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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RASAL2-GALNTL6 (FusionGDB2 ID:71966)

Fusion Gene Summary for RASAL2-GALNTL6

check button Fusion gene summary
Fusion gene informationFusion gene name: RASAL2-GALNTL6
Fusion gene ID: 71966
HgeneTgene
Gene symbol

RASAL2

GALNTL6

Gene ID

9462

442117

Gene nameRAS protein activator like 2polypeptide N-acetylgalactosaminyltransferase like 6
SynonymsNGAPGALNACT20|GALNT17|GalNAc-T6L
Cytomap

1q25.2

4q34.1

Type of geneprotein-codingprotein-coding
Descriptionras GTPase-activating protein nGAPRASAL2/ACVR1 fusionRas protein activator like 1polypeptide N-acetylgalactosaminyltransferase-like 6GaNTase 17GalNAc transferase 17UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 17UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 20UDP-N-acetyl-alpha-D-gala
Modification date2020031320200313
UniProtAcc.

Q49A17

Ensembl transtripts involved in fusion geneENST00000448150, ENST00000367649, 
ENST00000465723, ENST00000462775, 
ENST00000506823, ENST00000508122, 
ENST00000457021, ENST00000511251, 
Fusion gene scores* DoF score19 X 13 X 10=247016 X 15 X 8=1920
# samples 2018
** MAII scorelog2(20/2470*10)=-3.62643913669732
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1920*10)=-3.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RASAL2 [Title/Abstract] AND GALNTL6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRASAL2(178269253)-GALNTL6(173730512), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGALNTL6

GO:0018243

protein O-linked glycosylation via threonine

22186971


check buttonFusion gene breakpoints across RASAL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GALNTL6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-78-8640-01ARASAL2chr1

178269253

+GALNTL6chr4

173730512

+
ChimerDB4LUADTCGA-78-8640-01ARASAL2chr1

178269253

+GALNTL6chr4

173730512

+
ChimerDB4LUADTCGA-78-8640-01ARASAL2chr1

178269253

-GALNTL6chr4

173730512

+


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Fusion Gene ORF analysis for RASAL2-GALNTL6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000448150ENST00000506823RASAL2chr1

178269253

+GALNTL6chr4

173730512

+
In-frameENST00000448150ENST00000508122RASAL2chr1

178269253

+GALNTL6chr4

173730512

+
5CDS-intronENST00000448150ENST00000457021RASAL2chr1

178269253

+GALNTL6chr4

173730512

+
5CDS-intronENST00000448150ENST00000511251RASAL2chr1

178269253

+GALNTL6chr4

173730512

+
In-frameENST00000367649ENST00000506823RASAL2chr1

178269253

+GALNTL6chr4

173730512

+
In-frameENST00000367649ENST00000508122RASAL2chr1

178269253

+GALNTL6chr4

173730512

+
5CDS-intronENST00000367649ENST00000457021RASAL2chr1

178269253

+GALNTL6chr4

173730512

+
5CDS-intronENST00000367649ENST00000511251RASAL2chr1

178269253

+GALNTL6chr4

173730512

+
intron-3CDSENST00000465723ENST00000506823RASAL2chr1

178269253

+GALNTL6chr4

173730512

+
intron-3CDSENST00000465723ENST00000508122RASAL2chr1

178269253

+GALNTL6chr4

173730512

+
intron-intronENST00000465723ENST00000457021RASAL2chr1

178269253

+GALNTL6chr4

173730512

+
intron-intronENST00000465723ENST00000511251RASAL2chr1

178269253

+GALNTL6chr4

173730512

+
intron-3CDSENST00000462775ENST00000506823RASAL2chr1

178269253

+GALNTL6chr4

173730512

+
intron-3CDSENST00000462775ENST00000508122RASAL2chr1

178269253

+GALNTL6chr4

173730512

+
intron-intronENST00000462775ENST00000457021RASAL2chr1

178269253

+GALNTL6chr4

173730512

+
intron-intronENST00000462775ENST00000511251RASAL2chr1

178269253

+GALNTL6chr4

173730512

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000448150RASAL2chr1178269253+ENST00000506823GALNTL6chr4173730512+393312214102473687
ENST00000448150RASAL2chr1178269253+ENST00000508122GALNTL6chr4173730512+247412214102473688
ENST00000367649RASAL2chr1178269253+ENST00000506823GALNTL6chr4173730512+35218091662061631
ENST00000367649RASAL2chr1178269253+ENST00000508122GALNTL6chr4173730512+20628091662061632

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000448150ENST00000506823RASAL2chr1178269253+GALNTL6chr4173730512+0.002183930.9978161
ENST00000448150ENST00000508122RASAL2chr1178269253+GALNTL6chr4173730512+0.0108446370.98915535
ENST00000367649ENST00000506823RASAL2chr1178269253+GALNTL6chr4173730512+0.001210740.99878925
ENST00000367649ENST00000508122RASAL2chr1178269253+GALNTL6chr4173730512+0.0052043860.9947956

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Fusion Genomic Features for RASAL2-GALNTL6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RASAL2chr1178269253+GALNTL6chr4173730511+3.59E-081
RASAL2chr1178269253+GALNTL6chr4173730511+3.59E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RASAL2-GALNTL6


check button Go to

FGviewer for the breakpoints of chr1:178269253-chr4:173730512

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GALNTL6

Q49A17

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGALNTL6chr1:178269253chr4:173730512ENST00000506823413453_585184.33333333333334602.0DomainRicin B-type lectin
TgeneGALNTL6chr1:178269253chr4:173730512ENST00000508122312453_585167.33333333333334585.0DomainRicin B-type lectin
TgeneGALNTL6chr1:178269253chr4:173730512ENST00000506823413306_368184.33333333333334602.0RegionNote=Catalytic subdomain B
TgeneGALNTL6chr1:178269253chr4:173730512ENST00000508122312306_368167.33333333333334585.0RegionNote=Catalytic subdomain B

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRASAL2chr1:178269253chr4:173730512ENST00000367649+318237_243152.333333333333341281.0Compositional biasNote=Poly-Lys
HgeneRASAL2chr1:178269253chr4:173730512ENST00000367649+318922_925152.333333333333341281.0Compositional biasNote=Poly-Ser
HgeneRASAL2chr1:178269253chr4:173730512ENST00000462775+116237_24301140.0Compositional biasNote=Poly-Lys
HgeneRASAL2chr1:178269253chr4:173730512ENST00000462775+116922_92501140.0Compositional biasNote=Poly-Ser
HgeneRASAL2chr1:178269253chr4:173730512ENST00000367649+318149_267152.333333333333341281.0DomainC2
HgeneRASAL2chr1:178269253chr4:173730512ENST00000367649+318327_519152.333333333333341281.0DomainRas-GAP
HgeneRASAL2chr1:178269253chr4:173730512ENST00000367649+31841_158152.333333333333341281.0DomainNote=PH
HgeneRASAL2chr1:178269253chr4:173730512ENST00000462775+116149_26701140.0DomainC2
HgeneRASAL2chr1:178269253chr4:173730512ENST00000462775+116327_51901140.0DomainRas-GAP
HgeneRASAL2chr1:178269253chr4:173730512ENST00000462775+11641_15801140.0DomainNote=PH
TgeneGALNTL6chr1:178269253chr4:173730512ENST00000506823413139_248184.33333333333334602.0RegionNote=Catalytic subdomain A
TgeneGALNTL6chr1:178269253chr4:173730512ENST00000508122312139_248167.33333333333334585.0RegionNote=Catalytic subdomain A
TgeneGALNTL6chr1:178269253chr4:173730512ENST000005068234131_7184.33333333333334602.0Topological domainCytoplasmic
TgeneGALNTL6chr1:178269253chr4:173730512ENST0000050682341329_601184.33333333333334602.0Topological domainLumenal
TgeneGALNTL6chr1:178269253chr4:173730512ENST000005081223121_7167.33333333333334585.0Topological domainCytoplasmic
TgeneGALNTL6chr1:178269253chr4:173730512ENST0000050812231229_601167.33333333333334585.0Topological domainLumenal
TgeneGALNTL6chr1:178269253chr4:173730512ENST000005068234138_28184.33333333333334602.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneGALNTL6chr1:178269253chr4:173730512ENST000005081223128_28167.33333333333334585.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for RASAL2-GALNTL6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000448150_ENST00000506823_TCGA-78-8640-01A_RASAL2_chr1_178269253_+_GALNTL6_chr4_173730512_length(transcript)=3933nt_BP=1221nt
CCCTCGATTGCTTCAGCCTATCACCCTGGGATGCCGCCTGCCGCTGCCGCCGCCGCCGCCGCCGCCACCGCCACCGCCACCGCCACCGCC
ACCGCCGTGGCTGCCGGGTTTGTGGGATCCGCCGCGGAGCAGGAGCCAGAGCTGTGGCCGGAGCTGTGGCCTGAGAGTCAGGGGGCGGGC
AGGCTCATTCCAGAAGTGGGGGCCGAGGACAGGCGGGCTAGAACCCGGGGCCACCGCCCCCTACCCCTCCTCAGGCTGAGGGAACGGGCA
CTCGGAGCTTCTGAGGCGGCGGCGGCGGGAGCCGGTCAGAGGGGGCGGCCCCTGGCGGCGACGCCCCCAAGCCCAGCCCTGCCCGGCCCC
GCTCCATCCCCAGCCAGAGCCTGGTCTGACCGCGAGAGACGCCGGCGGGGCTGAAGAAGGCGGCTCCGAGGAGGTGGGAGGGCGAGCCTC
CCCTCCCGGGTTCTTCTGCGTCCTCTCCCGGGAGGGACCCACACACACCTGAGCCCGGACCCACCCTTGGTCGGGGCCACGCTGGATCCT
CCTCCCGGCCTGGGTCCCGCCCGCCGACTGCAGGTGGGCTGCATCGCCCGAGCCTCGGGCAGTGGGCGACGGGGAAGGAGGTGAGAGGTG
TCCGCGCCGGCTGCCGCTCGGGTCCCTGCCCTCGCTGCGCGCTCTCCTCCTCCCCTTACCGCAGGCAGGGCGCGGAGCCGCGCGCCAGCC
CGCCCCGAAGCCGCCGCCTCGTCCCCCTCCCGCCTCGGGGCACCATGGAGCTCTCTCCGTCGTCCGGAGGAGCCGCGGAGGCGCTGTCCT
GGCCGGAGATGTTCCCGGCGCTGGAGTCCGACTCGCCGCTGCCCCCGGAGGACCTGGACGCGGTTGTCCCAGTCAGTGGAGCCGTCGCCG
GTGGCATGTTGGATCGGATCCTTCTGGAGTCCGTGTGCCAGCAACAGAGCTGGGTCCGGGTGTACGATGTGAAAGGACCACCCACCCACC
GTCTGTCTTGTGGTCAGTCACCCTACACCGAGACAACAACGTGGGAGCGGAAGTATTGCATCCTCACAGACAGCCAGTTGGTATTGCTCA
ACAAGGAGAAGGAGATACCTGTGGAAGGGGGACAGGAGCAGCAGACAGATTCCACCAAAGGGCGATGCCTGAGGAGAACTGTCAGTGTCC
CTTCCGAGGGTCAGTTTCCCGAGTACCCACCAGAGGGCGCCACTAAACTGGAACACCTGAAGGATAAATTGGAAGAATACATGGCCCGAT
TTTCCAAAGTGAGGATTGTTCGCACCAAGAAAAGAGAAGGACTCATCCGGACCCGTCTCCTGGGGGCATCTATGGCCAGAGGAGAAGTCC
TGACATTCCTGGACTCCCACTGCGAGGTCAATGTGAACTGGCTGCCCCCACTCCTCAACCAAATTGCACTAAACCACAAAACCATCGTGT
GTCCCATGATCGATGTCATTGACCACAATCACTTCGGGTATGAGGCACAAGCTGGGGATGCCATGCGAGGAGCCTTCGACTGGGAAATGT
ACTACAAAAGAATCCCCATCCCTCCAGAGCTCCAGAGGGCAGATCCCAGCGACCCTTTTGAGTCTCCTGTTATGGCTGGAGGTCTCTTTG
CTGTGGATCGGAAATGGTTTTGGGAATTGGGTGGCTATGATCCAGGTTTAGAAATCTGGGGAGGAGAACAGTATGAAATCTCTTTTAAGG
TTTGGATGTGTGGAGGAGAAATGTTTGATGTTCCATGTTCTAGAGTTGGTCATATCTACAGGAAGTACGTTCCATACAAAGTTCCATCTG
GGACAAGCCTGGCAAGAAACCTGAAGCGGGTAGCTGAGACCTGGATGGATGAATTTGCCGAGTACATTTACCAGCGGCGGCCGGAGTACA
GGCATCTCTCCACGGGGGACATCTCTGCCCAGAAGGAGCTGCGCAAGCAGCTCAAGTGCAAGGACTTCAAATGGTTCATGGCTGCTGTGG
CCTGGGACGTGCCTAAATACTACCCTCCAGTGGAGCCCCCGCCTGCTGCCTGGGGGGAGATCCGAAATGTGGCAGCAAATCTCTGTGTGG
ACAGCAAGCATGGAGCCACCGGAACAGAGCTGAGGCTGGACATCTGTGTCAAGGATGGTTCTGAAAGAACATGGTCTCATGAACAGCTTT
TTACCTTTGGATGGAGAGAAGATATTCGACCCGGTGAGCCACTGCATACCCGGAAATTCTGCTTTGATGCGATCTCACACAACAGCCCCG
TTACACTCTATGACTGTCATGGCATGAAGGGGAACCAGCTCTGGGGATACCGGAAGGACAGAACATTATTCCATCCTGTGAGCAACAGCT
GCATGGATTGCAACCCCGCAGAGAAGAAGATTTTCATGGCCAGATGTGACCCTCTCTCTGAGACTCAGCAGTGGATTTTTGAACACATTA
ATATGACTGTTTTAGAAAAATTTAACCACCATGCCAACTCCTAGAAAGAAGAAAGGAAGAAAGAGTGATTACCTACAGGTTATAAATTAA
ATTTTAGCCAGCATCTGGGTCGAAGGAGTCAGGAATAACATTTCCTCGATCCAGGAAGGCTGGTTTAAAAATTTGCAAATGCCATGTCAA
AGTAGGTTGTTTTGAAGAACTTCCTGCATCTGAAGAACTTGGCTGAGAATCTCACCAGCTGCTTCTGAGAACTCGAGACTAGCAGTTCCC
TTGCTGGCCAAGGGCAAAGATAATTTAGGGACTTTTCAAAACAACTGCTGAGCTAATAAATCCTAGCATTTCTCAGGTCAAATCCTGCAG
TAGTGAGTAGCTATGAATGGATCCTATTAACTGGGTGGGAGGGGGGTGAAAATGGAGTGCATGACTGCTCTGACAACCTGAGGATATCAC
AGGTTTAGAACTAGCCAAGCTTAAGGGGTGAGCTGTACTCTTTGGTGCCATTCTCTGACTAAGAATGGGTTCAGCAGGTTTAACCCTTAA
AAGTGCTGCAGATGATTTCAGAGTGCTCACACTATTCTGTTTTTTTTATTTTTATTTTTAAATGAGGGTGCAATATCTAATGTAAGACTT
AAATTACATAATGAAATGGACATCCAGTGTTCCCATTCTTTCGTTTATATTTGCCATTTTTTTTTCAGAGCAAAGTTTCTTTTTTATGAA
AGTTCATGCTCCATGAATCCACTGAATTTCTAATTCAGTGCCCTTCTATGAATCCAGTTAAAAACAAAAGCAAAAGCAAAAATCTATGCT
ATCAAGTTACTCCAAAGAAAGATTTCACAGAAGCAGCAAAACCATATAAGATTTAGGAGAGGGACTTCCCTGGGAAATCTATTTTTACTT
TTCTATTATTTTTAAAATCTTAAAAGTCTGATATTTGTCCAGTCATAATTTTTATTAAGCAAGGAAATGGAGTGAGTTTGATGTAATTTG
TTTAGGAGATTCTTAAACCCAAATAAATCTACACTCCAAGTGATATGTGAAAATGGCTTAGTTCACTTCAATTCTGTTTAGTCAGTGGTG
GGAGCTTAGAAGTGGTTTTATTTGTTCGTTTGTTTGGGTTTTGCTTTTGTTTTTTATTTTTTTCTTGTTTTTTTTTTGTAGTGTTGAATT
AATGATGTTCTTTTATTTGGAAGCTCATAAAAGGAATTACCATTAATAAAGTGTTTCTGACACCATTTTCTGTTAATGGGACAATATTTC
GGGGATGAAGAAAGGAATGCTCCGAAAACTAAATGGAACACTTAATCCTTAAAGCAATTTTTTACTGTTCAATAATATCACATTGGGGGA
AGAAAACACAGGTATCAAGGTGGTTCTTGGGAAAAAAGAATCATGTTTATTATATATCTCTCAAGTTTTTTTGGTATAAAAATGTTTTAA

>In-frame_ENST00000448150_ENST00000506823_TCGA-78-8640-01A_RASAL2_chr1_178269253_+_GALNTL6_chr4_173730512_length(amino acids)=687AA_start in transcript=410_stop in transcript=2473
MKKAAPRRWEGEPPLPGSSASSPGRDPHTPEPGPTLGRGHAGSSSRPGSRPPTAGGLHRPSLGQWATGKEVRGVRAGCRSGPCPRCALSS
SPYRRQGAEPRASPPRSRRLVPLPPRGTMELSPSSGGAAEALSWPEMFPALESDSPLPPEDLDAVVPVSGAVAGGMLDRILLESVCQQQS
WVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKL
EHLKDKLEEYMARFSKVRIVRTKKREGLIRTRLLGASMARGEVLTFLDSHCEVNVNWLPPLLNQIALNHKTIVCPMIDVIDHNHFGYEAQ
AGDAMRGAFDWEMYYKRIPIPPELQRADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGEMFDVPCSRVG
HIYRKYVPYKVPSGTSLARNLKRVAETWMDEFAEYIYQRRPEYRHLSTGDISAQKELRKQLKCKDFKWFMAAVAWDVPKYYPPVEPPPAA
WGEIRNVAANLCVDSKHGATGTELRLDICVKDGSERTWSHEQLFTFGWREDIRPGEPLHTRKFCFDAISHNSPVTLYDCHGMKGNQLWGY

--------------------------------------------------------------
>In-frame_ENST00000448150_ENST00000508122_TCGA-78-8640-01A_RASAL2_chr1_178269253_+_GALNTL6_chr4_173730512_length(transcript)=2474nt_BP=1221nt
CCCTCGATTGCTTCAGCCTATCACCCTGGGATGCCGCCTGCCGCTGCCGCCGCCGCCGCCGCCGCCACCGCCACCGCCACCGCCACCGCC
ACCGCCGTGGCTGCCGGGTTTGTGGGATCCGCCGCGGAGCAGGAGCCAGAGCTGTGGCCGGAGCTGTGGCCTGAGAGTCAGGGGGCGGGC
AGGCTCATTCCAGAAGTGGGGGCCGAGGACAGGCGGGCTAGAACCCGGGGCCACCGCCCCCTACCCCTCCTCAGGCTGAGGGAACGGGCA
CTCGGAGCTTCTGAGGCGGCGGCGGCGGGAGCCGGTCAGAGGGGGCGGCCCCTGGCGGCGACGCCCCCAAGCCCAGCCCTGCCCGGCCCC
GCTCCATCCCCAGCCAGAGCCTGGTCTGACCGCGAGAGACGCCGGCGGGGCTGAAGAAGGCGGCTCCGAGGAGGTGGGAGGGCGAGCCTC
CCCTCCCGGGTTCTTCTGCGTCCTCTCCCGGGAGGGACCCACACACACCTGAGCCCGGACCCACCCTTGGTCGGGGCCACGCTGGATCCT
CCTCCCGGCCTGGGTCCCGCCCGCCGACTGCAGGTGGGCTGCATCGCCCGAGCCTCGGGCAGTGGGCGACGGGGAAGGAGGTGAGAGGTG
TCCGCGCCGGCTGCCGCTCGGGTCCCTGCCCTCGCTGCGCGCTCTCCTCCTCCCCTTACCGCAGGCAGGGCGCGGAGCCGCGCGCCAGCC
CGCCCCGAAGCCGCCGCCTCGTCCCCCTCCCGCCTCGGGGCACCATGGAGCTCTCTCCGTCGTCCGGAGGAGCCGCGGAGGCGCTGTCCT
GGCCGGAGATGTTCCCGGCGCTGGAGTCCGACTCGCCGCTGCCCCCGGAGGACCTGGACGCGGTTGTCCCAGTCAGTGGAGCCGTCGCCG
GTGGCATGTTGGATCGGATCCTTCTGGAGTCCGTGTGCCAGCAACAGAGCTGGGTCCGGGTGTACGATGTGAAAGGACCACCCACCCACC
GTCTGTCTTGTGGTCAGTCACCCTACACCGAGACAACAACGTGGGAGCGGAAGTATTGCATCCTCACAGACAGCCAGTTGGTATTGCTCA
ACAAGGAGAAGGAGATACCTGTGGAAGGGGGACAGGAGCAGCAGACAGATTCCACCAAAGGGCGATGCCTGAGGAGAACTGTCAGTGTCC
CTTCCGAGGGTCAGTTTCCCGAGTACCCACCAGAGGGCGCCACTAAACTGGAACACCTGAAGGATAAATTGGAAGAATACATGGCCCGAT
TTTCCAAAGTGAGGATTGTTCGCACCAAGAAAAGAGAAGGACTCATCCGGACCCGTCTCCTGGGGGCATCTATGGCCAGAGGAGAAGTCC
TGACATTCCTGGACTCCCACTGCGAGGTCAATGTGAACTGGCTGCCCCCACTCCTCAACCAAATTGCACTAAACCACAAAACCATCGTGT
GTCCCATGATCGATGTCATTGACCACAATCACTTCGGGTATGAGGCACAAGCTGGGGATGCCATGCGAGGAGCCTTCGACTGGGAAATGT
ACTACAAAAGAATCCCCATCCCTCCAGAGCTCCAGAGGGCAGATCCCAGCGACCCTTTTGAGTCTCCTGTTATGGCTGGAGGTCTCTTTG
CTGTGGATCGGAAATGGTTTTGGGAATTGGGTGGCTATGATCCAGGTTTAGAAATCTGGGGAGGAGAACAGTATGAAATCTCTTTTAAGG
TTTGGATGTGTGGAGGAGAAATGTTTGATGTTCCATGTTCTAGAGTTGGTCATATCTACAGGAAGTACGTTCCATACAAAGTTCCATCTG
GGACAAGCCTGGCAAGAAACCTGAAGCGGGTAGCTGAGACCTGGATGGATGAATTTGCCGAGTACATTTACCAGCGGCGGCCGGAGTACA
GGCATCTCTCCACGGGGGACATCTCTGCCCAGAAGGAGCTGCGCAAGCAGCTCAAGTGCAAGGACTTCAAATGGTTCATGGCTGCTGTGG
CCTGGGACGTGCCTAAATACTACCCTCCAGTGGAGCCCCCGCCTGCTGCCTGGGGGGAGATCCGAAATGTGGCAGCAAATCTCTGTGTGG
ACAGCAAGCATGGAGCCACCGGAACAGAGCTGAGGCTGGACATCTGTGTCAAGGATGGTTCTGAAAGAACATGGTCTCATGAACAGCTTT
TTACCTTTGGATGGAGAGAAGATATTCGACCCGGTGAGCCACTGCATACCCGGAAATTCTGCTTTGATGCGATCTCACACAACAGCCCCG
TTACACTCTATGACTGTCATGGCATGAAGGGGAACCAGCTCTGGGGATACCGGAAGGACAGAACATTATTCCATCCTGTGAGCAACAGCT
GCATGGATTGCAACCCCGCAGAGAAGAAGATTTTCATGGCCAGATGTGACCCTCTCTCTGAGACTCAGCAGTGGATTTTTGAACACATTA

>In-frame_ENST00000448150_ENST00000508122_TCGA-78-8640-01A_RASAL2_chr1_178269253_+_GALNTL6_chr4_173730512_length(amino acids)=688AA_start in transcript=410_stop in transcript=2473
MKKAAPRRWEGEPPLPGSSASSPGRDPHTPEPGPTLGRGHAGSSSRPGSRPPTAGGLHRPSLGQWATGKEVRGVRAGCRSGPCPRCALSS
SPYRRQGAEPRASPPRSRRLVPLPPRGTMELSPSSGGAAEALSWPEMFPALESDSPLPPEDLDAVVPVSGAVAGGMLDRILLESVCQQQS
WVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKL
EHLKDKLEEYMARFSKVRIVRTKKREGLIRTRLLGASMARGEVLTFLDSHCEVNVNWLPPLLNQIALNHKTIVCPMIDVIDHNHFGYEAQ
AGDAMRGAFDWEMYYKRIPIPPELQRADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGEMFDVPCSRVG
HIYRKYVPYKVPSGTSLARNLKRVAETWMDEFAEYIYQRRPEYRHLSTGDISAQKELRKQLKCKDFKWFMAAVAWDVPKYYPPVEPPPAA
WGEIRNVAANLCVDSKHGATGTELRLDICVKDGSERTWSHEQLFTFGWREDIRPGEPLHTRKFCFDAISHNSPVTLYDCHGMKGNQLWGY

--------------------------------------------------------------
>In-frame_ENST00000367649_ENST00000506823_TCGA-78-8640-01A_RASAL2_chr1_178269253_+_GALNTL6_chr4_173730512_length(transcript)=3521nt_BP=809nt
GAAGAAGGCGGCTCCGAGGAGGTGGGAGGGCGAGCCTCCCCTCCCGGGTTCTTCTGCGTCCTCTCCCGGGAGGGACCCACACACACCTGA
GCCCGGACCCACCCTTGGTCGGGGCCACGCTGGATCCTCCTCCCGGCCTGGGTCCCGCCCGCCGACTGCAGGTGGGCTGCATCGCCCGAG
CCTCGGGCAGTGGGCGACGGGGAAGGAGGTGAGAGGTGTCCGCGCCGGCTGCCGCTCGGGTCCCTGCCCTCGCTGCGCGCTCTCCTCCTC
CCCTTACCGCAGGCAGGGCGCGGAGCCGCGCGCCAGCCCGCCCCGAAGCCGCCGCCTCGTCCCCCTCCCGCCTCGGGGCACCATGGAGCT
CTCTCCGTCGTCCGGAGGAGCCGCGGAGGCGCTGTCCTGGCCGGAGATGTTCCCGGCGCTGGAGTCCGACTCGCCGCTGCCCCCGGAGGA
CCTGGACGCGGTTGTCCCAGTCAGTGGAGCCGTCGCCGGTGGCATGTTGGATCGGATCCTTCTGGAGTCCGTGTGCCAGCAACAGAGCTG
GGTCCGGGTGTACGATGTGAAAGGACCACCCACCCACCGTCTGTCTTGTGGTCAGTCACCCTACACCGAGACAACAACGTGGGAGCGGAA
GTATTGCATCCTCACAGACAGCCAGTTGGTATTGCTCAACAAGGAGAAGGAGATACCTGTGGAAGGGGGACAGGAGCAGCAGACAGATTC
CACCAAAGGGCGATGCCTGAGGAGAACTGTCAGTGTCCCTTCCGAGGGTCAGTTTCCCGAGTACCCACCAGAGGGCGCCACTAAACTGGA
ACACCTGAAGGATAAATTGGAAGAATACATGGCCCGATTTTCCAAAGTGAGGATTGTTCGCACCAAGAAAAGAGAAGGACTCATCCGGAC
CCGTCTCCTGGGGGCATCTATGGCCAGAGGAGAAGTCCTGACATTCCTGGACTCCCACTGCGAGGTCAATGTGAACTGGCTGCCCCCACT
CCTCAACCAAATTGCACTAAACCACAAAACCATCGTGTGTCCCATGATCGATGTCATTGACCACAATCACTTCGGGTATGAGGCACAAGC
TGGGGATGCCATGCGAGGAGCCTTCGACTGGGAAATGTACTACAAAAGAATCCCCATCCCTCCAGAGCTCCAGAGGGCAGATCCCAGCGA
CCCTTTTGAGTCTCCTGTTATGGCTGGAGGTCTCTTTGCTGTGGATCGGAAATGGTTTTGGGAATTGGGTGGCTATGATCCAGGTTTAGA
AATCTGGGGAGGAGAACAGTATGAAATCTCTTTTAAGGTTTGGATGTGTGGAGGAGAAATGTTTGATGTTCCATGTTCTAGAGTTGGTCA
TATCTACAGGAAGTACGTTCCATACAAAGTTCCATCTGGGACAAGCCTGGCAAGAAACCTGAAGCGGGTAGCTGAGACCTGGATGGATGA
ATTTGCCGAGTACATTTACCAGCGGCGGCCGGAGTACAGGCATCTCTCCACGGGGGACATCTCTGCCCAGAAGGAGCTGCGCAAGCAGCT
CAAGTGCAAGGACTTCAAATGGTTCATGGCTGCTGTGGCCTGGGACGTGCCTAAATACTACCCTCCAGTGGAGCCCCCGCCTGCTGCCTG
GGGGGAGATCCGAAATGTGGCAGCAAATCTCTGTGTGGACAGCAAGCATGGAGCCACCGGAACAGAGCTGAGGCTGGACATCTGTGTCAA
GGATGGTTCTGAAAGAACATGGTCTCATGAACAGCTTTTTACCTTTGGATGGAGAGAAGATATTCGACCCGGTGAGCCACTGCATACCCG
GAAATTCTGCTTTGATGCGATCTCACACAACAGCCCCGTTACACTCTATGACTGTCATGGCATGAAGGGGAACCAGCTCTGGGGATACCG
GAAGGACAGAACATTATTCCATCCTGTGAGCAACAGCTGCATGGATTGCAACCCCGCAGAGAAGAAGATTTTCATGGCCAGATGTGACCC
TCTCTCTGAGACTCAGCAGTGGATTTTTGAACACATTAATATGACTGTTTTAGAAAAATTTAACCACCATGCCAACTCCTAGAAAGAAGA
AAGGAAGAAAGAGTGATTACCTACAGGTTATAAATTAAATTTTAGCCAGCATCTGGGTCGAAGGAGTCAGGAATAACATTTCCTCGATCC
AGGAAGGCTGGTTTAAAAATTTGCAAATGCCATGTCAAAGTAGGTTGTTTTGAAGAACTTCCTGCATCTGAAGAACTTGGCTGAGAATCT
CACCAGCTGCTTCTGAGAACTCGAGACTAGCAGTTCCCTTGCTGGCCAAGGGCAAAGATAATTTAGGGACTTTTCAAAACAACTGCTGAG
CTAATAAATCCTAGCATTTCTCAGGTCAAATCCTGCAGTAGTGAGTAGCTATGAATGGATCCTATTAACTGGGTGGGAGGGGGGTGAAAA
TGGAGTGCATGACTGCTCTGACAACCTGAGGATATCACAGGTTTAGAACTAGCCAAGCTTAAGGGGTGAGCTGTACTCTTTGGTGCCATT
CTCTGACTAAGAATGGGTTCAGCAGGTTTAACCCTTAAAAGTGCTGCAGATGATTTCAGAGTGCTCACACTATTCTGTTTTTTTTATTTT
TATTTTTAAATGAGGGTGCAATATCTAATGTAAGACTTAAATTACATAATGAAATGGACATCCAGTGTTCCCATTCTTTCGTTTATATTT
GCCATTTTTTTTTCAGAGCAAAGTTTCTTTTTTATGAAAGTTCATGCTCCATGAATCCACTGAATTTCTAATTCAGTGCCCTTCTATGAA
TCCAGTTAAAAACAAAAGCAAAAGCAAAAATCTATGCTATCAAGTTACTCCAAAGAAAGATTTCACAGAAGCAGCAAAACCATATAAGAT
TTAGGAGAGGGACTTCCCTGGGAAATCTATTTTTACTTTTCTATTATTTTTAAAATCTTAAAAGTCTGATATTTGTCCAGTCATAATTTT
TATTAAGCAAGGAAATGGAGTGAGTTTGATGTAATTTGTTTAGGAGATTCTTAAACCCAAATAAATCTACACTCCAAGTGATATGTGAAA
ATGGCTTAGTTCACTTCAATTCTGTTTAGTCAGTGGTGGGAGCTTAGAAGTGGTTTTATTTGTTCGTTTGTTTGGGTTTTGCTTTTGTTT
TTTATTTTTTTCTTGTTTTTTTTTTGTAGTGTTGAATTAATGATGTTCTTTTATTTGGAAGCTCATAAAAGGAATTACCATTAATAAAGT
GTTTCTGACACCATTTTCTGTTAATGGGACAATATTTCGGGGATGAAGAAAGGAATGCTCCGAAAACTAAATGGAACACTTAATCCTTAA
AGCAATTTTTTACTGTTCAATAATATCACATTGGGGGAAGAAAACACAGGTATCAAGGTGGTTCTTGGGAAAAAAGAATCATGTTTATTA
TATATCTCTCAAGTTTTTTTGGTATAAAAATGTTTTAACTTTGCTTTCTTTTTGGTTTTTGTTTGAAGTTGGTTTTCCTGTTAATAAAAA

>In-frame_ENST00000367649_ENST00000506823_TCGA-78-8640-01A_RASAL2_chr1_178269253_+_GALNTL6_chr4_173730512_length(amino acids)=631AA_start in transcript=166_stop in transcript=2061
MHRPSLGQWATGKEVRGVRAGCRSGPCPRCALSSSPYRRQGAEPRASPPRSRRLVPLPPRGTMELSPSSGGAAEALSWPEMFPALESDSP
LPPEDLDAVVPVSGAVAGGMLDRILLESVCQQQSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQE
QQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEHLKDKLEEYMARFSKVRIVRTKKREGLIRTRLLGASMARGEVLTFLDSHCEVNVN
WLPPLLNQIALNHKTIVCPMIDVIDHNHFGYEAQAGDAMRGAFDWEMYYKRIPIPPELQRADPSDPFESPVMAGGLFAVDRKWFWELGGY
DPGLEIWGGEQYEISFKVWMCGGEMFDVPCSRVGHIYRKYVPYKVPSGTSLARNLKRVAETWMDEFAEYIYQRRPEYRHLSTGDISAQKE
LRKQLKCKDFKWFMAAVAWDVPKYYPPVEPPPAAWGEIRNVAANLCVDSKHGATGTELRLDICVKDGSERTWSHEQLFTFGWREDIRPGE
PLHTRKFCFDAISHNSPVTLYDCHGMKGNQLWGYRKDRTLFHPVSNSCMDCNPAEKKIFMARCDPLSETQQWIFEHINMTVLEKFNHHAN

--------------------------------------------------------------
>In-frame_ENST00000367649_ENST00000508122_TCGA-78-8640-01A_RASAL2_chr1_178269253_+_GALNTL6_chr4_173730512_length(transcript)=2062nt_BP=809nt
GAAGAAGGCGGCTCCGAGGAGGTGGGAGGGCGAGCCTCCCCTCCCGGGTTCTTCTGCGTCCTCTCCCGGGAGGGACCCACACACACCTGA
GCCCGGACCCACCCTTGGTCGGGGCCACGCTGGATCCTCCTCCCGGCCTGGGTCCCGCCCGCCGACTGCAGGTGGGCTGCATCGCCCGAG
CCTCGGGCAGTGGGCGACGGGGAAGGAGGTGAGAGGTGTCCGCGCCGGCTGCCGCTCGGGTCCCTGCCCTCGCTGCGCGCTCTCCTCCTC
CCCTTACCGCAGGCAGGGCGCGGAGCCGCGCGCCAGCCCGCCCCGAAGCCGCCGCCTCGTCCCCCTCCCGCCTCGGGGCACCATGGAGCT
CTCTCCGTCGTCCGGAGGAGCCGCGGAGGCGCTGTCCTGGCCGGAGATGTTCCCGGCGCTGGAGTCCGACTCGCCGCTGCCCCCGGAGGA
CCTGGACGCGGTTGTCCCAGTCAGTGGAGCCGTCGCCGGTGGCATGTTGGATCGGATCCTTCTGGAGTCCGTGTGCCAGCAACAGAGCTG
GGTCCGGGTGTACGATGTGAAAGGACCACCCACCCACCGTCTGTCTTGTGGTCAGTCACCCTACACCGAGACAACAACGTGGGAGCGGAA
GTATTGCATCCTCACAGACAGCCAGTTGGTATTGCTCAACAAGGAGAAGGAGATACCTGTGGAAGGGGGACAGGAGCAGCAGACAGATTC
CACCAAAGGGCGATGCCTGAGGAGAACTGTCAGTGTCCCTTCCGAGGGTCAGTTTCCCGAGTACCCACCAGAGGGCGCCACTAAACTGGA
ACACCTGAAGGATAAATTGGAAGAATACATGGCCCGATTTTCCAAAGTGAGGATTGTTCGCACCAAGAAAAGAGAAGGACTCATCCGGAC
CCGTCTCCTGGGGGCATCTATGGCCAGAGGAGAAGTCCTGACATTCCTGGACTCCCACTGCGAGGTCAATGTGAACTGGCTGCCCCCACT
CCTCAACCAAATTGCACTAAACCACAAAACCATCGTGTGTCCCATGATCGATGTCATTGACCACAATCACTTCGGGTATGAGGCACAAGC
TGGGGATGCCATGCGAGGAGCCTTCGACTGGGAAATGTACTACAAAAGAATCCCCATCCCTCCAGAGCTCCAGAGGGCAGATCCCAGCGA
CCCTTTTGAGTCTCCTGTTATGGCTGGAGGTCTCTTTGCTGTGGATCGGAAATGGTTTTGGGAATTGGGTGGCTATGATCCAGGTTTAGA
AATCTGGGGAGGAGAACAGTATGAAATCTCTTTTAAGGTTTGGATGTGTGGAGGAGAAATGTTTGATGTTCCATGTTCTAGAGTTGGTCA
TATCTACAGGAAGTACGTTCCATACAAAGTTCCATCTGGGACAAGCCTGGCAAGAAACCTGAAGCGGGTAGCTGAGACCTGGATGGATGA
ATTTGCCGAGTACATTTACCAGCGGCGGCCGGAGTACAGGCATCTCTCCACGGGGGACATCTCTGCCCAGAAGGAGCTGCGCAAGCAGCT
CAAGTGCAAGGACTTCAAATGGTTCATGGCTGCTGTGGCCTGGGACGTGCCTAAATACTACCCTCCAGTGGAGCCCCCGCCTGCTGCCTG
GGGGGAGATCCGAAATGTGGCAGCAAATCTCTGTGTGGACAGCAAGCATGGAGCCACCGGAACAGAGCTGAGGCTGGACATCTGTGTCAA
GGATGGTTCTGAAAGAACATGGTCTCATGAACAGCTTTTTACCTTTGGATGGAGAGAAGATATTCGACCCGGTGAGCCACTGCATACCCG
GAAATTCTGCTTTGATGCGATCTCACACAACAGCCCCGTTACACTCTATGACTGTCATGGCATGAAGGGGAACCAGCTCTGGGGATACCG
GAAGGACAGAACATTATTCCATCCTGTGAGCAACAGCTGCATGGATTGCAACCCCGCAGAGAAGAAGATTTTCATGGCCAGATGTGACCC

>In-frame_ENST00000367649_ENST00000508122_TCGA-78-8640-01A_RASAL2_chr1_178269253_+_GALNTL6_chr4_173730512_length(amino acids)=632AA_start in transcript=166_stop in transcript=2061
MHRPSLGQWATGKEVRGVRAGCRSGPCPRCALSSSPYRRQGAEPRASPPRSRRLVPLPPRGTMELSPSSGGAAEALSWPEMFPALESDSP
LPPEDLDAVVPVSGAVAGGMLDRILLESVCQQQSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQE
QQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEHLKDKLEEYMARFSKVRIVRTKKREGLIRTRLLGASMARGEVLTFLDSHCEVNVN
WLPPLLNQIALNHKTIVCPMIDVIDHNHFGYEAQAGDAMRGAFDWEMYYKRIPIPPELQRADPSDPFESPVMAGGLFAVDRKWFWELGGY
DPGLEIWGGEQYEISFKVWMCGGEMFDVPCSRVGHIYRKYVPYKVPSGTSLARNLKRVAETWMDEFAEYIYQRRPEYRHLSTGDISAQKE
LRKQLKCKDFKWFMAAVAWDVPKYYPPVEPPPAAWGEIRNVAANLCVDSKHGATGTELRLDICVKDGSERTWSHEQLFTFGWREDIRPGE
PLHTRKFCFDAISHNSPVTLYDCHGMKGNQLWGYRKDRTLFHPVSNSCMDCNPAEKKIFMARCDPLSETQQWIFEHINMTVLEKFNHHAN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RASAL2-GALNTL6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RASAL2-GALNTL6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RASAL2-GALNTL6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource