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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:RANBP10-KARS (FusionGDB2 ID:71587) |
Fusion Gene Summary for RANBP10-KARS |
Fusion gene summary |
Fusion gene information | Fusion gene name: RANBP10-KARS | Fusion gene ID: 71587 | Hgene | Tgene | Gene symbol | RANBP10 | KARS | Gene ID | 57610 | 3735 |
Gene name | RAN binding protein 10 | lysyl-tRNA synthetase 1 | |
Synonyms | - | CMTRIB|DFNB89|KARS|KARS2|KRS | |
Cytomap | 16q22.1 | 16q23.1 | |
Type of gene | protein-coding | protein-coding | |
Description | ran-binding protein 10 | lysine--tRNA ligaselysRSlysine tRNA ligase | |
Modification date | 20200313 | 20200318 | |
UniProtAcc | . | Q15046 | |
Ensembl transtripts involved in fusion gene | ENST00000317506, ENST00000448631, ENST00000536251, ENST00000411657, ENST00000602677, ENST00000425512, ENST00000602887, | ENST00000319410, ENST00000302445, ENST00000568378, | |
Fusion gene scores | * DoF score | 11 X 9 X 7=693 | 7 X 7 X 4=196 |
# samples | 13 | 9 | |
** MAII score | log2(13/693*10)=-2.41434372910876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/196*10)=-1.12285674778553 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RANBP10 [Title/Abstract] AND KARS [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | RANBP10(67839331)-KARS(75675621), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | RANBP10-KARS seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. RANBP10-KARS seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | KARS | GO:0000187 | activation of MAPK activity | 15851690 |
Tgene | KARS | GO:0002741 | positive regulation of cytokine secretion involved in immune response | 15851690 |
Tgene | KARS | GO:0006430 | lysyl-tRNA aminoacylation | 9278442|10952987|23159739 |
Tgene | KARS | GO:0008285 | negative regulation of cell proliferation | 15851690 |
Tgene | KARS | GO:0010759 | positive regulation of macrophage chemotaxis | 15851690 |
Tgene | KARS | GO:0015966 | diadenosine tetraphosphate biosynthetic process | 23159739 |
Tgene | KARS | GO:0033209 | tumor necrosis factor-mediated signaling pathway | 15851690 |
Tgene | KARS | GO:0043032 | positive regulation of macrophage activation | 15851690 |
Tgene | KARS | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 15851690 |
Tgene | KARS | GO:1900017 | positive regulation of cytokine production involved in inflammatory response | 15851690 |
Tgene | KARS | GO:1900745 | positive regulation of p38MAPK cascade | 15851690 |
Tgene | KARS | GO:1905050 | positive regulation of metallopeptidase activity | 15851690 |
Fusion gene breakpoints across RANBP10 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across KARS (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | OV | TCGA-61-2008-02A | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - |
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Fusion Gene ORF analysis for RANBP10-KARS |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000317506 | ENST00000319410 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - |
In-frame | ENST00000317506 | ENST00000302445 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - |
5CDS-intron | ENST00000317506 | ENST00000568378 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - |
In-frame | ENST00000448631 | ENST00000319410 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - |
In-frame | ENST00000448631 | ENST00000302445 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - |
5CDS-intron | ENST00000448631 | ENST00000568378 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - |
5UTR-3CDS | ENST00000536251 | ENST00000319410 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - |
5UTR-3CDS | ENST00000536251 | ENST00000302445 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - |
5UTR-intron | ENST00000536251 | ENST00000568378 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - |
intron-3CDS | ENST00000411657 | ENST00000319410 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - |
intron-3CDS | ENST00000411657 | ENST00000302445 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - |
intron-intron | ENST00000411657 | ENST00000568378 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - |
In-frame | ENST00000602677 | ENST00000319410 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - |
In-frame | ENST00000602677 | ENST00000302445 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - |
5CDS-intron | ENST00000602677 | ENST00000568378 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - |
Frame-shift | ENST00000425512 | ENST00000319410 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - |
Frame-shift | ENST00000425512 | ENST00000302445 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - |
5CDS-intron | ENST00000425512 | ENST00000568378 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - |
5UTR-3CDS | ENST00000602887 | ENST00000319410 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - |
5UTR-3CDS | ENST00000602887 | ENST00000302445 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - |
5UTR-intron | ENST00000602887 | ENST00000568378 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000317506 | RANBP10 | chr16 | 67839331 | - | ENST00000319410 | KARS | chr16 | 75675621 | - | 2366 | 463 | 50 | 2194 | 714 |
ENST00000317506 | RANBP10 | chr16 | 67839331 | - | ENST00000302445 | KARS | chr16 | 75675621 | - | 2366 | 463 | 50 | 2194 | 714 |
ENST00000448631 | RANBP10 | chr16 | 67839331 | - | ENST00000319410 | KARS | chr16 | 75675621 | - | 2274 | 371 | 24 | 2102 | 692 |
ENST00000448631 | RANBP10 | chr16 | 67839331 | - | ENST00000302445 | KARS | chr16 | 75675621 | - | 2274 | 371 | 24 | 2102 | 692 |
ENST00000602677 | RANBP10 | chr16 | 67839331 | - | ENST00000319410 | KARS | chr16 | 75675621 | - | 2274 | 371 | 24 | 2102 | 692 |
ENST00000602677 | RANBP10 | chr16 | 67839331 | - | ENST00000302445 | KARS | chr16 | 75675621 | - | 2274 | 371 | 24 | 2102 | 692 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000317506 | ENST00000319410 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - | 0.001541869 | 0.99845815 |
ENST00000317506 | ENST00000302445 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - | 0.001541869 | 0.99845815 |
ENST00000448631 | ENST00000319410 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - | 0.001533089 | 0.9984669 |
ENST00000448631 | ENST00000302445 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - | 0.001533089 | 0.9984669 |
ENST00000602677 | ENST00000319410 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - | 0.001533089 | 0.9984669 |
ENST00000602677 | ENST00000302445 | RANBP10 | chr16 | 67839331 | - | KARS | chr16 | 75675621 | - | 0.001533089 | 0.9984669 |
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Fusion Genomic Features for RANBP10-KARS |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for RANBP10-KARS |
Go to FGviewer for the breakpoints of chr16:67839331-chr16:75675621 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | KARS |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:9278442, PubMed:18029264, PubMed:18272479). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:5338216, PubMed:14975237, PubMed:19524539, PubMed:23159739). {ECO:0000269|PubMed:14975237, ECO:0000269|PubMed:15851690, ECO:0000269|PubMed:18029264, ECO:0000269|PubMed:19524539, ECO:0000269|PubMed:28887846, ECO:0000269|PubMed:5338216, ECO:0000269|PubMed:9278442}.; FUNCTION: (Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation. {ECO:0000269|PubMed:15220430}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | KARS | chr16:67839331 | chr16:75675621 | ENST00000302445 | 0 | 14 | 323_325 | 20.666666666666668 | 598.0 | Nucleotide binding | ATP | |
