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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RCAN1-RUNX1 (FusionGDB2 ID:72666)

Fusion Gene Summary for RCAN1-RUNX1

check button Fusion gene summary
Fusion gene informationFusion gene name: RCAN1-RUNX1
Fusion gene ID: 72666
HgeneTgene
Gene symbol

RCAN1

RUNX1

Gene ID

1827

861

Gene nameregulator of calcineurin 1RUNX family transcription factor 1
SynonymsADAPT78|CSP1|DSC1|DSCR1|MCIP1|RCN1AML1|AML1-EVI-1|AMLCR1|CBF2alpha|CBFA2|EVI-1|PEBP2aB|PEBP2alpha
Cytomap

21q22.12

21q22.12

Type of geneprotein-codingprotein-coding
Descriptioncalcipressin-1Down syndrome candidate region 1Down syndrome critical region gene 1calcium and oxidant-inducible mRNAmodulatory calcineurin-interacting protein 1myocyte-enriched calcineurin-interacting protein 1near DSCR proline-rich proteinrunt-related transcription factor 1AML1-EVI-1 fusion proteinPEA2-alpha BPEBP2-alpha BSL3-3 enhancer factor 1 alpha B subunitSL3/AKV core-binding factor alpha B subunitacute myeloid leukemia 1 proteincore-binding factor, runt domain, alpha subunit 2
Modification date2020032020200322
UniProtAcc.

Q06455

Ensembl transtripts involved in fusion geneENST00000487990, ENST00000399272, 
ENST00000489903, ENST00000313806, 
ENST00000443408, ENST00000482533, 
ENST00000481448, ENST00000381132, 
ENST00000381135, ENST00000492600, 
ENST00000344691, ENST00000325074, 
ENST00000437180, ENST00000300305, 
ENST00000399240, ENST00000486278, 
ENST00000494829, ENST00000358356, 
Fusion gene scores* DoF score5 X 6 X 5=15036 X 59 X 13=27612
# samples 963
** MAII scorelog2(9/150*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(63/27612*10)=-5.45379975055797
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RCAN1 [Title/Abstract] AND RUNX1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRCAN1(35987059)-RUNX1(36171759), # samples:3
RUNX1(36231771)-RCAN1(35896008), # samples:2
Anticipated loss of major functional domain due to fusion event.RCAN1-RUNX1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
RCAN1-RUNX1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
RCAN1-RUNX1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRUNX1

GO:0030097

hemopoiesis

21873977

TgeneRUNX1

GO:0045893

positive regulation of transcription, DNA-templated

10207087|14970218

TgeneRUNX1

GO:0045944

positive regulation of transcription by RNA polymerase II

9199349|10207087|14970218|21873977


check buttonFusion gene breakpoints across RCAN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RUNX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A256RCAN1chr21

35987058

-RUNX1chr21

36171759

-
ChimerDB4BRCATCGA-AR-A256-01ARCAN1chr21

35987059

-RUNX1chr21

36171759

-
ChimerDB4BRCATCGA-A7-A6VV-01ARCAN1chr21

35987059

-RUNX1chr21

36171759

-
ChimerDB4UCSTCGA-N5-A4RTRCAN1chr21

35987059

-RUNX1chr21

36253010

-
ChimerDB4BRCATCGA-A7-A6VV-01ARCAN1chr21

35987059

-RUNX1chr21

36171759

-
ChimerDB4UCSTCGA-N5-A4RT-01ARCAN1chr21

35987059

-RUNX1chr21

36253010

-


Top

Fusion Gene ORF analysis for RCAN1-RUNX1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000487990ENST00000344691RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000487990ENST00000325074RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000487990ENST00000437180RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000487990ENST00000300305RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000487990ENST00000399240RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000487990ENST00000486278RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000487990ENST00000494829RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000487990ENST00000358356RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000399272ENST00000344691RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000399272ENST00000325074RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000399272ENST00000437180RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000399272ENST00000300305RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000399272ENST00000399240RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000399272ENST00000486278RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000399272ENST00000494829RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000399272ENST00000358356RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000489903ENST00000344691RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000489903ENST00000325074RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000489903ENST00000437180RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000489903ENST00000300305RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000489903ENST00000399240RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000489903ENST00000486278RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000489903ENST00000494829RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000489903ENST00000358356RCAN1chr21

35987058

-RUNX1chr21

36171759

-
Frame-shiftENST00000313806ENST00000344691RCAN1chr21

35987058

-RUNX1chr21

36171759

-
Frame-shiftENST00000313806ENST00000325074RCAN1chr21

35987058

-RUNX1chr21

36171759

-
Frame-shiftENST00000313806ENST00000437180RCAN1chr21

35987058

-RUNX1chr21

36171759

-
Frame-shiftENST00000313806ENST00000300305RCAN1chr21

35987058

-RUNX1chr21

36171759

-
Frame-shiftENST00000313806ENST00000399240RCAN1chr21

35987058

-RUNX1chr21

36171759

-
5CDS-intronENST00000313806ENST00000486278RCAN1chr21

35987058

-RUNX1chr21

36171759

-
5CDS-intronENST00000313806ENST00000494829RCAN1chr21

35987058

-RUNX1chr21

36171759

-
5CDS-intronENST00000313806ENST00000358356RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000443408ENST00000344691RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000443408ENST00000325074RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000443408ENST00000437180RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000443408ENST00000300305RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000443408ENST00000399240RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000443408ENST00000486278RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000443408ENST00000494829RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000443408ENST00000358356RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000482533ENST00000344691RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000482533ENST00000325074RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000482533ENST00000437180RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000482533ENST00000300305RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000482533ENST00000399240RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000482533ENST00000486278RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000482533ENST00000494829RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000482533ENST00000358356RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000481448ENST00000344691RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000481448ENST00000325074RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000481448ENST00000437180RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000481448ENST00000300305RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000481448ENST00000399240RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000481448ENST00000486278RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000481448ENST00000494829RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000481448ENST00000358356RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000381132ENST00000344691RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000381132ENST00000325074RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000381132ENST00000437180RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000381132ENST00000300305RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000381132ENST00000399240RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000381132ENST00000486278RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000381132ENST00000494829RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000381132ENST00000358356RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000381135ENST00000344691RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000381135ENST00000325074RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000381135ENST00000437180RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000381135ENST00000300305RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000381135ENST00000399240RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000381135ENST00000486278RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000381135ENST00000494829RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000381135ENST00000358356RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000492600ENST00000344691RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000492600ENST00000325074RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000492600ENST00000437180RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000492600ENST00000300305RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000492600ENST00000399240RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000492600ENST00000486278RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000492600ENST00000494829RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-intronENST00000492600ENST00000358356RCAN1chr21

35987058

-RUNX1chr21

36171759

-
intron-3CDSENST00000487990ENST00000344691RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000487990ENST00000325074RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000487990ENST00000437180RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000487990ENST00000300305RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000487990ENST00000399240RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000487990ENST00000486278RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000487990ENST00000494829RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000487990ENST00000358356RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000399272ENST00000344691RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000399272ENST00000325074RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000399272ENST00000437180RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000399272ENST00000300305RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000399272ENST00000399240RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000399272ENST00000486278RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000399272ENST00000494829RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000399272ENST00000358356RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000489903ENST00000344691RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000489903ENST00000325074RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000489903ENST00000437180RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000489903ENST00000300305RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000489903ENST00000399240RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000489903ENST00000486278RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000489903ENST00000494829RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000489903ENST00000358356RCAN1chr21

35987059

-RUNX1chr21

36171759

-
Frame-shiftENST00000313806ENST00000344691RCAN1chr21

35987059

-RUNX1chr21

36171759

-
Frame-shiftENST00000313806ENST00000325074RCAN1chr21

35987059

-RUNX1chr21

36171759

-
Frame-shiftENST00000313806ENST00000437180RCAN1chr21

35987059

-RUNX1chr21

36171759

-
Frame-shiftENST00000313806ENST00000300305RCAN1chr21

35987059

-RUNX1chr21

36171759

-
Frame-shiftENST00000313806ENST00000399240RCAN1chr21

35987059

-RUNX1chr21

36171759

-
5CDS-intronENST00000313806ENST00000486278RCAN1chr21

35987059

-RUNX1chr21

36171759

-
5CDS-intronENST00000313806ENST00000494829RCAN1chr21

35987059

-RUNX1chr21

36171759

-
5CDS-intronENST00000313806ENST00000358356RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000443408ENST00000344691RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000443408ENST00000325074RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000443408ENST00000437180RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000443408ENST00000300305RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000443408ENST00000399240RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000443408ENST00000486278RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000443408ENST00000494829RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000443408ENST00000358356RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000482533ENST00000344691RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000482533ENST00000325074RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000482533ENST00000437180RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000482533ENST00000300305RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000482533ENST00000399240RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000482533ENST00000486278RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000482533ENST00000494829RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000482533ENST00000358356RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000481448ENST00000344691RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000481448ENST00000325074RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000481448ENST00000437180RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000481448ENST00000300305RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000481448ENST00000399240RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000481448ENST00000486278RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000481448ENST00000494829RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000481448ENST00000358356RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000381132ENST00000344691RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000381132ENST00000325074RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000381132ENST00000437180RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000381132ENST00000300305RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000381132ENST00000399240RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000381132ENST00000486278RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000381132ENST00000494829RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000381132ENST00000358356RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000381135ENST00000344691RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000381135ENST00000325074RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000381135ENST00000437180RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000381135ENST00000300305RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000381135ENST00000399240RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000381135ENST00000486278RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000381135ENST00000494829RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000381135ENST00000358356RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000492600ENST00000344691RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000492600ENST00000325074RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000492600ENST00000437180RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000492600ENST00000300305RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000492600ENST00000399240RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000492600ENST00000486278RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000492600ENST00000494829RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-intronENST00000492600ENST00000358356RCAN1chr21

35987059

-RUNX1chr21

36171759

-
intron-3CDSENST00000487990ENST00000344691RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000487990ENST00000325074RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000487990ENST00000437180RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000487990ENST00000300305RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000487990ENST00000399240RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000487990ENST00000486278RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-intronENST00000487990ENST00000494829RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-intronENST00000487990ENST00000358356RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000399272ENST00000344691RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000399272ENST00000325074RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000399272ENST00000437180RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000399272ENST00000300305RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000399272ENST00000399240RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000399272ENST00000486278RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-intronENST00000399272ENST00000494829RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-intronENST00000399272ENST00000358356RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000489903ENST00000344691RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000489903ENST00000325074RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000489903ENST00000437180RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000489903ENST00000300305RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000489903ENST00000399240RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000489903ENST00000486278RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-intronENST00000489903ENST00000494829RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-intronENST00000489903ENST00000358356RCAN1chr21

