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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:REV3L-PDE10A (FusionGDB2 ID:73128) |
Fusion Gene Summary for REV3L-PDE10A |
Fusion gene summary |
Fusion gene information | Fusion gene name: REV3L-PDE10A | Fusion gene ID: 73128 | Hgene | Tgene | Gene symbol | REV3L | PDE10A | Gene ID | 5980 | 10846 |
Gene name | REV3 like, DNA directed polymerase zeta catalytic subunit | phosphodiesterase 10A | |
Synonyms | POLZ|REV3 | ADSD2|HSPDE10A|IOLOD|LINC00473|PDE10A19 | |
Cytomap | 6q21 | 6q27 | |
Type of gene | protein-coding | protein-coding | |
Description | DNA polymerase zeta catalytic subunitREV3-like, polymerase (DNA directed), zeta, catalytic subunitRev-3, yeast, homolog-like (polymerase, DNA, zeta) | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3',5' cAMP/cGMP phosphodiesterasedJ416F21.1 (phosphodiesterase 10A)phosphodiesterase 10A1 (PDE10A1)phosphodiesterase 10A7 (PDE10A7) | |
Modification date | 20200313 | 20200320 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000368802, ENST00000368805, ENST00000435970, ENST00000358835, ENST00000462119, | ENST00000366882, ENST00000354448, ENST00000539869, ENST00000535229, | |
Fusion gene scores | * DoF score | 17 X 20 X 10=3400 | 8 X 7 X 4=224 |
# samples | 26 | 8 | |
** MAII score | log2(26/3400*10)=-3.70895121799661 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: REV3L [Title/Abstract] AND PDE10A [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | REV3L(111803952)-PDE10A(165832265), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | REV3L-PDE10A seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. REV3L-PDE10A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. REV3L-PDE10A seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene breakpoints across REV3L (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across PDE10A (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LGG | TCGA-TM-A84B | REV3L | chr6 | 111803952 | - | PDE10A | chr6 | 165832265 | - |
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Fusion Gene ORF analysis for REV3L-PDE10A |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000368802 | ENST00000366882 | REV3L | chr6 | 111803952 | - | PDE10A | chr6 | 165832265 | - |
In-frame | ENST00000368802 | ENST00000354448 | REV3L | chr6 | 111803952 | - | PDE10A | chr6 | 165832265 | - |
In-frame | ENST00000368802 | ENST00000539869 | REV3L | chr6 | 111803952 | - | PDE10A | chr6 | 165832265 | - |
5CDS-intron | ENST00000368802 | ENST00000535229 | REV3L | chr6 | 111803952 | - | PDE10A | chr6 | 165832265 | - |
Frame-shift | ENST00000368805 | ENST00000366882 | REV3L | chr6 | 111803952 | - | PDE10A | chr6 | 165832265 | - |
Frame-shift | ENST00000368805 | ENST00000354448 | REV3L | chr6 | 111803952 | - | PDE10A | chr6 | 165832265 | - |
Frame-shift | ENST00000368805 | ENST00000539869 | REV3L | chr6 | 111803952 | - | PDE10A | chr6 | 165832265 | - |
5CDS-intron | ENST00000368805 | ENST00000535229 | REV3L | chr6 | 111803952 | - | PDE10A | chr6 | 165832265 | - |
5UTR-3CDS | ENST00000435970 | ENST00000366882 | REV3L | chr6 | 111803952 | - | PDE10A | chr6 | 165832265 | - |
5UTR-3CDS | ENST00000435970 | ENST00000354448 | REV3L | chr6 | 111803952 | - | PDE10A | chr6 | 165832265 | - |
5UTR-3CDS | ENST00000435970 | ENST00000539869 | REV3L | chr6 | 111803952 | - | PDE10A | chr6 | 165832265 | - |
5UTR-intron | ENST00000435970 | ENST00000535229 | REV3L | chr6 | 111803952 | - | PDE10A | chr6 | 165832265 | - |
Frame-shift | ENST00000358835 | ENST00000366882 | REV3L | chr6 | 111803952 | - | PDE10A | chr6 | 165832265 | - |
Frame-shift | ENST00000358835 | ENST00000354448 | REV3L | chr6 | 111803952 | - | PDE10A | chr6 | 165832265 | - |
Frame-shift | ENST00000358835 | ENST00000539869 | REV3L | chr6 | 111803952 | - | PDE10A | chr6 | 165832265 | - |
5CDS-intron | ENST00000358835 | ENST00000535229 | REV3L | chr6 | 111803952 | - | PDE10A | chr6 | 165832265 | - |
