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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RANBP3-N6AMT2 (FusionGDB2 ID:71633)

Fusion Gene Summary for RANBP3-N6AMT2

check button Fusion gene summary
Fusion gene informationFusion gene name: RANBP3-N6AMT2
Fusion gene ID: 71633
HgeneTgene
Gene symbol

RANBP3

N6AMT2

Gene ID

8498

221143

Gene nameRAN binding protein 3EEF1A lysine methyltransferase 1
Synonyms-ESP13|N6AMT2
Cytomap

19p13.3

13q12.11

Type of geneprotein-codingprotein-coding
Descriptionran-binding protein 3epididymis secretory sperm binding proteinEEF1A lysine methyltransferase 1N-6 adenine-specific DNA methyltransferase 2 (putative)eukaryotic translation elongation factor 1 alpha lysine methyltransferase 1n(6)-adenine-specific DNA methyltransferase 2protein-lysine N-methyltransferase N6AMT2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000439268, ENST00000340578, 
ENST00000541471, ENST00000591092, 
ENST00000034275, ENST00000591124, 
ENST00000382758, ENST00000382754, 
ENST00000460374, 
Fusion gene scores* DoF score10 X 6 X 8=4802 X 3 X 2=12
# samples 132
** MAII scorelog2(13/480*10)=-1.88452278258006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RANBP3 [Title/Abstract] AND N6AMT2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRANBP3(5951404)-N6AMT2(21311944), # samples:2
Anticipated loss of major functional domain due to fusion event.RANBP3-N6AMT2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneN6AMT2

GO:0018022

peptidyl-lysine methylation

26545399


check buttonFusion gene breakpoints across RANBP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across N6AMT2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-MS-A51U-01ARANBP3chr19

5978072

-N6AMT2chr13

21306260

-
ChimerDB4BRCATCGA-MS-A51U-01ARANBP3chr19

5951404

-N6AMT2chr13

21303355

-
ChimerDB4BRCATCGA-MS-A51U-01ARANBP3chr19

5951404

-N6AMT2chr13

21311944

-
ChimerDB4BRCATCGA-MS-A51U-01ARANBP3chr19

5951404

-N6AMT2chr13

21311944

-


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Fusion Gene ORF analysis for RANBP3-N6AMT2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000439268ENST00000382758RANBP3chr19

5978072

-N6AMT2chr13

21306260

-
Frame-shiftENST00000439268ENST00000382754RANBP3chr19

5978072

-N6AMT2chr13

21306260

-
5CDS-intronENST00000439268ENST00000460374RANBP3chr19

5978072

-N6AMT2chr13

21306260

-
Frame-shiftENST00000340578ENST00000382758RANBP3chr19

5978072

-N6AMT2chr13

21306260

-
Frame-shiftENST00000340578ENST00000382754RANBP3chr19

5978072

-N6AMT2chr13

21306260

-
5CDS-intronENST00000340578ENST00000460374RANBP3chr19

5978072

-N6AMT2chr13

21306260

-
Frame-shiftENST00000541471ENST00000382758RANBP3chr19

5978072

-N6AMT2chr13

21306260

-
Frame-shiftENST00000541471ENST00000382754RANBP3chr19

5978072

-N6AMT2chr13

21306260

-
5CDS-intronENST00000541471ENST00000460374RANBP3chr19

5978072

-N6AMT2chr13

21306260

-
Frame-shiftENST00000591092ENST00000382758RANBP3chr19

5978072

-N6AMT2chr13

21306260

-
Frame-shiftENST00000591092ENST00000382754RANBP3chr19

5978072

-N6AMT2chr13

21306260

-
5CDS-intronENST00000591092ENST00000460374RANBP3chr19

5978072

-N6AMT2chr13

21306260

-
Frame-shiftENST00000034275ENST00000382758RANBP3chr19

5978072

-N6AMT2chr13

21306260

-
Frame-shiftENST00000034275ENST00000382754RANBP3chr19

5978072

-N6AMT2chr13

21306260

-
5CDS-intronENST00000034275ENST00000460374RANBP3chr19

5978072

-N6AMT2chr13

21306260

-
5UTR-3CDSENST00000591124ENST00000382758RANBP3chr19

5978072

-N6AMT2chr13

21306260

-
5UTR-3CDSENST00000591124ENST00000382754RANBP3chr19

5978072

-N6AMT2chr13

21306260

-
5UTR-intronENST00000591124ENST00000460374RANBP3chr19

5978072

-N6AMT2chr13

21306260

-
Frame-shiftENST00000439268ENST00000382758RANBP3chr19

5951404

-N6AMT2chr13

21303355

-
Frame-shiftENST00000439268ENST00000382754RANBP3chr19

5951404

-N6AMT2chr13

21303355

-
5CDS-intronENST00000439268ENST00000460374RANBP3chr19

5951404

-N6AMT2chr13

21303355

-
Frame-shiftENST00000340578ENST00000382758RANBP3chr19

5951404

-N6AMT2chr13

21303355

-
Frame-shiftENST00000340578ENST00000382754RANBP3chr19

5951404

-N6AMT2chr13

21303355

-
5CDS-intronENST00000340578ENST00000460374RANBP3chr19

5951404

-N6AMT2chr13

21303355

-
intron-3CDSENST00000541471ENST00000382758RANBP3chr19

5951404

-N6AMT2chr13

21303355

-
intron-3CDSENST00000541471ENST00000382754RANBP3chr19

5951404

-N6AMT2chr13

21303355

-
intron-intronENST00000541471ENST00000460374RANBP3chr19

5951404

-N6AMT2chr13

21303355

-
intron-3CDSENST00000591092ENST00000382758RANBP3chr19

5951404

-N6AMT2chr13

21303355

-
intron-3CDSENST00000591092ENST00000382754RANBP3chr19

5951404

-N6AMT2chr13

21303355

-
intron-intronENST00000591092ENST00000460374RANBP3chr19

5951404

-N6AMT2chr13

21303355

-
intron-3CDSENST00000034275ENST00000382758RANBP3chr19

5951404

-N6AMT2chr13

21303355

-
intron-3CDSENST00000034275ENST00000382754RANBP3chr19

5951404

-N6AMT2chr13

21303355

-
intron-intronENST00000034275ENST00000460374RANBP3chr19

5951404

-N6AMT2chr13

21303355

-
intron-3CDSENST00000591124ENST00000382758RANBP3chr19

5951404

-N6AMT2chr13

21303355

-
intron-3CDSENST00000591124ENST00000382754RANBP3chr19

5951404

-N6AMT2chr13

21303355

-
intron-intronENST00000591124ENST00000460374RANBP3chr19

5951404

-N6AMT2chr13

21303355

-
In-frameENST00000439268ENST00000382758RANBP3chr19

5951404

-N6AMT2chr13

21311944

-
In-frameENST00000439268ENST00000382754RANBP3chr19

5951404

-N6AMT2chr13

21311944

-
5CDS-intronENST00000439268ENST00000460374RANBP3chr19

