRAF1C0340427Familial dilated cardiomyopathy1ORPHANET
HgeneRAF1C0345904Malignant neoplasm of liver1CTD_human
HgeneRAF1C0345967Malignant mesothelioma1CTD_human
HgeneRAF1C0458247Allodynia1CTD_human
HgeneRAF1C0555198Malignant Glioma1CTD_human
HgeneRAF1C0587248Costello syndrome (disorder)1CLINGEN
HgeneRAF1C0678222Breast Carcinoma1CTD_human
HgeneRAF1C0740457Malignant neoplasm of kidney1CTD_human
HgeneRAF1C0751211Hyperalgesia, Primary1CTD_human
HgeneRAF1C0751212Hyperalgesia, Secondary1CTD_human
HgeneRAF1C0751213Tactile Allodynia1CTD_human
HgeneRAF1C0751214Hyperalgesia, Thermal1CTD_human
HgeneRAF1C1257931Mammary Neoplasms, Human1CTD_human
HgeneRAF1C1275081Cardio-facio-cutaneous syndrome1CLINGEN
HgeneRAF1C1449563Cardiomyopathy, Familial Idiopathic1CTD_human
HgeneRAF1C1458155Mammary Neoplasms1CTD_human
HgeneRAF1C2936719Mechanical Allodynia1CTD_human
HgeneRAF1C4014656CARDIOMYOPATHY, DILATED, 1NN1CTD_human;UNIPROT
HgeneRAF1C4551484Leopard Syndrome 11CTD_human;GENOMICS_ENGLAND
HgeneRAF1C4704874Mammary Carcinoma, Human1CTD_human
HgeneRAF1C4721610Carcinoma, Ovarian Epithelial1CTD_human