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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RERE-SLC2A7 (FusionGDB2 ID:73047)

Fusion Gene Summary for RERE-SLC2A7

check button Fusion gene summary
Fusion gene informationFusion gene name: RERE-SLC2A7
Fusion gene ID: 73047
HgeneTgene
Gene symbol

RERE

SLC2A7

Gene ID

473

155184

Gene namearginine-glutamic acid dipeptide repeatssolute carrier family 2 member 7
SynonymsARG|ARP|ATN1L|DNB1|NEDBEHGLUT-7|GLUT7|hGLUT7
Cytomap

1p36.23

1p36.23

Type of geneprotein-codingprotein-coding
Descriptionarginine-glutamic acid dipeptide repeats proteinarginine-glutamic acid dipeptide (RE) repeatsatrophin 2atrophin-1 like proteinatrophin-1 related proteinsolute carrier family 2, facilitated glucose transporter member 7glucose transporter type 7intestinal facilitative glucose transporter 7solute carrier family 2 (facilitated glucose transporter), member 7
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000337907, ENST00000377464, 
ENST00000400907, ENST00000400908, 
ENST00000476556, ENST00000460659, 
ENST00000400906, 
Fusion gene scores* DoF score27 X 28 X 11=83163 X 4 X 2=24
# samples 433
** MAII scorelog2(43/8316*10)=-4.27348119326891
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/24*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RERE [Title/Abstract] AND SLC2A7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRERE(8716032)-SLC2A7(9079392), # samples:3
Anticipated loss of major functional domain due to fusion event.RERE-SLC2A7 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSLC2A7

GO:0015755

fructose transmembrane transport

28083649

TgeneSLC2A7

GO:1904659

glucose transmembrane transport

28083649


check buttonFusion gene breakpoints across RERE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SLC2A7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-PG-A5BC-01AREREchr1

8716032

-SLC2A7chr1

9079392

-
ChimerDB4UCECTCGA-PG-A5BC-01AREREchr1

8716032

-SLC2A7chr1

9079392

-
ChimerDB4UCECTCGA-PG-A5BC-01AREREchr1

8716032

-SLC2A7chr1

9085133

-
ChimerDB4UCECTCGA-PG-A5BC-01AREREchr1

8716032

-SLC2A7chr1

9079392

-


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Fusion Gene ORF analysis for RERE-SLC2A7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000337907ENST00000400906REREchr1

8716032

-SLC2A7chr1

9079392

-
intron-3CDSENST00000377464ENST00000400906REREchr1

8716032

-SLC2A7chr1

9079392

-
Frame-shiftENST00000400907ENST00000400906REREchr1

8716032

-SLC2A7chr1

9079392

-
In-frameENST00000400908ENST00000400906REREchr1

8716032

-SLC2A7chr1

9079392

-
intron-3CDSENST00000476556ENST00000400906REREchr1

8716032

-SLC2A7chr1

9079392

-
intron-3CDSENST00000460659ENST00000400906REREchr1

8716032

-SLC2A7chr1

9079392

-
Frame-shiftENST00000337907ENST00000400906REREchr1

8716032

-SLC2A7chr1

9085133

-
intron-3CDSENST00000377464ENST00000400906REREchr1

8716032

-SLC2A7chr1

9085133

-
In-frameENST00000400907ENST00000400906REREchr1

8716032

-SLC2A7chr1

9085133

-
Frame-shiftENST00000400908ENST00000400906REREchr1

8716032

-SLC2A7chr1

9085133

-
intron-3CDSENST00000476556ENST00000400906REREchr1

8716032

-SLC2A7chr1

9085133

-
intron-3CDSENST00000460659ENST00000400906REREchr1

8716032

-SLC2A7chr1

9085133

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000400908REREchr18716032-ENST00000400906SLC2A7chr19079392-21819539632180405
ENST00000400907REREchr18716032-ENST00000400906SLC2A7chr19085133-18873993691886505