Tgene | KARS | chr16:67839331 | chr16:75675621 | ENST00000302445 | 0 | 14 | 331_332 | 20.666666666666668 | 598.0 | Nucleotide binding | ATP | |
Tgene | KARS | chr16:67839331 | chr16:75675621 | ENST00000302445 | 0 | 14 | 494_495 | 20.666666666666668 | 598.0 | Nucleotide binding | ATP | |
Tgene | KARS | chr16:67839331 | chr16:75675621 | ENST00000302445 | 0 | 14 | 550_553 | 20.666666666666668 | 598.0 | Nucleotide binding | ATP | |
Tgene | KARS | chr16:67839331 | chr16:75675621 | ENST00000319410 | 1 | 15 | 323_325 | 48.666666666666664 | 626.0 | Nucleotide binding | ATP | |
Tgene | KARS | chr16:67839331 | chr16:75675621 | ENST00000319410 | 1 | 15 | 331_332 | 48.666666666666664 | 626.0 | Nucleotide binding | ATP | |
Tgene | KARS | chr16:67839331 | chr16:75675621 | ENST00000319410 | 1 | 15 | 494_495 | 48.666666666666664 | 626.0 | Nucleotide binding | ATP | |
Tgene | KARS | chr16:67839331 | chr16:75675621 | ENST00000319410 | 1 | 15 | 550_553 | 48.666666666666664 | 626.0 | Nucleotide binding | ATP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | RANBP10 | chr16:67839331 | chr16:75675621 | ENST00000317506 | - | 2 | 14 | 346_453 | 115.66666666666667 | 621.0 | Compositional bias | Note=Ser-rich |
Hgene | RANBP10 | chr16:67839331 | chr16:75675621 | ENST00000317506 | - | 2 | 14 | 253_285 | 115.66666666666667 | 621.0 | Domain | LisH |
Hgene | RANBP10 | chr16:67839331 | chr16:75675621 | ENST00000317506 | - | 2 | 14 | 291_348 | 115.66666666666667 | 621.0 | Domain | CTLH |
Hgene | RANBP10 | chr16:67839331 | chr16:75675621 | ENST00000317506 | - | 2 | 14 | 35_222 | 115.66666666666667 | 621.0 | Domain | B30.2/SPRY |
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Fusion Gene Sequence for RANBP10-KARS |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000317506_ENST00000319410_TCGA-61-2008-02A_RANBP10_chr16_67839331_-_KARS_chr16_75675621_length(transcript)=2366nt_BP=463nt GGACTCGGACTCGGTTTCCCTGCGGCCCAGGGAGGCTCACGGGCCATTGGCTGAGCGGGGCGGATCTGGTCCCGCTCCTCCCCGCCCCCA GTGACACAATAGTAGCTCCCTCCAAGATGGCGGCAGCGACGGCAGACCCGGGAGCTGGGAACCCGCAGCCTGGGGACTCCTCCGGCGGGG GCGCTGGGGGCGGGCTGCCGTCCCCTGGGGAGCAGGAGCTGAGCCGGCGCTTGCAGCGCCTGTATCCCGCGGTCAACCAGCAAGAGACTC CGCTGCCGCGCTCCTGGAGCCCCAAGGACAAATACAACTACATTGGTCTCTCCCAGGGCAACCTCCGCGTCCACTACAAAGGTCATGGCA AAAATCACAAAGATGCGGCCTCAGTGCGTGCCACCCACCCCATACCTGCTGCCTGTGGCATTTATTACTTTGAAGTGAAGATTGTCAGCA AAGGAAGAGATGGTGAGCTGAAGAGACGCCTGAAAGCTGAGAAGAAAGTAGCAGAGAAGGAGGCCAAACAGAAAGAGCTCAGTGAGAAAC AGCTAAGCCAAGCCACTGCTGCTGCCACCAACCACACCACTGATAATGGTGTGGGTCCTGAGGAAGAGAGCGTGGACCCAAATCAATACT ACAAAATCCGCAGTCAAGCAATTCATCAGCTGAAGGTCAATGGGGAAGACCCATACCCACACAAGTTCCATGTAGACATCTCACTCACTG ACTTCATCCAAAAATATAGTCACCTGCAGCCTGGGGATCACCTGACTGACATCACCTTAAAGGTGGCAGGTAGGATCCATGCCAAAAGAG CTTCTGGGGGAAAGCTCATCTTCTATGATCTTCGAGGAGAGGGGGTGAAGTTGCAAGTCATGGCCAATTCCAGAAATTATAAATCAGAAG AAGAATTTATTCATATTAATAACAAACTGCGTCGGGGAGACATAATTGGAGTTCAGGGGAATCCTGGTAAAACCAAGAAGGGTGAGCTGA GCATCATTCCGTATGAGATCACACTGCTGTCTCCCTGTTTGCATATGTTACCTCATCTTCACTTTGGCCTCAAAGACAAGGAAACAAGGT ATCGCCAGAGATACTTGGACTTGATCCTGAATGACTTTGTGAGGCAGAAATTTATCATCCGCTCTAAGATCATCACATATATAAGAAGTT TCTTAGATGAGCTGGGATTCCTAGAGATTGAAACTCCCATGATGAACATCATCCCAGGGGGAGCCGTGGCCAAGCCTTTCATCACTTATC ACAACGAGCTGGACATGAACTTATATATGAGAATTGCTCCAGAACTCTATCATAAGATGCTTGTGGTTGGTGGCATCGACCGGGTTTATG AAATTGGACGCCAGTTCCGGAATGAGGGGATTGATTTGACGCACAATCCTGAGTTCACCACCTGTGAGTTCTACATGGCCTATGCAGACT ATCACGATCTCATGGAAATCACGGAGAAGATGGTTTCAGGGATGGTGAAGCATATTACAGGCAGTTACAAGGTCACCTACCACCCAGATG GCCCAGAGGGCCAAGCCTACGATGTTGACTTCACCCCACCCTTCCGGCGAATCAACATGGTAGAAGAGCTTGAGAAAGCCCTGGGGATGA AGCTGCCAGAAACGAACCTCTTTGAAACTGAAGAAACTCGCAAAATTCTTGATGATATCTGTGTGGCAAAAGCTGTTGAATGCCCTCCAC CTCGGACCACAGCCAGGCTCCTTGACAAGCTTGTTGGGGAGTTCCTGGAAGTGACTTGCATCAATCCTACATTCATCTGTGATCACCCAC AGATAATGAGCCCTTTGGCTAAATGGCACCGCTCTAAAGAGGGTCTGACTGAGCGCTTTGAGCTGTTTGTCATGAAGAAAGAGATATGCA ATGCGTATACTGAGCTGAATGATCCCATGCGGCAGCGGCAGCTTTTTGAAGAACAGGCCAAGGCCAAGGCTGCAGGTGATGATGAGGCCA TGTTCATAGATGAAAACTTCTGTACTGCCCTGGAATATGGGCTGCCCCCCACAGCTGGCTGGGGCATGGGCATTGATCGAGTCGCCATGT TTCTCACGGACTCCAACAACATCAAGGAAGTACTTCTGTTTCCTGCCATGAAACCCGAAGACAAGAAGGAGAATGTAGCAACCACTGATA CACTGGAAAGCACAACAGTTGGCACTTCTGTCTAGAAAATAATAATTGCAAGTTGTATAACTCAGGCGTCTTTGCATTTCTGCGAAAGAT CAAGGTCTGCAAGGGAATTCTTGTGTGCTGCTTTCCATTTGACACCGCAGTTCTGTTCAGCCATCAGAAGAGAGACAAGGAATTAAAAAT >In-frame_ENST00000317506_ENST00000319410_TCGA-61-2008-02A_RANBP10_chr16_67839331_-_KARS_chr16_75675621_length(amino acids)=714AA_start in transcript=50_stop in transcript=2194 MSGADLVPLLPAPSDTIVAPSKMAAATADPGAGNPQPGDSSGGGAGGGLPSPGEQELSRRLQRLYPAVNQQETPLPRSWSPKDKYNYIGL SQGNLRVHYKGHGKNHKDAASVRATHPIPAACGIYYFEVKIVSKGRDGELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTTDNG VGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVK LQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQK FIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNP EFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKIL DDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFE -------------------------------------------------------------- >In-frame_ENST00000317506_ENST00000302445_TCGA-61-2008-02A_RANBP10_chr16_67839331_-_KARS_chr16_75675621_length(transcript)=2366nt_BP=463nt GGACTCGGACTCGGTTTCCCTGCGGCCCAGGGAGGCTCACGGGCCATTGGCTGAGCGGGGCGGATCTGGTCCCGCTCCTCCCCGCCCCCA GTGACACAATAGTAGCTCCCTCCAAGATGGCGGCAGCGACGGCAGACCCGGGAGCTGGGAACCCGCAGCCTGGGGACTCCTCCGGCGGGG GCGCTGGGGGCGGGCTGCCGTCCCCTGGGGAGCAGGAGCTGAGCCGGCGCTTGCAGCGCCTGTATCCCGCGGTCAACCAGCAAGAGACTC CGCTGCCGCGCTCCTGGAGCCCCAAGGACAAATACAACTACATTGGTCTCTCCCAGGGCAACCTCCGCGTCCACTACAAAGGTCATGGCA AAAATCACAAAGATGCGGCCTCAGTGCGTGCCACCCACCCCATACCTGCTGCCTGTGGCATTTATTACTTTGAAGTGAAGATTGTCAGCA AAGGAAGAGATGGTGAGCTGAAGAGACGCCTGAAAGCTGAGAAGAAAGTAGCAGAGAAGGAGGCCAAACAGAAAGAGCTCAGTGAGAAAC AGCTAAGCCAAGCCACTGCTGCTGCCACCAACCACACCACTGATAATGGTGTGGGTCCTGAGGAAGAGAGCGTGGACCCAAATCAATACT ACAAAATCCGCAGTCAAGCAATTCATCAGCTGAAGGTCAATGGGGAAGACCCATACCCACACAAGTTCCATGTAGACATCTCACTCACTG ACTTCATCCAAAAATATAGTCACCTGCAGCCTGGGGATCACCTGACTGACATCACCTTAAAGGTGGCAGGTAGGATCCATGCCAAAAGAG CTTCTGGGGGAAAGCTCATCTTCTATGATCTTCGAGGAGAGGGGGTGAAGTTGCAAGTCATGGCCAATTCCAGAAATTATAAATCAGAAG AAGAATTTATTCATATTAATAACAAACTGCGTCGGGGAGACATAATTGGAGTTCAGGGGAATCCTGGTAAAACCAAGAAGGGTGAGCTGA GCATCATTCCGTATGAGATCACACTGCTGTCTCCCTGTTTGCATATGTTACCTCATCTTCACTTTGGCCTCAAAGACAAGGAAACAAGGT ATCGCCAGAGATACTTGGACTTGATCCTGAATGACTTTGTGAGGCAGAAATTTATCATCCGCTCTAAGATCATCACATATATAAGAAGTT TCTTAGATGAGCTGGGATTCCTAGAGATTGAAACTCCCATGATGAACATCATCCCAGGGGGAGCCGTGGCCAAGCCTTTCATCACTTATC ACAACGAGCTGGACATGAACTTATATATGAGAATTGCTCCAGAACTCTATCATAAGATGCTTGTGGTTGGTGGCATCGACCGGGTTTATG AAATTGGACGCCAGTTCCGGAATGAGGGGATTGATTTGACGCACAATCCTGAGTTCACCACCTGTGAGTTCTACATGGCCTATGCAGACT ATCACGATCTCATGGAAATCACGGAGAAGATGGTTTCAGGGATGGTGAAGCATATTACAGGCAGTTACAAGGTCACCTACCACCCAGATG GCCCAGAGGGCCAAGCCTACGATGTTGACTTCACCCCACCCTTCCGGCGAATCAACATGGTAGAAGAGCTTGAGAAAGCCCTGGGGATGA AGCTGCCAGAAACGAACCTCTTTGAAACTGAAGAAACTCGCAAAATTCTTGATGATATCTGTGTGGCAAAAGCTGTTGAATGCCCTCCAC CTCGGACCACAGCCAGGCTCCTTGACAAGCTTGTTGGGGAGTTCCTGGAAGTGACTTGCATCAATCCTACATTCATCTGTGATCACCCAC AGATAATGAGCCCTTTGGCTAAATGGCACCGCTCTAAAGAGGGTCTGACTGAGCGCTTTGAGCTGTTTGTCATGAAGAAAGAGATATGCA ATGCGTATACTGAGCTGAATGATCCCATGCGGCAGCGGCAGCTTTTTGAAGAACAGGCCAAGGCCAAGGCTGCAGGTGATGATGAGGCCA TGTTCATAGATGAAAACTTCTGTACTGCCCTGGAATATGGGCTGCCCCCCACAGCTGGCTGGGGCATGGGCATTGATCGAGTCGCCATGT TTCTCACGGACTCCAACAACATCAAGGAAGTACTTCTGTTTCCTGCCATGAAACCCGAAGACAAGAAGGAGAATGTAGCAACCACTGATA CACTGGAAAGCACAACAGTTGGCACTTCTGTCTAGAAAATAATAATTGCAAGTTGTATAACTCAGGCGTCTTTGCATTTCTGCGAAAGAT CAAGGTCTGCAAGGGAATTCTTGTGTGCTGCTTTCCATTTGACACCGCAGTTCTGTTCAGCCATCAGAAGAGAGACAAGGAATTAAAAAT >In-frame_ENST00000317506_ENST00000302445_TCGA-61-2008-02A_RANBP10_chr16_67839331_-_KARS_chr16_75675621_length(amino acids)=714AA_start in transcript=50_stop in transcript=2194 MSGADLVPLLPAPSDTIVAPSKMAAATADPGAGNPQPGDSSGGGAGGGLPSPGEQELSRRLQRLYPAVNQQETPLPRSWSPKDKYNYIGL SQGNLRVHYKGHGKNHKDAASVRATHPIPAACGIYYFEVKIVSKGRDGELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTTDNG VGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVK LQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQK FIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNP EFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKIL DDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFE -------------------------------------------------------------- >In-frame_ENST00000448631_ENST00000319410_TCGA-61-2008-02A_RANBP10_chr16_67839331_-_KARS_chr16_75675621_length(transcript)=2274nt_BP=371nt GACACAATAGTAGCTCCCTCCAAGATGGCGGCAGCGACGGCAGACCCGGGAGCTGGGAACCCGCAGCCTGGGGACTCCTCCGGCGGGGGC GCTGGGGGCGGGCTGCCGTCCCCTGGGGAGCAGGAGCTGAGCCGGCGCTTGCAGCGCCTGTATCCCGCGGTCAACCAGCAAGAGACTCCG CTGCCGCGCTCCTGGAGCCCCAAGGACAAATACAACTACATTGGTCTCTCCCAGGGCAACCTCCGCGTCCACTACAAAGGTCATGGCAAA AATCACAAAGATGCGGCCTCAGTGCGTGCCACCCACCCCATACCTGCTGCCTGTGGCATTTATTACTTTGAAGTGAAGATTGTCAGCAAA GGAAGAGATGGTGAGCTGAAGAGACGCCTGAAAGCTGAGAAGAAAGTAGCAGAGAAGGAGGCCAAACAGAAAGAGCTCAGTGAGAAACAG CTAAGCCAAGCCACTGCTGCTGCCACCAACCACACCACTGATAATGGTGTGGGTCCTGAGGAAGAGAGCGTGGACCCAAATCAATACTAC AAAATCCGCAGTCAAGCAATTCATCAGCTGAAGGTCAATGGGGAAGACCCATACCCACACAAGTTCCATGTAGACATCTCACTCACTGAC TTCATCCAAAAATATAGTCACCTGCAGCCTGGGGATCACCTGACTGACATCACCTTAAAGGTGGCAGGTAGGATCCATGCCAAAAGAGCT TCTGGGGGAAAGCTCATCTTCTATGATCTTCGAGGAGAGGGGGTGAAGTTGCAAGTCATGGCCAATTCCAGAAATTATAAATCAGAAGAA GAATTTATTCATATTAATAACAAACTGCGTCGGGGAGACATAATTGGAGTTCAGGGGAATCCTGGTAAAACCAAGAAGGGTGAGCTGAGC ATCATTCCGTATGAGATCACACTGCTGTCTCCCTGTTTGCATATGTTACCTCATCTTCACTTTGGCCTCAAAGACAAGGAAACAAGGTAT CGCCAGAGATACTTGGACTTGATCCTGAATGACTTTGTGAGGCAGAAATTTATCATCCGCTCTAAGATCATCACATATATAAGAAGTTTC TTAGATGAGCTGGGATTCCTAGAGATTGAAACTCCCATGATGAACATCATCCCAGGGGGAGCCGTGGCCAAGCCTTTCATCACTTATCAC AACGAGCTGGACATGAACTTATATATGAGAATTGCTCCAGAACTCTATCATAAGATGCTTGTGGTTGGTGGCATCGACCGGGTTTATGAA ATTGGACGCCAGTTCCGGAATGAGGGGATTGATTTGACGCACAATCCTGAGTTCACCACCTGTGAGTTCTACATGGCCTATGCAGACTAT CACGATCTCATGGAAATCACGGAGAAGATGGTTTCAGGGATGGTGAAGCATATTACAGGCAGTTACAAGGTCACCTACCACCCAGATGGC CCAGAGGGCCAAGCCTACGATGTTGACTTCACCCCACCCTTCCGGCGAATCAACATGGTAGAAGAGCTTGAGAAAGCCCTGGGGATGAAG CTGCCAGAAACGAACCTCTTTGAAACTGAAGAAACTCGCAAAATTCTTGATGATATCTGTGTGGCAAAAGCTGTTGAATGCCCTCCACCT CGGACCACAGCCAGGCTCCTTGACAAGCTTGTTGGGGAGTTCCTGGAAGTGACTTGCATCAATCCTACATTCATCTGTGATCACCCACAG ATAATGAGCCCTTTGGCTAAATGGCACCGCTCTAAAGAGGGTCTGACTGAGCGCTTTGAGCTGTTTGTCATGAAGAAAGAGATATGCAAT GCGTATACTGAGCTGAATGATCCCATGCGGCAGCGGCAGCTTTTTGAAGAACAGGCCAAGGCCAAGGCTGCAGGTGATGATGAGGCCATG TTCATAGATGAAAACTTCTGTACTGCCCTGGAATATGGGCTGCCCCCCACAGCTGGCTGGGGCATGGGCATTGATCGAGTCGCCATGTTT CTCACGGACTCCAACAACATCAAGGAAGTACTTCTGTTTCCTGCCATGAAACCCGAAGACAAGAAGGAGAATGTAGCAACCACTGATACA CTGGAAAGCACAACAGTTGGCACTTCTGTCTAGAAAATAATAATTGCAAGTTGTATAACTCAGGCGTCTTTGCATTTCTGCGAAAGATCA AGGTCTGCAAGGGAATTCTTGTGTGCTGCTTTCCATTTGACACCGCAGTTCTGTTCAGCCATCAGAAGAGAGACAAGGAATTAAAAATTT >In-frame_ENST00000448631_ENST00000319410_TCGA-61-2008-02A_RANBP10_chr16_67839331_-_KARS_chr16_75675621_length(amino acids)=692AA_start in transcript=24_stop in transcript=2102 MAAATADPGAGNPQPGDSSGGGAGGGLPSPGEQELSRRLQRLYPAVNQQETPLPRSWSPKDKYNYIGLSQGNLRVHYKGHGKNHKDAASV RATHPIPAACGIYYFEVKIVSKGRDGELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTTDNGVGPEEESVDPNQYYKIRSQAIH QLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNK LRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLE IETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITE KMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLD KLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCT -------------------------------------------------------------- >In-frame_ENST00000448631_ENST00000302445_TCGA-61-2008-02A_RANBP10_chr16_67839331_-_KARS_chr16_75675621_length(transcript)=2274nt_BP=371nt GACACAATAGTAGCTCCCTCCAAGATGGCGGCAGCGACGGCAGACCCGGGAGCTGGGAACCCGCAGCCTGGGGACTCCTCCGGCGGGGGC GCTGGGGGCGGGCTGCCGTCCCCTGGGGAGCAGGAGCTGAGCCGGCGCTTGCAGCGCCTGTATCCCGCGGTCAACCAGCAAGAGACTCCG CTGCCGCGCTCCTGGAGCCCCAAGGACAAATACAACTACATTGGTCTCTCCCAGGGCAACCTCCGCGTCCACTACAAAGGTCATGGCAAA AATCACAAAGATGCGGCCTCAGTGCGTGCCACCCACCCCATACCTGCTGCCTGTGGCATTTATTACTTTGAAGTGAAGATTGTCAGCAAA GGAAGAGATGGTGAGCTGAAGAGACGCCTGAAAGCTGAGAAGAAAGTAGCAGAGAAGGAGGCCAAACAGAAAGAGCTCAGTGAGAAACAG CTAAGCCAAGCCACTGCTGCTGCCACCAACCACACCACTGATAATGGTGTGGGTCCTGAGGAAGAGAGCGTGGACCCAAATCAATACTAC AAAATCCGCAGTCAAGCAATTCATCAGCTGAAGGTCAATGGGGAAGACCCATACCCACACAAGTTCCATGTAGACATCTCACTCACTGAC TTCATCCAAAAATATAGTCACCTGCAGCCTGGGGATCACCTGACTGACATCACCTTAAAGGTGGCAGGTAGGATCCATGCCAAAAGAGCT TCTGGGGGAAAGCTCATCTTCTATGATCTTCGAGGAGAGGGGGTGAAGTTGCAAGTCATGGCCAATTCCAGAAATTATAAATCAGAAGAA GAATTTATTCATATTAATAACAAACTGCGTCGGGGAGACATAATTGGAGTTCAGGGGAATCCTGGTAAAACCAAGAAGGGTGAGCTGAGC ATCATTCCGTATGAGATCACACTGCTGTCTCCCTGTTTGCATATGTTACCTCATCTTCACTTTGGCCTCAAAGACAAGGAAACAAGGTAT CGCCAGAGATACTTGGACTTGATCCTGAATGACTTTGTGAGGCAGAAATTTATCATCCGCTCTAAGATCATCACATATATAAGAAGTTTC TTAGATGAGCTGGGATTCCTAGAGATTGAAACTCCCATGATGAACATCATCCCAGGGGGAGCCGTGGCCAAGCCTTTCATCACTTATCAC AACGAGCTGGACATGAACTTATATATGAGAATTGCTCCAGAACTCTATCATAAGATGCTTGTGGTTGGTGGCATCGACCGGGTTTATGAA ATTGGACGCCAGTTCCGGAATGAGGGGATTGATTTGACGCACAATCCTGAGTTCACCACCTGTGAGTTCTACATGGCCTATGCAGACTAT CACGATCTCATGGAAATCACGGAGAAGATGGTTTCAGGGATGGTGAAGCATATTACAGGCAGTTACAAGGTCACCTACCACCCAGATGGC CCAGAGGGCCAAGCCTACGATGTTGACTTCACCCCACCCTTCCGGCGAATCAACATGGTAGAAGAGCTTGAGAAAGCCCTGGGGATGAAG CTGCCAGAAACGAACCTCTTTGAAACTGAAGAAACTCGCAAAATTCTTGATGATATCTGTGTGGCAAAAGCTGTTGAATGCCCTCCACCT CGGACCACAGCCAGGCTCCTTGACAAGCTTGTTGGGGAGTTCCTGGAAGTGACTTGCATCAATCCTACATTCATCTGTGATCACCCACAG ATAATGAGCCCTTTGGCTAAATGGCACCGCTCTAAAGAGGGTCTGACTGAGCGCTTTGAGCTGTTTGTCATGAAGAAAGAGATATGCAAT GCGTATACTGAGCTGAATGATCCCATGCGGCAGCGGCAGCTTTTTGAAGAACAGGCCAAGGCCAAGGCTGCAGGTGATGATGAGGCCATG TTCATAGATGAAAACTTCTGTACTGCCCTGGAATATGGGCTGCCCCCCACAGCTGGCTGGGGCATGGGCATTGATCGAGTCGCCATGTTT CTCACGGACTCCAACAACATCAAGGAAGTACTTCTGTTTCCTGCCATGAAACCCGAAGACAAGAAGGAGAATGTAGCAACCACTGATACA CTGGAAAGCACAACAGTTGGCACTTCTGTCTAGAAAATAATAATTGCAAGTTGTATAACTCAGGCGTCTTTGCATTTCTGCGAAAGATCA AGGTCTGCAAGGGAATTCTTGTGTGCTGCTTTCCATTTGACACCGCAGTTCTGTTCAGCCATCAGAAGAGAGACAAGGAATTAAAAATTT >In-frame_ENST00000448631_ENST00000302445_TCGA-61-2008-02A_RANBP10_chr16_67839331_-_KARS_chr16_75675621_length(amino acids)=692AA_start in transcript=24_stop in transcript=2102 MAAATADPGAGNPQPGDSSGGGAGGGLPSPGEQELSRRLQRLYPAVNQQETPLPRSWSPKDKYNYIGLSQGNLRVHYKGHGKNHKDAASV RATHPIPAACGIYYFEVKIVSKGRDGELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTTDNGVGPEEESVDPNQYYKIRSQAIH QLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNK LRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLE IETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITE KMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLD KLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCT -------------------------------------------------------------- >In-frame_ENST00000602677_ENST00000319410_TCGA-61-2008-02A_RANBP10_chr16_67839331_-_KARS_chr16_75675621_length(transcript)=2274nt_BP=371nt GACACAATAGTAGCTCCCTCCAAGATGGCGGCAGCGACGGCAGACCCGGGAGCTGGGAACCCGCAGCCTGGGGACTCCTCCGGCGGGGGC GCTGGGGGCGGGCTGCCGTCCCCTGGGGAGCAGGAGCTGAGCCGGCGCTTGCAGCGCCTGTATCCCGCGGTCAACCAGCAAGAGACTCCG CTGCCGCGCTCCTGGAGCCCCAAGGACAAATACAACTACATTGGTCTCTCCCAGGGCAACCTCCGCGTCCACTACAAAGGTCATGGCAAA AATCACAAAGATGCGGCCTCAGTGCGTGCCACCCACCCCATACCTGCTGCCTGTGGCATTTATTACTTTGAAGTGAAGATTGTCAGCAAA GGAAGAGATGGTGAGCTGAAGAGACGCCTGAAAGCTGAGAAGAAAGTAGCAGAGAAGGAGGCCAAACAGAAAGAGCTCAGTGAGAAACAG CTAAGCCAAGCCACTGCTGCTGCCACCAACCACACCACTGATAATGGTGTGGGTCCTGAGGAAGAGAGCGTGGACCCAAATCAATACTAC AAAATCCGCAGTCAAGCAATTCATCAGCTGAAGGTCAATGGGGAAGACCCATACCCACACAAGTTCCATGTAGACATCTCACTCACTGAC TTCATCCAAAAATATAGTCACCTGCAGCCTGGGGATCACCTGACTGACATCACCTTAAAGGTGGCAGGTAGGATCCATGCCAAAAGAGCT TCTGGGGGAAAGCTCATCTTCTATGATCTTCGAGGAGAGGGGGTGAAGTTGCAAGTCATGGCCAATTCCAGAAATTATAAATCAGAAGAA GAATTTATTCATATTAATAACAAACTGCGTCGGGGAGACATAATTGGAGTTCAGGGGAATCCTGGTAAAACCAAGAAGGGTGAGCTGAGC ATCATTCCGTATGAGATCACACTGCTGTCTCCCTGTTTGCATATGTTACCTCATCTTCACTTTGGCCTCAAAGACAAGGAAACAAGGTAT CGCCAGAGATACTTGGACTTGATCCTGAATGACTTTGTGAGGCAGAAATTTATCATCCGCTCTAAGATCATCACATATATAAGAAGTTTC TTAGATGAGCTGGGATTCCTAGAGATTGAAACTCCCATGATGAACATCATCCCAGGGGGAGCCGTGGCCAAGCCTTTCATCACTTATCAC AACGAGCTGGACATGAACTTATATATGAGAATTGCTCCAGAACTCTATCATAAGATGCTTGTGGTTGGTGGCATCGACCGGGTTTATGAA ATTGGACGCCAGTTCCGGAATGAGGGGATTGATTTGACGCACAATCCTGAGTTCACCACCTGTGAGTTCTACATGGCCTATGCAGACTAT CACGATCTCATGGAAATCACGGAGAAGATGGTTTCAGGGATGGTGAAGCATATTACAGGCAGTTACAAGGTCACCTACCACCCAGATGGC CCAGAGGGCCAAGCCTACGATGTTGACTTCACCCCACCCTTCCGGCGAATCAACATGGTAGAAGAGCTTGAGAAAGCCCTGGGGATGAAG CTGCCAGAAACGAACCTCTTTGAAACTGAAGAAACTCGCAAAATTCTTGATGATATCTGTGTGGCAAAAGCTGTTGAATGCCCTCCACCT CGGACCACAGCCAGGCTCCTTGACAAGCTTGTTGGGGAGTTCCTGGAAGTGACTTGCATCAATCCTACATTCATCTGTGATCACCCACAG ATAATGAGCCCTTTGGCTAAATGGCACCGCTCTAAAGAGGGTCTGACTGAGCGCTTTGAGCTGTTTGTCATGAAGAAAGAGATATGCAAT GCGTATACTGAGCTGAATGATCCCATGCGGCAGCGGCAGCTTTTTGAAGAACAGGCCAAGGCCAAGGCTGCAGGTGATGATGAGGCCATG TTCATAGATGAAAACTTCTGTACTGCCCTGGAATATGGGCTGCCCCCCACAGCTGGCTGGGGCATGGGCATTGATCGAGTCGCCATGTTT CTCACGGACTCCAACAACATCAAGGAAGTACTTCTGTTTCCTGCCATGAAACCCGAAGACAAGAAGGAGAATGTAGCAACCACTGATACA CTGGAAAGCACAACAGTTGGCACTTCTGTCTAGAAAATAATAATTGCAAGTTGTATAACTCAGGCGTCTTTGCATTTCTGCGAAAGATCA AGGTCTGCAAGGGAATTCTTGTGTGCTGCTTTCCATTTGACACCGCAGTTCTGTTCAGCCATCAGAAGAGAGACAAGGAATTAAAAATTT >In-frame_ENST00000602677_ENST00000319410_TCGA-61-2008-02A_RANBP10_chr16_67839331_-_KARS_chr16_75675621_length(amino acids)=692AA_start in transcript=24_stop in transcript=2102 MAAATADPGAGNPQPGDSSGGGAGGGLPSPGEQELSRRLQRLYPAVNQQETPLPRSWSPKDKYNYIGLSQGNLRVHYKGHGKNHKDAASV RATHPIPAACGIYYFEVKIVSKGRDGELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTTDNGVGPEEESVDPNQYYKIRSQAIH QLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNK LRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLE IETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITE KMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLD KLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCT -------------------------------------------------------------- >In-frame_ENST00000602677_ENST00000302445_TCGA-61-2008-02A_RANBP10_chr16_67839331_-_KARS_chr16_75675621_length(transcript)=2274nt_BP=371nt GACACAATAGTAGCTCCCTCCAAGATGGCGGCAGCGACGGCAGACCCGGGAGCTGGGAACCCGCAGCCTGGGGACTCCTCCGGCGGGGGC GCTGGGGGCGGGCTGCCGTCCCCTGGGGAGCAGGAGCTGAGCCGGCGCTTGCAGCGCCTGTATCCCGCGGTCAACCAGCAAGAGACTCCG CTGCCGCGCTCCTGGAGCCCCAAGGACAAATACAACTACATTGGTCTCTCCCAGGGCAACCTCCGCGTCCACTACAAAGGTCATGGCAAA AATCACAAAGATGCGGCCTCAGTGCGTGCCACCCACCCCATACCTGCTGCCTGTGGCATTTATTACTTTGAAGTGAAGATTGTCAGCAAA GGAAGAGATGGTGAGCTGAAGAGACGCCTGAAAGCTGAGAAGAAAGTAGCAGAGAAGGAGGCCAAACAGAAAGAGCTCAGTGAGAAACAG CTAAGCCAAGCCACTGCTGCTGCCACCAACCACACCACTGATAATGGTGTGGGTCCTGAGGAAGAGAGCGTGGACCCAAATCAATACTAC AAAATCCGCAGTCAAGCAATTCATCAGCTGAAGGTCAATGGGGAAGACCCATACCCACACAAGTTCCATGTAGACATCTCACTCACTGAC TTCATCCAAAAATATAGTCACCTGCAGCCTGGGGATCACCTGACTGACATCACCTTAAAGGTGGCAGGTAGGATCCATGCCAAAAGAGCT TCTGGGGGAAAGCTCATCTTCTATGATCTTCGAGGAGAGGGGGTGAAGTTGCAAGTCATGGCCAATTCCAGAAATTATAAATCAGAAGAA GAATTTATTCATATTAATAACAAACTGCGTCGGGGAGACATAATTGGAGTTCAGGGGAATCCTGGTAAAACCAAGAAGGGTGAGCTGAGC ATCATTCCGTATGAGATCACACTGCTGTCTCCCTGTTTGCATATGTTACCTCATCTTCACTTTGGCCTCAAAGACAAGGAAACAAGGTAT CGCCAGAGATACTTGGACTTGATCCTGAATGACTTTGTGAGGCAGAAATTTATCATCCGCTCTAAGATCATCACATATATAAGAAGTTTC TTAGATGAGCTGGGATTCCTAGAGATTGAAACTCCCATGATGAACATCATCCCAGGGGGAGCCGTGGCCAAGCCTTTCATCACTTATCAC AACGAGCTGGACATGAACTTATATATGAGAATTGCTCCAGAACTCTATCATAAGATGCTTGTGGTTGGTGGCATCGACCGGGTTTATGAA ATTGGACGCCAGTTCCGGAATGAGGGGATTGATTTGACGCACAATCCTGAGTTCACCACCTGTGAGTTCTACATGGCCTATGCAGACTAT CACGATCTCATGGAAATCACGGAGAAGATGGTTTCAGGGATGGTGAAGCATATTACAGGCAGTTACAAGGTCACCTACCACCCAGATGGC CCAGAGGGCCAAGCCTACGATGTTGACTTCACCCCACCCTTCCGGCGAATCAACATGGTAGAAGAGCTTGAGAAAGCCCTGGGGATGAAG CTGCCAGAAACGAACCTCTTTGAAACTGAAGAAACTCGCAAAATTCTTGATGATATCTGTGTGGCAAAAGCTGTTGAATGCCCTCCACCT CGGACCACAGCCAGGCTCCTTGACAAGCTTGTTGGGGAGTTCCTGGAAGTGACTTGCATCAATCCTACATTCATCTGTGATCACCCACAG ATAATGAGCCCTTTGGCTAAATGGCACCGCTCTAAAGAGGGTCTGACTGAGCGCTTTGAGCTGTTTGTCATGAAGAAAGAGATATGCAAT GCGTATACTGAGCTGAATGATCCCATGCGGCAGCGGCAGCTTTTTGAAGAACAGGCCAAGGCCAAGGCTGCAGGTGATGATGAGGCCATG TTCATAGATGAAAACTTCTGTACTGCCCTGGAATATGGGCTGCCCCCCACAGCTGGCTGGGGCATGGGCATTGATCGAGTCGCCATGTTT CTCACGGACTCCAACAACATCAAGGAAGTACTTCTGTTTCCTGCCATGAAACCCGAAGACAAGAAGGAGAATGTAGCAACCACTGATACA CTGGAAAGCACAACAGTTGGCACTTCTGTCTAGAAAATAATAATTGCAAGTTGTATAACTCAGGCGTCTTTGCATTTCTGCGAAAGATCA AGGTCTGCAAGGGAATTCTTGTGTGCTGCTTTCCATTTGACACCGCAGTTCTGTTCAGCCATCAGAAGAGAGACAAGGAATTAAAAATTT >In-frame_ENST00000602677_ENST00000302445_TCGA-61-2008-02A_RANBP10_chr16_67839331_-_KARS_chr16_75675621_length(amino acids)=692AA_start in transcript=24_stop in transcript=2102 MAAATADPGAGNPQPGDSSGGGAGGGLPSPGEQELSRRLQRLYPAVNQQETPLPRSWSPKDKYNYIGLSQGNLRVHYKGHGKNHKDAASV RATHPIPAACGIYYFEVKIVSKGRDGELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTTDNGVGPEEESVDPNQYYKIRSQAIH QLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNK LRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLE IETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITE KMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLD KLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCT -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for RANBP10-KARS |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for RANBP10-KARS |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | KARS | Q15046 | DB00123 | L-Lysine | Small molecule | Approved|Nutraceutical | |
Tgene | KARS | Q15046 | DB00123 | L-Lysine | Small molecule | Approved|Nutraceutical | |
Tgene | KARS | Q15046 | DB00123 | L-Lysine | Small molecule | Approved|Nutraceutical |
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Related Diseases for RANBP10-KARS |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RANBP10 | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human |
Hgene | RANBP10 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | RANBP10 | C0235874 | Disease Exacerbation | 1 | CTD_human |
Hgene | RANBP10 | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human |