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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RB1-FNDC3A (FusionGDB2 ID:72097)

Fusion Gene Summary for RB1-FNDC3A

check button Fusion gene summary
Fusion gene informationFusion gene name: RB1-FNDC3A
Fusion gene ID: 72097
HgeneTgene
Gene symbol

RB1

FNDC3A

Gene ID

5925

22862

Gene nameRB transcriptional corepressor 1fibronectin type III domain containing 3A
SynonymsOSRC|PPP1R130|RB|p105-Rb|p110-RB1|pRb|pp110FNDC3|HUGO|bA203I16.1|bA203I16.5
Cytomap

13q14.2

13q14.2

Type of geneprotein-codingprotein-coding
Descriptionretinoblastoma-associated proteinGOS563 exon 17 substitution mutation causes premature stopexon 17 tumor GOS561 substitution mutation causes premature stopprepro-retinoblastoma-associated proteinprotein phosphatase 1, regulatory subunit 130retinoblasfibronectin type-III domain-containing protein 3Ahuman gene expressed in odontoblasts
Modification date2020032920200313
UniProtAcc.

Q9Y2H6

Ensembl transtripts involved in fusion geneENST00000267163, ENST00000484879, 
ENST00000492622, ENST00000541916, 
ENST00000398316, 
Fusion gene scores* DoF score23 X 9 X 13=26919 X 10 X 4=360
# samples 2710
** MAII scorelog2(27/2691*10)=-3.31711107858959
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RB1 [Title/Abstract] AND FNDC3A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFNDC3A(49688867)-RB1(49037867), # samples:2
RB1(48942740)-FNDC3A(49742748), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRB1

GO:0043550

regulation of lipid kinase activity

16286473

HgeneRB1

GO:0045892

negative regulation of transcription, DNA-templated

10783144|12065415|19223331

HgeneRB1

GO:2000679

positive regulation of transcription regulatory region DNA binding

25100735


check buttonFusion gene breakpoints across RB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FNDC3A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-04-1365RB1chr13

48942740

+FNDC3Achr13

49742748

+


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Fusion Gene ORF analysis for RB1-FNDC3A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000267163ENST00000492622RB1chr13

48942740

+FNDC3Achr13

49742748

+
In-frameENST00000267163ENST00000541916RB1chr13

48942740

+FNDC3Achr13

49742748

+
In-frameENST00000267163ENST00000398316RB1chr13

48942740

+FNDC3Achr13

49742748

+
intron-3CDSENST00000484879ENST00000492622RB1chr13

48942740

+FNDC3Achr13

49742748

+
intron-3CDSENST00000484879ENST00000541916RB1chr13

48942740

+FNDC3Achr13

49742748

+
intron-3CDSENST00000484879ENST00000398316RB1chr13

48942740

+FNDC3Achr13

49742748

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000267163RB1chr1348942740+ENST00000492622FNDC3Achr1349742748+6209126513838241228
ENST00000267163RB1chr1348942740+ENST00000541916FNDC3Achr1349742748+4804126513838241228
ENST00000267163RB1chr1348942740+ENST00000398316FNDC3Achr1349742748+6023126513838241228

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000267163ENST00000492622RB1chr1348942740+FNDC3Achr1349742748+0.0001277590.9998722
ENST00000267163ENST00000541916RB1chr1348942740+FNDC3Achr1349742748+0.000156470.9998435
ENST00000267163ENST00000398316RB1chr1348942740+FNDC3Achr1349742748+0.0001354340.9998646

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Fusion Genomic Features for RB1-FNDC3A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RB1chr1348942740+FNDC3Achr1349742748+0.0005724570.99942756
RB1chr1348942740+FNDC3Achr1349742748+0.0005724570.99942756

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RB1-FNDC3A


check button Go to

FGviewer for the breakpoints of chr13:48942740-chr13:49742748

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FNDC3A

Q9Y2H6

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Mediates spermatid-Sertoli adhesion during spermatogenesis. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRB1chr13:48942740chr13:49742748ENST00000267163+112710_18375.6666666666667929.0Compositional biasNote=Poly-Ala
HgeneRB1chr13:48942740chr13:49742748ENST00000267163+112720_29375.6666666666667929.0Compositional biasNote=Poly-Pro
TgeneFNDC3Achr13:48942740chr13:49742748ENST000003983166241046_1151289.66666666666671143.0DomainFibronectin type-III 9
TgeneFNDC3Achr13:48942740chr13:49742748ENST00000398316624373_465289.66666666666671143.0DomainFibronectin type-III 2
TgeneFNDC3Achr13:48942740chr13:49742748ENST00000398316624469_562289.66666666666671143.0DomainFibronectin type-III 3
TgeneFNDC3Achr13:48942740chr13:49742748ENST00000398316624566_660289.66666666666671143.0DomainFibronectin type-III 4
TgeneFNDC3Achr13:48942740chr13:49742748ENST00000398316624664_757289.66666666666671143.0DomainFibronectin type-III 5
TgeneFNDC3Achr13:48942740chr13:49742748ENST00000398316624761_851289.66666666666671143.0DomainFibronectin type-III 6
TgeneFNDC3Achr13:48942740chr13:49742748ENST00000398316624861_950289.66666666666671143.0DomainFibronectin type-III 7
TgeneFNDC3Achr13:48942740chr13:49742748ENST00000398316624951_1045289.66666666666671143.0DomainFibronectin type-III 8
TgeneFNDC3Achr13:48942740chr13:49742748ENST000004926228261046_1151345.66666666666671199.0DomainFibronectin type-III 9
TgeneFNDC3Achr13:48942740chr13:49742748ENST00000492622826373_465345.66666666666671199.0DomainFibronectin type-III 2
TgeneFNDC3Achr13:48942740chr13:49742748ENST00000492622826469_562345.66666666666671199.0DomainFibronectin type-III 3
TgeneFNDC3Achr13:48942740chr13:49742748ENST00000492622826566_660345.66666666666671199.0DomainFibronectin type-III 4
TgeneFNDC3Achr13:48942740chr13:49742748ENST00000492622826664_757345.66666666666671199.0DomainFibronectin type-III 5
TgeneFNDC3Achr13:48942740chr13:49742748ENST00000492622826761_851345.66666666666671199.0DomainFibronectin type-III 6
TgeneFNDC3Achr13:48942740chr13:49742748ENST00000492622826861_950345.66666666666671199.0DomainFibronectin type-III 7
TgeneFNDC3Achr13:48942740chr13:49742748ENST00000492622826951_1045345.66666666666671199.0DomainFibronectin type-III 8
TgeneFNDC3Achr13:48942740chr13:49742748ENST000005419168261046_1151345.66666666666671199.0DomainFibronectin type-III 9
TgeneFNDC3Achr13:48942740chr13:49742748ENST00000541916826373_465345.66666666666671199.0DomainFibronectin type-III 2
TgeneFNDC3Achr13:48942740chr13:49742748ENST00000541916826469_562345.66666666666671199.0DomainFibronectin type-III 3
TgeneFNDC3Achr13:48942740chr13:49742748ENST00000541916826566_660345.66666666666671199.0DomainFibronectin type-III 4
TgeneFNDC3Achr13:48942740chr13:49742748ENST00000541916826664_757345.66666666666671199.0DomainFibronectin type-III 5
TgeneFNDC3Achr13:48942740chr13:49742748ENST00000541916826761_851345.66666666666671199.0DomainFibronectin type-III 6
TgeneFNDC3Achr13:48942740chr13:49742748ENST00000541916826861_950345.66666666666671199.0DomainFibronectin type-III 7
TgeneFNDC3Achr13:48942740chr13:49742748ENST00000541916826951_1045345.66666666666671199.0DomainFibronectin type-III 8
TgeneFNDC3Achr13:48942740chr13:49742748ENST000003983166241177_1197289.66666666666671143.0TransmembraneHelical
TgeneFNDC3Achr13:48942740chr13:49742748ENST000004926228261177_1197345.66666666666671199.0TransmembraneHelical
TgeneFNDC3Achr13:48942740chr13:49742748ENST000005419168261177_1197345.66666666666671199.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRB1chr13:48942740chr13:49742748ENST00000267163+1127860_876375.6666666666667929.0MotifBipartite nuclear localization signal
HgeneRB1chr13:48942740chr13:49742748ENST00000267163+1127373_579375.6666666666667929.0RegionNote=Domain A
HgeneRB1chr13:48942740chr13:49742748ENST00000267163+1127373_771375.6666666666667929.0RegionNote=Pocket%3B binds T and E1A
HgeneRB1chr13:48942740chr13:49742748ENST00000267163+1127580_639375.6666666666667929.0RegionNote=Spacer
HgeneRB1chr13:48942740chr13:49742748ENST00000267163+1127640_771375.6666666666667929.0RegionNote=Domain B
TgeneFNDC3Achr13:48942740chr13:49742748ENST0000039831662468_133289.66666666666671143.0Compositional biasNote=Pro-rich
TgeneFNDC3Achr13:48942740chr13:49742748ENST0000049262282668_133345.66666666666671199.0Compositional biasNote=Pro-rich
TgeneFNDC3Achr13:48942740chr13:49742748ENST0000054191682668_133345.66666666666671199.0Compositional biasNote=Pro-rich
TgeneFNDC3Achr13:48942740chr13:49742748ENST00000398316624268_369289.66666666666671143.0DomainFibronectin type-III 1
TgeneFNDC3Achr13:48942740chr13:49742748ENST00000492622826268_369345.66666666666671199.0DomainFibronectin type-III 1
TgeneFNDC3Achr13:48942740chr13:49742748ENST00000541916826268_369345.66666666666671199.0DomainFibronectin type-III 1


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Fusion Gene Sequence for RB1-FNDC3A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000267163_ENST00000492622_TCGA-04-1365_RB1_chr13_48942740_+_FNDC3A_chr13_49742748_length(transcript)=6209nt_BP=1265nt
TCCGGTTTTTCTCAGGGGACGTTGAAATTATTTTTGTAACGGGAGTCGGGAGAGGACGGGGCGTGCCCCGACGTGCGCGCGCGTCGTCCT
CCCCGGCGCTCCTCCACAGCTCGCTGGCTCCCGCCGCGGAAAGGCGTCATGCCGCCCAAAACCCCCCGAAAAACGGCCGCCACCGCCGCC
GCTGCCGCCGCGGAACCCCCGGCACCGCCGCCGCCGCCCCCTCCTGAGGAGGACCCAGAGCAGGACAGCGGCCCGGAGGACCTGCCTCTC
GTCAGGCTTGAGTTTGAAGAAACAGAAGAACCTGATTTTACTGCATTATGTCAGAAATTAAAGATACCAGATCATGTCAGAGAGAGAGCT
TGGTTAACTTGGGAGAAAGTTTCATCTGTGGATGGAGTATTGGGAGGTTATATTCAAAAGAAAAAGGAACTGTGGGGAATCTGTATCTTT
ATTGCAGCAGTTGACCTAGATGAGATGTCGTTCACTTTTACTGAGCTACAGAAAAACATAGAAATCAGTGTCCATAAATTCTTTAACTTA
CTAAAAGAAATTGATACCAGTACCAAAGTTGATAATGCTATGTCAAGACTGTTGAAGAAGTATGATGTATTGTTTGCACTCTTCAGCAAA
TTGGAAAGGACATGTGAACTTATATATTTGACACAACCCAGCAGTTCGATATCTACTGAAATAAATTCTGCATTGGTGCTAAAAGTTTCT
TGGATCACATTTTTATTAGCTAAAGGGGAAGTATTACAAATGGAAGATGATCTGGTGATTTCATTTCAGTTAATGCTATGTGTCCTTGAC
TATTTTATTAAACTCTCACCTCCCATGTTGCTCAAAGAACCATATAAAACAGCTGTTATACCCATTAATGGTTCACCTCGAACACCCAGG
CGAGGTCAGAACAGGAGTGCACGGATAGCAAAACAACTAGAAAATGATACAAGAATTATTGAAGTTCTCTGTAAAGAACATGAATGTAAT
ATAGATGAGGTGAAAAATGTTTATTTCAAAAATTTTATACCTTTTATGAATTCTCTTGGACTTGTAACATCTAATGGACTTCCAGAGGTT
GAAAATCTTTCTAAACGATACGAAGAAATTTATCTTAAAAATAAAGATCTAGATGCAAGATTATTTTTGGATCATGATAAAACTCTTCAG
ACTGATTCTATAGACAGTTTTGAAACACAGAGAACACCACGAAAAAGTAACCTTGATGAAGAGGTGAATGTAATTCCTCCACACACTCCA
GTTAGAGTCCAGGCAGAATATAATTCTATAAAGGGAACTCCTTCAGAGGCTGAAATCTTTACCACCTTGAGCTGTGAACCTGATATACCT
AATCCACCAAGGATAGCCAATCGGACCAAAAATTCACTCACTTTGCAATGGAAGGCACCTAGTGACAATGGTTCTAAAATCCAAAACTTT
GTATTAGAATGGGATGAAGGAAAAGGAAATGGAGAATTTTGTCAGTGTTACATGGGCTCACAGAAACAATTTAAAATTACTAAACTTTCA
CCAGCAATGGGCTGTAAATTCAGACTATCGGCCAGAAATGACTATGGTACAAGTGGTTTTAGTGAAGAAGTCTTATATTACACCTCAGGC
TGTGCTCCTTCTATGCCAGCAAGTCCTGTATTAACCAAGGCTGGAATTACTTGGTTATCCTTACAATGGAGTAAGCCCTCAGGAACACCA
TCAGATGAAGGAATTTCTTACATTTTAGAGATGGAGGAAGAAACTTCAGGATATGGTTTTAAGCCTAAATATGATGGAGAAGATCTTGCT
TACACAGTGAAAAATCTCAGACGTAGTACTAAGTATAAATTTAAGGTTATTGCTTACAACTCAGAAGGTAAAAGTAATCCAAGTGAAGTA
GTAGAATTTACTACTTGCCCTGATAAACCAGGCATACCTGTAAAGCCTTCAGTGAAAGGAAAGATACATTCACACAGTTTTAAAATAACC
TGGGATCCACCAAAAGACAATGGCGGAGCAACCATCAATAAATATGTAGTGGAGATGGCAGAAGGTTCTAACGGAAACAAATGGGAAATG
ATATACAGTGGTGCTACCAGGGAACATCTTTGTGATCGACTGAATCCAGGCTGTTTCTATCGTTTACGAGTTTACTGCATCAGTGATGGA
GGACAGAGTGCGGTCTCTGAATCTTTACTTGTGCAGACTCCAGCTGTGCCTCCTGGCCCATGCCTCCCTCCCAGATTACAGGGTAGACCC
AAAGCAAAAGAAATACAGTTACGATGGGGACCCCCTCTGGTTGATGGTGGATCACCCATTTCCTGTTACAGTGTGGAAATGTCTCCTATA
GAAAAAGATGAACCTAGAGAAGTTTACCAAGGTTCTGAAGTAGAATGTACAGTGAGCAGCCTTCTTCCTGGAAAGACATACAGCTTCAGA
CTACGTGCAGCTAACAAAATGGGGTTTGGACCATTTTCAGAAAAATGTGATATTACTACAGCCCCTGGGCCACCAGATCAGTGCAAGCCC
CCTCAAGTGACATGTAGATCTGCAACTTGTGCACAAGTGAATTGGGAGGTTCCTTTGAGTAATGGAACAGATGTCACTGAATATCGACTG
GAGTGGGGAGGAGTTGAAGGAAGTATGCAGATATGTTACTGTGGGCCTGGTCTCAGTTATGAAATAAAAGGACTTTCACCAGCAACTACC
TATTATTGCAGGGTCCAGGCTCTGAGTGTTGTGGGTGCAGGCCCTTTCAGTGAAGTAGTAGCCTGTGTGACTCCACCATCAGTTCCTGGC
ATTGTGACCTGTCTTCAAGAAATAAGCGATGATGAGATAGAAAATCCCCATTATTCACCTTCTACATGCCTTGCAATAAGCTGGGAAAAG
CCTTGTGATCATGGTTCGGAAATCCTTGCCTACAGCATAGACTTTGGAGATAAACAATCCCTAACAGTGGGAAAGGTTACAAGCTATATT
ATCAACAATTTGCAACCAGATACAACATACAGAATACGAATTCAAGCCTTGAATAGCCTTGGAGCTGGTCCTTTCAGCCATATGATAAAA
TTAAAAACTAAGCCTCTCCCTCCTGATCCACCTCGTCTGGAATGTGTTGCCTTTAGCCACCAGAACCTTAAGCTGAAATGGGGAGAAGGA
ACTCCAAAGACATTGTCAACCGATTCTATTCAGTACCACCTTCAGATGGAGGATAAGAATGGACGGTTTGTATCCCTATACAGAGGACCA
TGTCATACATACAAAGTACAAAGACTTAATGAGTCAACATCCTATAAATTCTGTATTCAAGCTTGTAATGAAGCTGGGGAAGGTCCCCTC
TCCCAAGAATATATTTTCACTACTCCAAAATCTGTCCCAGCTGCCTTGAAAGCCCCCAAAATAGAGAAAGTAAATGATCACATTTGTGAA
ATTACATGGGAGTGTTTACAGCCAATGAAAGGTGATCCAGTTATTTACAGTCTTCAAGTTATGTTGGGAAAAGATTCAGAATTCAAACAG
ATTTACAAGGGTCCCGACTCTTCCTTCCGGTATTCCAGCCTTCAGCTGAACTGTGAATATCGCTTCCGTGTATGTGCCATTCGCCAGTGC
CAAGACTCTCTGGGACACCAGGACCTCGTAGGTCCCTACAGCACCACAGTGCTCTTCATCTCTCAGAGGACTGAACCACCAGCCAGCACC
AACAGAGACACTGTGGAAAGCACAAGGACCCGACGGGCACTGAGTGACGAGCAGTGTGCTGCCGTCATCCTTGTGCTGTTTGCTTTCTTT
TCCATTTTGATTGCCTTTATCATTCAGTACTTTGTAATCAAGTGAAAATATAACTTTATTTTTTAACTCTATTACATTTTATTTTGTCAT
GTACTAAAATTATTTCTGTATTGCTTTTATAAAAAACAGTGGCATTTAGCACTGGCATTGAGACTATAGCACATCATTTTTGCCATTTTC
AGTGCTTATATTGTTAGGTAGAGGCTGGCACTTTATTAGAATGCAAGCCACAAAAATATCAATTTTGTTTTTTTTGTTAGGGTGGGTCTT
CTTTTTTTCTTTCCCTCTCTCTTTTTTTAACAAATGCCTTCTTATAGAAAAACTTTCTAAGAGGCAACAATTTAGAATGGATATTTTGAC
GAATCGGCATGAGTGTAACAGTGATAACCTGATCTGTTTGTTTTAAAGATTATTACCAAGTGAAAAATTCAGAATGAATAGAATTTACAC
TAACATGCTATATAAAATGTTAAAGTCTGATGCTGTGAAAGCAATCTAGTGCTATATTTCTACCTCCTCATTTGTCTTAATTATTTGGTA
AGTGGGATTATGATGAGTAACTGGAGGGGCTTAGAAACAAAAACTGGATGAAAGAGTATGCATGAAGAAAAGCTTCTTTGATAAATGTGG
AGTTCTTCATTATAAATATATATTCATGAATTCACAGATAAGTACTTAAAGAACAGACAGTTTACTTGGCCTAAAAATATTTTGATGTTT
ACTCAAAAAGTACCTCTTCAGGTCTTGAGAACATGGAAAAGAATTGAGTGCTTTTAAATACTTTTTAGAAAGTAATCATAAAAGTAAATT
GAATTTCAAACCTATTTGGCTTCTGTTTTGTGAACCTTTGAACTATATGTATGTGTATAAGGGTATACACATACATATATGGCATATAAC
AAGTGTACACATATACACATAACAAGTGTAGAAGTATATATTACATACATACACTCACTCTGTCTGGTATAGGCTAATTTTGAAGAACTC
CCATAAGTTTCTGCTGCTTCTCCCATAACTGCTGCCACCACCATCAGAATTCATAATCAAACCTAACCTTTTTGTTTGGGGCACCAAATC
TGAAGACAAAATTAATTTGCACCAGTAAACTTCAAGCTGCTTTCTTTCTTGAAAACTAAACGTTTAACGTATAATGTCTGTTTGGATACT
GTTCCAAATTGTTGATTGCATGTGGTTAATGTTGCATTAGAGCACTTTGCAATTGCATAATTCATTAATGTTTTGTGAGCTTGCATTTGT
GAGTTATTGGATGATCAGACTGAATTTTGTCAAGTATCACATTGTACATCTTGCCTAGATGTCGATGACTGCAAGTAATAATACAGTTTA
TAATGAAACTATCTACAATTCTTGTTTTAGCACATCTGTTATCCGTAAAACACCTGTAACTAGCTTTTTTAATTTATTATTTGAATTTTA
GGATAGCGAATCACTAATTTTTAGTTGCTGAGGTTGGCATTTTAGTGATTATTAAGCACTTCTGTCAGTCTTTGAAAAAAGAACGTATTT
TTTGTGCTTTGAAGATCTCTGAAGAATTTCTTTTATAATAGAATGGGCATGTATTGTAACAGTTTTATGTCAAATGATCTGTGCTGTAGA
AAAACATTAACCCTTGTTCAAAAAAGAAATGGATAAACTTGGCCTTTCTAAGTGGTAAGAATGACCTGTCACTATAATATACTGTATGTT
TACATTTTATTTAAATTTAATCTCTTATGTATAGGGTGATAACCTTCCCCAGAAACAACAGTGATTGCGATTGTTTTCTAGAAACTTCTT
TAAAGTGCCACATTTGGCAGTACAAATGAGTCTGAGTGTAATAGCCCAGAGATTTATATATAGTTGAATGTCTAAAATGGTAAAATGTGC
CACTGTGTCAAGTTACAGTGGCTTATGTTTTTCATAGTAATTCAAATGAACTTCCTATTTTTGATAGTAAATGTCATTTAATAGTATACT
TGCCATTTGAGCCTCACTGCAAAATTAGTGCAGAGGAGAAAACAATTTTTAATGTAATCTTGATTTTACCTCATATACTGTACATTCCAA
AAACTCTAAACTTTTTAAAGATTATAGATACACTACCAAACATATCACCTTAAAATTGTATAAGGCTGAATGAACTTCATACAAATGAAA
AAAATCTCATAAAAATACATAAACTATGTAGCAAAAGTATCTGTAAAATCCATGGAAAATAAAAGTTGTATCATTCTTTTTGAGATACGT
TTATTGTATTCATATATATTCATTATTTGCTACCTGTTTAAGAAAGTGAAATGTTATGGTCTCCCCTCTTCCAATGAGCTTAAAACATTT

>In-frame_ENST00000267163_ENST00000492622_TCGA-04-1365_RB1_chr13_48942740_+_FNDC3A_chr13_49742748_length(amino acids)=1228AA_start in transcript=138_stop in transcript=3824
MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFEETEEPDFTALCQKLKIPDHVRERAWLTWEKVSSVDGVLGG
YIQKKKELWGICIFIAAVDLDEMSFTFTELQKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSS
ISTEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYKTAVIPINGSPRTPRRGQNRSARIAKQLEND
TRIIEVLCKEHECNIDEVKNVYFKNFIPFMNSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKS
NLDEEVNVIPPHTPVRVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQC
YMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETS
GYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYV
VEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDG
GSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWE
VPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENP
HYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECV
AFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAAL
KAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTT

--------------------------------------------------------------
>In-frame_ENST00000267163_ENST00000541916_TCGA-04-1365_RB1_chr13_48942740_+_FNDC3A_chr13_49742748_length(transcript)=4804nt_BP=1265nt
TCCGGTTTTTCTCAGGGGACGTTGAAATTATTTTTGTAACGGGAGTCGGGAGAGGACGGGGCGTGCCCCGACGTGCGCGCGCGTCGTCCT
CCCCGGCGCTCCTCCACAGCTCGCTGGCTCCCGCCGCGGAAAGGCGTCATGCCGCCCAAAACCCCCCGAAAAACGGCCGCCACCGCCGCC
GCTGCCGCCGCGGAACCCCCGGCACCGCCGCCGCCGCCCCCTCCTGAGGAGGACCCAGAGCAGGACAGCGGCCCGGAGGACCTGCCTCTC
GTCAGGCTTGAGTTTGAAGAAACAGAAGAACCTGATTTTACTGCATTATGTCAGAAATTAAAGATACCAGATCATGTCAGAGAGAGAGCT
TGGTTAACTTGGGAGAAAGTTTCATCTGTGGATGGAGTATTGGGAGGTTATATTCAAAAGAAAAAGGAACTGTGGGGAATCTGTATCTTT
ATTGCAGCAGTTGACCTAGATGAGATGTCGTTCACTTTTACTGAGCTACAGAAAAACATAGAAATCAGTGTCCATAAATTCTTTAACTTA
CTAAAAGAAATTGATACCAGTACCAAAGTTGATAATGCTATGTCAAGACTGTTGAAGAAGTATGATGTATTGTTTGCACTCTTCAGCAAA
TTGGAAAGGACATGTGAACTTATATATTTGACACAACCCAGCAGTTCGATATCTACTGAAATAAATTCTGCATTGGTGCTAAAAGTTTCT
TGGATCACATTTTTATTAGCTAAAGGGGAAGTATTACAAATGGAAGATGATCTGGTGATTTCATTTCAGTTAATGCTATGTGTCCTTGAC
TATTTTATTAAACTCTCACCTCCCATGTTGCTCAAAGAACCATATAAAACAGCTGTTATACCCATTAATGGTTCACCTCGAACACCCAGG
CGAGGTCAGAACAGGAGTGCACGGATAGCAAAACAACTAGAAAATGATACAAGAATTATTGAAGTTCTCTGTAAAGAACATGAATGTAAT
ATAGATGAGGTGAAAAATGTTTATTTCAAAAATTTTATACCTTTTATGAATTCTCTTGGACTTGTAACATCTAATGGACTTCCAGAGGTT
GAAAATCTTTCTAAACGATACGAAGAAATTTATCTTAAAAATAAAGATCTAGATGCAAGATTATTTTTGGATCATGATAAAACTCTTCAG
ACTGATTCTATAGACAGTTTTGAAACACAGAGAACACCACGAAAAAGTAACCTTGATGAAGAGGTGAATGTAATTCCTCCACACACTCCA
GTTAGAGTCCAGGCAGAATATAATTCTATAAAGGGAACTCCTTCAGAGGCTGAAATCTTTACCACCTTGAGCTGTGAACCTGATATACCT
AATCCACCAAGGATAGCCAATCGGACCAAAAATTCACTCACTTTGCAATGGAAGGCACCTAGTGACAATGGTTCTAAAATCCAAAACTTT
GTATTAGAATGGGATGAAGGAAAAGGAAATGGAGAATTTTGTCAGTGTTACATGGGCTCACAGAAACAATTTAAAATTACTAAACTTTCA
CCAGCAATGGGCTGTAAATTCAGACTATCGGCCAGAAATGACTATGGTACAAGTGGTTTTAGTGAAGAAGTCTTATATTACACCTCAGGC
TGTGCTCCTTCTATGCCAGCAAGTCCTGTATTAACCAAGGCTGGAATTACTTGGTTATCCTTACAATGGAGTAAGCCCTCAGGAACACCA
TCAGATGAAGGAATTTCTTACATTTTAGAGATGGAGGAAGAAACTTCAGGATATGGTTTTAAGCCTAAATATGATGGAGAAGATCTTGCT
TACACAGTGAAAAATCTCAGACGTAGTACTAAGTATAAATTTAAGGTTATTGCTTACAACTCAGAAGGTAAAAGTAATCCAAGTGAAGTA
GTAGAATTTACTACTTGCCCTGATAAACCAGGCATACCTGTAAAGCCTTCAGTGAAAGGAAAGATACATTCACACAGTTTTAAAATAACC
TGGGATCCACCAAAAGACAATGGCGGAGCAACCATCAATAAATATGTAGTGGAGATGGCAGAAGGTTCTAACGGAAACAAATGGGAAATG
ATATACAGTGGTGCTACCAGGGAACATCTTTGTGATCGACTGAATCCAGGCTGTTTCTATCGTTTACGAGTTTACTGCATCAGTGATGGA
GGACAGAGTGCGGTCTCTGAATCTTTACTTGTGCAGACTCCAGCTGTGCCTCCTGGCCCATGCCTCCCTCCCAGATTACAGGGTAGACCC
AAAGCAAAAGAAATACAGTTACGATGGGGACCCCCTCTGGTTGATGGTGGATCACCCATTTCCTGTTACAGTGTGGAAATGTCTCCTATA
GAAAAAGATGAACCTAGAGAAGTTTACCAAGGTTCTGAAGTAGAATGTACAGTGAGCAGCCTTCTTCCTGGAAAGACATACAGCTTCAGA
CTACGTGCAGCTAACAAAATGGGGTTTGGACCATTTTCAGAAAAATGTGATATTACTACAGCCCCTGGGCCACCAGATCAGTGCAAGCCC
CCTCAAGTGACATGTAGATCTGCAACTTGTGCACAAGTGAATTGGGAGGTTCCTTTGAGTAATGGAACAGATGTCACTGAATATCGACTG
GAGTGGGGAGGAGTTGAAGGAAGTATGCAGATATGTTACTGTGGGCCTGGTCTCAGTTATGAAATAAAAGGACTTTCACCAGCAACTACC
TATTATTGCAGGGTCCAGGCTCTGAGTGTTGTGGGTGCAGGCCCTTTCAGTGAAGTAGTAGCCTGTGTGACTCCACCATCAGTTCCTGGC
ATTGTGACCTGTCTTCAAGAAATAAGCGATGATGAGATAGAAAATCCCCATTATTCACCTTCTACATGCCTTGCAATAAGCTGGGAAAAG
CCTTGTGATCATGGTTCGGAAATCCTTGCCTACAGCATAGACTTTGGAGATAAACAATCCCTAACAGTGGGAAAGGTTACAAGCTATATT
ATCAACAATTTGCAACCAGATACAACATACAGAATACGAATTCAAGCCTTGAATAGCCTTGGAGCTGGTCCTTTCAGCCATATGATAAAA
TTAAAAACTAAGCCTCTCCCTCCTGATCCACCTCGTCTGGAATGTGTTGCCTTTAGCCACCAGAACCTTAAGCTGAAATGGGGAGAAGGA
ACTCCAAAGACATTGTCAACCGATTCTATTCAGTACCACCTTCAGATGGAGGATAAGAATGGACGGTTTGTATCCCTATACAGAGGACCA
TGTCATACATACAAAGTACAAAGACTTAATGAGTCAACATCCTATAAATTCTGTATTCAAGCTTGTAATGAAGCTGGGGAAGGTCCCCTC
TCCCAAGAATATATTTTCACTACTCCAAAATCTGTCCCAGCTGCCTTGAAAGCCCCCAAAATAGAGAAAGTAAATGATCACATTTGTGAA
ATTACATGGGAGTGTTTACAGCCAATGAAAGGTGATCCAGTTATTTACAGTCTTCAAGTTATGTTGGGAAAAGATTCAGAATTCAAACAG
ATTTACAAGGGTCCCGACTCTTCCTTCCGGTATTCCAGCCTTCAGCTGAACTGTGAATATCGCTTCCGTGTATGTGCCATTCGCCAGTGC
CAAGACTCTCTGGGACACCAGGACCTCGTAGGTCCCTACAGCACCACAGTGCTCTTCATCTCTCAGAGGACTGAACCACCAGCCAGCACC
AACAGAGACACTGTGGAAAGCACAAGGACCCGACGGGCACTGAGTGACGAGCAGTGTGCTGCCGTCATCCTTGTGCTGTTTGCTTTCTTT
TCCATTTTGATTGCCTTTATCATTCAGTACTTTGTAATCAAGTGAAAATATAACTTTATTTTTTAACTCTATTACATTTTATTTTGTCAT
GTACTAAAATTATTTCTGTATTGCTTTTATAAAAAACAGTGGCATTTAGCACTGGCATTGAGACTATAGCACATCATTTTTGCCATTTTC
AGTGCTTATATTGTTAGGTAGAGGCTGGCACTTTATTAGAATGCAAGCCACAAAAATATCAATTTTGTTTTTTTTGTTAGGGTGGGTCTT
CTTTTTTTCTTTCCCTCTCTCTTTTTTTAACAAATGCCTTCTTATAGAAAAACTTTCTAAGAGGCAACAATTTAGAATGGATATTTTGAC
GAATCGGCATGAGTGTAACAGTGATAACCTGATCTGTTTGTTTTAAAGATTATTACCAAGTGAAAAATTCAGAATGAATAGAATTTACAC
TAACATGCTATATAAAATGTTAAAGTCTGATGCTGTGAAAGCAATCTAGTGCTATATTTCTACCTCCTCATTTGTCTTAATTATTTGGTA
AGTGGGATTATGATGAGTAACTGGAGGGGCTTAGAAACAAAAACTGGATGAAAGAGTATGCATGAAGAAAAGCTTCTTTGATAAATGTGG
AGTTCTTCATTATAAATATATATTCATGAATTCACAGATAAGTACTTAAAGAACAGACAGTTTACTTGGCCTAAAAATATTTTGATGTTT
ACTCAAAAAGTACCTCTTCAGGTCTTGAGAACATGGAAAAGAATTGAGTGCTTTTAAATACTTTTTAGAAAGTAATCATAAAAGTAAATT
GAATTTCAAACCTATTTGGCTTCTGTTTTGTGAACCTTTGAACTATATGTATGTGTATAAGGGTATACACATACATATATGGCATATAAC
AAGTGTACACATATACACATAACAAGTGTAGAAGTATATATTACATACATACACTCACTCTGTCTGGTATAGGCTAATTTTGAAGAACTC