5951404

-N6AMT2chr13

21311944

-
In-frameENST00000340578ENST00000382758RANBP3chr19

5951404

-N6AMT2chr13

21311944

-
In-frameENST00000340578ENST00000382754RANBP3chr19

5951404

-N6AMT2chr13

21311944

-
5CDS-intronENST00000340578ENST00000460374RANBP3chr19

5951404

-N6AMT2chr13

21311944

-
intron-3CDSENST00000541471ENST00000382758RANBP3chr19

5951404

-N6AMT2chr13

21311944

-
intron-3CDSENST00000541471ENST00000382754RANBP3chr19

5951404

-N6AMT2chr13

21311944

-
intron-intronENST00000541471ENST00000460374RANBP3chr19

5951404

-N6AMT2chr13

21311944

-
intron-3CDSENST00000591092ENST00000382758RANBP3chr19

5951404

-N6AMT2chr13

21311944

-
intron-3CDSENST00000591092ENST00000382754RANBP3chr19

5951404

-N6AMT2chr13

21311944

-
intron-intronENST00000591092ENST00000460374RANBP3chr19

5951404

-N6AMT2chr13

21311944

-
intron-3CDSENST00000034275ENST00000382758RANBP3chr19

5951404

-N6AMT2chr13

21311944

-
intron-3CDSENST00000034275ENST00000382754RANBP3chr19

5951404

-N6AMT2chr13

21311944

-
intron-intronENST00000034275ENST00000460374RANBP3chr19

5951404

-N6AMT2chr13

21311944

-
intron-3CDSENST00000591124ENST00000382758RANBP3chr19

5951404

-N6AMT2chr13

21311944

-
intron-3CDSENST00000591124ENST00000382754RANBP3chr19

5951404

-N6AMT2chr13

21311944

-
intron-intronENST00000591124ENST00000460374RANBP3chr19

5951404

-N6AMT2chr13

21311944

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000439268RANBP3chr195951404-ENST00000382758N6AMT2chr1321311944-115830826808260
ENST00000439268RANBP3chr195951404-ENST00000382754N6AMT2chr1321311944-95830826808260
ENST00000340578RANBP3chr195951404-ENST00000382758N6AMT2chr1321311944-119034058840260
ENST00000340578RANBP3chr195951404-ENST00000382754N6AMT2chr1321311944-99034058840260

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000439268ENST00000382758RANBP3chr195951404-N6AMT2chr1321311944-0.0035209150.9964791
ENST00000439268ENST00000382754RANBP3chr195951404-N6AMT2chr1321311944-0.0042652210.99573475
ENST00000340578ENST00000382758RANBP3chr195951404-N6AMT2chr1321311944-0.0036715810.9963284
ENST00000340578ENST00000382754RANBP3chr195951404-N6AMT2chr1321311944-0.0044785860.9955214

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Fusion Genomic Features for RANBP3-N6AMT2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RANBP3-N6AMT2


check button Go to

FGviewer for the breakpoints of chr19:5951404-chr13:21311944

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRANBP3chr19:5951404chr13:21311944ENST00000340578-31776_8194.0568.0Compositional biasNote=Poly-Pro
HgeneRANBP3chr19:5951404chr13:21311944ENST00000439268-31776_8194.0563.0Compositional biasNote=Poly-Pro

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRANBP3chr19:5951404chr13:21311944ENST00000034275-116537_5430500.0Compositional biasNote=Poly-Asp
HgeneRANBP3chr19:5951404chr13:21311944ENST00000034275-11676_810500.0Compositional biasNote=Poly-Pro
HgeneRANBP3chr19:5951404chr13:21311944ENST00000340578-317537_54394.0568.0Compositional biasNote=Poly-Asp
HgeneRANBP3chr19:5951404chr13:21311944ENST00000439268-317537_54394.0563.0Compositional biasNote=Poly-Asp
HgeneRANBP3chr19:5951404chr13:21311944ENST00000034275-116378_5180500.0DomainRanBD1
HgeneRANBP3chr19:5951404chr13:21311944ENST00000340578-317378_51894.0568.0DomainRanBD1
HgeneRANBP3chr19:5951404chr13:21311944ENST00000439268-317378_51894.0563.0DomainRanBD1


