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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:RCBTB1-TRIM27 (FusionGDB2 ID:72677) |
Fusion Gene Summary for RCBTB1-TRIM27 |
Fusion gene summary |
Fusion gene information | Fusion gene name: RCBTB1-TRIM27 | Fusion gene ID: 72677 | Hgene | Tgene | Gene symbol | RCBTB1 | TRIM27 | Gene ID | 55213 | 5987 |
Gene name | RCC1 and BTB domain containing protein 1 | tripartite motif containing 27 | |
Synonyms | CLLD7|CLLL7|GLP|RDEOA | RFP|RNF76 | |
Cytomap | 13q14.2 | 6p22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | RCC1 and BTB domain-containing protein 1CLL deletion region gene 7 proteinGDP/GTP exchange factor (GEF)-like proteinchronic lymphocytic leukemia deletion region gene 7 proteinregulator of chromosome condensation (RCC1) and BTB (POZ) domain containing | zinc finger protein RFPRFP transforming proteinRING finger protein 76RING-type E3 ubiquitin transferase TRIM27ret finger proteintripartite motif protein TRIM27tripartite motif-containing protein 27 | |
Modification date | 20200313 | 20200327 | |
UniProtAcc | . | P14373 | |
Ensembl transtripts involved in fusion gene | ENST00000258646, ENST00000378302, ENST00000471984, ENST00000546015, | ENST00000377194, ENST00000377199, ENST00000498117, ENST00000459807, ENST00000412687, ENST00000437160, ENST00000427689, ENST00000435528, ENST00000485666, ENST00000468364, ENST00000455861, ENST00000417660, ENST00000400720, ENST00000495323, ENST00000491158, ENST00000437415, ENST00000468047, ENST00000431123, ENST00000452265, | |
Fusion gene scores | * DoF score | 6 X 5 X 4=120 | 4 X 4 X 2=32 |
# samples | 6 | 4 | |
** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: RCBTB1 [Title/Abstract] AND TRIM27 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | RCBTB1(50134054)-TRIM27(28872442), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | RCBTB1-TRIM27 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. RCBTB1-TRIM27 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TRIM27 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10976108 |
Tgene | TRIM27 | GO:0006469 | negative regulation of protein kinase activity | 22128329 |
Tgene | TRIM27 | GO:0032897 | negative regulation of viral transcription | 18248090 |
Tgene | TRIM27 | GO:0034314 | Arp2/3 complex-mediated actin nucleation | 23452853 |
Tgene | TRIM27 | GO:0042147 | retrograde transport, endosome to Golgi | 23452853 |
Tgene | TRIM27 | GO:0045087 | innate immune response | 18248090 |
Tgene | TRIM27 | GO:0045814 | negative regulation of gene expression, epigenetic | 10976108 |
Tgene | TRIM27 | GO:0051091 | positive regulation of DNA-binding transcription factor activity | 23077300 |
Fusion gene breakpoints across RCBTB1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across TRIM27 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-CG-5721-01A | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
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Fusion Gene ORF analysis for RCBTB1-TRIM27 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000258646 | ENST00000377194 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
In-frame | ENST00000258646 | ENST00000377199 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000258646 | ENST00000498117 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000258646 | ENST00000459807 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000258646 | ENST00000412687 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000258646 | ENST00000437160 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000258646 | ENST00000427689 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000258646 | ENST00000435528 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000258646 | ENST00000485666 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000258646 | ENST00000468364 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000258646 | ENST00000455861 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000258646 | ENST00000417660 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000258646 | ENST00000400720 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000258646 | ENST00000495323 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000258646 | ENST00000491158 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000258646 | ENST00000437415 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000258646 | ENST00000468047 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000258646 | ENST00000431123 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000258646 | ENST00000452265 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
Frame-shift | ENST00000378302 | ENST00000377194 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
Frame-shift | ENST00000378302 | ENST00000377199 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000378302 | ENST00000498117 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000378302 | ENST00000459807 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000378302 | ENST00000412687 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000378302 | ENST00000437160 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000378302 | ENST00000427689 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000378302 | ENST00000435528 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000378302 | ENST00000485666 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000378302 | ENST00000468364 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000378302 | ENST00000455861 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000378302 | ENST00000417660 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000378302 | ENST00000400720 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000378302 | ENST00000495323 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000378302 | ENST00000491158 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000378302 | ENST00000437415 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000378302 | ENST00000468047 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000378302 | ENST00000431123 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000378302 | ENST00000452265 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
intron-3CDS | ENST00000471984 | ENST00000377194 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
intron-3CDS | ENST00000471984 | ENST00000377199 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
intron-intron | ENST00000471984 | ENST00000498117 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
intron-intron | ENST00000471984 | ENST00000459807 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
intron-intron | ENST00000471984 | ENST00000412687 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
intron-intron | ENST00000471984 | ENST00000437160 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
intron-intron | ENST00000471984 | ENST00000427689 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
intron-intron | ENST00000471984 | ENST00000435528 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
intron-intron | ENST00000471984 | ENST00000485666 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
intron-intron | ENST00000471984 | ENST00000468364 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
intron-intron | ENST00000471984 | ENST00000455861 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
intron-intron | ENST00000471984 | ENST00000417660 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
intron-intron | ENST00000471984 | ENST00000400720 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
intron-intron | ENST00000471984 | ENST00000495323 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
intron-intron | ENST00000471984 | ENST00000491158 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
intron-intron | ENST00000471984 | ENST00000437415 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
intron-intron | ENST00000471984 | ENST00000468047 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
intron-intron | ENST00000471984 | ENST00000431123 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
intron-intron | ENST00000471984 | ENST00000452265 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
Frame-shift | ENST00000546015 | ENST00000377194 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
Frame-shift | ENST00000546015 | ENST00000377199 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000546015 | ENST00000498117 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000546015 | ENST00000459807 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000546015 | ENST00000412687 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000546015 | ENST00000437160 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000546015 | ENST00000427689 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000546015 | ENST00000435528 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000546015 | ENST00000485666 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000546015 | ENST00000468364 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000546015 | ENST00000455861 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000546015 | ENST00000417660 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000546015 | ENST00000400720 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000546015 | ENST00000495323 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000546015 | ENST00000491158 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000546015 | ENST00000437415 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000546015 | ENST00000468047 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000546015 | ENST00000431123 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
5CDS-intron | ENST00000546015 | ENST00000452265 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000258646 | RCBTB1 | chr13 | 50134054 | - | ENST00000377199 | TRIM27 | chr6 | 28872442 | - | 2152 | 488 | 499 | 1083 | 194 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000258646 | ENST00000377199 | RCBTB1 | chr13 | 50134054 | - | TRIM27 | chr6 | 28872442 | - | 0.013166051 | 0.986834 |
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Fusion Genomic Features for RCBTB1-TRIM27 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for RCBTB1-TRIM27 |
Go to FGviewer for the breakpoints of chr13:50134054-chr6:28872442 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | TRIM27 |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. {ECO:0000269|PubMed:10976108, ECO:0000269|PubMed:12807881, ECO:0000269|PubMed:22128329, ECO:0000269|PubMed:23452853}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | RCBTB1 | chr13:50134054 | chr6:28872442 | ENST00000258646 | - | 3 | 11 | 40_91 | 148.0 | 532.0 | Repeat | Note=RCC1 1 |
Hgene | RCBTB1 | chr13:50134054 | chr6:28872442 | ENST00000258646 | - | 3 | 11 | 93_145 | 148.0 | 532.0 | Repeat | Note=RCC1 2 |
Hgene | RCBTB1 | chr13:50134054 | chr6:28872442 | ENST00000378302 | - | 5 | 13 | 40_91 | 148.0 | 532.0 | Repeat | Note=RCC1 1 |
Hgene | RCBTB1 | chr13:50134054 | chr6:28872442 | ENST00000378302 | - | 5 | 13 | 93_145 | 148.0 | 532.0 | Repeat | Note=RCC1 2 |
Hgene | RCBTB1 | chr13:50134054 | chr6:28872442 | ENST00000546015 | - | 5 | 10 | 40_91 | 148.0 | 356.0 | Repeat | Note=RCC1 1 |
Hgene | RCBTB1 | chr13:50134054 | chr6:28872442 | ENST00000546015 | - | 5 | 10 | 93_145 | 148.0 | 356.0 | Repeat | Note=RCC1 2 |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000400720 | 0 | 8 | 132_172 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000400720 | 0 | 8 | 282_311 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000412687 | 0 | 9 | 132_172 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000412687 | 0 | 9 | 282_311 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000417660 | 0 | 9 | 132_172 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000417660 | 0 | 9 | 282_311 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000427689 | 0 | 9 | 132_172 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000427689 | 0 | 9 | 282_311 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000431123 | 0 | 8 | 132_172 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000431123 | 0 | 8 | 282_311 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000435528 | 0 | 8 | 132_172 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000435528 | 0 | 8 | 282_311 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000437160 | 0 | 8 | 132_172 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000437160 | 0 | 8 | 282_311 | 0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000452265 | 0 | 9 | 132_172 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000452265 | 0 | 9 | 282_311 | 0 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000400720 | 0 | 8 | 298_492 | 0 | 514.0 | Domain | B30.2/SPRY | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000412687 | 0 | 9 | 298_492 | 0 | 359.0 | Domain | B30.2/SPRY | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000417660 | 0 | 9 | 298_492 | 0 | 359.0 | Domain | B30.2/SPRY | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000427689 | 0 | 9 | 298_492 | 0 | 359.0 | Domain | B30.2/SPRY | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000431123 | 0 | 8 | 298_492 | 0 | 514.0 | Domain | B30.2/SPRY | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000435528 | 0 | 8 | 298_492 | 0 | 514.0 | Domain | B30.2/SPRY | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000437160 | 0 | 8 | 298_492 | 0 | 514.0 | Domain | B30.2/SPRY | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000452265 | 0 | 9 | 298_492 | 0 | 359.0 | Domain | B30.2/SPRY | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000400720 | 0 | 8 | 16_57 | 0 | 514.0 | Zinc finger | RING-type | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000400720 | 0 | 8 | 96_127 | 0 | 514.0 | Zinc finger | B box-type | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000412687 | 0 | 9 | 16_57 | 0 | 359.0 | Zinc finger | RING-type | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000412687 | 0 | 9 | 96_127 | 0 | 359.0 | Zinc finger | B box-type | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000417660 | 0 | 9 | 16_57 | 0 | 359.0 | Zinc finger | RING-type | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000417660 | 0 | 9 | 96_127 | 0 | 359.0 | Zinc finger | B box-type | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000427689 | 0 | 9 | 16_57 | 0 | 359.0 | Zinc finger | RING-type | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000427689 | 0 | 9 | 96_127 | 0 | 359.0 | Zinc finger | B box-type | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000431123 | 0 | 8 | 16_57 | 0 | 514.0 | Zinc finger | RING-type | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000431123 | 0 | 8 | 96_127 | 0 | 514.0 | Zinc finger | B box-type | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000435528 | 0 | 8 | 16_57 | 0 | 514.0 | Zinc finger | RING-type | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000435528 | 0 | 8 | 96_127 | 0 | 514.0 | Zinc finger | B box-type | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000437160 | 0 | 8 | 16_57 | 0 | 514.0 | Zinc finger | RING-type | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000437160 | 0 | 8 | 96_127 | 0 | 514.0 | Zinc finger | B box-type | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000452265 | 0 | 9 | 16_57 | 0 | 359.0 | Zinc finger | RING-type | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000452265 | 0 | 9 | 96_127 | 0 | 359.0 | Zinc finger | B box-type |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | RCBTB1 | chr13:50134054 | chr6:28872442 | ENST00000258646 | - | 3 | 11 | 370_437 | 148.0 | 532.0 | Domain | BTB 1 |
Hgene | RCBTB1 | chr13:50134054 | chr6:28872442 | ENST00000258646 | - | 3 | 11 | 470_499 | 148.0 | 532.0 | Domain | BTB 2 |
Hgene | RCBTB1 | chr13:50134054 | chr6:28872442 | ENST00000378302 | - | 5 | 13 | 370_437 | 148.0 | 532.0 | Domain | BTB 1 |
Hgene | RCBTB1 | chr13:50134054 | chr6:28872442 | ENST00000378302 | - | 5 | 13 | 470_499 | 148.0 | 532.0 | Domain | BTB 2 |
Hgene | RCBTB1 | chr13:50134054 | chr6:28872442 | ENST00000546015 | - | 5 | 10 | 370_437 | 148.0 | 356.0 | Domain | BTB 1 |
Hgene | RCBTB1 | chr13:50134054 | chr6:28872442 | ENST00000546015 | - | 5 | 10 | 470_499 | 148.0 | 356.0 | Domain | BTB 2 |
Hgene | RCBTB1 | chr13:50134054 | chr6:28872442 | ENST00000258646 | - | 3 | 11 | 147_198 | 148.0 | 532.0 | Repeat | Note=RCC1 3 |
Hgene | RCBTB1 | chr13:50134054 | chr6:28872442 | ENST00000258646 | - | 3 | 11 | 199_250 | 148.0 | 532.0 | Repeat | Note=RCC1 4 |
Hgene | RCBTB1 | chr13:50134054 | chr6:28872442 | ENST00000258646 | - | 3 | 11 | 252_302 | 148.0 | 532.0 | Repeat | Note=RCC1 5 |
Hgene | RCBTB1 | chr13:50134054 | chr6:28872442 | ENST00000258646 | - | 3 | 11 | 304_356 | 148.0 | 532.0 | Repeat | Note=RCC1 6 |
Hgene | RCBTB1 | chr13:50134054 | chr6:28872442 | ENST00000378302 | - | 5 | 13 | 147_198 | 148.0 | 532.0 | Repeat | Note=RCC1 3 |
Hgene | RCBTB1 | chr13:50134054 | chr6:28872442 | ENST00000378302 | - | 5 | 13 | 199_250 | 148.0 | 532.0 | Repeat | Note=RCC1 4 |
Hgene | RCBTB1 | chr13:50134054 | chr6:28872442 | ENST00000378302 | - | 5 | 13 | 252_302 | 148.0 | 532.0 | Repeat | Note=RCC1 5 |
Hgene | RCBTB1 | chr13:50134054 | chr6:28872442 | ENST00000378302 | - | 5 | 13 | 304_356 | 148.0 | 532.0 | Repeat | Note=RCC1 6 |
Hgene | RCBTB1 | chr13:50134054 | chr6:28872442 | ENST00000546015 | - | 5 | 10 | 147_198 | 148.0 | 356.0 | Repeat | Note=RCC1 3 |
Hgene | RCBTB1 | chr13:50134054 | chr6:28872442 | ENST00000546015 | - | 5 | 10 | 199_250 | 148.0 | 356.0 | Repeat | Note=RCC1 4 |
Hgene | RCBTB1 | chr13:50134054 | chr6:28872442 | ENST00000546015 | - | 5 | 10 | 252_302 | 148.0 | 356.0 | Repeat | Note=RCC1 5 |
Hgene | RCBTB1 | chr13:50134054 | chr6:28872442 | ENST00000546015 | - | 5 | 10 | 304_356 | 148.0 | 356.0 | Repeat | Note=RCC1 6 |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000377194 | 6 | 9 | 132_172 | 315.3333333333333 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000377194 | 6 | 9 | 282_311 | 315.3333333333333 | 359.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000377199 | 6 | 8 | 132_172 | 315.3333333333333 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000377199 | 6 | 8 | 282_311 | 315.3333333333333 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000377194 | 6 | 9 | 298_492 | 315.3333333333333 | 359.0 | Domain | B30.2/SPRY | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000377199 | 6 | 8 | 298_492 | 315.3333333333333 | 514.0 | Domain | B30.2/SPRY | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000377194 | 6 | 9 | 16_57 | 315.3333333333333 | 359.0 | Zinc finger | RING-type | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000377194 | 6 | 9 | 96_127 | 315.3333333333333 | 359.0 | Zinc finger | B box-type | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000377199 | 6 | 8 | 16_57 | 315.3333333333333 | 514.0 | Zinc finger | RING-type | |
Tgene | TRIM27 | chr13:50134054 | chr6:28872442 | ENST00000377199 | 6 | 8 | 96_127 | 315.3333333333333 | 514.0 | Zinc finger | B box-type |
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Fusion Gene Sequence for RCBTB1-TRIM27 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000258646_ENST00000377199_TCGA-CG-5721-01A_RCBTB1_chr13_50134054_-_TRIM27_chr6_28872442_length(transcript)=2152nt_BP=488nt CAGAGATGTCGGCTTATTTATAGGAATTGCTTGAAGCCAGAGTCATGGTGGATGTCGGAAAGTGGCCCATCTTCACTCTACTCTCCCCTC AAGAGATCGCGTCTATTCGGAAGGCGTGTGTCTTCGGCACCTCAGCCAGTGAAGCACTGTACGTTACTGACAATGATGAGGTCTTTGTAT TTGGACTGAACTATAGTAACTGTCTAGGAACTGGAGATAACCAGAGTACACTTGTACCCAAAAAGCTAGAAGGCTTATGTGGAAAGAAGA TTAAAAGCCTCAGTTACGGGAGTGGACCACATGTTCTTCTCAGCACCGAAGATGGAGTGGTTTATGCCTGGGGCCACAATGGATATAGCC AGCTTGGGAATGGGACGACCAACCAAGGCATTGCTCCCGTCCAGGTCTGTACCAATCTCTTGATCAAGCAAGTGGTGGAAGTAGCTTGTG GCTCACATCATTCAATGGCTCTGGCAGCTGATGGAGAGTGGACGTGACTCTGGACCCAGACACGGCCTACCCCAGCCTGATCCTCTCTGA TAATCTGCGGCAAGTGCGGTACAGTTACCTCCAACAGGACCTGCCTGACAACCCCGAGAGGTTCAATCTGTTTCCCTGTGTCTTGGGCTC TCCATGCTTCATCGCCGGGAGACATTATTGGGAGGTAGAGGTGGGAGATAAAGCCAAGTGGACCATAGGTGTCTGTGAAGACTCAGTGTG CAGAAAAGGTGGAGTAACCTCAGCCCCCCAGAATGGATTCTGGGCAGTGTCTTTGTGGTATGGGAAAGAATATTGGGCTCTTACCTCCCC AATGACTGCCCTACCCCTGCGGACCCCGCTCCAGCGGGTGGGGATTTTCTTGGACTATGATGCTGGTGAGGTCTCCTTCTACAACGTGAC AGAGAGGTGTCACACCTTCACTTTCTCTCATGCTACCTTTTGTGGGCCTGTCCGGCCCTACTTCAGTCTGAGTTACTCGGGAGGGAAAAG TGCAGCTCCTCTGATCATCTGCCCCATGAGTGGGATAGATGGGTTTTCTGGCCATGTTGGGAATCATGGTCATTCCATGGAGACCTCCCC TTGAGGAGGTGAATTCAGGCCAAAAGGGCTGTTGGCTGTAATCCTACGCCAGGCACAAGGCATCTTGTTGCCTTGCCACGTCCTGTCACA GCTGGGTATCCTTACCATGTTCCACGCCCTTGCAGTGGGAGACAGGATGTCCATGTTCTCTACCATCCTTTTCCTTCCCATGCAGATTGT GAAATGTAATGAGATGTATCAAGATATCCTAGAAATAAAAACCAGATGTCCACCTCCAGTGTTTCATACTTTCTGGTTTTACACATCGCT GGAGGGATAAAGAGTATGGATAATCTTTGGATTTGGAGAGCCGTTCAAGATACTTCCAGCTTCTTGGCTCAGCCTGGCTTCCTCTGGTTC AGCCCCACATAATGATTATGGCTATTTGCTGTCATTTCTGGGCTAGGGCTCCTTTCTAACAACCTAGACTGGAATAAGGCCCTGTCAGCA TGGCTCCCTTTATCCCAGTTTTCCGTCTGGGAACAGTACCTCTGCCCCTGATTCCCAATGTGCCATAGTTTTATTAACTCCATTAAAGAA GCCTGTATGTGTTTTGGTTAGTTACAGTTATTTTACAATAATGGTGGGTAATGGCCCCACCTCTGTTATGAGATAATGTTCTAATCAATG TCTCTGCCTTTGTATCTTTTCTGAGGGCTTTGTCTGTTCTCTTCATTCTAATGAAAGGTGTATTCTAGTGCTGGGTGCATATCATCCAGG ATAATATTCTGCCCAACTCCATCCTCTGTTACTAGATCCCTTACCAGTCACATTTGTGGACTGGTGGCCAGTCGTATACCATCCCTGGAA GGATTCTGGGACAATATTCCAGGGATTCATTGACTTCTTGGCTCCTTTTCTCCATTTCCTTTGGGGGAAGGGGGAATTGACCATGCTTAA GTGCATCCTATCAAGGGGCAGCTCCGTCCCCATGGCCATTGGATCATGAGACACTCTGAAGTCAGAAGGCTGGGGCAGATCACTTCAAGC >In-frame_ENST00000258646_ENST00000377199_TCGA-CG-5721-01A_RCBTB1_chr13_50134054_-_TRIM27_chr6_28872442_length(amino acids)=194AA_start in transcript=499_stop in transcript=1083 MDPDTAYPSLILSDNLRQVRYSYLQQDLPDNPERFNLFPCVLGSPCFIAGRHYWEVEVGDKAKWTIGVCEDSVCRKGGVTSAPQNGFWAV SLWYGKEYWALTSPMTALPLRTPLQRVGIFLDYDAGEVSFYNVTERCHTFTFSHATFCGPVRPYFSLSYSGGKSAAPLIICPMSGIDGFS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for RCBTB1-TRIM27 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for RCBTB1-TRIM27 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for RCBTB1-TRIM27 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | RCBTB1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | RCBTB1 | C0154832 | Exudative retinopathy | 1 | GENOMICS_ENGLAND |
Hgene | RCBTB1 | C0339539 | Familial Exudative Vitreoretinopathy | 1 | GENOMICS_ENGLAND |
Hgene | RCBTB1 | C1867332 | Reticular Dystrophy Of Retinal Pigment Epithelium | 1 | ORPHANET |
Hgene | RCBTB1 | C4310680 | RETINAL DYSTROPHY WITH OR WITHOUT EXTRAOCULAR ANOMALIES | 1 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Tgene | TRIM27 | C0238463 | Papillary thyroid carcinoma | 2 | ORPHANET |