35987059

-RUNX1chr21

36253010

-
In-frameENST00000313806ENST00000344691RCAN1chr21

35987059

-RUNX1chr21

36253010

-
In-frameENST00000313806ENST00000325074RCAN1chr21

35987059

-RUNX1chr21

36253010

-
In-frameENST00000313806ENST00000437180RCAN1chr21

35987059

-RUNX1chr21

36253010

-
In-frameENST00000313806ENST00000300305RCAN1chr21

35987059

-RUNX1chr21

36253010

-
In-frameENST00000313806ENST00000399240RCAN1chr21

35987059

-RUNX1chr21

36253010

-
In-frameENST00000313806ENST00000486278RCAN1chr21

35987059

-RUNX1chr21

36253010

-
5CDS-intronENST00000313806ENST00000494829RCAN1chr21

35987059

-RUNX1chr21

36253010

-
5CDS-intronENST00000313806ENST00000358356RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000443408ENST00000344691RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000443408ENST00000325074RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000443408ENST00000437180RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000443408ENST00000300305RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000443408ENST00000399240RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000443408ENST00000486278RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-intronENST00000443408ENST00000494829RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-intronENST00000443408ENST00000358356RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000482533ENST00000344691RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000482533ENST00000325074RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000482533ENST00000437180RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000482533ENST00000300305RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000482533ENST00000399240RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000482533ENST00000486278RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-intronENST00000482533ENST00000494829RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-intronENST00000482533ENST00000358356RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000481448ENST00000344691RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000481448ENST00000325074RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000481448ENST00000437180RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000481448ENST00000300305RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000481448ENST00000399240RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000481448ENST00000486278RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-intronENST00000481448ENST00000494829RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-intronENST00000481448ENST00000358356RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000381132ENST00000344691RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000381132ENST00000325074RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000381132ENST00000437180RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000381132ENST00000300305RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000381132ENST00000399240RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000381132ENST00000486278RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-intronENST00000381132ENST00000494829RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-intronENST00000381132ENST00000358356RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000381135ENST00000344691RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000381135ENST00000325074RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000381135ENST00000437180RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000381135ENST00000300305RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000381135ENST00000399240RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000381135ENST00000486278RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-intronENST00000381135ENST00000494829RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-intronENST00000381135ENST00000358356RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000492600ENST00000344691RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000492600ENST00000325074RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000492600ENST00000437180RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000492600ENST00000300305RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000492600ENST00000399240RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-3CDSENST00000492600ENST00000486278RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-intronENST00000492600ENST00000494829RCAN1chr21

35987059

-RUNX1chr21

36253010

-
intron-intronENST00000492600ENST00000358356RCAN1chr21

35987059

-RUNX1chr21

36253010

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000313806RCAN1chr2135987059-ENST00000344691RUNX1chr2136253010-580938321474490
ENST00000313806RCAN1chr2135987059-ENST00000325074RUNX1chr2136253010-580938321474490
ENST00000313806RCAN1chr2135987059-ENST00000437180RUNX1chr2136253010-580938321474490
ENST00000313806RCAN1chr2135987059-ENST00000300305RUNX1chr2136253010-580938321474490
ENST00000313806RCAN1chr2135987059-ENST00000399240RUNX1chr2136253010-163238321282426
ENST00000313806RCAN1chr2135987059-ENST00000486278RUNX1chr2136253010-6803832679226

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000313806ENST00000344691RCAN1chr2135987059-RUNX1chr2136253010-0.0009847910.9990152
ENST00000313806ENST00000325074RCAN1chr2135987059-RUNX1chr2136253010-0.0009847910.9990152
ENST00000313806ENST00000437180RCAN1chr2135987059-RUNX1chr2136253010-0.0009847910.9990152
ENST00000313806ENST00000300305RCAN1chr2135987059-RUNX1chr2136253010-0.0009847910.9990152
ENST00000313806ENST00000399240RCAN1chr2135987059-RUNX1chr2136253010-0.018631180.9813688
ENST00000313806ENST00000486278RCAN1chr2135987059-RUNX1chr2136253010-0.0093213620.9906786

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Fusion Genomic Features for RCAN1-RUNX1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RCAN1-RUNX1


check button Go to

FGviewer for the breakpoints of chr21:35987059-chr21:36253010

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.RUNX1

Q06455

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199, PubMed:10688654). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588). {ECO:0000250|UniProtKB:Q61909, ECO:0000269|PubMed:10688654, ECO:0000269|PubMed:10973986, ECO:0000269|PubMed:16803958, ECO:0000269|PubMed:23251453, ECO:0000269|PubMed:23812588, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRUNX1chr21:35987059chr21:36253010ENST0000030030528187_453117.0481.0Compositional biasNote=Pro/Ser/Thr-rich
TgeneRUNX1chr21:35987059chr21:36253010ENST0000032507417187_453105.0469.0Compositional biasNote=Pro/Ser/Thr-rich
TgeneRUNX1chr21:35987059chr21:36253010ENST0000034469106187_45390.0454.0Compositional biasNote=Pro/Ser/Thr-rich
TgeneRUNX1chr21:35987059chr21:36253010ENST0000035835605187_45390.0251.0Compositional biasNote=Pro/Ser/Thr-rich
TgeneRUNX1chr21:35987059chr21:36253010ENST0000043718039187_453117.0481.0Compositional biasNote=Pro/Ser/Thr-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRCAN1chr21:35987059chr21:36253010ENST00000313806-14221_22984.0253.0Compositional biasNote=Poly-Glu
HgeneRCAN1chr21:35987059chr21:36253010ENST00000381132-14221_2290198.0Compositional biasNote=Poly-Glu
HgeneRCAN1chr21:35987059chr21:36253010ENST00000399272-14221_2290172.0Compositional biasNote=Poly-Glu
HgeneRCAN1chr21:35987059chr21:36253010ENST00000443408-14221_2290118.0Compositional biasNote=Poly-Glu
HgeneRCAN1chr21:35987059chr21:36253010ENST00000482533-13221_2290118.0Compositional biasNote=Poly-Glu
HgeneRCAN1chr21:35987059chr21:36253010ENST00000487990-14221_2290118.0Compositional biasNote=Poly-Glu
TgeneRUNX1chr21:35987059chr21:36253010ENST000003003052850_178117.0481.0DomainRunt
TgeneRUNX1chr21:35987059chr21:36253010ENST000003250741750_178105.0469.0DomainRunt
TgeneRUNX1chr21:35987059chr21:36253010ENST000003446910650_17890.0454.0DomainRunt
TgeneRUNX1chr21:35987059chr21:36253010ENST000003583560550_17890.0251.0DomainRunt
TgeneRUNX1chr21:35987059chr21:36253010ENST000004371803950_178117.0481.0DomainRunt


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Fusion Gene Sequence for RCAN1-RUNX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000313806_ENST00000344691_TCGA-N5-A4RT_RCAN1_chr21_35987059_-_RUNX1_chr21_36253010_length(transcript)=5809nt_BP=383nt
GCCTGCCGCCGCGCGATTCCGAGGGGGTTAACGGCGGAGCCGCCGGCCGGGCGCGGACCGGAGCGCGTGAGGCTCCGGCGCGCAAGCCCG
GAGCAGCCCGCTGGGGCGCACAGGGTCGCGCGGGCGCGGGGATGGAGGACGGCGTGGCCGGTCCCCAGCTCGGGGCCGCGGCGGAGGCGG
CGGAGGCGGCCGAGGCGCGAGCGCGGCCCGGGGTGACGCTGCGGCCCTTCGCGCCCCTCTCGGGGGCGGCCGAGGCGGACGAGGGCGGCG
GCGACTGGAGCTTCATTGACTGCGAGATGGAGGAGGTGGACCTGCAGGACCTGCCCAGCGCCACCATCGCCTGTCACCTGGACCCGCGCG
TGTTCGTGGACGGCCTGTGCCGGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACTGTGATGGCTGGCAATGATGAAAACT
ACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTCAGGTTTGTCGGTCGAAGTGGAAGAG
GGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGAGCCATCAAAATCACAGTGGATGGGC
CCCGAGAACCTCGAAGACATCGGCAGAAACTAGATGATCAGACCAAGCCCGGGAGCTTGTCCTTTTCCGAGCGGCTCAGTGAACTGGAGC
AGCTGCGGCGCACAGCCATGAGGGTCAGCCCACACCACCCAGCCCCCACGCCCAACCCTCGTGCCTCCCTGAACCACTCCACTGCCTTTA
ACCCTCAGCCTCAGAGTCAGATGCAGGATACAAGGCAGATCCAACCATCCCCACCGTGGTCCTACGATCAGTCCTACCAATACCTGGGAT
CCATTGCCTCTCCTTCTGTGCACCCAGCAACGCCCATTTCACCTGGACGTGCCAGCGGCATGACAACCCTCTCTGCAGAACTTTCCAGTC
GACTCTCAACGGCACCCGACCTGACAGCGTTCAGCGACCCGCGCCAGTTCCCCGCGCTGCCCTCCATCTCCGACCCCCGCATGCACTATC
CAGGCGCCTTCACCTACTCCCCGACGCCGGTCACCTCGGGCATCGGCATCGGCATGTCGGCCATGGGCTCGGCCACGCGCTACCACACCT
ACCTGCCGCCGCCCTACCCCGGCTCGTCGCAAGCGCAGGGAGGCCCGTTCCAAGCCAGCTCGCCCTCCTACCACCTGTACTACGGCGCCT
CGGCCGGCTCCTACCAGTTCTCCATGGTGGGCGGCGAGCGCTCGCCGCCGCGCATCCTGCCGCCCTGCACCAACGCCTCCACCGGCTCCG
CGCTGCTCAACCCCAGCCTCCCGAACCAGAGCGACGTGGTGGAGGCCGAGGGCAGCCACAGCAACTCCCCCACCAACATGGCGCCCTCCG
CGCGCCTGGAGGAGGCCGTGTGGAGGCCCTACTGAGGCGCCAGGCCTGGCCCGGCTGGGCCCCGCGGGCCGCCGCCTTCGCCTCCGGGCG
CGCGGGCCTCCTGTTCGCGACAAGCCCGCCGGGATCCCGGGCCCTGGGCCCGGCCACCGTCCTGGGGCCGAGGGCGCCCGACGGCCAGGA
TCTCGCTGTAGGTCAGGCCCGCGCAGCCTCCTGCGCCCAGAAGCCCACGCCGCCGCCGTCTGCTGGCGCCCCGGCCCTCGCGGAGGTGTC
CGAGGCGACGCACCTCGAGGGTGTCCGCCGGCCCCAGCACCCAGGGGACGCGCTGGAAAGCAAACAGGAAGATTCCCGGAGGGAAACTGT
GAATGCTTCTGATTTAGCAATGCTGTGAATAAAAAGAAAGATTTTATACCCTTGACTTAACTTTTTAACCAAGTTGTTTATTCCAAAGAG
TGTGGAATTTTGGTTGGGGTGGGGGGAGAGGAGGGATGCAACTCGCCCTGTTTGGCATCTAATTCTTATTTTTAATTTTTCCGCACCTTA
TCAATTGCAAAATGCGTATTTGCATTTGGGTGGTTTTTATTTTTATATACGTTTATATAAATATATATAAATTGAGCTTGCTTCTTTCTT
GCTTTGACCATGGAAAGAAATATGATTCCCTTTTCTTTAAGTTTTATTTAACTTTTCTTTTGGACTTTTGGGTAGTTGTTTTTTTTTGTT
TTGTTTTGTTTTTTTGAGAAACAGCTACAGCTTTGGGTCATTTTTAACTACTGTATTCCCACAAGGAATCCCCAGATATTTATGTATCTT
GATGTTCAGACATTTATGTGTTGATAATTTTTTAATTATTTAAATGTACTTATATTAAGAAAAATATCAAGTACTACATTTTCTTTTGTT
CTTGATAGTAGCCAAAGTTAAATGTATCACATTGAAGAAGGCTAGAAAAAAAGAATGAGTAATGTGATCGCTTGGTTATCCAGAAGTATT
GTTTACATTAAACTCCCTTTCATGTTAATCAAACAAGTGAGTAGCTCACGCAGCAACGTTTTTAATAGGATTTTTAGACACTGAGGGTCA
CTCCAAGGATCAGAAGTATGGAATTTTCTGCCAGGCTCAACAAGGGTCTCATATCTAACTTCCTCCTTAAAACAGAGAAGGTCAATCTAG
TTCCAGAGGGTTGAGGCAGGTGCCAATAATTACATCTTTGGAGAGGATTTGATTTCTGCCCAGGGATTTGCTCACCCCAAGGTCATCTGA
TAATTTCACAGATGCTGTGTAACAGAACACAGCCAAAGTAAACTGTGTAGGGGAGCCACATTTACATAGGAACCAAATCAATGAATTTAG
GGGTTACGATTATAGCAATTTAAGGGCCCACCAGAAGCAGGCCTCGAGGAGTCAATTTGCCTCTGTGTGCCTCAGTGGAGACAAGTGGGA
AAACATGGTCCCACCTGTGCGAGACCCCCTGTCCTGTGCTGCTCACTCAACAACATCTTTGTGTTGCTTTCACCAGGCTGAGACCCTACC
CTATGGGGTATATGGGCTTTTACCTGTGCACCAGTGTGACAGGAAAGATTCATGTCACTACTGTCCGTGGCTACAATTCAAAGGTATCCA
ATGTCGCTGTAAATTTTATGGCACTATTTTTATTGGAGGATTTGGTCAGAATGCAGTTGTTGTACAACTCATAAATACTAACTGCTGATT
TTGACACATGTGTGCTCCAAATGATCTGGTGGTTATTTAACGTACCTCTTAAAATTCGTTGAAACGATTTCAGGTCAACTCTGAAGAGTA
TTTGAAAGCAGGACTTCAGAACAGTGTTTGATTTTTATTTTATAAATTTAAGCATTCAAATTAGGCAAATCTTTGGCTGCAGGCAGCAAA
AACAGCTGGACTTATTTAAAACAACTTGTTTTTGAGTTTTCTTATATATATATTGATTATTTGTTTTACACACATGCAGTAGCACTTTGG
TAAGAGTTAAAGAGTAAAGCAGCTTATGTTGTCAGGTCGTTCTTATCTAGAGAAGAGCTATAGCAGATCTCGGACAAACTCAGAATATAT
TCACTTTCATTTTTGACAGGATTCCCTCCACAACTCAGTTTCATATATTATTCCGTATTACATTTTTGCAGCTAAATTACCATAAAATGT
CAGCAAATGTAAAAATTTAATTTCTGAAAAGCACCATTAGCCCATTTCCCCCAAATTAAACGTAAATGTTTTTTTTCAGCACATGTTACC
ATGTCTGACCTGCAAAAATGCTGGAGAAAAATGAAGGAAAAAATTATGTTTTTCAGTTTAATTCTGTTAACTGAAGATATTCCAACTCAA
AACCAGCCTCATGCTCTGATTAGATAATCTTTTACATTGAACCTTTACTCTCAAAGCCATGTGTGGAGGGGGCTTGTCACTATTGTAGGC
TCACTGGATTGGTCATTTAGAGTTTCACAGACTCTTACCAGCATATATAGTATTTAATTGTTTCAAAAAAAATCAAACTGTAGTTGTTTT
GGCGATAGGTCTCACGCAACACATTTTTGTATGTGTGTGTGTGTGCGTGTGTGTGTGTGTGTGTGAAAAATTGCATTCATTGACTTCAGG
TAGATTAAGGTATCTTTTTATTCATTGCCCTCAGGAAAGTTAAGGTATCAATGAGACCCTTAAGCCAATCATGTAATAACTGCATGTGTC
TGGTCCAGGAGAAGTATTGAATAAGCCATTTCTACTGCTTACTCATGTCCCTATTTATGATTTCAACATGGATACATATTTCAGTTCTTT
CTTTTTCTCACTATCTGAAAATACATTTCCCTCCCTCTCTTCCCCCCAATATCTCCCTTTTTTTCTCTCTTCCTCTATCTTCCAAACCCC
ACTTTCTCCCTCCTCCTTTTCCTGTGTTCTCTTAAGCAGATAGCACATACCCCCACCCAGTACCAAATTTCAGAACACAAGAAGGTCCAG
TTCTTCCCCCTTCACATAAAGGAACATGGTTTGTCAGCCTTTCTCCTGTTTATGGGTTTCTTCCAGCAGAACAGAGACATTGCCAACCAT
ATTGGATCTGCTTGCTGTCCAAACCAGCAAACTTTCCTGGGCAAATCACAATCAGTGAGTAAATAGACAGCCTTTCTGCTGCCTTGGGTT
TCTGTGCAGATAAACAGAAATGCTCTGATTAGAAAGGAAATGAATGGTTCCACTCAAATGTCCTGCAATTTAGGATTGCAGATTTCTGCC
TTGAAATACCTGTTTCTTTGGGACATTCCGTCCTGATGATTTTTATTTTTGTTGGTTTTTATTTTTGGGGGGAATGACATGTTTGGGTCT
TTTATACATGAAAATTTGTTTGACAATAATCTCACAAAACATATTTTACATCTGAACAAAATGCCTTTTTGTTTACCGTAGCGTATACAT
TTGTTTTGGGATTTTTGTGTGTTTGTTGGGAATTTTGTTTTTAGCCAGGTCAGTATTGATGAGGCTGATCATTTGGCTCTTTTTTTCCTT
CCAGAAGAGTTGCATCAACAAAGTTAATTGTATTTATGTATGTAAATAGATTTTAAGCTTCATTATAAAATATTGTTAATGCCTATAACT
TTTTTTCAATTTTTTTGTGTGTGTTTCTAAGGACTTTTTCTTAGGTTTGCTAAATACTGTAGGGAAAAAAATGCTTCTTTCTACTTTGTT
TATTTTAGACTTTAAAATGAGCTACTTCTTATTCACTTTTGTAAACAGCTAATAGCATGGTTCCAATTTTTTTTAAGTTCACTTTTTTTG
TTCTAGGGGAAATGAATGTGCAAAAAAAGAAAAAGAACTGTTGGTTATTTGTGTTATTCTGGATGTATAAAAATCAATGGAAAAAAATAA
ACTTTCAAATTGAAATGACGGTATAACACATCTACTGAAAAAGCAACGGGAAATGTGGTCCTATTTAAGCCAGCCCCCACCTAGGGTCTA
TTTGTGTGGCAGTTATTGGGTTTGGTCACAAAACATCCTGAAAATTCGTGCGTGGGCTTCTTTCTCCCTGGTACAAACGTATGGAATGCT
TCTTAAAGGGGAACTGTCAAGCTGGTGTCTTCAGCCAGATGACATGAGAGAATATCCCAGAACCCTCTCTCCAAGGTGTTTCTAGATAGC
ACAGGAGAGCAGGCACTGCACTGTCCACAGTCCACGGTACACAGTCGGGTGGGCCGCCTCCCCTCTCCTGGGAGCATTCGTCGTGCCCAG
CCTGAGCAGGGCAGCTGGACTGCTGCTGTTCAGGAGCCACCAGAGCCTTCCTCTCTTTGTACCACAGTTTCTTCTGTAAATCCAGTGTTA

>In-frame_ENST00000313806_ENST00000344691_TCGA-N5-A4RT_RCAN1_chr21_35987059_-_RUNX1_chr21_36253010_length(amino acids)=490AA_start in transcript=2_stop in transcript=1474
LPPRDSEGVNGGAAGRARTGAREAPARKPGAARWGAQGRAGAGMEDGVAGPQLGAAAEAAEAAEARARPGVTLRPFAPLSGAAEADEGGG
DWSFIDCEMEEVDLQDLPSATIACHLDPRVFVDGLCRVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRG
KSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFN
PQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYP
GAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSA

--------------------------------------------------------------
>In-frame_ENST00000313806_ENST00000325074_TCGA-N5-A4RT_RCAN1_chr21_35987059_-_RUNX1_chr21_36253010_length(transcript)=5809nt_BP=383nt
GCCTGCCGCCGCGCGATTCCGAGGGGGTTAACGGCGGAGCCGCCGGCCGGGCGCGGACCGGAGCGCGTGAGGCTCCGGCGCGCAAGCCCG
GAGCAGCCCGCTGGGGCGCACAGGGTCGCGCGGGCGCGGGGATGGAGGACGGCGTGGCCGGTCCCCAGCTCGGGGCCGCGGCGGAGGCGG
CGGAGGCGGCCGAGGCGCGAGCGCGGCCCGGGGTGACGCTGCGGCCCTTCGCGCCCCTCTCGGGGGCGGCCGAGGCGGACGAGGGCGGCG
GCGACTGGAGCTTCATTGACTGCGAGATGGAGGAGGTGGACCTGCAGGACCTGCCCAGCGCCACCATCGCCTGTCACCTGGACCCGCGCG
TGTTCGTGGACGGCCTGTGCCGGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACTGTGATGGCTGGCAATGATGAAAACT
ACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTCAGGTTTGTCGGTCGAAGTGGAAGAG
GGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGAGCCATCAAAATCACAGTGGATGGGC
CCCGAGAACCTCGAAGACATCGGCAGAAACTAGATGATCAGACCAAGCCCGGGAGCTTGTCCTTTTCCGAGCGGCTCAGTGAACTGGAGC
AGCTGCGGCGCACAGCCATGAGGGTCAGCCCACACCACCCAGCCCCCACGCCCAACCCTCGTGCCTCCCTGAACCACTCCACTGCCTTTA
ACCCTCAGCCTCAGAGTCAGATGCAGGATACAAGGCAGATCCAACCATCCCCACCGTGGTCCTACGATCAGTCCTACCAATACCTGGGAT
CCATTGCCTCTCCTTCTGTGCACCCAGCAACGCCCATTTCACCTGGACGTGCCAGCGGCATGACAACCCTCTCTGCAGAACTTTCCAGTC
GACTCTCAACGGCACCCGACCTGACAGCGTTCAGCGACCCGCGCCAGTTCCCCGCGCTGCCCTCCATCTCCGACCCCCGCATGCACTATC
CAGGCGCCTTCACCTACTCCCCGACGCCGGTCACCTCGGGCATCGGCATCGGCATGTCGGCCATGGGCTCGGCCACGCGCTACCACACCT
ACCTGCCGCCGCCCTACCCCGGCTCGTCGCAAGCGCAGGGAGGCCCGTTCCAAGCCAGCTCGCCCTCCTACCACCTGTACTACGGCGCCT
CGGCCGGCTCCTACCAGTTCTCCATGGTGGGCGGCGAGCGCTCGCCGCCGCGCATCCTGCCGCCCTGCACCAACGCCTCCACCGGCTCCG
CGCTGCTCAACCCCAGCCTCCCGAACCAGAGCGACGTGGTGGAGGCCGAGGGCAGCCACAGCAACTCCCCCACCAACATGGCGCCCTCCG
CGCGCCTGGAGGAGGCCGTGTGGAGGCCCTACTGAGGCGCCAGGCCTGGCCCGGCTGGGCCCCGCGGGCCGCCGCCTTCGCCTCCGGGCG
CGCGGGCCTCCTGTTCGCGACAAGCCCGCCGGGATCCCGGGCCCTGGGCCCGGCCACCGTCCTGGGGCCGAGGGCGCCCGACGGCCAGGA
TCTCGCTGTAGGTCAGGCCCGCGCAGCCTCCTGCGCCCAGAAGCCCACGCCGCCGCCGTCTGCTGGCGCCCCGGCCCTCGCGGAGGTGTC
CGAGGCGACGCACCTCGAGGGTGTCCGCCGGCCCCAGCACCCAGGGGACGCGCTGGAAAGCAAACAGGAAGATTCCCGGAGGGAAACTGT
GAATGCTTCTGATTTAGCAATGCTGTGAATAAAAAGAAAGATTTTATACCCTTGACTTAACTTTTTAACCAAGTTGTTTATTCCAAAGAG
TGTGGAATTTTGGTTGGGGTGGGGGGAGAGGAGGGATGCAACTCGCCCTGTTTGGCATCTAATTCTTATTTTTAATTTTTCCGCACCTTA
TCAATTGCAAAATGCGTATTTGCATTTGGGTGGTTTTTATTTTTATATACGTTTATATAAATATATATAAATTGAGCTTGCTTCTTTCTT
GCTTTGACCATGGAAAGAAATATGATTCCCTTTTCTTTAAGTTTTATTTAACTTTTCTTTTGGACTTTTGGGTAGTTGTTTTTTTTTGTT
TTGTTTTGTTTTTTTGAGAAACAGCTACAGCTTTGGGTCATTTTTAACTACTGTATTCCCACAAGGAATCCCCAGATATTTATGTATCTT
GATGTTCAGACATTTATGTGTTGATAATTTTTTAATTATTTAAATGTACTTATATTAAGAAAAATATCAAGTACTACATTTTCTTTTGTT
CTTGATAGTAGCCAAAGTTAAATGTATCACATTGAAGAAGGCTAGAAAAAAAGAATGAGTAATGTGATCGCTTGGTTATCCAGAAGTATT
GTTTACATTAAACTCCCTTTCATGTTAATCAAACAAGTGAGTAGCTCACGCAGCAACGTTTTTAATAGGATTTTTAGACACTGAGGGTCA
CTCCAAGGATCAGAAGTATGGAATTTTCTGCCAGGCTCAACAAGGGTCTCATATCTAACTTCCTCCTTAAAACAGAGAAGGTCAATCTAG
TTCCAGAGGGTTGAGGCAGGTGCCAATAATTACATCTTTGGAGAGGATTTGATTTCTGCCCAGGGATTTGCTCACCCCAAGGTCATCTGA
TAATTTCACAGATGCTGTGTAACAGAACACAGCCAAAGTAAACTGTGTAGGGGAGCCACATTTACATAGGAACCAAATCAATGAATTTAG
GGGTTACGATTATAGCAATTTAAGGGCCCACCAGAAGCAGGCCTCGAGGAGTCAATTTGCCTCTGTGTGCCTCAGTGGAGACAAGTGGGA
AAACATGGTCCCACCTGTGCGAGACCCCCTGTCCTGTGCTGCTCACTCAACAACATCTTTGTGTTGCTTTCACCAGGCTGAGACCCTACC
CTATGGGGTATATGGGCTTTTACCTGTGCACCAGTGTGACAGGAAAGATTCATGTCACTACTGTCCGTGGCTACAATTCAAAGGTATCCA
ATGTCGCTGTAAATTTTATGGCACTATTTTTATTGGAGGATTTGGTCAGAATGCAGTTGTTGTACAACTCATAAATACTAACTGCTGATT
TTGACACATGTGTGCTCCAAATGATCTGGTGGTTATTTAACGTACCTCTTAAAATTCGTTGAAACGATTTCAGGTCAACTCTGAAGAGTA
TTTGAAAGCAGGACTTCAGAACAGTGTTTGATTTTTATTTTATAAATTTAAGCATTCAAATTAGGCAAATCTTTGGCTGCAGGCAGCAAA
AACAGCTGGACTTATTTAAAACAACTTGTTTTTGAGTTTTCTTATATATATATTGATTATTTGTTTTACACACATGCAGTAGCACTTTGG
TAAGAGTTAAAGAGTAAAGCAGCTTATGTTGTCAGGTCGTTCTTATCTAGAGAAGAGCTATAGCAGATCTCGGACAAACTCAGAATATAT
TCACTTTCATTTTTGACAGGATTCCCTCCACAACTCAGTTTCATATATTATTCCGTATTACATTTTTGCAGCTAAATTACCATAAAATGT
CAGCAAATGTAAAAATTTAATTTCTGAAAAGCACCATTAGCCCATTTCCCCCAAATTAAACGTAAATGTTTTTTTTCAGCACATGTTACC
ATGTCTGACCTGCAAAAATGCTGGAGAAAAATGAAGGAAAAAATTATGTTTTTCAGTTTAATTCTGTTAACTGAAGATATTCCAACTCAA
AACCAGCCTCATGCTCTGATTAGATAATCTTTTACATTGAACCTTTACTCTCAAAGCCATGTGTGGAGGGGGCTTGTCACTATTGTAGGC
TCACTGGATTGGTCATTTAGAGTTTCACAGACTCTTACCAGCATATATAGTATTTAATTGTTTCAAAAAAAATCAAACTGTAGTTGTTTT
GGCGATAGGTCTCACGCAACACATTTTTGTATGTGTGTGTGTGTGCGTGTGTGTGTGTGTGTGTGAAAAATTGCATTCATTGACTTCAGG
TAGATTAAGGTATCTTTTTATTCATTGCCCTCAGGAAAGTTAAGGTATCAATGAGACCCTTAAGCCAATCATGTAATAACTGCATGTGTC
TGGTCCAGGAGAAGTATTGAATAAGCCATTTCTACTGCTTACTCATGTCCCTATTTATGATTTCAACATGGATACATATTTCAGTTCTTT
CTTTTTCTCACTATCTGAAAATACATTTCCCTCCCTCTCTTCCCCCCAATATCTCCCTTTTTTTCTCTCTTCCTCTATCTTCCAAACCCC
ACTTTCTCCCTCCTCCTTTTCCTGTGTTCTCTTAAGCAGATAGCACATACCCCCACCCAGTACCAAATTTCAGAACACAAGAAGGTCCAG
TTCTTCCCCCTTCACATAAAGGAACATGGTTTGTCAGCCTTTCTCCTGTTTATGGGTTTCTTCCAGCAGAACAGAGACATTGCCAACCAT
ATTGGATCTGCTTGCTGTCCAAACCAGCAAACTTTCCTGGGCAAATCACAATCAGTGAGTAAATAGACAGCCTTTCTGCTGCCTTGGGTT
TCTGTGCAGATAAACAGAAATGCTCTGATTAGAAAGGAAATGAATGGTTCCACTCAAATGTCCTGCAATTTAGGATTGCAGATTTCTGCC
TTGAAATACCTGTTTCTTTGGGACATTCCGTCCTGATGATTTTTATTTTTGTTGGTTTTTATTTTTGGGGGGAATGACATGTTTGGGTCT
TTTATACATGAAAATTTGTTTGACAATAATCTCACAAAACATATTTTACATCTGAACAAAATGCCTTTTTGTTTACCGTAGCGTATACAT
TTGTTTTGGGATTTTTGTGTGTTTGTTGGGAATTTTGTTTTTAGCCAGGTCAGTATTGATGAGGCTGATCATTTGGCTCTTTTTTTCCTT
CCAGAAGAGTTGCATCAACAAAGTTAATTGTATTTATGTATGTAAATAGATTTTAAGCTTCATTATAAAATATTGTTAATGCCTATAACT
TTTTTTCAATTTTTTTGTGTGTGTTTCTAAGGACTTTTTCTTAGGTTTGCTAAATACTGTAGGGAAAAAAATGCTTCTTTCTACTTTGTT
TATTTTAGACTTTAAAATGAGCTACTTCTTATTCACTTTTGTAAACAGCTAATAGCATGGTTCCAATTTTTTTTAAGTTCACTTTTTTTG
TTCTAGGGGAAATGAATGTGCAAAAAAAGAAAAAGAACTGTTGGTTATTTGTGTTATTCTGGATGTATAAAAATCAATGGAAAAAAATAA
ACTTTCAAATTGAAATGACGGTATAACACATCTACTGAAAAAGCAACGGGAAATGTGGTCCTATTTAAGCCAGCCCCCACCTAGGGTCTA
TTTGTGTGGCAGTTATTGGGTTTGGTCACAAAACATCCTGAAAATTCGTGCGTGGGCTTCTTTCTCCCTGGTACAAACGTATGGAATGCT
TCTTAAAGGGGAACTGTCAAGCTGGTGTCTTCAGCCAGATGACATGAGAGAATATCCCAGAACCCTCTCTCCAAGGTGTTTCTAGATAGC
ACAGGAGAGCAGGCACTGCACTGTCCACAGTCCACGGTACACAGTCGGGTGGGCCGCCTCCCCTCTCCTGGGAGCATTCGTCGTGCCCAG
CCTGAGCAGGGCAGCTGGACTGCTGCTGTTCAGGAGCCACCAGAGCCTTCCTCTCTTTGTACCACAGTTTCTTCTGTAAATCCAGTGTTA

>In-frame_ENST00000313806_ENST00000325074_TCGA-N5-A4RT_RCAN1_chr21_35987059_-_RUNX1_chr21_36253010_length(amino acids)=490AA_start in transcript=2_stop in transcript=1474
LPPRDSEGVNGGAAGRARTGAREAPARKPGAARWGAQGRAGAGMEDGVAGPQLGAAAEAAEAAEARARPGVTLRPFAPLSGAAEADEGGG
DWSFIDCEMEEVDLQDLPSATIACHLDPRVFVDGLCRVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRG
KSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFN
PQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYP
GAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSA

--------------------------------------------------------------
>In-frame_ENST00000313806_ENST00000437180_TCGA-N5-A4RT_RCAN1_chr21_35987059_-_RUNX1_chr21_36253010_length(transcript)=5809nt_BP=383nt
GCCTGCCGCCGCGCGATTCCGAGGGGGTTAACGGCGGAGCCGCCGGCCGGGCGCGGACCGGAGCGCGTGAGGCTCCGGCGCGCAAGCCCG
GAGCAGCCCGCTGGGGCGCACAGGGTCGCGCGGGCGCGGGGATGGAGGACGGCGTGGCCGGTCCCCAGCTCGGGGCCGCGGCGGAGGCGG
CGGAGGCGGCCGAGGCGCGAGCGCGGCCCGGGGTGACGCTGCGGCCCTTCGCGCCCCTCTCGGGGGCGGCCGAGGCGGACGAGGGCGGCG
GCGACTGGAGCTTCATTGACTGCGAGATGGAGGAGGTGGACCTGCAGGACCTGCCCAGCGCCACCATCGCCTGTCACCTGGACCCGCGCG
TGTTCGTGGACGGCCTGTGCCGGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACTGTGATGGCTGGCAATGATGAAAACT
ACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTCAGGTTTGTCGGTCGAAGTGGAAGAG
GGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGAGCCATCAAAATCACAGTGGATGGGC
CCCGAGAACCTCGAAGACATCGGCAGAAACTAGATGATCAGACCAAGCCCGGGAGCTTGTCCTTTTCCGAGCGGCTCAGTGAACTGGAGC
AGCTGCGGCGCACAGCCATGAGGGTCAGCCCACACCACCCAGCCCCCACGCCCAACCCTCGTGCCTCCCTGAACCACTCCACTGCCTTTA
ACCCTCAGCCTCAGAGTCAGATGCAGGATACAAGGCAGATCCAACCATCCCCACCGTGGTCCTACGATCAGTCCTACCAATACCTGGGAT
CCATTGCCTCTCCTTCTGTGCACCCAGCAACGCCCATTTCACCTGGACGTGCCAGCGGCATGACAACCCTCTCTGCAGAACTTTCCAGTC
GACTCTCAACGGCACCCGACCTGACAGCGTTCAGCGACCCGCGCCAGTTCCCCGCGCTGCCCTCCATCTCCGACCCCCGCATGCACTATC
CAGGCGCCTTCACCTACTCCCCGACGCCGGTCACCTCGGGCATCGGCATCGGCATGTCGGCCATGGGCTCGGCCACGCGCTACCACACCT
ACCTGCCGCCGCCCTACCCCGGCTCGTCGCAAGCGCAGGGAGGCCCGTTCCAAGCCAGCTCGCCCTCCTACCACCTGTACTACGGCGCCT
CGGCCGGCTCCTACCAGTTCTCCATGGTGGGCGGCGAGCGCTCGCCGCCGCGCATCCTGCCGCCCTGCACCAACGCCTCCACCGGCTCCG
CGCTGCTCAACCCCAGCCTCCCGAACCAGAGCGACGTGGTGGAGGCCGAGGGCAGCCACAGCAACTCCCCCACCAACATGGCGCCCTCCG
CGCGCCTGGAGGAGGCCGTGTGGAGGCCCTACTGAGGCGCCAGGCCTGGCCCGGCTGGGCCCCGCGGGCCGCCGCCTTCGCCTCCGGGCG
CGCGGGCCTCCTGTTCGCGACAAGCCCGCCGGGATCCCGGGCCCTGGGCCCGGCCACCGTCCTGGGGCCGAGGGCGCCCGACGGCCAGGA
TCTCGCTGTAGGTCAGGCCCGCGCAGCCTCCTGCGCCCAGAAGCCCACGCCGCCGCCGTCTGCTGGCGCCCCGGCCCTCGCGGAGGTGTC
CGAGGCGACGCACCTCGAGGGTGTCCGCCGGCCCCAGCACCCAGGGGACGCGCTGGAAAGCAAACAGGAAGATTCCCGGAGGGAAACTGT
GAATGCTTCTGATTTAGCAATGCTGTGAATAAAAAGAAAGATTTTATACCCTTGACTTAACTTTTTAACCAAGTTGTTTATTCCAAAGAG
TGTGGAATTTTGGTTGGGGTGGGGGGAGAGGAGGGATGCAACTCGCCCTGTTTGGCATCTAATTCTTATTTTTAATTTTTCCGCACCTTA
TCAATTGCAAAATGCGTATTTGCATTTGGGTGGTTTTTATTTTTATATACGTTTATATAAATATATATAAATTGAGCTTGCTTCTTTCTT
GCTTTGACCATGGAAAGAAATATGATTCCCTTTTCTTTAAGTTTTATTTAACTTTTCTTTTGGACTTTTGGGTAGTTGTTTTTTTTTGTT
TTGTTTTGTTTTTTTGAGAAACAGCTACAGCTTTGGGTCATTTTTAACTACTGTATTCCCACAAGGAATCCCCAGATATTTATGTATCTT
GATGTTCAGACATTTATGTGTTGATAATTTTTTAATTATTTAAATGTACTTATATTAAGAAAAATATCAAGTACTACATTTTCTTTTGTT
CTTGATAGTAGCCAAAGTTAAATGTATCACATTGAAGAAGGCTAGAAAAAAAGAATGAGTAATGTGATCGCTTGGTTATCCAGAAGTATT
GTTTACATTAAACTCCCTTTCATGTTAATCAAACAAGTGAGTAGCTCACGCAGCAACGTTTTTAATAGGATTTTTAGACACTGAGGGTCA
CTCCAAGGATCAGAAGTATGGAATTTTCTGCCAGGCTCAACAAGGGTCTCATATCTAACTTCCTCCTTAAAACAGAGAAGGTCAATCTAG
TTCCAGAGGGTTGAGGCAGGTGCCAATAATTACATCTTTGGAGAGGATTTGATTTCTGCCCAGGGATTTGCTCACCCCAAGGTCATCTGA
TAATTTCACAGATGCTGTGTAACAGAACACAGCCAAAGTAAACTGTGTAGGGGAGCCACATTTACATAGGAACCAAATCAATGAATTTAG
GGGTTACGATTATAGCAATTTAAGGGCCCACCAGAAGCAGGCCTCGAGGAGTCAATTTGCCTCTGTGTGCCTCAGTGGAGACAAGTGGGA
AAACATGGTCCCACCTGTGCGAGACCCCCTGTCCTGTGCTGCTCACTCAACAACATCTTTGTGTTGCTTTCACCAGGCTGAGACCCTACC
CTATGGGGTATATGGGCTTTTACCTGTGCACCAGTGTGACAGGAAAGATTCATGTCACTACTGTCCGTGGCTACAATTCAAAGGTATCCA
ATGTCGCTGTAAATTTTATGGCACTATTTTTATTGGAGGATTTGGTCAGAATGCAGTTGTTGTACAACTCATAAATACTAACTGCTGATT
TTGACACATGTGTGCTCCAAATGATCTGGTGGTTATTTAACGTACCTCTTAAAATTCGTTGAAACGATTTCAGGTCAACTCTGAAGAGTA
TTTGAAAGCAGGACTTCAGAACAGTGTTTGATTTTTATTTTATAAATTTAAGCATTCAAATTAGGCAAATCTTTGGCTGCAGGCAGCAAA
AACAGCTGGACTTATTTAAAACAACTTGTTTTTGAGTTTTCTTATATATATATTGATTATTTGTTTTACACACATGCAGTAGCACTTTGG
TAAGAGTTAAAGAGTAAAGCAGCTTATGTTGTCAGGTCGTTCTTATCTAGAGAAGAGCTATAGCAGATCTCGGACAAACTCAGAATATAT
TCACTTTCATTTTTGACAGGATTCCCTCCACAACTCAGTTTCATATATTATTCCGTATTACATTTTTGCAGCTAAATTACCATAAAATGT
CAGCAAATGTAAAAATTTAATTTCTGAAAAGCACCATTAGCCCATTTCCCCCAAATTAAACGTAAATGTTTTTTTTCAGCACATGTTACC
ATGTCTGACCTGCAAAAATGCTGGAGAAAAATGAAGGAAAAAATTATGTTTTTCAGTTTAATTCTGTTAACTGAAGATATTCCAACTCAA
AACCAGCCTCATGCTCTGATTAGATAATCTTTTACATTGAACCTTTACTCTCAAAGCCATGTGTGGAGGGGGCTTGTCACTATTGTAGGC
TCACTGGATTGGTCATTTAGAGTTTCACAGACTCTTACCAGCATATATAGTATTTAATTGTTTCAAAAAAAATCAAACTGTAGTTGTTTT
GGCGATAGGTCTCACGCAACACATTTTTGTATGTGTGTGTGTGTGCGTGTGTGTGTGTGTGTGTGAAAAATTGCATTCATTGACTTCAGG
TAGATTAAGGTATCTTTTTATTCATTGCCCTCAGGAAAGTTAAGGTATCAATGAGACCCTTAAGCCAATCATGTAATAACTGCATGTGTC
TGGTCCAGGAGAAGTATTGAATAAGCCATTTCTACTGCTTACTCATGTCCCTATTTATGATTTCAACATGGATACATATTTCAGTTCTTT
CTTTTTCTCACTATCTGAAAATACATTTCCCTCCCTCTCTTCCCCCCAATATCTCCCTTTTTTTCTCTCTTCCTCTATCTTCCAAACCCC
ACTTTCTCCCTCCTCCTTTTCCTGTGTTCTCTTAAGCAGATAGCACATACCCCCACCCAGTACCAAATTTCAGAACACAAGAAGGTCCAG
TTCTTCCCCCTTCACATAAAGGAACATGGTTTGTCAGCCTTTCTCCTGTTTATGGGTTTCTTCCAGCAGAACAGAGACATTGCCAACCAT
ATTGGATCTGCTTGCTGTCCAAACCAGCAAACTTTCCTGGGCAAATCACAATCAGTGAGTAAATAGACAGCCTTTCTGCTGCCTTGGGTT
TCTGTGCAGATAAACAGAAATGCTCTGATTAGAAAGGAAATGAATGGTTCCACTCAAATGTCCTGCAATTTAGGATTGCAGATTTCTGCC
TTGAAATACCTGTTTCTTTGGGACATTCCGTCCTGATGATTTTTATTTTTGTTGGTTTTTATTTTTGGGGGGAATGACATGTTTGGGTCT
TTTATACATGAAAATTTGTTTGACAATAATCTCACAAAACATATTTTACATCTGAACAAAATGCCTTTTTGTTTACCGTAGCGTATACAT
TTGTTTTGGGATTTTTGTGTGTTTGTTGGGAATTTTGTTTTTAGCCAGGTCAGTATTGATGAGGCTGATCATTTGGCTCTTTTTTTCCTT
CCAGAAGAGTTGCATCAACAAAGTTAATTGTATTTATGTATGTAAATAGATTTTAAGCTTCATTATAAAATATTGTTAATGCCTATAACT
TTTTTTCAATTTTTTTGTGTGTGTTTCTAAGGACTTTTTCTTAGGTTTGCTAAATACTGTAGGGAAAAAAATGCTTCTTTCTACTTTGTT
TATTTTAGACTTTAAAATGAGCTACTTCTTATTCACTTTTGTAAACAGCTAATAGCATGGTTCCAATTTTTTTTAAGTTCACTTTTTTTG
TTCTAGGGGAAATGAATGTGCAAAAAAAGAAAAAGAACTGTTGGTTATTTGTGTTATTCTGGATGTATAAAAATCAATGGAAAAAAATAA
ACTTTCAAATTGAAATGACGGTATAACACATCTACTGAAAAAGCAACGGGAAATGTGGTCCTATTTAAGCCAGCCCCCACCTAGGGTCTA
TTTGTGTGGCAGTTATTGGGTTTGGTCACAAAACATCCTGAAAATTCGTGCGTGGGCTTCTTTCTCCCTGGTACAAACGTATGGAATGCT
TCTTAAAGGGGAACTGTCAAGCTGGTGTCTTCAGCCAGATGACATGAGAGAATATCCCAGAACCCTCTCTCCAAGGTGTTTCTAGATAGC
ACAGGAGAGCAGGCACTGCACTGTCCACAGTCCACGGTACACAGTCGGGTGGGCCGCCTCCCCTCTCCTGGGAGCATTCGTCGTGCCCAG
CCTGAGCAGGGCAGCTGGACTGCTGCTGTTCAGGAGCCACCAGAGCCTTCCTCTCTTTGTACCACAGTTTCTTCTGTAAATCCAGTGTTA

