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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:RBM6-RHOT2 (FusionGDB2 ID:72531) |
Fusion Gene Summary for RBM6-RHOT2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: RBM6-RHOT2 | Fusion gene ID: 72531 | Hgene | Tgene | Gene symbol | RBM6 | RHOT2 | Gene ID | 10180 | 89941 |
Gene name | RNA binding motif protein 6 | ras homolog family member T2 | |
Synonyms | 3G2|DEF-3|DEF3|HLC-11|NY-LU-12|g16 | ARHT2|C16orf39|MIRO-2|MIRO2|RASL | |
Cytomap | 3p21.31 | 16p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | RNA-binding protein 6RNA-binding protein DEF-3lung cancer antigen NY-LU-12lung cancer protooncogene 11 | mitochondrial Rho GTPase 2mitochondrial Rho (MIRO) GTPase 2ras homolog gene family, member T2 | |
Modification date | 20200313 | 20200320 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000442092, ENST00000266022, ENST00000443081, ENST00000539992, ENST00000441115, ENST00000422955, ENST00000421682, | ENST00000315082, ENST00000569943, | |
Fusion gene scores | * DoF score | 31 X 22 X 13=8866 | 7 X 8 X 5=280 |
# samples | 31 | 8 | |
** MAII score | log2(31/8866*10)=-4.83794324189103 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: RBM6 [Title/Abstract] AND RHOT2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | RBM6(50036946)-RHOT2(720123), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene breakpoints across RBM6 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across RHOT2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | UCEC | TCGA-AX-A2H5-01A | RBM6 | chr3 | 50036946 | + | RHOT2 | chr16 | 720123 | + |
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Fusion Gene ORF analysis for RBM6-RHOT2 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000442092 | ENST00000315082 | RBM6 | chr3 | 50036946 | + | RHOT2 | chr16 | 720123 | + |
intron-3UTR | ENST00000442092 | ENST00000569943 | RBM6 | chr3 | 50036946 | + | RHOT2 | chr16 | 720123 | + |
In-frame | ENST00000266022 | ENST00000315082 | RBM6 | chr3 | 50036946 | + | RHOT2 | chr16 | 720123 | + |
5CDS-3UTR | ENST00000266022 | ENST00000569943 | RBM6 | chr3 | 50036946 | + | RHOT2 | chr16 | 720123 | + |
In-frame | ENST00000443081 | ENST00000315082 | RBM6 | chr3 | 50036946 | + | RHOT2 | chr16 | 720123 | + |
5CDS-3UTR | ENST00000443081 | ENST00000569943 | RBM6 | chr3 | 50036946 | + | RHOT2 | chr16 | 720123 | + |