intron-3CDS | ENST00000462119 | ENST00000366882 | REV3L | chr6 | 111803952 | - | PDE10A | chr6 | 165832265 | - |
intron-3CDS | ENST00000462119 | ENST00000354448 | REV3L | chr6 | 111803952 | - | PDE10A | chr6 | 165832265 | - |
intron-3CDS | ENST00000462119 | ENST00000539869 | REV3L | chr6 | 111803952 | - | PDE10A | chr6 | 165832265 | - |
intron-intron | ENST00000462119 | ENST00000535229 | REV3L | chr6 | 111803952 | - | PDE10A | chr6 | 165832265 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000368802 | REV3L | chr6 | 111803952 | - | ENST00000366882 | PDE10A | chr6 | 165832265 | - | 7715 | 462 | 345 | 1976 | 543 |
ENST00000368802 | REV3L | chr6 | 111803952 | - | ENST00000354448 | PDE10A | chr6 | 165832265 | - | 7713 | 462 | 345 | 1976 | 543 |
ENST00000368802 | REV3L | chr6 | 111803952 | - | ENST00000539869 | PDE10A | chr6 | 165832265 | - | 3952 | 462 | 345 | 1976 | 543 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000368802 | ENST00000366882 | REV3L | chr6 | 111803952 | - | PDE10A | chr6 | 165832265 | - | 0.000193561 | 0.99980646 |
ENST00000368802 | ENST00000354448 | REV3L | chr6 | 111803952 | - | PDE10A | chr6 | 165832265 | - | 0.000192627 | 0.9998074 |
ENST00000368802 | ENST00000539869 | REV3L | chr6 | 111803952 | - | PDE10A | chr6 | 165832265 | - | 0.000421444 | 0.99957854 |
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Fusion Genomic Features for REV3L-PDE10A |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for REV3L-PDE10A |
Go to FGviewer for the breakpoints of chr6:111803952-chr6:165832265 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | PDE10A | chr6:111803952 | chr6:165832265 | ENST00000354448 | 9 | 22 | 442_759 | 275.0 | 780.0 | Domain | PDEase | |
Tgene | PDE10A | chr6:111803952 | chr6:165832265 | ENST00000366882 | 10 | 23 | 442_759 | 275.0 | 780.0 | Domain | PDEase | |
Tgene | PDE10A | chr6:111803952 | chr6:165832265 | ENST00000539869 | 9 | 22 | 442_759 | 285.0 | 790.0 | Domain | PDEase | |
Tgene | PDE10A | chr6:111803952 | chr6:165832265 | ENST00000354448 | 9 | 22 | 286_287 | 275.0 | 780.0 | Region | 3'%2C5'-cAMP binding | |
Tgene | PDE10A | chr6:111803952 | chr6:165832265 | ENST00000354448 | 9 | 22 | 330_331 | 275.0 | 780.0 | Region | 3'%2C5'-cAMP binding | |
Tgene | PDE10A | chr6:111803952 | chr6:165832265 | ENST00000366882 | 10 | 23 | 286_287 | 275.0 | 780.0 | Region | 3'%2C5'-cAMP binding | |
Tgene | PDE10A | chr6:111803952 | chr6:165832265 | ENST00000366882 | 10 | 23 | 330_331 | 275.0 | 780.0 | Region | 3'%2C5'-cAMP binding | |
Tgene | PDE10A | chr6:111803952 | chr6:165832265 | ENST00000539869 | 9 | 22 | 286_287 | 285.0 | 790.0 | Region | 3'%2C5'-cAMP binding | |
Tgene | PDE10A | chr6:111803952 | chr6:165832265 | ENST00000539869 | 9 | 22 | 330_331 | 285.0 | 790.0 | Region | 3'%2C5'-cAMP binding |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | REV3L | chr6:111803952 | chr6:165832265 | ENST00000358835 | - | 2 | 33 | 3086_3104 | 46.333333333333336 | 3131.0 | Motif | Note=CysB motif |
Hgene | REV3L | chr6:111803952 | chr6:165832265 | ENST00000368802 | - | 1 | 32 | 3086_3104 | 46.333333333333336 | 3131.0 | Motif | Note=CysB motif |
Hgene | REV3L | chr6:111803952 | chr6:165832265 | ENST00000368805 | - | 2 | 33 | 3086_3104 | 46.333333333333336 | 3131.0 | Motif | Note=CysB motif |
Hgene | REV3L | chr6:111803952 | chr6:165832265 | ENST00000435970 | - | 2 | 34 | 3086_3104 | 0 | 3053.0 | Motif | Note=CysB motif |
Hgene | REV3L | chr6:111803952 | chr6:165832265 | ENST00000358835 | - | 2 | 33 | 3042_3057 | 46.333333333333336 | 3131.0 | Zinc finger | Note=CysA-type |
Hgene | REV3L | chr6:111803952 | chr6:165832265 | ENST00000368802 | - | 1 | 32 | 3042_3057 | 46.333333333333336 | 3131.0 | Zinc finger | Note=CysA-type |
Hgene | REV3L | chr6:111803952 | chr6:165832265 | ENST00000368805 | - | 2 | 33 | 3042_3057 | 46.333333333333336 | 3131.0 | Zinc finger | Note=CysA-type |
Hgene | REV3L | chr6:111803952 | chr6:165832265 | ENST00000435970 | - | 2 | 34 | 3042_3057 | 0 | 3053.0 | Zinc finger | Note=CysA-type |
Tgene | PDE10A | chr6:111803952 | chr6:165832265 | ENST00000354448 | 9 | 22 | 266_412 | 275.0 | 780.0 | Domain | Note=GAF 2 | |
Tgene | PDE10A | chr6:111803952 | chr6:165832265 | ENST00000354448 | 9 | 22 | 91_234 | 275.0 | 780.0 | Domain | Note=GAF 1 | |
Tgene | PDE10A | chr6:111803952 | chr6:165832265 | ENST00000366882 | 10 | 23 | 266_412 | 275.0 | 780.0 | Domain | Note=GAF 2 | |
Tgene | PDE10A | chr6:111803952 | chr6:165832265 | ENST00000366882 | 10 | 23 | 91_234 | 275.0 | 780.0 | Domain | Note=GAF 1 | |
Tgene | PDE10A | chr6:111803952 | chr6:165832265 | ENST00000539869 | 9 | 22 | 266_412 | 285.0 | 790.0 | Domain | Note=GAF 2 | |
Tgene | PDE10A | chr6:111803952 | chr6:165832265 | ENST00000539869 | 9 | 22 | 91_234 | 285.0 | 790.0 | Domain | Note=GAF 1 |
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Fusion Gene Sequence for REV3L-PDE10A |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000368802_ENST00000366882_TCGA-TM-A84B_REV3L_chr6_111803952_-_PDE10A_chr6_165832265_length(transcript)=7715nt_BP=462nt CATCATCATGGCAACAAGAGCTGCAGCCTGGGACCGAGGAGCCCGTGTGATTCCCGGCGGTGGCGGCAGTGGCGGCAGCACCAGCACCGA CGAAAGCTCGAGGGCTTCTCTCCTGCGGCCCCTTGCCGGGTGCTCCTGAGGAGGCGGCGGCAGCAGCGCCTACACCGCCCCGCCCGCCGC TCCTCGAGGTGCCTCTGTGTGAGGGGAGGGGGCCGTGCCGAGAAGGGGAGGGGGCGCCGCCGCCGCTGCGGAGGGAGCCGCCGCCGCTGC TGCTGCCGCTGCCGGGTCGCCAGTGAAGGGAGGCAGTGGCGGCGGCGGCGAACATGTTTTCAGTAAGGATAGTGACTGCAGACTACTACA TGGCCAGCCCGCTGCAGGGGCTGGATACCTGCCAATCCCCCCTCACCCAGGCCCCTGTCAAGAAGGTGCCGGTGGTGCGAGTCTTCGGAG CGACCCCGGCAGATATATGCAAAAAACCTGGTGAATGCCGATCGTTGTGCGCTTTTCCAGGTGGACCATAAGAACAAGGAGTTATATTCA GACCTTTTTGATATTGGAGAGGAAAAGGAAGGAAAACCTGTCTTCAAGAAGACCAAAGAGATAAGATTTTCAATTGAGAAAGGAATTGCT GGCCAAGTAGCAAGAACAGGGGAAGTCCTGAACATTCCAGATGCCTATGCAGACCCACGCTTTAACAGAGAAGTAGACTTGTACACAGGC TACACCACGCGGAACATCCTGTGCATGCCCATCGTCAGCCGAGGCAGCGTGATAGGTGTGGTGCAGATGGTCAACAAAATCAGTGGCAGT GCCTTCTCTAAAACAGATGAAAACAACTTCAAAATGTTTGCCGTCTTTTGTGCTTTAGCCTTACACTGTGCTAATATGTATCATAGAATT CGCCACTCAGAGTGCATTTACCGGGTAACGATGGAAAAGCTGTCCTACCATAGCATTTGTACTTCAGAAGAGTGGCAAGGTCTCATGCAA TTCACCCTTCCCGTGCGTCTCTGCAAAGAAATTGAATTATTCCACTTTGACATTGGTCCTTTTGAAAACATGTGGCCTGGAATTTTTGTC TACATGGTTCATCGGTCCTGTGGGACATCCTGCTTTGAGCTTGAAAAGTTGTGTCGTTTTATTATGTCTGTGAAGAAGAACTATCGGCGG GTTCCTTATCACAACTGGAAGCATGCGGTCACTGTAGCACACTGCATGTATGCCATACTTCAGAACAATCACACGCTTTTCACAGACCTT GAGCGCAAAGGACTGCTGATTGCGTGTCTGTGTCATGACCTGGACCACAGGGGCTTCAGTAACAGCTACCTGCAGAAGTTCGACCACCCT CTGGCCGCTCTCTACTCCACTTCCACCATGGAGCAGCACCACTTCTCCCAGACTGTGTCCATCCTCCAGTTGGAAGGGCACAATATCTTC TCCACTCTGAGCTCCAGTGAATATGAGCAGGTGCTTGAGATCATCCGCAAAGCCATCATTGCCACAGACCTTGCTTTATACTTTGGAAAC AGGAAGCAGTTGGAAGAGATGTACCAGACCGGATCACTAAACCTTAATAATCAATCACATAGAGACCGTGTAATTGGTTTGATGATGACT GCCTGTGACCTTTGTTCTGTGACAAAACTGTGGCCCGTTACAAAATTGACGGCAAATGATATATATGCAGAATTCTGGGCTGAGGGTGAT GAAATGAAGAAATTGGGAATACAGCCTATTCCTATGATGGACAGAGACAAGAAGGATGAAGTCCCCCAAGGCCAGCTTGGGTTCTACAAT GCCGTGGCCATTCCCTGCTATACAACCCTTACCCAGATCCTCCCTCCCACGGAGCCTCTTCTGAAAGCATGCAGGGATAATCTCAGTCAG TGGGAGAAGGTGATTCGAGGGGAGGAGACTGCAACCTGGATTTCATCCCCATCCGTGGCTCAGAAGGCAGCTGCATCTGAAGATTGAGCA CTGGTCACCCTGACACGCTGTCCCACCTACAGATCCTCATCTTGCTTCTTTGACATTCTTTTCCTTTTTTTGGGGGGGGTGGGGGGAACC TGCACCTGGTAACTGGGGTGCAAACCTCTTCAAGAAGGTAACATCAAATAAATAAGTCAAGCAGAGGACTTCCTGCCAATCTCTTCTGTG AGGCATCATAGACACTGAGCAACCAGGACCACCCCCACGTTCAGAAATCAGCTGGCCAAGTGACTCCATTTGACTTGCAAACCAGCCTTT TCTAATAGGCTAATATTGCTGAGGCCTTAAAGGAAATGGACAAAAATTATCCAGAAGGGGTACTTTTCCATTGTATCTTTCTAATAAGGG TTTAAAATGGTACTATTATGGTATTGTACTTGGGCTTTAACATCAATGTTGCTTTGATGTTGTTGGATATAAATAGGAATTTTTACACAT TACTATTGTGAATGGTGAATGTTCATGTATGACCTACTTGTAATTAACTTGAGTTGTAGTCCACAGCCTCAGGACAAATGTCGTTGAGGT TACAGAGTAAGAAATGATGGCAAAACGTCAAACTCTTATTTCAGAGCTTCATGAATTTAGTTAGACTAAACATAATTCTTTAAGTTCAAC CTAAAGGGCTGAGATCAATAAATTTAACACTAGACGAAGTAGACTTCCTGTCTTTTTGAGAAGAGATGAGGTATATGTTACAATAAATCT CAGAACTTCAAGTAGCAGTTCAAAAGATGTCAGTTTTTAAAATTGTTTTTGTTGTTGTCTTGGCAGTTTTACTGAACCCTTTGCATAAAG AACAAAATAAAAGCTCGGCATTGTAATTTTTTTAATGGACAAGTCTTATGGATACGAAGGGTACATTTTTCATAATGATTCCTTTATATT TTCACTTTGTGTCATTGCAGAATTTTAGACTCTCATTCACAATGAAAAGTTTATTTTAAACATTGTTTAATTAAAATACCATACAGTTCT CTTTTAAACATCAAACCATAAAAAGTGTATTTTGTAATTTTACTCTGACCTGCCGCAGTCACCTCTCACTTATCTCTTCCACGTACTGCA CGGTCGTATTTCATGAGCTTTCTGTCCATAGCACAGAAACAGAGCAGAAAGTAGTACAATCATGTTGGACCTTCTTTCTGTTCTCTTTAC TCTTCTCACAGATCAGATCACTCCATAGAAGCCTGTGGGTTTCGATGGTTTCTTCTATACACCTTTTTGGTTGACCAGTATTACTATACA ATGTAAGTGTTTTAAAAAATACGAAAGTAATACTCTGCACCCCTTCCTACAAAGATGATAAAGCAGTCACTTCTGGCGCATTTTAATAAT TTAAAGATTTTTAGTGCAATGGCACGGTAACCTCCAAACCTGAATTAGACAGAGACTCACTCAGGAAGTGACAGGCCCATCATATCAAAT AACTTATTCACTTTTCATGTGGCAGGAAACTGGAATATCGCTTTTAATAAAATGGAAAAATATGCTTCTACATATTTACCACCATAGGCG TTTTGTTCATATGAGCCTGGTTTGTGCAAAATTAAATCAGAGGCTTCTACAACATGGTTTATTTATGTTGTAGCAAAGTTGGCTCTACAT AAACATTGTTCTTATTTTAAAATTAACACTATGTGTTCAGTTTTCTTGTGGGCTTCTGAAAGTTGCCATCTTCCCTCCGTGGAGCTCCAT TTGCTATTTTCATTATACACTATGAGGTAAAATGTAATAACAAAAGAGAGAGAAGTACCACTGTGGCTAGATATATACACACACATATAT ATATGGATGGATGTAATATATGTAGAACACACACATAGATGTATATAGGATACACACTCATGTATGTAAACGTATACATATGTGTATATA TGATACATACACATACACACACACGAGAGACAGAAGGAAAGAGAGGAAGAGAGAAGCAAACATGTAGGAAAAAATATAAATCAGCCCCAT TCTCCCATTCTTTAAGAACAATGATTTTTCTTGATGGAAAATGCATATCACTTGACAGTTGACAAGAAAGTGTCATTTTTGTGTTAGTGT ATCATATAATTGAATTTGAACAAGATACATATTTTTCTGCATACAAATTTATGAAGCTGGAGTCTACCAAACACAGCTTTAGTCACAAAA GTTAGTTTAGTTATCTCATTTCGCTTGGAGATGGAATTTCAGGAAGGGATATATTATTTAAGATTATTGTTTAATTACAAGAATTTTAAA AGAATGTATGAATTCTGTTTTTTAATATAGAAAATAATTATGGAGTTAGGAATCTCATGGCTACATTTACATTTTTAGGTTATTACAGAA AATTCTCTTAATTTATTATAGTCAAGTGTATTATGTAATCTCTATTTAGAACAGTTTCCCAAAGGAATGTGATTGGATTTACTGGTTGGT TAATTTCTTGTGAAATATTGTCATAATAGAAGCACAGCTTGAACAAAAGACTGAATTCTGATATAAACTGTCAATATTGCTTTTACCATG TGTAAGATTTACTTAGTAATCACAGATTTACCTAAAATAAAAGGACCCGGGTTGCAGTGATATTTAGTTAATGATTTGTTTTGGAAAACA TGCAGTTAGGAGTATTTTTGTATTTTGTCAGATGTTTAGGAGACAGACTTTCGGGTCATGTTTCTTGTCTTGTTCCCAGATCTTTTCTTA AAAGAACAGTGTGACACCAGAAGCCAAGAGATGGTTTTTACTAACAACAGCTTTGATGAGTTCCTATTAAGGTCGTATTGTGTATTGTGC CAAATTTTCCACCCAGTATAAATTTAGTAACCCGCTATGAGCATATGTAGGATATTCAATTTGCAGATACTTTTGTTGGTTATGTTGGTT TATAATAGACAAGTTTTATGGTCATATGCAATTATTCCATTATCTTTTTGGACACAGTGAATATGTTTTTTAGCTAAAAATGTCCTTGGA AACATAAATGCCTGCCAATAACATGGAATATTGAATTCGGGCAATGTGAATTGATTAATTAGAAAAGGGTCAAAAGAAATACAATGGATG TGGAAACTAATTCTAAAAAATAGCCCTATTAATAGGGCAGAGACTCTGGTCCATTTCCCAGCTGTACTTCTCTCTAAGAGGTGTATGAAA AACCCATCTTGCAAAAGAGACCAAAATATTAGACACAATCGTTCCCATTCCTGACTCTTCAATGGAAAAGGAAGGTACAGATGTTTACAG TGGTGCCCCAGGTGACTCGTTCTCACCACAACAAAAGCAACTAATTGGAAACTAGATGTGTTCAATAATAGATTTCCTCTTTTTTGGCAT GCTTTTTAGATTTTTTTTCATTTTGTAAAATCTCAGTTAATTTTTCTTTATTGGTATATTTGTGTATGCGAGACAAATCCTGTATTGTAC AGGATATAAATAGATGCATAAATCCTTAGATACCTGGGTTTTTTAATAGGTTTAGGTTTGGGTATTGTGTTTCTGGTCTTTTAACTCAAA ATTAAGGTTTGAGCTTTAATAGGACTAAATTATTCACCTGCCTTGGCCTGTGCCTTTATTTTAAATACTGCAATTTTACTTCTTCATTCA TGTATTTATTATTTTGCTTTTCTTGCTTAAGTATAATTGAAAATATTTGCAGGAACGCACAATTCATTTTATCAAGTTGAATGAATAGGA CCATTCTCTCCTCATCAGATTTCTGTTCTTTATTTGACTTCATTGACATATACCCTGGTGACTATAACCAGTGAACTGTTCAGAGTCAGT CTTTTCGGCAAGAACTTCAGAGAACTGTGACACTGGTTATGATGTGATTTTGGGGGGTTTCAGGTACCTAAGCATGATTTTTAAAATCAC TTCTCTCTTTACATATTTCGAACATATGTTTGCTTTCTACACTTTGCAGATTTTATTTAGGATTTAATTCTTTAAAGACTATATTCATTT AGTCACTATAGTGGATCTCTTCTACTGCAAGTATTCATCTGATTTTTAAATTATGTAAAATGTAAATCAGCCAAGTATGTCATCCGTTAT AGTTTCCCCATGCTTTCAGCGCATGGCCATGAGATTTTTACATGTGCATAAGTATTTAGCCAATACACATTTTGCTGACTTCTTTAACCA TTTATATTGTTTAAATTAGTAATATCCAATGCAGTGCACACTTTTTTGTCTTTTTTCCAACGGAATATTTTGGTTGTCTGTAGCGTTGGA AGCATTTTATATGATAAAAATAGCAAGAAAAAATTAAAAAGTGTCAACGGTGTGCTGGTTCTAAATTAAGAAGATAGAACAAAGAGAAAG ACATTAATGTTACCTAAGAAACACATTTAACATCCGAAGAAGCAATGCTGTCCTCACTTGATGTTTCTCTTCTCAACCCAGCAATGGAGA GCAGGGCTTGCAAAGCCGTACAGAGCCTACGTGCTCTTTCCTGCAAGTGGGAGAAAACTAATCAATGGCACACAGGGCCAGGTGTGGCCC TGTGAGGCAAAGGATAATGTCACCTCAGGACCAAGGTGGAAACTTACAGCTGAATCCAGGGCTTACTAAGTAGGGAAGTCAGTTTACATA TTTCAGTTTTCCTCTGATGTTTTTGAGGTACTGTGTATTTGCAGAAGTTTAAGCAGAAGGGTTTTGTTTCTATTGTAAGTTAGGTTCTAA AAGTGTATAATCTGATACTCTAGCCCAACTGAAATATTATATCTTGGGCGTTACAGCCTTTGTCTTTTTCTTTAGTCACCTTAATACCCA GTCCTATGCTGTATCTCTGATAGCCTATATAAATGACATATAGGAATATTATTTTCCATATGATCTGTTGTATGGTGTATATGCTATGTG TTCATTTCGTGTGCAAGTTCAGAGTGTAATAGATTTACCCAGAGAAGGTGTTTCTATACAATGCCCCTACCTATTTGAAATTACATGCTT GCCCAACACACTGTGAAATAGTTACCAAAATTTGTACAAATGCAGCATCTTCATTCTTTCTGAGAAGACAAGATGGTTTTCTTTACATGA ACAAATGAACAAAAGAGATCCTAGATCCATAACGTAGCTAAGGCATCTAAGAGTTTGCTGTTGATAATCTTGCTGACCAAAAACTACTGG AGAGTAACACAGGTTATATGCCATCACAAATACAATGCTCATGAAGAACTGATTTGTAGAGTCAATGAACCTGTGTCCAGAATTTTAATA GGCTCTCTATTGGAAGGAGAAAGAATTTCAAGTTAACAGTATCTAACTTTATCATAGTTGATGTTAGTAAATTTTAAAAAATGATTTTAT ATGTATGACAAAAATCTTTGTAAAATGCGCAAGTGCAATAATTTAAAGAGGTCTTAACTTTGCATTTATAAATTATAAATATTGTACATG TGTGTAATTTTTTCATGTATTCATTTGCAGTCTTTGTATTTAAAAAACATTTACTGTTATGTTTGTATAATAGAACAGTAATCATTTATT ATAATCTAGGCAAGTTGTAAATAAATTCATAATTCAAACAGCCAGTATATATGCATATATGAGTGTTATATTGCAAAATCTTTGTTTTAC TTACATGGTTAAAGCAGCAAGAATTCTTTTGTTGATATGTAATTATACACATAAAATATATATATGTATGATACATGAAATATATTTAGA >In-frame_ENST00000368802_ENST00000366882_TCGA-TM-A84B_REV3L_chr6_111803952_-_PDE10A_chr6_165832265_length(amino acids)=543AA_start in transcript=345_stop in transcript=1976 MQTTTWPARCRGWIPANPPSPRPLSRRCRWCESSERPRQIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSI EKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCAN MYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVK KNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLE GHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEF WAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAA -------------------------------------------------------------- >In-frame_ENST00000368802_ENST00000354448_TCGA-TM-A84B_REV3L_chr6_111803952_-_PDE10A_chr6_165832265_length(transcript)=7713nt_BP=462nt CATCATCATGGCAACAAGAGCTGCAGCCTGGGACCGAGGAGCCCGTGTGATTCCCGGCGGTGGCGGCAGTGGCGGCAGCACCAGCACCGA CGAAAGCTCGAGGGCTTCTCTCCTGCGGCCCCTTGCCGGGTGCTCCTGAGGAGGCGGCGGCAGCAGCGCCTACACCGCCCCGCCCGCCGC TCCTCGAGGTGCCTCTGTGTGAGGGGAGGGGGCCGTGCCGAGAAGGGGAGGGGGCGCCGCCGCCGCTGCGGAGGGAGCCGCCGCCGCTGC TGCTGCCGCTGCCGGGTCGCCAGTGAAGGGAGGCAGTGGCGGCGGCGGCGAACATGTTTTCAGTAAGGATAGTGACTGCAGACTACTACA TGGCCAGCCCGCTGCAGGGGCTGGATACCTGCCAATCCCCCCTCACCCAGGCCCCTGTCAAGAAGGTGCCGGTGGTGCGAGTCTTCGGAG CGACCCCGGCAGATATATGCAAAAAACCTGGTGAATGCCGATCGTTGTGCGCTTTTCCAGGTGGACCATAAGAACAAGGAGTTATATTCA GACCTTTTTGATATTGGAGAGGAAAAGGAAGGAAAACCTGTCTTCAAGAAGACCAAAGAGATAAGATTTTCAATTGAGAAAGGAATTGCT GGCCAAGTAGCAAGAACAGGGGAAGTCCTGAACATTCCAGATGCCTATGCAGACCCACGCTTTAACAGAGAAGTAGACTTGTACACAGGC TACACCACGCGGAACATCCTGTGCATGCCCATCGTCAGCCGAGGCAGCGTGATAGGTGTGGTGCAGATGGTCAACAAAATCAGTGGCAGT GCCTTCTCTAAAACAGATGAAAACAACTTCAAAATGTTTGCCGTCTTTTGTGCTTTAGCCTTACACTGTGCTAATATGTATCATAGAATT CGCCACTCAGAGTGCATTTACCGGGTAACGATGGAAAAGCTGTCCTACCATAGCATTTGTACTTCAGAAGAGTGGCAAGGTCTCATGCAA TTCACCCTTCCCGTGCGTCTCTGCAAAGAAATTGAATTATTCCACTTTGACATTGGTCCTTTTGAAAACATGTGGCCTGGAATTTTTGTC TACATGGTTCATCGGTCCTGTGGGACATCCTGCTTTGAGCTTGAAAAGTTGTGTCGTTTTATTATGTCTGTGAAGAAGAACTATCGGCGG GTTCCTTATCACAACTGGAAGCATGCGGTCACTGTAGCACACTGCATGTATGCCATACTTCAGAACAATCACACGCTTTTCACAGACCTT GAGCGCAAAGGACTGCTGATTGCGTGTCTGTGTCATGACCTGGACCACAGGGGCTTCAGTAACAGCTACCTGCAGAAGTTCGACCACCCT CTGGCCGCTCTCTACTCCACTTCCACCATGGAGCAGCACCACTTCTCCCAGACTGTGTCCATCCTCCAGTTGGAAGGGCACAATATCTTC TCCACTCTGAGCTCCAGTGAATATGAGCAGGTGCTTGAGATCATCCGCAAAGCCATCATTGCCACAGACCTTGCTTTATACTTTGGAAAC AGGAAGCAGTTGGAAGAGATGTACCAGACCGGATCACTAAACCTTAATAATCAATCACATAGAGACCGTGTAATTGGTTTGATGATGACT GCCTGTGACCTTTGTTCTGTGACAAAACTGTGGCCCGTTACAAAATTGACGGCAAATGATATATATGCAGAATTCTGGGCTGAGGGTGAT GAAATGAAGAAATTGGGAATACAGCCTATTCCTATGATGGACAGAGACAAGAAGGATGAAGTCCCCCAAGGCCAGCTTGGGTTCTACAAT GCCGTGGCCATTCCCTGCTATACAACCCTTACCCAGATCCTCCCTCCCACGGAGCCTCTTCTGAAAGCATGCAGGGATAATCTCAGTCAG TGGGAGAAGGTGATTCGAGGGGAGGAGACTGCAACCTGGATTTCATCCCCATCCGTGGCTCAGAAGGCAGCTGCATCTGAAGATTGAGCA CTGGTCACCCTGACACGCTGTCCCACCTACAGATCCTCATCTTGCTTCTTTGACATTCTTTTCCTTTTTTTGGGGGGGGTGGGGGGAACC TGCACCTGGTAACTGGGGTGCAAACCTCTTCAAGAAGGTAACATCAAATAAATAAGTCAAGCAGAGGACTTCCTGCCAATCTCTTCTGTG AGGCATCATAGACACTGAGCAACCAGGACCACCCCCACGTTCAGAAATCAGCTGGCCAAGTGACTCCATTTGACTTGCAAACCAGCCTTT TCTAATAGGCTAATATTGCTGAGGCCTTAAAGGAAATGGACAAAAATTATCCAGAAGGGGTACTTTTCCATTGTATCTTTCTAATAAGGG TTTAAAATGGTACTATTATGGTATTGTACTTGGGCTTTAACATCAATGTTGCTTTGATGTTGTTGGATATAAATAGGAATTTTTACACAT TACTATTGTGAATGGTGAATGTTCATGTATGACCTACTTGTAATTAACTTGAGTTGTAGTCCACAGCCTCAGGACAAATGTCGTTGAGGT TACAGAGTAAGAAATGATGGCAAAACGTCAAACTCTTATTTCAGAGCTTCATGAATTTAGTTAGACTAAACATAATTCTTTAAGTTCAAC CTAAAGGGCTGAGATCAATAAATTTAACACTAGACGAAGTAGACTTCCTGTCTTTTTGAGAAGAGATGAGGTATATGTTACAATAAATCT CAGAACTTCAAGTAGCAGTTCAAAAGATGTCAGTTTTTAAAATTGTTTTTGTTGTTGTCTTGGCAGTTTTACTGAACCCTTTGCATAAAG AACAAAATAAAAGCTCGGCATTGTAATTTTTTTAATGGACAAGTCTTATGGATACGAAGGGTACATTTTTCATAATGATTCCTTTATATT TTCACTTTGTGTCATTGCAGAATTTTAGACTCTCATTCACAATGAAAAGTTTATTTTAAACATTGTTTAATTAAAATACCATACAGTTCT CTTTTAAACATCAAACCATAAAAAGTGTATTTTGTAATTTTACTCTGACCTGCCGCAGTCACCTCTCACTTATCTCTTCCACGTACTGCA CGGTCGTATTTCATGAGCTTTCTGTCCATAGCACAGAAACAGAGCAGAAAGTAGTACAATCATGTTGGACCTTCTTTCTGTTCTCTTTAC TCTTCTCACAGATCAGATCACTCCATAGAAGCCTGTGGGTTTCGATGGTTTCTTCTATACACCTTTTTGGTTGACCAGTATTACTATACA ATGTAAGTGTTTTAAAAAATACGAAAGTAATACTCTGCACCCCTTCCTACAAAGATGATAAAGCAGTCACTTCTGGCGCATTTTAATAAT TTAAAGATTTTTAGTGCAATGGCACGGTAACCTCCAAACCTGAATTAGACAGAGACTCACTCAGGAAGTGACAGGCCCATCATATCAAAT AACTTATTCACTTTTCATGTGGCAGGAAACTGGAATATCGCTTTTAATAAAATGGAAAAATATGCTTCTACATATTTACCACCATAGGCG TTTTGTTCATATGAGCCTGGTTTGTGCAAAATTAAATCAGAGGCTTCTACAACATGGTTTATTTATGTTGTAGCAAAGTTGGCTCTACAT AAACATTGTTCTTATTTTAAAATTAACACTATGTGTTCAGTTTTCTTGTGGGCTTCTGAAAGTTGCCATCTTCCCTCCGTGGAGCTCCAT TTGCTATTTTCATTATACACTATGAGGTAAAATGTAATAACAAAAGAGAGAGAAGTACCACTGTGGCTAGATATATACACACACATATAT ATATGGATGGATGTAATATATGTAGAACACACACATAGATGTATATAGGATACACACTCATGTATGTAAACGTATACATATGTGTATATA TGATACATACACATACACACACACGAGAGACAGAAGGAAAGAGAGGAAGAGAGAAGCAAACATGTAGGAAAAAATATAAATCAGCCCCAT TCTCCCATTCTTTAAGAACAATGATTTTTCTTGATGGAAAATGCATATCACTTGACAGTTGACAAGAAAGTGTCATTTTTGTGTTAGTGT ATCATATAATTGAATTTGAACAAGATACATATTTTTCTGCATACAAATTTATGAAGCTGGAGTCTACCAAACACAGCTTTAGTCACAAAA GTTAGTTTAGTTATCTCATTTCGCTTGGAGATGGAATTTCAGGAAGGGATATATTATTTAAGATTATTGTTTAATTACAAGAATTTTAAA AGAATGTATGAATTCTGTTTTTTAATATAGAAAATAATTATGGAGTTAGGAATCTCATGGCTACATTTACATTTTTAGGTTATTACAGAA AATTCTCTTAATTTATTATAGTCAAGTGTATTATGTAATCTCTATTTAGAACAGTTTCCCAAAGGAATGTGATTGGATTTACTGGTTGGT TAATTTCTTGTGAAATATTGTCATAATAGAAGCACAGCTTGAACAAAAGACTGAATTCTGATATAAACTGTCAATATTGCTTTTACCATG TGTAAGATTTACTTAGTAATCACAGATTTACCTAAAATAAAAGGACCCGGGTTGCAGTGATATTTAGTTAATGATTTGTTTTGGAAAACA TGCAGTTAGGAGTATTTTTGTATTTTGTCAGATGTTTAGGAGACAGACTTTCGGGTCATGTTTCTTGTCTTGTTCCCAGATCTTTTCTTA AAAGAACAGTGTGACACCAGAAGCCAAGAGATGGTTTTTACTAACAACAGCTTTGATGAGTTCCTATTAAGGTCGTATTGTGTATTGTGC CAAATTTTCCACCCAGTATAAATTTAGTAACCCGCTATGAGCATATGTAGGATATTCAATTTGCAGATACTTTTGTTGGTTATGTTGGTT TATAATAGACAAGTTTTATGGTCATATGCAATTATTCCATTATCTTTTTGGACACAGTGAATATGTTTTTTAGCTAAAAATGTCCTTGGA AACATAAATGCCTGCCAATAACATGGAATATTGAATTCGGGCAATGTGAATTGATTAATTAGAAAAGGGTCAAAAGAAATACAATGGATG TGGAAACTAATTCTAAAAAATAGCCCTATTAATAGGGCAGAGACTCTGGTCCATTTCCCAGCTGTACTTCTCTCTAAGAGGTGTATGAAA AACCCATCTTGCAAAAGAGACCAAAATATTAGACACAATCGTTCCCATTCCTGACTCTTCAATGGAAAAGGAAGGTACAGATGTTTACAG TGGTGCCCCAGGTGACTCGTTCTCACCACAACAAAAGCAACTAATTGGAAACTAGATGTGTTCAATAATAGATTTCCTCTTTTTTGGCAT GCTTTTTAGATTTTTTTTCATTTTGTAAAATCTCAGTTAATTTTTCTTTATTGGTATATTTGTGTATGCGAGACAAATCCTGTATTGTAC AGGATATAAATAGATGCATAAATCCTTAGATACCTGGGTTTTTTAATAGGTTTAGGTTTGGGTATTGTGTTTCTGGTCTTTTAACTCAAA ATTAAGGTTTGAGCTTTAATAGGACTAAATTATTCACCTGCCTTGGCCTGTGCCTTTATTTTAAATACTGCAATTTTACTTCTTCATTCA TGTATTTATTATTTTGCTTTTCTTGCTTAAGTATAATTGAAAATATTTGCAGGAACGCACAATTCATTTTATCAAGTTGAATGAATAGGA CCATTCTCTCCTCATCAGATTTCTGTTCTTTATTTGACTTCATTGACATATACCCTGGTGACTATAACCAGTGAACTGTTCAGAGTCAGT CTTTTCGGCAAGAACTTCAGAGAACTGTGACACTGGTTATGATGTGATTTTGGGGGGTTTCAGGTACCTAAGCATGATTTTTAAAATCAC TTCTCTCTTTACATATTTCGAACATATGTTTGCTTTCTACACTTTGCAGATTTTATTTAGGATTTAATTCTTTAAAGACTATATTCATTT AGTCACTATAGTGGATCTCTTCTACTGCAAGTATTCATCTGATTTTTAAATTATGTAAAATGTAAATCAGCCAAGTATGTCATCCGTTAT AGTTTCCCCATGCTTTCAGCGCATGGCCATGAGATTTTTACATGTGCATAAGTATTTAGCCAATACACATTTTGCTGACTTCTTTAACCA TTTATATTGTTTAAATTAGTAATATCCAATGCAGTGCACACTTTTTTGTCTTTTTTCCAACGGAATATTTTGGTTGTCTGTAGCGTTGGA AGCATTTTATATGATAAAAATAGCAAGAAAAAATTAAAAAGTGTCAACGGTGTGCTGGTTCTAAATTAAGAAGATAGAACAAAGAGAAAG ACATTAATGTTACCTAAGAAACACATTTAACATCCGAAGAAGCAATGCTGTCCTCACTTGATGTTTCTCTTCTCAACCCAGCAATGGAGA GCAGGGCTTGCAAAGCCGTACAGAGCCTACGTGCTCTTTCCTGCAAGTGGGAGAAAACTAATCAATGGCACACAGGGCCAGGTGTGGCCC TGTGAGGCAAAGGATAATGTCACCTCAGGACCAAGGTGGAAACTTACAGCTGAATCCAGGGCTTACTAAGTAGGGAAGTCAGTTTACATA TTTCAGTTTTCCTCTGATGTTTTTGAGGTACTGTGTATTTGCAGAAGTTTAAGCAGAAGGGTTTTGTTTCTATTGTAAGTTAGGTTCTAA AAGTGTATAATCTGATACTCTAGCCCAACTGAAATATTATATCTTGGGCGTTACAGCCTTTGTCTTTTTCTTTAGTCACCTTAATACCCA GTCCTATGCTGTATCTCTGATAGCCTATATAAATGACATATAGGAATATTATTTTCCATATGATCTGTTGTATGGTGTATATGCTATGTG TTCATTTCGTGTGCAAGTTCAGAGTGTAATAGATTTACCCAGAGAAGGTGTTTCTATACAATGCCCCTACCTATTTGAAATTACATGCTT GCCCAACACACTGTGAAATAGTTACCAAAATTTGTACAAATGCAGCATCTTCATTCTTTCTGAGAAGACAAGATGGTTTTCTTTACATGA ACAAATGAACAAAAGAGATCCTAGATCCATAACGTAGCTAAGGCATCTAAGAGTTTGCTGTTGATAATCTTGCTGACCAAAAACTACTGG AGAGTAACACAGGTTATATGCCATCACAAATACAATGCTCATGAAGAACTGATTTGTAGAGTCAATGAACCTGTGTCCAGAATTTTAATA GGCTCTCTATTGGAAGGAGAAAGAATTTCAAGTTAACAGTATCTAACTTTATCATAGTTGATGTTAGTAAATTTTAAAAAATGATTTTAT ATGTATGACAAAAATCTTTGTAAAATGCGCAAGTGCAATAATTTAAAGAGGTCTTAACTTTGCATTTATAAATTATAAATATTGTACATG TGTGTAATTTTTTCATGTATTCATTTGCAGTCTTTGTATTTAAAAAACATTTACTGTTATGTTTGTATAATAGAACAGTAATCATTTATT ATAATCTAGGCAAGTTGTAAATAAATTCATAATTCAAACAGCCAGTATATATGCATATATGAGTGTTATATTGCAAAATCTTTGTTTTAC TTACATGGTTAAAGCAGCAAGAATTCTTTTGTTGATATGTAATTATACACATAAAATATATATATGTATGATACATGAAATATATTTAGA >In-frame_ENST00000368802_ENST00000354448_TCGA-TM-A84B_REV3L_chr6_111803952_-_PDE10A_chr6_165832265_length(amino acids)=543AA_start in transcript=345_stop in transcript=1976 MQTTTWPARCRGWIPANPPSPRPLSRRCRWCESSERPRQIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSI EKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCAN MYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVK KNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLE GHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEF WAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAA -------------------------------------------------------------- >In-frame_ENST00000368802_ENST00000539869_TCGA-TM-A84B_REV3L_chr6_111803952_-_PDE10A_chr6_165832265_length(transcript)=3952nt_BP=462nt CATCATCATGGCAACAAGAGCTGCAGCCTGGGACCGAGGAGCCCGTGTGATTCCCGGCGGTGGCGGCAGTGGCGGCAGCACCAGCACCGA CGAAAGCTCGAGGGCTTCTCTCCTGCGGCCCCTTGCCGGGTGCTCCTGAGGAGGCGGCGGCAGCAGCGCCTACACCGCCCCGCCCGCCGC TCCTCGAGGTGCCTCTGTGTGAGGGGAGGGGGCCGTGCCGAGAAGGGGAGGGGGCGCCGCCGCCGCTGCGGAGGGAGCCGCCGCCGCTGC TGCTGCCGCTGCCGGGTCGCCAGTGAAGGGAGGCAGTGGCGGCGGCGGCGAACATGTTTTCAGTAAGGATAGTGACTGCAGACTACTACA TGGCCAGCCCGCTGCAGGGGCTGGATACCTGCCAATCCCCCCTCACCCAGGCCCCTGTCAAGAAGGTGCCGGTGGTGCGAGTCTTCGGAG CGACCCCGGCAGATATATGCAAAAAACCTGGTGAATGCCGATCGTTGTGCGCTTTTCCAGGTGGACCATAAGAACAAGGAGTTATATTCA GACCTTTTTGATATTGGAGAGGAAAAGGAAGGAAAACCTGTCTTCAAGAAGACCAAAGAGATAAGATTTTCAATTGAGAAAGGAATTGCT GGCCAAGTAGCAAGAACAGGGGAAGTCCTGAACATTCCAGATGCCTATGCAGACCCACGCTTTAACAGAGAAGTAGACTTGTACACAGGC TACACCACGCGGAACATCCTGTGCATGCCCATCGTCAGCCGAGGCAGCGTGATAGGTGTGGTGCAGATGGTCAACAAAATCAGTGGCAGT GCCTTCTCTAAAACAGATGAAAACAACTTCAAAATGTTTGCCGTCTTTTGTGCTTTAGCCTTACACTGTGCTAATATGTATCATAGAATT CGCCACTCAGAGTGCATTTACCGGGTAACGATGGAAAAGCTGTCCTACCATAGCATTTGTACTTCAGAAGAGTGGCAAGGTCTCATGCAA TTCACCCTTCCCGTGCGTCTCTGCAAAGAAATTGAATTATTCCACTTTGACATTGGTCCTTTTGAAAACATGTGGCCTGGAATTTTTGTC TACATGGTTCATCGGTCCTGTGGGACATCCTGCTTTGAGCTTGAAAAGTTGTGTCGTTTTATTATGTCTGTGAAGAAGAACTATCGGCGG GTTCCTTATCACAACTGGAAGCATGCGGTCACTGTAGCACACTGCATGTATGCCATACTTCAGAACAATCACACGCTTTTCACAGACCTT GAGCGCAAAGGACTGCTGATTGCGTGTCTGTGTCATGACCTGGACCACAGGGGCTTCAGTAACAGCTACCTGCAGAAGTTCGACCACCCT CTGGCCGCTCTCTACTCCACTTCCACCATGGAGCAGCACCACTTCTCCCAGACTGTGTCCATCCTCCAGTTGGAAGGGCACAATATCTTC TCCACTCTGAGCTCCAGTGAATATGAGCAGGTGCTTGAGATCATCCGCAAAGCCATCATTGCCACAGACCTTGCTTTATACTTTGGAAAC AGGAAGCAGTTGGAAGAGATGTACCAGACCGGATCACTAAACCTTAATAATCAATCACATAGAGACCGTGTAATTGGTTTGATGATGACT GCCTGTGACCTTTGTTCTGTGACAAAACTGTGGCCCGTTACAAAATTGACGGCAAATGATATATATGCAGAATTCTGGGCTGAGGGTGAT GAAATGAAGAAATTGGGAATACAGCCTATTCCTATGATGGACAGAGACAAGAAGGATGAAGTCCCCCAAGGCCAGCTTGGGTTCTACAAT GCCGTGGCCATTCCCTGCTATACAACCCTTACCCAGATCCTCCCTCCCACGGAGCCTCTTCTGAAAGCATGCAGGGATAATCTCAGTCAG TGGGAGAAGGTGATTCGAGGGGAGGAGACTGCAACCTGGATTTCATCCCCATCCGTGGCTCAGAAGGCAGCTGCATCTGAAGATTGAGCA CTGGTCACCCTGACACGCTGTCCCACCTACAGATCCTCATCTTGCTTCTTTGACATTCTTTTCCTTTTTTTGGGGGGGGTGGGGGGAACC TGCACCTGGTAACTGGGGTGCAAACCTCTTCAAGAAGGTAACATCAAATAAATAAGTCAAGCAGAGGACTTCCTGCCAATCTCTTCTGTG AGGCATCATAGACACTGAGCAACCAGGACCACCCCCACGTTCAGAAATCAGCTGGCCAAGTGACTCCATTTGACTTGCAAACCAGCCTTT TCTAATAGGCTAATATTGCTGAGGCCTTAAAGGAAATGGACAAAAATTATCCAGAAGGGGTACTTTTCCATTGTATCTTTCTAATAAGGG TTTAAAATGGTACTATTATGGTATTGTACTTGGGCTTTAACATCAATGTTGCTTTGATGTTGTTGGATATAAATAGGAATTTTTACACAT TACTATTGTGAATGGTGAATGTTCATGTATGACCTACTTGTAATTAACTTGAGTTGTAGTCCACAGCCTCAGGACAAATGTCGTTGAGGT TACAGAGTAAGAAATGATGGCAAAACGTCAAACTCTTATTTCAGAGCTTCATGAATTTAGTTAGACTAAACATAATTCTTTAAGTTCAAC CTAAAGGGCTGAGATCAATAAATTTAACACTAGACGAAGTAGACTTCCTGTCTTTTTGAGAAGAGATGAGGTATATGTTACAATAAATCT CAGAACTTCAAGTAGCAGTTCAAAAGATGTCAGTTTTTAAAATTGTTTTTGTTGTTGTCTTGGCAGTTTTACTGAACCCTTTGCATAAAG AACAAAATAAAAGCTCGGCATTGTAATTTTTTTAATGGACAAGTCTTATGGATACGAAGGGTACATTTTTCATAATGATTCCTTTATATT TTCACTTTGTGTCATTGCAGAATTTTAGACTCTCATTCACAATGAAAAGTTTATTTTAAACATTGTTTAATTAAAATACCATACAGTTCT CTTTTAAACATCAAACCATAAAAAGTGTATTTTGTAATTTTACTCTGACCTGCCGCAGTCACCTCTCACTTATCTCTTCCACGTACTGCA CGGTCGTATTTCATGAGCTTTCTGTCCATAGCACAGAAACAGAGCAGAAAGTAGTACAATCATGTTGGACCTTCTTTCTGTTCTCTTTAC TCTTCTCACAGATCAGATCACTCCATAGAAGCCTGTGGGTTTCGATGGTTTCTTCTATACACCTTTTTGGTTGACCAGTATTACTATACA ATGTAAGTGTTTTAAAAAATACGAAAGTAATACTCTGCACCCCTTCCTACAAAGATGATAAAGCAGTCACTTCTGGCGCATTTTAATAAT TTAAAGATTTTTAGTGCAATGGCACGGTAACCTCCAAACCTGAATTAGACAGAGACTCACTCAGGAAGTGACAGGCCCATCATATCAAAT AACTTATTCACTTTTCATGTGGCAGGAAACTGGAATATCGCTTTTAATAAAATGGAAAAATATGCTTCTACATATTTACCACCATAGGCG TTTTGTTCATATGAGCCTGGTTTGTGCAAAATTAAATCAGAGGCTTCTACAACATGGTTTATTTATGTTGTAGCAAAGTTGGCTCTACAT AAACATTGTTCTTATTTTAAAATTAACACTATGTGTTCAGTTTTCTTGTGGGCTTCTGAAAGTTGCCATCTTCCCTCCGTGGAGCTCCAT TTGCTATTTTCATTATACACTATGAGGTAAAATGTAATAACAAAAGAGAGAGAAGTACCACTGTGGCTAGATATATACACACACATATAT ATATGGATGGATGTAATATATGTAGAACACACACATAGATGTATATAGGATACACACTCATGTATGTAAACGTATACATATGTGTATATA >In-frame_ENST00000368802_ENST00000539869_TCGA-TM-A84B_REV3L_chr6_111803952_-_PDE10A_chr6_165832265_length(amino acids)=543AA_start in transcript=345_stop in transcript=1976 MQTTTWPARCRGWIPANPPSPRPLSRRCRWCESSERPRQIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSI EKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCAN MYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVK KNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLE GHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEF WAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAA -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for REV3L-PDE10A |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for REV3L-PDE10A |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for REV3L-PDE10A |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | REV3L | C0221060 | Mobius Syndrome | 1 | ORPHANET |
Hgene | REV3L | C0853240 | Mobius II syndrome | 1 | ORPHANET |
Tgene | PDE10A | C4310791 | STRIATAL DEGENERATION, AUTOSOMAL DOMINANT 2 | 2 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Tgene | PDE10A | C4310792 | DYSKINESIA, LIMB AND OROFACIAL, INFANTILE-ONSET | 2 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Tgene | PDE10A | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Tgene | PDE10A | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | PDE10A | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Tgene | PDE10A | C0349204 | Nonorganic psychosis | 1 | PSYGENET |