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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RBM14-ARHGAP32 (FusionGDB2 ID:72316)

Fusion Gene Summary for RBM14-ARHGAP32

check button Fusion gene summary
Fusion gene informationFusion gene name: RBM14-ARHGAP32
Fusion gene ID: 72316
HgeneTgene
Gene symbol

RBM14

ARHGAP32

Gene ID

100526737

9743

Gene nameRBM14-RBM4 readthroughRho GTPase activating protein 32
SynonymsCOAZ|PSP2|RBM14|SIPGC-GAP|GRIT|PX-RICS|RICS|p200RhoGAP|p250GAP
Cytomap

11q13.2

11q24.3

Type of geneprotein-codingprotein-coding
DescriptionRBM14-RBM4 proteinParaspeckle protein 2RBM14/RBM4 fusionRNA-binding motif protein 14RNA-binding protein 14RRM-containing coactivator activator/modulatorSYT-interacting proteinSynaptotagmin-interacting proteintranscriptional coactivator CoAZrho GTPase-activating protein 32GAB-associated CDC42GAB-associated Cdc42/Rac GTPase-activating proteinGTPase regulator interacting with TrkAGTPase-activating protein for Cdc42 and Rac1RhoGAP involved in the -catenin-N-cadherin and NMDA receptor signa
Modification date2020031320200327
UniProtAcc.

A7KAX9

Ensembl transtripts involved in fusion geneENST00000310137, ENST00000393979, 
ENST00000409372, ENST00000443702, 
ENST00000409738, ENST00000461478, 
ENST00000310343, ENST00000524655, 
ENST00000392657, ENST00000527272, 
Fusion gene scores* DoF score12 X 5 X 10=6007 X 6 X 5=210
# samples 137
** MAII scorelog2(13/600*10)=-2.20645087746743
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RBM14 [Title/Abstract] AND ARHGAP32 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRBM14(66384528)-ARHGAP32(128994789), # samples:1
Anticipated loss of major functional domain due to fusion event.RBM14-ARHGAP32 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
RBM14-ARHGAP32 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RBM14-ARHGAP32 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RBM14 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ARHGAP32 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-LN-A4MRRBM14chr11

66384528

+ARHGAP32chr11

128994789

-


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Fusion Gene ORF analysis for RBM14-ARHGAP32

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000310137ENST00000310343RBM14chr11

66384528

+ARHGAP32chr11

128994789

-
Frame-shiftENST00000310137ENST00000524655RBM14chr11

66384528

+ARHGAP32chr11

128994789

-
5CDS-intronENST00000310137ENST00000392657RBM14chr11

66384528

+ARHGAP32chr11

128994789

-
5CDS-intronENST00000310137ENST00000527272RBM14chr11

66384528

+ARHGAP32chr11

128994789

-
Frame-shiftENST00000393979ENST00000310343RBM14chr11

66384528

+ARHGAP32chr11

128994789

-
Frame-shiftENST00000393979ENST00000524655RBM14chr11

66384528

+ARHGAP32chr11

128994789

-
5CDS-intronENST00000393979ENST00000392657RBM14chr11

66384528

+ARHGAP32chr11

128994789

-
5CDS-intronENST00000393979ENST00000527272RBM14chr11

66384528

+ARHGAP32chr11

128994789

-
Frame-shiftENST00000409372ENST00000310343RBM14chr11

66384528

+ARHGAP32chr11

128994789

-
Frame-shiftENST00000409372ENST00000524655RBM14chr11

66384528

+ARHGAP32chr11

128994789

-
5CDS-intronENST00000409372ENST00000392657RBM14chr11

66384528

+ARHGAP32chr11

128994789

-
5CDS-intronENST00000409372ENST00000527272RBM14chr11

66384528

+ARHGAP32chr11

128994789

-
Frame-shiftENST00000443702ENST00000310343RBM14chr11

66384528

+ARHGAP32chr11

128994789

-
Frame-shiftENST00000443702ENST00000524655RBM14chr11

66384528

+ARHGAP32chr11

128994789

-
5CDS-intronENST00000443702ENST00000392657RBM14chr11

66384528

+ARHGAP32chr11

128994789

-
5CDS-intronENST00000443702ENST00000527272RBM14chr11

66384528

+ARHGAP32chr11

128994789

-
Frame-shiftENST00000409738ENST00000310343RBM14chr11

66384528

+ARHGAP32chr11

128994789

-
Frame-shiftENST00000409738ENST00000524655RBM14chr11

66384528

+ARHGAP32chr11

128994789

-
5CDS-intronENST00000409738ENST00000392657RBM14chr11

66384528

+ARHGAP32chr11

128994789

-
5CDS-intronENST00000409738ENST00000527272RBM14chr11

66384528

+ARHGAP32chr11

128994789

-
intron-3CDSENST00000461478ENST00000310343RBM14chr11

66384528

+ARHGAP32chr11

128994789

-
intron-3CDSENST00000461478ENST00000524655RBM14chr11

66384528

+ARHGAP32chr11

128994789

-
intron-intronENST00000461478ENST00000392657RBM14chr11

66384528

+ARHGAP32chr11

128994789

-
intron-intronENST00000461478ENST00000527272RBM14chr11

66384528

+ARHGAP32chr11

128994789

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for RBM14-ARHGAP32


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RBM14-ARHGAP32


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ARHGAP32

A7KAX9

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for RBM14-ARHGAP32


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for RBM14-ARHGAP32


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RBM14-ARHGAP32


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RBM14-ARHGAP32


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneARHGAP32C0036341Schizophrenia1PSYGENET