intron-3CDS | ENST00000539992 | ENST00000315082 | RBM6 | chr3 | 50036946 | + | RHOT2 | chr16 | 720123 | + |
intron-3UTR | ENST00000539992 | ENST00000569943 | RBM6 | chr3 | 50036946 | + | RHOT2 | chr16 | 720123 | + |
3UTR-3CDS | ENST00000441115 | ENST00000315082 | RBM6 | chr3 | 50036946 | + | RHOT2 | chr16 | 720123 | + |
3UTR-3UTR | ENST00000441115 | ENST00000569943 | RBM6 | chr3 | 50036946 | + | RHOT2 | chr16 | 720123 | + |
intron-3CDS | ENST00000422955 | ENST00000315082 | RBM6 | chr3 | 50036946 | + | RHOT2 | chr16 | 720123 | + |
intron-3UTR | ENST00000422955 | ENST00000569943 | RBM6 | chr3 | 50036946 | + | RHOT2 | chr16 | 720123 | + |
intron-3CDS | ENST00000421682 | ENST00000315082 | RBM6 | chr3 | 50036946 | + | RHOT2 | chr16 | 720123 | + |
intron-3UTR | ENST00000421682 | ENST00000569943 | RBM6 | chr3 | 50036946 | + | RHOT2 | chr16 | 720123 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000266022 | RBM6 | chr3 | 50036946 | + | ENST00000315082 | RHOT2 | chr16 | 720123 | + | 3965 | 1816 | 259 | 3396 | 1045 |
ENST00000443081 | RBM6 | chr3 | 50036946 | + | ENST00000315082 | RHOT2 | chr16 | 720123 | + | 4229 | 2080 | 859 | 3660 | 933 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000266022 | ENST00000315082 | RBM6 | chr3 | 50036946 | + | RHOT2 | chr16 | 720123 | + | 0.001870523 | 0.99812955 |
ENST00000443081 | ENST00000315082 | RBM6 | chr3 | 50036946 | + | RHOT2 | chr16 | 720123 | + | 0.002103217 | 0.9978968 |
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Fusion Genomic Features for RBM6-RHOT2 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
RBM6 | chr3 | 50036946 | + | RHOT2 | chr16 | 720122 | + | 5.00E-07 | 0.9999995 |
RBM6 | chr3 | 50036946 | + | RHOT2 | chr16 | 720122 | + | 5.00E-07 | 0.9999995 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for RBM6-RHOT2 |
Go to FGviewer for the breakpoints of chr3:50036946-chr16:720123 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | RHOT2 | chr3:50036946 | chr16:720123 | ENST00000315082 | 4 | 19 | 197_208 | 92.0 | 619.0 | Calcium binding | 1 | |
Tgene | RHOT2 | chr3:50036946 | chr16:720123 | ENST00000315082 | 4 | 19 | 317_328 | 92.0 | 619.0 | Calcium binding | 2 | |
Tgene | RHOT2 | chr3:50036946 | chr16:720123 | ENST00000315082 | 4 | 19 | 184_219 | 92.0 | 619.0 | Domain | EF-hand 1 | |
Tgene | RHOT2 | chr3:50036946 | chr16:720123 | ENST00000315082 | 4 | 19 | 304_339 | 92.0 | 619.0 | Domain | EF-hand 2 | |
Tgene | RHOT2 | chr3:50036946 | chr16:720123 | ENST00000315082 | 4 | 19 | 414_576 | 92.0 | 619.0 | Domain | Miro 2 | |
Tgene | RHOT2 | chr3:50036946 | chr16:720123 | ENST00000315082 | 4 | 19 | 118_121 | 92.0 | 619.0 | Nucleotide binding | GTP 1 | |
Tgene | RHOT2 | chr3:50036946 | chr16:720123 | ENST00000315082 | 4 | 19 | 423_430 | 92.0 | 619.0 | Nucleotide binding | GTP 2 | |
Tgene | RHOT2 | chr3:50036946 | chr16:720123 | ENST00000315082 | 4 | 19 | 459_463 | 92.0 | 619.0 | Nucleotide binding | GTP 2 | |
Tgene | RHOT2 | chr3:50036946 | chr16:720123 | ENST00000315082 | 4 | 19 | 524_527 | 92.0 | 619.0 | Nucleotide binding | GTP 2 | |
Tgene | RHOT2 | chr3:50036946 | chr16:720123 | ENST00000315082 | 4 | 19 | 616_618 | 92.0 | 619.0 | Topological domain | Mitochondrial intermembrane | |
Tgene | RHOT2 | chr3:50036946 | chr16:720123 | ENST00000315082 | 4 | 19 | 593_615 | 92.0 | 619.0 | Transmembrane | Helical%3B Anchor for type IV membrane protein |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | RBM6 | chr3:50036946 | chr16:720123 | ENST00000266022 | + | 6 | 21 | 826_829 | 519.0 | 1124.0 | Compositional bias | Note=Poly-Glu |
Hgene | RBM6 | chr3:50036946 | chr16:720123 | ENST00000266022 | + | 6 | 21 | 892_895 | 519.0 | 1124.0 | Compositional bias | Note=Poly-Pro |
Hgene | RBM6 | chr3:50036946 | chr16:720123 | ENST00000266022 | + | 6 | 21 | 915_921 | 519.0 | 1124.0 | Compositional bias | Note=Poly-Glu |
Hgene | RBM6 | chr3:50036946 | chr16:720123 | ENST00000422955 | + | 1 | 19 | 826_829 | 0 | 602.0 | Compositional bias | Note=Poly-Glu |
Hgene | RBM6 | chr3:50036946 | chr16:720123 | ENST00000422955 | + | 1 | 19 | 892_895 | 0 | 602.0 | Compositional bias | Note=Poly-Pro |
Hgene | RBM6 | chr3:50036946 | chr16:720123 | ENST00000422955 | + | 1 | 19 | 915_921 | 0 | 602.0 | Compositional bias | Note=Poly-Glu |
Hgene | RBM6 | chr3:50036946 | chr16:720123 | ENST00000442092 | + | 1 | 17 | 826_829 | 0 | 602.0 | Compositional bias | Note=Poly-Glu |
Hgene | RBM6 | chr3:50036946 | chr16:720123 | ENST00000442092 | + | 1 | 17 | 892_895 | 0 | 602.0 | Compositional bias | Note=Poly-Pro |
Hgene | RBM6 | chr3:50036946 | chr16:720123 | ENST00000442092 | + | 1 | 17 | 915_921 | 0 | 602.0 | Compositional bias | Note=Poly-Glu |
Hgene | RBM6 | chr3:50036946 | chr16:720123 | ENST00000266022 | + | 6 | 21 | 1051_1097 | 519.0 | 1124.0 | Domain | G-patch |
Hgene | RBM6 | chr3:50036946 | chr16:720123 | ENST00000266022 | + | 6 | 21 | 456_536 | 519.0 | 1124.0 | Domain | RRM |
Hgene | RBM6 | chr3:50036946 | chr16:720123 | ENST00000422955 | + | 1 | 19 | 1051_1097 | 0 | 602.0 | Domain | G-patch |
Hgene | RBM6 | chr3:50036946 | chr16:720123 | ENST00000422955 | + | 1 | 19 | 456_536 | 0 | 602.0 | Domain | RRM |
Hgene | RBM6 | chr3:50036946 | chr16:720123 | ENST00000442092 | + | 1 | 17 | 1051_1097 | 0 | 602.0 | Domain | G-patch |
Hgene | RBM6 | chr3:50036946 | chr16:720123 | ENST00000442092 | + | 1 | 17 | 456_536 | 0 | 602.0 | Domain | RRM |
Tgene | RHOT2 | chr3:50036946 | chr16:720123 | ENST00000315082 | 4 | 19 | 2_168 | 92.0 | 619.0 | Domain | Miro 1 | |
Tgene | RHOT2 | chr3:50036946 | chr16:720123 | ENST00000315082 | 4 | 19 | 11_18 | 92.0 | 619.0 | Nucleotide binding | GTP 1 | |
Tgene | RHOT2 | chr3:50036946 | chr16:720123 | ENST00000315082 | 4 | 19 | 57_61 | 92.0 | 619.0 | Nucleotide binding | GTP 1 | |
Tgene | RHOT2 | chr3:50036946 | chr16:720123 | ENST00000315082 | 4 | 19 | 1_592 | 92.0 | 619.0 | Topological domain | Cytoplasmic |
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Fusion Gene Sequence for RBM6-RHOT2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000266022_ENST00000315082_TCGA-AX-A2H5-01A_RBM6_chr3_50036946_+_RHOT2_chr16_720123_length(transcript)=3965nt_BP=1816nt ACGGCGGGAGTAAGAGTCTGCGGGACCGGCAGCTGTACTTCATCTCCCAGCGGGCCGAGCGCTGAAGGCAGCGGCGCGGCGCCTTTGTGG TAGCAGTGGCCCCGCGCGGAGGAAGTTCCGGTGTCCGCGGCGCTGGGTCGGTGGCGGAGGCTGAGGAGAAGGAGGAGCGGGCCGTGGAGG CTTCGCCGCCTAGGTACTGCTATAACCAGAATTTGGTAGAAAAAGGATTTACTTGTTGGGGCCCTCTTGATAAAAAGAGATGTGGGGGGA TTCTCGACCTGCTAACAGAACTGGACCTTTTCGTGGGAGCCAAGAAGAAAGGTTTGCTCCCGGGTGGAACAGGGATTATCCTCCTCCTCC CCTTAAGAGTCATGCTCAAGAGAGACACTCTGGCAACTTTCCTGGCAGAGATTCACTTCCCTTTGATTTCCAGGGGCATTCGGGGCCTCC TTTTGCAAATGTAGAGGAGCATTCTTTCAGCTATGGAGCTAGAGACGGACCGCATGGTGACTATCGAGGAGGGGAGGGACCTGGACATGA TTTCAGGGGGGGAGATTTTTCGTCTTCTGATTTCCAGAGCAGAGATTCATCACAGTTGGACTTCAGGGGTAGGGACATACATTCTGGGGA TTTTCGGGATAGAGAAGGACCACCTATGGACTATAGGGGTGGAGATGGTACTTCTATGGATTATAGAGGTAGGGAGGCACCTCATATGAA CTACAGAGACAGGGATGCTCACGCTGTTGACTTCAGAGGTAGGGATGCTCCTCCATCTGACTTCAGGGGCCGGGGCACTTATGATTTAGA TTTTAGAGGCCGGGATGGATCCCATGCAGATTTTAGGGGAAGGGATTTATCAGATTTGGATTTTAGGGCCAGAGAACAGTCCCGTTCTGA TTTTAGGAATAGAGATGTATCTGATTTGGACTTTAGAGACAAAGACGGAACACAAGTAGACTTTAGAGGCCGAGGTTCAGGTACTACTGA TCTAGACTTTAGGGACAGGGATACGCCACATTCAGATTTCAGAGGTAGACACCGATCTAGGACTGATCAGGATTTTAGGGGCAGAGAGAT GGGATCTTGTATGGAATTTAAAGATAGGGAGATGCCCCCTGTGGATCCAAATATTTTGGATTACATTCAGCCCTCTACACAAGATAGAGA ACATTCTGGTATGAATGTGAACAGGAGAGAAGAATCCACACATGACCATACGATAGAAAGGCCTGCTTTTGGCATTCAGAAGGGAGAATT TGAGCATTCAGAAACAAGAGAAGGAGAAACACAAGGTGTAGCCTTTGAACATGAGTCTCCAGCAGACTTTCAGAACAGCCAAAGTCCAGT TCAAGACCAAGATAAGTCACAGCTTTCTGGACGTGAAGAGCAGAGTTCAGATGCTGGTCTGTTTAAAGAAGAAGGCGGTCTGGACTTTCT TGGGCGGCAAGACACCGATTACAGAAGCATGGAGTACCGTGATGTGGATCATAGGCTGCCAGGAAGCCAGATGTTTGGCTATGGCCAGAG CAAGTCTTTTCCAGAGGGCAAAACTGCCCGAGATGCCCAACGGGACCTTCAGGATCAAGATTATAGGACCGGCCCAAGTGAGGAGAAACC CAGCAGGCTTATTCGATTAAGTGGGGTACCTGAAGATGCCACAAAAGAAGAGATTCTTAATGCTTTTCGGACTCCTGATGGCATGCCTGT AAAGAACTTGCAGTTGAAGGAGTATAACACAGGTTACGACTATGGCTATGTCTGCGTGGAGTTTTCACTCTTGGAAGATGCCATCGGATG CATGGAGGCCAACCAGATTCGAACTAAGTGGATCCCACTGGTGAATGGGGGGACCACGCAGGGGCCCAGGGTGCCCATCATCCTAGTGGG CAACAAGTCAGACCTGCGGTCGGGGAGCTCCATGGAGGCCGTGCTCCCCATCATGAGCCAGTTTCCCGAGATTGAGACCTGCGTGGAGTG TTCGGCCAAGAACCTGAGGAACATCTCAGAGCTGTTCTACTACGCCCAGAAGGCCGTCCTGCATCCCACAGCCCCCCTCTATGACCCTGA GGCCAAGCAGTTGAGGCCCGCGTGCGCCCAGGCGCTGACGCGCATCTTCAGGCTCTCAGATCAGGACCTGGACCAGGCGCTCAGTGACGA AGAGCTCAACGCTTTCCAGAAATCCTGCTTTGGGCACCCCCTGGCCCCGCAGGCCCTGGAGGACGTGAAGACGGTGGTGTGCAGGAACGT GGCGGGCGGCGTGCGGGAGGACCGGCTGACCCTGGATGGTTTCCTCTTCCTGAACACGCTCTTCATCCAGCGCGGCCGGCACGAGACCAC CTGGACCATCCTGCGGCGCTTCGGCTACAGCGATGCCCTGGAGCTGACTGCGGACTATCTCTCCCCTCTGATCCACGTGCCCCCCGGCTG CAGCACGGAGCTCAACCACCTTGGCTACCAGTTTGTGCAGAGAGTGTTTGAGAAGCACGACCAGGACCGCGACGGCGCCCTCTCGCCCGT GGAGCTGCAAAGCCTTTTCAGTGTGTTCCCAGCAGCGCCCTGGGGCCCCGAGCTCCCACGCACAGTCCGCACAGAGGCCGGCCGGTTGCC CCTGCACGGATACCTCTGCCAGTGGACCCTGGTGACCTACCTGGACGTCCGGAGCTGCCTTGGACACCTAGGCTACCTGGGCTACCCCAC CCTCTGTGAGCAGGACCAGGCCCATGCCATCACAGTCACTCGTGAGAAGAGGCTGGACCAGGAGAAGGGACAGACGCAGCGGAGCGTCCT CCTGTGCAAGGTGGTAGGGGCCCGTGGAGTGGGCAAGTCTGCCTTCCTGCAGGCCTTTCTCGGCCGCGGCCTGGGGCACCAGGACACGAG GGAGCAGCCTCCCGGCTACGCCATCGACACGGTGCAGGTCAATGGACAGGAGAAGTACTTGATCCTCTGTGAGGTGGGCACAGATGGTCT GCTGGCCACATCGCTGGACGCCACCTGTGACGTTGCCTGCTTGATGTTTGATGGCAGTGACCCAAAGTCCTTTGCACATTGTGCCAGCGT CTACAAGCACCATTACATGGACGGGCAGACCCCCTGCCTCTTTGTCTCCTCCAAGGCCGACCTGCCCGAAGGTGTCGCGGTGTCTGGCCC ATCACCGGCCGAGTTTTGCCGCAAGCACCGGCTACCCGCTCCCGTGCCGTTCTCCTGTGCTGGCCCAGCCGAGCCCAGCACCACCATCTT CACCCAGCTCGCCACCATGGCCGCCTTCCCACATTTGGTCCACGCAGAGCTGCATCCCTCTTCCTTCTGGCTCCGGGGGCTGCTGGGGGT TGTCGGGGCCGCCGTGGCCGCAGTCCTCAGCTTCTCACTCTACAGGGTCCTGGTGAAGAGCCAGTGAGGCCCCTGGTACCCAAGCCCCCT CCCCTGACCTGGGTGTGCCTCGCTGCTGGGGCTCTGCAGGGGCAGCACAGCTGGGGTGCAGGCCAGGCTGCCACTCCGGGAACGCCTTTG CGCCGGGACTTTTTGTTTCTGAAGGCAGTCGATCTGCAGCGGGGCCTTATGCTGCCATGCACTGCCCTGGCTCCTGCCGGACCCCCAGGG TGGGCCGTGGCAGGTGGCTGAGCAGGAGCTCCCAAGTGCCGGCCACCGCTGTCAGGGATTGCCCACCCCTGGGCATCATGTGTGTGGGGC CGGGGAGCACAGGTGTGGGAGCTGGTGACCCCAGACCCAGAATTCTCAGGGCTCTACCCCCCTTTCCTGGTCCTAGGTGGCCAGTGGGTA TGAGGAGGGCTGGAAGGCAGAGCTTTGGGCCAAAAGCAGGCGTTGGGGGGTCCCCCCTCAAGTTTGGAGCCGTTTCCGTGGTTGTAGCAG AGGACCGGAGGTTGGGTTCCTGATTAAACTTCACTGTGTGTTTTCTATCTCGGATCCCAGTCTCTGAAGACAACTTGCTTTGATTCAACC >In-frame_ENST00000266022_ENST00000315082_TCGA-AX-A2H5-01A_RBM6_chr3_50036946_+_RHOT2_chr16_720123_length(amino acids)=1045AA_start in transcript=259_stop in transcript=3396 MWGDSRPANRTGPFRGSQEERFAPGWNRDYPPPPLKSHAQERHSGNFPGRDSLPFDFQGHSGPPFANVEEHSFSYGARDGPHGDYRGGEG PGHDFRGGDFSSSDFQSRDSSQLDFRGRDIHSGDFRDREGPPMDYRGGDGTSMDYRGREAPHMNYRDRDAHAVDFRGRDAPPSDFRGRGT YDLDFRGRDGSHADFRGRDLSDLDFRAREQSRSDFRNRDVSDLDFRDKDGTQVDFRGRGSGTTDLDFRDRDTPHSDFRGRHRSRTDQDFR GREMGSCMEFKDREMPPVDPNILDYIQPSTQDREHSGMNVNRREESTHDHTIERPAFGIQKGEFEHSETREGETQGVAFEHESPADFQNS QSPVQDQDKSQLSGREEQSSDAGLFKEEGGLDFLGRQDTDYRSMEYRDVDHRLPGSQMFGYGQSKSFPEGKTARDAQRDLQDQDYRTGPS EEKPSRLIRLSGVPEDATKEEILNAFRTPDGMPVKNLQLKEYNTGYDYGYVCVEFSLLEDAIGCMEANQIRTKWIPLVNGGTTQGPRVPI ILVGNKSDLRSGSSMEAVLPIMSQFPEIETCVECSAKNLRNISELFYYAQKAVLHPTAPLYDPEAKQLRPACAQALTRIFRLSDQDLDQA LSDEELNAFQKSCFGHPLAPQALEDVKTVVCRNVAGGVREDRLTLDGFLFLNTLFIQRGRHETTWTILRRFGYSDALELTADYLSPLIHV PPGCSTELNHLGYQFVQRVFEKHDQDRDGALSPVELQSLFSVFPAAPWGPELPRTVRTEAGRLPLHGYLCQWTLVTYLDVRSCLGHLGYL GYPTLCEQDQAHAITVTREKRLDQEKGQTQRSVLLCKVVGARGVGKSAFLQAFLGRGLGHQDTREQPPGYAIDTVQVNGQEKYLILCEVG TDGLLATSLDATCDVACLMFDGSDPKSFAHCASVYKHHYMDGQTPCLFVSSKADLPEGVAVSGPSPAEFCRKHRLPAPVPFSCAGPAEPS -------------------------------------------------------------- >In-frame_ENST00000443081_ENST00000315082_TCGA-AX-A2H5-01A_RBM6_chr3_50036946_+_RHOT2_chr16_720123_length(transcript)=4229nt_BP=2080nt AGTAAGAGTCTGCGGGACCGGCAGCTGTACTTCATCTCCCAGCGGGCCGAGCGCTGAAGGCAGCGGCGCGGCGCCTTTGTGGTAGCAGTG GCCCCGCGCGGAGGAAGTTCCGGTGTCCGCGGCGCTGGGTCGGTGGCGGAGGCTGAGGAGAAGGAGGAGCGGGCCGTGGAGGCTTCGCCG CCTAGGTACTGCTATAACCAGAATTTGGTAGAAAAAGGATTTACTTGTTGGGGCCCTCTTGATAAAAAGAGATGTGGGGGGATTCTCGAC CTGCTAACAGAACTGGACCTTTTCGGACTGGGTGAAAGCTTTTTCTGCAGCAGTCATGTTGAAAACCTTGTGTTGACTTTCCTCGTGTTC TGAAATGGGAGCATAAAAGTTTACTCCGCCACTTCGTCTTAAAATAGCAAAACTTTGCTGTTTTCTGCAGATCTAGGACCTTGTTACAGA ACTCTGCCAAAAAAAAAATGTTTACAGAAGAATGTGCTGTGATTAGAGAAGAATATGCTGGTGTGTAGATTTCAAACTCTCTGGACAATA TGAATAACACTGTCTTTGTTTCTACAGTGGGAGCCAAGAAGAAAGGTTTGCTCCCGGGTGGAACAGGGATTATCCTCCTCCTCCCCTTAA GAGTCATGCTCAAGAGAGACACTCTGGCAACTTTCCTGGCAGAGATTCACTTCCCTTTGATTTCCAGGGGCATTCGGGGCCTCCTTTTGC AAATGTAGAGGAGCATTCTTTCAGCTATGGAGCTAGAGACGGACCGCATGGTGACTATCGAGGAGGGGAGGGACCTGGACATGATTTCAG GGGGGGAGATTTTTCGTCTTCTGATTTCCAGAGCAGAGATTCATCACAGTTGGACTTCAGGGGTAGGGACATACATTCTGGGGATTTTCG GGATAGAGAAGGACCACCTATGGACTATAGGGGTGGAGATGGTACTTCTATGGATTATAGAGGTAGGGAGGCACCTCATATGAACTACAG AGACAGGGATGCTCACGCTGTTGACTTCAGAGGTAGGGATGCTCCTCCATCTGACTTCAGGGGCCGGGGCACTTATGATTTAGATTTTAG AGGCCGGGATGGATCCCATGCAGATTTTAGGGGAAGGGATTTATCAGATTTGGATTTTAGGGCCAGAGAACAGTCCCGTTCTGATTTTAG GAATAGAGATGTATCTGATTTGGACTTTAGAGACAAAGACGGAACACAAGTAGACTTTAGAGGCCGAGGTTCAGGTACTACTGATCTAGA CTTTAGGGACAGGGATACGCCACATTCAGATTTCAGAGGTAGACACCGATCTAGGACTGATCAGGATTTTAGGGGCAGAGAGATGGGATC TTGTATGGAATTTAAAGATAGGGAGATGCCCCCTGTGGATCCAAATATTTTGGATTACATTCAGCCCTCTACACAAGATAGAGAACATTC TGGTATGAATGTGAACAGGAGAGAAGAATCCACACATGACCATACGATAGAAAGGCCTGCTTTTGGCATTCAGAAGGGAGAATTTGAGCA TTCAGAAACAAGAGAAGGAGAAACACAAGGTGTAGCCTTTGAACATGAGTCTCCAGCAGACTTTCAGAACAGCCAAAGTCCAGTTCAAGA CCAAGATAAGTCACAGCTTTCTGGACGTGAAGAGCAGAGTTCAGATGCTGGTCTGTTTAAAGAAGAAGGCGGTCTGGACTTTCTTGGGCG GCAAGACACCGATTACAGAAGCATGGAGTACCGTGATGTGGATCATAGGCTGCCAGGAAGCCAGATGTTTGGCTATGGCCAGAGCAAGTC TTTTCCAGAGGGCAAAACTGCCCGAGATGCCCAACGGGACCTTCAGGATCAAGATTATAGGACCGGCCCAAGTGAGGAGAAACCCAGCAG GCTTATTCGATTAAGTGGGGTACCTGAAGATGCCACAAAAGAAGAGATTCTTAATGCTTTTCGGACTCCTGATGGCATGCCTGTAAAGAA CTTGCAGTTGAAGGAGTATAACACAGGTTACGACTATGGCTATGTCTGCGTGGAGTTTTCACTCTTGGAAGATGCCATCGGATGCATGGA GGCCAACCAGATTCGAACTAAGTGGATCCCACTGGTGAATGGGGGGACCACGCAGGGGCCCAGGGTGCCCATCATCCTAGTGGGCAACAA GTCAGACCTGCGGTCGGGGAGCTCCATGGAGGCCGTGCTCCCCATCATGAGCCAGTTTCCCGAGATTGAGACCTGCGTGGAGTGTTCGGC CAAGAACCTGAGGAACATCTCAGAGCTGTTCTACTACGCCCAGAAGGCCGTCCTGCATCCCACAGCCCCCCTCTATGACCCTGAGGCCAA GCAGTTGAGGCCCGCGTGCGCCCAGGCGCTGACGCGCATCTTCAGGCTCTCAGATCAGGACCTGGACCAGGCGCTCAGTGACGAAGAGCT CAACGCTTTCCAGAAATCCTGCTTTGGGCACCCCCTGGCCCCGCAGGCCCTGGAGGACGTGAAGACGGTGGTGTGCAGGAACGTGGCGGG CGGCGTGCGGGAGGACCGGCTGACCCTGGATGGTTTCCTCTTCCTGAACACGCTCTTCATCCAGCGCGGCCGGCACGAGACCACCTGGAC CATCCTGCGGCGCTTCGGCTACAGCGATGCCCTGGAGCTGACTGCGGACTATCTCTCCCCTCTGATCCACGTGCCCCCCGGCTGCAGCAC GGAGCTCAACCACCTTGGCTACCAGTTTGTGCAGAGAGTGTTTGAGAAGCACGACCAGGACCGCGACGGCGCCCTCTCGCCCGTGGAGCT GCAAAGCCTTTTCAGTGTGTTCCCAGCAGCGCCCTGGGGCCCCGAGCTCCCACGCACAGTCCGCACAGAGGCCGGCCGGTTGCCCCTGCA CGGATACCTCTGCCAGTGGACCCTGGTGACCTACCTGGACGTCCGGAGCTGCCTTGGACACCTAGGCTACCTGGGCTACCCCACCCTCTG TGAGCAGGACCAGGCCCATGCCATCACAGTCACTCGTGAGAAGAGGCTGGACCAGGAGAAGGGACAGACGCAGCGGAGCGTCCTCCTGTG CAAGGTGGTAGGGGCCCGTGGAGTGGGCAAGTCTGCCTTCCTGCAGGCCTTTCTCGGCCGCGGCCTGGGGCACCAGGACACGAGGGAGCA GCCTCCCGGCTACGCCATCGACACGGTGCAGGTCAATGGACAGGAGAAGTACTTGATCCTCTGTGAGGTGGGCACAGATGGTCTGCTGGC CACATCGCTGGACGCCACCTGTGACGTTGCCTGCTTGATGTTTGATGGCAGTGACCCAAAGTCCTTTGCACATTGTGCCAGCGTCTACAA GCACCATTACATGGACGGGCAGACCCCCTGCCTCTTTGTCTCCTCCAAGGCCGACCTGCCCGAAGGTGTCGCGGTGTCTGGCCCATCACC GGCCGAGTTTTGCCGCAAGCACCGGCTACCCGCTCCCGTGCCGTTCTCCTGTGCTGGCCCAGCCGAGCCCAGCACCACCATCTTCACCCA GCTCGCCACCATGGCCGCCTTCCCACATTTGGTCCACGCAGAGCTGCATCCCTCTTCCTTCTGGCTCCGGGGGCTGCTGGGGGTTGTCGG GGCCGCCGTGGCCGCAGTCCTCAGCTTCTCACTCTACAGGGTCCTGGTGAAGAGCCAGTGAGGCCCCTGGTACCCAAGCCCCCTCCCCTG ACCTGGGTGTGCCTCGCTGCTGGGGCTCTGCAGGGGCAGCACAGCTGGGGTGCAGGCCAGGCTGCCACTCCGGGAACGCCTTTGCGCCGG GACTTTTTGTTTCTGAAGGCAGTCGATCTGCAGCGGGGCCTTATGCTGCCATGCACTGCCCTGGCTCCTGCCGGACCCCCAGGGTGGGCC GTGGCAGGTGGCTGAGCAGGAGCTCCCAAGTGCCGGCCACCGCTGTCAGGGATTGCCCACCCCTGGGCATCATGTGTGTGGGGCCGGGGA GCACAGGTGTGGGAGCTGGTGACCCCAGACCCAGAATTCTCAGGGCTCTACCCCCCTTTCCTGGTCCTAGGTGGCCAGTGGGTATGAGGA GGGCTGGAAGGCAGAGCTTTGGGCCAAAAGCAGGCGTTGGGGGGTCCCCCCTCAAGTTTGGAGCCGTTTCCGTGGTTGTAGCAGAGGACC >In-frame_ENST00000443081_ENST00000315082_TCGA-AX-A2H5-01A_RBM6_chr3_50036946_+_RHOT2_chr16_720123_length(amino acids)=933AA_start in transcript=859_stop in transcript=3660 MDFRGRDIHSGDFRDREGPPMDYRGGDGTSMDYRGREAPHMNYRDRDAHAVDFRGRDAPPSDFRGRGTYDLDFRGRDGSHADFRGRDLSD LDFRAREQSRSDFRNRDVSDLDFRDKDGTQVDFRGRGSGTTDLDFRDRDTPHSDFRGRHRSRTDQDFRGREMGSCMEFKDREMPPVDPNI LDYIQPSTQDREHSGMNVNRREESTHDHTIERPAFGIQKGEFEHSETREGETQGVAFEHESPADFQNSQSPVQDQDKSQLSGREEQSSDA GLFKEEGGLDFLGRQDTDYRSMEYRDVDHRLPGSQMFGYGQSKSFPEGKTARDAQRDLQDQDYRTGPSEEKPSRLIRLSGVPEDATKEEI LNAFRTPDGMPVKNLQLKEYNTGYDYGYVCVEFSLLEDAIGCMEANQIRTKWIPLVNGGTTQGPRVPIILVGNKSDLRSGSSMEAVLPIM SQFPEIETCVECSAKNLRNISELFYYAQKAVLHPTAPLYDPEAKQLRPACAQALTRIFRLSDQDLDQALSDEELNAFQKSCFGHPLAPQA LEDVKTVVCRNVAGGVREDRLTLDGFLFLNTLFIQRGRHETTWTILRRFGYSDALELTADYLSPLIHVPPGCSTELNHLGYQFVQRVFEK HDQDRDGALSPVELQSLFSVFPAAPWGPELPRTVRTEAGRLPLHGYLCQWTLVTYLDVRSCLGHLGYLGYPTLCEQDQAHAITVTREKRL DQEKGQTQRSVLLCKVVGARGVGKSAFLQAFLGRGLGHQDTREQPPGYAIDTVQVNGQEKYLILCEVGTDGLLATSLDATCDVACLMFDG SDPKSFAHCASVYKHHYMDGQTPCLFVSSKADLPEGVAVSGPSPAEFCRKHRLPAPVPFSCAGPAEPSTTIFTQLATMAAFPHLVHAELH -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for RBM6-RHOT2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for RBM6-RHOT2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for RBM6-RHOT2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |