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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RBPJ-RBPJ (FusionGDB2 ID:72618)

Fusion Gene Summary for RBPJ-RBPJ

check button Fusion gene summary
Fusion gene informationFusion gene name: RBPJ-RBPJ
Fusion gene ID: 72618
HgeneTgene
Gene symbol

RBPJ

RBPJ

Gene ID

3516

3516

Gene namerecombination signal binding protein for immunoglobulin kappa J regionrecombination signal binding protein for immunoglobulin kappa J region
SynonymsAOS3|CBF1|IGKJRB|IGKJRB1|KBF2|RBP-J|RBPJK|RBPSUH|SUH|cslAOS3|CBF1|IGKJRB|IGKJRB1|KBF2|RBP-J|RBPJK|RBPSUH|SUH|csl
Cytomap

4p15.2

4p15.2

Type of geneprotein-codingprotein-coding
Descriptionrecombining binding protein suppressor of hairlessCBF-1H-2K binding factor-2RBP-J kappaRBP-JKimmunoglobulin kappa J region recombination signal binding protein 1renal carcinoma antigen NY-REN-30suppressor of hairless homologrecombining binding protein suppressor of hairlessCBF-1H-2K binding factor-2RBP-J kappaRBP-JKimmunoglobulin kappa J region recombination signal binding protein 1renal carcinoma antigen NY-REN-30suppressor of hairless homolog
Modification date2020032920200329
UniProtAcc.

RITA1

Ensembl transtripts involved in fusion geneENST00000345843, ENST00000342295, 
ENST00000361572, ENST00000348160, 
ENST00000355476, ENST00000511401, 
ENST00000507561, ENST00000504907, 
ENST00000342320, 		ENST00000345843, 
ENST00000342295, ENST00000361572, 
ENST00000348160, ENST00000355476, 
ENST00000511401, ENST00000507561, 
ENST00000504907, ENST00000342320, 
Fusion gene scores* DoF score15 X 12 X 6=108013 X 11 X 7=1001
# samples 1613
** MAII scorelog2(16/1080*10)=-2.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/1001*10)=-2.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RBPJ [Title/Abstract] AND RBPJ [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRBPJ(26432443)-RBPJ(26432364), # samples:1
Anticipated loss of major functional domain due to fusion event.RBPJ-RBPJ seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
RBPJ-RBPJ seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RBPJ-RBPJ seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
RBPJ-RBPJ seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRBPJ

GO:0007221

positive regulation of transcription of Notch receptor target

21102556

HgeneRBPJ

GO:0045892

negative regulation of transcription, DNA-templated

10713164

HgeneRBPJ

GO:0061419

positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

23303788

TgeneRBPJ

GO:0007221

positive regulation of transcription of Notch receptor target

21102556

TgeneRBPJ

GO:0045892

negative regulation of transcription, DNA-templated

10713164

TgeneRBPJ

GO:0061419

positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

23303788


check buttonFusion gene breakpoints across RBPJ (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RBPJ (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABM994447RBPJchr4

26432443

-RBPJchr4

26432364

+


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Fusion Gene ORF analysis for RBPJ-RBPJ

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000345843ENST00000345843RBPJchr4

26432443

-RBPJchr4

26432364

+
In-frameENST00000345843ENST00000342295RBPJchr4

26432443

-RBPJchr4

26432364

+
Frame-shiftENST00000345843ENST00000361572RBPJchr4

26432443

-RBPJchr4

26432364

+
Frame-shiftENST00000345843ENST00000348160RBPJchr4

26432443

-RBPJchr4

26432364

+
In-frameENST00000345843ENST00000355476RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000345843ENST00000511401RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000345843ENST00000507561RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000345843ENST00000504907RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000345843ENST00000342320RBPJchr4

26432443

-RBPJchr4

26432364

+
In-frameENST00000342295ENST00000345843RBPJchr4

26432443

-RBPJchr4

26432364

+
Frame-shiftENST00000342295ENST00000342295RBPJchr4

26432443

-RBPJchr4

26432364

+
Frame-shiftENST00000342295ENST00000361572RBPJchr4

26432443

-RBPJchr4

26432364

+
In-frameENST00000342295ENST00000348160RBPJchr4

26432443

-RBPJchr4

26432364

+
Frame-shiftENST00000342295ENST00000355476RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000342295ENST00000511401RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000342295ENST00000507561RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000342295ENST00000504907RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000342295ENST00000342320RBPJchr4

26432443

-RBPJchr4

26432364

+
Frame-shiftENST00000361572ENST00000345843RBPJchr4

26432443

-RBPJchr4

26432364

+
Frame-shiftENST00000361572ENST00000342295RBPJchr4

26432443

-RBPJchr4

26432364

+
In-frameENST00000361572ENST00000361572RBPJchr4

26432443

-RBPJchr4

26432364

+
Frame-shiftENST00000361572ENST00000348160RBPJchr4

26432443

-RBPJchr4

26432364

+
Frame-shiftENST00000361572ENST00000355476RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000361572ENST00000511401RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000361572ENST00000507561RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000361572ENST00000504907RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000361572ENST00000342320RBPJchr4

26432443

-RBPJchr4

26432364

+
Frame-shiftENST00000348160ENST00000345843RBPJchr4

26432443

-RBPJchr4

26432364

+
In-frameENST00000348160ENST00000342295RBPJchr4

26432443

-RBPJchr4

26432364

+
Frame-shiftENST00000348160ENST00000361572RBPJchr4

26432443

-RBPJchr4

26432364

+
Frame-shiftENST00000348160ENST00000348160RBPJchr4

26432443

-RBPJchr4

26432364

+
In-frameENST00000348160ENST00000355476RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000348160ENST00000511401RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000348160ENST00000507561RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000348160ENST00000504907RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000348160ENST00000342320RBPJchr4

26432443

-RBPJchr4

26432364

+
In-frameENST00000355476ENST00000345843RBPJchr4

26432443

-RBPJchr4

26432364

+
Frame-shiftENST00000355476ENST00000342295RBPJchr4

26432443

-RBPJchr4

26432364

+
Frame-shiftENST00000355476ENST00000361572RBPJchr4

26432443

-RBPJchr4

26432364

+
In-frameENST00000355476ENST00000348160RBPJchr4

26432443

-RBPJchr4

26432364

+
Frame-shiftENST00000355476ENST00000355476RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000355476ENST00000511401RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000355476ENST00000507561RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000355476ENST00000504907RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000355476ENST00000342320RBPJchr4

26432443

-RBPJchr4

26432364

+
intron-3CDSENST00000511401ENST00000345843RBPJchr4

26432443

-RBPJchr4

26432364

+
intron-3CDSENST00000511401ENST00000342295RBPJchr4

26432443

-RBPJchr4

26432364

+
intron-3CDSENST00000511401ENST00000361572RBPJchr4

26432443

-RBPJchr4

26432364

+
intron-3CDSENST00000511401ENST00000348160RBPJchr4

26432443

-RBPJchr4

26432364

+
intron-3CDSENST00000511401ENST00000355476RBPJchr4

26432443

-RBPJchr4

26432364

+
intron-intronENST00000511401ENST00000511401RBPJchr4

26432443

-RBPJchr4

26432364

+
intron-intronENST00000511401ENST00000507561RBPJchr4

26432443

-RBPJchr4

26432364

+
intron-intronENST00000511401ENST00000504907RBPJchr4

26432443

-RBPJchr4

26432364

+
intron-intronENST00000511401ENST00000342320RBPJchr4

26432443

-RBPJchr4

26432364

+
Frame-shiftENST00000507561ENST00000345843RBPJchr4

26432443

-RBPJchr4

26432364

+
In-frameENST00000507561ENST00000342295RBPJchr4

26432443

-RBPJchr4

26432364

+
Frame-shiftENST00000507561ENST00000361572RBPJchr4

26432443

-RBPJchr4

26432364

+
Frame-shiftENST00000507561ENST00000348160RBPJchr4

26432443

-RBPJchr4

26432364

+
In-frameENST00000507561ENST00000355476RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000507561ENST00000511401RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000507561ENST00000507561RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000507561ENST00000504907RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000507561ENST00000342320RBPJchr4

26432443

-RBPJchr4

26432364

+
3UTR-3CDSENST00000504907ENST00000345843RBPJchr4

26432443

-RBPJchr4

26432364

+
3UTR-3CDSENST00000504907ENST00000342295RBPJchr4

26432443

-RBPJchr4

26432364

+
3UTR-3CDSENST00000504907ENST00000361572RBPJchr4

26432443

-RBPJchr4

26432364

+
3UTR-3CDSENST00000504907ENST00000348160RBPJchr4

26432443

-RBPJchr4

26432364

+
3UTR-3CDSENST00000504907ENST00000355476RBPJchr4

26432443

-RBPJchr4

26432364

+
3UTR-intronENST00000504907ENST00000511401RBPJchr4

26432443

-RBPJchr4

26432364

+
3UTR-intronENST00000504907ENST00000507561RBPJchr4

26432443

-RBPJchr4

26432364

+
3UTR-intronENST00000504907ENST00000504907RBPJchr4

26432443

-RBPJchr4

26432364

+
3UTR-intronENST00000504907ENST00000342320RBPJchr4

26432443

-RBPJchr4

26432364

+
Frame-shiftENST00000342320ENST00000345843RBPJchr4

26432443

-RBPJchr4

26432364

+
Frame-shiftENST00000342320ENST00000342295RBPJchr4

26432443

-RBPJchr4

26432364

+
In-frameENST00000342320ENST00000361572RBPJchr4

26432443

-RBPJchr4

26432364

+
Frame-shiftENST00000342320ENST00000348160RBPJchr4

26432443

-RBPJchr4

26432364

+
Frame-shiftENST00000342320ENST00000355476RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000342320ENST00000511401RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000342320ENST00000507561RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000342320ENST00000504907RBPJchr4

26432443

-RBPJchr4

26432364

+
5CDS-intronENST00000342320ENST00000342320RBPJchr4

26432443

-RBPJchr4

26432364

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for RBPJ-RBPJ


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RBPJ-RBPJ


check button Go to

FGviewer for the breakpoints of chr4:26432443-chr4:26432364

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.RBPJ

RITA1

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.269

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRBPJchr4:26432443chr4:26432364ENST00000342295012355_4450501.0DomainNote=IPT/TIG
TgeneRBPJchr4:26432443chr4:26432364ENST00000342320011355_4450487.0DomainNote=IPT/TIG
TgeneRBPJchr4:26432443chr4:26432364ENST00000345843011355_4450486.0DomainNote=IPT/TIG
TgeneRBPJchr4:26432443chr4:26432364ENST00000348160011355_4450488.0DomainNote=IPT/TIG
TgeneRBPJchr4:26432443chr4:26432364ENST00000355476012355_4450487.0DomainNote=IPT/TIG
TgeneRBPJchr4:26432443chr4:26432364ENST00000361572011355_4450501.0DomainNote=IPT/TIG
TgeneRBPJchr4:26432443chr4:26432364ENST00000507561011355_4450466.0DomainNote=IPT/TIG
TgeneRBPJchr4:26432443chr4:26432364ENST00000342295012165_1700501.0RegionDNA binding
TgeneRBPJchr4:26432443chr4:26432364ENST00000342295012192_1970501.0RegionDNA binding
TgeneRBPJchr4:26432443chr4:26432364ENST0000034229501257_670501.0RegionDNA binding
TgeneRBPJchr4:26432443chr4:26432364ENST00000342320011165_1700487.0RegionDNA binding
TgeneRBPJchr4:26432443chr4:26432364ENST00000342320011192_1970487.0RegionDNA binding
TgeneRBPJchr4:26432443chr4:26432364ENST0000034232001157_670487.0RegionDNA binding
TgeneRBPJchr4:26432443chr4:26432364ENST00000345843011165_1700486.0RegionDNA binding
TgeneRBPJchr4:26432443chr4:26432364ENST00000345843011192_1970486.0RegionDNA binding
TgeneRBPJchr4:26432443chr4:26432364ENST0000034584301157_670486.0RegionDNA binding
TgeneRBPJchr4:26432443chr4:26432364ENST00000348160011165_1700488.0RegionDNA binding
TgeneRBPJchr4:26432443chr4:26432364ENST00000348160011192_1970488.0RegionDNA binding
TgeneRBPJchr4:26432443chr4:26432364ENST0000034816001157_670488.0RegionDNA binding
TgeneRBPJchr4:26432443chr4:26432364ENST00000355476012165_1700487.0RegionDNA binding
TgeneRBPJchr4:26432443chr4:26432364ENST00000355476012192_1970487.0RegionDNA binding
TgeneRBPJchr4:26432443chr4:26432364ENST0000035547601257_670487.0RegionDNA binding
TgeneRBPJchr4:26432443chr4:26432364ENST00000361572011165_1700501.0RegionDNA binding
TgeneRBPJchr4:26432443chr4:26432364ENST00000361572011192_1970501.0RegionDNA binding
TgeneRBPJchr4:26432443chr4:26432364ENST0000036157201157_670501.0RegionDNA binding
TgeneRBPJchr4:26432443chr4:26432364ENST00000507561011165_1700466.0RegionDNA binding
TgeneRBPJchr4:26432443chr4:26432364ENST00000507561011192_1970466.0RegionDNA binding
TgeneRBPJchr4:26432443chr4:26432364ENST0000050756101157_670466.0RegionDNA binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRBPJchr4:26432443chr4:26432364ENST00000342295-112355_4450501.0DomainNote=IPT/TIG
HgeneRBPJchr4:26432443chr4:26432364ENST00000342320-111355_4450487.0DomainNote=IPT/TIG
HgeneRBPJchr4:26432443chr4:26432364ENST00000345843-111355_4450486.0DomainNote=IPT/TIG
HgeneRBPJchr4:26432443chr4:26432364ENST00000348160-111355_4450488.0DomainNote=IPT/TIG
HgeneRBPJchr4:26432443chr4:26432364ENST00000355476-112355_4450487.0DomainNote=IPT/TIG
HgeneRBPJchr4:26432443chr4:26432364ENST00000361572-111355_4450501.0DomainNote=IPT/TIG
HgeneRBPJchr4:26432443chr4:26432364ENST00000507561-111355_4450466.0DomainNote=IPT/TIG
HgeneRBPJchr4:26432443chr4:26432364ENST00000342295-112165_1700501.0RegionDNA binding
HgeneRBPJchr4:26432443chr4:26432364ENST00000342295-112192_1970501.0RegionDNA binding
HgeneRBPJchr4:26432443chr4:26432364ENST00000342295-11257_670501.0RegionDNA binding
HgeneRBPJchr4:26432443chr4:26432364ENST00000342320-111165_1700487.0RegionDNA binding
HgeneRBPJchr4:26432443chr4:26432364ENST00000342320-111192_1970487.0RegionDNA binding
HgeneRBPJchr4:26432443chr4:26432364ENST00000342320-11157_670487.0RegionDNA binding
HgeneRBPJchr4:26432443chr4:26432364ENST00000345843-111165_1700486.0RegionDNA binding
HgeneRBPJchr4:26432443chr4:26432364ENST00000345843-111192_1970486.0RegionDNA binding
HgeneRBPJchr4:26432443chr4:26432364ENST00000345843-11157_670486.0RegionDNA binding
HgeneRBPJchr4:26432443chr4:26432364ENST00000348160-111165_1700488.0RegionDNA binding
HgeneRBPJchr4:26432443chr4:26432364ENST00000348160-111192_1970488.0RegionDNA binding
HgeneRBPJchr4:26432443chr4:26432364ENST00000348160-11157_670488.0RegionDNA binding
HgeneRBPJchr4:26432443chr4:26432364ENST00000355476-112165_1700487.0RegionDNA binding
HgeneRBPJchr4:26432443chr4:26432364ENST00000355476-112192_1970487.0RegionDNA binding
HgeneRBPJchr4:26432443chr4:26432364ENST00000355476-11257_670487.0RegionDNA binding
HgeneRBPJchr4:26432443chr4:26432364ENST00000361572-111165_1700501.0RegionDNA binding
HgeneRBPJchr4:26432443chr4:26432364ENST00000361572-111192_1970501.0RegionDNA binding
HgeneRBPJchr4:26432443chr4:26432364ENST00000361572-11157_670501.0RegionDNA binding
HgeneRBPJchr4:26432443chr4:26432364ENST00000507561-111165_1700466.0RegionDNA binding
HgeneRBPJchr4:26432443chr4:26432364ENST00000507561-111192_1970466.0RegionDNA binding
HgeneRBPJchr4:26432443chr4:26432364ENST00000507561-11157_670466.0RegionDNA binding


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Fusion Gene Sequence for RBPJ-RBPJ


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for RBPJ-RBPJ


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RBPJ-RBPJ


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RBPJ-RBPJ


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRBPJC3553748ADAMS-OLIVER SYNDROME 33GENOMICS_ENGLAND;UNIPROT
HgeneRBPJC0003873Rheumatoid Arthritis2CTD_human
HgeneRBPJC4551482Adams-Oliver syndrome 12CTD_human;GENOMICS_ENGLAND
HgeneRBPJC0014175Endometriosis1CTD_human
HgeneRBPJC0026769Multiple Sclerosis1CTD_human
HgeneRBPJC0265268Adams Oliver syndrome1ORPHANET
HgeneRBPJC0269102Endometrioma1CTD_human
HgeneRBPJC0751324Multiple Sclerosis, Acute Fulminating1CTD_human
TgeneRBPJC3553748ADAMS-OLIVER SYNDROME 33GENOMICS_ENGLAND;UNIPROT
TgeneRBPJC0003873Rheumatoid Arthritis2CTD_human
TgeneRBPJC4551482Adams-Oliver syndrome 12CTD_human;GENOMICS_ENGLAND
TgeneRBPJC0014175Endometriosis1CTD_human
TgeneRBPJC0026769Multiple Sclerosis1CTD_human
TgeneRBPJC0265268Adams Oliver syndrome1ORPHANET
TgeneRBPJC0269102Endometrioma1CTD_human
TgeneRBPJC0751324Multiple Sclerosis, Acute Fulminating1CTD_human