Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:RGS5-RGS5 (FusionGDB2 ID:73372)

Fusion Gene Summary for RGS5-RGS5

Fusion gene summary

Fusion gene information	Fusion gene name: RGS5-RGS5
	Fusion gene ID: 73372
		Hgene	Tgene
	Gene symbol	RGS5	RGS5
	Gene ID	8490	8490
	Gene name	regulator of G protein signaling 5	regulator of G protein signaling 5
	Synonyms	MST092\|MST106\|MST129\|MSTP032\|MSTP092\|MSTP106\|MSTP129	MST092\|MST106\|MST129\|MSTP032\|MSTP092\|MSTP106\|MSTP129
	Cytomap	1q23.3	1q23.3
	Type of gene	protein-coding	protein-coding
	Description	regulator of G-protein signaling 5	regulator of G-protein signaling 5
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000367903, ENST00000534288, ENST00000313961, ENST00000530507, ENST00000527988,	ENST00000367903, ENST00000534288, ENST00000313961, ENST00000530507, ENST00000527988,
Fusion gene scores	* DoF score	5 X 7 X 2=70	6 X 8 X 3=144
	# samples	7	8
	** MAII score	log2(7/70*10)=0	log2(8/144*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RGS5 [Title/Abstract] AND RGS5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RGS5(163115693)-RGS5(163117290), # samples:1 RGS5(163112400)-RGS5(163112435), # samples:1 RGS5(163112435)-RGS5(163112400), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across RGS5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RGS5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AW961850	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
ChiTaRS5.0	N/A	BI491625	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
ChiTaRS5.0	N/A	BI491626	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-

Top

Fusion Gene ORF analysis for RGS5-RGS5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000367903	ENST00000367903	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
intron-intron	ENST00000367903	ENST00000534288	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
intron-intron	ENST00000367903	ENST00000313961	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
intron-intron	ENST00000367903	ENST00000530507	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
intron-intron	ENST00000367903	ENST00000527988	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
intron-3CDS	ENST00000534288	ENST00000367903	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
intron-intron	ENST00000534288	ENST00000534288	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
intron-intron	ENST00000534288	ENST00000313961	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
intron-intron	ENST00000534288	ENST00000530507	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
intron-intron	ENST00000534288	ENST00000527988	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
intron-3CDS	ENST00000313961	ENST00000367903	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
intron-intron	ENST00000313961	ENST00000534288	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
intron-intron	ENST00000313961	ENST00000313961	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
intron-intron	ENST00000313961	ENST00000530507	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
intron-intron	ENST00000313961	ENST00000527988	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
intron-3CDS	ENST00000530507	ENST00000367903	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
intron-intron	ENST00000530507	ENST00000534288	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
intron-intron	ENST00000530507	ENST00000313961	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
intron-intron	ENST00000530507	ENST00000530507	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
intron-intron	ENST00000530507	ENST00000527988	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
intron-3CDS	ENST00000527988	ENST00000367903	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
intron-intron	ENST00000527988	ENST00000534288	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
intron-intron	ENST00000527988	ENST00000313961	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
intron-intron	ENST00000527988	ENST00000530507	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
intron-intron	ENST00000527988	ENST00000527988	RGS5	chr1	163115693	-	RGS5	chr1	163117290	-
intron-intron	ENST00000367903	ENST00000367903	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
intron-intron	ENST00000367903	ENST00000534288	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
intron-3UTR	ENST00000367903	ENST00000313961	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
intron-intron	ENST00000367903	ENST00000530507	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
intron-intron	ENST00000367903	ENST00000527988	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
intron-intron	ENST00000534288	ENST00000367903	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
intron-intron	ENST00000534288	ENST00000534288	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
intron-3UTR	ENST00000534288	ENST00000313961	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
intron-intron	ENST00000534288	ENST00000530507	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
intron-intron	ENST00000534288	ENST00000527988	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
intron-intron	ENST00000313961	ENST00000367903	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
intron-intron	ENST00000313961	ENST00000534288	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
intron-3UTR	ENST00000313961	ENST00000313961	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
intron-intron	ENST00000313961	ENST00000530507	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
intron-intron	ENST00000313961	ENST00000527988	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
intron-intron	ENST00000530507	ENST00000367903	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
intron-intron	ENST00000530507	ENST00000534288	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
intron-3UTR	ENST00000530507	ENST00000313961	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
intron-intron	ENST00000530507	ENST00000530507	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
intron-intron	ENST00000530507	ENST00000527988	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
intron-intron	ENST00000527988	ENST00000367903	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
intron-intron	ENST00000527988	ENST00000534288	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
intron-3UTR	ENST00000527988	ENST00000313961	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
intron-intron	ENST00000527988	ENST00000530507	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
intron-intron	ENST00000527988	ENST00000527988	RGS5	chr1	163112400	+	RGS5	chr1	163112435	-
intron-intron	ENST00000367903	ENST00000367903	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-
intron-intron	ENST00000367903	ENST00000534288	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-
intron-3UTR	ENST00000367903	ENST00000313961	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-
intron-intron	ENST00000367903	ENST00000530507	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-
intron-intron	ENST00000367903	ENST00000527988	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-
intron-intron	ENST00000534288	ENST00000367903	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-
intron-intron	ENST00000534288	ENST00000534288	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-
intron-3UTR	ENST00000534288	ENST00000313961	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-
intron-intron	ENST00000534288	ENST00000530507	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-
intron-intron	ENST00000534288	ENST00000527988	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-
intron-intron	ENST00000313961	ENST00000367903	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-
intron-intron	ENST00000313961	ENST00000534288	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-
intron-3UTR	ENST00000313961	ENST00000313961	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-
intron-intron	ENST00000313961	ENST00000530507	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-
intron-intron	ENST00000313961	ENST00000527988	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-
intron-intron	ENST00000530507	ENST00000367903	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-
intron-intron	ENST00000530507	ENST00000534288	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-
intron-3UTR	ENST00000530507	ENST00000313961	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-
intron-intron	ENST00000530507	ENST00000530507	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-
intron-intron	ENST00000530507	ENST00000527988	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-
intron-intron	ENST00000527988	ENST00000367903	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-
intron-intron	ENST00000527988	ENST00000534288	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-
intron-3UTR	ENST00000527988	ENST00000313961	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-
intron-intron	ENST00000527988	ENST00000530507	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-
intron-intron	ENST00000527988	ENST00000527988	RGS5	chr1	163112435	+	RGS5	chr1	163112400	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for RGS5-RGS5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for RGS5-RGS5

Go to
FGviewer for the breakpoints of :-:
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for RGS5-RGS5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for RGS5-RGS5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for RGS5-RGS5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for RGS5-RGS5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	RGS5	C0020538	Hypertensive disease	1	CTD_human
Hgene	RGS5	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Hgene	RGS5	C0036341	Schizophrenia	1	PSYGENET
Tgene	RGS5	C0020538	Hypertensive disease	1	CTD_human
Tgene	RGS5	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Tgene	RGS5	C0036341	Schizophrenia	1	PSYGENET