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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:RANBP9-TXNDC5 (FusionGDB2 ID:71651)

Fusion Gene Summary for RANBP9-TXNDC5

Fusion gene summary

Fusion gene information	Fusion gene name: RANBP9-TXNDC5
	Fusion gene ID: 71651
		Hgene	Tgene
	Gene symbol	RANBP9	TXNDC5
	Gene ID	10048	81567
	Gene name	RAN binding protein 9	thioredoxin domain containing 5
	Synonyms	BPM-L\|BPM90\|RANBPM\|RanBP7	ENDOPDI\|ERP46\|HCC-2\|HCC2\|PDIA15\|STRF8\|UNQ364
	Cytomap	6p23	6p24.3
	Type of gene	protein-coding	protein-coding
	Description	ran-binding protein 9Ran Binding Protein in the Microtubule organizing centernovel centrosomal protein RanBPMran binding protein, centrosomalran-binding protein M	thioredoxin domain-containing protein 5ER protein 46endoplasmic reticulum protein ERp46endoplasmic reticulum resident protein 46endothelial protein disulphide isomeraseepididymis secretory sperm binding proteinprotein disulfide isomerase family A, m
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000011619, ENST00000469916, ENST00000539980,	ENST00000539054, ENST00000379757, ENST00000473453,
Fusion gene scores	* DoF score	14 X 8 X 6=672	3 X 1 X 3=9
	# samples	10	3
	** MAII score	log2(10/672*10)=-2.74846123300404 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: RANBP9 [Title/Abstract] AND TXNDC5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RANBP9(13697017)-TXNDC5(7904956), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across RANBP9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TXNDC5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-HT-7604-01A	RANBP9	chr6	13697017	-	TXNDC5	chr6	7904956	-
ChimerDB4	LGG	TCGA-HT-7604	RANBP9	chr6	13697017	-	TXNDC5	chr6	7904956	-
ChimerDB4	LGG	TCGA-HT-7604-01A	RANBP9	chr6	13697017	-	TXNDC5	chr6	7904956	-

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Fusion Gene ORF analysis for RANBP9-TXNDC5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000011619	ENST00000539054	RANBP9	chr6	13697017	-	TXNDC5	chr6	7904956	-
In-frame	ENST00000011619	ENST00000379757	RANBP9	chr6	13697017	-	TXNDC5	chr6	7904956	-
5CDS-5UTR	ENST00000011619	ENST00000473453	RANBP9	chr6	13697017	-	TXNDC5	chr6	7904956	-
intron-3CDS	ENST00000469916	ENST00000539054	RANBP9	chr6	13697017	-	TXNDC5	chr6	7904956	-
intron-3CDS	ENST00000469916	ENST00000379757	RANBP9	chr6	13697017	-	TXNDC5	chr6	7904956	-
intron-5UTR	ENST00000469916	ENST00000473453	RANBP9	chr6	13697017	-	TXNDC5	chr6	7904956	-
intron-3CDS	ENST00000539980	ENST00000539054	RANBP9	chr6	13697017	-	TXNDC5	chr6	7904956	-
intron-3CDS	ENST00000539980	ENST00000379757	RANBP9	chr6	13697017	-	TXNDC5	chr6	7904956	-
intron-5UTR	ENST00000539980	ENST00000473453	RANBP9	chr6	13697017	-	TXNDC5	chr6	7904956	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000011619	RANBP9	chr6	13697017	-	ENST00000539054	TXNDC5	chr6	7904956	-	3672	742	59	1777	572
ENST00000011619	RANBP9	chr6	13697017	-	ENST00000379757	TXNDC5	chr6	7904956	-	3405	742	59	1777	572

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000011619	ENST00000539054	RANBP9	chr6	13697017	-	TXNDC5	chr6	7904956	-	0.002515447	0.99748456
ENST00000011619	ENST00000379757	RANBP9	chr6	13697017	-	TXNDC5	chr6	7904956	-	0.00444561	0.9955544

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Fusion Genomic Features for RANBP9-TXNDC5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RANBP9-TXNDC5

Go to
FGviewer for the breakpoints of chr6:13697017-chr6:7904956
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RANBP9

chr6:13697017

chr6:7904956

ENST00000011619

11_18

227.66666666666666

730.0

Compositional bias

Note=Poly-Gln

Hgene

RANBP9

chr6:13697017

chr6:7904956

ENST00000011619

21_24

227.66666666666666

730.0

Compositional bias

Note=Poly-Pro

Hgene

RANBP9

chr6:13697017

chr6:7904956

ENST00000011619

25_131

227.66666666666666

730.0

Compositional bias

Note=Ala-rich

Hgene

RANBP9

chr6:13697017

chr6:7904956

ENST00000011619

5_10

227.66666666666666

730.0

Compositional bias

Note=Poly-Pro

Hgene

RANBP9

chr6:13697017

chr6:7904956

ENST00000011619

62_66

227.66666666666666

730.0

Compositional bias

Note=Poly-Ala

Hgene

RANBP9

chr6:13697017

chr6:7904956

ENST00000011619

71_77

227.66666666666666

730.0

Compositional bias

Note=Poly-Pro

Hgene

RANBP9

chr6:13697017

chr6:7904956

ENST00000011619

82_92

227.66666666666666

730.0

Compositional bias

Note=Poly-Pro

Tgene

TXNDC5

chr6:13697017

chr6:7904956

ENST00000379757

170_295

87.66666666666667

433.0

Domain

Thioredoxin 2

Tgene

TXNDC5

chr6:13697017

chr6:7904956

ENST00000379757

304_429

87.66666666666667

433.0

Domain

Thioredoxin 3

Tgene

TXNDC5

chr6:13697017

chr6:7904956

ENST00000473453

170_295

325.0

Domain

Thioredoxin 2

Tgene

TXNDC5

chr6:13697017

chr6:7904956

ENST00000473453

304_429

325.0

Domain

Thioredoxin 3

Tgene

TXNDC5

chr6:13697017

chr6:7904956

ENST00000473453

36_169

325.0

Domain

Thioredoxin 1

Tgene

TXNDC5

chr6:13697017

chr6:7904956

ENST00000379757

429_432

87.66666666666667

433.0

Motif

Prevents secretion from ER

Tgene

TXNDC5

chr6:13697017

chr6:7904956

ENST00000473453

429_432

325.0

Motif

Prevents secretion from ER

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RANBP9

chr6:13697017

chr6:7904956

ENST00000011619

147_334

227.66666666666666

730.0

Domain

B30.2/SPRY

Hgene

RANBP9

chr6:13697017

chr6:7904956

ENST00000011619

365_397

227.66666666666666

730.0

Domain

LisH

Hgene

RANBP9

chr6:13697017

chr6:7904956

ENST00000011619

403_460

227.66666666666666

730.0

Domain

CTLH

Tgene

TXNDC5

chr6:13697017

chr6:7904956

ENST00000379757

36_169

87.66666666666667

433.0

Domain

Thioredoxin 1

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Fusion Gene Sequence for RANBP9-TXNDC5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000011619_ENST00000539054_TCGA-HT-7604-01A_RANBP9_chr6_13697017_-_TXNDC5_chr6_7904956_length(transcript)=3672nt_BP=742nt
GAAGCAGAGGAGGAAGGAGAGAAGAGGTGGAGGTGGCCGCAGGCTGAGTCGCGGCCGGGATGTCCGGGCAGCCGCCGCCGCCGCCGCCGC
AGCAGCAGCAACAGCAGCAGCAGCTGTCGCCGCCACCGCCGGCGGCCTTGGCCCCAGTCTCCGGAGTCGTCCTGCCGGCGCCCCCGGCCG
TCAGCGCCGGCTCTTCTCCGGCCGGCTCGCCCGGCGGCGGTGCGGGCGGCGAAGGCTTAGGGGCCGCGGCGGCCGCCCTGCTCCTCCACC
CTCCGCCGCCGCCGCCCCCGGCCACCGCGGCCCCGCCGCCCCCGCCGCCGCCCCCGCCTCCCCCTGCCTCAGCGGCTGCCCCCGCCAGCG
GGCCGCCCGCTCCCCCGGGCCTTGCAGCGGGCCCCGGCCCGGCTGGAGGAGCCCCGACCCCAGCTCTGGTGGCGGGCAGCAGCGCCGCGG
CCCCCTTCCCTCACGGGGACTCGGCCCTGAACGAGCAGGAGAAGGAGTTGCAGCGGCGGCTGAAGCGTCTCTACCCGGCCGTGGACGAAC
AAGAGACGCCGCTGCCTCGGTCCTGGAGCCCGAAGGACAAGTTCAGCTACATCGGCCTCTCTCAGAACAACCTGCGGGTGCACTACAAAG
GTCATGGCAAAACCCCAAAAGATGCCGCGTCAGTTCGAGCCACGCATCCAATACCAGCAGCCTGTGGGATTTATTATTTTGAAGTAAAAA
TTGTCAGTAAGGGAAGAGATGGGTGTGGACACTGCCAGCGGCTGCAGCCGACTTGGAATGACCTGGGAGACAAATACAACAGCATGGAAG
ATGCCAAAGTCTATGTGGCTAAAGTGGACTGCACGGCCCACTCCGACGTGTGCTCCGCCCAGGGGGTGCGAGGATACCCCACCTTAAAGC
TTTTCAAGCCAGGCCAAGAAGCTGTGAAGTACCAGGGTCCTCGGGACTTCCAGACACTGGAAAACTGGATGCTGCAGACACTGAACGAGG
AGCCAGTGACACCAGAGCCGGAAGTGGAACCGCCCAGTGCCCCCGAGCTCAAGCAAGGGCTGTATGAGCTCTCAGCAAGCAACTTTGAGC
TGCACGTTGCACAAGGCGACCACTTTATCAAGTTCTTCGCTCCGTGGTGTGGTCACTGCAAAGCCCTGGCTCCAACCTGGGAGCAGCTGG
CTCTGGGCCTTGAACATTCCGAAACTGTCAAGATTGGCAAGGTTGATTGTACACAGCACTATGAACTCTGCTCCGGAAACCAGGTTCGTG
GCTATCCCACTCTTCTCTGGTTCCGAGATGGGAAAAAGGTGGATCAGTACAAGGGAAAGCGGGATTTGGAGTCACTGAGGGAGTACGTGG
AGTCGCAGCTGCAGCGCACAGAGACTGGAGCGACGGAGACCGTCACGCCCTCAGAGGCCCCGGTGCTGGCAGCTGAGCCCGAGGCTGACA
AGGGCACTGTGTTGGCACTCACTGAAAATAACTTCGATGACACCATTGCAGAAGGAATAACCTTCATCAAGTTTTATGCTCCATGGTGTG
GTCATTGTAAGACTCTGGCTCCTACTTGGGAGGAACTCTCTAAAAAGGAATTCCCTGGTCTGGCGGGGGTCAAGATCGCCGAAGTAGACT
GCACTGCTGAACGGAATATCTGCAGCAAGTATTCGGTACGAGGCTACCCCACGTTATTGCTTTTCCGAGGAGGGAAGAAAGTCAGTGAGC
ACAGTGGAGGCAGAGACCTTGACTCGTTACACCGCTTTGTCCTGAGCCAAGCGAAAGACGAACTTTAGGAACACAGTTGGAGGTCACCTC
TCCTGCCCAGCTCCCGCACCCTGCGTTTAGGAGTTCAGTCCCACAGAGGCCACTGGGTTCCCAGTGGTGGCTGTTCAGAAAGCAGAACAT
ACTAAGCGTGAGGTATCTTCTTTGTGTGTGTGTTTTCCAAGCCAACACACTCTACAGATTCTTTATTAAGTTAAGTTTCTCTAAGTAAAT
GTGTAACTCATGGTCACTGTGTAAACATTTTCAGTGGCGATATATCCCCTTTGACCTTCTCTTGATGAAATTTACATGGTTTCCTTTGAG
ACTAAAATAGCGTTGAGGGAAATGAAATTGCTGGACTATTTGTGGCTCCTGAGTTGAGTGATTTTGGTGAAAGAAAGCACATCCAAAGCA
TAGTTTACCTGCCCACGAGTTCTGGAAAGGTGGCCTTGTGGCAGTATTGACGTTCCTCTGATCTTAAGGTCACAGTTGACTCAATACTGT
GTTGGTCCGTAGCATGGAGCAGATTGAAATGCAAAAACCCACACCTCTGGAAGATACCTTCACGGCCGCTGCTGGAGCTTCTGTTGCTGT
GAATACTTCTCTCAGTGTGAGAGGTTAGCCGTGATGAAAGCAGCGTTACTTCTGACCGTGCCTGAGTAAGAGAATGCTGATGCCATAACT
TTATGTGTCGATACTTGTCAAATCAGTTACTGTTCAGGGGATCCTTCTGTTTCTCACGGGGTGAAACATGTCTTTAGTTCCTCATGTTAA
CACGAAGCCAGAGCCCACATGAACTGTTGGATGTCTTCCTTAGAAAGGGTAGGCATGGAAAATTCCACGAGGCTCATTCTCAGTATCTCA
TTAACTCATTGAAAGATTCCAGTTGTATTTGTCACCTGGGGTGACAAGACCAGACAGGCTTTCCCAGGCCTGGGTATCCAGGGAGGCTCT
GCAGCCCTGCTGAAGGGCCCTAACTAGAGTTCTAGAGTTTCTGATTCTGTTTCTCAGTAGTCCTTTTAGAGGCTTGCTATACTTGGTCTG
CTTCAAGGAGGTCGACCTTCTAATGTATGAAGAATGGGATGCATTTGATCTCAAGACCAAAGACAGATGTCAGTGGGCTGCTCTGGCCCT
GGTGTGCACGGCTGTGGCAGCTGTTGATGCCAGTGTCCTCTAACTCATGCTGTCCTTGTGATTAAACACCTCTATCTCCCTTGGGAATAA
GCACATACAGGCTTAAGCTCTAAGATAGATAGGTGTTTGTCCTTTTACCATCGAGCTACTTCCCATAATAACCACTTTGCATCCAACACT
CTTCACCCACCTCCCATACGCAAGGGGATGTGGATACTTGGCCCAAAGTAACTGGTGGTAGGAATCTTAGAAACAAGACCACTTATACTG
TCTGTCTGAGGCAGAAGATAACAGCAGCATCTCGACCAGCCTCTGCCTTAAAGGAAATCTTTATTAATCACGTATGGTTCACAGATAATT
CTTTTTTTAAAAAAACCCAACCTCCTAGAGAAGCACAACTGTCAAGAGTCTTGTACACACAACTTCAGCTTTGCATCACGAGTCTTGTAT
TCCAAGAAAATCAAAGTGGTACAATTTGTTTGTTTACACTATGATACTTTCTAAATAAACTCTTTTTTTTTAAAAGTCTGGTCTTTCCTT
CAATGTTACAGCAAAACAGATATAAAATAGACAATAAATTATAGTTTATATTTACAAAAAAAGCTGTAAGTGCAAACAGTTGTAGATTAT
AAATGTATTATTTAATCAGTTTAGTATGAAATTGCCTTCCCAGTACATGATTGTGAAAAAGACATTTAGAAAATATTCTAAAATTTAATC

>In-frame_ENST00000011619_ENST00000539054_TCGA-HT-7604-01A_RANBP9_chr6_13697017_-_TXNDC5_chr6_7904956_length(amino acids)=572AA_start in transcript=59_stop in transcript=1777
MSGQPPPPPPQQQQQQQQLSPPPPAALAPVSGVVLPAPPAVSAGSSPAGSPGGGAGGEGLGAAAAALLLHPPPPPPPATAAPPPPPPPPP
PPASAAAPASGPPAPPGLAAGPGPAGGAPTPALVAGSSAAAPFPHGDSALNEQEKELQRRLKRLYPAVDEQETPLPRSWSPKDKFSYIGL
SQNNLRVHYKGHGKTPKDAASVRATHPIPAACGIYYFEVKIVSKGRDGCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSA
QGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHC
KALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEA
PVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLL

--------------------------------------------------------------
>In-frame_ENST00000011619_ENST00000379757_TCGA-HT-7604-01A_RANBP9_chr6_13697017_-_TXNDC5_chr6_7904956_length(transcript)=3405nt_BP=742nt
GAAGCAGAGGAGGAAGGAGAGAAGAGGTGGAGGTGGCCGCAGGCTGAGTCGCGGCCGGGATGTCCGGGCAGCCGCCGCCGCCGCCGCCGC
AGCAGCAGCAACAGCAGCAGCAGCTGTCGCCGCCACCGCCGGCGGCCTTGGCCCCAGTCTCCGGAGTCGTCCTGCCGGCGCCCCCGGCCG
TCAGCGCCGGCTCTTCTCCGGCCGGCTCGCCCGGCGGCGGTGCGGGCGGCGAAGGCTTAGGGGCCGCGGCGGCCGCCCTGCTCCTCCACC
CTCCGCCGCCGCCGCCCCCGGCCACCGCGGCCCCGCCGCCCCCGCCGCCGCCCCCGCCTCCCCCTGCCTCAGCGGCTGCCCCCGCCAGCG
GGCCGCCCGCTCCCCCGGGCCTTGCAGCGGGCCCCGGCCCGGCTGGAGGAGCCCCGACCCCAGCTCTGGTGGCGGGCAGCAGCGCCGCGG
CCCCCTTCCCTCACGGGGACTCGGCCCTGAACGAGCAGGAGAAGGAGTTGCAGCGGCGGCTGAAGCGTCTCTACCCGGCCGTGGACGAAC
AAGAGACGCCGCTGCCTCGGTCCTGGAGCCCGAAGGACAAGTTCAGCTACATCGGCCTCTCTCAGAACAACCTGCGGGTGCACTACAAAG
GTCATGGCAAAACCCCAAAAGATGCCGCGTCAGTTCGAGCCACGCATCCAATACCAGCAGCCTGTGGGATTTATTATTTTGAAGTAAAAA
TTGTCAGTAAGGGAAGAGATGGGTGTGGACACTGCCAGCGGCTGCAGCCGACTTGGAATGACCTGGGAGACAAATACAACAGCATGGAAG
ATGCCAAAGTCTATGTGGCTAAAGTGGACTGCACGGCCCACTCCGACGTGTGCTCCGCCCAGGGGGTGCGAGGATACCCCACCTTAAAGC
TTTTCAAGCCAGGCCAAGAAGCTGTGAAGTACCAGGGTCCTCGGGACTTCCAGACACTGGAAAACTGGATGCTGCAGACACTGAACGAGG
AGCCAGTGACACCAGAGCCGGAAGTGGAACCGCCCAGTGCCCCCGAGCTCAAGCAAGGGCTGTATGAGCTCTCAGCAAGCAACTTTGAGC
TGCACGTTGCACAAGGCGACCACTTTATCAAGTTCTTCGCTCCGTGGTGTGGTCACTGCAAAGCCCTGGCTCCAACCTGGGAGCAGCTGG
CTCTGGGCCTTGAACATTCCGAAACTGTCAAGATTGGCAAGGTTGATTGTACACAGCACTATGAACTCTGCTCCGGAAACCAGGTTCGTG
GCTATCCCACTCTTCTCTGGTTCCGAGATGGGAAAAAGGTGGATCAGTACAAGGGAAAGCGGGATTTGGAGTCACTGAGGGAGTACGTGG
AGTCGCAGCTGCAGCGCACAGAGACTGGAGCGACGGAGACCGTCACGCCCTCAGAGGCCCCGGTGCTGGCAGCTGAGCCCGAGGCTGACA
AGGGCACTGTGTTGGCACTCACTGAAAATAACTTCGATGACACCATTGCAGAAGGAATAACCTTCATCAAGTTTTATGCTCCATGGTGTG
GTCATTGTAAGACTCTGGCTCCTACTTGGGAGGAACTCTCTAAAAAGGAATTCCCTGGTCTGGCGGGGGTCAAGATCGCCGAAGTAGACT
GCACTGCTGAACGGAATATCTGCAGCAAGTATTCGGTACGAGGCTACCCCACGTTATTGCTTTTCCGAGGAGGGAAGAAAGTCAGTGAGC
ACAGTGGAGGCAGAGACCTTGACTCGTTACACCGCTTTGTCCTGAGCCAAGCGAAAGACGAACTTTAGGAACACAGTTGGAGGTCACCTC
TCCTGCCCAGCTCCCGCACCCTGCGTTTAGGAGTTCAGTCCCACAGAGGCCACTGGGTTCCCAGTGGTGGCTGTTCAGAAAGCAGAACAT
ACTAAGCGTGAGGTATCTTCTTTGTGTGTGTGTTTTCCAAGCCAACACACTCTACAGATTCTTTATTAAGTTAAGTTTCTCTAAGTAAAT
GTGTAACTCATGGTCACTGTGTAAACATTTTCAGTGGCGATATATCCCCTTTGACCTTCTCTTGATGAAATTTACATGGTTTCCTTTGAG
ACTAAAATAGCGTTGAGGGAAATGAAATTGCTGGACTATTTGTGGCTCCTGAGTTGAGTGATTTTGGTGAAAGAAAGCACATCCAAAGCA
TAGTTTACCTGCCCACGAGTTCTGGAAAGGTGGCCTTGTGGCAGTATTGACGTTCCTCTGATCTTAAGGTCACAGTTGACTCAATACTGT
GTTGGTCCGTAGCATGGAGCAGATTGAAATGCAAAAACCCACACCTCTGGAAGATACCTTCACGGCCGCTGCTGGAGCTTCTGTTGCTGT
GAATACTTCTCTCAGTGTGAGAGGTTAGCCGTGATGAAAGCAGCGTTACTTCTGACCGTGCCTGAGTAAGAGAATGCTGATGCCATAACT
TTATGTGTCGATACTTGTCAAATCAGTTACTGTTCAGGGGATCCTTCTGTTTCTCACGGGGTGAAACATGTCTTTAGTTCCTCATGTTAA
CACGAAGCCAGAGCCCACATGAACTGTTGGATGTCTTCCTTAGAAAGGGTAGGCATGGAAAATTCCACGAGGCTCATTCTCAGTATCTCA
TTAACTCATTGAAAGATTCCAGTTGTATTTGTCACCTGGGGTGACAAGACCAGACAGGCTTTCCCAGGCCTGGGTATCCAGGGAGGCTCT
GCAGCCCTGCTGAAGGGCCCTAACTAGAGTTCTAGAGTTTCTGATTCTGTTTCTCAGTAGTCCTTTTAGAGGCTTGCTATACTTGGTCTG
CTTCAAGGAGGTCGACCTTCTAATGTATGAAGAATGGGATGCATTTGATCTCAAGACCAAAGACAGATGTCAGTGGGCTGCTCTGGCCCT
GGTGTGCACGGCTGTGGCAGCTGTTGATGCCAGTGTCCTCTAACTCATGCTGTCCTTGTGATTAAACACCTCTATCTCCCTTGGGAATAA
GCACATACAGGCTTAAGCTCTAAGATAGATAGGTGTTTGTCCTTTTACCATCGAGCTACTTCCCATAATAACCACTTTGCATCCAACACT
CTTCACCCACCTCCCATACGCAAGGGGATGTGGATACTTGGCCCAAAGTAACTGGTGGTAGGAATCTTAGAAACAAGACCACTTATACTG
TCTGTCTGAGGCAGAAGATAACAGCAGCATCTCGACCAGCCTCTGCCTTAAAGGAAATCTTTATTAATCACGTATGGTTCACAGATAATT
CTTTTTTTAAAAAAACCCAACCTCCTAGAGAAGCACAACTGTCAAGAGTCTTGTACACACAACTTCAGCTTTGCATCACGAGTCTTGTAT

>In-frame_ENST00000011619_ENST00000379757_TCGA-HT-7604-01A_RANBP9_chr6_13697017_-_TXNDC5_chr6_7904956_length(amino acids)=572AA_start in transcript=59_stop in transcript=1777
MSGQPPPPPPQQQQQQQQLSPPPPAALAPVSGVVLPAPPAVSAGSSPAGSPGGGAGGEGLGAAAAALLLHPPPPPPPATAAPPPPPPPPP
PPASAAAPASGPPAPPGLAAGPGPAGGAPTPALVAGSSAAAPFPHGDSALNEQEKELQRRLKRLYPAVDEQETPLPRSWSPKDKFSYIGL
SQNNLRVHYKGHGKTPKDAASVRATHPIPAACGIYYFEVKIVSKGRDGCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSA
QGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHC
KALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEA
PVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLL

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Fusion Gene PPI Analysis for RANBP9-TXNDC5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	RANBP9	chr6:13697017	chr6:7904956	ENST00000011619	-	2	14	401_407	227.66666666666666	730.0	CALB1
Hgene	RANBP9	chr6:13697017	chr6:7904956	ENST00000011619	-	2	14	615_729	227.66666666666666	730.0	FMR1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for RANBP9-TXNDC5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for RANBP9-TXNDC5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	RANBP9	C0036341	Schizophrenia	1	PSYGENET
Tgene	TXNDC5	C0003865	Arthritis, Adjuvant-Induced	1	CTD_human
Tgene	TXNDC5	C0003873	Rheumatoid Arthritis	1	CTD_human
Tgene	TXNDC5	C0027627	Neoplasm Metastasis	1	CTD_human
Tgene	TXNDC5	C0033578	Prostatic Neoplasms	1	CTD_human
Tgene	TXNDC5	C0036341	Schizophrenia	1	PSYGENET
Tgene	TXNDC5	C0376358	Malignant neoplasm of prostate	1	CTD_human
Tgene	TXNDC5	C0971858	Arthritis, Collagen-Induced	1	CTD_human
Tgene	TXNDC5	C0993582	Arthritis, Experimental	1	CTD_human