>In-frame_ENST00000313806_ENST00000437180_TCGA-N5-A4RT_RCAN1_chr21_35987059_-_RUNX1_chr21_36253010_length(amino acids)=490AA_start in transcript=2_stop in transcript=1474
LPPRDSEGVNGGAAGRARTGAREAPARKPGAARWGAQGRAGAGMEDGVAGPQLGAAAEAAEAAEARARPGVTLRPFAPLSGAAEADEGGG
DWSFIDCEMEEVDLQDLPSATIACHLDPRVFVDGLCRVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRG
KSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFN
PQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYP
GAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSA

--------------------------------------------------------------
>In-frame_ENST00000313806_ENST00000300305_TCGA-N5-A4RT_RCAN1_chr21_35987059_-_RUNX1_chr21_36253010_length(transcript)=5809nt_BP=383nt
GCCTGCCGCCGCGCGATTCCGAGGGGGTTAACGGCGGAGCCGCCGGCCGGGCGCGGACCGGAGCGCGTGAGGCTCCGGCGCGCAAGCCCG
GAGCAGCCCGCTGGGGCGCACAGGGTCGCGCGGGCGCGGGGATGGAGGACGGCGTGGCCGGTCCCCAGCTCGGGGCCGCGGCGGAGGCGG
CGGAGGCGGCCGAGGCGCGAGCGCGGCCCGGGGTGACGCTGCGGCCCTTCGCGCCCCTCTCGGGGGCGGCCGAGGCGGACGAGGGCGGCG
GCGACTGGAGCTTCATTGACTGCGAGATGGAGGAGGTGGACCTGCAGGACCTGCCCAGCGCCACCATCGCCTGTCACCTGGACCCGCGCG
TGTTCGTGGACGGCCTGTGCCGGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACTGTGATGGCTGGCAATGATGAAAACT
ACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTCAGGTTTGTCGGTCGAAGTGGAAGAG
GGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGAGCCATCAAAATCACAGTGGATGGGC
CCCGAGAACCTCGAAGACATCGGCAGAAACTAGATGATCAGACCAAGCCCGGGAGCTTGTCCTTTTCCGAGCGGCTCAGTGAACTGGAGC
AGCTGCGGCGCACAGCCATGAGGGTCAGCCCACACCACCCAGCCCCCACGCCCAACCCTCGTGCCTCCCTGAACCACTCCACTGCCTTTA
ACCCTCAGCCTCAGAGTCAGATGCAGGATACAAGGCAGATCCAACCATCCCCACCGTGGTCCTACGATCAGTCCTACCAATACCTGGGAT
CCATTGCCTCTCCTTCTGTGCACCCAGCAACGCCCATTTCACCTGGACGTGCCAGCGGCATGACAACCCTCTCTGCAGAACTTTCCAGTC
GACTCTCAACGGCACCCGACCTGACAGCGTTCAGCGACCCGCGCCAGTTCCCCGCGCTGCCCTCCATCTCCGACCCCCGCATGCACTATC
CAGGCGCCTTCACCTACTCCCCGACGCCGGTCACCTCGGGCATCGGCATCGGCATGTCGGCCATGGGCTCGGCCACGCGCTACCACACCT
ACCTGCCGCCGCCCTACCCCGGCTCGTCGCAAGCGCAGGGAGGCCCGTTCCAAGCCAGCTCGCCCTCCTACCACCTGTACTACGGCGCCT
CGGCCGGCTCCTACCAGTTCTCCATGGTGGGCGGCGAGCGCTCGCCGCCGCGCATCCTGCCGCCCTGCACCAACGCCTCCACCGGCTCCG
CGCTGCTCAACCCCAGCCTCCCGAACCAGAGCGACGTGGTGGAGGCCGAGGGCAGCCACAGCAACTCCCCCACCAACATGGCGCCCTCCG
CGCGCCTGGAGGAGGCCGTGTGGAGGCCCTACTGAGGCGCCAGGCCTGGCCCGGCTGGGCCCCGCGGGCCGCCGCCTTCGCCTCCGGGCG
CGCGGGCCTCCTGTTCGCGACAAGCCCGCCGGGATCCCGGGCCCTGGGCCCGGCCACCGTCCTGGGGCCGAGGGCGCCCGACGGCCAGGA
TCTCGCTGTAGGTCAGGCCCGCGCAGCCTCCTGCGCCCAGAAGCCCACGCCGCCGCCGTCTGCTGGCGCCCCGGCCCTCGCGGAGGTGTC
CGAGGCGACGCACCTCGAGGGTGTCCGCCGGCCCCAGCACCCAGGGGACGCGCTGGAAAGCAAACAGGAAGATTCCCGGAGGGAAACTGT
GAATGCTTCTGATTTAGCAATGCTGTGAATAAAAAGAAAGATTTTATACCCTTGACTTAACTTTTTAACCAAGTTGTTTATTCCAAAGAG
TGTGGAATTTTGGTTGGGGTGGGGGGAGAGGAGGGATGCAACTCGCCCTGTTTGGCATCTAATTCTTATTTTTAATTTTTCCGCACCTTA
TCAATTGCAAAATGCGTATTTGCATTTGGGTGGTTTTTATTTTTATATACGTTTATATAAATATATATAAATTGAGCTTGCTTCTTTCTT
GCTTTGACCATGGAAAGAAATATGATTCCCTTTTCTTTAAGTTTTATTTAACTTTTCTTTTGGACTTTTGGGTAGTTGTTTTTTTTTGTT
TTGTTTTGTTTTTTTGAGAAACAGCTACAGCTTTGGGTCATTTTTAACTACTGTATTCCCACAAGGAATCCCCAGATATTTATGTATCTT
GATGTTCAGACATTTATGTGTTGATAATTTTTTAATTATTTAAATGTACTTATATTAAGAAAAATATCAAGTACTACATTTTCTTTTGTT
CTTGATAGTAGCCAAAGTTAAATGTATCACATTGAAGAAGGCTAGAAAAAAAGAATGAGTAATGTGATCGCTTGGTTATCCAGAAGTATT
GTTTACATTAAACTCCCTTTCATGTTAATCAAACAAGTGAGTAGCTCACGCAGCAACGTTTTTAATAGGATTTTTAGACACTGAGGGTCA
CTCCAAGGATCAGAAGTATGGAATTTTCTGCCAGGCTCAACAAGGGTCTCATATCTAACTTCCTCCTTAAAACAGAGAAGGTCAATCTAG
TTCCAGAGGGTTGAGGCAGGTGCCAATAATTACATCTTTGGAGAGGATTTGATTTCTGCCCAGGGATTTGCTCACCCCAAGGTCATCTGA
TAATTTCACAGATGCTGTGTAACAGAACACAGCCAAAGTAAACTGTGTAGGGGAGCCACATTTACATAGGAACCAAATCAATGAATTTAG
GGGTTACGATTATAGCAATTTAAGGGCCCACCAGAAGCAGGCCTCGAGGAGTCAATTTGCCTCTGTGTGCCTCAGTGGAGACAAGTGGGA
AAACATGGTCCCACCTGTGCGAGACCCCCTGTCCTGTGCTGCTCACTCAACAACATCTTTGTGTTGCTTTCACCAGGCTGAGACCCTACC
CTATGGGGTATATGGGCTTTTACCTGTGCACCAGTGTGACAGGAAAGATTCATGTCACTACTGTCCGTGGCTACAATTCAAAGGTATCCA
ATGTCGCTGTAAATTTTATGGCACTATTTTTATTGGAGGATTTGGTCAGAATGCAGTTGTTGTACAACTCATAAATACTAACTGCTGATT
TTGACACATGTGTGCTCCAAATGATCTGGTGGTTATTTAACGTACCTCTTAAAATTCGTTGAAACGATTTCAGGTCAACTCTGAAGAGTA
TTTGAAAGCAGGACTTCAGAACAGTGTTTGATTTTTATTTTATAAATTTAAGCATTCAAATTAGGCAAATCTTTGGCTGCAGGCAGCAAA
AACAGCTGGACTTATTTAAAACAACTTGTTTTTGAGTTTTCTTATATATATATTGATTATTTGTTTTACACACATGCAGTAGCACTTTGG
TAAGAGTTAAAGAGTAAAGCAGCTTATGTTGTCAGGTCGTTCTTATCTAGAGAAGAGCTATAGCAGATCTCGGACAAACTCAGAATATAT
TCACTTTCATTTTTGACAGGATTCCCTCCACAACTCAGTTTCATATATTATTCCGTATTACATTTTTGCAGCTAAATTACCATAAAATGT
CAGCAAATGTAAAAATTTAATTTCTGAAAAGCACCATTAGCCCATTTCCCCCAAATTAAACGTAAATGTTTTTTTTCAGCACATGTTACC
ATGTCTGACCTGCAAAAATGCTGGAGAAAAATGAAGGAAAAAATTATGTTTTTCAGTTTAATTCTGTTAACTGAAGATATTCCAACTCAA
AACCAGCCTCATGCTCTGATTAGATAATCTTTTACATTGAACCTTTACTCTCAAAGCCATGTGTGGAGGGGGCTTGTCACTATTGTAGGC
TCACTGGATTGGTCATTTAGAGTTTCACAGACTCTTACCAGCATATATAGTATTTAATTGTTTCAAAAAAAATCAAACTGTAGTTGTTTT
GGCGATAGGTCTCACGCAACACATTTTTGTATGTGTGTGTGTGTGCGTGTGTGTGTGTGTGTGTGAAAAATTGCATTCATTGACTTCAGG
TAGATTAAGGTATCTTTTTATTCATTGCCCTCAGGAAAGTTAAGGTATCAATGAGACCCTTAAGCCAATCATGTAATAACTGCATGTGTC
TGGTCCAGGAGAAGTATTGAATAAGCCATTTCTACTGCTTACTCATGTCCCTATTTATGATTTCAACATGGATACATATTTCAGTTCTTT
CTTTTTCTCACTATCTGAAAATACATTTCCCTCCCTCTCTTCCCCCCAATATCTCCCTTTTTTTCTCTCTTCCTCTATCTTCCAAACCCC
ACTTTCTCCCTCCTCCTTTTCCTGTGTTCTCTTAAGCAGATAGCACATACCCCCACCCAGTACCAAATTTCAGAACACAAGAAGGTCCAG
TTCTTCCCCCTTCACATAAAGGAACATGGTTTGTCAGCCTTTCTCCTGTTTATGGGTTTCTTCCAGCAGAACAGAGACATTGCCAACCAT
ATTGGATCTGCTTGCTGTCCAAACCAGCAAACTTTCCTGGGCAAATCACAATCAGTGAGTAAATAGACAGCCTTTCTGCTGCCTTGGGTT
TCTGTGCAGATAAACAGAAATGCTCTGATTAGAAAGGAAATGAATGGTTCCACTCAAATGTCCTGCAATTTAGGATTGCAGATTTCTGCC
TTGAAATACCTGTTTCTTTGGGACATTCCGTCCTGATGATTTTTATTTTTGTTGGTTTTTATTTTTGGGGGGAATGACATGTTTGGGTCT
TTTATACATGAAAATTTGTTTGACAATAATCTCACAAAACATATTTTACATCTGAACAAAATGCCTTTTTGTTTACCGTAGCGTATACAT
TTGTTTTGGGATTTTTGTGTGTTTGTTGGGAATTTTGTTTTTAGCCAGGTCAGTATTGATGAGGCTGATCATTTGGCTCTTTTTTTCCTT
CCAGAAGAGTTGCATCAACAAAGTTAATTGTATTTATGTATGTAAATAGATTTTAAGCTTCATTATAAAATATTGTTAATGCCTATAACT
TTTTTTCAATTTTTTTGTGTGTGTTTCTAAGGACTTTTTCTTAGGTTTGCTAAATACTGTAGGGAAAAAAATGCTTCTTTCTACTTTGTT
TATTTTAGACTTTAAAATGAGCTACTTCTTATTCACTTTTGTAAACAGCTAATAGCATGGTTCCAATTTTTTTTAAGTTCACTTTTTTTG
TTCTAGGGGAAATGAATGTGCAAAAAAAGAAAAAGAACTGTTGGTTATTTGTGTTATTCTGGATGTATAAAAATCAATGGAAAAAAATAA
ACTTTCAAATTGAAATGACGGTATAACACATCTACTGAAAAAGCAACGGGAAATGTGGTCCTATTTAAGCCAGCCCCCACCTAGGGTCTA
TTTGTGTGGCAGTTATTGGGTTTGGTCACAAAACATCCTGAAAATTCGTGCGTGGGCTTCTTTCTCCCTGGTACAAACGTATGGAATGCT
TCTTAAAGGGGAACTGTCAAGCTGGTGTCTTCAGCCAGATGACATGAGAGAATATCCCAGAACCCTCTCTCCAAGGTGTTTCTAGATAGC
ACAGGAGAGCAGGCACTGCACTGTCCACAGTCCACGGTACACAGTCGGGTGGGCCGCCTCCCCTCTCCTGGGAGCATTCGTCGTGCCCAG
CCTGAGCAGGGCAGCTGGACTGCTGCTGTTCAGGAGCCACCAGAGCCTTCCTCTCTTTGTACCACAGTTTCTTCTGTAAATCCAGTGTTA

>In-frame_ENST00000313806_ENST00000300305_TCGA-N5-A4RT_RCAN1_chr21_35987059_-_RUNX1_chr21_36253010_length(amino acids)=490AA_start in transcript=2_stop in transcript=1474
LPPRDSEGVNGGAAGRARTGAREAPARKPGAARWGAQGRAGAGMEDGVAGPQLGAAAEAAEAAEARARPGVTLRPFAPLSGAAEADEGGG
DWSFIDCEMEEVDLQDLPSATIACHLDPRVFVDGLCRVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRG
KSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFN
PQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTAPDLTAFSDPRQFPALPSISDPRMHYP
GAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMVGGERSPPRILPPCTNASTGSA

--------------------------------------------------------------
>In-frame_ENST00000313806_ENST00000399240_TCGA-N5-A4RT_RCAN1_chr21_35987059_-_RUNX1_chr21_36253010_length(transcript)=1632nt_BP=383nt
GCCTGCCGCCGCGCGATTCCGAGGGGGTTAACGGCGGAGCCGCCGGCCGGGCGCGGACCGGAGCGCGTGAGGCTCCGGCGCGCAAGCCCG
GAGCAGCCCGCTGGGGCGCACAGGGTCGCGCGGGCGCGGGGATGGAGGACGGCGTGGCCGGTCCCCAGCTCGGGGCCGCGGCGGAGGCGG
CGGAGGCGGCCGAGGCGCGAGCGCGGCCCGGGGTGACGCTGCGGCCCTTCGCGCCCCTCTCGGGGGCGGCCGAGGCGGACGAGGGCGGCG
GCGACTGGAGCTTCATTGACTGCGAGATGGAGGAGGTGGACCTGCAGGACCTGCCCAGCGCCACCATCGCCTGTCACCTGGACCCGCGCG
TGTTCGTGGACGGCCTGTGCCGGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACTGTGATGGCTGGCAATGATGAAAACT
ACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTCAGGTTTGTCGGTCGAAGTGGAAGAG
GGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGAGCCATCAAAATCACAGTGGATGGGC
CCCGAGAACCTCGAAATACAAGGCAGATCCAACCATCCCCACCGTGGTCCTACGATCAGTCCTACCAATACCTGGGATCCATTGCCTCTC
CTTCTGTGCACCCAGCAACGCCCATTTCACCTGGACGTGCCAGCGGCATGACAACCCTCTCTGCAGAACTTTCCAGTCGACTCTCAACGG
CACCCGACCTGACAGCGTTCAGCGACCCGCGCCAGTTCCCCGCGCTGCCCTCCATCTCCGACCCCCGCATGCACTATCCAGGCGCCTTCA
CCTACTCCCCGACGCCGGTCACCTCGGGCATCGGCATCGGCATGTCGGCCATGGGCTCGGCCACGCGCTACCACACCTACCTGCCGCCGC
CCTACCCCGGCTCGTCGCAAGCGCAGGGAGGCCCGTTCCAAGCCAGCTCGCCCTCCTACCACCTGTACTACGGCGCCTCGGCCGGCTCCT
ACCAGTTCTCCATGGTGGGCGGCGAGCGCTCGCCGCCGCGCATCCTGCCGCCCTGCACCAACGCCTCCACCGGCTCCGCGCTGCTCAACC
CCAGCCTCCCGAACCAGAGCGACGTGGTGGAGGCCGAGGGCAGCCACAGCAACTCCCCCACCAACATGGCGCCCTCCGCGCGCCTGGAGG
AGGCCGTGTGGAGGCCCTACTGAGGCGCCAGGCCTGGCCCGGCTGGGCCCCGCGGGCCGCCGCCTTCGCCTCCGGGCGCGCGGGCCTCCT
GTTCGCGACAAGCCCGCCGGGATCCCGGGCCCTGGGCCCGGCCACCGTCCTGGGGCCGAGGGCGCCCGACGGCCAGGATCTCGCTGTAGG
TCAGGCCCGCGCAGCCTCCTGCGCCCAGAAGCCCACGCCGCCGCCGTCTGCTGGCGCCCCGGCCCTCGCGGAGGTGTCCGAGGCGACGCA
CCTCGAGGGTGTCCGCCGGCCCCAGCACCCAGGGGACGCGCTGGAAAGCAAACAGGAAGATTCCCGGAGGGAAACTGTGAATGCTTCTGA

>In-frame_ENST00000313806_ENST00000399240_TCGA-N5-A4RT_RCAN1_chr21_35987059_-_RUNX1_chr21_36253010_length(amino acids)=426AA_start in transcript=2_stop in transcript=1282
LPPRDSEGVNGGAAGRARTGAREAPARKPGAARWGAQGRAGAGMEDGVAGPQLGAAAEAAEAAEARARPGVTLRPFAPLSGAAEADEGGG
DWSFIDCEMEEVDLQDLPSATIACHLDPRVFVDGLCRVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRG
KSFTLTITVFTNPPQVATYHRAIKITVDGPREPRNTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRLSTA
PDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSY

--------------------------------------------------------------
>In-frame_ENST00000313806_ENST00000486278_TCGA-N5-A4RT_RCAN1_chr21_35987059_-_RUNX1_chr21_36253010_length(transcript)=680nt_BP=383nt
GCCTGCCGCCGCGCGATTCCGAGGGGGTTAACGGCGGAGCCGCCGGCCGGGCGCGGACCGGAGCGCGTGAGGCTCCGGCGCGCAAGCCCG
GAGCAGCCCGCTGGGGCGCACAGGGTCGCGCGGGCGCGGGGATGGAGGACGGCGTGGCCGGTCCCCAGCTCGGGGCCGCGGCGGAGGCGG
CGGAGGCGGCCGAGGCGCGAGCGCGGCCCGGGGTGACGCTGCGGCCCTTCGCGCCCCTCTCGGGGGCGGCCGAGGCGGACGAGGGCGGCG
GCGACTGGAGCTTCATTGACTGCGAGATGGAGGAGGTGGACCTGCAGGACCTGCCCAGCGCCACCATCGCCTGTCACCTGGACCCGCGCG
TGTTCGTGGACGGCCTGTGCCGGGTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACTGTGATGGCTGGCAATGATGAAAACT
ACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGACCTCAGGTTTGTCGGTCGAAGTGGAAGAG
GGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACCACAGAGCCATCAAAATCACAGTGGATGGGC

>In-frame_ENST00000313806_ENST00000486278_TCGA-N5-A4RT_RCAN1_chr21_35987059_-_RUNX1_chr21_36253010_length(amino acids)=226AA_start in transcript=2_stop in transcript=679
LPPRDSEGVNGGAAGRARTGAREAPARKPGAARWGAQGRAGAGMEDGVAGPQLGAAAEAAEAAEARARPGVTLRPFAPLSGAAEADEGGG
DWSFIDCEMEEVDLQDLPSATIACHLDPRVFVDGLCRVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RCAN1-RUNX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneRUNX1chr21:35987059chr21:36253010ENST0000030030528135_143117.0481.0DNA
TgeneRUNX1chr21:35987059chr21:36253010ENST0000030030528168_177117.0481.0DNA
TgeneRUNX1chr21:35987059chr21:36253010ENST0000032507417135_143105.0469.0DNA
TgeneRUNX1chr21:35987059chr21:36253010ENST0000032507417168_177105.0469.0DNA
TgeneRUNX1chr21:35987059chr21:36253010ENST0000034469106135_14390.0454.0DNA
TgeneRUNX1chr21:35987059chr21:36253010ENST0000034469106168_17790.0454.0DNA
TgeneRUNX1chr21:35987059chr21:36253010ENST0000035835605135_14390.0251.0DNA
TgeneRUNX1chr21:35987059chr21:36253010ENST0000035835605168_17790.0251.0DNA
TgeneRUNX1chr21:35987059chr21:36253010ENST0000043718039135_143117.0481.0DNA
TgeneRUNX1chr21:35987059chr21:36253010ENST0000043718039168_177117.0481.0DNA
TgeneRUNX1chr21:35987059chr21:36253010ENST0000030030528362_402117.0481.0FOXP3
TgeneRUNX1chr21:35987059chr21:36253010ENST0000032507417362_402105.0469.0FOXP3
TgeneRUNX1chr21:35987059chr21:36253010ENST0000034469106362_40290.0454.0FOXP3
TgeneRUNX1chr21:35987059chr21:36253010ENST0000035835605362_40290.0251.0FOXP3
TgeneRUNX1chr21:35987059chr21:36253010ENST0000043718039362_402117.0481.0FOXP3
TgeneRUNX1chr21:35987059chr21:36253010ENST0000030030528291_371117.0481.0KAT6A
TgeneRUNX1chr21:35987059chr21:36253010ENST0000032507417291_371105.0469.0KAT6A
TgeneRUNX1chr21:35987059chr21:36253010ENST0000034469106291_37190.0454.0KAT6A
TgeneRUNX1chr21:35987059chr21:36253010ENST0000035835605291_37190.0251.0KAT6A
TgeneRUNX1chr21:35987059chr21:36253010ENST0000043718039291_371117.0481.0KAT6A
TgeneRUNX1chr21:35987059chr21:36253010ENST0000030030528307_400117.0481.0KAT6B
TgeneRUNX1chr21:35987059chr21:36253010ENST0000032507417307_400105.0469.0KAT6B
TgeneRUNX1chr21:35987059chr21:36253010ENST0000034469106307_40090.0454.0KAT6B
TgeneRUNX1chr21:35987059chr21:36253010ENST0000035835605307_40090.0251.0KAT6B
TgeneRUNX1chr21:35987059chr21:36253010ENST0000043718039307_400117.0481.0KAT6B


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneRUNX1chr21:35987059chr21:36253010ENST000003003052880_84117.0481.0DNA
TgeneRUNX1chr21:35987059chr21:36253010ENST000003250741780_84105.0469.0DNA
TgeneRUNX1chr21:35987059chr21:36253010ENST000003446910680_8490.0454.0DNA
TgeneRUNX1chr21:35987059chr21:36253010ENST000003583560580_8490.0251.0DNA
TgeneRUNX1chr21:35987059chr21:36253010ENST000004371803980_84117.0481.0DNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RCAN1-RUNX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RCAN1-RUNX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRCAN1C0003873Rheumatoid Arthritis1CTD_human
HgeneRCAN1C0013080Down Syndrome1CTD_human
HgeneRCAN1C0018798Congenital Heart Defects1CTD_human
HgeneRCAN1C0020179Huntington Disease1CTD_human
HgeneRCAN1C0376634Craniofacial Abnormalities1CTD_human
HgeneRCAN1C0393574Huntington Disease, Late Onset1CTD_human
HgeneRCAN1C0432416Down Syndrome, Partial Trisomy 211CTD_human
HgeneRCAN1C0432417Trisomy 21, Meiotic Nondisjunction1CTD_human
HgeneRCAN1C0751081Trisomy 21, Mitotic Nondisjunction1CTD_human
HgeneRCAN1C0751207Akinetic-Rigid Variant of Huntington Disease1CTD_human
HgeneRCAN1C0751208Juvenile Huntington Disease1CTD_human
HgeneRCAN1C2239176Liver carcinoma1CTD_human
TgeneRUNX1C1832388Platelet Disorder, Familial, with Associated Myeloid Malignancy11CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRUNX1C0023467Leukemia, Myelocytic, Acute4CGI;CTD_human;GENOMICS_ENGLAND
TgeneRUNX1C0026998Acute Myeloid Leukemia, M13CTD_human
TgeneRUNX1C1879321Acute Myeloid Leukemia (AML-M2)3CTD_human
TgeneRUNX1C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma2CTD_human
TgeneRUNX1C0003873Rheumatoid Arthritis1CTD_human
TgeneRUNX1C0006413Burkitt Lymphoma1ORPHANET
TgeneRUNX1C0017636Glioblastoma1CTD_human
TgeneRUNX1C0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
TgeneRUNX1C0023453L2 Acute Lymphoblastic Leukemia1CTD_human
TgeneRUNX1C0023473Myeloid Leukemia, Chronic1ORPHANET
TgeneRUNX1C0033578Prostatic Neoplasms1CTD_human
TgeneRUNX1C0040034Thrombocytopenia1GENOMICS_ENGLAND
TgeneRUNX1C0334588Giant Cell Glioblastoma1CTD_human
TgeneRUNX1C0349639Juvenile Myelomonocytic Leukemia1CTD_human
TgeneRUNX1C0376358Malignant neoplasm of prostate1CTD_human
TgeneRUNX1C1292769Precursor B-cell lymphoblastic leukemia1ORPHANET
TgeneRUNX1C1621958Glioblastoma Multiforme1CTD_human
TgeneRUNX1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneRUNX1C2713368Hematopoetic Myelodysplasia1CTD_human
TgeneRUNX1C3463824MYELODYSPLASTIC SYNDROME1CTD_human