>In-frame_ENST00000267163_ENST00000541916_TCGA-04-1365_RB1_chr13_48942740_+_FNDC3A_chr13_49742748_length(amino acids)=1228AA_start in transcript=138_stop in transcript=3824
MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFEETEEPDFTALCQKLKIPDHVRERAWLTWEKVSSVDGVLGG
YIQKKKELWGICIFIAAVDLDEMSFTFTELQKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSS
ISTEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYKTAVIPINGSPRTPRRGQNRSARIAKQLEND
TRIIEVLCKEHECNIDEVKNVYFKNFIPFMNSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKS
NLDEEVNVIPPHTPVRVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQC
YMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETS
GYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYV
VEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDG
GSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWE
VPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENP
HYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECV
AFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAAL
KAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTT

--------------------------------------------------------------
>In-frame_ENST00000267163_ENST00000398316_TCGA-04-1365_RB1_chr13_48942740_+_FNDC3A_chr13_49742748_length(transcript)=6023nt_BP=1265nt
TCCGGTTTTTCTCAGGGGACGTTGAAATTATTTTTGTAACGGGAGTCGGGAGAGGACGGGGCGTGCCCCGACGTGCGCGCGCGTCGTCCT
CCCCGGCGCTCCTCCACAGCTCGCTGGCTCCCGCCGCGGAAAGGCGTCATGCCGCCCAAAACCCCCCGAAAAACGGCCGCCACCGCCGCC
GCTGCCGCCGCGGAACCCCCGGCACCGCCGCCGCCGCCCCCTCCTGAGGAGGACCCAGAGCAGGACAGCGGCCCGGAGGACCTGCCTCTC
GTCAGGCTTGAGTTTGAAGAAACAGAAGAACCTGATTTTACTGCATTATGTCAGAAATTAAAGATACCAGATCATGTCAGAGAGAGAGCT
TGGTTAACTTGGGAGAAAGTTTCATCTGTGGATGGAGTATTGGGAGGTTATATTCAAAAGAAAAAGGAACTGTGGGGAATCTGTATCTTT
ATTGCAGCAGTTGACCTAGATGAGATGTCGTTCACTTTTACTGAGCTACAGAAAAACATAGAAATCAGTGTCCATAAATTCTTTAACTTA
CTAAAAGAAATTGATACCAGTACCAAAGTTGATAATGCTATGTCAAGACTGTTGAAGAAGTATGATGTATTGTTTGCACTCTTCAGCAAA
TTGGAAAGGACATGTGAACTTATATATTTGACACAACCCAGCAGTTCGATATCTACTGAAATAAATTCTGCATTGGTGCTAAAAGTTTCT
TGGATCACATTTTTATTAGCTAAAGGGGAAGTATTACAAATGGAAGATGATCTGGTGATTTCATTTCAGTTAATGCTATGTGTCCTTGAC
TATTTTATTAAACTCTCACCTCCCATGTTGCTCAAAGAACCATATAAAACAGCTGTTATACCCATTAATGGTTCACCTCGAACACCCAGG
CGAGGTCAGAACAGGAGTGCACGGATAGCAAAACAACTAGAAAATGATACAAGAATTATTGAAGTTCTCTGTAAAGAACATGAATGTAAT
ATAGATGAGGTGAAAAATGTTTATTTCAAAAATTTTATACCTTTTATGAATTCTCTTGGACTTGTAACATCTAATGGACTTCCAGAGGTT
GAAAATCTTTCTAAACGATACGAAGAAATTTATCTTAAAAATAAAGATCTAGATGCAAGATTATTTTTGGATCATGATAAAACTCTTCAG
ACTGATTCTATAGACAGTTTTGAAACACAGAGAACACCACGAAAAAGTAACCTTGATGAAGAGGTGAATGTAATTCCTCCACACACTCCA
GTTAGAGTCCAGGCAGAATATAATTCTATAAAGGGAACTCCTTCAGAGGCTGAAATCTTTACCACCTTGAGCTGTGAACCTGATATACCT
AATCCACCAAGGATAGCCAATCGGACCAAAAATTCACTCACTTTGCAATGGAAGGCACCTAGTGACAATGGTTCTAAAATCCAAAACTTT
GTATTAGAATGGGATGAAGGAAAAGGAAATGGAGAATTTTGTCAGTGTTACATGGGCTCACAGAAACAATTTAAAATTACTAAACTTTCA
CCAGCAATGGGCTGTAAATTCAGACTATCGGCCAGAAATGACTATGGTACAAGTGGTTTTAGTGAAGAAGTCTTATATTACACCTCAGGC
TGTGCTCCTTCTATGCCAGCAAGTCCTGTATTAACCAAGGCTGGAATTACTTGGTTATCCTTACAATGGAGTAAGCCCTCAGGAACACCA
TCAGATGAAGGAATTTCTTACATTTTAGAGATGGAGGAAGAAACTTCAGGATATGGTTTTAAGCCTAAATATGATGGAGAAGATCTTGCT
TACACAGTGAAAAATCTCAGACGTAGTACTAAGTATAAATTTAAGGTTATTGCTTACAACTCAGAAGGTAAAAGTAATCCAAGTGAAGTA
GTAGAATTTACTACTTGCCCTGATAAACCAGGCATACCTGTAAAGCCTTCAGTGAAAGGAAAGATACATTCACACAGTTTTAAAATAACC
TGGGATCCACCAAAAGACAATGGCGGAGCAACCATCAATAAATATGTAGTGGAGATGGCAGAAGGTTCTAACGGAAACAAATGGGAAATG
ATATACAGTGGTGCTACCAGGGAACATCTTTGTGATCGACTGAATCCAGGCTGTTTCTATCGTTTACGAGTTTACTGCATCAGTGATGGA
GGACAGAGTGCGGTCTCTGAATCTTTACTTGTGCAGACTCCAGCTGTGCCTCCTGGCCCATGCCTCCCTCCCAGATTACAGGGTAGACCC
AAAGCAAAAGAAATACAGTTACGATGGGGACCCCCTCTGGTTGATGGTGGATCACCCATTTCCTGTTACAGTGTGGAAATGTCTCCTATA
GAAAAAGATGAACCTAGAGAAGTTTACCAAGGTTCTGAAGTAGAATGTACAGTGAGCAGCCTTCTTCCTGGAAAGACATACAGCTTCAGA
CTACGTGCAGCTAACAAAATGGGGTTTGGACCATTTTCAGAAAAATGTGATATTACTACAGCCCCTGGGCCACCAGATCAGTGCAAGCCC
CCTCAAGTGACATGTAGATCTGCAACTTGTGCACAAGTGAATTGGGAGGTTCCTTTGAGTAATGGAACAGATGTCACTGAATATCGACTG
GAGTGGGGAGGAGTTGAAGGAAGTATGCAGATATGTTACTGTGGGCCTGGTCTCAGTTATGAAATAAAAGGACTTTCACCAGCAACTACC
TATTATTGCAGGGTCCAGGCTCTGAGTGTTGTGGGTGCAGGCCCTTTCAGTGAAGTAGTAGCCTGTGTGACTCCACCATCAGTTCCTGGC
ATTGTGACCTGTCTTCAAGAAATAAGCGATGATGAGATAGAAAATCCCCATTATTCACCTTCTACATGCCTTGCAATAAGCTGGGAAAAG
CCTTGTGATCATGGTTCGGAAATCCTTGCCTACAGCATAGACTTTGGAGATAAACAATCCCTAACAGTGGGAAAGGTTACAAGCTATATT
ATCAACAATTTGCAACCAGATACAACATACAGAATACGAATTCAAGCCTTGAATAGCCTTGGAGCTGGTCCTTTCAGCCATATGATAAAA
TTAAAAACTAAGCCTCTCCCTCCTGATCCACCTCGTCTGGAATGTGTTGCCTTTAGCCACCAGAACCTTAAGCTGAAATGGGGAGAAGGA
ACTCCAAAGACATTGTCAACCGATTCTATTCAGTACCACCTTCAGATGGAGGATAAGAATGGACGGTTTGTATCCCTATACAGAGGACCA
TGTCATACATACAAAGTACAAAGACTTAATGAGTCAACATCCTATAAATTCTGTATTCAAGCTTGTAATGAAGCTGGGGAAGGTCCCCTC
TCCCAAGAATATATTTTCACTACTCCAAAATCTGTCCCAGCTGCCTTGAAAGCCCCCAAAATAGAGAAAGTAAATGATCACATTTGTGAA
ATTACATGGGAGTGTTTACAGCCAATGAAAGGTGATCCAGTTATTTACAGTCTTCAAGTTATGTTGGGAAAAGATTCAGAATTCAAACAG
ATTTACAAGGGTCCCGACTCTTCCTTCCGGTATTCCAGCCTTCAGCTGAACTGTGAATATCGCTTCCGTGTATGTGCCATTCGCCAGTGC
CAAGACTCTCTGGGACACCAGGACCTCGTAGGTCCCTACAGCACCACAGTGCTCTTCATCTCTCAGAGGACTGAACCACCAGCCAGCACC
AACAGAGACACTGTGGAAAGCACAAGGACCCGACGGGCACTGAGTGACGAGCAGTGTGCTGCCGTCATCCTTGTGCTGTTTGCTTTCTTT
TCCATTTTGATTGCCTTTATCATTCAGTACTTTGTAATCAAGTGAAAATATAACTTTATTTTTTAACTCTATTACATTTTATTTTGTCAT
GTACTAAAATTATTTCTGTATTGCTTTTATAAAAAACAGTGGCATTTAGCACTGGCATTGAGACTATAGCACATCATTTTTGCCATTTTC
AGTGCTTATATTGTTAGGTAGAGGCTGGCACTTTATTAGAATGCAAGCCACAAAAATATCAATTTTGTTTTTTTTGTTAGGGTGGGTCTT
CTTTTTTTCTTTCCCTCTCTCTTTTTTTAACAAATGCCTTCTTATAGAAAAACTTTCTAAGAGGCAACAATTTAGAATGGATATTTTGAC
GAATCGGCATGAGTGTAACAGTGATAACCTGATCTGTTTGTTTTAAAGATTATTACCAAGTGAAAAATTCAGAATGAATAGAATTTACAC
TAACATGCTATATAAAATGTTAAAGTCTGATGCTGTGAAAGCAATCTAGTGCTATATTTCTACCTCCTCATTTGTCTTAATTATTTGGTA
AGTGGGATTATGATGAGTAACTGGAGGGGCTTAGAAACAAAAACTGGATGAAAGAGTATGCATGAAGAAAAGCTTCTTTGATAAATGTGG
AGTTCTTCATTATAAATATATATTCATGAATTCACAGATAAGTACTTAAAGAACAGACAGTTTACTTGGCCTAAAAATATTTTGATGTTT
ACTCAAAAAGTACCTCTTCAGGTCTTGAGAACATGGAAAAGAATTGAGTGCTTTTAAATACTTTTTAGAAAGTAATCATAAAAGTAAATT
GAATTTCAAACCTATTTGGCTTCTGTTTTGTGAACCTTTGAACTATATGTATGTGTATAAGGGTATACACATACATATATGGCATATAAC
AAGTGTACACATATACACATAACAAGTGTAGAAGTATATATTACATACATACACTCACTCTGTCTGGTATAGGCTAATTTTGAAGAACTC
CCATAAGTTTCTGCTGCTTCTCCCATAACTGCTGCCACCACCATCAGAATTCATAATCAAACCTAACCTTTTTGTTTGGGGCACCAAATC
TGAAGACAAAATTAATTTGCACCAGTAAACTTCAAGCTGCTTTCTTTCTTGAAAACTAAACGTTTAACGTATAATGTCTGTTTGGATACT
GTTCCAAATTGTTGATTGCATGTGGTTAATGTTGCATTAGAGCACTTTGCAATTGCATAATTCATTAATGTTTTGTGAGCTTGCATTTGT
GAGTTATTGGATGATCAGACTGAATTTTGTCAAGTATCACATTGTACATCTTGCCTAGATGTCGATGACTGCAAGTAATAATACAGTTTA
TAATGAAACTATCTACAATTCTTGTTTTAGCACATCTGTTATCCGTAAAACACCTGTAACTAGCTTTTTTAATTTATTATTTGAATTTTA
GGATAGCGAATCACTAATTTTTAGTTGCTGAGGTTGGCATTTTAGTGATTATTAAGCACTTCTGTCAGTCTTTGAAAAAAGAACGTATTT
TTTGTGCTTTGAAGATCTCTGAAGAATTTCTTTTATAATAGAATGGGCATGTATTGTAACAGTTTTATGTCAAATGATCTGTGCTGTAGA
AAAACATTAACCCTTGTTCAAAAAAGAAATGGATAAACTTGGCCTTTCTAAGTGGTAAGAATGACCTGTCACTATAATATACTGTATGTT
TACATTTTATTTAAATTTAATCTCTTATGTATAGGGTGATAACCTTCCCCAGAAACAACAGTGATTGCGATTGTTTTCTAGAAACTTCTT
TAAAGTGCCACATTTGGCAGTACAAATGAGTCTGAGTGTAATAGCCCAGAGATTTATATATAGTTGAATGTCTAAAATGGTAAAATGTGC
CACTGTGTCAAGTTACAGTGGCTTATGTTTTTCATAGTAATTCAAATGAACTTCCTATTTTTGATAGTAAATGTCATTTAATAGTATACT
TGCCATTTGAGCCTCACTGCAAAATTAGTGCAGAGGAGAAAACAATTTTTAATGTAATCTTGATTTTACCTCATATACTGTACATTCCAA
AAACTCTAAACTTTTTAAAGATTATAGATACACTACCAAACATATCACCTTAAAATTGTATAAGGCTGAATGAACTTCATACAAATGAAA

>In-frame_ENST00000267163_ENST00000398316_TCGA-04-1365_RB1_chr13_48942740_+_FNDC3A_chr13_49742748_length(amino acids)=1228AA_start in transcript=138_stop in transcript=3824
MPPKTPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFEETEEPDFTALCQKLKIPDHVRERAWLTWEKVSSVDGVLGG
YIQKKKELWGICIFIAAVDLDEMSFTFTELQKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSS
ISTEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYKTAVIPINGSPRTPRRGQNRSARIAKQLEND
TRIIEVLCKEHECNIDEVKNVYFKNFIPFMNSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKS
NLDEEVNVIPPHTPVRVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQC
YMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETS
GYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYV
VEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDG
GSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWE
VPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQEISDDEIENP
HYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECV
AFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAGEGPLSQEYIFTTPKSVPAAL
KAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for RB1-FNDC3A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRB1chr13:48942740chr13:49742748ENST00000267163+1127763_928375.6666666666667929.0LIMD1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RB1-FNDC3A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RB1-FNDC3A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRB1C0035335Retinoblastoma15CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneRB1C0006142Malignant neoplasm of breast3CGI;CTD_human
HgeneRB1C0149925Small cell carcinoma of lung3CGI;CTD_human;ORPHANET
HgeneRB1C0678222Breast Carcinoma3CGI;CTD_human
HgeneRB1C0751483Familial Retinoblastoma3CTD_human;ORPHANET
HgeneRB1C1257931Mammary Neoplasms, Human3CTD_human
HgeneRB1C1458155Mammary Neoplasms3CTD_human
HgeneRB1C4704874Mammary Carcinoma, Human3CTD_human
HgeneRB1C0029463Osteosarcoma2CTD_human;ORPHANET
HgeneRB1C2239176Liver carcinoma2CTD_human
HgeneRB1C0001624Adrenal Gland Neoplasms1CTD_human
HgeneRB1C0007097Carcinoma1CTD_human
HgeneRB1C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneRB1C0007786Brain Ischemia1CTD_human
HgeneRB1C0014518Toxic Epidermal Necrolysis1CTD_human
HgeneRB1C0019207Hepatoma, Morris1CTD_human
HgeneRB1C0019208Hepatoma, Novikoff1CTD_human
HgeneRB1C0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
HgeneRB1C0023453L2 Acute Lymphoblastic Leukemia1CTD_human
HgeneRB1C0023904Liver Neoplasms, Experimental1CTD_human
HgeneRB1C0024667Animal Mammary Neoplasms1CTD_human
HgeneRB1C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneRB1C0027627Neoplasm Metastasis1CTD_human
HgeneRB1C0027659Neoplasms, Experimental1CTD_human
HgeneRB1C0030297Pancreatic Neoplasm1CTD_human
HgeneRB1C0033578Prostatic Neoplasms1CTD_human
HgeneRB1C0036920Sezary Syndrome1CTD_human
HgeneRB1C0038325Stevens-Johnson Syndrome1CTD_human
HgeneRB1C0086404Experimental Hepatoma1CTD_human
HgeneRB1C0205696Anaplastic carcinoma1CTD_human
HgeneRB1C0205697Carcinoma, Spindle-Cell1CTD_human
HgeneRB1C0205698Undifferentiated carcinoma1CTD_human
HgeneRB1C0205699Carcinomatosis1CTD_human
HgeneRB1C0206686Adrenocortical carcinoma1CTD_human
HgeneRB1C0238198Gastrointestinal Stromal Tumors1CTD_human
HgeneRB1C0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneRB1C0346647Malignant neoplasm of pancreas1CTD_human
HgeneRB1C0376358Malignant neoplasm of prostate1CTD_human
HgeneRB1C0750887Adrenal Cancer1CTD_human
HgeneRB1C0917798Cerebral Ischemia1CTD_human
HgeneRB1C1257925Mammary Carcinoma, Animal1CTD_human
HgeneRB1C1274933Drug-Induced Stevens Johnson Syndrome1CTD_human
HgeneRB1C1368275Pigmented Basal Cell Carcinoma1CTD_human
HgeneRB1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
HgeneRB1C2608045Trilateral Retinoblastoma1GENOMICS_ENGLAND
HgeneRB1C2930974Acute erythroleukemia1CTD_human
HgeneRB1C2930975Acute erythroleukemia - M6a subtype1CTD_human
HgeneRB1C2930976Acute myeloid leukemia FAB-M61CTD_human
HgeneRB1C2930977Acute erythroleukemia - M6b subtype1CTD_human
HgeneRB1C3151302Chromosome 13q14 deletion syndrome1ORPHANET
HgeneRB1C3179349Gastrointestinal Stromal Sarcoma1CTD_human
HgeneRB1C3658301Mycoplasma-Induced Stevens-Johnson Syndrome1CTD_human
HgeneRB1C3658302Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum1CTD_human
HgeneRB1C4721806Carcinoma, Basal Cell1CTD_human