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Fusion Gene Sequence for RANBP3-N6AMT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000439268_ENST00000382758_TCGA-MS-A51U-01A_RANBP3_chr19_5951404_-_N6AMT2_chr13_21311944_length(transcript)=1158nt_BP=308nt
CTTGTGGGAGGGCTTAAGGAAGTAAAATGGCGGACCTGGCGAACGAAGAAAAGCCTGCCATTGCTCCGCCCGTCTTTGTGTTTCAGAAGG
ATAAAGGACAAAAGTCCCCTGCAGAGCAAAAAAACTTGTCGGATTCGGGAGAGGAGCCTCGGGGGGAGGCTGAGGCCCCCCACCATGGCA
CGGGTCACCCCGAGTCAGCTGGCGAGCATGCCCTAGAACCTCCTGCCCCTGCTGGCGCCTCAGCCAGCACTCCTCCGCCTCCCGCTCCTG
AAGCCCAGCTTCCTCCTTTTCCGCGAGAACTGGCAGGGCAACTGAGCCAGTTTTGGTATAGTCAGGAAACTGCTCTGCAGCTGGCACAGG
AGGCAATTGCAGCTGTAGGAGAAGGTGGCAGAATCGCATGTGTGAGTGCCCCTAGTGTTTACCAGAAACTCAGAGAGCTGTGCAGAGAAA
ACTTTTCGATATACATCTTTGAATATGACAAAAGATTTGCCATGTATGGAGAGGAGTTTATTTTCTATGATTACAATAATCCATTGGACT
TACCCGAAAGAATTGCTGCACATAGTTTTGACATCGTAATAGCAGATCCTCCCTATCTTTCGGAGGAATGTCTCAGAAAAACATCGGAAA
CCGTCAAGTACCTGACGCGGGGCAAGATTCTGCTGTGCACAGGTGCCATCATGGAAGAACAGGCAGCAGAACTCCTTGGAGTGAAGATGT
GCACGTTTGTTCCAAGACACACCCGGAACTTGGCAAATGAGTTTCGCTGTTATGTGAATTATGATTCTGGGCTGGACTGTGGGATCTGAT
TACAGACGGTGACATAACACAGGAAGGAACCCTGTCACATTCCTCTTTTTGTATTTTCGTAGTAGATTTAAAAGTTATAATCTCTTCCCC
TCCCCCCAAACTGGAGCTGTCCCTGGCCTGGTTTTCAAAATAAAGTGTGCGATCTTCATTATTGTTTCCTTAGGGAGGGCGTCCCTAGAG
CTCAGTCTTCTGCCAACCTGAATCCATGGAATTCGAGTTGGAAGAAACCTTAGAATCTGCCTGATCTTCTCTCCTCATTTAACATGTGTA

>In-frame_ENST00000439268_ENST00000382758_TCGA-MS-A51U-01A_RANBP3_chr19_5951404_-_N6AMT2_chr13_21311944_length(amino acids)=260AA_start in transcript=26_stop in transcript=808
MADLANEEKPAIAPPVFVFQKDKGQKSPAEQKNLSDSGEEPRGEAEAPHHGTGHPESAGEHALEPPAPAGASASTPPPPAPEAQLPPFPR
ELAGQLSQFWYSQETALQLAQEAIAAVGEGGRIACVSAPSVYQKLRELCRENFSIYIFEYDKRFAMYGEEFIFYDYNNPLDLPERIAAHS

--------------------------------------------------------------
>In-frame_ENST00000439268_ENST00000382754_TCGA-MS-A51U-01A_RANBP3_chr19_5951404_-_N6AMT2_chr13_21311944_length(transcript)=958nt_BP=308nt
CTTGTGGGAGGGCTTAAGGAAGTAAAATGGCGGACCTGGCGAACGAAGAAAAGCCTGCCATTGCTCCGCCCGTCTTTGTGTTTCAGAAGG
ATAAAGGACAAAAGTCCCCTGCAGAGCAAAAAAACTTGTCGGATTCGGGAGAGGAGCCTCGGGGGGAGGCTGAGGCCCCCCACCATGGCA
CGGGTCACCCCGAGTCAGCTGGCGAGCATGCCCTAGAACCTCCTGCCCCTGCTGGCGCCTCAGCCAGCACTCCTCCGCCTCCCGCTCCTG
AAGCCCAGCTTCCTCCTTTTCCGCGAGAACTGGCAGGGCAACTGAGCCAGTTTTGGTATAGTCAGGAAACTGCTCTGCAGCTGGCACAGG
AGGCAATTGCAGCTGTAGGAGAAGGTGGCAGAATCGCATGTGTGAGTGCCCCTAGTGTTTACCAGAAACTCAGAGAGCTGTGCAGAGAAA
ACTTTTCGATATACATCTTTGAATATGACAAAAGATTTGCCATGTATGGAGAGGAGTTTATTTTCTATGATTACAATAATCCATTGGACT
TACCCGAAAGAATTGCTGCACATAGTTTTGACATCGTAATAGCAGATCCTCCCTATCTTTCGGAGGAATGTCTCAGAAAAACATCGGAAA
CCGTCAAGTACCTGACGCGGGGCAAGATTCTGCTGTGCACAGGTGCCATCATGGAAGAACAGGCAGCAGAACTCCTTGGAGTGAAGATGT
GCACGTTTGTTCCAAGACACACCCGGAACTTGGCAAATGAGTTTCGCTGTTATGTGAATTATGATTCTGGGCTGGACTGTGGGATCTGAT
TACAGACGGTGACATAACACAGGAAGGAACCCTGTCACATTCCTCTTTTTGTATTTTCGTAGTAGATTTAAAAGTTATAATCTCTTCCCC

>In-frame_ENST00000439268_ENST00000382754_TCGA-MS-A51U-01A_RANBP3_chr19_5951404_-_N6AMT2_chr13_21311944_length(amino acids)=260AA_start in transcript=26_stop in transcript=808
MADLANEEKPAIAPPVFVFQKDKGQKSPAEQKNLSDSGEEPRGEAEAPHHGTGHPESAGEHALEPPAPAGASASTPPPPAPEAQLPPFPR
ELAGQLSQFWYSQETALQLAQEAIAAVGEGGRIACVSAPSVYQKLRELCRENFSIYIFEYDKRFAMYGEEFIFYDYNNPLDLPERIAAHS

--------------------------------------------------------------
>In-frame_ENST00000340578_ENST00000382758_TCGA-MS-A51U-01A_RANBP3_chr19_5951404_-_N6AMT2_chr13_21311944_length(transcript)=1190nt_BP=340nt
AGAAAGCAGGCGAGCCTGGGCCGGCGCGGGGCCTTGTGGGAGGGCTTAAGGAAGTAAAATGGCGGACCTGGCGAACGAAGAAAAGCCTGC
CATTGCTCCGCCCGTCTTTGTGTTTCAGAAGGATAAAGGACAAAAGTCCCCTGCAGAGCAAAAAAACTTGTCGGATTCGGGAGAGGAGCC
TCGGGGGGAGGCTGAGGCCCCCCACCATGGCACGGGTCACCCCGAGTCAGCTGGCGAGCATGCCCTAGAACCTCCTGCCCCTGCTGGCGC
CTCAGCCAGCACTCCTCCGCCTCCCGCTCCTGAAGCCCAGCTTCCTCCTTTTCCGCGAGAACTGGCAGGGCAACTGAGCCAGTTTTGGTA
TAGTCAGGAAACTGCTCTGCAGCTGGCACAGGAGGCAATTGCAGCTGTAGGAGAAGGTGGCAGAATCGCATGTGTGAGTGCCCCTAGTGT
TTACCAGAAACTCAGAGAGCTGTGCAGAGAAAACTTTTCGATATACATCTTTGAATATGACAAAAGATTTGCCATGTATGGAGAGGAGTT
TATTTTCTATGATTACAATAATCCATTGGACTTACCCGAAAGAATTGCTGCACATAGTTTTGACATCGTAATAGCAGATCCTCCCTATCT
TTCGGAGGAATGTCTCAGAAAAACATCGGAAACCGTCAAGTACCTGACGCGGGGCAAGATTCTGCTGTGCACAGGTGCCATCATGGAAGA
ACAGGCAGCAGAACTCCTTGGAGTGAAGATGTGCACGTTTGTTCCAAGACACACCCGGAACTTGGCAAATGAGTTTCGCTGTTATGTGAA
TTATGATTCTGGGCTGGACTGTGGGATCTGATTACAGACGGTGACATAACACAGGAAGGAACCCTGTCACATTCCTCTTTTTGTATTTTC
GTAGTAGATTTAAAAGTTATAATCTCTTCCCCTCCCCCCAAACTGGAGCTGTCCCTGGCCTGGTTTTCAAAATAAAGTGTGCGATCTTCA
TTATTGTTTCCTTAGGGAGGGCGTCCCTAGAGCTCAGTCTTCTGCCAACCTGAATCCATGGAATTCGAGTTGGAAGAAACCTTAGAATCT
GCCTGATCTTCTCTCCTCATTTAACATGTGTAAAAACAGAAGAACAGTTGTGTGGCTTGCCCAAGGGCTCCTGAATGAGACAGGACCTTG

>In-frame_ENST00000340578_ENST00000382758_TCGA-MS-A51U-01A_RANBP3_chr19_5951404_-_N6AMT2_chr13_21311944_length(amino acids)=260AA_start in transcript=58_stop in transcript=840
MADLANEEKPAIAPPVFVFQKDKGQKSPAEQKNLSDSGEEPRGEAEAPHHGTGHPESAGEHALEPPAPAGASASTPPPPAPEAQLPPFPR
ELAGQLSQFWYSQETALQLAQEAIAAVGEGGRIACVSAPSVYQKLRELCRENFSIYIFEYDKRFAMYGEEFIFYDYNNPLDLPERIAAHS

--------------------------------------------------------------
>In-frame_ENST00000340578_ENST00000382754_TCGA-MS-A51U-01A_RANBP3_chr19_5951404_-_N6AMT2_chr13_21311944_length(transcript)=990nt_BP=340nt
AGAAAGCAGGCGAGCCTGGGCCGGCGCGGGGCCTTGTGGGAGGGCTTAAGGAAGTAAAATGGCGGACCTGGCGAACGAAGAAAAGCCTGC
CATTGCTCCGCCCGTCTTTGTGTTTCAGAAGGATAAAGGACAAAAGTCCCCTGCAGAGCAAAAAAACTTGTCGGATTCGGGAGAGGAGCC
TCGGGGGGAGGCTGAGGCCCCCCACCATGGCACGGGTCACCCCGAGTCAGCTGGCGAGCATGCCCTAGAACCTCCTGCCCCTGCTGGCGC
CTCAGCCAGCACTCCTCCGCCTCCCGCTCCTGAAGCCCAGCTTCCTCCTTTTCCGCGAGAACTGGCAGGGCAACTGAGCCAGTTTTGGTA
TAGTCAGGAAACTGCTCTGCAGCTGGCACAGGAGGCAATTGCAGCTGTAGGAGAAGGTGGCAGAATCGCATGTGTGAGTGCCCCTAGTGT
TTACCAGAAACTCAGAGAGCTGTGCAGAGAAAACTTTTCGATATACATCTTTGAATATGACAAAAGATTTGCCATGTATGGAGAGGAGTT
TATTTTCTATGATTACAATAATCCATTGGACTTACCCGAAAGAATTGCTGCACATAGTTTTGACATCGTAATAGCAGATCCTCCCTATCT
TTCGGAGGAATGTCTCAGAAAAACATCGGAAACCGTCAAGTACCTGACGCGGGGCAAGATTCTGCTGTGCACAGGTGCCATCATGGAAGA
ACAGGCAGCAGAACTCCTTGGAGTGAAGATGTGCACGTTTGTTCCAAGACACACCCGGAACTTGGCAAATGAGTTTCGCTGTTATGTGAA
TTATGATTCTGGGCTGGACTGTGGGATCTGATTACAGACGGTGACATAACACAGGAAGGAACCCTGTCACATTCCTCTTTTTGTATTTTC
GTAGTAGATTTAAAAGTTATAATCTCTTCCCCTCCCCCCAAACTGGAGCTGTCCCTGGCCTGGTTTTCAAAATAAAGTGTGCGATCTTCA

>In-frame_ENST00000340578_ENST00000382754_TCGA-MS-A51U-01A_RANBP3_chr19_5951404_-_N6AMT2_chr13_21311944_length(amino acids)=260AA_start in transcript=58_stop in transcript=840
MADLANEEKPAIAPPVFVFQKDKGQKSPAEQKNLSDSGEEPRGEAEAPHHGTGHPESAGEHALEPPAPAGASASTPPPPAPEAQLPPFPR
ELAGQLSQFWYSQETALQLAQEAIAAVGEGGRIACVSAPSVYQKLRELCRENFSIYIFEYDKRFAMYGEEFIFYDYNNPLDLPERIAAHS

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Fusion Gene PPI Analysis for RANBP3-N6AMT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RANBP3-N6AMT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RANBP3-N6AMT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource