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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:REV3L-GTF2H5 (FusionGDB2 ID:73124) |
Fusion Gene Summary for REV3L-GTF2H5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: REV3L-GTF2H5 | Fusion gene ID: 73124 | Hgene | Tgene | Gene symbol | REV3L | GTF2H5 | Gene ID | 5980 | 404672 |
| Gene name | REV3 like, DNA directed polymerase zeta catalytic subunit | general transcription factor IIH subunit 5 | |
| Synonyms | POLZ|REV3 | C6orf175|TFB5|TFIIH|TGF2H5|TTD|TTD-A|TTD3|TTDA|bA120J8.2 | |
| Cytomap | 6q21 | 6q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA polymerase zeta catalytic subunitREV3-like, polymerase (DNA directed), zeta, catalytic subunitRev-3, yeast, homolog-like (polymerase, DNA, zeta) | general transcription factor IIH subunit 5TFB5 orthologTFIIH basal transcription factor complex TTD-A subunitTFIIH basal transcription factor complex TTDA subunitgeneral transcription factor IIH, polypeptide 5 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q6ZYL4 | |
| Ensembl transtripts involved in fusion gene | ENST00000368802, ENST00000368805, ENST00000435970, ENST00000358835, ENST00000462119, | ENST00000607778, | |
| Fusion gene scores | * DoF score | 17 X 20 X 10=3400 | 10 X 6 X 8=480 |
| # samples | 26 | 16 | |
| ** MAII score | log2(26/3400*10)=-3.70895121799661 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/480*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: REV3L [Title/Abstract] AND GTF2H5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | REV3L(111688318)-GTF2H5(158613009), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | REV3L-GTF2H5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across REV3L (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across GTF2H5 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUSC | TCGA-37-4129-01A | REV3L | chr6 | 111688318 | - | GTF2H5 | chr6 | 158613009 | + |
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Fusion Gene ORF analysis for REV3L-GTF2H5 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000368802 | ENST00000607778 | REV3L | chr6 | 111688318 | - | GTF2H5 | chr6 | 158613009 | + |
| In-frame | ENST00000368805 | ENST00000607778 | REV3L | chr6 | 111688318 | - | GTF2H5 | chr6 | 158613009 | + |
| Frame-shift | ENST00000435970 | ENST00000607778 | REV3L | chr6 | 111688318 | - | GTF2H5 | chr6 | 158613009 | + |
| In-frame | ENST00000358835 | ENST00000607778 | REV3L | chr6 | 111688318 | - | GTF2H5 | chr6 | 158613009 | + |
| intron-3CDS | ENST00000462119 | ENST00000607778 | REV3L | chr6 | 111688318 | - | GTF2H5 | chr6 | 158613009 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000368802 | REV3L | chr6 | 111688318 | - | ENST00000607778 | GTF2H5 | chr6 | 158613009 | + | 14364 | 6996 | 323 | 7009 | 2228 |
| ENST00000368805 | REV3L | chr6 | 111688318 | - | ENST00000607778 | GTF2H5 | chr6 | 158613009 | + | 14124 | 6756 | 83 | 6769 | 2228 |
| ENST00000358835 | REV3L | chr6 | 111688318 | - | ENST00000607778 | GTF2H5 | chr6 | 158613009 | + | 14496 | 7128 | 455 | 7141 | 2228 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000368802 | ENST00000607778 | REV3L | chr6 | 111688318 | - | GTF2H5 | chr6 | 158613009 | + | 0.000267602 | 0.99973243 |
| ENST00000368805 | ENST00000607778 | REV3L | chr6 | 111688318 | - | GTF2H5 | chr6 | 158613009 | + | 0.000190457 | 0.99980956 |
| ENST00000358835 | ENST00000607778 | REV3L | chr6 | 111688318 | - | GTF2H5 | chr6 | 158613009 | + | 0.000312994 | 0.9996871 |
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Fusion Genomic Features for REV3L-GTF2H5 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| REV3L | chr6 | 111688317 | - | GTF2H5 | chr6 | 158613008 | + | 1.52E-07 | 0.9999999 |
| REV3L | chr6 | 111688317 | - | GTF2H5 | chr6 | 158613008 | + | 1.52E-07 | 0.9999999 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for REV3L-GTF2H5 |
| Go to FGviewer for the breakpoints of chr6:111688318-chr6:158613009 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | GTF2H5 |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell. {ECO:0000269|PubMed:15220921}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | REV3L | chr6:111688318 | chr6:158613009 | ENST00000358835 | - | 15 | 33 | 3086_3104 | 2224.3333333333335 | 3131.0 | Motif | Note=CysB motif |
| Hgene | REV3L | chr6:111688318 | chr6:158613009 | ENST00000368802 | - | 14 | 32 | 3086_3104 | 2224.3333333333335 | 3131.0 | Motif | Note=CysB motif |
| Hgene | REV3L | chr6:111688318 | chr6:158613009 | ENST00000368805 | - | 15 | 33 | 3086_3104 | 2224.3333333333335 | 3131.0 | Motif | Note=CysB motif |
| Hgene | REV3L | chr6:111688318 | chr6:158613009 | ENST00000435970 | - | 16 | 34 | 3086_3104 | 2146.3333333333335 | 3053.0 | Motif | Note=CysB motif |
| Hgene | REV3L | chr6:111688318 | chr6:158613009 | ENST00000358835 | - | 15 | 33 | 3042_3057 | 2224.3333333333335 | 3131.0 | Zinc finger | Note=CysA-type |
| Hgene | REV3L | chr6:111688318 | chr6:158613009 | ENST00000368802 | - | 14 | 32 | 3042_3057 | 2224.3333333333335 | 3131.0 | Zinc finger | Note=CysA-type |
| Hgene | REV3L | chr6:111688318 | chr6:158613009 | ENST00000368805 | - | 15 | 33 | 3042_3057 | 2224.3333333333335 | 3131.0 | Zinc finger | Note=CysA-type |
| Hgene | REV3L | chr6:111688318 | chr6:158613009 | ENST00000435970 | - | 16 | 34 | 3042_3057 | 2146.3333333333335 | 3053.0 | Zinc finger | Note=CysA-type |
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Fusion Gene Sequence for REV3L-GTF2H5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000368802_ENST00000607778_TCGA-37-4129-01A_REV3L_chr6_111688318_-_GTF2H5_chr6_158613009_length(transcript)=14364nt_BP=6996nt CATCATCATGGCAACAAGAGCTGCAGCCTGGGACCGAGGAGCCCGTGTGATTCCCGGCGGTGGCGGCAGTGGCGGCAGCACCAGCACCGA CGAAAGCTCGAGGGCTTCTCTCCTGCGGCCCCTTGCCGGGTGCTCCTGAGGAGGCGGCGGCAGCAGCGCCTACACCGCCCCGCCCGCCGC TCCTCGAGGTGCCTCTGTGTGAGGGGAGGGGGCCGTGCCGAGAAGGGGAGGGGGCGCCGCCGCCGCTGCGGAGGGAGCCGCCGCCGCTGC TGCTGCCGCTGCCGGGTCGCCAGTGAAGGGAGGCAGTGGCGGCGGCGGCGAACATGTTTTCAGTAAGGATAGTGACTGCAGACTACTACA TGGCCAGCCCGCTGCAGGGGCTGGATACCTGCCAATCCCCCCTCACCCAGGCCCCTGTCAAGAAGGTGCCGGTGGTGCGAGTCTTCGGAG CGACCCCGGCAGGTCAGAAGACATGTCTTCATCTACATGGCATCTTTCCTTACCTCTATGTGCCATACGATGGTTATGGACAGCAGCCAG AAAGCTATCTTTCTCAGATGGCATTCAGTATCGACAGAGCACTTAATGTGGCTTTAGGCAATCCATCTTCCACTGCTCAGCATGTGTTCA AAGTGTCATTAGTATCAGGAATGCCTTTTTATGGTTATCATGAGAAGGAAAGACACTTTATGAAGATCTATCTTTACAATCCTACAATGG TGAAAAGGATATGTGAACTTTTGCAAAGCGGAGCCATAATGAATAAATTTTACCAGCCTCATGAAGCGCATATTCCCTACCTCCTACAGC TCTTCATTGACTACAATCTTTATGGCATGAATTTAATAAATCTGGCTGCTGTCAAGTTCCGAAAAGCAAGAAGGAAAAGTAATACATTGC ATGCAACTGGATCCTGCAAGAATCATTTATCAGGAAATTCTCTTGCTGATACTTTATTTCGGTGGGAACAAGATGAAATACCAAGCTCTT TAATATTGGAAGGTGTTGAACCACAGAGTACATGTGAATTAGAAGTGGATGCTGTAGCTGCTGATATCTTAAATCGTCTGGACATTGAAG CTCAAATTGGTGGAAACCCTGGTCTACAGGCCATATGGGAAGATGAAAAGCAACGGCGAAGAAACAGAAATGAAACTTCTCAAATGAGCC AACCTGAGTCACAAGATCACAGGTTTGTGCCAGCAACAGAAAGTGAAAAAAAATTTCAGAAGAGACTTCAGGAAATTCTCAAACAGAATG ATTTCTCTGTAACATTATCAGGATCTGTGGACTACAGCGATGGATCCCAGGAGTTCTCTGCTGAGTTAACATTGCACTCTGAGGTTCTGT CTCCTGAAATGCTTCAGTGTACACCAGCCAATATGGTAGAAGTTCACAAAGACAAAGAGTCAAGCAAAGGTCACACTAGACACAAAGTGG AAGAAGCTCTTATTAATGAAGAAGCAATTTTGAACCTTATGGAAAATAGTCAGACTTTTCAGCCTTTGACCCAAAGACTGAGTGAGTCAC CTGTTTTCATGGACAGTAGTCCTGATGAGGCTCTGGTACATCTTCTTGCTGGTTTGGAAAGTGATGGATATCGGGGGGAAAGAAATAGGA TGCCATCACCATGTCGCTCCTTTGGAAATAATAAATATCCACAAAATAGTGATGATGAAGAAAATGAACCACAGATTGAAAAAGAGGAAA TGGAGCTTAGTTTGGTGATGTCCCAGAGATGGGACAGCAATATTGAAGAACATTGTGCCAAAAAGAGATCACTGTGCAGAAATACCCACA GAAGTTCAACTGAAGATGATGACTCATCTTCAGGAGAAGAAATGGAATGGAGTGATAACAGTTTGCTTCTAGCCAGTCTTTCTATACCTC AGTTAGATGGAACTGCAGATGAAAATAGTGACAATCCATTGAACAATGAAAATTCTAGAACCCACTCTTCTGTAATTGCAACAAGCAAGC TTTCAGTTAAACCCTCCATCTTTCACAAAGATGCTGCTACATTAGAACCCTCATCTTCTGCTAAGATTACCTTTCAGTGTAAACACACAA GTGCCCTTTCTTCCCATGTTTTGAACAAGGAAGATTTAATTGAAGACCTTTCACAGACAAACAAAAATACAGAAAAAGGTCTAGATAACT CAGTCACTTCTTTTACAAACGAAAGCACTTATTCTATGAAATACCCTGGATCTTTAAGCAGTACTGTTCATTCAGAAAATTCTCATAAAG AGAATAGTAAGAAAGAGATCCTCCCAGTATCTTCCTGTGAAAGTAGTATTTTTGATTATGAAGAAGATATTCCATCTGTTACAAGACAAG TACCAAGTAGAAAATATACAAACATTAGAAAAATCGAAAAGGATTCCCCTTTTATACATATGCACCGTCACCCTAACGAGAATACATTGG GCAAAAATTCTTTCAACTTTTCTGACTTAAATCATTCAAAAAATAAAGTATCCTCTGAAGGAAATGAAAAAGGAAACAGCACAGCTCTGA GTAGTTTATTCCCTTCATCATTTACTGAAAATTGTGAATTACTGTCATGCTCAGGGGAGAATAGAACTATGGTGCATTCTCTTAATAGCA CTGCTGATGAAAGTGGACTAAATAAACTTAAAATTAGGTATGAAGAATTTCAAGAACATAAAACAGAAAAGCCAAGCCTCAGCCAGCAAG CAGCACACTATATGTTTTTTCCCAGTGTTGTTCTTTCTAACTGTCTTACTAGACCACAGAAACTATCTCCTGTCACATATAAATTACAAC CTGGCAATAAACCATCCCGGTTAAAATTGAATAAAAGGAAACTTGCAGGTCATCAGGAGACTTCTACCAAAAGTAGTGAGACTGGATCCA CAAAAGATAATTTTATACAAAATAATCCTTGTAATAGTAATCCTGAGAAGGATAATGCATTGGCTAGTGATTTAACTAAAACCACTCGTG GAGCTTTTGAAAATAAAACACCCACAGATGGTTTTATAGACTGTCACTTTGGAGATGGAACGTTAGAAACTGAGCAGTCCTTTGGACTAT ATGGAAATAAATACACACTTAGAGCCAAACGCAAGGTAAATTATGAGACTGAAGACAGTGAGTCAAGTTTTGTAACTCACAACTCAAAAA TTAGTCTACCTCATCCCATGGAAATTGGTGAAAGTTTAGATGGAACTCTCAAATCCCGAAAACGAAGAAAAATGTCTAAAAAGCTGCCCC CTGTCATCATAAAGTATATTATTATTAATAGATTTAGAGGGAGAAAAAATATGCTTGTGAAGCTAGGAAAAATAGACTCTAAAGAAAAAC AAGTAATATTAACAGAAGAAAAAATGGAACTATATAAAAAGCTTGCACCTTTGAAGGACTTTTGGCCAAAAGTTCCCGACTCCCCTGCAA CCAAATATCCCATTTATCCACTAACACCAAAGAAAAGTCACAGAAGAAAGTCAAAACATAAATCTGCTAAGAAAAAAACTGGTAAACAAC AAAGGACAAATAATGAAAATATTAAAAGAACTTTGTCTTTCAGGAAAAAACGGTCACATGCTATTCTTTCTCCTCCCTCACCATCTTACA ATGCTGAAACCGAAGATTGTGACCTGAATTATAGTGATGTTATGTCTAAACTAGGTTTTCTTTCTGAGAGAAGCACAAGTCCCATAAATT CTTCTCCACCTCGCTGCTGGTCTCCCACAGATCCAAGAGCTGAAGAAATCATGGCTGCTGCAGAAAAAGAGGCAATGCTTTTTAAGGGTC CTAATGTATATAAGAAGACTGTTAATTCTCGTATAGGAAAAACTAGTCGCGCAAGAGCACAGATTAAGAAATCAAAAGCAAAGCTTGCTA ATCCCTCTATAGTTACTAAGAAAAGGAACAAACGAAATCAGACAAATAAACTAGTAGATGATGGAAAAAAGAAACCAAGAGCAAAACAAA AAACAAATGAGAAAGGTACATCGAGAAAGCATACAACACTTAAGGATGAAAAAATAAAATCTCAGTCTGGTGCTGAGGTTAAGTTTGTAC TGAAACACCAGAATGTGTCTGAATTTGCAAGTAGTTCTGGAGGCTCTCAACTACTTTTTAAACAGAAAGATATGCCACTAATGGGCTCTG CTGTAGATCATCCCCTTTCTGCTTCCCTACCCACTGGAATTAATGCACAACAGAAGTTATCTGGCTGCTTTTCTTCTTTCTTAGAAAGCA AGAAGTCTGTAGATTTGCAGACATTCCCCAGTTCACGAGATGATTTGCATCCATCAGTTGTTTGTAATTCTATAGGACCTGGAGTCTCAA AAATTAATGTTCAAAGGCCTCATAATCAAAGTGCTATGTTTACTCTAAAGGAATCAACGTTAATTCAAAAAAATATATTTGACCTTTCCA ATCATTTATCTCAGGTAGCACAGAATACACAGATATCTTCTGGTATGTCCTCAAAGATAGAAGATAATGCAAATAATATACAAAGAAACT ATTTGTCATCAATCGGAAAGTTAAGTGAATATCGCAATTCCCTAGAATCAAAGCTGGACCAAGCATATACCCCTAATTTTTTGCATTGCA AAGACAGTCAGCAGCAGATTGTGTGCATAGCGGAACAGTCAAAGCACAGTGAAACTTGTTCTCCGGGAAATACAGCTTCAGAGGAAAGCC AAATGCCTAATAATTGCTTTGTAACTTCCTTGAGAAGTCCAATCAAACAAATAGCATGGGAGCAAAAGCAAAGGGGCTTTATTTTAGATA TGTCAAATTTTAAACCTGAAAGAGTAAAACCGAGGTCGTTATCAGAAGCAATTTCACAAACCAAAGCACTTTCTCAGTGTAAAAATCGAA ATGTGTCAACACCTTCAGCATTTGGTGAAGGACAGTCTGGACTGGCAGTTCTAAAAGAATTGTTACAAAAAAGACAGCAGAAAGCACAAA ATGCAAATACTACACAAGACCCATTATCCAATAAACATCAACCAAATAAAAATATTTCTGGTTCCCTTGAGCATAACAAAGCAAATAAAC GGACACGATCGGTAACGTCCCCAAGAAAACCTCGAACTCCCAGAAGTACAAAACAAAAAGAAAAAATCCCCAAACTTCTCAAAGTAGACT CTTTAAATTTACAAAACTCTAGCCAGTTGGATAACTCTGTATCAGATGATAGTCCCATCTTTTTTTCAGATCCAGGCTTTGAAAGTTGTT ACTCACTTGAAGATAGTTTATCTCCTGAACATAATTATAATTTTGATATTAACACAATAGGTCAGACTGGATTTTGTAGCTTTTATTCTG GAAGTCAGTTTGTCCCAGCTGATCAGAATTTGCCTCAGAAGTTCCTAAGTGATGCTGTTCAGGATCTTTTTCCAGGACAAGCTATAGAAA AAAATGAGTTTTTAAGTCATGACAACCAGAAATGTGATGAAGACAAGCATCATACCACAGACTCAGCCTCATGGATTAGATCTGGTACTT TAAGTCCTGAAATTTTTGAGAAGTCAACCATAGATAGCAATGAGAATCGTCGCCACAACCAGTGGAAAAATAGCTTTCATCCTCTAACAA CTCGGTCTAACTCAATAATGGATTCTTTCTGTGTTCAGCAGGCAGAAGACTGTCTAAGTGAAAAATCTAGATTGAATAGGAGTTCAGTAA GCAAAGAAGTGTTTCTTAGCCTCCCACAGCCAAACAATTCAGACTGGATTCAAGGTCACACCAGAAAAGAAATGGGACAGTCTCTTGACT CAGCCAATACCTCTTTTACTGCAATACTCTCCTCCCCTGATGGTGAACTTGTAGACGTGGCCTGTGAAGATTTAGAACTGTATGTTTCAA GAAACAATGATATGTTGACACCAACTCCTGATAGTTCACCAAGATCTACTAGCTCTCCTTCACAATCTAAAAATGGCAGCTTCACCCCTC GAACTGCTAACATTCTGAAACCACTTATGTCCCCCCCAAGTAGGGAAGAAATTATGGCAACTTTGTTGGATCATGACCTGTCTGAGACTA TTTACCAGGAACCATTTTGCAGTAATCCTTCTGATGTACCAGAAAAGCCCAGGGAGATTGGTGGACGGCTCCTCATGGTAGAAACTCGAC TTGCAAATGATCTGGCTGAGTTTGAGGGAGACTTTTCCTTGGAAGGACTTCGTCTTTGGAAAACAGCATTCTCAGCAATGACTCAGAATC CAAGGCCAGGGTCACCCCTTCGCAGTGGCCAAGGAGTTGTCAATAAAGGGTCAAGTAATAGCCCTAAGATGGTTGAAGATAAAAAAATTG TGATTATGCCTTGCAAATGTGCCCCAAGTCGACAACTGGTTCAAGTGTGGCTTCAAGCCAAAGAAGAATACGAACGTTCCAAGAAACTGC CTAAAACCAAGCCAACTGGAGTTGTAAAATCTGCTGAGAACTTTAGCTCTTCAGTTAACCCAGATGACAAACCTGTAGTGCCTCCAAAAA TGGATGTAAGTCCATGTATACTCCCCACTACAGCACATACCAAGGAGGATGTTGATAATTCTCAGATTGCTTTACAAGCACCAACCACGG GATGTAGTCAAACTGCAAGTGAAAGTCAGATGCTGCCACCAGTTGCCTCTGCAAGTGATCCCGAAAAAGATGAAGATGATGATGATAACT ATTACATTAGTTATAGCTCCCCTGATTCTCCAGTAATTCCCCCTTGGCAACAACCAATATCCCCAGATTCCAAAGCATTAAATGGAGATG ATAGACCCTCATCACCAGTAGAGGAGCTGCCTTCATTGGCTTTTGAGAACTTCTTAAAGCCAATAAAAGATGGTATACAAAAAAGCCCCT GCAGTGAGCCTCAAGAGCCTCTAGTGATATCTCCAATTAATACTAGGGCAAGAACTGGGAAATGTGAATCACTTTGCTTTCATAGTACAC CAATCATACAGAGAAAACTTCTGGAAAGGCTTCCTGAAGCACCTGGCCTTAGCCCATTATCAACAGTGATCCTGCCATGAAGCAGTTTCT GCTGTACTTGGATGAGTCCAATGCCCTGGGGAAGAAGTTCATCATTCAAGACATTGATGACACTCACGTCTTTGTAATAGCAGAATTGGT TAATGTCCTCCAGGAGCGAGTGGGTGAATTAATGGACCAAAATGCTTTTTCCCTTACCCAGAAATGAAAATACTCAATATGGACCATTTA GGAATTATAAGCAGCAACTGTGAAAGACTTGCCACTCAATATCTTAGGTGACTGATTAGACATAGAGGGTTGTTTTAGGAGCATGCCACG GGAAAGACTGAGGGATCATGATCATTTGTTCAGAAAAAAAGCCCCTGAACTGATTTTGTTACCATAGAATTTAAAAAAAAAAAAAGCTTT AACAGTTGGCTGTAATTTGGCTTTTATTATCCTTTATTAAAATACAAATGTCAATGCTTTTCCTGCCTTTTTAATACCATGTCAGTGTAA CATAGGTATTTATTTTGCTCATCCCTGTGATCTGTGCATTTTTGCTGCGTGGATGTGATTGTTTGGTTTCAGTTAGAAACGTCATAGATT TGCTGTTTGAATATGCCAAGGTGGGGACTTAGACATTATGTACGTCTCACAAATCCTACCTGCATACCAGTCAGCTCTATTGAGGAAGAC AATGTAAAACTAATGTAAACTACAGTTTGCATTTCCCTGAAAACAGAATATTGTTTTTAAGAGGGTTAGAAACAACCAGTGGGAAAGGCA CATGCTGCTTTGTTTAGTTTTTCCTTGTTCAAACTTTGTTGGTCACATTTTCCCATCTGTATTCTTTTTTATTAAGAAAACAGCTTAGGG AGGCTGAGGTGGGAGGATTGCTTGAGCCCAGGAGTCCGAGGTTGCTACAAAAACACCATTGCACTCTGGCCTGGACAACAGAGAGACCCT GCCTCAAAAAAAAAAAAAAAAAAAAAAAAAATTCTACTTGTACCTTATTCCCTATGAGAATACTTATCAAACTTATCTAAAAAAGAAAAA TAGGAACAGCCATATGCAAAGTCAGCCCAACAGGAAAGGACATATTAGATTAAAATACATTGCGGCCTGGGCTTAGTGGCTCACACCTGT AATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATCGCTTGAGTCCAGGAGTCGAAACCCTGTCTCTACAAAAAAAAAAATACAAAAATC TGCCTGTTGTCCCAGCCACTGGGGAGGCTGAGGTAGGAGGTCAAGGCTGCAGTGAACCTTGATCATTGCTACTGCCACTCCAGCCTAGGT GACAGAGTGAGACCCTGTCTCCAAAAAAAAAAGTGTATATGTATGTGTGTATATATAGCAAGAGAGAGTTCTGTGATCAATTGAAGGCAA AAACAGTAACACTGAGAGGGGCTTTGCTTCCCTTCCTGAAGATCATGTCATTGGGGTGGGTTCCTGTAAAGGGAATTTTCCAAGAGAAAA GAGAATTTTCATGACCTGTAGACTCTTACAAATCCATTTTACCTGCTTCCTTATGGTATGTTTATTCAAAGCACCTGTGTACCATATTTA TTCACTTACACAGCATTACTGAATCTGGAAATTTTCAGTTAGGTATATTTTACATAATTCCCACCCATATAACTCAGTCCATACAGTTCA CAGTTTTCATTCCCTCATAGCAATGCAAAAAATTTTGATGAGTTACTACTACTAAAACTAGTTAAGTAAAAGATGATTCTTAAGAATTTC CAGGCTGGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGCTCACGAGGTCAGGAGATCGAGACCATCC TGCTCGGTGAAACCCCATCTCTATTAAAAATACAAAAAATTAGCCGGGCCTGGTGGCGGGTGCCTGTAGTCCCATCTACTCAGGAGGCTG AGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTAAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGCGACAGAGGGAGAC TCCATCTCAAAAAAAAAAAAAAAAAAAAATGAATTTCCAGCTATACCAAAATGTTACTAATGTATCTTATATTTCAGGCATGTCTAAATC AACTTTTAGTATGCCTCAGGCATTTGTCACCAACCTTTTATATTAACATGAAACTTAGAAAATTTTTGATAGAATCCCAGAGTTCAAAAG GTATTAGGATTTTTGCCACTGAAGTAAAAAAGAGAAAAAAAGATATTTATGAGAAAACTATTGAACAGTGACTGTGTTGTACCCGAGCAA GTTAGAGGAACGCCACACTTTGAGACGAATTTAAAAGTCCTTTATTTAGCTGGCAGCCAAGAGGTGGCTCACACTTGGAATTCTCTCAGC TCCGAGGAAGGGGCTTGATTTTCCTTTATACTTTGGTTTAGGAAGGGGACGGGAGCTCAGTTGCAACAATTCTACAGAAGTAAAAACATG CAAAAAATTAAAAAGACAAATGGTTACAGAGAAACAAACAGTTCCAGGTGCAGGGGCTCTAAATCTATCATAAGATGTCAGGTGTGGGGG CTCTGCCAGACACAAACTCAAGGCTTTATGGTGTATCTCTTGAGCGAAATCCTGGGAACTTCGTACATTGCTTGCTTCAGTACCTTATGA GTTAATTGGACTCTTTGATATGTTGAGAGTCAGCTTACACAAGTTAACTCCTTGAGGAAAGGGGGTGGGTAAGGAGTCCTTGATGTCCTG TAAATGAAGGAACCAAATGGAGTTCCTCCGGCTTTCTCAGCTAAGGGAGAGCTTATTCACATGGAAACAAGGCTAGGTGATTAAGGGAGA AAGGGACAGTCTGAAAACAAGGTTAGTAAAAACAAGGTTAGGTATTAGAACTGCAAAGAGTATTAAGTGAAATAAGTGAAGGAAAATATG AGCTCTTATTTTTAAAAAGTTGTGTTGGGGCAAATGTTAAATATCTTTCTTTCTCTGGACATTATTAAGAAAGATAGAGTGATGTGAATG ATAGGAAGCCCACCTGTAACCACTTAGCTGACATGTCCAACTATGGGTGAACAGGAAATAAGCGACATTCACCTAGGCTGTTTATTGGAA TCTGACTAGCATTATTTGATTTGGCATACTTTACATGTCCAGAACAAGGCTGTTGGTGCTTGGCACCAAGAAATTTATGACTTTTTTTTT TTTTTTAAATAAAGTCCTAAAGGTAGCATTAAAATGACTTAACTGGAGGCAGGAGGATCACTGAAGCCCAGGAGTTTGAAGCTGCAGTAA GCTAAGAAGGTGCCACTGCACTGCAGCCTGGATGACAGAGTGAAACTTTGTCTCTTAATAGAACTATGGACTGAAGTTGTGATATTGAGT GTTATATTTCTCAATAAAGGTTTTTTCTTTTAATACTGTATTAGGTCAAATTCAAGGTCTTAATTCCTTGAATTCCAATTTCCTTGTGAA ATTTCATGTGATTAATTTAAAATTCCAGGGATCCTATCTAACATCACAGTTGATGGATATAACAATGTATTTTGAGAAATCAGTTTTGGT GAACAGTAACAGCATTACTGATAATAGGCAACAAACACTACTGCATTTTATTTCTGATAGGCATTATAGGTGGTAATCCAAATGATTAAT GATTTTATTGCTCTTTACATTTTCTAGAACAGGTGATTTGACATAATTGTACTTTTTTCTGAGAAGTTGGTAGTGTACTTACTACTCTAT TTTGCAGTTATACAATAAATCTTACTTAGCTGACAACTAGGAGTAAAAGCTCTGACAAAAAGCCTCTGCTGTAACTAAAATACTGAGATC ATTCTATCTTAACAAACTTAACAGATGGGGAAGGGGTATATTTTAAAGATGGAGAAATGATGCAGTTTGCAAATATAGTCAATAAATATT CTCAAGTGTACGTAGCTCAATTTCATTTGCAGCAAAGATAACACTGAAATGTCTATGGATGAGATTATTGGATAAACTTTTTTAAAAACA CTGTTCTCAAGATAGGCAAGTGATTAAGAGCACTGACTGGGCCGGGCGCGGTGGCTCACGTCTATAATCCTAGCACTTTGGGAGGCCGAG GCGGGCAAATCACAAGGTCAGGAGATCAAAACAATCCTGGCTAACAAGGTGAAACCCCGTCTCTACTAAAAATACAAAAAAATTAGCTGG GCATGGTGGTGGACGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGTGTAATCCCGGGAGGTGGAGGTTGCAGTGAGCC GAGATCGTGCCACTGCACTCCAGCCGGGGTGACAGAGCGAGACTCCCACCCATCTCAAAAAAAATAAAAATGAAAAGCACTGATTGAATC TAGATTCCTTGAGTCCAAGTGTCAGATCTCTGCTTACTAGCTCTGGGATCTCAGATGTTTCGTTGATTGGATTTCTTTGTGCTCATTTGT GTAAACAGGAATGCCCGTCTTTAAAGACTATTAAAATGAATGTGAGTTAACACACAAGAGGTCTTCAAAAAGTTGATGGAAAATGCATAT TATGAAAAAAATTATGCATAGATTTCAAAAATCTTTGCAGCAAAATAAACTCATCATTATAACATGTCTGAACAGGATCTAGTTTGAGGC ACTAAGAAGGATATCAGTTTAAATAGAGCCCCTGTCAGAACAATATGAATTCTGCTAAAACTGAAGCAAGAACAAACATCAAATTTATGG CAAAGCTTAGGTGGAAGAATGGTGCAATCATTGATGCTTTGCAAAAAGTTTATGGGAACAACGCCCCAAGGAAATCAGTTTACAAATGGA TAATTCATTTTAAGAAAGGACAAGACAATGTTGAAGATGAAACCTACAGCAGCAGACCATGCCACTTCGTGAGGAAAAAATTATCTCATT CATGCCCTACTTGAAGAGGACCAATGATTAACAGCAGAAACGATAGCCAACACAATATGCTCCTCAGTTGGTTCAGCTTTTATAAATCTG ACTGAAAAATTAAAGTTGAGCACACTTTCCACTCAATGGATACCAAAACCATCCAGCCCAGGTCAGCTGCAGACAAAAGCAGAGCTTTCG ATGGAAATGTCAAACAAGTGAGATCAAGATCCTGAAGCATTTCTTCAAAGAATTGTAGCAAAAACAGACTTTTAAAACCTTGAATTCAGA GACAGGTATAAAGACTGCTTGGTGATTTTGAAAGGACTGAGATCATTTTGGGAGAGATCATCTTCAGAAAATGACCAGATACAACAAGAA TTTAACATGGCAGCCAAACCAACCCACTAACACACATTTAAATAAGATACCCAAATGCAGAAAGAAAAGCACAGTCGTCATGCAAAATAG TCACTACTCATTCAAAAACTCTATAGTTGTCTGAGTCGTTATGCTCAAAATATCCAATAATATTTCTTTTGCTGAGCTGTAAAATAATTA TTTTGCAAACATAAAAGAAAAAAAAAAGAATTGTAACAGAAACATGGCTTTACCAGTATGACCCTCAAGACAAAATACAAAACAATGGCT ACCAAGAGGTGGAAGTGGCCCAGTCACAGCAAGAGCAGATTGATCAAGAGCAAAGGTCATGGTAACAGTTTTTTGGATCCTCAAGTCATT TTGCTTGTTGACTTTTTGGAGGGCCAAATAAAGATATCATCTGCTTATTATGAGAGTGTTTCGAGAGAAATCCAAAGCTTAGCAGAGAAA CGCCTGGGAAAGCTTCACCAGAGGGTCTTCCACCGTGACAGTTCCCCTGCGCATTCCTCTCATAAAGCAAGGGCAGTTTAGCTAGAATTT CTATCAAAAATCATTAGGTATCCATCTCCCAGTCCTGATTTGGCTCCTTCTGACTTCTTTTTGTTTCCCAATCTTAAAAAAATCCCTGAA GGGCACCTGTTTTTCTTCAGCTAATAAAAAAGACATGGTTAATTTCCCAGGACCCTCAGTTCTTTAGGGATAGACTGAATGGCTGGTATC ATTGCTTGAACTTAATGGAGCTTATGTTGAGAAATAAAAGAAATTATATTTTATTTTTATCTTTTAATTCTATTTTTCCATGAACTTTTT GAAGTCCCCTCAGATATAAAGCAGAACGTTATGAAACTGAGTTACCTTGAATCTAGAAGAGTACAATGATAAAGGGGAAGATAGAAACAC ACACATATGCGTTGTTTTCCCCACTTTCACAATGCCGTGCAGAAACTAACAGATGAAGGAGGAGAATCCCTAAAAACAGAGCATTGGGTA GCTAGTCCACCAGCGGTCTGATGCTTTCATTGATCTCAAAACTGTCTCTGAGTAACTCTACCAGGAAAGTTGTCTGGAGGGTTAACATTT CTGAAACCATTTTTATCTTTGCCTTCATTCTTGAATGATAATTAGTCTCGAATGTTTGGATCACAATCCATTGAAAGACTAGGCTATTTT TTCACTGTCCTCAGACATTTACTGAGTCCAGTTTGGACTTTATTTTATTTTATTTTTTTTGAAACAAGATCTCGCTCTGTTGCTCAGGCT GAAGTGCAATAGCGCAAACTCGGCTCACTGCAACCTCCCAGGTTCAAGCAATTCTCGTGCCTCAGCCATCCCTATAGGCATGCGCCACCA CACTTTGCTAATCTTGTATTTTTGGTAGAGACGGGGTTTGCACCATGTTGGCCAGGCTGGTCTCGAACTCCCAACCTCAAGTAATCTGGC CTCCCAAAGTGGTGGGATTACAGGCGTGAGCCAGCGCGCCCGGCCTGGACTTAACTTCTGAAGAACTCTTTCTGTTTAGATTGCAGGAGC GTTCTCTCGGCTCATCTCTTGTTTTCTCACCCAGCTGTTCTTCTTCTAGTTGGCCATCATTCTTCATCCCTCCCTCCCTTTCCTGCAGTT AATTATTTCTTTGAAATTTTAAAACTTCTTAATGTTGCCTGGAATACATGAGTCTTCCTGATCTCTTCAAACGGGGTTTGTTTTGTTTTG CTTTGGGGAGAATTCTTTTGACGTTTTTGAATAAGCTGTTAACAACTTTAATACCTGTCTTGTTTGTTTTCTTCAGAAATTTGTTAATTC TCCATGATTAGCACCTTTATGTGGTTATCTCATTATTTTCATTCCTTTTTAATTCTCTGTTTTAGGAATGCTTGTCAAATTCGTCACTAA AATTGATTTACTTTCTTGAAAACCTGTTTCTGCTGCTCCCAACATGATTTAATCTTGGCTACTGAGCTTTTGGTTACGTTGCACTCCCTT TAAAATTACTCCGTTTAAGTACAGTGTTCACTCTTTGGGTAATGTGTACAATAGAAGCCCAATCCCCACCTATACCCAATATATCCATGG >In-frame_ENST00000368802_ENST00000607778_TCGA-37-4129-01A_REV3L_chr6_111688318_-_GTF2H5_chr6_158613009_length(amino acids)=2228AA_start in transcript=323_stop in transcript=7009 MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAGQKTCLHLHGIFPYLYVPYDGYGQQPESYLSQMAFSIDRALNVA LGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYNPTMVKRICELLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAV KFRKARRKSNTLHATGSCKNHLSGNSLADTLFRWEQDEIPSSLILEGVEPQSTCELEVDAVAADILNRLDIEAQIGGNPGLQAIWEDEKQ RRRNRNETSQMSQPESQDHRFVPATESEKKFQKRLQEILKQNDFSVTLSGSVDYSDGSQEFSAELTLHSEVLSPEMLQCTPANMVEVHKD KESSKGHTRHKVEEALINEEAILNLMENSQTFQPLTQRLSESPVFMDSSPDEALVHLLAGLESDGYRGERNRMPSPCRSFGNNKYPQNSD DEENEPQIEKEEMELSLVMSQRWDSNIEEHCAKKRSLCRNTHRSSTEDDDSSSGEEMEWSDNSLLLASLSIPQLDGTADENSDNPLNNEN SRTHSSVIATSKLSVKPSIFHKDAATLEPSSSAKITFQCKHTSALSSHVLNKEDLIEDLSQTNKNTEKGLDNSVTSFTNESTYSMKYPGS LSSTVHSENSHKENSKKEILPVSSCESSIFDYEEDIPSVTRQVPSRKYTNIRKIEKDSPFIHMHRHPNENTLGKNSFNFSDLNHSKNKVS SEGNEKGNSTALSSLFPSSFTENCELLSCSGENRTMVHSLNSTADESGLNKLKIRYEEFQEHKTEKPSLSQQAAHYMFFPSVVLSNCLTR PQKLSPVTYKLQPGNKPSRLKLNKRKLAGHQETSTKSSETGSTKDNFIQNNPCNSNPEKDNALASDLTKTTRGAFENKTPTDGFIDCHFG DGTLETEQSFGLYGNKYTLRAKRKVNYETEDSESSFVTHNSKISLPHPMEIGESLDGTLKSRKRRKMSKKLPPVIIKYIIINRFRGRKNM LVKLGKIDSKEKQVILTEEKMELYKKLAPLKDFWPKVPDSPATKYPIYPLTPKKSHRRKSKHKSAKKKTGKQQRTNNENIKRTLSFRKKR SHAILSPPSPSYNAETEDCDLNYSDVMSKLGFLSERSTSPINSSPPRCWSPTDPRAEEIMAAAEKEAMLFKGPNVYKKTVNSRIGKTSRA RAQIKKSKAKLANPSIVTKKRNKRNQTNKLVDDGKKKPRAKQKTNEKGTSRKHTTLKDEKIKSQSGAEVKFVLKHQNVSEFASSSGGSQL LFKQKDMPLMGSAVDHPLSASLPTGINAQQKLSGCFSSFLESKKSVDLQTFPSSRDDLHPSVVCNSIGPGVSKINVQRPHNQSAMFTLKE STLIQKNIFDLSNHLSQVAQNTQISSGMSSKIEDNANNIQRNYLSSIGKLSEYRNSLESKLDQAYTPNFLHCKDSQQQIVCIAEQSKHSE TCSPGNTASEESQMPNNCFVTSLRSPIKQIAWEQKQRGFILDMSNFKPERVKPRSLSEAISQTKALSQCKNRNVSTPSAFGEGQSGLAVL KELLQKRQQKAQNANTTQDPLSNKHQPNKNISGSLEHNKANKRTRSVTSPRKPRTPRSTKQKEKIPKLLKVDSLNLQNSSQLDNSVSDDS PIFFSDPGFESCYSLEDSLSPEHNYNFDINTIGQTGFCSFYSGSQFVPADQNLPQKFLSDAVQDLFPGQAIEKNEFLSHDNQKCDEDKHH TTDSASWIRSGTLSPEIFEKSTIDSNENRRHNQWKNSFHPLTTRSNSIMDSFCVQQAEDCLSEKSRLNRSSVSKEVFLSLPQPNNSDWIQ GHTRKEMGQSLDSANTSFTAILSSPDGELVDVACEDLELYVSRNNDMLTPTPDSSPRSTSSPSQSKNGSFTPRTANILKPLMSPPSREEI MATLLDHDLSETIYQEPFCSNPSDVPEKPREIGGRLLMVETRLANDLAEFEGDFSLEGLRLWKTAFSAMTQNPRPGSPLRSGQGVVNKGS SNSPKMVEDKKIVIMPCKCAPSRQLVQVWLQAKEEYERSKKLPKTKPTGVVKSAENFSSSVNPDDKPVVPPKMDVSPCILPTTAHTKEDV DNSQIALQAPTTGCSQTASESQMLPPVASASDPEKDEDDDDNYYISYSSPDSPVIPPWQQPISPDSKALNGDDRPSSPVEELPSLAFENF -------------------------------------------------------------- >In-frame_ENST00000368805_ENST00000607778_TCGA-37-4129-01A_REV3L_chr6_111688318_-_GTF2H5_chr6_158613009_length(transcript)=14124nt_BP=6756nt TGGTTGCGTCCGTGACATCATCATCATGGCAACAAGAGCTGCCGGGTCGCCAGTGAAGGGAGGCAGTGGCGGCGGCGGCGAACATGTTTT CAGTAAGGATAGTGACTGCAGACTACTACATGGCCAGCCCGCTGCAGGGGCTGGATACCTGCCAATCCCCCCTCACCCAGGCCCCTGTCA AGAAGGTGCCGGTGGTGCGAGTCTTCGGAGCGACCCCGGCAGGTCAGAAGACATGTCTTCATCTACATGGCATCTTTCCTTACCTCTATG TGCCATACGATGGTTATGGACAGCAGCCAGAAAGCTATCTTTCTCAGATGGCATTCAGTATCGACAGAGCACTTAATGTGGCTTTAGGCA ATCCATCTTCCACTGCTCAGCATGTGTTCAAAGTGTCATTAGTATCAGGAATGCCTTTTTATGGTTATCATGAGAAGGAAAGACACTTTA TGAAGATCTATCTTTACAATCCTACAATGGTGAAAAGGATATGTGAACTTTTGCAAAGCGGAGCCATAATGAATAAATTTTACCAGCCTC ATGAAGCGCATATTCCCTACCTCCTACAGCTCTTCATTGACTACAATCTTTATGGCATGAATTTAATAAATCTGGCTGCTGTCAAGTTCC GAAAAGCAAGAAGGAAAAGTAATACATTGCATGCAACTGGATCCTGCAAGAATCATTTATCAGGAAATTCTCTTGCTGATACTTTATTTC GGTGGGAACAAGATGAAATACCAAGCTCTTTAATATTGGAAGGTGTTGAACCACAGAGTACATGTGAATTAGAAGTGGATGCTGTAGCTG CTGATATCTTAAATCGTCTGGACATTGAAGCTCAAATTGGTGGAAACCCTGGTCTACAGGCCATATGGGAAGATGAAAAGCAACGGCGAA GAAACAGAAATGAAACTTCTCAAATGAGCCAACCTGAGTCACAAGATCACAGGTTTGTGCCAGCAACAGAAAGTGAAAAAAAATTTCAGA AGAGACTTCAGGAAATTCTCAAACAGAATGATTTCTCTGTAACATTATCAGGATCTGTGGACTACAGCGATGGATCCCAGGAGTTCTCTG CTGAGTTAACATTGCACTCTGAGGTTCTGTCTCCTGAAATGCTTCAGTGTACACCAGCCAATATGGTAGAAGTTCACAAAGACAAAGAGT CAAGCAAAGGTCACACTAGACACAAAGTGGAAGAAGCTCTTATTAATGAAGAAGCAATTTTGAACCTTATGGAAAATAGTCAGACTTTTC AGCCTTTGACCCAAAGACTGAGTGAGTCACCTGTTTTCATGGACAGTAGTCCTGATGAGGCTCTGGTACATCTTCTTGCTGGTTTGGAAA GTGATGGATATCGGGGGGAAAGAAATAGGATGCCATCACCATGTCGCTCCTTTGGAAATAATAAATATCCACAAAATAGTGATGATGAAG AAAATGAACCACAGATTGAAAAAGAGGAAATGGAGCTTAGTTTGGTGATGTCCCAGAGATGGGACAGCAATATTGAAGAACATTGTGCCA AAAAGAGATCACTGTGCAGAAATACCCACAGAAGTTCAACTGAAGATGATGACTCATCTTCAGGAGAAGAAATGGAATGGAGTGATAACA GTTTGCTTCTAGCCAGTCTTTCTATACCTCAGTTAGATGGAACTGCAGATGAAAATAGTGACAATCCATTGAACAATGAAAATTCTAGAA CCCACTCTTCTGTAATTGCAACAAGCAAGCTTTCAGTTAAACCCTCCATCTTTCACAAAGATGCTGCTACATTAGAACCCTCATCTTCTG CTAAGATTACCTTTCAGTGTAAACACACAAGTGCCCTTTCTTCCCATGTTTTGAACAAGGAAGATTTAATTGAAGACCTTTCACAGACAA ACAAAAATACAGAAAAAGGTCTAGATAACTCAGTCACTTCTTTTACAAACGAAAGCACTTATTCTATGAAATACCCTGGATCTTTAAGCA GTACTGTTCATTCAGAAAATTCTCATAAAGAGAATAGTAAGAAAGAGATCCTCCCAGTATCTTCCTGTGAAAGTAGTATTTTTGATTATG AAGAAGATATTCCATCTGTTACAAGACAAGTACCAAGTAGAAAATATACAAACATTAGAAAAATCGAAAAGGATTCCCCTTTTATACATA TGCACCGTCACCCTAACGAGAATACATTGGGCAAAAATTCTTTCAACTTTTCTGACTTAAATCATTCAAAAAATAAAGTATCCTCTGAAG GAAATGAAAAAGGAAACAGCACAGCTCTGAGTAGTTTATTCCCTTCATCATTTACTGAAAATTGTGAATTACTGTCATGCTCAGGGGAGA ATAGAACTATGGTGCATTCTCTTAATAGCACTGCTGATGAAAGTGGACTAAATAAACTTAAAATTAGGTATGAAGAATTTCAAGAACATA AAACAGAAAAGCCAAGCCTCAGCCAGCAAGCAGCACACTATATGTTTTTTCCCAGTGTTGTTCTTTCTAACTGTCTTACTAGACCACAGA AACTATCTCCTGTCACATATAAATTACAACCTGGCAATAAACCATCCCGGTTAAAATTGAATAAAAGGAAACTTGCAGGTCATCAGGAGA CTTCTACCAAAAGTAGTGAGACTGGATCCACAAAAGATAATTTTATACAAAATAATCCTTGTAATAGTAATCCTGAGAAGGATAATGCAT TGGCTAGTGATTTAACTAAAACCACTCGTGGAGCTTTTGAAAATAAAACACCCACAGATGGTTTTATAGACTGTCACTTTGGAGATGGAA CGTTAGAAACTGAGCAGTCCTTTGGACTATATGGAAATAAATACACACTTAGAGCCAAACGCAAGGTAAATTATGAGACTGAAGACAGTG AGTCAAGTTTTGTAACTCACAACTCAAAAATTAGTCTACCTCATCCCATGGAAATTGGTGAAAGTTTAGATGGAACTCTCAAATCCCGAA AACGAAGAAAAATGTCTAAAAAGCTGCCCCCTGTCATCATAAAGTATATTATTATTAATAGATTTAGAGGGAGAAAAAATATGCTTGTGA AGCTAGGAAAAATAGACTCTAAAGAAAAACAAGTAATATTAACAGAAGAAAAAATGGAACTATATAAAAAGCTTGCACCTTTGAAGGACT TTTGGCCAAAAGTTCCCGACTCCCCTGCAACCAAATATCCCATTTATCCACTAACACCAAAGAAAAGTCACAGAAGAAAGTCAAAACATA AATCTGCTAAGAAAAAAACTGGTAAACAACAAAGGACAAATAATGAAAATATTAAAAGAACTTTGTCTTTCAGGAAAAAACGGTCACATG CTATTCTTTCTCCTCCCTCACCATCTTACAATGCTGAAACCGAAGATTGTGACCTGAATTATAGTGATGTTATGTCTAAACTAGGTTTTC TTTCTGAGAGAAGCACAAGTCCCATAAATTCTTCTCCACCTCGCTGCTGGTCTCCCACAGATCCAAGAGCTGAAGAAATCATGGCTGCTG CAGAAAAAGAGGCAATGCTTTTTAAGGGTCCTAATGTATATAAGAAGACTGTTAATTCTCGTATAGGAAAAACTAGTCGCGCAAGAGCAC AGATTAAGAAATCAAAAGCAAAGCTTGCTAATCCCTCTATAGTTACTAAGAAAAGGAACAAACGAAATCAGACAAATAAACTAGTAGATG ATGGAAAAAAGAAACCAAGAGCAAAACAAAAAACAAATGAGAAAGGTACATCGAGAAAGCATACAACACTTAAGGATGAAAAAATAAAAT CTCAGTCTGGTGCTGAGGTTAAGTTTGTACTGAAACACCAGAATGTGTCTGAATTTGCAAGTAGTTCTGGAGGCTCTCAACTACTTTTTA AACAGAAAGATATGCCACTAATGGGCTCTGCTGTAGATCATCCCCTTTCTGCTTCCCTACCCACTGGAATTAATGCACAACAGAAGTTAT CTGGCTGCTTTTCTTCTTTCTTAGAAAGCAAGAAGTCTGTAGATTTGCAGACATTCCCCAGTTCACGAGATGATTTGCATCCATCAGTTG TTTGTAATTCTATAGGACCTGGAGTCTCAAAAATTAATGTTCAAAGGCCTCATAATCAAAGTGCTATGTTTACTCTAAAGGAATCAACGT TAATTCAAAAAAATATATTTGACCTTTCCAATCATTTATCTCAGGTAGCACAGAATACACAGATATCTTCTGGTATGTCCTCAAAGATAG AAGATAATGCAAATAATATACAAAGAAACTATTTGTCATCAATCGGAAAGTTAAGTGAATATCGCAATTCCCTAGAATCAAAGCTGGACC AAGCATATACCCCTAATTTTTTGCATTGCAAAGACAGTCAGCAGCAGATTGTGTGCATAGCGGAACAGTCAAAGCACAGTGAAACTTGTT CTCCGGGAAATACAGCTTCAGAGGAAAGCCAAATGCCTAATAATTGCTTTGTAACTTCCTTGAGAAGTCCAATCAAACAAATAGCATGGG AGCAAAAGCAAAGGGGCTTTATTTTAGATATGTCAAATTTTAAACCTGAAAGAGTAAAACCGAGGTCGTTATCAGAAGCAATTTCACAAA CCAAAGCACTTTCTCAGTGTAAAAATCGAAATGTGTCAACACCTTCAGCATTTGGTGAAGGACAGTCTGGACTGGCAGTTCTAAAAGAAT TGTTACAAAAAAGACAGCAGAAAGCACAAAATGCAAATACTACACAAGACCCATTATCCAATAAACATCAACCAAATAAAAATATTTCTG GTTCCCTTGAGCATAACAAAGCAAATAAACGGACACGATCGGTAACGTCCCCAAGAAAACCTCGAACTCCCAGAAGTACAAAACAAAAAG AAAAAATCCCCAAACTTCTCAAAGTAGACTCTTTAAATTTACAAAACTCTAGCCAGTTGGATAACTCTGTATCAGATGATAGTCCCATCT TTTTTTCAGATCCAGGCTTTGAAAGTTGTTACTCACTTGAAGATAGTTTATCTCCTGAACATAATTATAATTTTGATATTAACACAATAG GTCAGACTGGATTTTGTAGCTTTTATTCTGGAAGTCAGTTTGTCCCAGCTGATCAGAATTTGCCTCAGAAGTTCCTAAGTGATGCTGTTC AGGATCTTTTTCCAGGACAAGCTATAGAAAAAAATGAGTTTTTAAGTCATGACAACCAGAAATGTGATGAAGACAAGCATCATACCACAG ACTCAGCCTCATGGATTAGATCTGGTACTTTAAGTCCTGAAATTTTTGAGAAGTCAACCATAGATAGCAATGAGAATCGTCGCCACAACC AGTGGAAAAATAGCTTTCATCCTCTAACAACTCGGTCTAACTCAATAATGGATTCTTTCTGTGTTCAGCAGGCAGAAGACTGTCTAAGTG AAAAATCTAGATTGAATAGGAGTTCAGTAAGCAAAGAAGTGTTTCTTAGCCTCCCACAGCCAAACAATTCAGACTGGATTCAAGGTCACA CCAGAAAAGAAATGGGACAGTCTCTTGACTCAGCCAATACCTCTTTTACTGCAATACTCTCCTCCCCTGATGGTGAACTTGTAGACGTGG CCTGTGAAGATTTAGAACTGTATGTTTCAAGAAACAATGATATGTTGACACCAACTCCTGATAGTTCACCAAGATCTACTAGCTCTCCTT CACAATCTAAAAATGGCAGCTTCACCCCTCGAACTGCTAACATTCTGAAACCACTTATGTCCCCCCCAAGTAGGGAAGAAATTATGGCAA CTTTGTTGGATCATGACCTGTCTGAGACTATTTACCAGGAACCATTTTGCAGTAATCCTTCTGATGTACCAGAAAAGCCCAGGGAGATTG GTGGACGGCTCCTCATGGTAGAAACTCGACTTGCAAATGATCTGGCTGAGTTTGAGGGAGACTTTTCCTTGGAAGGACTTCGTCTTTGGA AAACAGCATTCTCAGCAATGACTCAGAATCCAAGGCCAGGGTCACCCCTTCGCAGTGGCCAAGGAGTTGTCAATAAAGGGTCAAGTAATA GCCCTAAGATGGTTGAAGATAAAAAAATTGTGATTATGCCTTGCAAATGTGCCCCAAGTCGACAACTGGTTCAAGTGTGGCTTCAAGCCA AAGAAGAATACGAACGTTCCAAGAAACTGCCTAAAACCAAGCCAACTGGAGTTGTAAAATCTGCTGAGAACTTTAGCTCTTCAGTTAACC CAGATGACAAACCTGTAGTGCCTCCAAAAATGGATGTAAGTCCATGTATACTCCCCACTACAGCACATACCAAGGAGGATGTTGATAATT CTCAGATTGCTTTACAAGCACCAACCACGGGATGTAGTCAAACTGCAAGTGAAAGTCAGATGCTGCCACCAGTTGCCTCTGCAAGTGATC CCGAAAAAGATGAAGATGATGATGATAACTATTACATTAGTTATAGCTCCCCTGATTCTCCAGTAATTCCCCCTTGGCAACAACCAATAT CCCCAGATTCCAAAGCATTAAATGGAGATGATAGACCCTCATCACCAGTAGAGGAGCTGCCTTCATTGGCTTTTGAGAACTTCTTAAAGC CAATAAAAGATGGTATACAAAAAAGCCCCTGCAGTGAGCCTCAAGAGCCTCTAGTGATATCTCCAATTAATACTAGGGCAAGAACTGGGA AATGTGAATCACTTTGCTTTCATAGTACACCAATCATACAGAGAAAACTTCTGGAAAGGCTTCCTGAAGCACCTGGCCTTAGCCCATTAT CAACAGTGATCCTGCCATGAAGCAGTTTCTGCTGTACTTGGATGAGTCCAATGCCCTGGGGAAGAAGTTCATCATTCAAGACATTGATGA CACTCACGTCTTTGTAATAGCAGAATTGGTTAATGTCCTCCAGGAGCGAGTGGGTGAATTAATGGACCAAAATGCTTTTTCCCTTACCCA GAAATGAAAATACTCAATATGGACCATTTAGGAATTATAAGCAGCAACTGTGAAAGACTTGCCACTCAATATCTTAGGTGACTGATTAGA CATAGAGGGTTGTTTTAGGAGCATGCCACGGGAAAGACTGAGGGATCATGATCATTTGTTCAGAAAAAAAGCCCCTGAACTGATTTTGTT ACCATAGAATTTAAAAAAAAAAAAAGCTTTAACAGTTGGCTGTAATTTGGCTTTTATTATCCTTTATTAAAATACAAATGTCAATGCTTT TCCTGCCTTTTTAATACCATGTCAGTGTAACATAGGTATTTATTTTGCTCATCCCTGTGATCTGTGCATTTTTGCTGCGTGGATGTGATT GTTTGGTTTCAGTTAGAAACGTCATAGATTTGCTGTTTGAATATGCCAAGGTGGGGACTTAGACATTATGTACGTCTCACAAATCCTACC TGCATACCAGTCAGCTCTATTGAGGAAGACAATGTAAAACTAATGTAAACTACAGTTTGCATTTCCCTGAAAACAGAATATTGTTTTTAA GAGGGTTAGAAACAACCAGTGGGAAAGGCACATGCTGCTTTGTTTAGTTTTTCCTTGTTCAAACTTTGTTGGTCACATTTTCCCATCTGT ATTCTTTTTTATTAAGAAAACAGCTTAGGGAGGCTGAGGTGGGAGGATTGCTTGAGCCCAGGAGTCCGAGGTTGCTACAAAAACACCATT GCACTCTGGCCTGGACAACAGAGAGACCCTGCCTCAAAAAAAAAAAAAAAAAAAAAAAAAATTCTACTTGTACCTTATTCCCTATGAGAA TACTTATCAAACTTATCTAAAAAAGAAAAATAGGAACAGCCATATGCAAAGTCAGCCCAACAGGAAAGGACATATTAGATTAAAATACAT TGCGGCCTGGGCTTAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATCGCTTGAGTCCAGGAGTCGAAACCC TGTCTCTACAAAAAAAAAAATACAAAAATCTGCCTGTTGTCCCAGCCACTGGGGAGGCTGAGGTAGGAGGTCAAGGCTGCAGTGAACCTT GATCATTGCTACTGCCACTCCAGCCTAGGTGACAGAGTGAGACCCTGTCTCCAAAAAAAAAAGTGTATATGTATGTGTGTATATATAGCA AGAGAGAGTTCTGTGATCAATTGAAGGCAAAAACAGTAACACTGAGAGGGGCTTTGCTTCCCTTCCTGAAGATCATGTCATTGGGGTGGG TTCCTGTAAAGGGAATTTTCCAAGAGAAAAGAGAATTTTCATGACCTGTAGACTCTTACAAATCCATTTTACCTGCTTCCTTATGGTATG TTTATTCAAAGCACCTGTGTACCATATTTATTCACTTACACAGCATTACTGAATCTGGAAATTTTCAGTTAGGTATATTTTACATAATTC CCACCCATATAACTCAGTCCATACAGTTCACAGTTTTCATTCCCTCATAGCAATGCAAAAAATTTTGATGAGTTACTACTACTAAAACTA GTTAAGTAAAAGATGATTCTTAAGAATTTCCAGGCTGGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCA GCTCACGAGGTCAGGAGATCGAGACCATCCTGCTCGGTGAAACCCCATCTCTATTAAAAATACAAAAAATTAGCCGGGCCTGGTGGCGGG TGCCTGTAGTCCCATCTACTCAGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTAAGCTGAGATTGTGCCAC TGCACTCCAGCCTGGGCGACAGAGGGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAATGAATTTCCAGCTATACCAAAATGTTACTAA TGTATCTTATATTTCAGGCATGTCTAAATCAACTTTTAGTATGCCTCAGGCATTTGTCACCAACCTTTTATATTAACATGAAACTTAGAA AATTTTTGATAGAATCCCAGAGTTCAAAAGGTATTAGGATTTTTGCCACTGAAGTAAAAAAGAGAAAAAAAGATATTTATGAGAAAACTA TTGAACAGTGACTGTGTTGTACCCGAGCAAGTTAGAGGAACGCCACACTTTGAGACGAATTTAAAAGTCCTTTATTTAGCTGGCAGCCAA GAGGTGGCTCACACTTGGAATTCTCTCAGCTCCGAGGAAGGGGCTTGATTTTCCTTTATACTTTGGTTTAGGAAGGGGACGGGAGCTCAG TTGCAACAATTCTACAGAAGTAAAAACATGCAAAAAATTAAAAAGACAAATGGTTACAGAGAAACAAACAGTTCCAGGTGCAGGGGCTCT AAATCTATCATAAGATGTCAGGTGTGGGGGCTCTGCCAGACACAAACTCAAGGCTTTATGGTGTATCTCTTGAGCGAAATCCTGGGAACT TCGTACATTGCTTGCTTCAGTACCTTATGAGTTAATTGGACTCTTTGATATGTTGAGAGTCAGCTTACACAAGTTAACTCCTTGAGGAAA GGGGGTGGGTAAGGAGTCCTTGATGTCCTGTAAATGAAGGAACCAAATGGAGTTCCTCCGGCTTTCTCAGCTAAGGGAGAGCTTATTCAC ATGGAAACAAGGCTAGGTGATTAAGGGAGAAAGGGACAGTCTGAAAACAAGGTTAGTAAAAACAAGGTTAGGTATTAGAACTGCAAAGAG TATTAAGTGAAATAAGTGAAGGAAAATATGAGCTCTTATTTTTAAAAAGTTGTGTTGGGGCAAATGTTAAATATCTTTCTTTCTCTGGAC ATTATTAAGAAAGATAGAGTGATGTGAATGATAGGAAGCCCACCTGTAACCACTTAGCTGACATGTCCAACTATGGGTGAACAGGAAATA AGCGACATTCACCTAGGCTGTTTATTGGAATCTGACTAGCATTATTTGATTTGGCATACTTTACATGTCCAGAACAAGGCTGTTGGTGCT TGGCACCAAGAAATTTATGACTTTTTTTTTTTTTTTAAATAAAGTCCTAAAGGTAGCATTAAAATGACTTAACTGGAGGCAGGAGGATCA CTGAAGCCCAGGAGTTTGAAGCTGCAGTAAGCTAAGAAGGTGCCACTGCACTGCAGCCTGGATGACAGAGTGAAACTTTGTCTCTTAATA GAACTATGGACTGAAGTTGTGATATTGAGTGTTATATTTCTCAATAAAGGTTTTTTCTTTTAATACTGTATTAGGTCAAATTCAAGGTCT TAATTCCTTGAATTCCAATTTCCTTGTGAAATTTCATGTGATTAATTTAAAATTCCAGGGATCCTATCTAACATCACAGTTGATGGATAT AACAATGTATTTTGAGAAATCAGTTTTGGTGAACAGTAACAGCATTACTGATAATAGGCAACAAACACTACTGCATTTTATTTCTGATAG GCATTATAGGTGGTAATCCAAATGATTAATGATTTTATTGCTCTTTACATTTTCTAGAACAGGTGATTTGACATAATTGTACTTTTTTCT GAGAAGTTGGTAGTGTACTTACTACTCTATTTTGCAGTTATACAATAAATCTTACTTAGCTGACAACTAGGAGTAAAAGCTCTGACAAAA AGCCTCTGCTGTAACTAAAATACTGAGATCATTCTATCTTAACAAACTTAACAGATGGGGAAGGGGTATATTTTAAAGATGGAGAAATGA TGCAGTTTGCAAATATAGTCAATAAATATTCTCAAGTGTACGTAGCTCAATTTCATTTGCAGCAAAGATAACACTGAAATGTCTATGGAT GAGATTATTGGATAAACTTTTTTAAAAACACTGTTCTCAAGATAGGCAAGTGATTAAGAGCACTGACTGGGCCGGGCGCGGTGGCTCACG TCTATAATCCTAGCACTTTGGGAGGCCGAGGCGGGCAAATCACAAGGTCAGGAGATCAAAACAATCCTGGCTAACAAGGTGAAACCCCGT CTCTACTAAAAATACAAAAAAATTAGCTGGGCATGGTGGTGGACGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGTGT AATCCCGGGAGGTGGAGGTTGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCGGGGTGACAGAGCGAGACTCCCACCCATCTCAAAA AAAATAAAAATGAAAAGCACTGATTGAATCTAGATTCCTTGAGTCCAAGTGTCAGATCTCTGCTTACTAGCTCTGGGATCTCAGATGTTT CGTTGATTGGATTTCTTTGTGCTCATTTGTGTAAACAGGAATGCCCGTCTTTAAAGACTATTAAAATGAATGTGAGTTAACACACAAGAG GTCTTCAAAAAGTTGATGGAAAATGCATATTATGAAAAAAATTATGCATAGATTTCAAAAATCTTTGCAGCAAAATAAACTCATCATTAT AACATGTCTGAACAGGATCTAGTTTGAGGCACTAAGAAGGATATCAGTTTAAATAGAGCCCCTGTCAGAACAATATGAATTCTGCTAAAA CTGAAGCAAGAACAAACATCAAATTTATGGCAAAGCTTAGGTGGAAGAATGGTGCAATCATTGATGCTTTGCAAAAAGTTTATGGGAACA ACGCCCCAAGGAAATCAGTTTACAAATGGATAATTCATTTTAAGAAAGGACAAGACAATGTTGAAGATGAAACCTACAGCAGCAGACCAT GCCACTTCGTGAGGAAAAAATTATCTCATTCATGCCCTACTTGAAGAGGACCAATGATTAACAGCAGAAACGATAGCCAACACAATATGC TCCTCAGTTGGTTCAGCTTTTATAAATCTGACTGAAAAATTAAAGTTGAGCACACTTTCCACTCAATGGATACCAAAACCATCCAGCCCA GGTCAGCTGCAGACAAAAGCAGAGCTTTCGATGGAAATGTCAAACAAGTGAGATCAAGATCCTGAAGCATTTCTTCAAAGAATTGTAGCA AAAACAGACTTTTAAAACCTTGAATTCAGAGACAGGTATAAAGACTGCTTGGTGATTTTGAAAGGACTGAGATCATTTTGGGAGAGATCA TCTTCAGAAAATGACCAGATACAACAAGAATTTAACATGGCAGCCAAACCAACCCACTAACACACATTTAAATAAGATACCCAAATGCAG AAAGAAAAGCACAGTCGTCATGCAAAATAGTCACTACTCATTCAAAAACTCTATAGTTGTCTGAGTCGTTATGCTCAAAATATCCAATAA TATTTCTTTTGCTGAGCTGTAAAATAATTATTTTGCAAACATAAAAGAAAAAAAAAAGAATTGTAACAGAAACATGGCTTTACCAGTATG ACCCTCAAGACAAAATACAAAACAATGGCTACCAAGAGGTGGAAGTGGCCCAGTCACAGCAAGAGCAGATTGATCAAGAGCAAAGGTCAT GGTAACAGTTTTTTGGATCCTCAAGTCATTTTGCTTGTTGACTTTTTGGAGGGCCAAATAAAGATATCATCTGCTTATTATGAGAGTGTT TCGAGAGAAATCCAAAGCTTAGCAGAGAAACGCCTGGGAAAGCTTCACCAGAGGGTCTTCCACCGTGACAGTTCCCCTGCGCATTCCTCT CATAAAGCAAGGGCAGTTTAGCTAGAATTTCTATCAAAAATCATTAGGTATCCATCTCCCAGTCCTGATTTGGCTCCTTCTGACTTCTTT TTGTTTCCCAATCTTAAAAAAATCCCTGAAGGGCACCTGTTTTTCTTCAGCTAATAAAAAAGACATGGTTAATTTCCCAGGACCCTCAGT TCTTTAGGGATAGACTGAATGGCTGGTATCATTGCTTGAACTTAATGGAGCTTATGTTGAGAAATAAAAGAAATTATATTTTATTTTTAT CTTTTAATTCTATTTTTCCATGAACTTTTTGAAGTCCCCTCAGATATAAAGCAGAACGTTATGAAACTGAGTTACCTTGAATCTAGAAGA GTACAATGATAAAGGGGAAGATAGAAACACACACATATGCGTTGTTTTCCCCACTTTCACAATGCCGTGCAGAAACTAACAGATGAAGGA GGAGAATCCCTAAAAACAGAGCATTGGGTAGCTAGTCCACCAGCGGTCTGATGCTTTCATTGATCTCAAAACTGTCTCTGAGTAACTCTA CCAGGAAAGTTGTCTGGAGGGTTAACATTTCTGAAACCATTTTTATCTTTGCCTTCATTCTTGAATGATAATTAGTCTCGAATGTTTGGA TCACAATCCATTGAAAGACTAGGCTATTTTTTCACTGTCCTCAGACATTTACTGAGTCCAGTTTGGACTTTATTTTATTTTATTTTTTTT GAAACAAGATCTCGCTCTGTTGCTCAGGCTGAAGTGCAATAGCGCAAACTCGGCTCACTGCAACCTCCCAGGTTCAAGCAATTCTCGTGC CTCAGCCATCCCTATAGGCATGCGCCACCACACTTTGCTAATCTTGTATTTTTGGTAGAGACGGGGTTTGCACCATGTTGGCCAGGCTGG TCTCGAACTCCCAACCTCAAGTAATCTGGCCTCCCAAAGTGGTGGGATTACAGGCGTGAGCCAGCGCGCCCGGCCTGGACTTAACTTCTG AAGAACTCTTTCTGTTTAGATTGCAGGAGCGTTCTCTCGGCTCATCTCTTGTTTTCTCACCCAGCTGTTCTTCTTCTAGTTGGCCATCAT TCTTCATCCCTCCCTCCCTTTCCTGCAGTTAATTATTTCTTTGAAATTTTAAAACTTCTTAATGTTGCCTGGAATACATGAGTCTTCCTG ATCTCTTCAAACGGGGTTTGTTTTGTTTTGCTTTGGGGAGAATTCTTTTGACGTTTTTGAATAAGCTGTTAACAACTTTAATACCTGTCT TGTTTGTTTTCTTCAGAAATTTGTTAATTCTCCATGATTAGCACCTTTATGTGGTTATCTCATTATTTTCATTCCTTTTTAATTCTCTGT TTTAGGAATGCTTGTCAAATTCGTCACTAAAATTGATTTACTTTCTTGAAAACCTGTTTCTGCTGCTCCCAACATGATTTAATCTTGGCT ACTGAGCTTTTGGTTACGTTGCACTCCCTTTAAAATTACTCCGTTTAAGTACAGTGTTCACTCTTTGGGTAATGTGTACAATAGAAGCCC >In-frame_ENST00000368805_ENST00000607778_TCGA-37-4129-01A_REV3L_chr6_111688318_-_GTF2H5_chr6_158613009_length(amino acids)=2228AA_start in transcript=83_stop in transcript=6769 MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAGQKTCLHLHGIFPYLYVPYDGYGQQPESYLSQMAFSIDRALNVA LGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYNPTMVKRICELLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAV KFRKARRKSNTLHATGSCKNHLSGNSLADTLFRWEQDEIPSSLILEGVEPQSTCELEVDAVAADILNRLDIEAQIGGNPGLQAIWEDEKQ RRRNRNETSQMSQPESQDHRFVPATESEKKFQKRLQEILKQNDFSVTLSGSVDYSDGSQEFSAELTLHSEVLSPEMLQCTPANMVEVHKD KESSKGHTRHKVEEALINEEAILNLMENSQTFQPLTQRLSESPVFMDSSPDEALVHLLAGLESDGYRGERNRMPSPCRSFGNNKYPQNSD DEENEPQIEKEEMELSLVMSQRWDSNIEEHCAKKRSLCRNTHRSSTEDDDSSSGEEMEWSDNSLLLASLSIPQLDGTADENSDNPLNNEN SRTHSSVIATSKLSVKPSIFHKDAATLEPSSSAKITFQCKHTSALSSHVLNKEDLIEDLSQTNKNTEKGLDNSVTSFTNESTYSMKYPGS LSSTVHSENSHKENSKKEILPVSSCESSIFDYEEDIPSVTRQVPSRKYTNIRKIEKDSPFIHMHRHPNENTLGKNSFNFSDLNHSKNKVS SEGNEKGNSTALSSLFPSSFTENCELLSCSGENRTMVHSLNSTADESGLNKLKIRYEEFQEHKTEKPSLSQQAAHYMFFPSVVLSNCLTR PQKLSPVTYKLQPGNKPSRLKLNKRKLAGHQETSTKSSETGSTKDNFIQNNPCNSNPEKDNALASDLTKTTRGAFENKTPTDGFIDCHFG DGTLETEQSFGLYGNKYTLRAKRKVNYETEDSESSFVTHNSKISLPHPMEIGESLDGTLKSRKRRKMSKKLPPVIIKYIIINRFRGRKNM LVKLGKIDSKEKQVILTEEKMELYKKLAPLKDFWPKVPDSPATKYPIYPLTPKKSHRRKSKHKSAKKKTGKQQRTNNENIKRTLSFRKKR SHAILSPPSPSYNAETEDCDLNYSDVMSKLGFLSERSTSPINSSPPRCWSPTDPRAEEIMAAAEKEAMLFKGPNVYKKTVNSRIGKTSRA RAQIKKSKAKLANPSIVTKKRNKRNQTNKLVDDGKKKPRAKQKTNEKGTSRKHTTLKDEKIKSQSGAEVKFVLKHQNVSEFASSSGGSQL LFKQKDMPLMGSAVDHPLSASLPTGINAQQKLSGCFSSFLESKKSVDLQTFPSSRDDLHPSVVCNSIGPGVSKINVQRPHNQSAMFTLKE STLIQKNIFDLSNHLSQVAQNTQISSGMSSKIEDNANNIQRNYLSSIGKLSEYRNSLESKLDQAYTPNFLHCKDSQQQIVCIAEQSKHSE TCSPGNTASEESQMPNNCFVTSLRSPIKQIAWEQKQRGFILDMSNFKPERVKPRSLSEAISQTKALSQCKNRNVSTPSAFGEGQSGLAVL KELLQKRQQKAQNANTTQDPLSNKHQPNKNISGSLEHNKANKRTRSVTSPRKPRTPRSTKQKEKIPKLLKVDSLNLQNSSQLDNSVSDDS PIFFSDPGFESCYSLEDSLSPEHNYNFDINTIGQTGFCSFYSGSQFVPADQNLPQKFLSDAVQDLFPGQAIEKNEFLSHDNQKCDEDKHH TTDSASWIRSGTLSPEIFEKSTIDSNENRRHNQWKNSFHPLTTRSNSIMDSFCVQQAEDCLSEKSRLNRSSVSKEVFLSLPQPNNSDWIQ GHTRKEMGQSLDSANTSFTAILSSPDGELVDVACEDLELYVSRNNDMLTPTPDSSPRSTSSPSQSKNGSFTPRTANILKPLMSPPSREEI MATLLDHDLSETIYQEPFCSNPSDVPEKPREIGGRLLMVETRLANDLAEFEGDFSLEGLRLWKTAFSAMTQNPRPGSPLRSGQGVVNKGS SNSPKMVEDKKIVIMPCKCAPSRQLVQVWLQAKEEYERSKKLPKTKPTGVVKSAENFSSSVNPDDKPVVPPKMDVSPCILPTTAHTKEDV DNSQIALQAPTTGCSQTASESQMLPPVASASDPEKDEDDDDNYYISYSSPDSPVIPPWQQPISPDSKALNGDDRPSSPVEELPSLAFENF -------------------------------------------------------------- >In-frame_ENST00000358835_ENST00000607778_TCGA-37-4129-01A_REV3L_chr6_111688318_-_GTF2H5_chr6_158613009_length(transcript)=14496nt_BP=7128nt CGAGATCTGCGCCTCGCCTCCCTCCTCACGCGGGCGGATTTTCTTACCTTGTGAAAAACCGTCTCAGCGGCTGCCCCCGCCTCCTCTGCT GGATGTGAAATGGCGGTCGGCGAGTGGTTGCGTCCGTGACATCATCATCATGGCAACAAGAGCTGCAGCCTGGGACCGAGGAGCCCGTGT GATTCCCGGCGGTGGCGGCAGTGGCGGCAGCACCAGCACCGACGAAAGCTCGAGGGCTTCTCTCCTGCGGCCCCTTGCCGGGTGCTCCTG AGGAGGCGGCGGCAGCAGCGCCTACACCGCCCCGCCCGCCGCTCCTCGAGGTGCCTCTGTGTGAGGGGAGGGGGCCGTGCCGAGAAGGGG AGGGGGCGCCGCCGCCGCTGCGGAGGGAGCCGCCGCCGCTGCTGCTGCCGCTGCCGGGTCGCCAGTGAAGGGAGGCAGTGGCGGCGGCGG CGAACATGTTTTCAGTAAGGATAGTGACTGCAGACTACTACATGGCCAGCCCGCTGCAGGGGCTGGATACCTGCCAATCCCCCCTCACCC AGGCCCCTGTCAAGAAGGTGCCGGTGGTGCGAGTCTTCGGAGCGACCCCGGCAGGTCAGAAGACATGTCTTCATCTACATGGCATCTTTC CTTACCTCTATGTGCCATACGATGGTTATGGACAGCAGCCAGAAAGCTATCTTTCTCAGATGGCATTCAGTATCGACAGAGCACTTAATG TGGCTTTAGGCAATCCATCTTCCACTGCTCAGCATGTGTTCAAAGTGTCATTAGTATCAGGAATGCCTTTTTATGGTTATCATGAGAAGG AAAGACACTTTATGAAGATCTATCTTTACAATCCTACAATGGTGAAAAGGATATGTGAACTTTTGCAAAGCGGAGCCATAATGAATAAAT TTTACCAGCCTCATGAAGCGCATATTCCCTACCTCCTACAGCTCTTCATTGACTACAATCTTTATGGCATGAATTTAATAAATCTGGCTG CTGTCAAGTTCCGAAAAGCAAGAAGGAAAAGTAATACATTGCATGCAACTGGATCCTGCAAGAATCATTTATCAGGAAATTCTCTTGCTG ATACTTTATTTCGGTGGGAACAAGATGAAATACCAAGCTCTTTAATATTGGAAGGTGTTGAACCACAGAGTACATGTGAATTAGAAGTGG ATGCTGTAGCTGCTGATATCTTAAATCGTCTGGACATTGAAGCTCAAATTGGTGGAAACCCTGGTCTACAGGCCATATGGGAAGATGAAA AGCAACGGCGAAGAAACAGAAATGAAACTTCTCAAATGAGCCAACCTGAGTCACAAGATCACAGGTTTGTGCCAGCAACAGAAAGTGAAA AAAAATTTCAGAAGAGACTTCAGGAAATTCTCAAACAGAATGATTTCTCTGTAACATTATCAGGATCTGTGGACTACAGCGATGGATCCC AGGAGTTCTCTGCTGAGTTAACATTGCACTCTGAGGTTCTGTCTCCTGAAATGCTTCAGTGTACACCAGCCAATATGGTAGAAGTTCACA AAGACAAAGAGTCAAGCAAAGGTCACACTAGACACAAAGTGGAAGAAGCTCTTATTAATGAAGAAGCAATTTTGAACCTTATGGAAAATA GTCAGACTTTTCAGCCTTTGACCCAAAGACTGAGTGAGTCACCTGTTTTCATGGACAGTAGTCCTGATGAGGCTCTGGTACATCTTCTTG CTGGTTTGGAAAGTGATGGATATCGGGGGGAAAGAAATAGGATGCCATCACCATGTCGCTCCTTTGGAAATAATAAATATCCACAAAATA GTGATGATGAAGAAAATGAACCACAGATTGAAAAAGAGGAAATGGAGCTTAGTTTGGTGATGTCCCAGAGATGGGACAGCAATATTGAAG AACATTGTGCCAAAAAGAGATCACTGTGCAGAAATACCCACAGAAGTTCAACTGAAGATGATGACTCATCTTCAGGAGAAGAAATGGAAT GGAGTGATAACAGTTTGCTTCTAGCCAGTCTTTCTATACCTCAGTTAGATGGAACTGCAGATGAAAATAGTGACAATCCATTGAACAATG AAAATTCTAGAACCCACTCTTCTGTAATTGCAACAAGCAAGCTTTCAGTTAAACCCTCCATCTTTCACAAAGATGCTGCTACATTAGAAC CCTCATCTTCTGCTAAGATTACCTTTCAGTGTAAACACACAAGTGCCCTTTCTTCCCATGTTTTGAACAAGGAAGATTTAATTGAAGACC TTTCACAGACAAACAAAAATACAGAAAAAGGTCTAGATAACTCAGTCACTTCTTTTACAAACGAAAGCACTTATTCTATGAAATACCCTG GATCTTTAAGCAGTACTGTTCATTCAGAAAATTCTCATAAAGAGAATAGTAAGAAAGAGATCCTCCCAGTATCTTCCTGTGAAAGTAGTA TTTTTGATTATGAAGAAGATATTCCATCTGTTACAAGACAAGTACCAAGTAGAAAATATACAAACATTAGAAAAATCGAAAAGGATTCCC CTTTTATACATATGCACCGTCACCCTAACGAGAATACATTGGGCAAAAATTCTTTCAACTTTTCTGACTTAAATCATTCAAAAAATAAAG TATCCTCTGAAGGAAATGAAAAAGGAAACAGCACAGCTCTGAGTAGTTTATTCCCTTCATCATTTACTGAAAATTGTGAATTACTGTCAT GCTCAGGGGAGAATAGAACTATGGTGCATTCTCTTAATAGCACTGCTGATGAAAGTGGACTAAATAAACTTAAAATTAGGTATGAAGAAT TTCAAGAACATAAAACAGAAAAGCCAAGCCTCAGCCAGCAAGCAGCACACTATATGTTTTTTCCCAGTGTTGTTCTTTCTAACTGTCTTA CTAGACCACAGAAACTATCTCCTGTCACATATAAATTACAACCTGGCAATAAACCATCCCGGTTAAAATTGAATAAAAGGAAACTTGCAG GTCATCAGGAGACTTCTACCAAAAGTAGTGAGACTGGATCCACAAAAGATAATTTTATACAAAATAATCCTTGTAATAGTAATCCTGAGA AGGATAATGCATTGGCTAGTGATTTAACTAAAACCACTCGTGGAGCTTTTGAAAATAAAACACCCACAGATGGTTTTATAGACTGTCACT TTGGAGATGGAACGTTAGAAACTGAGCAGTCCTTTGGACTATATGGAAATAAATACACACTTAGAGCCAAACGCAAGGTAAATTATGAGA CTGAAGACAGTGAGTCAAGTTTTGTAACTCACAACTCAAAAATTAGTCTACCTCATCCCATGGAAATTGGTGAAAGTTTAGATGGAACTC TCAAATCCCGAAAACGAAGAAAAATGTCTAAAAAGCTGCCCCCTGTCATCATAAAGTATATTATTATTAATAGATTTAGAGGGAGAAAAA ATATGCTTGTGAAGCTAGGAAAAATAGACTCTAAAGAAAAACAAGTAATATTAACAGAAGAAAAAATGGAACTATATAAAAAGCTTGCAC CTTTGAAGGACTTTTGGCCAAAAGTTCCCGACTCCCCTGCAACCAAATATCCCATTTATCCACTAACACCAAAGAAAAGTCACAGAAGAA AGTCAAAACATAAATCTGCTAAGAAAAAAACTGGTAAACAACAAAGGACAAATAATGAAAATATTAAAAGAACTTTGTCTTTCAGGAAAA AACGGTCACATGCTATTCTTTCTCCTCCCTCACCATCTTACAATGCTGAAACCGAAGATTGTGACCTGAATTATAGTGATGTTATGTCTA AACTAGGTTTTCTTTCTGAGAGAAGCACAAGTCCCATAAATTCTTCTCCACCTCGCTGCTGGTCTCCCACAGATCCAAGAGCTGAAGAAA TCATGGCTGCTGCAGAAAAAGAGGCAATGCTTTTTAAGGGTCCTAATGTATATAAGAAGACTGTTAATTCTCGTATAGGAAAAACTAGTC GCGCAAGAGCACAGATTAAGAAATCAAAAGCAAAGCTTGCTAATCCCTCTATAGTTACTAAGAAAAGGAACAAACGAAATCAGACAAATA AACTAGTAGATGATGGAAAAAAGAAACCAAGAGCAAAACAAAAAACAAATGAGAAAGGTACATCGAGAAAGCATACAACACTTAAGGATG AAAAAATAAAATCTCAGTCTGGTGCTGAGGTTAAGTTTGTACTGAAACACCAGAATGTGTCTGAATTTGCAAGTAGTTCTGGAGGCTCTC AACTACTTTTTAAACAGAAAGATATGCCACTAATGGGCTCTGCTGTAGATCATCCCCTTTCTGCTTCCCTACCCACTGGAATTAATGCAC AACAGAAGTTATCTGGCTGCTTTTCTTCTTTCTTAGAAAGCAAGAAGTCTGTAGATTTGCAGACATTCCCCAGTTCACGAGATGATTTGC ATCCATCAGTTGTTTGTAATTCTATAGGACCTGGAGTCTCAAAAATTAATGTTCAAAGGCCTCATAATCAAAGTGCTATGTTTACTCTAA AGGAATCAACGTTAATTCAAAAAAATATATTTGACCTTTCCAATCATTTATCTCAGGTAGCACAGAATACACAGATATCTTCTGGTATGT CCTCAAAGATAGAAGATAATGCAAATAATATACAAAGAAACTATTTGTCATCAATCGGAAAGTTAAGTGAATATCGCAATTCCCTAGAAT CAAAGCTGGACCAAGCATATACCCCTAATTTTTTGCATTGCAAAGACAGTCAGCAGCAGATTGTGTGCATAGCGGAACAGTCAAAGCACA GTGAAACTTGTTCTCCGGGAAATACAGCTTCAGAGGAAAGCCAAATGCCTAATAATTGCTTTGTAACTTCCTTGAGAAGTCCAATCAAAC AAATAGCATGGGAGCAAAAGCAAAGGGGCTTTATTTTAGATATGTCAAATTTTAAACCTGAAAGAGTAAAACCGAGGTCGTTATCAGAAG CAATTTCACAAACCAAAGCACTTTCTCAGTGTAAAAATCGAAATGTGTCAACACCTTCAGCATTTGGTGAAGGACAGTCTGGACTGGCAG TTCTAAAAGAATTGTTACAAAAAAGACAGCAGAAAGCACAAAATGCAAATACTACACAAGACCCATTATCCAATAAACATCAACCAAATA AAAATATTTCTGGTTCCCTTGAGCATAACAAAGCAAATAAACGGACACGATCGGTAACGTCCCCAAGAAAACCTCGAACTCCCAGAAGTA CAAAACAAAAAGAAAAAATCCCCAAACTTCTCAAAGTAGACTCTTTAAATTTACAAAACTCTAGCCAGTTGGATAACTCTGTATCAGATG ATAGTCCCATCTTTTTTTCAGATCCAGGCTTTGAAAGTTGTTACTCACTTGAAGATAGTTTATCTCCTGAACATAATTATAATTTTGATA TTAACACAATAGGTCAGACTGGATTTTGTAGCTTTTATTCTGGAAGTCAGTTTGTCCCAGCTGATCAGAATTTGCCTCAGAAGTTCCTAA GTGATGCTGTTCAGGATCTTTTTCCAGGACAAGCTATAGAAAAAAATGAGTTTTTAAGTCATGACAACCAGAAATGTGATGAAGACAAGC ATCATACCACAGACTCAGCCTCATGGATTAGATCTGGTACTTTAAGTCCTGAAATTTTTGAGAAGTCAACCATAGATAGCAATGAGAATC GTCGCCACAACCAGTGGAAAAATAGCTTTCATCCTCTAACAACTCGGTCTAACTCAATAATGGATTCTTTCTGTGTTCAGCAGGCAGAAG ACTGTCTAAGTGAAAAATCTAGATTGAATAGGAGTTCAGTAAGCAAAGAAGTGTTTCTTAGCCTCCCACAGCCAAACAATTCAGACTGGA TTCAAGGTCACACCAGAAAAGAAATGGGACAGTCTCTTGACTCAGCCAATACCTCTTTTACTGCAATACTCTCCTCCCCTGATGGTGAAC TTGTAGACGTGGCCTGTGAAGATTTAGAACTGTATGTTTCAAGAAACAATGATATGTTGACACCAACTCCTGATAGTTCACCAAGATCTA CTAGCTCTCCTTCACAATCTAAAAATGGCAGCTTCACCCCTCGAACTGCTAACATTCTGAAACCACTTATGTCCCCCCCAAGTAGGGAAG AAATTATGGCAACTTTGTTGGATCATGACCTGTCTGAGACTATTTACCAGGAACCATTTTGCAGTAATCCTTCTGATGTACCAGAAAAGC CCAGGGAGATTGGTGGACGGCTCCTCATGGTAGAAACTCGACTTGCAAATGATCTGGCTGAGTTTGAGGGAGACTTTTCCTTGGAAGGAC TTCGTCTTTGGAAAACAGCATTCTCAGCAATGACTCAGAATCCAAGGCCAGGGTCACCCCTTCGCAGTGGCCAAGGAGTTGTCAATAAAG GGTCAAGTAATAGCCCTAAGATGGTTGAAGATAAAAAAATTGTGATTATGCCTTGCAAATGTGCCCCAAGTCGACAACTGGTTCAAGTGT GGCTTCAAGCCAAAGAAGAATACGAACGTTCCAAGAAACTGCCTAAAACCAAGCCAACTGGAGTTGTAAAATCTGCTGAGAACTTTAGCT CTTCAGTTAACCCAGATGACAAACCTGTAGTGCCTCCAAAAATGGATGTAAGTCCATGTATACTCCCCACTACAGCACATACCAAGGAGG ATGTTGATAATTCTCAGATTGCTTTACAAGCACCAACCACGGGATGTAGTCAAACTGCAAGTGAAAGTCAGATGCTGCCACCAGTTGCCT CTGCAAGTGATCCCGAAAAAGATGAAGATGATGATGATAACTATTACATTAGTTATAGCTCCCCTGATTCTCCAGTAATTCCCCCTTGGC AACAACCAATATCCCCAGATTCCAAAGCATTAAATGGAGATGATAGACCCTCATCACCAGTAGAGGAGCTGCCTTCATTGGCTTTTGAGA ACTTCTTAAAGCCAATAAAAGATGGTATACAAAAAAGCCCCTGCAGTGAGCCTCAAGAGCCTCTAGTGATATCTCCAATTAATACTAGGG CAAGAACTGGGAAATGTGAATCACTTTGCTTTCATAGTACACCAATCATACAGAGAAAACTTCTGGAAAGGCTTCCTGAAGCACCTGGCC TTAGCCCATTATCAACAGTGATCCTGCCATGAAGCAGTTTCTGCTGTACTTGGATGAGTCCAATGCCCTGGGGAAGAAGTTCATCATTCA AGACATTGATGACACTCACGTCTTTGTAATAGCAGAATTGGTTAATGTCCTCCAGGAGCGAGTGGGTGAATTAATGGACCAAAATGCTTT TTCCCTTACCCAGAAATGAAAATACTCAATATGGACCATTTAGGAATTATAAGCAGCAACTGTGAAAGACTTGCCACTCAATATCTTAGG TGACTGATTAGACATAGAGGGTTGTTTTAGGAGCATGCCACGGGAAAGACTGAGGGATCATGATCATTTGTTCAGAAAAAAAGCCCCTGA ACTGATTTTGTTACCATAGAATTTAAAAAAAAAAAAAGCTTTAACAGTTGGCTGTAATTTGGCTTTTATTATCCTTTATTAAAATACAAA TGTCAATGCTTTTCCTGCCTTTTTAATACCATGTCAGTGTAACATAGGTATTTATTTTGCTCATCCCTGTGATCTGTGCATTTTTGCTGC GTGGATGTGATTGTTTGGTTTCAGTTAGAAACGTCATAGATTTGCTGTTTGAATATGCCAAGGTGGGGACTTAGACATTATGTACGTCTC ACAAATCCTACCTGCATACCAGTCAGCTCTATTGAGGAAGACAATGTAAAACTAATGTAAACTACAGTTTGCATTTCCCTGAAAACAGAA TATTGTTTTTAAGAGGGTTAGAAACAACCAGTGGGAAAGGCACATGCTGCTTTGTTTAGTTTTTCCTTGTTCAAACTTTGTTGGTCACAT TTTCCCATCTGTATTCTTTTTTATTAAGAAAACAGCTTAGGGAGGCTGAGGTGGGAGGATTGCTTGAGCCCAGGAGTCCGAGGTTGCTAC AAAAACACCATTGCACTCTGGCCTGGACAACAGAGAGACCCTGCCTCAAAAAAAAAAAAAAAAAAAAAAAAAATTCTACTTGTACCTTAT TCCCTATGAGAATACTTATCAAACTTATCTAAAAAAGAAAAATAGGAACAGCCATATGCAAAGTCAGCCCAACAGGAAAGGACATATTAG ATTAAAATACATTGCGGCCTGGGCTTAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATCGCTTGAGTCCAG GAGTCGAAACCCTGTCTCTACAAAAAAAAAAATACAAAAATCTGCCTGTTGTCCCAGCCACTGGGGAGGCTGAGGTAGGAGGTCAAGGCT GCAGTGAACCTTGATCATTGCTACTGCCACTCCAGCCTAGGTGACAGAGTGAGACCCTGTCTCCAAAAAAAAAAGTGTATATGTATGTGT GTATATATAGCAAGAGAGAGTTCTGTGATCAATTGAAGGCAAAAACAGTAACACTGAGAGGGGCTTTGCTTCCCTTCCTGAAGATCATGT CATTGGGGTGGGTTCCTGTAAAGGGAATTTTCCAAGAGAAAAGAGAATTTTCATGACCTGTAGACTCTTACAAATCCATTTTACCTGCTT CCTTATGGTATGTTTATTCAAAGCACCTGTGTACCATATTTATTCACTTACACAGCATTACTGAATCTGGAAATTTTCAGTTAGGTATAT TTTACATAATTCCCACCCATATAACTCAGTCCATACAGTTCACAGTTTTCATTCCCTCATAGCAATGCAAAAAATTTTGATGAGTTACTA CTACTAAAACTAGTTAAGTAAAAGATGATTCTTAAGAATTTCCAGGCTGGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGG CTGAGGCAGGCAGCTCACGAGGTCAGGAGATCGAGACCATCCTGCTCGGTGAAACCCCATCTCTATTAAAAATACAAAAAATTAGCCGGG CCTGGTGGCGGGTGCCTGTAGTCCCATCTACTCAGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTAAGCTG AGATTGTGCCACTGCACTCCAGCCTGGGCGACAGAGGGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAATGAATTTCCAGCTATACCA AAATGTTACTAATGTATCTTATATTTCAGGCATGTCTAAATCAACTTTTAGTATGCCTCAGGCATTTGTCACCAACCTTTTATATTAACA TGAAACTTAGAAAATTTTTGATAGAATCCCAGAGTTCAAAAGGTATTAGGATTTTTGCCACTGAAGTAAAAAAGAGAAAAAAAGATATTT ATGAGAAAACTATTGAACAGTGACTGTGTTGTACCCGAGCAAGTTAGAGGAACGCCACACTTTGAGACGAATTTAAAAGTCCTTTATTTA GCTGGCAGCCAAGAGGTGGCTCACACTTGGAATTCTCTCAGCTCCGAGGAAGGGGCTTGATTTTCCTTTATACTTTGGTTTAGGAAGGGG ACGGGAGCTCAGTTGCAACAATTCTACAGAAGTAAAAACATGCAAAAAATTAAAAAGACAAATGGTTACAGAGAAACAAACAGTTCCAGG TGCAGGGGCTCTAAATCTATCATAAGATGTCAGGTGTGGGGGCTCTGCCAGACACAAACTCAAGGCTTTATGGTGTATCTCTTGAGCGAA ATCCTGGGAACTTCGTACATTGCTTGCTTCAGTACCTTATGAGTTAATTGGACTCTTTGATATGTTGAGAGTCAGCTTACACAAGTTAAC TCCTTGAGGAAAGGGGGTGGGTAAGGAGTCCTTGATGTCCTGTAAATGAAGGAACCAAATGGAGTTCCTCCGGCTTTCTCAGCTAAGGGA GAGCTTATTCACATGGAAACAAGGCTAGGTGATTAAGGGAGAAAGGGACAGTCTGAAAACAAGGTTAGTAAAAACAAGGTTAGGTATTAG AACTGCAAAGAGTATTAAGTGAAATAAGTGAAGGAAAATATGAGCTCTTATTTTTAAAAAGTTGTGTTGGGGCAAATGTTAAATATCTTT CTTTCTCTGGACATTATTAAGAAAGATAGAGTGATGTGAATGATAGGAAGCCCACCTGTAACCACTTAGCTGACATGTCCAACTATGGGT GAACAGGAAATAAGCGACATTCACCTAGGCTGTTTATTGGAATCTGACTAGCATTATTTGATTTGGCATACTTTACATGTCCAGAACAAG GCTGTTGGTGCTTGGCACCAAGAAATTTATGACTTTTTTTTTTTTTTTAAATAAAGTCCTAAAGGTAGCATTAAAATGACTTAACTGGAG GCAGGAGGATCACTGAAGCCCAGGAGTTTGAAGCTGCAGTAAGCTAAGAAGGTGCCACTGCACTGCAGCCTGGATGACAGAGTGAAACTT TGTCTCTTAATAGAACTATGGACTGAAGTTGTGATATTGAGTGTTATATTTCTCAATAAAGGTTTTTTCTTTTAATACTGTATTAGGTCA AATTCAAGGTCTTAATTCCTTGAATTCCAATTTCCTTGTGAAATTTCATGTGATTAATTTAAAATTCCAGGGATCCTATCTAACATCACA GTTGATGGATATAACAATGTATTTTGAGAAATCAGTTTTGGTGAACAGTAACAGCATTACTGATAATAGGCAACAAACACTACTGCATTT TATTTCTGATAGGCATTATAGGTGGTAATCCAAATGATTAATGATTTTATTGCTCTTTACATTTTCTAGAACAGGTGATTTGACATAATT GTACTTTTTTCTGAGAAGTTGGTAGTGTACTTACTACTCTATTTTGCAGTTATACAATAAATCTTACTTAGCTGACAACTAGGAGTAAAA GCTCTGACAAAAAGCCTCTGCTGTAACTAAAATACTGAGATCATTCTATCTTAACAAACTTAACAGATGGGGAAGGGGTATATTTTAAAG ATGGAGAAATGATGCAGTTTGCAAATATAGTCAATAAATATTCTCAAGTGTACGTAGCTCAATTTCATTTGCAGCAAAGATAACACTGAA ATGTCTATGGATGAGATTATTGGATAAACTTTTTTAAAAACACTGTTCTCAAGATAGGCAAGTGATTAAGAGCACTGACTGGGCCGGGCG CGGTGGCTCACGTCTATAATCCTAGCACTTTGGGAGGCCGAGGCGGGCAAATCACAAGGTCAGGAGATCAAAACAATCCTGGCTAACAAG GTGAAACCCCGTCTCTACTAAAAATACAAAAAAATTAGCTGGGCATGGTGGTGGACGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCA GGAGAATGGTGTAATCCCGGGAGGTGGAGGTTGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCGGGGTGACAGAGCGAGACTCCCA CCCATCTCAAAAAAAATAAAAATGAAAAGCACTGATTGAATCTAGATTCCTTGAGTCCAAGTGTCAGATCTCTGCTTACTAGCTCTGGGA TCTCAGATGTTTCGTTGATTGGATTTCTTTGTGCTCATTTGTGTAAACAGGAATGCCCGTCTTTAAAGACTATTAAAATGAATGTGAGTT AACACACAAGAGGTCTTCAAAAAGTTGATGGAAAATGCATATTATGAAAAAAATTATGCATAGATTTCAAAAATCTTTGCAGCAAAATAA ACTCATCATTATAACATGTCTGAACAGGATCTAGTTTGAGGCACTAAGAAGGATATCAGTTTAAATAGAGCCCCTGTCAGAACAATATGA ATTCTGCTAAAACTGAAGCAAGAACAAACATCAAATTTATGGCAAAGCTTAGGTGGAAGAATGGTGCAATCATTGATGCTTTGCAAAAAG TTTATGGGAACAACGCCCCAAGGAAATCAGTTTACAAATGGATAATTCATTTTAAGAAAGGACAAGACAATGTTGAAGATGAAACCTACA GCAGCAGACCATGCCACTTCGTGAGGAAAAAATTATCTCATTCATGCCCTACTTGAAGAGGACCAATGATTAACAGCAGAAACGATAGCC AACACAATATGCTCCTCAGTTGGTTCAGCTTTTATAAATCTGACTGAAAAATTAAAGTTGAGCACACTTTCCACTCAATGGATACCAAAA CCATCCAGCCCAGGTCAGCTGCAGACAAAAGCAGAGCTTTCGATGGAAATGTCAAACAAGTGAGATCAAGATCCTGAAGCATTTCTTCAA AGAATTGTAGCAAAAACAGACTTTTAAAACCTTGAATTCAGAGACAGGTATAAAGACTGCTTGGTGATTTTGAAAGGACTGAGATCATTT TGGGAGAGATCATCTTCAGAAAATGACCAGATACAACAAGAATTTAACATGGCAGCCAAACCAACCCACTAACACACATTTAAATAAGAT ACCCAAATGCAGAAAGAAAAGCACAGTCGTCATGCAAAATAGTCACTACTCATTCAAAAACTCTATAGTTGTCTGAGTCGTTATGCTCAA AATATCCAATAATATTTCTTTTGCTGAGCTGTAAAATAATTATTTTGCAAACATAAAAGAAAAAAAAAAGAATTGTAACAGAAACATGGC TTTACCAGTATGACCCTCAAGACAAAATACAAAACAATGGCTACCAAGAGGTGGAAGTGGCCCAGTCACAGCAAGAGCAGATTGATCAAG AGCAAAGGTCATGGTAACAGTTTTTTGGATCCTCAAGTCATTTTGCTTGTTGACTTTTTGGAGGGCCAAATAAAGATATCATCTGCTTAT TATGAGAGTGTTTCGAGAGAAATCCAAAGCTTAGCAGAGAAACGCCTGGGAAAGCTTCACCAGAGGGTCTTCCACCGTGACAGTTCCCCT GCGCATTCCTCTCATAAAGCAAGGGCAGTTTAGCTAGAATTTCTATCAAAAATCATTAGGTATCCATCTCCCAGTCCTGATTTGGCTCCT TCTGACTTCTTTTTGTTTCCCAATCTTAAAAAAATCCCTGAAGGGCACCTGTTTTTCTTCAGCTAATAAAAAAGACATGGTTAATTTCCC AGGACCCTCAGTTCTTTAGGGATAGACTGAATGGCTGGTATCATTGCTTGAACTTAATGGAGCTTATGTTGAGAAATAAAAGAAATTATA TTTTATTTTTATCTTTTAATTCTATTTTTCCATGAACTTTTTGAAGTCCCCTCAGATATAAAGCAGAACGTTATGAAACTGAGTTACCTT GAATCTAGAAGAGTACAATGATAAAGGGGAAGATAGAAACACACACATATGCGTTGTTTTCCCCACTTTCACAATGCCGTGCAGAAACTA ACAGATGAAGGAGGAGAATCCCTAAAAACAGAGCATTGGGTAGCTAGTCCACCAGCGGTCTGATGCTTTCATTGATCTCAAAACTGTCTC TGAGTAACTCTACCAGGAAAGTTGTCTGGAGGGTTAACATTTCTGAAACCATTTTTATCTTTGCCTTCATTCTTGAATGATAATTAGTCT CGAATGTTTGGATCACAATCCATTGAAAGACTAGGCTATTTTTTCACTGTCCTCAGACATTTACTGAGTCCAGTTTGGACTTTATTTTAT TTTATTTTTTTTGAAACAAGATCTCGCTCTGTTGCTCAGGCTGAAGTGCAATAGCGCAAACTCGGCTCACTGCAACCTCCCAGGTTCAAG CAATTCTCGTGCCTCAGCCATCCCTATAGGCATGCGCCACCACACTTTGCTAATCTTGTATTTTTGGTAGAGACGGGGTTTGCACCATGT TGGCCAGGCTGGTCTCGAACTCCCAACCTCAAGTAATCTGGCCTCCCAAAGTGGTGGGATTACAGGCGTGAGCCAGCGCGCCCGGCCTGG ACTTAACTTCTGAAGAACTCTTTCTGTTTAGATTGCAGGAGCGTTCTCTCGGCTCATCTCTTGTTTTCTCACCCAGCTGTTCTTCTTCTA GTTGGCCATCATTCTTCATCCCTCCCTCCCTTTCCTGCAGTTAATTATTTCTTTGAAATTTTAAAACTTCTTAATGTTGCCTGGAATACA TGAGTCTTCCTGATCTCTTCAAACGGGGTTTGTTTTGTTTTGCTTTGGGGAGAATTCTTTTGACGTTTTTGAATAAGCTGTTAACAACTT TAATACCTGTCTTGTTTGTTTTCTTCAGAAATTTGTTAATTCTCCATGATTAGCACCTTTATGTGGTTATCTCATTATTTTCATTCCTTT TTAATTCTCTGTTTTAGGAATGCTTGTCAAATTCGTCACTAAAATTGATTTACTTTCTTGAAAACCTGTTTCTGCTGCTCCCAACATGAT TTAATCTTGGCTACTGAGCTTTTGGTTACGTTGCACTCCCTTTAAAATTACTCCGTTTAAGTACAGTGTTCACTCTTTGGGTAATGTGTA CAATAGAAGCCCAATCCCCACCTATACCCAATATATCCATGGGACAAGCATGTACATGCACCCCCTGAGTCTAAAATAAAAATTTTAAAA >In-frame_ENST00000358835_ENST00000607778_TCGA-37-4129-01A_REV3L_chr6_111688318_-_GTF2H5_chr6_158613009_length(amino acids)=2228AA_start in transcript=455_stop in transcript=7141 MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAGQKTCLHLHGIFPYLYVPYDGYGQQPESYLSQMAFSIDRALNVA LGNPSSTAQHVFKVSLVSGMPFYGYHEKERHFMKIYLYNPTMVKRICELLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAV KFRKARRKSNTLHATGSCKNHLSGNSLADTLFRWEQDEIPSSLILEGVEPQSTCELEVDAVAADILNRLDIEAQIGGNPGLQAIWEDEKQ RRRNRNETSQMSQPESQDHRFVPATESEKKFQKRLQEILKQNDFSVTLSGSVDYSDGSQEFSAELTLHSEVLSPEMLQCTPANMVEVHKD KESSKGHTRHKVEEALINEEAILNLMENSQTFQPLTQRLSESPVFMDSSPDEALVHLLAGLESDGYRGERNRMPSPCRSFGNNKYPQNSD DEENEPQIEKEEMELSLVMSQRWDSNIEEHCAKKRSLCRNTHRSSTEDDDSSSGEEMEWSDNSLLLASLSIPQLDGTADENSDNPLNNEN SRTHSSVIATSKLSVKPSIFHKDAATLEPSSSAKITFQCKHTSALSSHVLNKEDLIEDLSQTNKNTEKGLDNSVTSFTNESTYSMKYPGS LSSTVHSENSHKENSKKEILPVSSCESSIFDYEEDIPSVTRQVPSRKYTNIRKIEKDSPFIHMHRHPNENTLGKNSFNFSDLNHSKNKVS SEGNEKGNSTALSSLFPSSFTENCELLSCSGENRTMVHSLNSTADESGLNKLKIRYEEFQEHKTEKPSLSQQAAHYMFFPSVVLSNCLTR PQKLSPVTYKLQPGNKPSRLKLNKRKLAGHQETSTKSSETGSTKDNFIQNNPCNSNPEKDNALASDLTKTTRGAFENKTPTDGFIDCHFG DGTLETEQSFGLYGNKYTLRAKRKVNYETEDSESSFVTHNSKISLPHPMEIGESLDGTLKSRKRRKMSKKLPPVIIKYIIINRFRGRKNM LVKLGKIDSKEKQVILTEEKMELYKKLAPLKDFWPKVPDSPATKYPIYPLTPKKSHRRKSKHKSAKKKTGKQQRTNNENIKRTLSFRKKR SHAILSPPSPSYNAETEDCDLNYSDVMSKLGFLSERSTSPINSSPPRCWSPTDPRAEEIMAAAEKEAMLFKGPNVYKKTVNSRIGKTSRA RAQIKKSKAKLANPSIVTKKRNKRNQTNKLVDDGKKKPRAKQKTNEKGTSRKHTTLKDEKIKSQSGAEVKFVLKHQNVSEFASSSGGSQL LFKQKDMPLMGSAVDHPLSASLPTGINAQQKLSGCFSSFLESKKSVDLQTFPSSRDDLHPSVVCNSIGPGVSKINVQRPHNQSAMFTLKE STLIQKNIFDLSNHLSQVAQNTQISSGMSSKIEDNANNIQRNYLSSIGKLSEYRNSLESKLDQAYTPNFLHCKDSQQQIVCIAEQSKHSE TCSPGNTASEESQMPNNCFVTSLRSPIKQIAWEQKQRGFILDMSNFKPERVKPRSLSEAISQTKALSQCKNRNVSTPSAFGEGQSGLAVL KELLQKRQQKAQNANTTQDPLSNKHQPNKNISGSLEHNKANKRTRSVTSPRKPRTPRSTKQKEKIPKLLKVDSLNLQNSSQLDNSVSDDS PIFFSDPGFESCYSLEDSLSPEHNYNFDINTIGQTGFCSFYSGSQFVPADQNLPQKFLSDAVQDLFPGQAIEKNEFLSHDNQKCDEDKHH TTDSASWIRSGTLSPEIFEKSTIDSNENRRHNQWKNSFHPLTTRSNSIMDSFCVQQAEDCLSEKSRLNRSSVSKEVFLSLPQPNNSDWIQ GHTRKEMGQSLDSANTSFTAILSSPDGELVDVACEDLELYVSRNNDMLTPTPDSSPRSTSSPSQSKNGSFTPRTANILKPLMSPPSREEI MATLLDHDLSETIYQEPFCSNPSDVPEKPREIGGRLLMVETRLANDLAEFEGDFSLEGLRLWKTAFSAMTQNPRPGSPLRSGQGVVNKGS SNSPKMVEDKKIVIMPCKCAPSRQLVQVWLQAKEEYERSKKLPKTKPTGVVKSAENFSSSVNPDDKPVVPPKMDVSPCILPTTAHTKEDV DNSQIALQAPTTGCSQTASESQMLPPVASASDPEKDEDDDDNYYISYSSPDSPVIPPWQQPISPDSKALNGDDRPSSPVEELPSLAFENF -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for REV3L-GTF2H5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for REV3L-GTF2H5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for REV3L-GTF2H5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | REV3L | C0221060 | Mobius Syndrome | 1 | ORPHANET |
| Hgene | REV3L | C0853240 | Mobius II syndrome | 1 | ORPHANET |
| Tgene | GTF2H5 | C1955934 | Trichothiodystrophy Syndromes | 1 | ORPHANET |
| Tgene | GTF2H5 | C4017171 | TRICHOTHIODYSTROPHY 3, PHOTOSENSITIVE | 1 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
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