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000400908ENST00000400906REREchr18716032-SLC2A7chr19079392-0.0090937380.99090624
ENST00000400907ENST00000400906REREchr18716032-SLC2A7chr19085133-0.0094262470.9905737

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Fusion Genomic Features for RERE-SLC2A7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for RERE-SLC2A7


check button Go to

FGviewer for the breakpoints of chr1:8716032-chr1:9079392

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC2A7chr1:8716032chr1:9079392ENST00000400906212294_300103.66666666666667513.0RegionMonosaccharide binding
TgeneSLC2A7chr1:8716032chr1:9085133ENST00000400906012294_30017.0513.0RegionMonosaccharide binding
TgeneSLC2A7chr1:8716032chr1:9079392ENST00000400906212129_138103.66666666666667513.0Topological domainExtracellular
TgeneSLC2A7chr1:8716032chr1:9079392ENST00000400906212160_172103.66666666666667513.0Topological domainCytoplasmic
TgeneSLC2A7chr1:8716032chr1:9079392ENST00000400906212194_198103.66666666666667513.0Topological domainExtracellular
TgeneSLC2A7chr1:8716032chr1:9079392ENST00000400906212220_281103.66666666666667513.0Topological domainCytoplasmic
TgeneSLC2A7chr1:8716032chr1:9079392ENST00000400906212303_321103.66666666666667513.0Topological domainExtracellular
TgeneSLC2A7chr1:8716032chr1:9079392ENST00000400906212343_350103.66666666666667513.0Topological domainCytoplasmic
TgeneSLC2A7chr1:8716032chr1:9079392ENST00000400906212372_379103.66666666666667513.0Topological domainExtracellular
TgeneSLC2A7chr1:8716032chr1:9079392ENST00000400906212401_415103.66666666666667513.0Topological domainCytoplasmic
TgeneSLC2A7chr1:8716032chr1:9079392ENST00000400906212437_445103.66666666666667513.0Topological domainExtracellular
TgeneSLC2A7chr1:8716032chr1:9079392ENST00000400906212467_512103.66666666666667513.0Topological domainCytoplasmic
TgeneSLC2A7chr1:8716032chr1:9085133ENST00000400906012100_10717.0513.0Topological domainCytoplasmic
TgeneSLC2A7chr1:8716032chr1:9085133ENST00000400906012129_13817.0513.0Topological domainExtracellular
TgeneSLC2A7chr1:8716032chr1:9085133ENST00000400906012160_17217.0513.0Topological domainCytoplasmic
TgeneSLC2A7chr1:8716032chr1:9085133ENST00000400906012194_19817.0513.0Topological domainExtracellular
TgeneSLC2A7chr1:8716032chr1:9085133ENST00000400906012220_28117.0513.0Topological domainCytoplasmic
TgeneSLC2A7chr1:8716032chr1:9085133ENST00000400906012303_32117.0513.0Topological domainExtracellular
TgeneSLC2A7chr1:8716032chr1:9085133ENST00000400906012343_35017.0513.0Topological domainCytoplasmic
TgeneSLC2A7chr1:8716032chr1:9085133ENST00000400906012372_37917.0513.0Topological domainExtracellular
TgeneSLC2A7chr1:8716032chr1:9085133ENST00000400906012401_41517.0513.0Topological domainCytoplasmic
TgeneSLC2A7chr1:8716032chr1:9085133ENST00000400906012437_44517.0513.0Topological domainExtracellular
TgeneSLC2A7chr1:8716032chr1:9085133ENST0000040090601243_7817.0513.0Topological domainExtracellular
TgeneSLC2A7chr1:8716032chr1:9085133ENST00000400906012467_51217.0513.0Topological domainCytoplasmic
TgeneSLC2A7chr1:8716032chr1:9079392ENST00000400906212108_128103.66666666666667513.0TransmembraneHelical
TgeneSLC2A7chr1:8716032chr1:9079392ENST00000400906212139_159103.66666666666667513.0TransmembraneHelical
TgeneSLC2A7chr1:8716032chr1:9079392ENST00000400906212173_193103.66666666666667513.0TransmembraneHelical
TgeneSLC2A7chr1:8716032chr1:9079392ENST00000400906212199_219103.66666666666667513.0TransmembraneHelical
TgeneSLC2A7chr1:8716032chr1:9079392ENST00000400906212282_302103.66666666666667513.0TransmembraneHelical
TgeneSLC2A7chr1:8716032chr1:9079392ENST00000400906212322_342103.66666666666667513.0TransmembraneHelical
TgeneSLC2A7chr1:8716032chr1:9079392ENST00000400906212351_371103.66666666666667513.0TransmembraneHelical
TgeneSLC2A7chr1:8716032chr1:9079392ENST00000400906212380_400103.66666666666667513.0TransmembraneHelical
TgeneSLC2A7chr1:8716032chr1:9079392ENST00000400906212416_436103.66666666666667513.0TransmembraneHelical
TgeneSLC2A7chr1:8716032chr1:9079392ENST00000400906212446_466103.66666666666667513.0TransmembraneHelical
TgeneSLC2A7chr1:8716032chr1:9085133ENST00000400906012108_12817.0513.0TransmembraneHelical
TgeneSLC2A7chr1:8716032chr1:9085133ENST00000400906012139_15917.0513.0TransmembraneHelical
TgeneSLC2A7chr1:8716032chr1:9085133ENST00000400906012173_19317.0513.0TransmembraneHelical
TgeneSLC2A7chr1:8716032chr1:9085133ENST00000400906012199_21917.0513.0TransmembraneHelical
TgeneSLC2A7chr1:8716032chr1:9085133ENST0000040090601222_4217.0513.0TransmembraneHelical
TgeneSLC2A7chr1:8716032chr1:9085133ENST00000400906012282_30217.0513.0TransmembraneHelical
TgeneSLC2A7chr1:8716032chr1:9085133ENST00000400906012322_34217.0513.0TransmembraneHelical
TgeneSLC2A7chr1:8716032chr1:9085133ENST00000400906012351_37117.0513.0TransmembraneHelical
TgeneSLC2A7chr1:8716032chr1:9085133ENST00000400906012380_40017.0513.0TransmembraneHelical
TgeneSLC2A7chr1:8716032chr1:9085133ENST00000400906012416_43617.0513.0TransmembraneHelical
TgeneSLC2A7chr1:8716032chr1:9085133ENST00000400906012446_46617.0513.0TransmembraneHelical
TgeneSLC2A7chr1:8716032chr1:9085133ENST0000040090601279_9917.0513.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneREREchr1:8716032chr1:9079392ENST00000337907-3241156_1211108.333333333333331567.0Coiled coilOntology_term=ECO:0000255
HgeneREREchr1:8716032chr1:9079392ENST00000400908-2231156_1211108.333333333333331567.0Coiled coilOntology_term=ECO:0000255
HgeneREREchr1:8716032chr1:9079392ENST00000476556-1131156_121101013.0Coiled coilOntology_term=ECO:0000255
HgeneREREchr1:8716032chr1:9085133ENST00000337907-3241156_1211108.333333333333331567.0Coiled coilOntology_term=ECO:0000255
HgeneREREchr1:8716032chr1:9085133ENST00000400908-2231156_1211108.333333333333331567.0Coiled coilOntology_term=ECO:0000255
HgeneREREchr1:8716032chr1:9085133ENST00000476556-1131156_121101013.0Coiled coilOntology_term=ECO:0000255
HgeneREREchr1:8716032chr1:9079392ENST00000337907-3241179_1204108.333333333333331567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8716032chr1:9079392ENST00000337907-3241300_1322108.333333333333331567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8716032chr1:9079392ENST00000337907-3241425_1445108.333333333333331567.0Compositional biasNote=His-rich
HgeneREREchr1:8716032chr1:9079392ENST00000337907-3241451_1510108.333333333333331567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8716032chr1:9079392ENST00000337907-324738_1118108.333333333333331567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8716032chr1:9079392ENST00000400908-2231179_1204108.333333333333331567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8716032chr1:9079392ENST00000400908-2231300_1322108.333333333333331567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8716032chr1:9079392ENST00000400908-2231425_1445108.333333333333331567.0Compositional biasNote=His-rich
HgeneREREchr1:8716032chr1:9079392ENST00000400908-2231451_1510108.333333333333331567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8716032chr1:9079392ENST00000400908-223738_1118108.333333333333331567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8716032chr1:9079392ENST00000476556-1131179_120401013.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8716032chr1:9079392ENST00000476556-1131300_132201013.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8716032chr1:9079392ENST00000476556-1131425_144501013.0Compositional biasNote=His-rich
HgeneREREchr1:8716032chr1:9079392ENST00000476556-1131451_151001013.0Compositional biasNote=Pro-rich
HgeneREREchr1:8716032chr1:9079392ENST00000476556-113738_111801013.0Compositional biasNote=Pro-rich
HgeneREREchr1:8716032chr1:9085133ENST00000337907-3241179_1204108.333333333333331567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8716032chr1:9085133ENST00000337907-3241300_1322108.333333333333331567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8716032chr1:9085133ENST00000337907-3241425_1445108.333333333333331567.0Compositional biasNote=His-rich
HgeneREREchr1:8716032chr1:9085133ENST00000337907-3241451_1510108.333333333333331567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8716032chr1:9085133ENST00000337907-324738_1118108.333333333333331567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8716032chr1:9085133ENST00000400908-2231179_1204108.333333333333331567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8716032chr1:9085133ENST00000400908-2231300_1322108.333333333333331567.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8716032chr1:9085133ENST00000400908-2231425_1445108.333333333333331567.0Compositional biasNote=His-rich
HgeneREREchr1:8716032chr1:9085133ENST00000400908-2231451_1510108.333333333333331567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8716032chr1:9085133ENST00000400908-223738_1118108.333333333333331567.0Compositional biasNote=Pro-rich
HgeneREREchr1:8716032chr1:9085133ENST00000476556-1131179_120401013.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8716032chr1:9085133ENST00000476556-1131300_132201013.0Compositional biasNote=Arg/Glu-rich (mixed charge)
HgeneREREchr1:8716032chr1:9085133ENST00000476556-1131425_144501013.0Compositional biasNote=His-rich
HgeneREREchr1:8716032chr1:9085133ENST00000476556-1131451_151001013.0Compositional biasNote=Pro-rich
HgeneREREchr1:8716032chr1:9085133ENST00000476556-113738_111801013.0Compositional biasNote=Pro-rich
HgeneREREchr1:8716032chr1:9079392ENST00000337907-324103_283108.333333333333331567.0DomainBAH
HgeneREREchr1:8716032chr1:9079392ENST00000337907-324284_387108.333333333333331567.0DomainELM2
HgeneREREchr1:8716032chr1:9079392ENST00000337907-324391_443108.333333333333331567.0DomainSANT
HgeneREREchr1:8716032chr1:9079392ENST00000400908-223103_283108.333333333333331567.0DomainBAH
HgeneREREchr1:8716032chr1:9079392ENST00000400908-223284_387108.333333333333331567.0DomainELM2
HgeneREREchr1:8716032chr1:9079392ENST00000400908-223391_443108.333333333333331567.0DomainSANT
HgeneREREchr1:8716032chr1:9079392ENST00000476556-113103_28301013.0DomainBAH
HgeneREREchr1:8716032chr1:9079392ENST00000476556-113284_38701013.0DomainELM2
HgeneREREchr1:8716032chr1:9079392ENST00000476556-113391_44301013.0DomainSANT
HgeneREREchr1:8716032chr1:9085133ENST00000337907-324103_283108.333333333333331567.0DomainBAH
HgeneREREchr1:8716032chr1:9085133ENST00000337907-324284_387108.333333333333331567.0DomainELM2
HgeneREREchr1:8716032chr1:9085133ENST00000337907-324391_443108.333333333333331567.0DomainSANT
HgeneREREchr1:8716032chr1:9085133ENST00000400908-223103_283108.333333333333331567.0DomainBAH
HgeneREREchr1:8716032chr1:9085133ENST00000400908-223284_387108.333333333333331567.0DomainELM2
HgeneREREchr1:8716032chr1:9085133ENST00000400908-223391_443108.333333333333331567.0DomainSANT
HgeneREREchr1:8716032chr1:9085133ENST00000476556-113103_28301013.0DomainBAH
HgeneREREchr1:8716032chr1:9085133ENST00000476556-113284_38701013.0DomainELM2
HgeneREREchr1:8716032chr1:9085133ENST00000476556-113391_44301013.0DomainSANT
HgeneREREchr1:8716032chr1:9079392ENST00000337907-324507_532108.333333333333331567.0Zinc fingerNote=GATA-type
HgeneREREchr1:8716032chr1:9079392ENST00000400908-223507_532108.333333333333331567.0Zinc fingerNote=GATA-type
HgeneREREchr1:8716032chr1:9079392ENST00000476556-113507_53201013.0Zinc fingerNote=GATA-type
HgeneREREchr1:8716032chr1:9085133ENST00000337907-324507_532108.333333333333331567.0Zinc fingerNote=GATA-type
HgeneREREchr1:8716032chr1:9085133ENST00000400908-223507_532108.333333333333331567.0Zinc fingerNote=GATA-type
HgeneREREchr1:8716032chr1:9085133ENST00000476556-113507_53201013.0Zinc fingerNote=GATA-type
TgeneSLC2A7chr1:8716032chr1:9079392ENST00000400906212100_107103.66666666666667513.0Topological domainCytoplasmic
TgeneSLC2A7chr1:8716032chr1:9079392ENST000004009062121_21103.66666666666667513.0Topological domainCytoplasmic
TgeneSLC2A7chr1:8716032chr1:9079392ENST0000040090621243_78103.66666666666667513.0Topological domainExtracellular
TgeneSLC2A7chr1:8716032chr1:9085133ENST000004009060121_2117.0513.0Topological domainCytoplasmic
TgeneSLC2A7chr1:8716032chr1:9079392ENST0000040090621222_42103.66666666666667513.0TransmembraneHelical
TgeneSLC2A7chr1:8716032chr1:9079392ENST0000040090621279_99103.66666666666667513.0TransmembraneHelical


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Fusion Gene Sequence for RERE-SLC2A7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000400908_ENST00000400906_TCGA-PG-A5BC-01A_RERE_chr1_8716032_-_SLC2A7_chr1_9079392_length(transcript)=2181nt_BP=953nt
CACAGACGCTCGCGAGCAACCCTCCGCGCTCCGGAGCCTCCTCAGCCTCCCGCACACCCCGAGACGCTCGCCCCGCTGGGCCTCGGTCCC
CGCCTCCTCCCCCGTCCTTTTCCCCTCTCTCGCTCCCCACATTGTCTCTGCCTCATTTTCTCTCCTAGTTGAGGATTAAAAAAAAAAAAA
AATCACCATCATCCTCAGGGAGCCCCCTCGCCCTCGGAAAACAAAACCAGACATGATCCTGGGCTCCTGCTTCTGAAAGATCTGCCCGAC
CGAGGAGGAGGGAGCCTAGGTTCAAGTCGCAGGAAAGGTCACGGCAGGGAAGCCCCCTCAGCCCCTCCGCGTCGCCTCCCCGCGGGCCGC
CCCTCTCGGCCCTGCGCCCCGCGGCCCCGCAGCCTCCGCGCGGCCTCCCGCCCCATCCCCGCCACTTTCCCCGGAGCTGGGCCGCGAACA
CCTCACTATTGATGGTGTAGCGCTTTAGGGGAAGCATTTTTGAAACGTTGGGGTTGTTGGAGTGGTTGGATTTTCCCTGGAATTGAGTGA
GAAATTCAGAAGACTGAAGCCCAGGCTTACTGTCTACCTTTCACGGAGGCCTAGCCGTGAGAGGACAGAAGAAGGCACGTGGCGAATCAT
GACAGCGGACAAAGACAAAGACAAAGACAAAGAGAAGGACCGGGACCGAGACCGGGACCGAGAGAGAGAGAAAAGAGACAAAGCAAGAGA
GAGTGAGAATTCAAGGCCACGCCGGAGCTGTACCTTGGAAGGAGGAGCCAAAAATTATGCTGAGAGTGATCACAGTGAAGACGAGGACAA
TGACAACAATAGTGCCACCGCAGAGGAGTCCACGAAGAAGAATAAGAAGAAACCACCGAAAAAAAAGTCTCGTTATGAAAGGACAGATAC
CGGTGAGATAACATCCTACATCACTGAAGATGATGTGGTCTACAGACCAGGAGAAAGGGGACCCTGCTGATCAACAACATCTTTGCCATC
ATCCCCGCCATCCTGATGGGAGTCAGCAAAGTGGCCAAGGCTTTTGAGCTGATCGTCTTTTCCCGAGTGGTGCTGGGAGTCTGTGCAGGC
ATCTCCTACAGCGCCCTTCCCATGTACCTGGGAGAACTGGCCCCCAAGAACCTGAGAGGCATGGTGGGAACAATGACCGAGGTTTTCGTC
ATCGTTGGAGTCTTCCTAGCACAGATCTTCAGCCTCCAGGCCATCTTGGGCAACCCGGCAGGCTGGCCGGTGCTTCTGGCGCTCACAGGG
GTGCCCGCCCTGCTGCAGCTGCTGACCCTGCCCTTCTTCCCCGAAAGCCCCCGCTACTCCCTGATTCAGAAAGGAGATGAAGCCACAGCG
CGACAAGCTCTGAGGAGGCTGAGAGGCCACACGGACATGGAGGCCGAGCTGGAGGACATGCGTGCGGAGGCCCGGGCCGAGCGCGCCGAG
GGCCACCTGTCTGTGCTGCACCTCTGTGCCCTGCGGTCCCTGCGCTGGCAGCTCCTCTCCATCATCGTGCTCATGGCCGGCCAGCAGCTG
TCGGGCATCAATGCGATCAACTACTATGCGGACACCATCTACACATCTGCGGGCGTGGAGGCCGCTCACTCCCAATATGTAACGGTGGGC
TCTGGCGTCGTCAACATAGTGATGACCATCACCTCGGCTGTCCTTGTGGAGCGGCTGGGACGGCGGCACCTCCTGCTGGCCGGCTACGGC
ATCTGCGGCTCTGCCTGCCTGGTGCTGACGGTGGTGCTCCTATTCCAGAACAGGGTCCCCGAGCTGTCCTACCTCGGCATCATCTGTGTC
TTTGCCTACATCGCGGGACATTCCATTGGGCCCAGTCCTGTCCCCTCGGTGGTGAGGACCGAGATCTTCCTGCAGTCCTCCCGGCGGGCA
GCTTTCATGGTGGACGGGGCAGTGCACTGGCTCACCAACTTCATCATAGGCTTCCTGTTCCCATCCATCCAGGAGGCCATCGGTGCCTAC
AGTTTCATCATCTTTGCCGGAATCTGCCTCCTCACTGCGATTTACATCTACGTGGTTATTCCGGAGACCAAGGGCAAAACATTTGTGGAG
ATAAACCGCATTTTTGCCAAGAGAAACAGGGTGAAGCTTCCAGAGGAGAAAGAAGAAACCATTGATGCTGGGCCTCCCACAGCCTCTCCT

>In-frame_ENST00000400908_ENST00000400906_TCGA-PG-A5BC-01A_RERE_chr1_8716032_-_SLC2A7_chr1_9079392_length(amino acids)=405AA_start in transcript=963_stop in transcript=2180
MLINNIFAIIPAILMGVSKVAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVGVFLAQIFSLQAILGNPAG
WPVLLALTGVPALLQLLTLPFFPESPRYSLIQKGDEATARQALRRLRGHTDMEAELEDMRAEARAERAEGHLSVLHLCALRSLRWQLLSI
IVLMAGQQLSGINAINYYADTIYTSAGVEAAHSQYVTVGSGVVNIVMTITSAVLVERLGRRHLLLAGYGICGSACLVLTVVLLFQNRVPE
LSYLGIICVFAYIAGHSIGPSPVPSVVRTEIFLQSSRRAAFMVDGAVHWLTNFIIGFLFPSIQEAIGAYSFIIFAGICLLTAIYIYVVIP

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>In-frame_ENST00000400907_ENST00000400906_TCGA-PG-A5BC-01A_RERE_chr1_8716032_-_SLC2A7_chr1_9085133_length(transcript)=1887nt_BP=399nt
TGAAGCCCAGGCTTACTGTCTACCTTTCACGGAGGCCTAGCCGTGAGAGGACAGAAGAAGGCACGTGGCGAATCATGACAGCGGACAAAG
ACAAAGACAAAGACAAAGAGAAGGACCGGGACCGAGACCGGGACCGAGAGAGAGAGAAAAGAGACAAAGCAAGAGAGAGTGAGAATTCAA
GGCCACGCCGGAGCTGTACCTTGGAAGGAGGAGCCAAAAATTATGCTGAGAGTGATCACAGTGAAGACGAGGACAATGACAACAATAGTG
CCACCGCAGAGGAGTCCACGAAGAAGAATAAGAAGAAACCACCGAAAAAAAAGTCTCGTTATGAAAGGACAGATACCGGTGAGATAACAT
CCTACATCACTGAAGATGATGTGGTCTACAGACCAGGAGCGGCTCCAGCCGACGCTGTTGCTGGCGACACTGAGCGCGGCCTTTGGCTCA
GCCTTCCAGTACGGCTACAACCTCTCTGTGGTCAACACGCCGCACAAGGTCTTCAAGTCATTTTACAACGAAACCTACTTTGAGCGACAC
GCAACATTCATGGACGGGAAGCTCATGCTGCTTCTATGGTCTTGCACCGTCTCCATGTTTCCTCTGGGCGGCCTGTTGGGGTCATTGCTC
GTGGGCCTGCTGGTTGATAGCTGCGGCAGAAAGGGGACCCTGCTGATCAACAACATCTTTGCCATCATCCCCGCCATCCTGATGGGAGTC
AGCAAAGTGGCCAAGGCTTTTGAGCTGATCGTCTTTTCCCGAGTGGTGCTGGGAGTCTGTGCAGGCATCTCCTACAGCGCCCTTCCCATG
TACCTGGGAGAACTGGCCCCCAAGAACCTGAGAGGCATGGTGGGAACAATGACCGAGGTTTTCGTCATCGTTGGAGTCTTCCTAGCACAG
ATCTTCAGCCTCCAGGCCATCTTGGGCAACCCGGCAGGCTGGCCGGTGCTTCTGGCGCTCACAGGGGTGCCCGCCCTGCTGCAGCTGCTG
ACCCTGCCCTTCTTCCCCGAAAGCCCCCGCTACTCCCTGATTCAGAAAGGAGATGAAGCCACAGCGCGACAAGCTCTGAGGAGGCTGAGA
GGCCACACGGACATGGAGGCCGAGCTGGAGGACATGCGTGCGGAGGCCCGGGCCGAGCGCGCCGAGGGCCACCTGTCTGTGCTGCACCTC
TGTGCCCTGCGGTCCCTGCGCTGGCAGCTCCTCTCCATCATCGTGCTCATGGCCGGCCAGCAGCTGTCGGGCATCAATGCGATCAACTAC
TATGCGGACACCATCTACACATCTGCGGGCGTGGAGGCCGCTCACTCCCAATATGTAACGGTGGGCTCTGGCGTCGTCAACATAGTGATG
ACCATCACCTCGGCTGTCCTTGTGGAGCGGCTGGGACGGCGGCACCTCCTGCTGGCCGGCTACGGCATCTGCGGCTCTGCCTGCCTGGTG
CTGACGGTGGTGCTCCTATTCCAGAACAGGGTCCCCGAGCTGTCCTACCTCGGCATCATCTGTGTCTTTGCCTACATCGCGGGACATTCC
ATTGGGCCCAGTCCTGTCCCCTCGGTGGTGAGGACCGAGATCTTCCTGCAGTCCTCCCGGCGGGCAGCTTTCATGGTGGACGGGGCAGTG
CACTGGCTCACCAACTTCATCATAGGCTTCCTGTTCCCATCCATCCAGGAGGCCATCGGTGCCTACAGTTTCATCATCTTTGCCGGAATC
TGCCTCCTCACTGCGATTTACATCTACGTGGTTATTCCGGAGACCAAGGGCAAAACATTTGTGGAGATAAACCGCATTTTTGCCAAGAGA

>In-frame_ENST00000400907_ENST00000400906_TCGA-PG-A5BC-01A_RERE_chr1_8716032_-_SLC2A7_chr1_9085133_length(amino acids)=505AA_start in transcript=369_stop in transcript=1886
MKMMWSTDQERLQPTLLLATLSAAFGSAFQYGYNLSVVNTPHKVFKSFYNETYFERHATFMDGKLMLLLWSCTVSMFPLGGLLGSLLVGL
LVDSCGRKGTLLINNIFAIIPAILMGVSKVAKAFELIVFSRVVLGVCAGISYSALPMYLGELAPKNLRGMVGTMTEVFVIVGVFLAQIFS
LQAILGNPAGWPVLLALTGVPALLQLLTLPFFPESPRYSLIQKGDEATARQALRRLRGHTDMEAELEDMRAEARAERAEGHLSVLHLCAL
RSLRWQLLSIIVLMAGQQLSGINAINYYADTIYTSAGVEAAHSQYVTVGSGVVNIVMTITSAVLVERLGRRHLLLAGYGICGSACLVLTV
VLLFQNRVPELSYLGIICVFAYIAGHSIGPSPVPSVVRTEIFLQSSRRAAFMVDGAVHWLTNFIIGFLFPSIQEAIGAYSFIIFAGICLL

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Fusion Gene PPI Analysis for RERE-SLC2A7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RERE-SLC2A7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RERE-SLC2A7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneREREC4310772NEURODEVELOPMENTAL DISORDER WITH OR WITHOUT ANOMALIES OF THE BRAIN, EYE, OR HEART3CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneREREC0087031Juvenile-Onset Still Disease1CTD_human
HgeneREREC1842870Chromosome 1p36 Deletion Syndrome1ORPHANET
HgeneREREC3495559Juvenile arthritis1CTD_human
HgeneREREC3714758Juvenile psoriatic arthritis1CTD_human
HgeneREREC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneREREC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human